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Volumn 17, Issue 2, 2017, Pages 93-115

Cell cycle proteins as promising targets in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA KINASE; AURORA KINASE INHIBITOR; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; POLO LIKE KINASE; POLO LIKE KINASE INHIBITOR; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; WEE1 PROTEIN; AURORA A KINASE; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 2; NUCLEAR PROTEIN; ONCOPROTEIN; POLO-LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; WEE1 PROTEIN, HUMAN;

EID: 85010843462     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc.2016.138     Document Type: Review
Times cited : (1481)

References (250)
  • 1
    • 81255205373 scopus 로고    scopus 로고
    • A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
    • Anders, L. et al. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 20, 620-634 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 620-634
    • Anders, L.1
  • 2
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: A changing paradigm
    • Malumbres, M. & Barbacid, M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 9, 153-166 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 3
    • 84881528286 scopus 로고    scopus 로고
    • A new kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis
    • Kollmann, K. et al. A new kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24, 167-181 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 167-181
    • Kollmann, K.1
  • 4
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1, 222-231 (2001).
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 5
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr, C. J. & Roberts, J. M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18, 2699-2711 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 6
    • 84962071033 scopus 로고    scopus 로고
    • Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases
    • Hydbring, P., Malumbres, M. & Sicinski, P. Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat. Rev. Mol. Cell Biol. 17, 280-292 (2016).
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , pp. 280-292
    • Hydbring, P.1    Malumbres, M.2    Sicinski, P.3
  • 7
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim, R. et al. The landscape of somatic copy-number alteration across human cancers. Nature 463, 899-905 (2010).
    • (2010) Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1
  • 8
    • 0028652269 scopus 로고
    • CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
    • Schmidt, E. E., Ichimura, K., Reifenberger, G. & Collins, V. P. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res. 54, 6321-6324 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 6321-6324
    • Schmidt, E.E.1    Ichimura, K.2    Reifenberger, G.3    Collins, V.P.4
  • 9
    • 0028978274 scopus 로고
    • A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
    • Wölfel, T. et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269, 1281-1284 (1995).
    • (1995) Science , vol.269 , pp. 1281-1284
    • Wölfel, T.1
  • 10
    • 0033523992 scopus 로고    scopus 로고
    • Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations
    • Corcoran, M. M. et al. Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. Oncogene 18, 6271-6277 (1999).
    • (1999) Oncogene , vol.18 , pp. 6271-6277
    • Corcoran, M.M.1
  • 11
    • 0035803395 scopus 로고    scopus 로고
    • Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors
    • Sotillo, R. et al. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J. 20, 6637-6647 (2001).
    • (2001) EMBO J. , vol.20 , pp. 6637-6647
    • Sotillo, R.1
  • 12
    • 0035818589 scopus 로고    scopus 로고
    • Invasive melanoma in Cdk4-targeted mice
    • Sotillo, R. et al. Invasive melanoma in Cdk4-targeted mice. Proc. Natl Acad. Sci. USA 98, 13312-13317 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 13312-13317
    • Sotillo, R.1
  • 13
    • 0028243879 scopus 로고
    • Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    • Wang, T. C. et al. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 369, 669-671 (1994).
    • (1994) Nature , vol.369 , pp. 669-671
    • Wang, T.C.1
  • 14
    • 33947221512 scopus 로고    scopus 로고
    • Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis
    • Rojas, P. et al. Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis. Oncogene 26, 1723-1730 (2007).
    • (2007) Oncogene , vol.26 , pp. 1723-1730
    • Rojas, P.1
  • 15
    • 79251475581 scopus 로고    scopus 로고
    • Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis
    • Wang, X., Sistrunk, C. & Rodriguez-Puebla, M. L. Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis. Am. J. Pathol. 178, 345-354 (2011).
    • (2011) Am. J. Pathol. , vol.178 , pp. 345-354
    • Wang, X.1    Sistrunk, C.2    Rodriguez-Puebla, M.L.3
  • 16
    • 0037086276 scopus 로고    scopus 로고
    • Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: Cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation
    • Yamamoto, H. et al. Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation. Cancer Res. 62, 1641-1647 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 1641-1647
    • Yamamoto, H.1
  • 18
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu, Q., Geng, Y. & Sicinski, P. Specific protection against breast cancers by cyclin D1 ablation. Nature 411, 1017-1021 (2001).
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 19
    • 0037050256 scopus 로고    scopus 로고
    • Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin e
    • Bowe, D. B., Kenney, N. J., Adereth, Y. & Maroulakou, I. G. Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E. Oncogene 21, 291-298 (2002).
    • (2002) Oncogene , vol.21 , pp. 291-298
    • Bowe, D.B.1    Kenney, N.J.2    Adereth, Y.3    Maroulakou, I.G.4
  • 20
    • 30344470210 scopus 로고    scopus 로고
    • Requirement for CDK4 kinase function in breast cancer
    • Yu, Q. et al. Requirement for CDK4 kinase function in breast cancer. Cancer Cell 9, 23-32 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 23-32
    • Yu, Q.1
  • 21
    • 28544433465 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis
    • Reddy, H. K. et al. Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res. 65, 10174-10178 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 10174-10178
    • Reddy, H.K.1
  • 22
    • 30344479175 scopus 로고    scopus 로고
    • Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
    • Landis, M. W., Pawlyk, B. S., Li, T., Sicinski, P. & Hinds, P. W. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9, 13-22 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 13-22
    • Landis, M.W.1    Pawlyk, B.S.2    Li, T.3    Sicinski, P.4    Hinds, P.W.5
  • 23
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451-461 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1
  • 24
    • 59149089409 scopus 로고    scopus 로고
    • A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis
    • Hu, M. G. et al. A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res. 69, 810-818 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 810-818
    • Hu, M.G.1
  • 25
    • 77954279920 scopus 로고    scopus 로고
    • A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
    • Puyol, M. et al. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 18, 63-73 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 63-73
    • Puyol, M.1
  • 26
    • 84867618851 scopus 로고    scopus 로고
    • The requirement for cyclin D function in tumor maintenance
    • Choi, Y. J. et al. The requirement for cyclin D function in tumor maintenance. Cancer Cell 22, 438-451 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 438-451
    • Choi, Y.J.1
  • 27
    • 84867602759 scopus 로고    scopus 로고
    • Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia
    • Sawai, C. M. et al. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell 22, 452-465 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 452-465
    • Sawai, C.M.1
  • 28
    • 0029048491 scopus 로고
    • Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle
    • Watanabe, N., Broome, M. & Hunter, T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 14, 1878-1891 (1995).
    • (1995) EMBO J. , vol.14 , pp. 1878-1891
    • Watanabe, N.1    Broome, M.2    Hunter, T.3
  • 29
    • 0034665635 scopus 로고    scopus 로고
    • Cell cycle-regulated phosphorylation of p220NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription
    • Ma, T. et al. Cell cycle-regulated phosphorylation of p220NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14, 2298-2313 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2298-2313
    • Ma, T.1
  • 30
    • 0034730321 scopus 로고    scopus 로고
    • Nucleophosmin/B23 is a target of CDK2/cyclin e in centrosome duplication
    • Okuda, M. et al. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103, 127-140 (2000).
    • (2000) Cell , vol.103 , pp. 127-140
    • Okuda, M.1
  • 31
    • 0035921849 scopus 로고    scopus 로고
    • Human F-box protein hCdc4 targets cyclin e for proteolysis and is mutated in a breast cancer cell line
    • Strohmaier, H. et al. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413, 316-322 (2001).
    • (2001) Nature , vol.413 , pp. 316-322
    • Strohmaier, H.1
  • 32
    • 0035812709 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitination of cyclin e by the SCFFbw7 ubiquitin ligase
    • Koepp, D. M. et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294, 173-177 (2001).
    • (2001) Science , vol.294 , pp. 173-177
    • Koepp, D.M.1
  • 33
    • 79952741351 scopus 로고    scopus 로고
    • Cyclin e amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients
    • Scaltriti, M. et al. Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients. Proc. Natl Acad. Sci. USA 108, 3761-3766 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 3761-3766
    • Scaltriti, M.1
  • 34
    • 84888349734 scopus 로고    scopus 로고
    • Synthetic lethality between CCNE1 amplification and loss of BRCA1
    • Etemadmoghadam, D. et al. Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proc. Natl Acad. Sci. USA 110, 19489-19494 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 19489-19494
    • Etemadmoghadam, D.1
  • 35
    • 0037102310 scopus 로고    scopus 로고
    • HCDC4 gene mutations in endometrial cancer
    • Spruck, C. H. et al. hCDC4 gene mutations in endometrial cancer. Cancer Res. 62, 4535-4539 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4535-4539
    • Spruck, C.H.1
  • 36
    • 29244460649 scopus 로고    scopus 로고
    • CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability
    • Kemp, Z. et al. CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. Cancer Res. 65, 11361-11366 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 11361-11366
    • Kemp, Z.1
  • 37
    • 79955490608 scopus 로고    scopus 로고
    • Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin e
    • Akli, S., Van Pelt, C. S., Bui, T., Meijer, L. & Keyomarsi, K. Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E. Cancer Res. 71, 3377-3386 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3377-3386
    • Akli, S.1    Van Pelt, C.S.2    Bui, T.3    Meijer, L.4    Keyomarsi, K.5
  • 38
    • 0032030883 scopus 로고    scopus 로고
    • Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma
    • Chao, Y. et al. Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma. Cancer Res. 58, 985-990 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 985-990
    • Chao, Y.1
  • 39
    • 0033038931 scopus 로고    scopus 로고
    • Expression of cell cycle markers in colorectal carcinoma: Superiority of cyclin A as an indicator of poor prognosis
    • Handa, K., Yamakawa, M., Takeda, H., Kimura, S. & Takahashi, T. Expression of cell cycle markers in colorectal carcinoma: superiority of cyclin A as an indicator of poor prognosis. Int. J. Cancer 84, 225-233 (1999).
