-
1
-
-
0030974261
-
Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation
-
Almkvist O, Basun H, Wagner SL, Rowe BA, Wahlund LO, Lannfelt L. 1997. Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. Arch Neurol 54:641–644.
-
(1997)
Arch Neurol
, vol.54
, pp. 641-644
-
-
Almkvist, O.1
Basun, H.2
Wagner, S.L.3
Rowe, B.A.4
Wahlund, L.O.5
Lannfelt, L.6
-
2
-
-
33644516276
-
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11
-
Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT, Cappai R, Willnow TE. 2006. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry 45:2618–2628.
-
(2006)
Biochemistry
, vol.45
, pp. 2618-2628
-
-
Andersen, O.M.1
Schmidt, V.2
Spoelgen, R.3
Gliemann, J.4
Behlke, J.5
Galatis, D.6
McKinstry, W.J.7
Parker, M.W.8
Masters, C.L.9
Hyman, B.T.10
Cappai, R.11
Willnow, T.E.12
-
3
-
-
0032768748
-
Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits
-
Anderson J, Holtz G, Baskin P, Wang R, Mazzarelli L, Wagner S, Menzaghi F. 1999. Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits. Neuroscience 93:1409–1420.
-
(1999)
Neuroscience
, vol.93
, pp. 1409-1420
-
-
Anderson, J.1
Holtz, G.2
Baskin, P.3
Wang, R.4
Mazzarelli, L.5
Wagner, S.6
Menzaghi, F.7
-
4
-
-
0026318496
-
Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture
-
Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. 1991. Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochem Biophys Res Commun 181:265–271.
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 265-271
-
-
Araki, W.1
Kitaguchi, N.2
Tokushima, Y.3
Ishii, K.4
Aratake, H.5
Shimohama, S.6
Nakamura, S.7
Kimura, J.8
-
5
-
-
0035139252
-
Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation
-
Arancio O, Antonova I, Gambaryan S, Lohmann SM, Wood JS, Lawrence DS, Hawkins RD. 2001. Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation. J Neurosci 21:143–149.
-
(2001)
J Neurosci
, vol.21
, pp. 143-149
-
-
Arancio, O.1
Antonova, I.2
Gambaryan, S.3
Lohmann, S.M.4
Wood, J.S.5
Lawrence, D.S.6
Hawkins, R.D.7
-
6
-
-
84861721553
-
Functions of the APP gene family in the nervous system: insights from mouse models
-
Aydin D, Weyer SW, Muller UC. 2012. Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res 217:423–434.
-
(2012)
Exp Brain Res
, vol.217
, pp. 423-434
-
-
Aydin, D.1
Weyer, S.W.2
Muller, U.C.3
-
7
-
-
76749111279
-
Peripheral biomarkers in Autism: secreted amyloid precursor protein-alpha as a probable key player in early diagnosis
-
Bailey AR, Giunta BN, Obregon D, Nikolic WV, Tian J, Sanberg CD, Sutton DT, Tan J. 2008. Peripheral biomarkers in Autism: secreted amyloid precursor protein-alpha as a probable key player in early diagnosis. Int J Clin Exp Med 1:338–344.
-
(2008)
Int J Clin Exp Med
, vol.1
, pp. 338-344
-
-
Bailey, A.R.1
Giunta, B.N.2
Obregon, D.3
Nikolic, W.V.4
Tian, J.5
Sanberg, C.D.6
Sutton, D.T.7
Tan, J.8
-
8
-
-
84863242859
-
Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-alpha: implications for autism
-
Bailey AR, Hou H, Obregon DF, Tian J, Zhu Y, Zou Q, Nikolic WV, Bengtson M, Mori T, Murphy T, Tan J. 2012. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-alpha: implications for autism. FASEB J 26:1040–1051.
-
(2012)
FASEB J
, vol.26
, pp. 1040-1051
-
-
Bailey, A.R.1
Hou, H.2
Obregon, D.F.3
Tian, J.4
Zhu, Y.5
Zou, Q.6
Nikolic, W.V.7
Bengtson, M.8
Mori, T.9
Murphy, T.10
Tan, J.11
-
9
-
-
33745793612
-
Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase. ADAM-10 and ADAM-17 cleavage of APP in human astrocytic cells involving p38 MAP kinase
-
Bandyopadhyay S, Hartley DM, Cahill CM, Lahiri DK, Chattopadhyay N, Rogers JT. 2006. Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase. ADAM-10 and ADAM-17 cleavage of APP in human astrocytic cells involving p38 MAP kinase. J Neurosci Res 84:106–118.
-
(2006)
J Neurosci Res
, vol.84
, pp. 106-118
-
-
Bandyopadhyay, S.1
Hartley, D.M.2
Cahill, C.M.3
Lahiri, D.K.4
Chattopadhyay, N.5
Rogers, J.T.6
-
10
-
-
0030610645
-
Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
-
Barger SW, Harmon AD. 1997. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878–881.
