The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas

Cancer

Volumn 119, Issue 4, 2013, Pages 904-914

  Sehdev, Vikas ^a   Katsha, Ahmed ^a   Ecsedy, Jeffrey ^b   Zaika, Alexander ^a,c   Belkhiri, Abbes ^a   El Rifai, Wael ^a,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

alisertib; apoptosis; Aurora kinase A; cancer; docetaxel; esophagus; mitosis; stomach

Indexed keywords

ALISERTIB; AURORA A KINASE; DOCETAXEL; MESSENGER RNA; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AURKA GENE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CELL CYCLE ARREST; CELL SURVIVAL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; FEMALE; GASTROINTESTINAL CARCINOMA; GENE; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MONOTHERAPY; MOUSE; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; AZEPINES; CELL CYCLE CHECKPOINTS; CELL SURVIVAL; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; MICE; MICE, NUDE; POLYPLOIDY; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; TAXOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873408412     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27801     Document Type: Article

References (41)

1. Hohenberger P, Gretschel S,. Gastric cancer. Lancet. 2003; 362: 305-315.
2. Reim D, Gertler R, Novotny A, et al. Adenocarcinomas of the esophagogastric junction are more likely to respond to preoperative chemotherapy than distal gastric cancer. Ann Surg Oncol. 2012; 19: 2108-2118.
3. Kamangar F, Dores GM, Anderson WF,. Patterns of cancer incidence, mortality, and prevalence across 5 continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006; 24: 2137-2150.
4. Devesa SS, Blot WJ, Fraumeni JF,. Jr Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998; 83: 2049-2053.
5. Cronin J, McAdam E, Danikas A, et al. Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and may represent a biomarker of histological progression in Barrett's esophagus (BE). Am J Gastroenterol. 2011; 106: 46-56.
6. Rugge M, Fassan M, Zaninotto G, et al. Aurora kinase A in Barrett's carcinogenesis. Hum Pathol. 2010; 41: 1380-1386.
7. Deng N, Goh LK, Wang H, et al. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut. 2012; 61: 673-684.
8. Sehdev V, Peng D, Soutto M, et al. The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma Cells. Mol Cancer Ther. 2012; 11: 763-774.
9. Lord RV, O'Grady R, Sheehan C, Field AF, Ward RL,. K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junction. J Gastroenterol Hepatol. 2000; 15: 730-736.
10. Matuschek C, Bolke E, Peiper M, et al. The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract. Eur J Med Res. 2011; 16: 265-274.
11. Rygiel AM, Milano F, Ten Kate FJ, et al. Gains and amplifications of c-myc, EGFR, and 20q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2008; 17: 1380-1385.
12. El-Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S, Miettinen M,. DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance. Cancer Res. 2000; 60: 3899-3903.
13. Dar AA, Goff LW, Majid S, Berlin J, El-Rifai W,. Aurora kinase inhibitors-rising stars in cancer therapeutics? Mol Cancer Ther. 2010; 9: 268-278.
14. Berdnik D, Knoblich JA,. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Curr Biol. 2002; 12: 640-647.
15. Hirota T, Kunitoku N, Sasayama T, et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell. 2003; 114: 585-598.
16. Sakakura C, Hagiwara A, Yasuoka R, et al. Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer. 2001; 84: 824-831.
17. Van Cutsem E, Van de Velde C, Roth A, et al. Expert opinion on management of gastric and gastro-oesophageal junction adenocarcinoma on behalf of the European Organisation for Research and Treatment of Cancer (EORTC)- Gastrointestinal Cancer Group. Eur J Cancer. 2008; 44: 182-194.
18. Sumi K, Tago K, Kasahara T, Funakoshi-Tago M,. Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells. FEBS Lett. 2011; 585: 1884-1890.
19. Anand S, Penrhyn-Lowe S, Venkitaraman AR,. Aurora-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell. 2003; 3: 51-62.
20. Alsafadi S, Tourpin S, Andre F, Vassal G, Ahomadegbe JC,. P53 family: at the crossroads in cancer therapy. Curr Med Chem. 2009; 16: 4328-4344.
21. Liu Q, Kaneko S, Yang L, et al. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem. 2004; 279: 52175-52182.
22. Dar AA, Belkhiri A, Ecsedy J, Zaika A, El-Rifai W,. Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells. Cancer Res. 2008; 68: 8998-9004.
23. Gorgun G, Calabrese E, Hideshima T, et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood. 2010; 115: 5202-5213.
24. Hernandez-Vargas H, Palacios J, Moreno-Bueno G,. Telling cells how to die: docetaxel therapy in cancer cell lines. Cell Cycle. 2007; 6: 780-783.
25. Soussi T, Asselain B, Hamroun D, et al. Meta-analysis of the p53 mutation database for mutant p53 biological activity reveals a methodological bias in mutation detection. Clin Cancer Res 2006; 12: 62-69.
26. Boonstra JJ, van Marion R, Beer DG, et al. Verification and unmasking of widely used human esophageal adenocarcinoma cell lines. J Natl Cancer Inst. 2010; 102: 271-274.
27. Soutto M, Belkhiri A, Piazuelo MB, et al. Loss of TFF1 is associated with activation of NF-kappaB-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest. 2011; 121: 1753-1767.
28. Mukherjee K, Peng D, Brifkani Z, et al. Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis. Surgery. 2010; 148: 354-363.
29. Fichter CD, Herz C, Munch C, Opitz OG, Werner M, Lassmann S,. Occurrence of multipolar mitoses and association with aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells [serial online]. BMC Cell Biol. 2011; 12: 13.
30. Dar AA, Zaika A, Piazuelo MB, et al. Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer. 2008; 112: 1688-1698.
31. Wysong DR, Chakravarty A, Hoar K, Ecsedy JA,. The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents. Cell Cycle. 2009; 8: 876-888.
32. Weaver BA, Cleveland DW,. Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death. Cancer Cell. 2005; 8: 7-12.
33. Kubota E, Kataoka H, Tanaka M, et al. ERas enhances resistance to CPT-11 in gastric cancer. Anticancer Res. 2011; 31: 3353-3360.
34. Hildebrandt MA, Yang H, Hung MC, et al. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. J Clin Oncol. 2009; 27: 857-871.
35. Tanaka M, Obata T, Sasaki T,. Evaluation of antitumour effects of docetaxel (Taxotere) on human gastric cancers in vitro and in vivo. Eur J Cancer. 1996; 32A: 226-230.
36. Qi W, Cooke LS, Liu X, et al. Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma. Biochem Pharmacol. 2011; 81: 881-890.
37. Kelly KR, Ecsedy J, Medina E, et al. The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukemia and significantly increases the efficacy of nilotinib. J Cell Mol Med. 2011; 15: 2057-2070.
38. Kretzner L, Scuto A, Dino PM, et al. Combining histone deacetylase inhibitor vorinostat with Aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. Cancer Res. 2011; 71: 3912-3920.
39. Koike M, Fujita F, Komori K, et al. Dependence of chemotherapy response on p53 mutation status in a panel of human cancer lines maintained in nude mice. Cancer Sci. 2004; 95: 541-546.
40. Oki E, Zhao Y, Yoshida R, et al. The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract. Digestion. 2009; 79 (suppl 1): 33-39.
41. Qin L, Tong T, Song Y, Xue L, Fan F, Zhan Q,. Aurora-A interacts with cyclin B1 and enhances its stability. Cancer Lett. 2009; 275: 77-85.