    • (1999) Int. J. Cancer , vol.84 , pp. 225-233
    • Handa, K.1    Yamakawa, M.2    Takeda, H.3    Kimura, S.4    Takahashi, T.5
  • 40
    • 0036473059 scopus 로고    scopus 로고
    • Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment
    • Michalides, R. et al. Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment. Br. J. Cancer 86, 402-408 (2002).
    • (2002) Br. J. Cancer , vol.86 , pp. 402-408
    • Michalides, R.1
  • 41
    • 0035942224 scopus 로고    scopus 로고
    • Skp2 is oncogenic and overexpressed in human cancers
    • Gstaiger, M. et al. Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl Acad. Sci. USA 98, 5043-5048 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5043-5048
    • Gstaiger, M.1
  • 42
    • 0029119560 scopus 로고
    • CDC25 phosphatases as potential human oncogenes
    • Galaktionov, K. et al. CDC25 phosphatases as potential human oncogenes. Science 269, 1575-1577 (1995).
    • (1995) Science , vol.269 , pp. 1575-1577
    • Galaktionov, K.1
  • 43
    • 0034212635 scopus 로고    scopus 로고
    • Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma
    • Takemasa, I. et al. Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma. Cancer Res. 60, 3043-3050 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3043-3050
    • Takemasa, I.1
  • 44
    • 0034491671 scopus 로고    scopus 로고
    • Cell cycle-related phosphatases CDC25A and B expression correlates with survival in ovarian cancer patients
    • Broggini, M. et al. Cell cycle-related phosphatases CDC25A and B expression correlates with survival in ovarian cancer patients. Anticancer Res. 20, 4835-4840 (2000).
    • (2000) Anticancer Res. , vol.20 , pp. 4835-4840
    • Broggini, M.1
  • 45
    • 0031028246 scopus 로고    scopus 로고
    • Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin e
    • Bortner, D. M. & Rosenberg, M. P. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. Mol. Cell. Biol. 17, 453-459 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 453-459
    • Bortner, D.M.1    Rosenberg, M.P.2
  • 46
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27Kip1 is haplo-insufficient for tumour suppression
    • Fero, M. L., Randel, E., Gurley, K. E., Roberts, J. M. & Kemp, C. J. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 396, 177-180 (1998).
    • (1998) Nature , vol.396 , pp. 177-180
    • Fero, M.L.1    Randel, E.2    Gurley, K.E.3    Roberts, J.M.4    Kemp, C.J.5
  • 48
    • 0033575959 scopus 로고    scopus 로고
    • Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice
    • Yao, Y. et al. Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice. Oncogene 18, 5159-5166 (1999).
    • (1999) Oncogene , vol.18 , pp. 5159-5166
    • Yao, Y.1
  • 49
    • 33847013064 scopus 로고    scopus 로고
    • Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability
    • Ray, D. et al. Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability. Cancer Res. 67, 984-991 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 984-991
    • Ray, D.1
  • 50
    • 34547107624 scopus 로고    scopus 로고
    • Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice
    • Ray, D. et al. Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Cancer Res. 67, 6605-6611 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 6605-6611
    • Ray, D.1
  • 51
    • 0041327168 scopus 로고    scopus 로고
    • Proliferation of cancer cells despite CDK2 inhibition
    • Tetsu, O. & McCormick, F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 3, 233-245 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 233-245
    • Tetsu, O.1    McCormick, F.2
  • 52
    • 66349114807 scopus 로고    scopus 로고
    • Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53
    • Padmakumar, V. C., Aleem, E., Berthet, C., Hilton, M. B. & Kaldis, P. Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53. Mol. Cell. Biol. 29, 2582-2593 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 2582-2593
    • Padmakumar, V.C.1    Aleem, E.2    Berthet, C.3    Hilton, M.B.4    Kaldis, P.5
  • 53
    • 35448958408 scopus 로고    scopus 로고
    • Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis
    • Macias, E., Kim, Y., Miliani de Marval, P. L., Klein-Szanto, A. & Rodriguez-Puebla, M. L. Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. Cancer Res. 67, 9713-9720 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 9713-9720
    • Macias, E.1    Kim, Y.2    Miliani De Marval, P.L.3    Klein-Szanto, A.4    Rodriguez-Puebla, M.L.5
  • 54
    • 84938489166 scopus 로고    scopus 로고
    • MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2
    • Gillam, M. P. et al. MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2. Oncogene 34, 932-938 (2015).
    • (2015) Oncogene , vol.34 , pp. 932-938
    • Gillam, M.P.1
  • 55
    • 77949730783 scopus 로고    scopus 로고
    • Cdk2 suppresses cellular senescence induced by the c-myc oncogene
    • Campaner, S. et al. Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat. Cell Biol. 12, 54-59 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 54-59
    • Campaner, S.1
  • 56
    • 76249101395 scopus 로고    scopus 로고
    • Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
    • Hydbring, P. et al. Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation. Proc. Natl Acad. Sci. USA 107, 58-63 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 58-63
    • Hydbring, P.1
  • 57
    • 10944228764 scopus 로고    scopus 로고
    • Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
    • Du, J. et al. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell 6, 565-576 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 565-576
    • Du, J.1
  • 58
    • 79955871521 scopus 로고    scopus 로고
    • Cdk2-null mice are resistant to ERBB-2-induced mammary tumorigenesis
    • Ray, D., Terao, Y., Christov, K., Kaldis, P. & Kiyokawa, H. Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis. Neoplasia 13, 439-444 (2011).
    • (2011) Neoplasia , vol.13 , pp. 439-444
    • Ray, D.1    Terao, Y.2    Christov, K.3    Kaldis, P.4    Kiyokawa, H.5
  • 59
    • 34547952048 scopus 로고    scopus 로고
    • Cdk1 is sufficient to drive the mammalian cell cycle
    • Santamaria, D. et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815 (2007).
    • (2007) Nature , vol.448 , pp. 811-815
    • Santamaria, D.1
  • 60
    • 77951184302 scopus 로고    scopus 로고
    • Progressive activation of cyclinB1-Cdk1 coordinates entry to mitosis
    • Gavet, O. & Pines, J. Progressive activation of cyclinB1-Cdk1 coordinates entry to mitosis. Dev. Cell 18, 533-543 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 533-543
    • Gavet, O.1    Pines, J.2
  • 61
    • 0028783413 scopus 로고
    • Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15
    • Mueller, P. R., Coleman, T. R., Kumagai, A. & Dunphy, W. G. Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 270, 86-90 (1995).
    • (1995) Science , vol.270 , pp. 86-90
    • Mueller, P.R.1    Coleman, T.R.2    Kumagai, A.3    Dunphy, W.G.4
  • 62
    • 0026616796 scopus 로고
    • Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
    • Parker, L. L. & Piwnica-Worms, H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257, 1955-1957 (1992).
    • (1992) Science , vol.257 , pp. 1955-1957
    • Parker, L.L.1    Piwnica-Worms, H.2
  • 63
    • 84957623685 scopus 로고    scopus 로고
    • Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
    • Beltran, H. et al. Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nat. Med. 22, 298-305 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 298-305
    • Beltran, H.1
  • 64
    • 84901766653 scopus 로고    scopus 로고
    • Cyclin B2 and p53 control proper timing of centrosome separation
    • Nam, H. J. & van Deursen, J. M. Cyclin B2 and p53 control proper timing of centrosome separation. Nat. Cell Biol. 16, 538-549 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , pp. 538-549
    • Nam, H.J.1    Van Deursen, J.M.2
  • 65
    • 84857956418 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
    • Diril, M. K. et al. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc. Natl Acad. Sci. USA 109, 3826-3831 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 3826-3831
    • Diril, M.K.1
  • 66
    • 84978676921 scopus 로고    scopus 로고
    • CDK1 is a synthetic lethal target for KRAS mutant tumours
    • Costa-Cabral, S. et al. CDK1 is a synthetic lethal target for KRAS mutant tumours. PLoS ONE 11, e0149099 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0149099
    • Costa-Cabral, S.1
  • 67
    • 34447137342 scopus 로고    scopus 로고
    • Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
    • Goga, A., Yang, D., Tward, A. D., Morgan, D. O. & Bishop, J. M. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat. Med. 13, 820-827 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 820-827
    • Goga, A.1    Yang, D.2    Tward, A.D.3    Morgan, D.O.4    Bishop, J.M.5
  • 68
    • 84861735363 scopus 로고    scopus 로고
    • MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
    • Horiuchi, D. et al. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J. Exp. Med. 209, 679-696 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 679-696
    • Horiuchi, D.1
  • 69
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao, H. & Piwnica-Worms, H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21, 4129-4139 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 70
    • 0034641724 scopus 로고    scopus 로고
    • Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
    • Matsuoka, S. et al. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl Acad. Sci. USA 97, 10389-10394 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10389-10394
    • Matsuoka, S.1
  • 71
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • El-Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1
  • 72
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
    • Sanchez, Y. et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501 (1997).
