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Volumn 95, Issue 4, 2017, Pages 973-991

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease

Author keywords

aging; Alzheimer's disease; APP; A ; biomarker; cognitive impairment; memory; neurogenesis; neuroprotection; receptor; sAPP ; synaptic plasticity; Tau; therapeutics

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; BETA SECRETASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; SCAVENGER RECEPTOR A; SORTING PROTEIN RELATED RECEPTOR A; UNCLASSIFIED DRUG;

EID: 84997282811     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23823     Document Type: Review
Times cited : (75)

References (178)
  • 1
    • 0030974261 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation
    • Almkvist O, Basun H, Wagner SL, Rowe BA, Wahlund LO, Lannfelt L. 1997. Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. Arch Neurol 54:641–644.
    • (1997) Arch Neurol , vol.54 , pp. 641-644
    • Almkvist, O.1    Basun, H.2    Wagner, S.L.3    Rowe, B.A.4    Wahlund, L.O.5    Lannfelt, L.6
  • 3
    • 0032768748 scopus 로고    scopus 로고
    • Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits
    • Anderson J, Holtz G, Baskin P, Wang R, Mazzarelli L, Wagner S, Menzaghi F. 1999. Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits. Neuroscience 93:1409–1420.
    • (1999) Neuroscience , vol.93 , pp. 1409-1420
    • Anderson, J.1    Holtz, G.2    Baskin, P.3    Wang, R.4    Mazzarelli, L.5    Wagner, S.6    Menzaghi, F.7
  • 6
    • 84861721553 scopus 로고    scopus 로고
    • Functions of the APP gene family in the nervous system: insights from mouse models
    • Aydin D, Weyer SW, Muller UC. 2012. Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res 217:423–434.
    • (2012) Exp Brain Res , vol.217 , pp. 423-434
    • Aydin, D.1    Weyer, S.W.2    Muller, U.C.3
  • 8
    • 84863242859 scopus 로고    scopus 로고
    • Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-alpha: implications for autism
    • Bailey AR, Hou H, Obregon DF, Tian J, Zhu Y, Zou Q, Nikolic WV, Bengtson M, Mori T, Murphy T, Tan J. 2012. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-alpha: implications for autism. FASEB J 26:1040–1051.
    • (2012) FASEB J , vol.26 , pp. 1040-1051
    • Bailey, A.R.1    Hou, H.2    Obregon, D.F.3    Tian, J.4    Zhu, Y.5    Zou, Q.6    Nikolic, W.V.7    Bengtson, M.8    Mori, T.9    Murphy, T.10    Tan, J.11
  • 9
    • 33745793612 scopus 로고    scopus 로고
    • Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase. ADAM-10 and ADAM-17 cleavage of APP in human astrocytic cells involving p38 MAP kinase
    • Bandyopadhyay S, Hartley DM, Cahill CM, Lahiri DK, Chattopadhyay N, Rogers JT. 2006. Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase. ADAM-10 and ADAM-17 cleavage of APP in human astrocytic cells involving p38 MAP kinase. J Neurosci Res 84:106–118.
    • (2006) J Neurosci Res , vol.84 , pp. 106-118
    • Bandyopadhyay, S.1    Hartley, D.M.2    Cahill, C.M.3    Lahiri, D.K.4    Chattopadhyay, N.5    Rogers, J.T.6
  • 10
    • 0030610645 scopus 로고    scopus 로고
    • Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
    • Barger SW, Harmon AD. 1997. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878–881.
    • (1997) Nature , vol.388 , pp. 878-881
    • Barger, S.W.1    Harmon, A.D.2
  • 11
    • 0029120336 scopus 로고
    • The secreted form of the Alzheimer's beta-amyloid precursor protein stimulates a membrane-associated guanylate cyclase
    • Barger SW, Mattson MP. 1995. The secreted form of the Alzheimer's beta-amyloid precursor protein stimulates a membrane-associated guanylate cyclase. Biochem J 311(Pt 1):45–47.
    • (1995) Biochem J , vol.311 , pp. 45-47
    • Barger, S.W.1    Mattson, M.P.2
  • 12
    • 0028912956 scopus 로고
    • Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor
    • Barger SW, Fiscus RR, Ruth P, Hofmann F, Mattson MP. 1995. Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor. J Neurochem 64:2087–2096.
    • (1995) J Neurochem , vol.64 , pp. 2087-2096
    • Barger, S.W.1    Fiscus, R.R.2    Ruth, P.3    Hofmann, F.4    Mattson, M.P.5
  • 14
    • 0024449363 scopus 로고
    • The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein
    • Beisiegel U, Weber W, Ihrke G, Herz J, Stanley KK. 1989. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 341:162–164.
    • (1989) Nature , vol.341 , pp. 162-164
    • Beisiegel, U.1    Weber, W.2    Ihrke, G.3    Herz, J.4    Stanley, K.K.5
  • 15
  • 17
    • 7444253126 scopus 로고    scopus 로고
    • Cerebrospinal fluid protein biomarkers for Alzheimer's disease
    • Blennow K. 2004. Cerebrospinal fluid protein biomarkers for Alzheimer's disease. NeuroRx 1:213–225.
    • (2004) NeuroRx , vol.1 , pp. 213-225
    • Blennow, K.1
  • 18
    • 10044235332 scopus 로고    scopus 로고
    • Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK
    • Bodles AM, Barger SW. 2005. Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK. Neurobiol Aging 26:9–16.
    • (2005) Neurobiol Aging , vol.26 , pp. 9-16
    • Bodles, A.M.1    Barger, S.W.2
  • 19
    • 0344255830 scopus 로고    scopus 로고
    • A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice
    • Bour A, Little S, Dodart JC, Kelche C, Mathis C. 2004. A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice. Neurobiol Learn Mem 81:27–38.
