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Volumn 96, Issue 2, 2012, Pages 255-264

β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway

Author keywords

Adrenergic receptor; Cardiac hypertrophy; Erk1 2; G protein; G protein subunits; Phosphorylation

Indexed keywords

BETA ADRENERGIC RECEPTOR; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

EID: 84867711595     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs249     Document Type: Article
Times cited : (66)

References (48)
  • 1
    • 0023905695 scopus 로고
    • Neurohormonal interactions and adaptations in congestive heart failure
    • Packer M. Neurohormonal interactions and adaptations in congestive heart failure. Circulation 1988;77:721-730.
    • (1988) Circulation , vol.77 , pp. 721-730
    • Packer, M.1
  • 2
    • 0242637601 scopus 로고    scopus 로고
    • What is the role of b-adrenergic signaling in heart failure?
    • Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of b-adrenergic signaling in heart failure? Circ Res 2003;93:896-906.
    • (2003) Circ Res , vol.93 , pp. 896-906
    • Lohse, M.J.1    Engelhardt, S.2    Eschenhagen, T.3
  • 3
    • 0035051054 scopus 로고    scopus 로고
    • Cytoplasmic signaling pathways that regulate cardiac hypertrophy
    • Molkentin JD, Dowern GW 2nd. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol 2001;63:391-426.
    • (2001) Annu Rev Physiol , vol.63 , pp. 391-426
    • Molkentin, J.D.1    Dowern, I.I.G.W.2
  • 4
    • 0034976707 scopus 로고    scopus 로고
    • Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure
    • Port JD, Bristow MR. Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. J Mol Cell Cardiol 2001;33:887-905.
    • (2001) J Mol Cell Cardiol , vol.33 , pp. 887-905
    • Port, J.D.1    Bristow, M.R.2
  • 5
    • 24044495268 scopus 로고    scopus 로고
    • Mechanisms of disease: B-adrenergic receptors-alterations in signal transduction and pharmacogenomics in heart failure
    • Feldman DS, Carnes CA, Abraham WT, Bristow MR. Mechanisms of disease: b-adrenergic receptors-alterations in signal transduction and pharmacogenomics in heart failure. Nat Clin Pract Cardiovasc Med 2005;2:475-483.
    • (2005) Nat Clin Pract Cardiovasc Med , vol.2 , pp. 475-483
    • Feldman, D.S.1    Carnes, C.A.2    Abraham, W.T.3    Bristow, M.R.4
  • 6
    • 0033535942 scopus 로고    scopus 로고
    • Progressive hypertrophy and heart failure in b1-adrenergic receptor transgenic mice
    • Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in b1-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA 1999;96: 7059-7064.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7059-7064
    • Engelhardt, S.1    Hein, L.2    Wiesmann, F.3    Lohse, M.J.4
  • 7
    • 0029912925 scopus 로고    scopus 로고
    • Adverse effects of chronic endogenous sympathetic drive induced by cardiac GSa overexpression
    • Iwase M, Bishop SP, Uechi M, Vatner DE, Shannon RP, Kudej RK et al. Adverse effects of chronic endogenous sympathetic drive induced by cardiac GSa overexpression. Circ Res 1996;78:517-524.
    • (1996) Circ Res , vol.78 , pp. 517-524
    • Iwase, M.1    Bishop, S.P.2    Uechi, M.3    Vatner, D.E.4    Shannon, R.P.5    Kudej, R.K.6
  • 8
    • 0035941418 scopus 로고    scopus 로고
    • Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase A
    • Antos CL, Frey N, Marx SO, Reiken S, Gaburjakova M, Richardson JA et al. Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase A. Circ Res 2001;89:997-1004.
    • (2001) Circ Res , vol.89 , pp. 997-1004
    • Antos, C.L.1    Frey, N.2    Marx, S.O.3    Reiken, S.4    Gaburjakova, M.5    Richardson, J.A.6
  • 9
    • 0033554838 scopus 로고    scopus 로고
    • Altering the receptor-effector ratio by transgenic overexpression of type v adenylyl cyclase: Enhanced basal catalytic activity and function without increased cardiomyocyte b-adrenergic signalling