    • (1997) Science , vol.277 , pp. 1497-1501
    • Sanchez, Y.1
  • 73
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • Peng, C. Y. et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505 (1997).
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.Y.1
  • 74
    • 0031035528 scopus 로고    scopus 로고
    • Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
    • O'Connell, M. J., Raleigh, J. M., Verkade, H. M. & Nurse, P. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J. 16, 545-554 (1997).
    • (1997) EMBO J. , vol.16 , pp. 545-554
    • O'Connell, M.J.1    Raleigh, J.M.2    Verkade, H.M.3    Nurse, P.4
  • 75
    • 79952718383 scopus 로고    scopus 로고
    • Detection of CHK1 and CCND1 gene copy number changes in breast cancer with dual-colour fluorescence in-situ hybridization
    • Mu, K. et al. Detection of CHK1 and CCND1 gene copy number changes in breast cancer with dual-colour fluorescence in-situ hybridization. Histopathology 58, 601-607 (2011).
    • (2011) Histopathology , vol.58 , pp. 601-607
    • Mu, K.1
  • 76
    • 0035503171 scopus 로고    scopus 로고
    • Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability
    • Menoyo, A. et al. Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. Cancer Res. 61, 7727-7730 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 7727-7730
    • Menoyo, A.1
  • 77
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
    • Liu, Q. et al. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev. 14, 1448-1459 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1448-1459
    • Liu, Q.1
  • 78
    • 77954758936 scopus 로고    scopus 로고
    • Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53
    • Fishler, T. et al. Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53. Oncogene 29, 4007-4017 (2010).
    • (2010) Oncogene , vol.29 , pp. 4007-4017
    • Fishler, T.1
  • 79
    • 84858332163 scopus 로고    scopus 로고
    • Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis
    • Tho, L. M., Libertini, S., Rampling, R., Sansom, O. & Gillespie, D. A. Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. Oncogene 31, 1366-1375 (2012).
    • (2012) Oncogene , vol.31 , pp. 1366-1375
    • Tho, L.M.1    Libertini, S.2    Rampling, R.3    Sansom, O.4    Gillespie, D.A.5
  • 80
    • 84874775434 scopus 로고    scopus 로고
    • Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer
    • Xu, J. et al. Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. Oncogene 32, 976-987 (2013).
    • (2013) Oncogene , vol.32 , pp. 976-987
    • Xu, J.1
  • 81
    • 34547109117 scopus 로고    scopus 로고
    • The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas
    • Verlinden, L. et al. The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas. Cancer Res. 67, 6574-6581 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 6574-6581
    • Verlinden, L.1
  • 82
    • 84892712917 scopus 로고    scopus 로고
    • Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma
    • Xie, Y. et al. Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma. Med. Oncol. 31, 844 (2014).
    • (2014) Med. Oncol. , vol.31 , pp. 844
    • Xie, Y.1
  • 84
    • 0037371056 scopus 로고    scopus 로고
    • Cyclins and cyclin-dependent kinases: Comparative study of hepatocellular carcinoma versus cirrhosis
    • Masaki, T. et al. Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis. Hepatology 37, 534-543 (2003).
    • (2003) Hepatology , vol.37 , pp. 534-543
    • Masaki, T.1
  • 85
    • 77956517283 scopus 로고    scopus 로고
    • In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
    • Mir, S. E. et al. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell 18, 244-257 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 244-257
    • Mir, S.E.1
  • 86
    • 84862185038 scopus 로고    scopus 로고
    • High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: Potential for targeted therapy
    • Magnussen, G. I. et al. High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy. PLoS ONE 7, e38254 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e38254
    • Magnussen, G.I.1
  • 87
    • 84930536727 scopus 로고    scopus 로고
    • WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis
    • Vassilopoulos, A. et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene 34, 3023-3035 (2015).
    • (2015) Oncogene , vol.34 , pp. 3023-3035
    • Vassilopoulos, A.1
  • 88
    • 32244446180 scopus 로고    scopus 로고
    • A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association
    • De Luca, M., Lavia, P. & Guarguaglini, G. A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association. Cell Cycle 5, 296-303 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 296-303
    • De Luca, M.1    Lavia, P.2    Guarguaglini, G.3
  • 89
    • 0034048515 scopus 로고    scopus 로고
    • The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase
    • Roshak, A. K. et al. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell. Signal. 12, 405-411 (2000).
    • (2000) Cell. Signal. , vol.12 , pp. 405-411
    • Roshak, A.K.1
  • 90
    • 4444321565 scopus 로고    scopus 로고
    • Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells
    • van Vugt, M. A., Bras, A. & Medema, R. H. Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol. Cell 15, 799-811 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 799-811
    • Van Vugt, M.A.1    Bras, A.2    Medema, R.H.3
  • 91
    • 0031051218 scopus 로고    scopus 로고
    • Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer
    • Wolf, G. et al. Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer. Oncogene 14, 543-549 (1997).
    • (1997) Oncogene , vol.14 , pp. 543-549
    • Wolf, G.1
  • 92
    • 0033564832 scopus 로고    scopus 로고
    • Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck
    • Knecht, R. et al. Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res. 59, 2794-2797 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 2794-2797
    • Knecht, R.1
  • 93
    • 33646811208 scopus 로고    scopus 로고
    • Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma
    • Kanaji, S. et al. Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma. Oncology 70, 126-133 (2006).
    • (2006) Oncology , vol.70 , pp. 126-133
    • Kanaji, S.1
  • 94
    • 0033778278 scopus 로고    scopus 로고
    • Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines
    • Simizu, S. & Osada, H. Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. Nat. Cell Biol. 2, 852-854 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 852-854
    • Simizu, S.1    Osada, H.2
  • 95
    • 55849147330 scopus 로고    scopus 로고
    • Polo-like kinase 1 is essential for early embryonic development and tumor suppression
    • Lu, L. Y. et al. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol.-Cell. Biol. 28, 6870-6876 (2008).
    • (2008) Mol.-Cell. Biol. , vol.28 , pp. 6870-6876
    • Lu, L.Y.1
  • 96
    • 46249084662 scopus 로고    scopus 로고
    • Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry
    • Seki, A., Coppinger, J. A., Jang, C. Y., Yates, J. R. & Fang, G. Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry. Science 320, 1655-1658 (2008).
    • (2008) Science , vol.320 , pp. 1655-1658
    • Seki, A.1    Coppinger, J.A.2    Jang, C.Y.3    Yates, J.R.4    Fang, G.5
  • 97
    • 51349144633 scopus 로고    scopus 로고
    • Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
    • Macurek, L. et al. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455, 119-123 (2008).
    • (2008) Nature , vol.455 , pp. 119-123
    • Macurek, L.1
  • 98
    • 57849107571 scopus 로고    scopus 로고
    • Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
    • Otto, T. et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell 15, 67-78 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 67-78
    • Otto, T.1
  • 99
    • 18644380150 scopus 로고    scopus 로고
    • Roles of Aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells
    • Marumoto, T. et al. Roles of Aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes Cells 7, 1173-1182 (2002).
    • (2002) Genes Cells , vol.7 , pp. 1173-1182
    • Marumoto, T.1
  • 100
    • 0037586498 scopus 로고    scopus 로고
    • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    • Anand, S., Penrhyn-Lowe, S. & Venkitaraman, A. R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3, 51-62 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 51-62
    • Anand, S.1    Penrhyn-Lowe, S.2    Venkitaraman, A.R.3
  • 101
    • 0037084163 scopus 로고    scopus 로고
    • Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells
    • Meraldi, P., Honda, R. & Nigg, E. A. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J. 21, 483-492 (2002).
    • (2002) EMBO J. , vol.21 , pp. 483-492
    • Meraldi, P.1    Honda, R.2    Nigg, E.A.3
  • 102
    • 84944567863 scopus 로고    scopus 로고
    • Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development
    • Gonzalez-Loyola, A. et al. Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35, 3566-3578 (2015).
    • (2015) Mol. Cell. Biol. , vol.35 , pp. 3566-3578
    • Gonzalez-Loyola, A.1
  • 103
    • 84873048485 scopus 로고    scopus 로고
    • Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer
    • Mosquera, J. M. et al. Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia 15, 1-10 (2013).
    • (2013) Neoplasia , vol.15 , pp. 1-10
    • Mosquera, J.M.1
  • 104
    • 76649119826 scopus 로고    scopus 로고
    • Aurora-A gene is frequently amplified in basal-like breast cancer
    • Staff, S., Isola, J., Jumppanen, M. & Tanner, M. Aurora-A gene is frequently amplified in basal-like breast cancer. Oncol. Rep. 23, 307-312 (2010).
    • (2010) Oncol. Rep. , vol.23 , pp. 307-312
    • Staff, S.1    Isola, J.2    Jumppanen, M.3    Tanner, M.4
  • 105
    • 1642361744 scopus 로고    scopus 로고
    • Overexpression and amplification of Aurora-A in hepatocellular carcinoma
    • Jeng, Y. M., Peng, S. Y., Lin, C. Y. & Hsu, H. C. Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin. Cancer Res. 10, 2065-2071 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2065-2071
    • Jeng, Y.M.1    Peng, S.Y.2    Lin, C.Y.3    Hsu, H.C.4
  • 106
    • 84892516363 scopus 로고    scopus 로고
    • Proteins related to the spindle and checkpoint mitotic emphasize the different pathogenesis of hypoplastic MDS
    • Heredia, F. F. et al. Proteins related to the spindle and checkpoint mitotic emphasize the different pathogenesis of hypoplastic MDS. Leuk. Res. 38, 218-224 (2014).