    • (2004) Neurobiol Learn Mem , vol.81 , pp. 27-38
    • Bour, A.1    Little, S.2    Dodart, J.C.3    Kelche, C.4    Mathis, C.5
  • 20
    • 0028114869 scopus 로고
    • Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model
    • Bowes MP, Masliah E, Otero DA, Zivin JA, Saitoh T. 1994. Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model. Exp Neurol 129:112–119.
    • (1994) Exp Neurol , vol.129 , pp. 112-119
    • Bowes, M.P.1    Masliah, E.2    Otero, D.A.3    Zivin, J.A.4    Saitoh, T.5
  • 22
    • 2542519087 scopus 로고    scopus 로고
    • Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
    • Caille I, Allinquant B, Dupont E, Bouillot C, Langer A, Muller U, Prochiantz A. 2004. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131:2173–2181.
    • (2004) Development , vol.131 , pp. 2173-2181
    • Caille, I.1    Allinquant, B.2    Dupont, E.3    Bouillot, C.4    Langer, A.5    Muller, U.6    Prochiantz, A.7
  • 23
    • 0035372336 scopus 로고    scopus 로고
    • Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
    • Cedazo-Minguez A, Wiehager B, Winblad B, Huttinger M, Cowburn RF. 2001. Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. Neurochem Int 38:615–625.
    • (2001) Neurochem Int , vol.38 , pp. 615-625
    • Cedazo-Minguez, A.1    Wiehager, B.2    Winblad, B.3    Huttinger, M.4    Cowburn, R.F.5
  • 24
    • 79551546647 scopus 로고    scopus 로고
    • Secreted amyloid precursor protein beta and secreted amyloid precursor protein alpha induce axon outgrowth in vitro through Egr1 signaling pathway
    • Chasseigneaux S, Dinc L, Rose C, Chabret C, Coulpier F, Topilko P, Mauger G, Allinquant B. 2011. Secreted amyloid precursor protein beta and secreted amyloid precursor protein alpha induce axon outgrowth in vitro through Egr1 signaling pathway. PloS One 6:e16301.
    • (2011) PloS One , vol.6
    • Chasseigneaux, S.1    Dinc, L.2    Rose, C.3    Chabret, C.4    Coulpier, F.5    Topilko, P.6    Mauger, G.7    Allinquant, B.8
  • 25
    • 0036285116 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein
    • Cheng G, Yu Z, Zhou D, Mattson MP. 2002. Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein. Exp Neurol 175:407–414.
    • (2002) Exp Neurol , vol.175 , pp. 407-414
    • Cheng, G.1    Yu, Z.2    Zhou, D.3    Mattson, M.P.4
  • 27
    • 0028292343 scopus 로고
    • Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants
    • Clarris HJ, Nurcombe V, Small DH, Beyreuther K, Masters CL. 1994. Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants. J Neurosci Res 38:248–258.
    • (1994) J Neurosci Res , vol.38 , pp. 248-258
    • Clarris, H.J.1    Nurcombe, V.2    Small, D.H.3    Beyreuther, K.4    Masters, C.L.5
  • 30
    • 79951946382 scopus 로고    scopus 로고
    • The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains
    • Corrigan F, Pham CL, Vink R, Blumbergs PC, Masters CL, van den Heuvel C, Cappai R. 2011. The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains. Brain Res 1378:137–143.
    • (2011) Brain Res , vol.1378 , pp. 137-143
    • Corrigan, F.1    Pham, C.L.2    Vink, R.3    Blumbergs, P.C.4    Masters, C.L.5    van den Heuvel, C.6    Cappai, R.7
  • 31
    • 84862230016 scopus 로고    scopus 로고
    • sAPPalpha rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury
    • Corrigan F, Vink R, Blumbergs PC, Masters CL, Cappai R, van den Heuvel C. 2012. sAPPalpha rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury. J Neurochem 122:208–220.
    • (2012) J Neurochem , vol.122 , pp. 208-220
    • Corrigan, F.1    Vink, R.2    Blumbergs, P.C.3    Masters, C.L.4    Cappai, R.5    van den Heuvel, C.6
  • 32
    • 84890796720 scopus 로고    scopus 로고
    • The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96–110
    • Corrigan F, Thornton E, Roisman LC, Leonard AV, Vink R, Blumbergs PC, van den Heuvel C, Cappai R. 2014. The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96–110. J Neurochem 128:196–204.
    • (2014) J Neurochem , vol.128 , pp. 196-204
    • Corrigan, F.1    Thornton, E.2    Roisman, L.C.3    Leonard, A.V.4    Vink, R.5    Blumbergs, P.C.6    van den Heuvel, C.7    Cappai, R.8
  • 34
    • 77950385325 scopus 로고    scopus 로고
    • Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein
    • Dahms SO, Hoefgen S, Roeser D, Schlott B, Guhrs KH, Than ME. 2010. Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc Natl Acad Sci U S A 107:5381–5386.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5381-5386
    • Dahms, S.O.1    Hoefgen, S.2    Roeser, D.3    Schlott, B.4    Guhrs, K.H.5    Than, M.E.6
  • 35
    • 84924777819 scopus 로고    scopus 로고
    • Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes
    • Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME. 2015. Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. Acta Crystallogr D Biol Crystallogr 71:494–504.
    • (2015) Acta Crystallogr D Biol Crystallogr , vol.71 , pp. 494-504
    • Dahms, S.O.1    Mayer, M.C.2    Roeser, D.3    Multhaup, G.4    Than, M.E.5
  • 37
    • 76849086405 scopus 로고    scopus 로고
    • The secretases: enzymes with therapeutic potential in Alzheimer disease
    • De Strooper B, Vassar R, Golde T. 2010. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6:99–107.
