Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

Nature Medicine

Volumn 3, Issue 2, 1997, Pages 231-234

  Loda, Massimo ^a   Cukor, Barry ^a   Tam, Sun W ^b   Lavin, Philip ^c   Fiorentino, Michelangelo ^a   Draetta, Giulio F ^d   Milburn Jessup, J ^a   Pagano, Michele ^b,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GPC Biotech Inc   (United States)

^c Boston Biostatistics Research Foundation   (United States)

^d EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^e NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEASOME; PROTEIN P27;

ADULT; AGED; ARTICLE; CELL CYCLE; COLORECTAL CANCER; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; REGULATORY MECHANISM;

ADENOCARCINOMA; AGED; CELL CYCLE PROTEINS; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYSTEINE ENDOPEPTIDASES; FEMALE; GENES, CDC; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MULTIENZYME COMPLEXES; NEOPLASM STAGING; PROGNOSIS; PROTEASOME ENDOPEPTIDASE COMPLEX; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 0031048236     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0297-231     Document Type: Article

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