    • (2014) Leuk. Res. , vol.38 , pp. 218-224
    • Heredia, F.F.1
  • 107
    • 33751085368 scopus 로고    scopus 로고
    • Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation
    • Wang, X. et al. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 25, 7148-7158 (2006).
    • (2006) Oncogene , vol.25 , pp. 7148-7158
    • Wang, X.1
  • 108
    • 57649119787 scopus 로고    scopus 로고
    • Aurora a is essential for early embryonic development and tumor suppression
    • Lu, L. Y. et al. Aurora a is essential for early embryonic development and tumor suppression. J. Biol. Chem. 283, 31785-31790 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 31785-31790
    • Lu, L.Y.1
  • 109
    • 79958098477 scopus 로고    scopus 로고
    • Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development
    • Fernandez-Miranda, G. et al. Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development 138, 2661-2672 (2011).
    • (2011) Development , vol.138 , pp. 2661-2672
    • Fernandez-Miranda, G.1
  • 110
    • 2342635919 scopus 로고    scopus 로고
    • Cell death by mitotic catastrophe: A molecular definition
    • Castedo, M. et al. Cell death by mitotic catastrophe: a molecular definition. Oncogene 23, 2825-2837 (2004).
    • (2004) Oncogene , vol.23 , pp. 2825-2837
    • Castedo, M.1
  • 111
    • 0026452974 scopus 로고
    • Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
    • Kaur, G. et al. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J. Natl Cancer Inst. 84, 1736-1740 (1992).
    • (1992) J. Natl Cancer Inst. , vol.84 , pp. 1736-1740
    • Kaur, G.1
  • 112
    • 0032055497 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts
    • Arguello, F. et al. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts. Blood 91, 2482-2490 (1998).
    • (1998) Blood , vol.91 , pp. 2482-2490
    • Arguello, F.1
  • 113
    • 0034665961 scopus 로고    scopus 로고
    • Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
    • Chao, S. H. et al. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J. Biol. Chem. 275, 28345-28348 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 28345-28348
    • Chao, S.H.1
  • 114
    • 73349096649 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease
    • Lin, T. S. et al. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J. Clin. Oncol. 27, 6012-6018 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 6012-6018
    • Lin, T.S.1
  • 115
    • 84928089301 scopus 로고    scopus 로고
    • Final results of EFC6663: A multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia
    • Lanasa, M. C. et al. Final results of EFC6663: a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia. Leuk. Res. 39, 495-500 (2015).
    • (2015) Leuk. Res. , vol.39 , pp. 495-500
    • Lanasa, M.C.1
  • 116
    • 85010862584 scopus 로고    scopus 로고
    • Phase i study of sapacitabine and seliciclib in patients with advanced solid tumors
    • abstr. 2503
    • Tolaney, S. M. et al. Phase I study of sapacitabine and seliciclib in patients with advanced solid tumors. J. Clin. Oncol. 34 (Suppl.), abstr. 2503 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Tolaney, S.M.1
  • 117
    • 77955485400 scopus 로고    scopus 로고
    • Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor
    • Parry, D. et al. Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol. Cancer Ther. 9, 2344-2353 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2344-2353
    • Parry, D.1
  • 118
    • 80053398390 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
    • Feldmann, G. et al. Cyclin-dependent kinase inhibitor dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol. Ther. 12, 598-609 (2011).
    • (2011) Cancer Biol. Ther. , vol.12 , pp. 598-609
    • Feldmann, G.1
  • 119
    • 84863299833 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program
    • Gorlick, R. et al. Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program. Pediatr. Blood Cancer 59, 1266-1274 (2012).
    • (2012) Pediatr. Blood Cancer , vol.59 , pp. 1266-1274
    • Gorlick, R.1
  • 120
    • 84875082183 scopus 로고    scopus 로고
    • The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling
    • Desai, B. M. et al. The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling. PLoS ONE 8, e59588 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e59588
    • Desai, B.M.1
  • 121
    • 84892865722 scopus 로고    scopus 로고
    • Randomized phase 2 study of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus erlotinib in patients with non-small cell lung cancer
    • Stephenson, J. J. et al. Randomized phase 2 study of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus erlotinib in patients with non-small cell lung cancer. Lung Cancer 83, 219-223 (2014).
    • (2014) Lung Cancer , vol.83 , pp. 219-223
    • Stephenson, J.J.1
  • 122
    • 84885373834 scopus 로고    scopus 로고
    • Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib (SCH 727965) in acute leukemias
    • Gojo, I. et al. Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib (SCH 727965) in acute leukemias. Cancer Chemother. Pharmacol. 72, 897-908 (2013).
    • (2013) Cancer Chemother. Pharmacol. , vol.72 , pp. 897-908
    • Gojo, I.1
  • 123
    • 84899988247 scopus 로고    scopus 로고
    • Randomized phase II trial of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus capecitabine in patients with advanced breast cancer
    • Mita, M. M. et al. Randomized phase II trial of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus capecitabine in patients with advanced breast cancer. Clin. Breast Cancer 14, 169-176 (2014).
    • (2014) Clin. Breast Cancer , vol.14 , pp. 169-176
    • Mita, M.M.1
  • 124
    • 84944443369 scopus 로고    scopus 로고
    • Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma
    • Kumar, S. K. et al. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma. Blood 125, 443-448 (2015).
    • (2015) Blood , vol.125 , pp. 443-448
    • Kumar, S.K.1
  • 125
    • 84937022691 scopus 로고    scopus 로고
    • Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia
    • Flynn, J. et al. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia 29, 1524-1529 (2015).
    • (2015) Leukemia , vol.29 , pp. 1524-1529
    • Flynn, J.1
  • 126
    • 84940196763 scopus 로고    scopus 로고
    • Combined inhibition of cyclin-dependent kinases (dinaciclib) and AKT (MK-2206) blocks pancreatic tumor growth and metastases in patient-derived xenograft models
    • Hu, C. et al. Combined inhibition of cyclin-dependent kinases (dinaciclib) and AKT (MK-2206) blocks pancreatic tumor growth and metastases in patient-derived xenograft models. Mol. Cancer Ther. 14, 1532-1539 (2015).
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 1532-1539
    • Hu, C.1
  • 127
    • 84964459612 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT01783171 (2016).
    • (2016) ClinicalTrials.gov
  • 128
    • 84930571469 scopus 로고    scopus 로고
    • CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo
    • Gregory, G. P. et al. CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo. Leukemia 29, 1437-1441 (2015).
    • (2015) Leukemia , vol.29 , pp. 1437-1441
    • Gregory, G.P.1
  • 129
    • 84964459612 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT01676753 (2016).
    • (2016) ClinicalTrials.gov
  • 130
    • 84962440911 scopus 로고    scopus 로고
    • Targeting CDK4 and CDK6: From discovery to therapy
    • Sherr, C. J., Beach, D. & Shapiro, G. I. Targeting CDK4 and CDK6: from discovery to therapy. Cancer Discov. 6, 353-367 (2016).
    • (2016) Cancer Discov. , vol.6 , pp. 353-367
    • Sherr, C.J.1    Beach, D.2    Shapiro, G.I.3
  • 131
    • 84906673584 scopus 로고    scopus 로고
    • The cancer drug that almost wasn't
    • Garber, K. The cancer drug that almost wasn't. Science 345, 865-867 (2014).
    • (2014) Science , vol.345 , pp. 865-867
    • Garber, K.1
  • 132
    • 9444228344 scopus 로고    scopus 로고
    • Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
    • Fry, D. W. et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol. Cancer Ther. 3, 1427-1438 (2004).
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1427-1438
    • Fry, D.W.1
  • 133
    • 77954757207 scopus 로고    scopus 로고
    • Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure
    • Dean, J. L., Thangavel, C., McClendon, A. K., Reed, C. A. & Knudsen, E. S. Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure. Oncogene 29, 4018-4032 (2010).
    • (2010) Oncogene , vol.29 , pp. 4018-4032
    • Dean, J.L.1    Thangavel, C.2    McClendon, A.K.3    Reed, C.A.4    Knudsen, E.S.5
  • 134
    • 33745076446 scopus 로고    scopus 로고
    • Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells
    • Saab, R. et al. Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells. Mol. Cancer Ther. 5, 1299-1308 (2006).
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1299-1308
    • Saab, R.1
  • 135
    • 33747872306 scopus 로고    scopus 로고
    • A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
    • Baughn, L. B. et al. A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6. Cancer Res. 66, 7661-7667 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7661-7667
    • Baughn, L.B.1
  • 136
    • 34548838818 scopus 로고    scopus 로고
    • Pharmacologic inhibition of CDK4/6: Mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia
    • Wang, L. et al. Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia. Blood 110, 2075-2083 (2007).
