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Volumn 17, Issue 5, 2016, Pages 280-292

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 6; CYCLIN E; CYCLINE; DNA;

EID: 84962071033     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm.2016.27     Document Type: Review
Times cited : (400)

References (173)
  • 2
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: A changing paradigm
    • Malumbres, M. & Barbacid, M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 9, 153-166 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 3
    • 84908473540 scopus 로고    scopus 로고
    • Cyclin-dependent kinases
    • Malumbres, M. Cyclin-dependent kinases. Genome Biol. 15, 122 (2014).
    • (2014) Genome Biol. , vol.15 , pp. 122
    • Malumbres, M.1
  • 4
    • 84899434901 scopus 로고    scopus 로고
    • Signaling through cyclin D-dependent kinases
    • Choi, Y. J. & Anders, L. Signaling through cyclin D-dependent kinases. Oncogene 33, 1890-1903 (2014).
    • (2014) Oncogene , vol.33 , pp. 1890-1903
    • Choi, Y.J.1    Anders, L.2
  • 5
    • 84876808719 scopus 로고    scopus 로고
    • Molecular mechanisms underlying RB protein function
    • Dick, F. A. & Rubin, S. M. Molecular mechanisms underlying RB protein function. Nat. Rev. Mol. Cell Biol. 14, 297-306 (2013).
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 297-306
    • Dick, F.A.1    Rubin, S.M.2
  • 6
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim, R. et al. The landscape of somatic copy-number alteration across human cancers. Nature 463, 899-905 (2010).
    • (2010) Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1
  • 7
    • 18344372831 scopus 로고    scopus 로고
    • Cyclins and cdks in development and cancer: A perspective
    • Deshpande, A., Sicinski, P. & Hinds, P. W. Cyclins and cdks in development and cancer: a perspective. Oncogene 24, 2909-2915 (2005).
    • (2005) Oncogene , vol.24 , pp. 2909-2915
    • Deshpande, A.1    Sicinski, P.2    Hinds, P.W.3
  • 9
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1, 222-231 (2001).
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 10
  • 11
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura, I. et al. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430, 226-231 (2004).
    • (2004) Nature , vol.430 , pp. 226-231
    • Matsuura, I.1
  • 12
    • 81255205373 scopus 로고    scopus 로고
    • A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
    • Anders, L. et al. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 20, 620-634 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 620-634
    • Anders, L.1
  • 13
    • 77957966270 scopus 로고    scopus 로고
    • Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
    • Aggarwal, P. et al. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell 18, 329-340 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 329-340
    • Aggarwal, P.1
  • 14
    • 33644882481 scopus 로고    scopus 로고
    • Regulation of the transcription factor FOXM1c by cyclin E/CDK2
    • Luscher-Firzlaff, J. M., Lilischkis, R. & Luscher, B. Regulation of the transcription factor FOXM1c by cyclin E/CDK2. FEBS Lett. 580, 1716-1722 (2006).
    • (2006) FEBS Lett. , vol.580 , pp. 1716-1722
    • Luscher-Firzlaff, J.M.1    Lilischkis, R.2    Luscher, B.3
  • 15
    • 0031024647 scopus 로고    scopus 로고
    • Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors
    • Hara, E., Hall, M. & Peters, G. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. EMBO J. 16, 332-342 (1997).
    • (1997) EMBO J. , vol.16 , pp. 332-342
    • Hara, E.1    Hall, M.2    Peters, G.3
  • 16
    • 0033118941 scopus 로고    scopus 로고
    • Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF
    • Voit, R., Hoffmann, M. & Grummt, I. Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. EMBO J. 18, 1891-1899 (1999).
    • (1999) EMBO J. , vol.18 , pp. 1891-1899
    • Voit, R.1    Hoffmann, M.2    Grummt, I.3
  • 17
    • 0141591674 scopus 로고    scopus 로고
    • Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway
    • Yun, J. et al. Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway. J. Biol. Chem. 278, 36966-36972 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 36966-36972
    • Yun, J.1
  • 18
    • 2942614689 scopus 로고    scopus 로고
    • Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions
    • Chae, H. D., Yun, J., Bang, Y. J. & Shin, D. Y. Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions. Oncogene 23, 4084-4088 (2004).
    • (2004) Oncogene , vol.23 , pp. 4084-4088
    • Chae, H.D.1    Yun, J.2    Bang, Y.J.3    Shin, D.Y.4
  • 19
    • 0034665757 scopus 로고    scopus 로고
    • NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    • Zhao, J. et al. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 14, 2283-2297 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2283-2297
    • Zhao, J.1
  • 20
    • 0034665635 scopus 로고    scopus 로고
    • NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription
    • NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14, 2298-2313 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2298-2313
    • Ma, T.1
  • 21
    • 0032569780 scopus 로고    scopus 로고
    • The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties
    • Saville, M. K. & Watson, R. J. The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. Oncogene 17, 2679-2689 (1998).
    • (1998) Oncogene , vol.17 , pp. 2679-2689
    • Saville, M.K.1    Watson, R.J.2
  • 22
    • 76249101395 scopus 로고    scopus 로고
    • Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
    • Hydbring, P. et al. Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation. Proc. Natl Acad. Sci. USA 107, 58-63 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 58-63
    • Hydbring, P.1
  • 23
    • 77949730783 scopus 로고    scopus 로고
    • Cdk2 suppresses cellular senescence induced by the c-myc oncogene
    • Campaner, S. et al. Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat. Cell Biol. 12, 54-59 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 54-59
    • Campaner, S.1
  • 24
    • 0028145332 scopus 로고
    • Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators
    • Rao, S. S., Chu, C. & Kohtz, D. S. Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators. Mol. Cell. Biol. 14, 5259-5267 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5259-5267
    • Rao, S.S.1    Chu, C.2    Kohtz, D.S.3
  • 25
    • 0028928036 scopus 로고
    • Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
    • Skapek, S. X., Rhee, J., Spicer, D. B. & Lassar, A. B. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 267, 1022-1024 (1995).
    • (1995) Science , vol.267 , pp. 1022-1024
    • Skapek, S.X.1    Rhee, J.2    Spicer, D.B.3    Lassar, A.B.4
  • 26
    • 0029985115 scopus 로고    scopus 로고
    • Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation
    • Skapek, S. X., Rhee, J., Kim, P. S., Novitch, B. G. & Lassar, A. B. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Mol. Cell. Biol. 16, 7043-7053 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 7043-7053
    • Skapek, S.X.1    Rhee, J.2    Kim, P.S.3    Novitch, B.G.4    Lassar, A.B.5
  • 27
    • 0033558347 scopus 로고    scopus 로고
    • Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4
    • Zhang, J. M., Wei, Q., Zhao, X. & Paterson, B. M. Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4. EMBO J. 18, 926-933 (1999).