-
(1997)
Nature
, vol.388
, pp. 878-881
-
-
Barger, S.W.1
Harmon, A.D.2
-
11
-
-
0029120336
-
The secreted form of the Alzheimer's beta-amyloid precursor protein stimulates a membrane-associated guanylate cyclase
-
Barger SW, Mattson MP. 1995. The secreted form of the Alzheimer's beta-amyloid precursor protein stimulates a membrane-associated guanylate cyclase. Biochem J 311(Pt 1):45–47.
-
(1995)
Biochem J
, vol.311
, pp. 45-47
-
-
Barger, S.W.1
Mattson, M.P.2
-
12
-
-
0028912956
-
Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor
-
Barger SW, Fiscus RR, Ruth P, Hofmann F, Mattson MP. 1995. Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor. J Neurochem 64:2087–2096.
-
(1995)
J Neurochem
, vol.64
, pp. 2087-2096
-
-
Barger, S.W.1
Fiscus, R.R.2
Ruth, P.3
Hofmann, F.4
Mattson, M.P.5
-
13
-
-
84905851549
-
Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain
-
Baumkotter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K, Kins S. 2014. Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain. J Neurosci 34:11159–11172.
-
(2014)
J Neurosci
, vol.34
, pp. 11159-11172
-
-
Baumkotter, F.1
Schmidt, N.2
Vargas, C.3
Schilling, S.4
Weber, R.5
Wagner, K.6
Fiedler, S.7
Klug, W.8
Radzimanowski, J.9
Nickolaus, S.10
Keller, S.11
Eggert, S.12
Wild, K.13
Kins, S.14
-
14
-
-
0024449363
-
The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein
-
Beisiegel U, Weber W, Ihrke G, Herz J, Stanley KK. 1989. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 341:162–164.
-
(1989)
Nature
, vol.341
, pp. 162-164
-
-
Beisiegel, U.1
Weber, W.2
Ihrke, G.3
Herz, J.4
Stanley, K.K.5
-
15
-
-
0028019733
-
Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS
-
Bell MD, Lopez-Gonzalez R, Lawson L, Hughes D, Fraser I, Gordon S, Perry VH. 1994. Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS. J Neurocytol 23:605–613.
-
(1994)
J Neurocytol
, vol.23
, pp. 605-613
-
-
Bell, M.D.1
Lopez-Gonzalez, R.2
Lawson, L.3
Hughes, D.4
Fraser, I.5
Gordon, S.6
Perry, V.H.7
-
16
-
-
84866893131
-
The metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species
-
Bien J, Jefferson T, Causevic M, Jumpertz T, Munter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU. 2012. The metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species. J Biol Chem 287:33304–33313.
-
(2012)
J Biol Chem
, vol.287
, pp. 33304-33313
-
-
Bien, J.1
Jefferson, T.2
Causevic, M.3
Jumpertz, T.4
Munter, L.5
Multhaup, G.6
Weggen, S.7
Becker-Pauly, C.8
Pietrzik, C.U.9
-
17
-
-
7444253126
-
Cerebrospinal fluid protein biomarkers for Alzheimer's disease
-
Blennow K. 2004. Cerebrospinal fluid protein biomarkers for Alzheimer's disease. NeuroRx 1:213–225.
-
(2004)
NeuroRx
, vol.1
, pp. 213-225
-
-
Blennow, K.1
-
18
-
-
10044235332
-
Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK
-
Bodles AM, Barger SW. 2005. Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK. Neurobiol Aging 26:9–16.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 9-16
-
-
Bodles, A.M.1
Barger, S.W.2
-
19
-
-
0344255830
-
A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice
-
Bour A, Little S, Dodart JC, Kelche C, Mathis C. 2004. A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice. Neurobiol Learn Mem 81:27–38.
-
(2004)
Neurobiol Learn Mem
, vol.81
, pp. 27-38
-
-
Bour, A.1
Little, S.2
Dodart, J.C.3
Kelche, C.4
Mathis, C.5
-
20
-
-
0028114869
-
Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model
-
Bowes MP, Masliah E, Otero DA, Zivin JA, Saitoh T. 1994. Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model. Exp Neurol 129:112–119.
-
(1994)
Exp Neurol
, vol.129
, pp. 112-119
-
-
Bowes, M.P.1
Masliah, E.2
Otero, D.A.3
Zivin, J.A.4
Saitoh, T.5
-
21
-
-
84877579899
-
Soluble amyloid precursor protein alpha and beta in CSF in Alzheimer's disease
-
Brinkmalm G, Brinkmalm A, Bourgeois P, Persson R, Hansson O, Portelius E, Mercken M, Andreasson U, Parent S, Lipari F, Ohrfelt A, Bjerke M, Minthon L, Zetterberg H, Blennow K, Nutu M. 2013. Soluble amyloid precursor protein alpha and beta in CSF in Alzheimer's disease. Brain Res 1513:117–126.
-
(2013)
Brain Res
, vol.1513
, pp. 117-126
-
-
Brinkmalm, G.1
Brinkmalm, A.2
Bourgeois, P.3
Persson, R.4
Hansson, O.5
Portelius, E.6
Mercken, M.7
Andreasson, U.8
Parent, S.9
Lipari, F.10
Ohrfelt, A.11
Bjerke, M.12
Minthon, L.13
Zetterberg, H.14
Blennow, K.15
Nutu, M.16
-
22
-
-
2542519087
-
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
-
Caille I, Allinquant B, Dupont E, Bouillot C, Langer A, Muller U, Prochiantz A. 2004. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131:2173–2181.