    • (2007) Blood , vol.110 , pp. 2075-2083
    • Wang, L.1
  • 137
    • 84958153039 scopus 로고    scopus 로고
    • Specific antileukemic activity of PD0332991, a CDK4/6 inhibitor, against Philadelphia chromosome-positive lymphoid leukemia
    • Nemoto, A. et al. Specific antileukemic activity of PD0332991, a CDK4/6 inhibitor, against Philadelphia chromosome-positive lymphoid leukemia. Mol. Cancer Ther. 15, 94-105 (2016).
    • (2016) Mol. Cancer Ther. , vol.15 , pp. 94-105
    • Nemoto, A.1
  • 138
    • 84942098072 scopus 로고    scopus 로고
    • CDKN2A/p16 loss implicates CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans
    • Eilers, G. et al. CDKN2A/p16 loss implicates CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans. Mol. Cancer Ther. 14, 1346-1353 (2015).
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 1346-1353
    • Eilers, G.1
  • 139
    • 77951082119 scopus 로고    scopus 로고
    • Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
    • Michaud, K. et al. Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res. 70, 3228-3238 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3228-3238
    • Michaud, K.1
  • 140
    • 76049104235 scopus 로고    scopus 로고
    • PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
    • Finn, R. S. et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 11, R77 (2009).
    • (2009) Breast Cancer Res. , vol.11 , pp. R77
    • Finn, R.S.1
  • 141
    • 79952710710 scopus 로고    scopus 로고
    • Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer
    • Konecny, G. E. et al. Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer. Clin. Cancer Res. 17, 1591-1602 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1591-1602
    • Konecny, G.E.1
  • 142
    • 84883279733 scopus 로고    scopus 로고
    • PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity
    • Logan, J. E. et al. PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity. Anticancer Res. 33, 2997-3004 (2013).
    • (2013) Anticancer Res. , vol.33 , pp. 2997-3004
    • Logan, J.E.1
  • 143
    • 84907200254 scopus 로고    scopus 로고
    • Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and. In vivo
    • Zhang, Y. X. et al. Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo. Mol. Cancer Ther. 13, 2184-2193 (2014).
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 2184-2193
    • Zhang, Y.X.1
  • 144
    • 84862877673 scopus 로고    scopus 로고
    • P16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells
    • Cen, L. et al. p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol. 14, 870-881 (2012).
    • (2012) Neuro Oncol. , vol.14 , pp. 870-881
    • Cen, L.1
  • 145
    • 84947241171 scopus 로고    scopus 로고
    • CDK4 amplification reduces sensitivity to CDK4/6 inhibition in fusion-positive rhabdomyosarcoma
    • Olanich, M. E. et al. CDK4 amplification reduces sensitivity to CDK4/6 inhibition in fusion-positive rhabdomyosarcoma. Clin. Cancer Res. 21, 4947-4959 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 4947-4959
    • Olanich, M.E.1
  • 146
    • 79960100823 scopus 로고    scopus 로고
    • Therapeutically activating RB: Reestablishing cell cycle control in endocrine therapy-resistant breast cancer
    • Thangavel, C. et al. Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr. Relat. Cancer 18, 333-345 (2011).
    • (2011) Endocr. Relat. Cancer , vol.18 , pp. 333-345
    • Thangavel, C.1
  • 147
    • 84928403772 scopus 로고    scopus 로고
    • MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition
    • Kovatcheva, M. et al. MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget 6, 8226-8243 (2015).
    • (2015) Oncotarget , vol.6 , pp. 8226-8243
    • Kovatcheva, M.1
  • 148
    • 84873638532 scopus 로고    scopus 로고
    • Aging cellular senescence, and cancer
    • Campisi, J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 75, 685-705 (2013).
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 685-705
    • Campisi, J.1
  • 149
    • 84861210266 scopus 로고    scopus 로고
    • Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma
    • Leonard, J. P. et al. Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood 119, 4597-4607 (2012).
    • (2012) Blood , vol.119 , pp. 4597-4607
    • Leonard, J.P.1
  • 150
    • 84928277686 scopus 로고    scopus 로고
    • Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors
    • Vaughn, D. J. et al. Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors. Cancer 121, 1463-1468 (2015).
    • (2015) Cancer , vol.121 , pp. 1463-1468
    • Vaughn, D.J.1
  • 151
    • 84975684804 scopus 로고    scopus 로고
    • A phase II clinical trial of the CDK 4/6 inhibitor palbociclib (PD 0332991) in previously treated, advanced non-small cell lung cancer (NSCLC) patients with inactivated CDKN2A
    • abstr. 8077
    • Gopalan, P. K. et al. A phase II clinical trial of the CDK 4/6 inhibitor palbociclib (PD 0332991) in previously treated, advanced non-small cell lung cancer (NSCLC) patients with inactivated CDKN2A. J. Clin. Oncol. 32 (Suppl. 5s), abstr. 8077 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Gopalan, P.K.1
  • 152
    • 84880695940 scopus 로고    scopus 로고
    • Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma
    • Dickson, M. A. et al. Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma. J. Clin. Oncol. 31, 2024-2028 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 2024-2028
    • Dickson, M.A.1
  • 153
    • 33750289088 scopus 로고    scopus 로고
    • Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes
    • Sicinska, E. et al. Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes. Mol. Cell. Biol. 26, 8052-8060 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 8052-8060
    • Sicinska, E.1
  • 154
    • 84922369296 scopus 로고    scopus 로고
    • The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): A randomised phase 2 study
    • Finn, R. S. et al. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol. 16, 25-35 (2015).
    • (2015) Lancet Oncol. , vol.16 , pp. 25-35
    • Finn, R.S.1
  • 155
    • 84947204419 scopus 로고    scopus 로고
    • FDA approval: Palbociclib for the treatment of postmenopausal patients with estrogen receptor-positive, HER2-negative metastatic breast cancer
    • Beaver, J. A. et al. FDA approval: palbociclib for the treatment of postmenopausal patients with estrogen receptor-positive, HER2-negative metastatic breast cancer. Clin. Cancer Res. 21, 4760-4766 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 4760-4766
    • Beaver, J.A.1
  • 156
    • 84937042338 scopus 로고    scopus 로고
    • Palbociclib in hormone-receptor-positive advanced breast cancer
    • Turner, N. C. et al. Palbociclib in hormone-receptor-positive advanced breast cancer. N. Engl. J. Med. 373, 209-219 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 209-219
    • Turner, N.C.1
  • 157
    • 84959316268 scopus 로고    scopus 로고
    • Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): Final analysis of the multicentre, double-blind, phase 3 randomised controlled trial
    • Cristofanilli, M. et al. Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol. 17, 425-439 (2016).
    • (2016) Lancet Oncol. , vol.17 , pp. 425-439
    • Cristofanilli, M.1
  • 158
    • 85010883213 scopus 로고    scopus 로고
    • Palbociclib (IBRANCE Capsules)
    • US Food and Drug Administration.
    • US Food and Drug Administration. Palbociclib (IBRANCE Capsules). FDA http://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm487080.htm (2016).
    • (2016) FDA
  • 159
    • 84928318557 scopus 로고    scopus 로고
    • CDK 4/6 inhibitor palbociclib (PD0332991) in Rb+ advanced breast cancer: Phase II activity, safety, and predictive biomarker assessment
    • DeMichele, A. et al. CDK 4/6 inhibitor palbociclib (PD0332991) in Rb+ advanced breast cancer: phase II activity, safety, and predictive biomarker assessment. Clin. Cancer Res. 21, 995-1001 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 995-1001
    • DeMichele, A.1
  • 160
    • 84959852003 scopus 로고    scopus 로고
    • The history and future of targeting cyclin-dependent kinases in cancer therapy
    • Asghar, U., Witkiewicz, A. K., Turner, N. C. & Knudsen, E. S. The history and future of targeting cyclin-dependent kinases in cancer therapy. Nat. Rev. Drug Discov. 14, 130-146 (2015).
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 130-146
    • Asghar, U.1    Witkiewicz, A.K.2    Turner, N.C.3    Knudsen, E.S.4
  • 161
    • 84888082787 scopus 로고    scopus 로고
    • Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma
    • Rader, J. et al. Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 19, 6173-6182 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 6173-6182
    • Rader, J.1
  • 162
    • 84945157565 scopus 로고    scopus 로고
    • Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma
    • Kennedy, A. L. et al. Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma. Oncotarget 6, 30178-30193 (2015).
    • (2015) Oncotarget , vol.6 , pp. 30178-30193
    • Kennedy, A.L.1
  • 163
    • 84905669286 scopus 로고    scopus 로고
    • A phase i study of the single-agent CDK4/6 inhibitor LEE011 in pts with advanced solid tumors and lymphomas
    • abstr. 2528
    • Infante, J. R. et al. A phase I study of the single-agent CDK4/6 inhibitor LEE011 in pts with advanced solid tumors and lymphomas. J. Clin. Oncol. 32 (Suppl. 5s), abstr. 2528 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Infante, J.R.1
  • 164
    • 84939192527 scopus 로고    scopus 로고
    • Ph IB study of LEE011 and BYL719 in combination with letrozole in ER+, HER2-breast cancer
    • abstr. 143
    • Munster, P. N. et al. Ph IB study of LEE011 and BYL719 in combination with letrozole in ER+, HER2-breast cancer. J. Clin. Oncol. 32 (Suppl. 26), abstr. 143 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Munster, P.N.1
  • 165
    • 84930696140 scopus 로고    scopus 로고
    • Preclinical characterization of the CDK4/6 inhibitor LY2835219: In-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine
    • Gelbert, L. M. et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest. New Drugs 32, 825-837 (2014).