    • (1999) EMBO J. , vol.18 , pp. 926-933
    • Zhang, J.M.1    Wei, Q.2    Zhao, X.3    Paterson, B.M.4
  • 28
    • 0028872607 scopus 로고
    • Differential regulation of E2F and Sp1-mediated transcription by G1 cyclins
    • Shao, Z. & Robbins, P. D. Differential regulation of E2F and Sp1-mediated transcription by G1 cyclins. Oncogene 10, 221-228 (1995).
    • (1995) Oncogene , vol.10 , pp. 221-228
    • Shao, Z.1    Robbins, P.D.2
  • 29
    • 0033531268 scopus 로고    scopus 로고
    • II250 to regulate Sp1-mediated transcription
    • II250 to regulate Sp1-mediated transcription. Oncogene 18, 239-247 (1999).
    • (1999) Oncogene , vol.18 , pp. 239-247
    • Adnane, J.1    Shao, Z.2    Robbins, P.D.3
  • 30
    • 0030968438 scopus 로고    scopus 로고
    • CDK-independent activation of estrogen receptor by cyclin D1
    • Zwijsen, R. M. et al. CDK-independent activation of estrogen receptor by cyclin D1. Cell 88, 405-415 (1997).
    • (1997) Cell , vol.88 , pp. 405-415
    • Zwijsen, R.M.1
  • 31
    • 0030745396 scopus 로고    scopus 로고
    • Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4
    • Neuman, E. et al. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol. Cell. Biol. 17, 5338-5347 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5338-5347
    • Neuman, E.1
  • 32
    • 0033545929 scopus 로고    scopus 로고
    • P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
    • McMahon, C., Suthiphongchai, T., Di Renzo, J. & Ewen, M. E. P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor. Proc. Natl Acad. Sci. USA 96, 5382-5387 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5382-5387
    • McMahon, C.1    Suthiphongchai, T.2    Di Renzo, J.3    Ewen, M.E.4
  • 33
    • 0033563091 scopus 로고    scopus 로고
    • D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability
    • Knudsen, K. E., Cavenee, W. K. & Arden, K. C. D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res. 59, 2297-2301 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 2297-2301
    • Knudsen, K.E.1    Cavenee, W.K.2    Arden, K.C.3
  • 34
    • 0037127320 scopus 로고    scopus 로고
    • Cyclin D1: Mechanism and consequence of androgen receptor co-repressor activity
    • Petre, C. E., Wetherill, Y. B., Danielsen, M. & Knudsen, K. E. Cyclin D1: mechanism and consequence of androgen receptor co-repressor activity. J. Biol. Chem. 277, 2207-2215 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 2207-2215
    • Petre, C.E.1    Wetherill, Y.B.2    Danielsen, M.3    Knudsen, K.E.4
  • 35
    • 0041438474 scopus 로고    scopus 로고
    • Specificity of cyclin D1 for androgen receptor regulation
    • Petre-Draviam, C. E. et al. Specificity of cyclin D1 for androgen receptor regulation. Cancer Res. 63, 4903-4913 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 4903-4913
    • Petre-Draviam, C.E.1
  • 36
    • 17744380196 scopus 로고    scopus 로고
    • Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner
    • Reutens, A. T. et al. Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner. Mol. Endocrinol. 15, 797-811 (2001).
    • (2001) Mol. Endocrinol. , vol.15 , pp. 797-811
    • Reutens, A.T.1
  • 37
    • 23844491848 scopus 로고    scopus 로고
    • Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
    • Fu, M. et al. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J. Biol. Chem. 280, 29728-29742 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 29728-29742
    • Fu, M.1
  • 38
    • 20444439929 scopus 로고    scopus 로고
    • Cyclin D1 inhibits peroxisome proliferator-activated receptor γ-mediated adipogenesis through histone deacetylase recruitment
    • Fu, M. et al. Cyclin D1 inhibits peroxisome proliferator-activated receptor γ-mediated adipogenesis through histone deacetylase recruitment. J. Biol. Chem. 280, 16934-16941 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 16934-16941
    • Fu, M.1
  • 39
    • 0037088594 scopus 로고    scopus 로고
    • Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD
    • Ratineau, C., Petry, M. W., Mutoh, H. & Leiter, A. B. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J. Biol. Chem. 277, 8847-8853 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 8847-8853
    • Ratineau, C.1    Petry, M.W.2    Mutoh, H.3    Leiter, A.B.4
  • 40
    • 77956935652 scopus 로고    scopus 로고
    • Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction
    • Iwatani, K., Fujimoto, T. & Ito, T. Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction. Biochem. Biophys. Res. Commun. 400, 426-431 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.400 , pp. 426-431
    • Iwatani, K.1    Fujimoto, T.2    Ito, T.3
  • 41
    • 0037047269 scopus 로고    scopus 로고
    • Cyclin D1 is a ligand-independent co-repressor for thyroid hormone receptors
    • Lin, H. M., Zhao, L. & Cheng, S. Y. Cyclin D1 is a ligand-independent co-repressor for thyroid hormone receptors. J. Biol. Chem. 277, 28733-28741 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 28733-28741
    • Lin, H.M.1    Zhao, L.2    Cheng, S.Y.3
  • 42
    • 0029851287 scopus 로고    scopus 로고
    • Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1
    • Hirai, H. & Sherr, C. J. Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol. Cell. Biol. 16, 6457-6467 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6457-6467
    • Hirai, H.1    Sherr, C.J.2
  • 43
    • 0031937638 scopus 로고    scopus 로고
    • Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism
    • Inoue, K. & Sherr, C. J. Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Mol. Cell. Biol. 18, 1590-1600 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1590-1600
    • Inoue, K.1    Sherr, C.J.2
  • 44
    • 23944473614 scopus 로고    scopus 로고
    • Cyclin D3 interacts with Vitamin D receptor and regulates its transcription activity
    • Jian, Y. et al. Cyclin D3 interacts with vitamin D receptor and regulates its transcription activity. Biochem. Biophys. Res. Commun. 335, 739-748 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.335 , pp. 739-748
    • Jian, Y.1
  • 45
    • 3843114405 scopus 로고    scopus 로고
    • Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity
    • Liu, W. et al. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. Biochem. Biophys. Res. Commun. 321, 954-960 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.321 , pp. 954-960
    • Liu, W.1
  • 46
    • 27944440404 scopus 로고    scopus 로고
    • The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3
    • Peterson, L. F. et al. The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3. Mol. Cell. Biol. 25, 10205-10219 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10205-10219
    • Peterson, L.F.1
  • 47
    • 0042354669 scopus 로고    scopus 로고
    • A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer
    • Lamb, J. et al. A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 114, 323-334 (2003).