    • (2010) Nat Rev Neurol , vol.6 , pp. 99-107
    • De Strooper, B.1    Vassar, R.2    Golde, T.3
  • 38
    • 0036830562 scopus 로고    scopus 로고
    • NTR: novel functions and implications for diseases of the nervous system
    • NTR: novel functions and implications for diseases of the nervous system. Nat Neurosci 5:1131–1136.
    • (2002) Nat Neurosci , vol.5 , pp. 1131-1136
    • Dechant, G.1    Barde, Y.A.2
  • 39
    • 0030513943 scopus 로고    scopus 로고
    • Structural correlates of cognition in dementia: quantification and assessment of synapse change
    • DeKosky ST, Scheff SW, Styren SD. 1996. Structural correlates of cognition in dementia: quantification and assessment of synapse change. Neurodegeneration 5:417–421.
    • (1996) Neurodegeneration , vol.5 , pp. 417-421
    • DeKosky, S.T.1    Scheff, S.W.2    Styren, S.D.3
  • 40
    • 80053918665 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
    • Demars MP, Bartholomew A, Strakova Z, Lazarov O. 2011. Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin. Stem Cell Res Ther 2:36.
    • (2011) Stem Cell Res Ther , vol.2 , pp. 36
    • Demars, M.P.1    Bartholomew, A.2    Strakova, Z.3    Lazarov, O.4
  • 41
    • 84945186786 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3beta signaling pathway
    • Deng J, Habib A, Obregon DF, Barger SW, Giunta B, Wang YJ, Hou H, Sawmiller D, Tan J. 2015. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3beta signaling pathway. J Neurochem 135:630–637.
    • (2015) J Neurochem , vol.135 , pp. 630-637
    • Deng, J.1    Habib, A.2    Obregon, D.F.3    Barger, S.W.4    Giunta, B.5    Wang, Y.J.6    Hou, H.7    Sawmiller, D.8    Tan, J.9
  • 43
    • 0025367968 scopus 로고
    • Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat
    • Doyle E, Bruce MT, Breen KC, Smith DC, Anderton B, Regan CM. 1990. Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat. Neurosci Lett 115:97–102.
    • (1990) Neurosci Lett , vol.115 , pp. 97-102
    • Doyle, E.1    Bruce, M.T.2    Breen, K.C.3    Smith, D.C.4    Anderton, B.5    Regan, C.M.6
  • 44
    • 0026034352 scopus 로고
    • NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway
    • East SJ, Garthwaite J. 1991. NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci Lett 123:17–19.
    • (1991) Neurosci Lett , vol.123 , pp. 17-19
    • East, S.J.1    Garthwaite, J.2
  • 45
    • 77949595824 scopus 로고    scopus 로고
    • Upregulation of the alpha-secretase ADAM10—risk or reason for hope?
    • Endres K, Fahrenholz F. 2010. Upregulation of the alpha-secretase ADAM10—risk or reason for hope? FEBS J 277:1585–1596.
    • (2010) FEBS J , vol.277 , pp. 1585-1596
    • Endres, K.1    Fahrenholz, F.2
  • 46
    • 84862850617 scopus 로고    scopus 로고
    • Regulation of alpha-secretase ADAM10 expression and activity
    • Endres K, Fahrenholz F. 2012. Regulation of alpha-secretase ADAM10 expression and activity. Exp Brain Res 217:343–352.
    • (2012) Exp Brain Res , vol.217 , pp. 343-352
    • Endres, K.1    Fahrenholz, F.2
  • 47
    • 33750156019 scopus 로고    scopus 로고
    • Alpha-secretase activation—an approach to Alzheimer's disease therapy
    • Fahrenholz F, Postina R. 2006. Alpha-secretase activation—an approach to Alzheimer's disease therapy. Neurodegen Dis 3:255–261.
    • (2006) Neurodegen Dis , vol.3 , pp. 255-261
    • Fahrenholz, F.1    Postina, R.2
  • 48
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM. 1997. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278:1349–1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6    Myers, R.H.7    Pericak-Vance, M.A.8    Risch, N.9    van Duijn, C.M.10
  • 49
    • 0027400856 scopus 로고
    • Changes in protein synthesis accompanying long-term potentiation in the dentate gyrus in vivo
    • Fazeli MS, Corbet J, Dunn MJ, Dolphin AC, Bliss TV. 1993. Changes in protein synthesis accompanying long-term potentiation in the dentate gyrus in vivo. J Neurosci 13:1346–1353.
    • (1993) J Neurosci , vol.13 , pp. 1346-1353
    • Fazeli, M.S.1    Corbet, J.2    Dunn, M.J.3    Dolphin, A.C.4    Bliss, T.V.5
  • 52
    • 79959910328 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells
    • Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. 2011. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem 286:24264–24274.
    • (2011) J Biol Chem , vol.286 , pp. 24264-24274
    • Freude, K.K.1    Penjwini, M.2    Davis, J.L.3    LaFerla, F.M.4    Blurton-Jones, M.5
  • 53
    • 0031905682 scopus 로고    scopus 로고
    • Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP
    • Furukawa K, Mattson MP. 1998. Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP. Neuroscience 83:429–438.
    • (1998) Neuroscience , vol.83 , pp. 429-438
    • Furukawa, K.1    Mattson, M.P.2
  • 54
    • 0030068094 scopus 로고    scopus 로고
    • + channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein
    • + channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature 379:74–78.
    • (1996) Nature , vol.379 , pp. 74-78
    • Furukawa, K.1    Barger, S.W.2    Blalock, E.M.3    Mattson, M.P.4
  • 55
    • 0029841562 scopus 로고    scopus 로고
    • Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain
    • Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M, Mattson MP. 1996b. Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem 67:1882–1896.