    • (2014) Invest. New Drugs , vol.32 , pp. 825-837
    • Gelbert, L.M.1
  • 166
    • 84925604287 scopus 로고    scopus 로고
    • The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation
    • Yadav, V. et al. The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol. Cancer Ther. 13, 2253-2263 (2014).
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 2253-2263
    • Yadav, V.1
  • 167
    • 84940421447 scopus 로고    scopus 로고
    • Brain exposure of two selective dual CDK4 and CDK6 inhibitors and the antitumor activity of CDK4 and CDK6 inhibition in combination with temozolomide in an intracranial glioblastoma xenograft
    • Raub, T. J. et al. Brain exposure of two selective dual CDK4 and CDK6 inhibitors and the antitumor activity of CDK4 and CDK6 inhibition in combination with temozolomide in an intracranial glioblastoma xenograft. Drug Metab. Dispos. 43, 1360-1371 (2015).
    • (2015) Drug Metab. Dispos. , vol.43 , pp. 1360-1371
    • Raub, T.J.1
  • 168
    • 84891011530 scopus 로고    scopus 로고
    • A first-in-human phase i study of the CDK4/6 inhibitor, LY2835219, for patients with advanced cancer
    • abstr. 2500
    • Shapiro, G. et al. A first-in-human phase I study of the CDK4/6 inhibitor, LY2835219, for patients with advanced cancer. J. Clin. Oncol. 31 (Suppl.), abstr. 2500 (2013).
    • (2013) J. Clin. Oncol. , vol.31
    • Shapiro, G.1
  • 169
    • 84947336844 scopus 로고    scopus 로고
    • Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with non-small cell lung cancer
    • abstr. 8026
    • Goldman, J. W. et al. Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with non-small cell lung cancer. J. Clin. Oncol. 32 (Suppl. 5s), abstr. 8026 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Goldman, J.W.1
  • 170
    • 84923794403 scopus 로고    scopus 로고
    • LY2835219, a novel cell cycle inhibitor selective for CDK4/6, in combination with fulvestrant for patients with hormone receptor positive (HR+) metastatic breast cancer
    • abstr. 534
    • Patnaik, A. et al. LY2835219, a novel cell cycle inhibitor selective for CDK4/6, in combination with fulvestrant for patients with hormone receptor positive (HR+) metastatic breast cancer. J. Clin. Oncol. 32 (Suppl. 5s), abstr. 534 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Patnaik, A.1
  • 171
    • 85010841772 scopus 로고    scopus 로고
    • FDA's breakthrough therapy designation to abemaciclib for breast cancer
    • DiGiulio, S. FDA's breakthrough therapy designation to abemaciclib for breast cancer. Wolters Kluwer Health http://journals.lww.com/oncology-times/blog/fdaactionsandupdates/pages/post.aspx?PostID=119 (2015).
    • (2015) Wolters Kluwer Health
    • DiGiulio, S.1
  • 172
    • 84952977711 scopus 로고    scopus 로고
    • A phase Ib study of abemaciclib with therapies for metastatic breast cancer
    • abstr. 522
    • Tolaney, S. M. et al. A phase Ib study of abemaciclib with therapies for metastatic breast cancer. J. Clin. Oncol. 33 (Suppl.), abstr. 522 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Tolaney, S.M.1
  • 173
    • 84942923804 scopus 로고    scopus 로고
    • A phase i trial of palbociclib and paclitaxel in metastatic breast cancer
    • abstr. 527
    • Clark, A. S. et al. A phase I trial of palbociclib and paclitaxel in metastatic breast cancer. J. Clin. Oncol. 32 (Suppl. 5s), abstr. 527 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Clark, A.S.1
  • 174
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
    • Kwong, L. N. et al. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat. Med. 18, 1503-1510 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1503-1510
    • Kwong, L.N.1
  • 175
    • 84912110744 scopus 로고    scopus 로고
    • A phase 1b/2 study of LEE011 in combination with binimetinib (MEK162) in patients with NRAS-mutant melanoma: Early encouraging clinical activity
    • abstr. 9009
    • Sosman, J. A. et al. A phase 1b/2 study of LEE011 in combination with binimetinib (MEK162) in patients with NRAS-mutant melanoma: early encouraging clinical activity. J. Clin. Oncol. 32 (Suppl. 5s), abstr. 9009 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Sosman, J.A.1
  • 176
    • 84904259645 scopus 로고    scopus 로고
    • CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors
    • Vora, S. R. et al. CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors. Cancer Cell 26, 136-149 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 136-149
    • Vora, S.R.1
  • 177
    • 84926023132 scopus 로고    scopus 로고
    • Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer
    • abstr. 535
    • Bardia, A. et al. Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer. J. Clin. Oncol. 32 (Suppl. 5s), abstr. 535 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Bardia, A.1
  • 178
    • 84859079523 scopus 로고    scopus 로고
    • Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy
    • Roberts, P. J. et al. Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. J. Natl Cancer Inst. 104, 476-487 (2012).
    • (2012) J. Natl Cancer Inst. , vol.104 , pp. 476-487
    • Roberts, P.J.1
  • 179
    • 84864378859 scopus 로고    scopus 로고
    • CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy
    • McClendon, A. K. et al. CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle 11, 2747-2755 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 2747-2755
    • McClendon, A.K.1
  • 180
    • 77954997865 scopus 로고    scopus 로고
    • Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
    • Johnson, S. M. et al. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. J. Clin. Invest. 120, 2528-2536 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2528-2536
    • Johnson, S.M.1
  • 181
    • 84964459612 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02499770 (2016).
    • (2016) ClinicalTrials.gov
  • 182
    • 79955735344 scopus 로고    scopus 로고
    • Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening
    • Guzi, T. J. et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol. Cancer Ther. 10, 591-602 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 591-602
    • Guzi, T.J.1
  • 183
    • 84856822207 scopus 로고    scopus 로고
    • Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites
    • Montano, R., Chung, I., Garner, K. M., Parry, D. & Eastman, A. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol. Cancer Ther. 11, 427-438 (2012).
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 427-438
    • Montano, R.1    Chung, I.2    Garner, K.M.3    Parry, D.4    Eastman, A.5
  • 184
    • 84866924927 scopus 로고    scopus 로고
    • Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro
    • Schenk, E. L. et al. Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro. Clin. Cancer Res. 18, 5364-5373 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 5364-5373
    • Schenk, E.L.1
  • 185
    • 84927531186 scopus 로고    scopus 로고
    • Phase i dose-escalation trial of checkpoint kinase 1 inhibitor MK-8776 as monotherapy and in combination with gemcitabine in patients with advanced solid tumors
    • Daud, A. I. et al. Phase I dose-escalation trial of checkpoint kinase 1 inhibitor MK-8776 as monotherapy and in combination with gemcitabine in patients with advanced solid tumors. J. Clin. Oncol. 33, 1060-1066 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1060-1066
    • Daud, A.I.1
  • 186
    • 84871234067 scopus 로고    scopus 로고
    • Phase i and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias
    • Karp, J. E. et al. Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias. Clin. Cancer Res. 18, 6723-6731 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6723-6731
    • Karp, J.E.1
  • 187
    • 84964459612 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT01870596 (2016).
    • (2016) ClinicalTrials.gov
  • 188
    • 84942154757 scopus 로고    scopus 로고
    • LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms
    • King, C. et al. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Mol. Cancer Ther. 14, 2004-2013 (2015).
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 2004-2013
    • King, C.1
  • 189
    • 84961625319 scopus 로고    scopus 로고
    • Checkpoint kinase (CHK) 1/2 inhibitor LY2606368 in a phase I, dose-expansion study in patients (pts) with metastatic squamous cell carcinoma (mSCC) of the anus
    • abstr. 3520
    • Bendell, J. C. et al. Checkpoint kinase (CHK) 1/2 inhibitor LY2606368 in a phase I, dose-expansion study in patients (pts) with metastatic squamous cell carcinoma (mSCC) of the anus. J. Clin. Oncol. 33 (Suppl.), abstr. 3520 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Bendell, J.C.1
  • 190
    • 70949083026 scopus 로고    scopus 로고
    • Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
    • Hirai, H. et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol. Cancer Ther. 8, 2992-3000 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2992-3000
    • Hirai, H.1
  • 191
    • 77953711939 scopus 로고    scopus 로고
    • MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil
    • Hirai, H. et al. MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil. Cancer Biol. Ther. 9, 514-522 (2010).
    • (2010) Cancer Biol. Ther. , vol.9 , pp. 514-522
    • Hirai, H.1
  • 192
    • 80052491760 scopus 로고    scopus 로고
    • MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells
    • Bridges, K. A. et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin. Cancer Res. 17, 5638-5648 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5638-5648
    • Bridges, K.A.1
  • 193
    • 79955492036 scopus 로고    scopus 로고
    • MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
    • Rajeshkumar, N. V. et al. MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts. Clin. Cancer Res. 17, 2799-2806 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2799-2806
    • Rajeshkumar, N.V.1
  • 194
    • 84882253419 scopus 로고    scopus 로고
    • Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy
    • Guertin, A. D. et al. Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy. Mol. Cancer Ther. 12, 1442-1452 (2013).