-
(2004)
Development
, vol.131
, pp. 2173-2181
-
-
Caille, I.1
Allinquant, B.2
Dupont, E.3
Bouillot, C.4
Langer, A.5
Muller, U.6
Prochiantz, A.7
-
23
-
-
0035372336
-
Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
-
Cedazo-Minguez A, Wiehager B, Winblad B, Huttinger M, Cowburn RF. 2001. Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. Neurochem Int 38:615–625.
-
(2001)
Neurochem Int
, vol.38
, pp. 615-625
-
-
Cedazo-Minguez, A.1
Wiehager, B.2
Winblad, B.3
Huttinger, M.4
Cowburn, R.F.5
-
24
-
-
79551546647
-
Secreted amyloid precursor protein beta and secreted amyloid precursor protein alpha induce axon outgrowth in vitro through Egr1 signaling pathway
-
Chasseigneaux S, Dinc L, Rose C, Chabret C, Coulpier F, Topilko P, Mauger G, Allinquant B. 2011. Secreted amyloid precursor protein beta and secreted amyloid precursor protein alpha induce axon outgrowth in vitro through Egr1 signaling pathway. PloS One 6:e16301.
-
(2011)
PloS One
, vol.6
-
-
Chasseigneaux, S.1
Dinc, L.2
Rose, C.3
Chabret, C.4
Coulpier, F.5
Topilko, P.6
Mauger, G.7
Allinquant, B.8
-
25
-
-
0036285116
-
Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein
-
Cheng G, Yu Z, Zhou D, Mattson MP. 2002. Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein. Exp Neurol 175:407–414.
-
(2002)
Exp Neurol
, vol.175
, pp. 407-414
-
-
Cheng, G.1
Yu, Z.2
Zhou, D.3
Mattson, M.P.4
-
26
-
-
67349151118
-
Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism
-
Claasen AM, Guevremont D, Mason-Parker SE, Bourne K, Tate WP, Abraham WC, Williams JM. 2009. Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neurosci Lett 460:92–96.
-
(2009)
Neurosci Lett
, vol.460
, pp. 92-96
-
-
Claasen, A.M.1
Guevremont, D.2
Mason-Parker, S.E.3
Bourne, K.4
Tate, W.P.5
Abraham, W.C.6
Williams, J.M.7
-
27
-
-
0028292343
-
Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants
-
Clarris HJ, Nurcombe V, Small DH, Beyreuther K, Masters CL. 1994. Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants. J Neurosci Res 38:248–258.
-
(1994)
J Neurosci Res
, vol.38
, pp. 248-258
-
-
Clarris, H.J.1
Nurcombe, V.2
Small, D.H.3
Beyreuther, K.4
Masters, C.L.5
-
28
-
-
0029027171
-
Beta-amyloid(1–40) effects on behavior and memory
-
Cleary J, Hittner JM, Semotuk M, Mantyh P, O'Hare E. 1995. Beta-amyloid(1–40) effects on behavior and memory. Brain Res 682:69–74.
-
(1995)
Brain Res
, vol.682
, pp. 69-74
-
-
Cleary, J.1
Hittner, J.M.2
Semotuk, M.3
Mantyh, P.4
O'Hare, E.5
-
29
-
-
77953958809
-
sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress
-
Copanaki E, Chang S, Vlachos A, Tschape JA, Muller UC, Kogel D, Deller T. 2010. sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress. Mol Cell Neurosci 44:386–393.
-
(2010)
Mol Cell Neurosci
, vol.44
, pp. 386-393
-
-
Copanaki, E.1
Chang, S.2
Vlachos, A.3
Tschape, J.A.4
Muller, U.C.5
Kogel, D.6
Deller, T.7
-
30
-
-
79951946382
-
The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains
-
Corrigan F, Pham CL, Vink R, Blumbergs PC, Masters CL, van den Heuvel C, Cappai R. 2011. The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains. Brain Res 1378:137–143.
-
(2011)
Brain Res
, vol.1378
, pp. 137-143
-
-
Corrigan, F.1
Pham, C.L.2
Vink, R.3
Blumbergs, P.C.4
Masters, C.L.5
van den Heuvel, C.6
Cappai, R.7
-
31
-
-
84862230016
-
sAPPalpha rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury
-
Corrigan F, Vink R, Blumbergs PC, Masters CL, Cappai R, van den Heuvel C. 2012. sAPPalpha rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury. J Neurochem 122:208–220.
-
(2012)
J Neurochem
, vol.122
, pp. 208-220
-
-
Corrigan, F.1
Vink, R.2
Blumbergs, P.C.3
Masters, C.L.4
Cappai, R.5
van den Heuvel, C.6
-
32
-
-
84890796720
-
The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96–110
-
Corrigan F, Thornton E, Roisman LC, Leonard AV, Vink R, Blumbergs PC, van den Heuvel C, Cappai R. 2014. The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96–110. J Neurochem 128:196–204.