    • (1996) J Neurochem , vol.67 , pp. 1882-1896
    • Furukawa, K.1    Sopher, B.L.2    Rydel, R.E.3    Begley, J.G.4    Pham, D.G.5    Martin, G.M.6    Fox, M.7    Mattson, M.P.8
  • 56
    • 50449084262 scopus 로고    scopus 로고
    • Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway
    • Gakhar-Koppole N, Hundeshagen P, Mandl C, Weyer SW, Allinquant B, Muller U, Ciccolini F. 2008. Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. Eur J Neurosci 28:871–882.
    • (2008) Eur J Neurosci , vol.28 , pp. 871-882
    • Gakhar-Koppole, N.1    Hundeshagen, P.2    Mandl, C.3    Weyer, S.W.4    Allinquant, B.5    Muller, U.6    Ciccolini, F.7
  • 57
    • 0024431373 scopus 로고
    • Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization
    • Ghiso J, Tagliavini F, Timmers WF, Frangione B. 1989. Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization. Biochem Biophys Res Commun 163:430–437.
    • (1989) Biochem Biophys Res Commun , vol.163 , pp. 430-437
    • Ghiso, J.1    Tagliavini, F.2    Timmers, W.F.3    Frangione, B.4
  • 59
    • 0028169905 scopus 로고
    • Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury
    • Goodman Y, Mattson MP. 1994. Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol 128:1–12.
    • (1994) Exp Neurol , vol.128 , pp. 1-12
    • Goodman, Y.1    Mattson, M.P.2
  • 60
    • 0036674604 scopus 로고    scopus 로고
    • The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system
    • Goto JJ, Tanzi RE. 2002. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. J Mol Neurosci 19:37–41.
    • (2002) J Mol Neurosci , vol.19 , pp. 37-41
    • Goto, J.J.1    Tanzi, R.E.2
  • 62
    • 67649366042 scopus 로고    scopus 로고
    • Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers
    • Gralle M, Botelho MG, Wouters FS. 2009. Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem 284:15016–15025.
    • (2009) J Biol Chem , vol.284 , pp. 15016-15025
    • Gralle, M.1    Botelho, M.G.2    Wouters, F.S.3
  • 63
    • 0028980795 scopus 로고
    • Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase
    • Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. 1995. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett 198:52–56.
    • (1995) Neurosci Lett , vol.198 , pp. 52-56
    • Greenberg, S.M.1    Qiu, W.Q.2    Selkoe, D.J.3    Ben-Itzhak, A.4    Kosik, K.S.5
  • 64
    • 0032524319 scopus 로고    scopus 로고
    • Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis
    • Guo Q, Robinson N, Mattson MP. 1998. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. J Biol Chem 273:12341–12351.
    • (1998) J Biol Chem , vol.273 , pp. 12341-12351
    • Guo, Q.1    Robinson, N.2    Mattson, M.P.3
  • 65
    • 84862953172 scopus 로고    scopus 로고
    • Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives
    • Guo Q, Li H, Gaddam SS, Justice NJ, Robertson CS, Zheng H. 2012a. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem 287:2437–2445.
    • (2012) J Biol Chem , vol.287 , pp. 2437-2445
    • Guo, Q.1    Li, H.2    Gaddam, S.S.3    Justice, N.J.4    Robertson, C.S.5    Zheng, H.6
  • 66
    • 84855483701 scopus 로고    scopus 로고
    • APP physiological and pathophysiological functions: insights from animal models
    • Guo Q, Wang Z, Li H, Wiese M, Zheng H. 2012b. APP physiological and pathophysiological functions: insights from animal models. Cell Res 22:78–89.
    • (2012) Cell Res , vol.22 , pp. 78-89
    • Guo, Q.1    Wang, Z.2    Li, H.3    Wiese, M.4    Zheng, H.5
  • 68
    • 0027333557 scopus 로고
    • Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
    • Haass C, Selkoe DJ. 1993. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75:1039–1042.
    • (1993) Cell , vol.75 , pp. 1039-1042
    • Haass, C.1    Selkoe, D.J.2
  • 69
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. 1991. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12:383–388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 72
    • 84892752054 scopus 로고    scopus 로고
    • Soluble beta-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth
    • Hasebe N, Fujita Y, Ueno M, Yoshimura K, Fujino Y, Yamashita T. 2013. Soluble beta-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PloS One 8:e82321.
    • (2013) PloS One , vol.8
    • Hasebe, N.1    Fujita, Y.2    Ueno, M.3    Yoshimura, K.4    Fujino, Y.5    Yamashita, T.6
  • 76
    • 84902096534 scopus 로고    scopus 로고
    • Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain
    • Hoefgen S, Coburger I, Roeser D, Schaub Y, Dahms SO, Than ME. 2014. Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain. J Struct Biol 187:30–37.
    • (2014) J Struct Biol , vol.187 , pp. 30-37
    • Hoefgen, S.1    Coburger, I.2    Roeser, D.3    Schaub, Y.4    Dahms, S.O.5    Than, M.E.6
  • 77
    • 0032992044 scopus 로고    scopus 로고
    • Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces
    • Hoffmann J, Pietrzik CU, Kummer MP, Twiesselmann C, Bauer C, Herzog V. 1999. Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces. J Histochen Cytochem 47:373–382.
    • (1999) J Histochen Cytochem , vol.47 , pp. 373-382
    • Hoffmann, J.1    Pietrzik, C.U.2    Kummer, M.P.3    Twiesselmann, C.4    Bauer, C.5    Herzog, V.6
  • 80
    • 0032732224 scopus 로고    scopus 로고
    • Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors
    • Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L. 1999. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol 155:1741–1747.
    • (1999) Am J Pathol , vol.155 , pp. 1741-1747
    • Huang, F.1    Buttini, M.2    Wyss-Coray, T.3    McConlogue, L.4    Kodama, T.5    Pitas, R.E.6    Mucke, L.7
  • 81
    • 0027409609 scopus 로고
    • Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach
    • Huber G, Martin JR, Loffler J, Moreau JL. 1993. Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach. Brain Res 603:348–352.