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 1442-1452
    • Guertin, A.D.1
  • 195
    • 84890471920 scopus 로고    scopus 로고
    • Inhibition of Wee1 sensitizes cancer cells to antimetabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality
    • Van Linden, A. A. et al. Inhibition of Wee1 sensitizes cancer cells to antimetabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality. Mol. Cancer Ther. 12, 2675-2684 (2013).
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 2675-2684
    • Van Linden, A.A.1
  • 196
    • 84894228414 scopus 로고    scopus 로고
    • Targeting Wee1 for the treatment of pediatric high-grade gliomas
    • Mueller, S. et al. Targeting Wee1 for the treatment of pediatric high-grade gliomas. Neuro Oncol. 16, 352-360 (2014).
    • (2014) Neuro Oncol. , vol.16 , pp. 352-360
    • Mueller, S.1
  • 197
    • 84908281599 scopus 로고    scopus 로고
    • Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer
    • Karnak, D. et al. Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer. Clin. Cancer Res. 20, 5085-5096 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 5085-5096
    • Karnak, D.1
  • 198
    • 84927618199 scopus 로고    scopus 로고
    • A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations
    • Zhou, L. et al. A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations. Leukemia 29, 807-818 (2015).
    • (2015) Leukemia , vol.29 , pp. 807-818
    • Zhou, L.1
  • 199
    • 84919494726 scopus 로고    scopus 로고
    • Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer
    • Wang, G. et al. Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer. Cancer Lett. 356, 656-668 (2015).
    • (2015) Cancer Lett. , vol.356 , pp. 656-668
    • Wang, G.1
  • 200
    • 84920641027 scopus 로고    scopus 로고
    • Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies
    • Weisberg, E. et al. Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. Leukemia 29, 27-37 (2015).
    • (2015) Leukemia , vol.29 , pp. 27-37
    • Weisberg, E.1
  • 201
    • 80655141261 scopus 로고    scopus 로고
    • Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation
    • Davies, K. D. et al. Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation. Cancer Biol. Ther. 12, 788-796 (2011).
    • (2011) Cancer Biol. Ther. , vol.12 , pp. 788-796
    • Davies, K.D.1
  • 202
    • 84872533885 scopus 로고    scopus 로고
    • Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma
    • Russell, M. R. et al. Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma. Cancer Res. 73, 776-784 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 776-784
    • Russell, M.R.1
  • 203
    • 85007146303 scopus 로고    scopus 로고
    • Phase II study with Wee1 inhibitor AZD1775 plus carboplatin in patients with p53 mutated ovarian cancer refractory or resistant (<3 months) to standard first line therapy
    • abstr. 2507
    • Leijen, S. et al. Phase II study with Wee1 inhibitor AZD1775 plus carboplatin in patients with p53 mutated ovarian cancer refractory or resistant (<3 months) to standard first line therapy. J. Clin. Oncol. 33 (Suppl.), abstr. 2507 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Leijen, S.1
  • 204
    • 84942129079 scopus 로고    scopus 로고
    • An international, biomarker-directed, randomized, phase II trial of AZD1775 plus paclitaxel and carboplatin (P/C) for the treatment of women with platinum-sensitive, TP53-mutant ovarian cancer
    • abstr.5506
    • Oza, A. M. et al. An international, biomarker-directed, randomized, phase II trial of AZD1775 plus paclitaxel and carboplatin (P/C) for the treatment of women with platinum-sensitive, TP53-mutant ovarian cancer. J. Clin. Oncol. 33 (Suppl.), abstr. 5506 (2015).
    • (2015) J. Clin. Oncol.
    • Oza, A.M.1
  • 205
    • 17644368237 scopus 로고    scopus 로고
    • ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
    • Gumireddy, K. et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell 7, 275-286 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 275-286
    • Gumireddy, K.1
  • 206
    • 84885571008 scopus 로고    scopus 로고
    • The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas
    • Anderson, R. T. et al. The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. Mol. Cancer Ther. 12, 1994-2005 (2013).
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 1994-2005
    • Anderson, R.T.1
  • 207
    • 84897059196 scopus 로고    scopus 로고
    • Rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma. in vitro and in vivo
    • Agoni, L. et al. Rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma. in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys. 88, 1180-1187 (2014).
    • (2014) Int. J. Radiat. Oncol. Biol. Phys. , vol.88 , pp. 1180-1187
    • Agoni, L.1
  • 208
    • 84930900277 scopus 로고    scopus 로고
    • Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy
    • Silverman, L. R. et al. Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy. Hematol. Oncol. 33, 57-66 (2015).
    • (2015) Hematol. Oncol. , vol.33 , pp. 57-66
    • Silverman, L.R.1
  • 209
    • 85010850731 scopus 로고    scopus 로고
    • Overall survival (OS) and baseline disease characteristics in MDS patients with primary HMA failure in a randomized, controlled, phase III study of rigosertib
    • abstr. e18079
    • Fenaux, P. et al. Overall survival (OS) and baseline disease characteristics in MDS patients with primary HMA failure in a randomized, controlled, phase III study of rigosertib. J. Clin. Oncol. 33 (Suppl.), abstr. e18079 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Fenaux, P.1
  • 210
    • 85010907558 scopus 로고    scopus 로고
    • Prognostic and predictive value of IPSS-R in assessing overall survival (OS) in a phase III study of rigosertib in second-line higher-risk (HR) MDS patients
    • abstr. 7092
    • Silverman, L. R. et al. Prognostic and predictive value of IPSS-R in assessing overall survival (OS) in a phase III study of rigosertib in second-line higher-risk (HR) MDS patients. J. Clin. Oncol. 33 (Suppl.), abstr. 7092 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Silverman, L.R.1
  • 211
    • 65649105075 scopus 로고    scopus 로고
    • BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity
    • Rudolph, D. et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin. Cancer Res. 15, 3094-3102 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3094-3102
    • Rudolph, D.1
  • 212
    • 84904404354 scopus 로고    scopus 로고
    • Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia
    • Sparta, A. M. et al. Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia. Cell Cycle 13, 2237-2247 (2014).
    • (2014) Cell Cycle , vol.13 , pp. 2237-2247
    • Sparta, A.M.1
  • 213
    • 84891670915 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program
    • Gorlick, R. et al. Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 61, 158-164 (2014).
    • (2014) Pediatr. Blood Cancer , vol.61 , pp. 158-164
    • Gorlick, R.1
  • 214
    • 84922362926 scopus 로고    scopus 로고
    • Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia
    • Rudolph, D. et al. Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia. J. Pharmacol. Exp. Ther. 352, 579-589 (2015).
    • (2015) J. Pharmacol. Exp. Ther. , vol.352 , pp. 579-589
    • Rudolph, D.1
  • 215
    • 84920983171 scopus 로고    scopus 로고
    • Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer
    • Bhola, N. E. et al. Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer. Cancer Res. 75, 405-414 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 405-414
    • Bhola, N.E.1
  • 216
    • 84947040545 scopus 로고    scopus 로고
    • Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs
    • Hugle, M., Belz, K. & Fulda, S. Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs. Cell Death Differ. 22, 1946-1956 (2015).
    • (2015) Cell Death Differ. , vol.22 , pp. 1946-1956
    • Hugle, M.1    Belz, K.2    Fulda, S.3
  • 217
    • 84907300532 scopus 로고    scopus 로고
    • Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy
    • Döhner, H. et al. Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy. Blood 124, 1426-1433 (2014).
    • (2014) Blood , vol.124 , pp. 1426-1433
    • Döhner, H.1
  • 218
    • 84964325488 scopus 로고    scopus 로고
    • Volasertib versus chemotherapy in platinum-resistant or -refractory ovarian cancer: A randomized Phase II Groupe des Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire Study
    • Pujade-Lauraine, E. et al. Volasertib versus chemotherapy in platinum-resistant or -refractory ovarian cancer: a randomized Phase II Groupe des Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire Study. J. Clin. Oncol. 34, 706-713 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 706-713
    • Pujade-Lauraine, E.1
  • 219
    • 84899409111 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 trial of the Polo-like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer
    • Stadler, W. M. et al. An open-label, single-arm, phase 2 trial of the Polo-like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer. Cancer 120, 976-982 (2014).
    • (2014) Cancer , vol.120 , pp. 976-982
    • Stadler, W.M.1
  • 220
    • 84944353628 scopus 로고    scopus 로고
    • A randomized, open-label phase II trial of volasertib as monotherapy and in combination with standard-dose pemetrexed compared with pemetrexed monotherapy in second-line treatment for non-small-cell lung cancer
    • Ellis, P. M. et al. A randomized, open-label phase II trial of volasertib as monotherapy and in combination with standard-dose pemetrexed compared with pemetrexed monotherapy in second-line treatment for non-small-cell lung cancer. Clin. Lung Cancer 16, 457-465 (2015).
    • (2015) Clin. Lung Cancer , vol.16 , pp. 457-465
    • Ellis, P.M.1
  • 221
    • 62649112876 scopus 로고    scopus 로고
    • A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
    • Sur, S. et al. A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc. Natl Acad. Sci. USA 106, 3964-3969 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3964-3969
    • Sur, S.1
  • 222
    • 84946405665 scopus 로고    scopus 로고
    • Human ATP-binding cassette transporter ABCB1 confers resistance to volasertib (BI 6727), a selective inhibitor of Polo-like Kinase 1
    • Wu, C. P. et al. Human ATP-binding cassette transporter ABCB1 confers resistance to volasertib (BI 6727), a selective inhibitor of Polo-like Kinase 1. Mol. Pharm. 12, 3885-3895 (2015).