    • Tepe NM, Lorenz JN, Yatani A, Dash R, Kranias EG, Dorn GW 2nd et al. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte b-adrenergic signalling. Biochemistry 1999;38:16706-16713.
    • (1999) Biochemistry , vol.38 , pp. 16706-16713
    • Tepe, N.M.1    Lorenz, J.N.2    Yatani, A.3    Dash, R.4    Kranias, E.G.5    Dorn, I.I.G.W.6
  • 10
    • 0345120936 scopus 로고    scopus 로고
    • Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy
    • Roth DM, Gao MH, Lai NC, Drumm J, Dalton N, Zhou JY et al. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation 1999;99:3099-3102.
    • (1999) Circulation , vol.99 , pp. 3099-3102
    • Roth, D.M.1    Gao, M.H.2    Lai, N.C.3    Drumm, J.4    Dalton, N.5    Zhou, J.Y.6
  • 11
    • 78649857349 scopus 로고    scopus 로고
    • Role of chronic ryanodine receptor phosphorylation in heart failure and b-adrenergic receptor blockade in mice
    • Shan J, Betzenhauser MJ, Kushnir A, Reiken S, Meli AC, Wronska A et al. Role of chronic ryanodine receptor phosphorylation in heart failure and b-adrenergic receptor blockade in mice. J Clin Invest 2010;120:4375-4387.
    • (2010) J Clin Invest , vol.120 , pp. 4375-4387
    • Shan, J.1    Betzenhauser, M.J.2    Kushnir, A.3    Reiken, S.4    Meli, A.C.5    Wronska, A.6
  • 12
    • 58149351369 scopus 로고    scopus 로고
    • A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy
    • Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ. A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med 2009;15:75-83.
    • (2009) Nat Med , vol.15 , pp. 75-83
    • Lorenz, K.1    Schmitt, J.P.2    Schmitteckert, E.M.3    Lohse, M.J.4
  • 13
    • 0346874333 scopus 로고    scopus 로고
    • Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
    • Lorenz K, Lohse MJ, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature 2003;426:574-579.
    • (2003) Nature , vol.426 , pp. 574-579
    • Lorenz, K.1    Lohse, M.J.2    Quitterer, U.3
  • 14
  • 15
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995;9:726-735.
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 16
    • 0037040165 scopus 로고    scopus 로고
    • Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor
    • Thomas WG, Brandenburger Y, Autelitano DJ, Pham T, Qian H, Hannan RD. Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor. Circ Res 2002;90:135-142.
    • (2002) Circ Res , vol.90 , pp. 135-142
    • Thomas, W.G.1    Brandenburger, Y.2    Autelitano, D.J.3    Pham, T.4    Qian, H.5    Hannan, R.D.6
  • 18
    • 0031669940 scopus 로고    scopus 로고
    • Cellular mechanisms of cardiac hypertrophy
    • Sugden PH, Clerk A. Cellular mechanisms of cardiac hypertrophy. J Mol Med (Berl) 1998;76:725-746.
    • (1998) J Mol Med (Berl) , vol.76 , pp. 725-746
    • Sugden, P.H.1    Clerk, A.2
  • 19
    • 0033840752 scopus 로고    scopus 로고
    • Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy
    • Ueyama T, Kawashima S, Sakoda T, Rikitake Y, Ishida T, Kawai M et al. Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy. J Mol Cell Cardiol 2000;32:947-960.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 947-960
    • Ueyama, T.1    Kawashima, S.2    Sakoda, T.3    Rikitake, Y.4    Ishida, T.5    Kawai, M.6
  • 22
    • 0033675205 scopus 로고    scopus 로고
    • Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP-dependent extracellular signal-regulated kinase activation
    • Henaff M, Hatem SN, Mercadier JJ. Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP-dependent extracellular signal-regulated kinase activation. Mol Pharmacol 2000;58:1546-1553.
    • (2000) Mol Pharmacol , vol.58 , pp. 1546-1553
    • Henaff, M.1    Hatem, S.N.2    Mercadier, J.J.3
  • 23
    • 76449115479 scopus 로고    scopus 로고
    • The b1-adrenergic receptor mediates extracellular signal-regulated kinase activation via Gas
    • Zheng J, Shen H, Xiong Y, Yang X, He J. The b1-adrenergic receptor mediates extracellular signal-regulated kinase activation via Gas. Amino Acids 2010;38:75-84.
