MEN1 tumorigenesis in the pituitary and pancreatic islet requires CDK4 but not Cdk2

Oncogene

Volumn 34, Issue 7, 2015, Pages 932-938

  Gillam, M P ^a   Nimbalkar, D ^a   Sun, L ^a   Christov, K ^b   Ray, D ^c   Kaldis, P ^d,e   Liu, X ^a   Kiyokawa, H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cell cycle; Insulinoma; Knockout mice; Menin; Pituitary

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; RETINOBLASTOMA PROTEIN; CDK2 PROTEIN, MOUSE; CDK2 PROTEIN, RAT; CDK4 PROTEIN, MOUSE; CDK4 PROTEIN, RAT; MEN1 PROTEIN, MOUSE; MENIN PROTEIN, RAT; ONCOPROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE INTERACTION; GENE MUTATION; HETEROZYGOSITY LOSS; HYPOPHYSIS TUMOR; MALE; MOUSE; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; NONHUMAN; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WILD TYPE; ANIMAL; CELL TRANSFORMATION; GENETICS; HUMAN; INSULINOMA; KNOCKOUT MOUSE; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PHOSPHORYLATION; RAT;

MAMMALIA; MUS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; FEMALE; HUMANS; INSULINOMA; MALE; MICE; MICE, KNOCKOUT; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PITUITARY NEOPLASMS; PROTO-ONCOGENE PROTEINS; RATS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS;

EID: 84938489166     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.3     Document Type: Article

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