-
(2014)
J Neurochem
, vol.128
, pp. 196-204
-
-
Corrigan, F.1
Thornton, E.2
Roisman, L.C.3
Leonard, A.V.4
Vink, R.5
Blumbergs, P.C.6
van den Heuvel, C.7
Cappai, R.8
-
33
-
-
84964695079
-
Heteromers of amyloid precursor protein in cerebrospinal fluid
-
Cuchillo-Ibanez I, Lopez-Font I, Boix-Amoros A, Brinkmalm G, Blennow K, Molinuevo JL, Saez-Valero J. 2015. Heteromers of amyloid precursor protein in cerebrospinal fluid. Mol Neurodegen 10:2.
-
(2015)
Mol Neurodegen
, vol.10
, pp. 2
-
-
Cuchillo-Ibanez, I.1
Lopez-Font, I.2
Boix-Amoros, A.3
Brinkmalm, G.4
Blennow, K.5
Molinuevo, J.L.6
Saez-Valero, J.7
-
34
-
-
77950385325
-
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein
-
Dahms SO, Hoefgen S, Roeser D, Schlott B, Guhrs KH, Than ME. 2010. Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc Natl Acad Sci U S A 107:5381–5386.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 5381-5386
-
-
Dahms, S.O.1
Hoefgen, S.2
Roeser, D.3
Schlott, B.4
Guhrs, K.H.5
Than, M.E.6
-
35
-
-
84924777819
-
Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes
-
Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME. 2015. Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. Acta Crystallogr D Biol Crystallogr 71:494–504.
-
(2015)
Acta Crystallogr D Biol Crystallogr
, vol.71
, pp. 494-504
-
-
Dahms, S.O.1
Mayer, M.C.2
Roeser, D.3
Multhaup, G.4
Than, M.E.5
-
36
-
-
84945936473
-
Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce amyloid-beta pathology in PSAPP mice
-
Darlington D, Li S, Hou H, Habib A, Tian J, Gao Y, Ehrhart J, Sanberg PR, Sawmiller D, Giunta B, Mori T, Tan J. 2015. Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce amyloid-beta pathology in PSAPP mice. Cell Transplant 24:2237–2250.
-
(2015)
Cell Transplant
, vol.24
, pp. 2237-2250
-
-
Darlington, D.1
Li, S.2
Hou, H.3
Habib, A.4
Tian, J.5
Gao, Y.6
Ehrhart, J.7
Sanberg, P.R.8
Sawmiller, D.9
Giunta, B.10
Mori, T.11
Tan, J.12
-
37
-
-
76849086405
-
The secretases: enzymes with therapeutic potential in Alzheimer disease
-
De Strooper B, Vassar R, Golde T. 2010. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6:99–107.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 99-107
-
-
De Strooper, B.1
Vassar, R.2
Golde, T.3
-
38
-
-
0036830562
-
NTR: novel functions and implications for diseases of the nervous system
-
NTR: novel functions and implications for diseases of the nervous system. Nat Neurosci 5:1131–1136.
-
(2002)
Nat Neurosci
, vol.5
, pp. 1131-1136
-
-
Dechant, G.1
Barde, Y.A.2
-
39
-
-
0030513943
-
Structural correlates of cognition in dementia: quantification and assessment of synapse change
-
DeKosky ST, Scheff SW, Styren SD. 1996. Structural correlates of cognition in dementia: quantification and assessment of synapse change. Neurodegeneration 5:417–421.
-
(1996)
Neurodegeneration
, vol.5
, pp. 417-421
-
-
DeKosky, S.T.1
Scheff, S.W.2
Styren, S.D.3
-
40
-
-
80053918665
-
Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
-
Demars MP, Bartholomew A, Strakova Z, Lazarov O. 2011. Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin. Stem Cell Res Ther 2:36.
-
(2011)
Stem Cell Res Ther
, vol.2
, pp. 36
-
-
Demars, M.P.1
Bartholomew, A.2
Strakova, Z.3
Lazarov, O.4
-
41
-
-
84945186786
-
Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3beta signaling pathway
-
Deng J, Habib A, Obregon DF, Barger SW, Giunta B, Wang YJ, Hou H, Sawmiller D, Tan J. 2015. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3beta signaling pathway. J Neurochem 135:630–637.
-
(2015)
J Neurochem
, vol.135
, pp. 630-637
-
-
Deng, J.1
Habib, A.2
Obregon, D.F.3
Barger, S.W.4
Giunta, B.5
Wang, Y.J.6
Hou, H.7
Sawmiller, D.8
Tan, J.9
-
42
-
-
33748536734
-
LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease
-
Dodson SE, Gearing M, Lippa CF, Montine TJ, Levey AI, Lah JJ. 2006. LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease. J Neuropathol Exp Neurol 65:866–872.
-
(2006)
J Neuropathol Exp Neurol
, vol.65
, pp. 866-872
-
-
Dodson, S.E.1
Gearing, M.2
Lippa, C.F.3
Montine, T.J.4
Levey, A.I.5
Lah, J.J.6
-
43
-
-
0025367968
-
Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat
-
Doyle E, Bruce MT, Breen KC, Smith DC, Anderton B, Regan CM. 1990. Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat. Neurosci Lett 115:97–102.