    • (2015) Mol. Pharm. , vol.12 , pp. 3885-3895
    • Wu, C.P.1
  • 223
    • 84055217855 scopus 로고    scopus 로고
    • Characterization of alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays
    • Manfredi, M. G. et al. Characterization of alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. Clin. Cancer Res. 17, 7614-7624 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 7614-7624
    • Manfredi, M.G.1
  • 224
    • 77954686021 scopus 로고    scopus 로고
    • A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
    • Görgün, G. et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood 115, 5202-5213 (2010).
    • (2010) Blood , vol.115 , pp. 5202-5213
    • Görgün, G.1
  • 225
    • 79952565110 scopus 로고    scopus 로고
    • Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma
    • Qi, W. et al. Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma. Biochem. Pharmacol. 81, 881-890 (2011).
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 881-890
    • Qi, W.1
  • 226
    • 77952703733 scopus 로고    scopus 로고
    • Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
    • Maris, J. M. et al. Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). Pediatr. Blood Cancer 55, 26-34 (2010).
    • (2010) Pediatr. Blood Cancer , vol.55 , pp. 26-34
    • Maris, J.M.1
  • 227
    • 84880042989 scopus 로고    scopus 로고
    • Small molecule inhibitors of aurora - A induce proteasomal degradation of N-myc in childhood neuroblastoma
    • Brockmann, M. et al. Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell 24, 75-89 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 75-89
    • Brockmann, M.1
  • 228
    • 84867071565 scopus 로고    scopus 로고
    • Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism
    • Kelly, K. R. et al. Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism. Int. J. Cancer 131, 2693-2703 (2012).
    • (2012) Int. J. Cancer , vol.131 , pp. 2693-2703
    • Kelly, K.R.1
  • 229
    • 84859405151 scopus 로고    scopus 로고
    • The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells
    • Sehdev, V. et al. The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells. Mol. Cancer Ther. 11, 763-774 (2012).
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 763-774
    • Sehdev, V.1
  • 230
    • 84873408412 scopus 로고    scopus 로고
    • The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas
    • Sehdev, V. et al. The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas. Cancer 119, 904-914 (2013).
    • (2013) Cancer , vol.119 , pp. 904-914
    • Sehdev, V.1
  • 231
    • 79957528550 scopus 로고    scopus 로고
    • The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib
    • Kelly, K. R. et al. The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib. J. Cell. Mol. Med. 15, 2057-2070 (2011).
    • (2011) J. Cell. Mol. Med. , vol.15 , pp. 2057-2070
    • Kelly, K.R.1
  • 232
    • 84859816148 scopus 로고    scopus 로고
    • Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non Hodgkin lymphoma
    • Mahadevan, D. et al. Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non Hodgkin lymphoma. Clin. Cancer Res. 18, 2210-2219 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 2210-2219
    • Mahadevan, D.1
  • 233
    • 84902438940 scopus 로고    scopus 로고
    • Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2
    • Mahadevan, D. et al. Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2. PLoS ONE 9, e95184 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e95184
    • Mahadevan, D.1
  • 234
    • 84930620876 scopus 로고    scopus 로고
    • Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models
    • Davis, S. L. et al. Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models. Front. Pharmacol. 6, 120 (2015).
    • (2015) Front. Pharmacol. , vol.6 , pp. 120
    • Davis, S.L.1
  • 235
    • 84958592490 scopus 로고    scopus 로고
    • Exploitation of the apoptosis-primed state of MYCN-amplified neuroblastoma to develop a potent and specific targeted therapy combination
    • Ham, J. et al. Exploitation of the apoptosis-primed state of MYCN-amplified neuroblastoma to develop a potent and specific targeted therapy combination. Cancer Cell 29, 159-172 (2016).
    • (2016) Cancer Cell , vol.29 , pp. 159-172
    • Ham, J.1
  • 236
    • 84954181535 scopus 로고    scopus 로고
    • Combining an aurora kinase inhibitor and a death receptor ligand/agonist antibody triggers apoptosis in melanoma cells and prevents tumor growth in preclinical mouse models
    • Liu, Y. et al. Combining an aurora kinase inhibitor and a death receptor ligand/agonist antibody triggers apoptosis in melanoma cells and prevents tumor growth in preclinical mouse models. Clin. Cancer Res. 21, 5338-5348 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 5338-5348
    • Liu, Y.1
  • 237
    • 84865741266 scopus 로고    scopus 로고
    • Phase i study of aurora A kinase inhibitor MLN8237 in advanced solid tumors: Safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations
    • Dees, E. C. et al. Phase I study of aurora A kinase inhibitor MLN8237 in advanced solid tumors: safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations. Clin. Cancer Res. 18, 4775-4784 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 4775-4784
    • Dees, E.C.1
  • 238
    • 84865681647 scopus 로고    scopus 로고
    • Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
    • Matulonis, U. A. et al. Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. Gynecol. Oncol. 127, 63-69 (2012).
    • (2012) Gynecol. Oncol. , vol.127 , pp. 63-69
    • Matulonis, U.A.1
  • 239
    • 84879047160 scopus 로고    scopus 로고
    • Phase I/II study of weekly paclitaxel with or without MLN8237 (alisertib), an investigational aurora A kinase inhibitor, in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer (OC), or breast cancer (BrC): Phase i results
    • abstr. 5021
    • Falchook, G. S. et al. Phase I/II study of weekly paclitaxel with or without MLN8237 (alisertib), an investigational aurora A kinase inhibitor, in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer (OC), or breast cancer (BrC): phase I results. J. Clin. Oncol. 30 (Suppl.), abstr. 5021 (2012).
    • (2012) J. Clin. Oncol. , vol.30
    • Falchook, G.S.1
  • 240
    • 84933509937 scopus 로고    scopus 로고
    • Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: A five-arm phase 2 study
    • Melichar, B. et al. Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study. Lancet Oncol. 16, 395-405 (2015).
    • (2015) Lancet Oncol. , vol.16 , pp. 395-405
    • Melichar, B.1
  • 241
    • 85010883147 scopus 로고    scopus 로고
    • Phase i trial of the investigational aurora A kinase (AAK) inhibitor MLN8237 (alisertib) in combination with docetaxel (DTX) in patients (pts) with advanced solid tumors, including castration-resistant prostate cancer (CRPC)
    • abstr. 217
    • Sarantopoulos, J. et al. Phase I trial of the investigational aurora A kinase (AAK) inhibitor MLN8237 (alisertib) in combination with docetaxel (DTX) in patients (pts) with advanced solid tumors, including castration-resistant prostate cancer (CRPC). J. Clin. Oncol. 32 (Suppl. 4), abstr. 217 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Sarantopoulos, J.1
  • 242
    • 84978077033 scopus 로고    scopus 로고
    • A phase Ib study of the combination of the aurora kinase inhibitor alisertib (MLN8237) and bortezomib in relapsed multiple myeloma
    • Rosenthal, A. et al. A phase Ib study of the combination of the aurora kinase inhibitor alisertib (MLN8237) and bortezomib in relapsed multiple myeloma. Br. J. Haematol. 174, 323-325 (2016).
    • (2016) Br. J. Haematol. , vol.174 , pp. 323-325
    • Rosenthal, A.1
  • 243
    • 84892916318 scopus 로고    scopus 로고
    • Phase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas
    • Friedberg, J. W. et al. Phase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas. J. Clin. Oncol. 32, 44-50 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 44-50
    • Friedberg, J.W.1
  • 244
    • 84940482034 scopus 로고    scopus 로고
    • Phase II intergroup trial of alisertib in relapsed and refractory peripheral T-cell lymphoma and transformed mycosis fungoides: SWOG 1108
    • Barr, P. M. et al. Phase II intergroup trial of alisertib in relapsed and refractory peripheral T-cell lymphoma and transformed mycosis fungoides: SWOG 1108. J. Clin. Oncol. 33, 2399-2404 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 2399-2404
    • Barr, P.M.1
  • 245
    • 84964459612 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT01829971 (2016).
    • (2016) ClinicalTrials.gov
  • 246
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
    • Loda, M. et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat. Med. 3, 231-234 (1997).
    • (1997) Nat. Med. , vol.3 , pp. 231-234
    • Loda, M.1
  • 247
    • 16944363001 scopus 로고    scopus 로고
    • Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
    • Catzavelos, C. et al. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat. Med. 3, 227-230 (1997).
    • (1997) Nat. Med. , vol.3 , pp. 227-230
    • Catzavelos, C.1
  • 248
    • 0031048716 scopus 로고    scopus 로고
    • Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
    • Porter, P. L. et al. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat. Med. 3, 222-225 (1997).
    • (1997) Nat. Med. , vol.3 , pp. 222-225
    • Porter, P.L.1
  • 249
    • 0030002553 scopus 로고    scopus 로고
    • P27/Kip1 mutation found in breast cancer
    • Spirin, K. S. et al. p27/Kip1 mutation found in breast cancer. Cancer Res. 56, 2400-2404 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 2400-2404
    • Spirin, K.S.1
  • 250
    • 0035817688 scopus 로고    scopus 로고
    • Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
    • Sharpless, N. E. et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413, 86-91 (2001).
    • (2001) Nature , vol.413 , pp. 86-91
    • Sharpless, N.E.1


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