    • (1993) Brain Res , vol.603 , pp. 348-352
    • Huber, G.1    Martin, J.R.2    Loffler, J.3    Moreau, J.L.4
  • 82
    • 0030763739 scopus 로고    scopus 로고
    • Synaptic beta-amyloid precursor proteins increase with learning capacity in rats
    • Huber G, Bailly Y, Martin JR, Mariani J, Brugg B. 1997. Synaptic beta-amyloid precursor proteins increase with learning capacity in rats. Neuroscience 80:313–320.
    • (1997) Neuroscience , vol.80 , pp. 313-320
    • Huber, G.1    Bailly, Y.2    Martin, J.R.3    Mariani, J.4    Brugg, B.5
  • 83
    • 0030797332 scopus 로고    scopus 로고
    • Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices
    • Ishida A, Furukawa K, Keller JN, Mattson MP. 1997. Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices. Neuroreport 8:2133–2137.
    • (1997) Neuroreport , vol.8 , pp. 2133-2137
    • Ishida, A.1    Furukawa, K.2    Keller, J.N.3    Mattson, M.P.4
  • 84
    • 84873715194 scopus 로고    scopus 로고
    • Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder
    • Jakobsson J, Zetterberg H, Blennow K, Johan Ekman C, Johansson AG, Landen M. 2013. Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder. Neuropsychopharmacology 38:664–672.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 664-672
    • Jakobsson, J.1    Zetterberg, H.2    Blennow, K.3    Johan Ekman, C.4    Johansson, A.G.5    Landen, M.6
  • 86
    • 79956320988 scopus 로고    scopus 로고
    • Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model
    • Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J. 2011. Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. J Biol Chem 286:18414–18425.
    • (2011) J Biol Chem , vol.286 , pp. 18414-18425
    • Jimenez, S.1    Torres, M.2    Vizuete, M.3    Sanchez-Varo, R.4    Sanchez-Mejias, E.5    Trujillo-Estrada, L.6    Carmona-Cuenca, I.7    Caballero, C.8    Ruano, D.9    Gutierrez, A.10    Vitorica, J.11
  • 87
    • 0028136865 scopus 로고
    • Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension
    • Jin LW, Ninomiya H, Roch JM, Schubert D, Masliah E, Otero DA, Saitoh T. 1994. Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J Neurosci 14:5461–5470.
    • (1994) J Neurosci , vol.14 , pp. 5461-5470
    • Jin, L.W.1    Ninomiya, H.2    Roch, J.M.3    Schubert, D.4    Masliah, E.5    Otero, D.A.6    Saitoh, T.7
  • 88
    • 84862837302 scopus 로고    scopus 로고
    • Role of APP for dendritic spine formation and stability
    • Jung CK, Herms J. 2012. Role of APP for dendritic spine formation and stability. Exp Brain Res 217:463–470.
    • (2012) Exp Brain Res , vol.217 , pp. 463-470
    • Jung, C.K.1    Herms, J.2
  • 89
  • 90
    • 84901341240 scopus 로고    scopus 로고
    • The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease
    • Kanekiyo T, Bu G. 2014. The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease. Front Aging Neurosci 6:93.
    • (2014) Front Aging Neurosci , vol.6 , pp. 93
    • Kanekiyo, T.1    Bu, G.2
  • 94
    • 0030592750 scopus 로고    scopus 로고
    • Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)
    • Knauer MF, Orlando RA, Glabe CG. 1996. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). Brain Res 740:6–14.
    • (1996) Brain Res , vol.740 , pp. 6-14
    • Knauer, M.F.1    Orlando, R.A.2    Glabe, C.G.3
  • 96
    • 11844251260 scopus 로고    scopus 로고
    • Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway
    • Kogel D, Schomburg R, Copanaki E, Prehn JH. 2005. Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. Cell Death Differ 12:1–9.
    • (2005) Cell Death Differ , vol.12 , pp. 1-9
    • Kogel, D.1    Schomburg, R.2    Copanaki, E.3    Prehn, J.H.4
  • 97
    • 0029128232 scopus 로고
    • LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation
    • Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. 1995. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 82:331–340.
    • (1995) Cell , vol.82 , pp. 331-340
    • Kounnas, M.Z.1    Moir, R.D.2    Rebeck, G.W.3    Bush, A.I.4    Argraves, W.S.5    Tanzi, R.E.6    Hyman, B.T.7    Strickland, D.K.8
  • 99
    • 0028982840 scopus 로고
    • Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease
    • Lannfelt L, Basun H, Wahlund LO, Rowe BA, Wagner SL. 1995. Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease. Nat Med 1:829–832.
    • (1995) Nat Med , vol.1 , pp. 829-832
    • Lannfelt, L.1    Basun, H.2    Wahlund, L.O.3    Rowe, B.A.4    Wagner, S.L.5
  • 101
    • 0030951506 scopus 로고    scopus 로고
    • Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease
    • Li HL, Roch JM, Sundsmo M, Otero D, Sisodia S, Thomas R, Saitoh T. 1997. Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease. J Neurobiol 32:469–480.
    • (1997) J Neurobiol , vol.32 , pp. 469-480
    • Li, H.L.1    Roch, J.M.2    Sundsmo, M.3    Otero, D.4    Sisodia, S.5    Thomas, R.6    Saitoh, T.7
  • 102
    • 78049267204 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
    • Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Sudhof TC, Zheng H. 2010. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A 107:17362–17367.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17362-17367
    • Li, H.1    Wang, B.2    Wang, Z.3    Guo, Q.4    Tabuchi, K.5    Hammer, R.E.6    Sudhof, T.C.7    Zheng, H.8
  • 103
    • 84873722367 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
    • Liu CC, Kanekiyo T, Xu H, Bu G. 2013. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 9:106–118.