    • (2003) Cell , vol.114 , pp. 323-334
    • Lamb, J.1
  • 48
    • 75149175161 scopus 로고    scopus 로고
    • Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
    • Bienvenu, F. et al. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature 463, 374-378 (2010).
    • (2010) Nature , vol.463 , pp. 374-378
    • Bienvenu, F.1
  • 49
    • 33645553397 scopus 로고    scopus 로고
    • Notch 1 inhibits photoreceptor production in the developing mammalian retina
    • Jadhav, A. P., Mason, H. A. & Cepko, C. L. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development 133, 913-923 (2006).
    • (2006) Development , vol.133 , pp. 913-923
    • Jadhav, A.P.1    Mason, H.A.2    Cepko, C.L.3
  • 50
    • 0029111934 scopus 로고
    • Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    • Sicinski, P. et al. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82, 621-630 (1995).
    • (1995) Cell , vol.82 , pp. 621-630
    • Sicinski, P.1
  • 51
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl, V., Stamp, G., Andrews, A., Rosewell, I. & Dickson, C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 9, 2364-2372 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 52
    • 84863256545 scopus 로고    scopus 로고
    • ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
    • Casimiro, M. C. et al. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J. Clin. Invest. 122, 833-843 (2012).
    • (2012) J. Clin. Invest , vol.122 , pp. 833-843
    • Casimiro, M.C.1
  • 53
    • 34247571525 scopus 로고    scopus 로고
    • Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPα interaction
    • Fujimoto, T., Anderson, K., Jacobsen, S. E., Nishikawa, S. I. & Nerlov, C. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPα interaction. EMBO J. 26, 2361-2370 (2007).
    • (2007) EMBO J. , vol.26 , pp. 2361-2370
    • Fujimoto, T.1    Anderson, K.2    Jacobsen, S.E.3    Nishikawa, S.I.4    Nerlov, C.5
  • 54
    • 84881528286 scopus 로고    scopus 로고
    • A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis
    • Kollmann, K. et al. A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 24, 167-181 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 167-181
    • Kollmann, K.1
  • 55
    • 33748029795 scopus 로고    scopus 로고
    • Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: Implication of tumor vascularization
    • Yasui, M. et al. Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization. Clin. Cancer Res. 12, 4720-4729 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4720-4729
    • Yasui, M.1
  • 56
    • 84920591660 scopus 로고    scopus 로고
    • CDK6 as a key regulator of hematopoietic and leukemic stem cell activation
    • Scheicher, R. et al. CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood 125, 90-101 (2015).
    • (2015) Blood , vol.125 , pp. 90-101
    • Scheicher, R.1
  • 57
    • 7244220162 scopus 로고    scopus 로고
    • DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
    • Ira, G. et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431, 1011-1017 (2004).
    • (2004) Nature , vol.431 , pp. 1011-1017
    • Ira, G.1
  • 58
    • 11244269445 scopus 로고    scopus 로고
    • The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
    • Aylon, Y., Liefshitz, B. & Kupiec, M. The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J. 23, 4868-4875 (2004).
    • (2004) EMBO J. , vol.23 , pp. 4868-4875
    • Aylon, Y.1    Liefshitz, B.2    Kupiec, M.3
  • 59
    • 0037093318 scopus 로고    scopus 로고
    • Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III
    • Caspari, T., Murray, J. M. & Carr, A. M. Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes Dev. 16, 1195-1208 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 1195-1208
    • Caspari, T.1    Murray, J.M.2    Carr, A.M.3
  • 60
    • 53349162987 scopus 로고    scopus 로고
    • CDK targets Sae2 to control DNA-end resection and homologous recombination
    • Huertas, P., Cortes-Ledesma, F., Sartori, A. A., Aguilera, A. & Jackson, S. P. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455, 689-692 (2008).
    • (2008) Nature , vol.455 , pp. 689-692
    • Huertas, P.1    Cortes-Ledesma, F.2    Sartori, A.A.3    Aguilera, A.4    Jackson, S.P.5
  • 61
    • 77649222970 scopus 로고    scopus 로고
    • Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair
    • Saponaro, M. et al. Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair. PLoS Genet. 6, e1000858 (2010).
    • (2010) PLoS Genet , vol.6 , pp. e1000858
    • Saponaro, M.1
  • 62
    • 77957368466 scopus 로고    scopus 로고
    • Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity
    • Granata, M. et al. Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity. PLoS Genet. 6, e1001047 (2010).
    • (2010) PLoS Genet , vol.6 , pp. e1001047
    • Granata, M.1
  • 63
    • 84868034800 scopus 로고    scopus 로고
    • Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation
    • Wang, G., Tong, X., Weng, S. & Zhou, H. Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation. Cell Cycle 11, 3792-3800 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 3792-3800
    • Wang, G.1    Tong, X.2    Weng, S.3    Zhou, H.4
  • 64
    • 84876853162 scopus 로고    scopus 로고
    • Site-specific phosphorylation of the DNA damage response mediator Rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1
    • Abreu, C. M. et al. Site-specific phosphorylation of the DNA damage response mediator Rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1. PLoS Genet. 9, e1003310 (2013).
    • (2013) PLoS Genet , vol.9 , pp. e1003310
    • Abreu, C.M.1
  • 65
    • 80052492286 scopus 로고    scopus 로고
    • Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation
    • Chen, X. et al. Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation. Nat. Struct. Mol. Biol. 18, 1015-1019 (2011).
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 1015-1019
    • Chen, X.1
  • 66
    • 84883509448 scopus 로고    scopus 로고
    • Controlling DNA-end resection: A new task for CDKs
    • Ferretti, L. P., Lafranchi, L. & Sartori, A. A. Controlling DNA-end resection: a new task for CDKs. Front. Genet. 4, 99 (2013).
    • (2013) Front. Genet , vol.4 , pp. 99
    • Ferretti, L.P.1    Lafranchi, L.2    Sartori, A.A.3
  • 67
    • 15844373362 scopus 로고    scopus 로고
    • CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
    • Esashi, F. et al. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434, 598-604 (2005).