-
(1990)
Neurosci Lett
, vol.115
, pp. 97-102
-
-
Doyle, E.1
Bruce, M.T.2
Breen, K.C.3
Smith, D.C.4
Anderton, B.5
Regan, C.M.6
-
44
-
-
0026034352
-
NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway
-
East SJ, Garthwaite J. 1991. NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci Lett 123:17–19.
-
(1991)
Neurosci Lett
, vol.123
, pp. 17-19
-
-
East, S.J.1
Garthwaite, J.2
-
45
-
-
77949595824
-
Upregulation of the alpha-secretase ADAM10—risk or reason for hope?
-
Endres K, Fahrenholz F. 2010. Upregulation of the alpha-secretase ADAM10—risk or reason for hope? FEBS J 277:1585–1596.
-
(2010)
FEBS J
, vol.277
, pp. 1585-1596
-
-
Endres, K.1
Fahrenholz, F.2
-
46
-
-
84862850617
-
Regulation of alpha-secretase ADAM10 expression and activity
-
Endres K, Fahrenholz F. 2012. Regulation of alpha-secretase ADAM10 expression and activity. Exp Brain Res 217:343–352.
-
(2012)
Exp Brain Res
, vol.217
, pp. 343-352
-
-
Endres, K.1
Fahrenholz, F.2
-
47
-
-
33750156019
-
Alpha-secretase activation—an approach to Alzheimer's disease therapy
-
Fahrenholz F, Postina R. 2006. Alpha-secretase activation—an approach to Alzheimer's disease therapy. Neurodegen Dis 3:255–261.
-
(2006)
Neurodegen Dis
, vol.3
, pp. 255-261
-
-
Fahrenholz, F.1
Postina, R.2
-
48
-
-
0030823158
-
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
-
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM. 1997. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278:1349–1356.
-
(1997)
JAMA
, vol.278
, pp. 1349-1356
-
-
Farrer, L.A.1
Cupples, L.A.2
Haines, J.L.3
Hyman, B.4
Kukull, W.A.5
Mayeux, R.6
Myers, R.H.7
Pericak-Vance, M.A.8
Risch, N.9
van Duijn, C.M.10
-
49
-
-
0027400856
-
Changes in protein synthesis accompanying long-term potentiation in the dentate gyrus in vivo
-
Fazeli MS, Corbet J, Dunn MJ, Dolphin AC, Bliss TV. 1993. Changes in protein synthesis accompanying long-term potentiation in the dentate gyrus in vivo. J Neurosci 13:1346–1353.
-
(1993)
J Neurosci
, vol.13
, pp. 1346-1353
-
-
Fazeli, M.S.1
Corbet, J.2
Dunn, M.J.3
Dolphin, A.C.4
Bliss, T.V.5
-
50
-
-
84954377011
-
Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model
-
Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Muller UC. 2016. Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model. Acta Neuropathol 131:247–266.
-
(2016)
Acta Neuropathol
, vol.131
, pp. 247-266
-
-
Fol, R.1
Braudeau, J.2
Ludewig, S.3
Abel, T.4
Weyer, S.W.5
Roederer, J.P.6
Brod, F.7
Audrain, M.8
Bemelmans, A.P.9
Buchholz, C.J.10
Korte, M.11
Cartier, N.12
Muller, U.C.13
-
52
-
-
79959910328
-
Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells
-
Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. 2011. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem 286:24264–24274.
-
(2011)
J Biol Chem
, vol.286
, pp. 24264-24274
-
-
Freude, K.K.1
Penjwini, M.2
Davis, J.L.3
LaFerla, F.M.4
Blurton-Jones, M.5
-
53
-
-
0031905682
-
Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP
-
Furukawa K, Mattson MP. 1998. Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP. Neuroscience 83:429–438.
-
(1998)
Neuroscience
, vol.83
, pp. 429-438
-
-
Furukawa, K.1
Mattson, M.P.2
-
54
-
-
0030068094
-
+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein
-
+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature 379:74–78.
-
(1996)
Nature
, vol.379
, pp. 74-78
-
-
Furukawa, K.1
Barger, S.W.2
Blalock, E.M.3
Mattson, M.P.4
-
55
-
-
0029841562
-
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain
-
Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M, Mattson MP. 1996b. Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem 67:1882–1896.
-
(1996)
J Neurochem
, vol.67
, pp. 1882-1896
-
-
Furukawa, K.1
Sopher, B.L.2
Rydel, R.E.3
Begley, J.G.4
Pham, D.G.5
Martin, G.M.6
Fox, M.7
Mattson, M.P.8
-
56
-
-
50449084262
-
Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway
-
Gakhar-Koppole N, Hundeshagen P, Mandl C, Weyer SW, Allinquant B, Muller U, Ciccolini F. 2008. Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. Eur J Neurosci 28:871–882.
