Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 19, Issue 6, 2014, Pages 574-585

  Ambrose, Lucy J A ^a   Abd Jamil, Amira H ^a   Gomes, Renata S M ^a   Carter, Emma E ^a   Carr, Carolyn A ^a   Clarke, Kieran ^a   Heather, Lisa C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

cardiac pharmacology; high altitude medicine and physiology; molecular biology

Indexed keywords

ACONITATE HYDRATASE; CASPASE 3; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; CYTOPROTECTIVE AGENT; DIMETHYLOXALYLGLYCINE; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LACTATE DEHYDROGENASE; LACTIC ACID; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; VASCULOTROPIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DICARBOXYLIC AMINO ACID; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, MOUSE; MESSENGER RNA; OXALYLGLYCINE; SLC2A1 PROTEIN, MOUSE;

AEROBIC METABOLISM; ANAEROBIC GLYCOLYSIS; ANIMAL CELL; ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID OXIDATION; GLUCOSE UTILIZATION; HEART MITOCHONDRION; HEART MUSCLE CELL; HYPOXIC CELL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; AGONISTS; ANIMAL; CELL LINE; CELL RESPIRATION; DRUG EFFECTS; GENETICS; GLYCOLYSIS; HEART CONTRACTION; METABOLISM; SIGNAL TRANSDUCTION; TIME; UPREGULATION;

ACONITATE HYDRATASE; AMINO ACIDS, DICARBOXYLIC; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELL LINE; CELL RESPIRATION; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX IV; GLUCOSE TRANSPORTER TYPE 1; GLYCOLYSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTIC ACID; MICE; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; OXYGEN CONSUMPTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 84907538533     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248414524480     Document Type: Article

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