    • (2013) Nat Rev Neurol , vol.9 , pp. 106-118
    • Liu, C.C.1    Kanekiyo, T.2    Xu, H.3    Bu, G.4
  • 104
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein
    • Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10:243–254.
    • (1993) Neuron , vol.10 , pp. 243-254
    • Mattson, M.P.1    Cheng, B.2    Culwell, A.R.3    Esch, F.S.4    Lieberburg, I.5    Rydel, R.E.6
  • 105
    • 0030611750 scopus 로고    scopus 로고
    • Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
    • Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K. 1997. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681–697.
    • (1997) J Neurosci Res , vol.49 , pp. 681-697
    • Mattson, M.P.1    Goodman, Y.2    Luo, H.3    Fu, W.4    Furukawa, K.5
  • 106
    • 0030048606 scopus 로고    scopus 로고
    • Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction
    • Maurice T, Lockhart BP, Privat A. 1996. Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 706:181–193.
    • (1996) Brain Res , vol.706 , pp. 181-193
    • Maurice, T.1    Lockhart, B.P.2    Privat, A.3
  • 107
  • 110
    • 0026663993 scopus 로고
    • The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth
    • Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther K, Masters CL. 1992. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9:129–137.
    • (1992) Neuron , vol.9 , pp. 129-137
    • Milward, E.A.1    Papadopoulos, R.2    Fuller, S.J.3    Moir, R.D.4    Small, D.5    Beyreuther, K.6    Masters, C.L.7
  • 111
    • 84872407604 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein alpha in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus
    • Miyajima M, Nakajima M, Ogino I, Miyata H, Motoi Y, Arai H. 2013. Soluble amyloid precursor protein alpha in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus. Eur J Neurol 20:236–242.
    • (2013) Eur J Neurol , vol.20 , pp. 236-242
    • Miyajima, M.1    Nakajima, M.2    Ogino, I.3    Miyata, H.4    Motoi, Y.5    Arai, H.6
  • 112
    • 20844433715 scopus 로고    scopus 로고
    • LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP
    • Moir RD, Tanzi RE. 2005. LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP. Curr Alzheimer Res 2:269–273.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 269-273
    • Moir, R.D.1    Tanzi, R.E.2
  • 114
    • 84946015384 scopus 로고    scopus 로고
    • sAbetaPPalpha improves hippocampal NMDA-dependent functional alterations linked to healthy aging
    • Moreno L, Rose C, Mohanraj A, Allinquant B, Billard JM, Dutar P. 2015. sAbetaPPalpha improves hippocampal NMDA-dependent functional alterations linked to healthy aging. J Alzheimers Dis 48:927–935.
    • (2015) J Alzheimers Dis , vol.48 , pp. 927-935
    • Moreno, L.1    Rose, C.2    Mohanraj, A.3    Allinquant, B.4    Billard, J.M.5    Dutar, P.6
  • 117
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M. 2009. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981–989.
    • (2009) Nature , vol.457 , pp. 981-989
    • Nikolaev, A.1    McLaughlin, T.2    O'Leary, D.D.3    Tessier-Lavigne, M.4
  • 119
    • 0027221517 scopus 로고
    • Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth
    • Ninomiya H, Roch JM, Sundsmo MP, Otero DA, Saitoh T. 1993. Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth. J Cell Biol 121:879–886.
    • (1993) J Cell Biol , vol.121 , pp. 879-886
    • Ninomiya, H.1    Roch, J.M.2    Sundsmo, M.P.3    Otero, D.A.4    Saitoh, T.5
  • 121
    • 0033012984 scopus 로고    scopus 로고
    • Amino–terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells
    • Ohsawa I, Takamura C, Morimoto T, Ishiguro M, Kohsaka S. 1999. Amino–terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur J Neurosci 11:1907–1913.
    • (1999) Eur J Neurosci , vol.11 , pp. 1907-1913
    • Ohsawa, I.1    Takamura, C.2    Morimoto, T.3    Ishiguro, M.4    Kohsaka, S.5
  • 122
    • 0035096910 scopus 로고    scopus 로고
    • Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function
    • Ohsawa I, Takamura C, Kohsaka S. 2001. Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function. J Neurochem 76:1411–1420.
    • (2001) J Neurochem , vol.76 , pp. 1411-1420
    • Ohsawa, I.1    Takamura, C.2    Kohsaka, S.3
  • 123
    • 0025302430 scopus 로고
    • Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease
    • Palmert MR, Usiak M, Mayeux R, Raskind M, Tourtellotte WW, Younkin SG. 1990. Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Neurology 40:1028–1034.
    • (1990) Neurology , vol.40 , pp. 1028-1034
    • Palmert, M.R.1    Usiak, M.2    Mayeux, R.3    Raskind, M.4    Tourtellotte, W.W.5    Younkin, S.G.6
  • 124
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid–beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
    • Palop JJ, Mucke L. 2010. Amyloid–beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci 13:812–818.
    • (2010) Nat Neurosci , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 126
    • 69249117009 scopus 로고    scopus 로고
    • ADAM9 as a potential target molecule in cancer
    • Peduto L. 2009. ADAM9 as a potential target molecule in cancer. Curr Pharm Des 15:2282–2287.
    • (2009) Curr Pharm Des , vol.15 , pp. 2282-2287
    • Peduto, L.1
  • 127
    • 0031453752 scopus 로고    scopus 로고
    • The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity
    • Perez RG, Zheng H, Van der Ploeg LH, Koo EH. 1997. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17:9407–9414.