-
(2008)
Eur J Neurosci
, vol.28
, pp. 871-882
-
-
Gakhar-Koppole, N.1
Hundeshagen, P.2
Mandl, C.3
Weyer, S.W.4
Allinquant, B.5
Muller, U.6
Ciccolini, F.7
-
57
-
-
0024431373
-
Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization
-
Ghiso J, Tagliavini F, Timmers WF, Frangione B. 1989. Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization. Biochem Biophys Res Commun 163:430–437.
-
(1989)
Biochem Biophys Res Commun
, vol.163
, pp. 430-437
-
-
Ghiso, J.1
Tagliavini, F.2
Timmers, W.F.3
Frangione, B.4
-
59
-
-
0028169905
-
Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury
-
Goodman Y, Mattson MP. 1994. Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol 128:1–12.
-
(1994)
Exp Neurol
, vol.128
, pp. 1-12
-
-
Goodman, Y.1
Mattson, M.P.2
-
60
-
-
0036674604
-
The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system
-
Goto JJ, Tanzi RE. 2002. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. J Mol Neurosci 19:37–41.
-
(2002)
J Mol Neurosci
, vol.19
, pp. 37-41
-
-
Goto, J.J.1
Tanzi, R.E.2
-
61
-
-
33344458873
-
Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein
-
Gralle M, Oliveira CL, Guerreiro LH, McKinstry WJ, Galatis D, Masters CL, Cappai R, Parker MW, Ramos CH, Torriani I, Ferreira ST. 2006. Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein. J Mol Biol 357:493–508.
-
(2006)
J Mol Biol
, vol.357
, pp. 493-508
-
-
Gralle, M.1
Oliveira, C.L.2
Guerreiro, L.H.3
McKinstry, W.J.4
Galatis, D.5
Masters, C.L.6
Cappai, R.7
Parker, M.W.8
Ramos, C.H.9
Torriani, I.10
Ferreira, S.T.11
-
62
-
-
67649366042
-
Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers
-
Gralle M, Botelho MG, Wouters FS. 2009. Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem 284:15016–15025.
-
(2009)
J Biol Chem
, vol.284
, pp. 15016-15025
-
-
Gralle, M.1
Botelho, M.G.2
Wouters, F.S.3
-
63
-
-
0028980795
-
Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase
-
Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. 1995. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett 198:52–56.
-
(1995)
Neurosci Lett
, vol.198
, pp. 52-56
-
-
Greenberg, S.M.1
Qiu, W.Q.2
Selkoe, D.J.3
Ben-Itzhak, A.4
Kosik, K.S.5
-
64
-
-
0032524319
-
Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis
-
Guo Q, Robinson N, Mattson MP. 1998. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. J Biol Chem 273:12341–12351.
-
(1998)
J Biol Chem
, vol.273
, pp. 12341-12351
-
-
Guo, Q.1
Robinson, N.2
Mattson, M.P.3
-
65
-
-
84862953172
-
Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives
-
Guo Q, Li H, Gaddam SS, Justice NJ, Robertson CS, Zheng H. 2012a. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem 287:2437–2445.
-
(2012)
J Biol Chem
, vol.287
, pp. 2437-2445
-
-
Guo, Q.1
Li, H.2
Gaddam, S.S.3
Justice, N.J.4
Robertson, C.S.5
Zheng, H.6
-
66
-
-
84855483701
-
APP physiological and pathophysiological functions: insights from animal models
-
Guo Q, Wang Z, Li H, Wiese M, Zheng H. 2012b. APP physiological and pathophysiological functions: insights from animal models. Cell Res 22:78–89.
-
(2012)
Cell Res
, vol.22
, pp. 78-89
-
-
Guo, Q.1
Wang, Z.2
Li, H.3
Wiese, M.4
Zheng, H.5
-
67
-
-
84871815475
-
Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein
-
Gustafsen C, Glerup S, Pallesen LT, Olsen D, Andersen OM, Nykjaer A, Madsen P, Petersen CM. 2013. Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J Neurosci 33:64–71.
-
(2013)
J Neurosci
, vol.33
, pp. 64-71
-
-
Gustafsen, C.1
Glerup, S.2
Pallesen, L.T.3
Olsen, D.4
Andersen, O.M.5
Nykjaer, A.6
Madsen, P.7
Petersen, C.M.8
-
68
-
-
0027333557
-
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
-
Haass C, Selkoe DJ. 1993. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75:1039–1042.
-
(1993)
Cell
, vol.75
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.J.2
-
69
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D. 1991. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12:383–388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
70
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
-
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schurmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frolich L, Hampel H, Hull M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Muhleisen TW, Nothen MM, Moebus S, Jockel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J. 2009. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 41:1088–1093.