    • (2005) Nature , vol.434 , pp. 598-604
    • Esashi, F.1
  • 68
    • 67649881097 scopus 로고    scopus 로고
    • The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry
    • Ayoub, N. et al. The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry. Curr. Biol. 19, 1075-1085 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 1075-1085
    • Ayoub, N.1
  • 69
    • 0032566753 scopus 로고    scopus 로고
    • The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
    • Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A. & Baer, R. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J. Biol. Chem. 273, 25388-25392 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 25388-25392
    • Yu, X.1    Wu, L.C.2    Bowcock, A.M.3    Aronheim, A.4    Baer, R.5
  • 70
    • 0034616913 scopus 로고    scopus 로고
    • Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
    • Agami, R. & Bernards, R. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 102, 55-66 (2000).
    • (2000) Cell , vol.102 , pp. 55-66
    • Agami, R.1    Bernards, R.2
  • 71
    • 36248975284 scopus 로고    scopus 로고
    • Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
    • Aggarwal, P. et al. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev. 21, 2908-2922 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 2908-2922
    • Aggarwal, P.1
  • 72
    • 78449273892 scopus 로고    scopus 로고
    • Alternative cyclin D1 splice forms differentially regulate the DNA damage response
    • Li, Z. et al. Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res. 70, 8802-8811 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 8802-8811
    • Li, Z.1
  • 73
    • 79958254560 scopus 로고    scopus 로고
    • A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
    • Jirawatnotai, S. et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474, 230-234 (2011).
    • (2011) Nature , vol.474 , pp. 230-234
    • Jirawatnotai, S.1
  • 74
    • 0001443049 scopus 로고    scopus 로고
    • Cyclin D1 overexpression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line
    • Coco Martin, J. M., Balkenende, A., Verschoor, T., Lallemand, F. & Michalides, R. Cyclin D1 overexpression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line. Cancer Res. 59, 1134-1140 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 1134-1140
    • Coco Martin, J.M.1    Balkenende, A.2    Verschoor, T.3    Lallemand, F.4    Michalides, R.5
  • 75
    • 0035919215 scopus 로고    scopus 로고
    • Cyclin D1 overexpression associates with radiosensitivity in oral squamous cell carcinoma
    • Shintani, S., Mihara, M., Ueyama, Y., Matsumura, T. & Wong, D. T. Cyclin D1 overexpression associates with radiosensitivity in oral squamous cell carcinoma. Int. J. Cancer 96, 159-165 (2001).
    • (2001) Int. J. Cancer , vol.96 , pp. 159-165
    • Shintani, S.1    Mihara, M.2    Ueyama, Y.3    Matsumura, T.4    Wong, D.T.5
  • 76
    • 84938632165 scopus 로고    scopus 로고
    • RB1 dual role in proliferation and apoptosis: Cell fate control and implications for cancer therapy
    • Indovina, P., Pentimalli, F., Casini, N., Vocca, I. & Giordano, A. RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy. Oncotarget 6, 17873-17890 (2015).
    • (2015) Oncotarget , vol.6 , pp. 17873-17890
    • Indovina, P.1    Pentimalli, F.2    Casini, N.3    Vocca, I.4    Giordano, A.5
  • 77
    • 0030031514 scopus 로고    scopus 로고
    • Cyclin D1 is an essential mediator of apoptotic neuronal cell death
    • Kranenburg, O., van der Eb, A. J. & Zantema, A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15, 46-54 (1996).
    • (1996) EMBO J. , vol.15 , pp. 46-54
    • Kranenburg, O.1    Van-Der-Eb, A.J.2    Zantema, A.3
  • 78
    • 0035138069 scopus 로고    scopus 로고
    • Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line
    • Duquesne, F., Florent, M., Roue, G., Troussard, X. & Sola, B. Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line. Cell Death Differ. 8, 51-62 (2001).
    • (2001) Cell Death Differ. , vol.8 , pp. 51-62
    • Duquesne, F.1    Florent, M.2    Roue, G.3    Troussard, X.4    Sola, B.5
  • 79
    • 50049115917 scopus 로고    scopus 로고
    • Cyclin D1 mediates resistance to apoptosis through upregulation of molecular chaperones and consequent redistribution of cell death regulators
    • Roue, G., Pichereau, V., Lincet, H., Colomer, D. & Sola, B. Cyclin D1 mediates resistance to apoptosis through upregulation of molecular chaperones and consequent redistribution of cell death regulators. Oncogene 27, 4909-4920 (2008).
    • (2008) Oncogene , vol.27 , pp. 4909-4920
    • Roue, G.1    Pichereau, V.2    Lincet, H.3    Colomer, D.4    Sola, B.5
  • 80
    • 10244227982 scopus 로고    scopus 로고
    • kip1, inhibits growth, and enhances apoptosis
    • kip1, inhibits growth, and enhances apoptosis. Cell Growth Differ. 7, 699-710 (1996).
    • (1996) Cell Growth Differ. , vol.7 , pp. 699-710
    • Han, E.K.1
  • 81
    • 0035859008 scopus 로고    scopus 로고
    • Ectopic expression of cyclin D1 amplifies a retinoic acid-induced mitochondrial death pathway in breast cancer cells
    • Niu, M. Y., Menard, M., Reed, J. C., Krajewski, S. & Pratt, M. A. Ectopic expression of cyclin D1 amplifies a retinoic acid-induced mitochondrial death pathway in breast cancer cells. Oncogene 20, 3506-3518 (2001).
    • (2001) Oncogene , vol.20 , pp. 3506-3518
    • Niu, M.Y.1    Menard, M.2    Reed, J.C.3    Krajewski, S.4    Pratt, M.A.5
  • 82
    • 0029778442 scopus 로고    scopus 로고
    • Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line
    • Hochhauser, D. et al. Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. J. Natl Cancer Inst. 88, 1269-1275 (1996).
    • (1996) J. Natl Cancer Inst. , vol.88 , pp. 1269-1275
    • Hochhauser, D.1
  • 83
    • 0033565625 scopus 로고    scopus 로고
    • Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes
    • Kornmann, M. et al. Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res. 59, 3505-3511 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 3505-3511
    • Kornmann, M.1
  • 84
    • 0033520926 scopus 로고    scopus 로고
    • Cyclin D3 regulates proliferation and apoptosis of leukemic T cell lines
    • Boonen, G. J. et al. Cyclin D3 regulates proliferation and apoptosis of leukemic T cell lines. J. Biol. Chem. 274, 34676-34682 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 34676-34682
    • Boonen, G.J.1
  • 85
    • 84867618851 scopus 로고    scopus 로고
    • The requirement for cyclin D function in tumor maintenance
    • Choi, Y. J. et al. The requirement for cyclin D function in tumor maintenance. Cancer Cell 22, 438-451 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 438-451
    • Choi, Y.J.1
  • 86
    • 79961079532 scopus 로고    scopus 로고
    • A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma
    • Beltran, E. et al. A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma. Proc. Natl Acad. Sci. USA 108, 12461-12466 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 12461-12466
    • Beltran, E.1
  • 87
    • 0034594915 scopus 로고    scopus 로고
    • Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death
    • Suzuki, A. et al. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene 19, 1346-1353 (2000).