    • (2010) Amino Acids , vol.38 , pp. 75-84
    • Zheng, J.1    Shen, H.2    Xiong, Y.3    Yang, X.4    He, J.5
  • 24
    • 78649835004 scopus 로고    scopus 로고
    • Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice
    • Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lehnart SE et al. Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest 2010;120:4388-4398.
    • (2010) J Clin Invest , vol.120 , pp. 4388-4398
    • Shan, J.1    Kushnir, A.2    Betzenhauser, M.J.3    Reiken, S.4    Li, J.5    Lehnart, S.E.6
  • 25
    • 34848902937 scopus 로고    scopus 로고
    • Ca2+-and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure
    • Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H et al. Ca2+-and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest 2007;117:2431-2444.
    • (2007) J Clin Invest , vol.117 , pp. 2431-2444
    • Nakayama, H.1    Chen, X.2    Baines, C.P.3    Klevitsky, R.4    Zhang, X.5    Zhang, H.6
  • 26
    • 0242664032 scopus 로고    scopus 로고
    • Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol
    • Kedzierski RM, Grayburn PA, Kisanuki YY, Williams CS, Hammer RE, Richardson JA et al. Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol. Mol Cell Biol 2003;23:8226-8232.
    • (2003) Mol Cell Biol , vol.23 , pp. 8226-8232
    • Kedzierski, R.M.1    Grayburn, P.A.2    Kisanuki, Y.Y.3    Williams, C.S.4    Hammer, R.E.5    Richardson, J.A.6
  • 27
    • 58149305990 scopus 로고    scopus 로고
    • With great power comes great responsibility: Using mouse genetics to study cardiac hypertrophy and failure
    • Molkentin JD, Robbins J. With great power comes great responsibility: Using mouse genetics to study cardiac hypertrophy and failure. J Mol Cell Cardiol 2009;46:130-136.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 130-136
    • Molkentin, J.D.1    Robbins, J.2
  • 28
    • 77950909970 scopus 로고    scopus 로고
    • Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart
    • Kimura TE, Jin J, Zi M, Prehar S, Liu W, Oceandy D et al. Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ Res 2010;106: 961-970.
    • (2010) Circ Res , vol.106 , pp. 961-970
    • Kimura, T.E.1    Jin, J.2    Zi, M.3    Prehar, S.4    Liu, W.5    Oceandy, D.6
  • 29
    • 79961091829 scopus 로고    scopus 로고
    • Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo
    • van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci USA 2011;108:12331-12336.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12331-12336
    • Van Berlo, J.H.1    Elrod, J.W.2    Aronow, B.J.3    Pu, W.T.4    Molkentin, J.D.5
  • 30
    • 0030051750 scopus 로고    scopus 로고
    • The role of protein kinases in adaptational growth of the heart
    • Bogoyevitch MA, Sugden PH. The role of protein kinases in adaptational growth of the heart. Int J Biochem Cell Biol 1996;28:1-12.
    • (1996) Int J Biochem Cell Biol , vol.28 , pp. 1-12
    • Bogoyevitch, M.A.1    Sugden, P.H.2
  • 31
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 2006;7:589-600.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 589-600
    • Heineke, J.1    Molkentin, J.D.2
  • 32
    • 77649162900 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy
    • Kehat I, Molkentin JD. Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy. Ann N Y Acad Sci 2010;1188:96-102.
    • (2010) Ann N y Acad Sci , vol.1188 , pp. 96-102
    • Kehat, I.1    Molkentin, J.D.2
  • 33
    • 0034383952 scopus 로고    scopus 로고
    • The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    • Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 2000;19:6341-6350.
    • (2000) EMBO J , vol.19 , pp. 6341-6350
    • Bueno, O.F.1    De Windt, L.J.2    Tymitz, K.M.3    Witt, S.A.4    Kimball, T.R.5    Klevitsky, R.6
  • 34
    • 79251617662 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth
    • Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M et al. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ Res 2011;108:176-183.
    • (2011) Circ Res , vol.108 , pp. 176-183
    • Kehat, I.1    Davis, J.2    Tiburcy, M.3    Accornero, F.4    Saba-El-Leil, M.K.5    Maillet, M.6
  • 38
    • 84856242093 scopus 로고    scopus 로고
    • ERK phosphorylation and nuclear accumulation: Insights from single-cell imaging
    • Caunt CJ, McArdle CA. ERK phosphorylation and nuclear accumulation: insights from single-cell imaging. Biochem Soc Trans 2012;40:224-229.
    • (2012) Biochem Soc Trans , vol.40 , pp. 224-229
    • Caunt, C.J.1    McArdle, C.A.2
  • 39
    • 52049108218 scopus 로고    scopus 로고
    • Identification and characterization of a general nuclear translocation signal in signaling proteins
    • Chuderland D, Konson A, Seger R. Identification and characterization of a general nuclear translocation signal in signaling proteins. Mol Cell 2008;31:850-861.
    • (2008) Mol Cell , vol.31 , pp. 850-861
    • Chuderland, D.1    Konson, A.2    Seger, R.3
  • 42
    • 0033515617 scopus 로고    scopus 로고
    • Identification and expression of d-isoforms of the multifunctional Ca2 +calmodulin-dependent protein kinase in failing and nonfailing human myocardium
    • Hoch B, Meyer R, Hetzer R, Krause EG, Karczewski P. Identification and expression of d-isoforms of the multifunctional Ca2 +calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ Res 1999;84:713-721.
    • (1999) Circ Res , vol.84 , pp. 713-721
    • Hoch, B.1    Meyer, R.2    Hetzer, R.3    Krause, E.G.4    Karczewski, P.5
  • 43
    • 0032897465 scopus 로고    scopus 로고
    • Activity of cAMP-dependent protein kinase and Ca2 +calmodulin-dependent protein kinase in failing and nonfailing human hearts
    • Kirchhefer U, Schmitz W, Scholz H, Neumann J. Activity of cAMP-dependent protein kinase and Ca2 +calmodulin-dependent protein kinase in failing and nonfailing human hearts. Cardiovasc Res 1999;42:254-261.
    • (1999) Cardiovasc Res , vol.42 , pp. 254-261
    • Kirchhefer, U.1    Schmitz, W.2    Scholz, H.3    Neumann, J.4
  • 44
    • 74149088545 scopus 로고    scopus 로고
    • B-Adrenergic receptor signaling in the heart: Role of CaMKII
    • Grimm M, Brown JH. b-Adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol 2010;48:322-330.
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 322-330
    • Grimm, M.1    Brown, J.H.2
  • 45
    • 36849036738 scopus 로고    scopus 로고
    • CaMKIId isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses
    • Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N et al. CaMKIId isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem 2007;282:35078-35087.
    • (2007) J Biol Chem , vol.282 , pp. 35078-35087
    • Zhang, T.1    Kohlhaas, M.2    Backs, J.3    Mishra, S.4    Phillips, W.5    Dybkova, N.6
  • 46
    • 27644566636 scopus 로고    scopus 로고
    • Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition
    • Münzel F, Mühlhäuser U, Zimmermann WH, Didié M, Schneiderbanger K, Schubert P et al. Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition. Cardiovasc Res 2005;68:464-474.
    • (2005) Cardiovasc Res , vol.68 , pp. 464-474
    • Münzel, F.1    Mühlhäuser, U.2    Zimmermann, W.H.3    Didié, M.4    Schneiderbanger, K.5    Schubert, P.6
  • 47
    • 0034737730 scopus 로고    scopus 로고
    • Inhibition of extracellular signal-regulated kinase enhances ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart
    • Yue TL, Wang C, Gu JL, Ma XL, Kumar S, Lee JC et al. Inhibition of extracellular signal-regulated kinase enhances ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circ Res 2000;86:692-699.
    • (2000) Circ Res , vol.86 , pp. 692-699
    • Yue, T.L.1    Wang, C.2    Gu, J.L.3    Ma, X.L.4    Kumar, S.5    Lee, J.C.6


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