-
(2009)
Nat Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
Sims, R.4
Gerrish, A.5
Hamshere, M.L.6
Pahwa, J.S.7
Moskvina, V.8
Dowzell, K.9
Williams, A.10
Jones, N.11
Thomas, C.12
Stretton, A.13
Morgan, A.R.14
Lovestone, S.15
Powell, J.16
Proitsi, P.17
Lupton, M.K.18
Brayne, C.19
Rubinsztein, D.C.20
Gill, M.21
Lawlor, B.22
Lynch, A.23
Morgan, K.24
Brown, K.S.25
Passmore, P.A.26
Craig, D.27
McGuinness, B.28
Todd, S.29
Holmes, C.30
Mann, D.31
Smith, A.D.32
Love, S.33
Kehoe, P.G.34
Hardy, J.35
Mead, S.36
Fox, N.37
Rossor, M.38
Collinge, J.39
Maier, W.40
Jessen, F.41
Schurmann, B.42
Heun, R.43
van den Bussche, H.44
Heuser, I.45
Kornhuber, J.46
Wiltfang, J.47
Dichgans, M.48
Frolich, L.49
Hampel, H.50
Hull, M.51
Rujescu, D.52
Goate, A.M.53
Kauwe, J.S.54
Cruchaga, C.55
Nowotny, P.56
Morris, J.C.57
Mayo, K.58
Sleegers, K.59
Bettens, K.60
Engelborghs, S.61
De Deyn, P.P.62
Van Broeckhoven, C.63
Livingston, G.64
Bass, N.J.65
Gurling, H.66
McQuillin, A.67
Gwilliam, R.68
Deloukas, P.69
Al-Chalabi, A.70
Shaw, C.E.71
Tsolaki, M.72
Singleton, A.B.73
Guerreiro, R.74
Muhleisen, T.W.75
Nothen, M.M.76
Moebus, S.77
Jockel, K.H.78
Klopp, N.79
Wichmann, H.E.80
Carrasquillo, M.M.81
Pankratz, V.S.82
Younkin, S.G.83
Holmans, P.A.84
O'Donovan, M.85
Owen, M.J.86
Williams, J.87
more..
-
71
-
-
84878922963
-
Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons
-
Hartl D, Klatt S, Roch M, Konthur Z, Klose J, Willnow TE, Rohe M. 2013. Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons. PloS One 8:e65920.
-
(2013)
PloS One
, vol.8
-
-
Hartl, D.1
Klatt, S.2
Roch, M.3
Konthur, Z.4
Klose, J.5
Willnow, T.E.6
Rohe, M.7
-
72
-
-
84892752054
-
Soluble beta-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth
-
Hasebe N, Fujita Y, Ueno M, Yoshimura K, Fujino Y, Yamashita T. 2013. Soluble beta-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PloS One 8:e82321.
-
(2013)
PloS One
, vol.8
-
-
Hasebe, N.1
Fujita, Y.2
Ueno, M.3
Yoshimura, K.4
Fujino, Y.5
Yamashita, T.6
-
73
-
-
0027971320
-
Alzheimer amyloid protein precursor enhances proliferation of neural stem cells from fetal rat brain
-
Hayashi Y, Kashiwagi K, Ohta J, Nakajima M, Kawashima T, Yoshikawa K. 1994. Alzheimer amyloid protein precursor enhances proliferation of neural stem cells from fetal rat brain. Biochem Biophys Res Commun 205:936–943.
-
(1994)
Biochem Biophys Res Commun
, vol.205
, pp. 936-943
-
-
Hayashi, Y.1
Kashiwagi, K.2
Ohta, J.3
Nakajima, M.4
Kawashima, T.5
Yoshikawa, K.6
-
74
-
-
84930378369
-
Acute function of secreted amyloid precursor protein fragment APPsalpha in synaptic plasticity
-
Hick M, Herrmann U, Weyer SW, Mallm JP, Tschape JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Muller UC. 2015. Acute function of secreted amyloid precursor protein fragment APPsalpha in synaptic plasticity. Acta Neuropathol 129:21–37.
-
(2015)
Acta Neuropathol
, vol.129
, pp. 21-37
-
-
Hick, M.1
Herrmann, U.2
Weyer, S.W.3
Mallm, J.P.4
Tschape, J.A.5
Borgers, M.6
Mercken, M.7
Roth, F.C.8
Draguhn, A.9
Slomianka, L.10
Wolfer, D.P.11
Korte, M.12
Muller, U.C.13
-
75
-
-
0031891929
-
Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression—inverse correlation with dementia severity
-
Hock C, Golombowski S, Muller-Spahn F, Naser W, Beyreuther K, Monning U, Schenk D, Vigo-Pelfrey C, Bush AM, Moir R, Tanzi RE, Growdon JH, Nitsch RM. 1998. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression—inverse correlation with dementia severity. Eur Neurol 39:111–118.
-
(1998)
Eur Neurol
, vol.39
, pp. 111-118
-
-
Hock, C.1
Golombowski, S.2
Muller-Spahn, F.3
Naser, W.4
Beyreuther, K.5
Monning, U.6
Schenk, D.7
Vigo-Pelfrey, C.8
Bush, A.M.9
Moir, R.10
Tanzi, R.E.11
Growdon, J.H.12
Nitsch, R.M.13
-
76
-
-
84902096534
-
Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain
-
Hoefgen S, Coburger I, Roeser D, Schaub Y, Dahms SO, Than ME. 2014. Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain. J Struct Biol 187:30–37.