    • (2000) Oncogene , vol.19 , pp. 1346-1353
    • Suzuki, A.1
  • 88
    • 0037076326 scopus 로고    scopus 로고
    • Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death
    • Mendelsohn, A. R., Hamer, J. D., Wang, Z. B. & Brent, R. Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death. Proc. Natl Acad. Sci. USA 99, 6871-6876 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 6871-6876
    • Mendelsohn, A.R.1    Hamer, J.D.2    Wang, Z.B.3    Brent, R.4
  • 89
    • 0034730122 scopus 로고    scopus 로고
    • Cyclin-dependent kinases as a therapeutic target for stroke
    • Osuga, H. et al. Cyclin-dependent kinases as a therapeutic target for stroke. Proc. Natl Acad. Sci. USA 97, 10254-10259 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10254-10259
    • Osuga, H.1
  • 90
    • 0035882278 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo
    • Osuino, H. & Chiba, T. Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo. J. Neurosci. 21, 6086-6094 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 6086-6094
    • Osuino, H.1    Chiba, T.2
  • 91
    • 0032544003 scopus 로고    scopus 로고
    • A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice
    • Ma, C., Papermaster, D. & Cepko, C. L. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc. Natl Acad. Sci. USA 95, 9938-9943 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 9938-9943
    • Ma, C.1    Papermaster, D.2    Cepko, C.L.3
  • 92
    • 84905719128 scopus 로고    scopus 로고
    • D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL
    • Choi, Y. J. et al. D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. Dev. Cell 30, 255-267 (2014).
    • (2014) Dev. Cell , vol.30 , pp. 255-267
    • Choi, Y.J.1
  • 93
    • 33750032892 scopus 로고    scopus 로고
    • CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
    • Huang, H., Regan, K. M., Lou, Z., Chen, J. & Tindall, D. J. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314, 294-297 (2006).
    • (2006) Science , vol.314 , pp. 294-297
    • Huang, H.1    Regan, K.M.2    Lou, Z.3    Chen, J.4    Tindall, D.J.5
  • 94
    • 84938242052 scopus 로고    scopus 로고
    • Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
    • Choudhary, G. S. et al. Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics. Oncotarget 6, 16912-16925 (2015).
    • (2015) Oncotarget , vol.6 , pp. 16912-16925
    • Choudhary, G.S.1
  • 95
    • 84871234707 scopus 로고    scopus 로고
    • Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium
    • Brown, N. E. et al. Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium. Cancer Res. 72, 6477-6489 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 6477-6489
    • Brown, N.E.1
  • 96
    • 78049262912 scopus 로고    scopus 로고
    • The RB-E2F1 pathway regulates autophagy
    • Jiang, H. et al. The RB-E2F1 pathway regulates autophagy. Cancer Res. 70, 7882-7893 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 7882-7893
    • Jiang, H.1
  • 97
    • 70349185119 scopus 로고    scopus 로고
    • Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis
    • Gan, L. et al. Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis. Cell Death Differ. 16, 1408-1417 (2009).
    • (2009) Cell Death Differ. , vol.16 , pp. 1408-1417
    • Gan, L.1
  • 98
    • 33745184891 scopus 로고    scopus 로고
    • Cyclin D1-Cdk4 induce Runx2 ubiquitination and degradation
    • Shen, R. et al. Cyclin D1-Cdk4 induce Runx2 ubiquitination and degradation. J. Biol. Chem. 281, 16347-16353 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 16347-16353
    • Shen, R.1
  • 99
    • 78149285100 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
    • Chen, S. et al. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat. Cell Biol. 12, 1108-1114 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 1108-1114
    • Chen, S.1
  • 100
    • 78649807567 scopus 로고    scopus 로고
    • Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    • Kaneko, S. et al. Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev. 24, 2615-2620 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2615-2620
    • Kaneko, S.1
  • 101
    • 0028926433 scopus 로고
    • Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor. A role for cyclin D1 in control of myoblast differentiation
    • Rao, S. S. & Kohtz, D. S. Positive and negative regulation of D-type cyclin expression in skeletal myoblasts by basic fibroblast growth factor and transforming growth factor. A role for cyclin D1 in control of myoblast differentiation. J. Biol. Chem. 270, 4093-4100 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 4093-4100
    • Rao, S.S.1    Kohtz, D.S.2
  • 102
    • 0037099488 scopus 로고    scopus 로고
    • Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation
    • Lazaro, J. B., Bailey, P. J. & Lassar, A. B. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 16, 1792-1805 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 1792-1805
    • Lazaro, J.B.1    Bailey, P.J.2    Lassar, A.B.3
  • 103
    • 79955379525 scopus 로고    scopus 로고
    • Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway
    • Nakajima, K. et al. Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Development 138, 1771-1782 (2011).
    • (2011) Development , vol.138 , pp. 1771-1782
    • Nakajima, K.1
  • 104
    • 0028869492 scopus 로고
    • Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubes
    • Kiess, M., Gill, R. M. & Hamel, P. A. Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubes. Oncogene 10, 159-166 (1995).
    • (1995) Oncogene , vol.10 , pp. 159-166
    • Kiess, M.1    Gill, R.M.2    Hamel, P.A.3
  • 105
    • 0033066683 scopus 로고    scopus 로고
    • Critical role played by cyclin D3 in the MyoD-mediated arrest of cell cycle during myoblast differentiation
    • Cenciarelli, C. et al. Critical role played by cyclin D3 in the MyoD-mediated arrest of cell cycle during myoblast differentiation. Mol. Cell. Biol. 19, 5203-5217 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5203-5217
    • Cenciarelli, C.1
  • 106
    • 35148894393 scopus 로고    scopus 로고
    • PRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation
    • De Santa, F. et al. pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation. Mol. Cell. Biol. 27, 7248-7265 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 7248-7265
    • De Santa, F.1
  • 107
    • 0032572761 scopus 로고    scopus 로고
    • Cyclin D3: Requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation
    • Bartkova, J., Lukas, J., Strauss, M. & Bartek, J. Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation. Oncogene 17, 1027-1037 (1998).