    • (1997) J Neurosci , vol.17 , pp. 9407-9414
    • Perez, R.G.1    Zheng, H.2    Van der Ploeg, L.H.3    Koo, E.H.4
  • 131
    • 0032539666 scopus 로고    scopus 로고
    • From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells
    • Pietrzik CU, Hoffmann J, Stober K, Chen CY, Bauer C, Otero DA, Roch JM, Herzog V. 1998. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc Natl Acad Sci U S A 95:1770–1775.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 1770-1775
    • Pietrzik, C.U.1    Hoffmann, J.2    Stober, K.3    Chen, C.Y.4    Bauer, C.5    Otero, D.A.6    Roch, J.M.7    Herzog, V.8
  • 132
    • 69949132002 scopus 로고    scopus 로고
    • Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells
    • Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS. 2009. Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. J Biol Chem 284:23806–23817.
    • (2009) J Biol Chem , vol.284 , pp. 23806-23817
    • Porayette, P.1    Gallego, M.J.2    Kaltcheva, M.M.3    Bowen, R.L.4    Vadakkadath Meethal, S.5    Atwood, C.S.6
  • 134
    • 0029257190 scopus 로고
    • Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
    • Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. 1995. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 15:2157–2167.
    • (1995) J Neurosci , vol.15 , pp. 2157-2167
    • Qiu, W.Q.1    Ferreira, A.2    Miller, C.3    Koo, E.H.4    Selkoe, D.J.5
  • 135
    • 79959407483 scopus 로고    scopus 로고
    • Increased secreted amyloid precursor protein-alpha (sAPPalpha) in severe autism: proposal of a specific, anabolic pathway and putative biomarker
    • Ray B, Long JM, Sokol DK, Lahiri DK. 2011. Increased secreted amyloid precursor protein-alpha (sAPPalpha) in severe autism: proposal of a specific, anabolic pathway and putative biomarker. PloS One 6:e20405.
    • (2011) PloS One , vol.6
    • Ray, B.1    Long, J.M.2    Sokol, D.K.3    Lahiri, D.K.4
  • 136
    • 84887574873 scopus 로고    scopus 로고
    • Soluble amyloid-beta precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans
    • Reinhard C, Borgers M, David G, De Strooper B. 2013. Soluble amyloid-beta precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans. J Cell Sci 126:4856–4861.
    • (2013) J Cell Sci , vol.126 , pp. 4856-4861
    • Reinhard, C.1    Borgers, M.2    David, G.3    De Strooper, B.4
  • 138
    • 0028071334 scopus 로고
    • Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor
    • Roch JM, Masliah E, Roch-Levecq AC, Sundsmo MP, Otero DA, Veinbergs I, Saitoh T. 1994. Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc Natl Acad Sci U S A 91:7450–7454.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7450-7454
    • Roch, J.M.1    Masliah, E.2    Roch-Levecq, A.C.3    Sundsmo, M.P.4    Otero, D.A.5    Veinbergs, I.6    Saitoh, T.7
  • 142
    • 79955470772 scopus 로고    scopus 로고
    • The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: novel drug targets with therapeutic potential?
    • Saftig P, Reiss K. 2011. The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: novel drug targets with therapeutic potential? Eur J Cell Biol 90:527–535.
    • (2011) Eur J Cell Biol , vol.90 , pp. 527-535
    • Saftig, P.1    Reiss, K.2
  • 143
  • 144
    • 0028445312 scopus 로고
    • Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons
    • Salbaum JM, Ruddle FH. 1994. Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons. J Exp Zool 269:116–127.
    • (1994) J Exp Zool , vol.269 , pp. 116-127
    • Salbaum, J.M.1    Ruddle, F.H.2
  • 145
    • 0035903204 scopus 로고    scopus 로고
    • Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor
    • Santiago-Garcia J, Mas-Oliva J, Innerarity TL, Pitas RE. 2001. Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor. J Biol Chem 276:30655–30661.
    • (2001) J Biol Chem , vol.276 , pp. 30655-30661
    • Santiago-Garcia, J.1    Mas-Oliva, J.2    Innerarity, T.L.3    Pitas, R.E.4
  • 150
    • 0033987298 scopus 로고    scopus 로고
    • Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients
    • Sennvik K, Fastbom J, Blomberg M, Wahlund LO, Winblad B, Benedikz E. 2000. Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett 278:169–172.
    • (2000) Neurosci Lett , vol.278 , pp. 169-172
    • Sennvik, K.1    Fastbom, J.2    Blomberg, M.3    Wahlund, L.O.4    Winblad, B.5    Benedikz, E.6
  • 151
    • 0028213567 scopus 로고
    • A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
    • Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL. 1994. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci 14:2117–2127.
    • (1994) J Neurosci , vol.14 , pp. 2117-2127
    • Small, D.H.1    Nurcombe, V.2    Reed, G.3    Clarris, H.4    Moir, R.5    Beyreuther, K.6    Masters, C.L.7
  • 155
    • 85011738907 scopus 로고    scopus 로고
    • Enhancement of sAPPα as a therapeutic strategy for Alzheimer's and other neurodegenerative diseases
    • Spilman P, Bredesen D, Jagodzinska B, John V. 2015. Enhancement of sAPPα as a therapeutic strategy for Alzheimer's and other neurodegenerative diseases. HOSA J Alzheimers Neurodegen Dis 1:10.
    • (2015) HOSA J Alzheimers Neurodegen Dis , vol.1 , pp. 10
    • Spilman, P.1    Bredesen, D.2    Jagodzinska, B.3    John, V.4
  • 156
    • 4444255624 scopus 로고    scopus 로고
    • Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis
    • Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA. 2004. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 24:7707–7717.
    • (2004) J Neurosci , vol.24 , pp. 7707-7717
    • Stein, T.D.1    Anders, N.J.2    DeCarli, C.3    Chan, S.L.4    Mattson, M.P.5    Johnson, J.A.6
  • 159
    • 48749121982 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death
    • Taylor AL, Bonventre JV, Uliasz TF, Hewett JA, Hewett SJ. 2008. Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death. J Neurochem 106:1828–1840.
