Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition

Journal of Clinical Investigation

Volumn 120, Issue 7, 2010, Pages 2528-2536

  Johnson, Søren M ^a   Torrice, Chad D ^a   Bell, Jessica F ^a   Monahan, Kimberly B ^a   Jiang, Qi ^a   Wang, Yong ^b   Ramsey, Matthew R ^a   Jin, Jian ^c   Wong, Kwok Kin ^d   Su, Lishan ^a   Zhou, Daohong ^b   Sharpless, Norman E ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 12,13 DIHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4]CARBAZOLE 5,6 DIONE; 6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; DOXORUBICIN; FLAVOPIRIDOL; PYRROLE DERIVATIVE; R 547; ROSCOVITINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 2C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD TOXICITY; CANCER RADIOTHERAPY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIVITY; WHOLE BODY RADIATION; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL CYCLE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; HEMATOPOIETIC STEM CELL; METABOLISM; MOUSE MUTANT; RADIATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P18; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; RADIATION;

EID: 77954997865     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI41402     Document Type: Article

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