    • (1998) Oncogene , vol.17 , pp. 1027-1037
    • Bartkova, J.1    Lukas, J.2    Strauss, M.3    Bartek, J.4
  • 108
    • 0031865910 scopus 로고    scopus 로고
    • Cyclin D3 expression in normal, reactive and neoplastic tissues
    • Doglioni, C. et al. Cyclin D3 expression in normal, reactive and neoplastic tissues. J. Pathol. 185, 159-166 (1998).
    • (1998) J. Pathol. , vol.185 , pp. 159-166
    • Doglioni, C.1
  • 109
    • 27644594719 scopus 로고    scopus 로고
    • Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor γ
    • Sarruf, D. A. et al. Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor γ. Mol. Cell. Biol. 25, 9985-9995 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 9985-9995
    • Sarruf, D.A.1
  • 110
    • 84906311291 scopus 로고    scopus 로고
    • Cyclin D3 promotes pancreatic β-cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes
    • Saavedra-Avila, N. A. et al. Cyclin D3 promotes pancreatic β-cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes. Proc. Natl Acad. Sci. USA 111, E3405-E3414 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E3405-E3414
    • Saavedra-Avila, N.A.1
  • 111
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451-461 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1
  • 112
    • 84903217316 scopus 로고    scopus 로고
    • Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family
    • Ajioka, I. Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family. Dev. Growth Differ. 56, 324-334 (2014).
    • (2014) Dev. Growth Differ. , vol.56 , pp. 324-334
    • Ajioka, I.1
  • 113
    • 80052444771 scopus 로고    scopus 로고
    • Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis
    • Ali, F. et al. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development 138, 4267-4277 (2011).
    • (2011) Development , vol.138 , pp. 4267-4277
    • Ali, F.1
  • 114
    • 84859882919 scopus 로고    scopus 로고
    • Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation
    • Hindley, C. et al. Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation. Development 139, 1718-1723 (2012).
    • (2012) Development , vol.139 , pp. 1718-1723
    • Hindley, C.1
  • 115
    • 69249213590 scopus 로고    scopus 로고
    • Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors
    • Lange, C., Huttner, W. B. & Calegari, F. Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors. Cell Stem Cell 5, 320-331 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 320-331
    • Lange, C.1    Huttner, W.B.2    Calegari, F.3
  • 116
    • 84862836329 scopus 로고    scopus 로고
    • Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells
    • Lim, S. & Kaldis, P. Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells. Stem Cells 30, 1509-1520 (2012).
    • (2012) Stem Cells , vol.30 , pp. 1509-1520
    • Lim, S.1    Kaldis, P.2
  • 117
    • 0027269615 scopus 로고
    • Identification of cells expressing a D type G1 cyclin in matured brain: Implication for its role in neuronal function
    • Tamaru, T., Trigun, S. K., Okada, M. & Nakagawa, H. Identification of cells expressing a D type G1 cyclin in matured brain: implication for its role in neuronal function. Neurosci. Lett. 153, 169-172 (1993).
    • (1993) Neurosci. Lett. , vol.153 , pp. 169-172
    • Tamaru, T.1    Trigun, S.K.2    Okada, M.3    Nakagawa, H.4
  • 118
    • 0028329062 scopus 로고
    • Differential expression of D type cyclins during neuronal maturation
    • Tamaru, T., Okada, M. & Nakagawa, H. Differential expression of D type cyclins during neuronal maturation. Neurosci. Lett. 168, 229-232 (1994).
    • (1994) Neurosci. Lett. , vol.168 , pp. 229-232
    • Tamaru, T.1    Okada, M.2    Nakagawa, H.3
  • 119
    • 0030034189 scopus 로고    scopus 로고
    • MN20, a D2 cyclin, is transiently expressed in selected neural populations during embryogenesis
    • Ross, M. E., Carter, M. L. & Lee, J. H. MN20, a D2 cyclin, is transiently expressed in selected neural populations during embryogenesis. J. Neurosci. 16, 210-219 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 210-219
    • Ross, M.E.1    Carter, M.L.2    Lee, J.H.3
  • 120
    • 79960977943 scopus 로고    scopus 로고
    • Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner
    • Lukaszewicz, A. I. & Anderson, D. J. Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner. Proc. Natl Acad. Sci. USA 108, 11632-11637 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 11632-11637
    • Lukaszewicz, A.I.1    Anderson, D.J.2
  • 121
    • 79960088065 scopus 로고    scopus 로고
    • Physiological relevance of cell cycle kinases
    • Malumbres, M. Physiological relevance of cell cycle kinases. Physiol. Rev. 91, 973-1007 (2011).
    • (2011) Physiol. Rev. , vol.91 , pp. 973-1007
    • Malumbres, M.1
  • 122
    • 12344267760 scopus 로고    scopus 로고
    • A critical role for cyclin e in cell fate determination in the central nervous system of Drosophila melanogaster
    • Berger, C., Pallavi, S. K., Prasad, M., Shashidhara, L. S. & Technau, G. M. A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7, 56-62 (2005).
    • (2005) Nat. Cell Biol. , vol.7 , pp. 56-62
    • Berger, C.1    Pallavi, S.K.2    Prasad, M.3    Shashidhara, L.S.4    Technau, G.M.5
  • 123
    • 72649095555 scopus 로고    scopus 로고
    • Cell cycle independent role of Cyclin e during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function
    • Berger, C. et al. Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Dev. Biol. 337, 415-424 (2010).
    • (2010) Dev. Biol. , vol.337 , pp. 415-424
    • Berger, C.1
  • 124
    • 80054727556 scopus 로고    scopus 로고
    • Cyclin e constrains Cdk5 activity to regulate synaptic plasticity and memory formation
    • Odajima, J. et al. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev. Cell 21, 655-668 (2011).
    • (2011) Dev. Cell , vol.21 , pp. 655-668
    • Odajima, J.1
  • 125
    • 80054045373 scopus 로고    scopus 로고
    • Cyclin-dependent kinases in brain development and disease
    • Su, S. C. & Tsai, L. H. Cyclin-dependent kinases in brain development and disease. Annu. Rev. Cell Dev. Biol. 27, 465-491 (2011).