    • (2008) J Neurochem , vol.106 , pp. 1828-1840
    • Taylor, A.L.1    Bonventre, J.V.2    Uliasz, T.F.3    Hewett, J.A.4    Hewett, S.J.5
  • 160
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. 1991. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572–580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 161
    • 33745263255 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats
    • Thornton E, Vink R, Blumbergs PC, Van Den Heuvel C. 2006. Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats. Brain Res 1094:38–46.
    • (2006) Brain Res , vol.1094 , pp. 38-46
    • Thornton, E.1    Vink, R.2    Blumbergs, P.C.3    Van Den Heuvel, C.4
  • 162
    • 0042634362 scopus 로고    scopus 로고
    • Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
    • Turner PR, O'Connor K, Tate WP, Abraham WC. 2003. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1–32.
    • (2003) Prog Neurobiol , vol.70 , pp. 1-32
    • Turner, P.R.1    O'Connor, K.2    Tate, W.P.3    Abraham, W.C.4
  • 164
    • 79955655453 scopus 로고    scopus 로고
    • Activation of the alpha-secretase processing of AbetaPP as a therapeutic approach in Alzheimer's disease
    • Vincent B, Govitrapong P. 2011. Activation of the alpha-secretase processing of AbetaPP as a therapeutic approach in Alzheimer's disease. J Alzheimers Dis 24(Suppl 2):75–94.
    • (2011) J Alzheimers Dis , vol.24 , pp. 75-94
    • Vincent, B.1    Govitrapong, P.2
  • 165
    • 0034889517 scopus 로고    scopus 로고
    • Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
    • Vincent B, Smith JD. 2001. Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner. Eur J Neurosci 14:256–266.
    • (2001) Eur J Neurosci , vol.14 , pp. 256-266
    • Vincent, B.1    Smith, J.D.2
  • 166
    • 4143105782 scopus 로고    scopus 로고
    • The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain
    • Wang Y, Ha Y. 2004. The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol Cell 15:343–353.
    • (2004) Mol Cell , vol.15 , pp. 343-353
    • Wang, Y.1    Ha, Y.2
  • 167
    • 0024550204 scopus 로고
    • Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
    • Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K. 1989. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57:115–126.
    • (1989) Cell , vol.57 , pp. 115-126
    • Weidemann, A.1    Konig, G.2    Bunke, D.3    Fischer, P.4    Salbaum, J.M.5    Masters, C.L.6    Beyreuther, K.7
  • 169
    • 0025095256 scopus 로고
    • Beta-amyloid protein promotes neuritic branching in hippocampal cultures
    • Whitson JS, Glabe CG, Shintani E, Abcar A, Cotman CW. 1990. Beta-amyloid protein promotes neuritic branching in hippocampal cultures. Neurosci Lett 110:319–324.
    • (1990) Neurosci Lett , vol.110 , pp. 319-324
    • Whitson, J.S.1    Glabe, C.G.2    Shintani, E.3    Abcar, A.4    Cotman, C.W.5
  • 171
    • 77954176653 scopus 로고    scopus 로고
    • Memory formation and long-term retention in humans and animals: convergence toward a transformation account of hippocampal-neocortical interactions
    • Winocur G, Moscovitch M, Bontempi B. 2010. Memory formation and long-term retention in humans and animals: convergence toward a transformation account of hippocampal-neocortical interactions. Neuropsychologia 48:2339–2356.
    • (2010) Neuropsychologia , vol.48 , pp. 2339-2356
    • Winocur, G.1    Moscovitch, M.2    Bontempi, B.3
  • 172
    • 84936145573 scopus 로고    scopus 로고
    • Astrocytes regulate alpha-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: involvement of group IIA secretory phospholipase A2
    • Yang X, Sheng W, Ridgley DM, Haidekker MA, Sun GY, Lee JC. 2015. Astrocytes regulate alpha-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: involvement of group IIA secretory phospholipase A2. Neuroscience 300:508–517.
    • (2015) Neuroscience , vol.300 , pp. 508-517
    • Yang, X.1    Sheng, W.2    Ridgley, D.M.3    Haidekker, M.A.4    Sun, G.Y.5    Lee, J.C.6
  • 173
    • 46149126877 scopus 로고    scopus 로고
    • Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
    • Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. 2008. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev 3:15.
    • (2008) Neural Dev , vol.3 , pp. 15
    • Young-Pearse, T.L.1    Chen, A.C.2    Chang, R.3    Marquez, C.4    Selkoe, D.J.5
  • 174
    • 0028945660 scopus 로고
    • Evidence that Aβ42 is the real culprit in Alzheimer's disease
    • Younkin SG. 1995. Evidence that Aβ42 is the real culprit in Alzheimer's disease. Ann Neurol 37:287–288.
    • (1995) Ann Neurol , vol.37 , pp. 287-288
    • Younkin, S.G.1
  • 175
    • 66049148147 scopus 로고    scopus 로고
    • Biological CSF markers of Alzheimer's disease
    • Zetterberg H, Blennow K. 2008. Biological CSF markers of Alzheimer's disease. Hndbk Clin Neurol 89:261–268.
    • (2008) Hndbk Clin Neurol , vol.89 , pp. 261-268
    • Zetterberg, H.1    Blennow, K.2
  • 178
    • 0028275855 scopus 로고
    • Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
    • Zhuo M, Hu Y, Schultz C, Kandel ER, Hawkins RD. 1994. Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368:635–639.
    • (1994) Nature , vol.368 , pp. 635-639
    • Zhuo, M.1    Hu, Y.2    Schultz, C.3    Kandel, E.R.4    Hawkins, R.D.5


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