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 465-491
    • Su, S.C.1    Tsai, L.H.2
  • 126
    • 84871150208 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 2 controls peripheral immune tolerance
    • Chunder, N., Wang, L., Chen, C., Hancock, W. W. & Wells, A. D. Cyclin-dependent kinase 2 controls peripheral immune tolerance. J. Immunol. 189, 5659-5666 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 5659-5666
    • Chunder, N.1    Wang, L.2    Chen, C.3    Hancock, W.W.4    Wells, A.D.5
  • 127
    • 84897110349 scopus 로고    scopus 로고
    • New roles for cyclin-dependent kinases in T cell biology: Linking cell division and differentiation
    • Wells, A. D. & Morawski, P. A. New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation. Nat. Rev. Immunol. 14, 261-270 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 261-270
    • Wells, A.D.1    Morawski, P.A.2
  • 128
    • 84883164348 scopus 로고    scopus 로고
    • Foxp3 protein stability is regulated by cyclin-dependent kinase 2
    • Morawski, P. A., Mehra, P., Chen, C., Bhatti, T. & Wells, A. D. Foxp3 protein stability is regulated by cyclin-dependent kinase 2. J. Biol. Chem. 288, 24494-24502 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 24494-24502
    • Morawski, P.A.1    Mehra, P.2    Chen, C.3    Bhatti, T.4    Wells, A.D.5
  • 129
    • 0033427205 scopus 로고    scopus 로고
    • Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair
    • Lee, J. & Desiderio, S. Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair. Immunity 11, 771-781 (1999).
    • (1999) Immunity , vol.11 , pp. 771-781
    • Lee, J.1    Desiderio, S.2
  • 130
    • 1542289024 scopus 로고    scopus 로고
    • Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins
    • Jiang, H., Ross, A. E. & Desiderio, S. Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins. J. Biol. Chem. 279, 8478-8486 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 8478-8486
    • Jiang, H.1    Ross, A.E.2    Desiderio, S.3
  • 131
    • 84881524827 scopus 로고    scopus 로고
    • Cyclin D1 localizes in the cytoplasm of keratinocytes during skin differentiation and regulates cell-matrix adhesion
    • Fernandez-Hernandez, R. et al. Cyclin D1 localizes in the cytoplasm of keratinocytes during skin differentiation and regulates cell-matrix adhesion. Cell Cycle 12, 2510-2517 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 2510-2517
    • Fernandez-Hernandez, R.1
  • 132
    • 84943739158 scopus 로고    scopus 로고
    • Cell cycle, cytoskeleton dynamics and beyond: The many functions of cyclins and CDK inhibitors
    • Bendris, N., Lemmers, B. & Blanchard, J. M. Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors. Cell Cycle 14, 1786-1798 (2015).
    • (2015) Cell Cycle , vol.14 , pp. 1786-1798
    • Bendris, N.1    Lemmers, B.2    Blanchard, J.M.3
  • 134
    • 33646893508 scopus 로고    scopus 로고
    • Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
    • Li, Z. et al. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol. Cell. Biol. 26, 4240-4256 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 4240-4256
    • Li, Z.1
  • 135
    • 33750537272 scopus 로고    scopus 로고
    • KIP1
    • KIP1. Cancer Res. 66, 9986-9994 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 9986-9994
    • Li, Z.1
  • 136
    • 43749108882 scopus 로고    scopus 로고
    • KIP1 binding and cell migration
    • KIP1 binding and cell migration. J. Biol. Chem. 283, 7007-7015 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 7007-7015
    • Li, Z.1
  • 137
    • 77950221878 scopus 로고    scopus 로고
    • Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells
    • Zhong, Z. et al. Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res. 70, 2105-2114 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2105-2114
    • Zhong, Z.1
  • 138
    • 84889256981 scopus 로고    scopus 로고
    • Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer
    • Yu, Z. et al. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat. Commun. 4, 2812 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2812
    • Yu, Z.1
  • 139
    • 84909619139 scopus 로고    scopus 로고
    • Cell cycle regulation of mitochondrial function
    • Lopez-Mejia, I. C. & Fajas, L. Cell cycle regulation of mitochondrial function. Curr. Opin. Cell Biol. 33, 19-25 (2015).
    • (2015) Curr. Opin. Cell Biol. , vol.33 , pp. 19-25
    • Lopez-Mejia, I.C.1    Fajas, L.2
  • 140
    • 33745858709 scopus 로고    scopus 로고
    • Cyclin D1 determines mitochondrial function in vivo
    • Sakamaki, T. et al. Cyclin D1 determines mitochondrial function in vivo. Mol. Cell. Biol. 26, 5449-5469 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 5449-5469
    • Sakamaki, T.1
  • 141
    • 33746814985 scopus 로고    scopus 로고
    • Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
    • Wang, C. et al. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc. Natl Acad. Sci. USA 103, 11567-11572 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 11567-11572
    • Wang, C.1
  • 142
    • 79952233335 scopus 로고    scopus 로고
    • Cyclin D1 inhibits mitochondrial activity in B cells
    • Tchakarska, G., Roussel, M., Troussard, X. & Sola, B. Cyclin D1 inhibits mitochondrial activity in B cells. Cancer Res. 71, 1690-1699 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1690-1699
    • Tchakarska, G.1    Roussel, M.2    Troussard, X.3    Sola, B.4
  • 143
    • 84943738406 scopus 로고    scopus 로고
    • Two-way communication between the metabolic and cell cycle machineries: The molecular basis
    • Kaplon, J., van Dam, L. & Peeper, D. Two-way communication between the metabolic and cell cycle machineries: the molecular basis. Cell Cycle 14, 2022-2032 (2015).
    • (2015) Cell Cycle , vol.14 , pp. 2022-2032
    • Kaplon, J.1    Van Dam, L.2    Peeper, D.3
  • 144
    • 84902511908 scopus 로고    scopus 로고
    • Fbw7-dependent cyclin e regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism
    • Xu, Y., Swartz, K. L., Siu, K. T., Bhattacharyya, M. & Minella, A. C. Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene 33, 3161-3171 (2014).
    • (2014) Oncogene , vol.33 , pp. 3161-3171
    • Xu, Y.1    Swartz, K.L.2    Siu, K.T.3    Bhattacharyya, M.4    Minella, A.C.5
  • 145
    • 84899638028 scopus 로고    scopus 로고
    • Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression
    • Wang, Z. et al. Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev. Cell 29, 217-232 (2014).
    • (2014) Dev. Cell , vol.29 , pp. 217-232
    • Wang, Z.1
  • 146
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
    • Rane, S. G. et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia. Nat. Genet. 22, 44-52 (1999).
    • (1999) Nat. Genet , vol.22 , pp. 44-52
    • Rane, S.G.1
  • 147
  • 148
    • 9644266753 scopus 로고    scopus 로고
    • β Cell replication is the primary mechanism for maintaining postnatal β cell mass
    • Georgia, S. & Bhushan, A. β cell replication is the primary mechanism for maintaining postnatal β cell mass. J. Clin. Invest. 114, 963-968 (2004).
    • (2004) J. Clin. Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 149
    • 17644387563 scopus 로고    scopus 로고
    • Cyclins D2 and D1 are essential for postnatal pancreatic β-cell growth
    • Kushner, J. A. et al. Cyclins D2 and D1 are essential for postnatal pancreatic β-cell growth. Mol. Cell. Biol. 25, 3752-3762 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 3752-3762
    • Kushner, J.A.1
  • 150
    • 68249090581 scopus 로고    scopus 로고
    • The CDK4-pRB-E2F1 pathway controls insulin secretion
    • Annicotte, J. S. et al. The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat. Cell Biol. 11, 1017-1023 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1017-1023
    • Annicotte, J.S.1
  • 151
    • 84903521363 scopus 로고    scopus 로고
    • Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression
    • Lee, Y. et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510, 547-551 (2014).
    • (2014) Nature , vol.510 , pp. 547-551
    • Lee, Y.1
  • 152
    • 84864386776 scopus 로고    scopus 로고
    • Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α
    • Hanse, E. A. et al. Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α. Cell Cycle 11, 2681-2690 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 2681-2690
    • Hanse, E.A.1
  • 154
    • 32644473992 scopus 로고    scopus 로고
    • Cdk4 promotes adipogenesis through PPARγ activation
    • Abella, A. et al. Cdk4 promotes adipogenesis through PPARγ activation. Cell Metab. 2, 239-249 (2005).
    • (2005) Cell Metab. , vol.2 , pp. 239-249
    • Abella, A.1
  • 155
    • 77956975444 scopus 로고    scopus 로고
    • Cycling through metabolism
    • Aguilar, V. & Fajas, L. Cycling through metabolism. EMBO Mol. Med. 2, 338-348 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , pp. 338-348
    • Aguilar, V.1    Fajas, L.2
  • 156
    • 84944893518 scopus 로고    scopus 로고
    • Palbociclib in hormone-receptor-positive advanced breast cancer
    • Turner, N. C., Huang Bartlett, C. & Cristofanilli, M. Palbociclib in hormone-receptor-positive advanced breast cancer. N. Engl. J. Med. 373, 1672-1673 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 1672-1673
    • Turner, N.C.1    Huang Bartlett, C.2    Cristofanilli, M.3
  • 157
    • 84959852003 scopus 로고    scopus 로고
    • The history and future of targeting cyclin-dependent kinases in cancer therapy
    • Asghar, U., Witkiewicz, A. K., Turner, N. C. & Knudsen, E. S. The history and future of targeting cyclin-dependent kinases in cancer therapy. Nat. Rev. Drug Discov. 14, 130-146 (2015).
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 130-146
    • Asghar, U.1    Witkiewicz, A.K.2    Turner, N.C.3    Knudsen, E.S.4
  • 158
    • 76049104235 scopus 로고    scopus 로고
    • PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
    • Finn, R. S. et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 11, R77 (2009).
    • (2009) Breast Cancer Res. , vol.11 , pp. R77
    • Finn, R.S.1
  • 159
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr, C. J. & Roberts, J. M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 160
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • Gil, J. & Peters, G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat. Rev. Mol. Cell Biol. 7, 667-677 (2006).
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 161
    • 38849187293 scopus 로고    scopus 로고
    • CDK inhibitors: Cell cycle regulators and beyond
    • Besson, A., Dowdy, S. F. & Roberts, J. M. CDK inhibitors: cell cycle regulators and beyond. Dev. Cell 14, 159-169 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 159-169
    • Besson, A.1    Dowdy, S.F.2    Roberts, J.M.3
  • 162
    • 77953626325 scopus 로고    scopus 로고
    • Cell cycle proteins in epithelial cell differentiation: Implications for breast cancer
    • Caldon, C. E., Sutherland, R. L. & Musgrove, E. Cell cycle proteins in epithelial cell differentiation: implications for breast cancer. Cell Cycle 9, 1918-1928 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 1918-1928
    • Caldon, C.E.1    Sutherland, R.L.2    Musgrove, E.3
  • 163
    • 34248230157 scopus 로고    scopus 로고
    • Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis
    • Myatt, S. S. & Lam, E. W. Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis. Cell Div. 2, 6 (2007).
    • (2007) Cell Div. , vol.2 , pp. 6
    • Myatt, S.S.1    Lam, E.W.2
  • 164
    • 84862316953 scopus 로고    scopus 로고
    • Cycling or not cycling: Cell cycle regulatory molecules and adult neurogenesis
    • Beukelaers, P. et al. Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis. Cell. Mol. Life Sci. 69, 1493-1503 (2012).
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 1493-1503
    • Beukelaers, P.1
  • 165
    • 0037304898 scopus 로고    scopus 로고
    • New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment?
    • Coqueret, O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol. 13, 65-70 (2003).
    • (2003) Trends Cell Biol. , vol.13 , pp. 65-70
    • Coqueret, O.1
  • 166
    • 21244454008 scopus 로고    scopus 로고
    • Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells
    • Ceruti, J. M., Scassa, M. E., Flo, J. M., Varone, C. L. & Canepa, E. T. Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 24, 4065-4080 (2005).
    • (2005) Oncogene , vol.24 , pp. 4065-4080
    • Ceruti, J.M.1    Scassa, M.E.2    Flo, J.M.3    Varone, C.L.4    Canepa, E.T.5
  • 167
    • 84876092425 scopus 로고    scopus 로고
    • Chromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA
    • Ogara, M. F. et al. Chromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA. PLoS ONE 8, e61143 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e61143
    • Ogara, M.F.1
  • 168
    • 1942434712 scopus 로고    scopus 로고
    • Cip/Kip proteins: More than just CDKs inhibitors
    • Denicourt, C. & Dowdy, S. F. Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev. 18, 851-855 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 851-855
    • Denicourt, C.1    Dowdy, S.F.2
  • 169
    • 0031759170 scopus 로고    scopus 로고
    • Kip1 induces cell migration
    • Kip1 induces cell migration. Nat. Med. 4, 1449-1452 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 1449-1452
    • Nagahara, H.1
  • 172
    • 84904490447 scopus 로고    scopus 로고
    • Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiation
    • Liu, Q. et al. Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiation. Mol. Cell. Biol. 34, 3168-3179 (2014).
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 3168-3179
    • Liu, Q.1
  • 173
    • 0035907245 scopus 로고    scopus 로고
    • Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism
    • Bienvenu, F., Gascan, H. & Coqueret, O. Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism. J. Biol. Chem. 276, 16840-16847 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 16840-16847
    • Bienvenu, F.1    Gascan, H.2    Coqueret, O.3


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