-
(2014)
J Struct Biol
, vol.187
, pp. 30-37
-
-
Hoefgen, S.1
Coburger, I.2
Roeser, D.3
Schaub, Y.4
Dahms, S.O.5
Than, M.E.6
-
77
-
-
0032992044
-
Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces
-
Hoffmann J, Pietrzik CU, Kummer MP, Twiesselmann C, Bauer C, Herzog V. 1999. Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces. J Histochen Cytochem 47:373–382.
-
(1999)
J Histochen Cytochem
, vol.47
, pp. 373-382
-
-
Hoffmann, J.1
Pietrzik, C.U.2
Kummer, M.P.3
Twiesselmann, C.4
Bauer, C.5
Herzog, V.6
-
78
-
-
0032576963
-
Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease
-
Honda M, Akiyama H, Yamada Y, Kondo H, Kawabe Y, Takeya M, Takahashi K, Suzuki H, Doi T, Sakamoto A, Ookawara S, Mato M, Gough PJ, Greaves DR, Gordon S, Kodama T, Matsushita M. 1998. Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease. Biochem Biophys Res Commun 245:734–740.
-
(1998)
Biochem Biophys Res Commun
, vol.245
, pp. 734-740
-
-
Honda, M.1
Akiyama, H.2
Yamada, Y.3
Kondo, H.4
Kawabe, Y.5
Takeya, M.6
Takahashi, K.7
Suzuki, H.8
Doi, T.9
Sakamoto, A.10
Ookawara, S.11
Mato, M.12
Gough, P.J.13
Greaves, D.R.14
Gordon, S.15
Kodama, T.16
Matsushita, M.17
-
79
-
-
85031652979
-
sAPP-alpha modulates gamma-secretase processing of APP
-
Hou H, Obregon D, Shahaduzzaman MD, Song M, Tian J, Giunta B, Mori T, Mattson M, Tan J. 2010. sAPP-alpha modulates gamma-secretase processing of APP. Alzheimers Dement 7:S402–S403.
-
(2010)
Alzheimers Dement
, vol.7
, pp. S402-S403
-
-
Hou, H.1
Obregon, D.2
Shahaduzzaman, M.D.3
Song, M.4
Tian, J.5
Giunta, B.6
Mori, T.7
Mattson, M.8
Tan, J.9
-
80
-
-
0032732224
-
Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors
-
Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L. 1999. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol 155:1741–1747.
-
(1999)
Am J Pathol
, vol.155
, pp. 1741-1747
-
-
Huang, F.1
Buttini, M.2
Wyss-Coray, T.3
McConlogue, L.4
Kodama, T.5
Pitas, R.E.6
Mucke, L.7
-
81
-
-
0027409609
-
Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach
-
Huber G, Martin JR, Loffler J, Moreau JL. 1993. Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach. Brain Res 603:348–352.
-
(1993)
Brain Res
, vol.603
, pp. 348-352
-
-
Huber, G.1
Martin, J.R.2
Loffler, J.3
Moreau, J.L.4
-
82
-
-
0030763739
-
Synaptic beta-amyloid precursor proteins increase with learning capacity in rats
-
Huber G, Bailly Y, Martin JR, Mariani J, Brugg B. 1997. Synaptic beta-amyloid precursor proteins increase with learning capacity in rats. Neuroscience 80:313–320.
-
(1997)
Neuroscience
, vol.80
, pp. 313-320
-
-
Huber, G.1
Bailly, Y.2
Martin, J.R.3
Mariani, J.4
Brugg, B.5
-
83
-
-
0030797332
-
Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices
-
Ishida A, Furukawa K, Keller JN, Mattson MP. 1997. Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices. Neuroreport 8:2133–2137.
-
(1997)
Neuroreport
, vol.8
, pp. 2133-2137
-
-
Ishida, A.1
Furukawa, K.2
Keller, J.N.3
Mattson, M.P.4
-
84
-
-
84873715194
-
Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder
-
Jakobsson J, Zetterberg H, Blennow K, Johan Ekman C, Johansson AG, Landen M. 2013. Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder. Neuropsychopharmacology 38:664–672.
-
(2013)
Neuropsychopharmacology
, vol.38
, pp. 664-672
-
-
Jakobsson, J.1
Zetterberg, H.2
Blennow, K.3
Johan Ekman, C.4
Johansson, A.G.5
Landen, M.6
-
85
-
-
79961012890
-
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo
-
Jefferson T, Causevic M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. 2011. Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. J Biol Chem 286:27741–27750.
-
(2011)
J Biol Chem
, vol.286
, pp. 27741-27750
-
-
Jefferson, T.1
Causevic, M.2
auf dem Keller, U.3
Schilling, O.4
Isbert, S.5
Geyer, R.6
Maier, W.7
Tschickardt, S.8
Jumpertz, T.9
Weggen, S.10
Bond, J.S.11
Overall, C.M.12
Pietrzik, C.U.13
Becker-Pauly, C.14
-
86
-
-
79956320988
-
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model
-
Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J. 2011. Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. J Biol Chem 286:18414–18425.
-
(2011)
J Biol Chem
, vol.286
, pp. 18414-18425
-
-
Jimenez, S.1
Torres, M.2
Vizuete, M.3
Sanchez-Varo, R.4
Sanchez-Mejias, E.5
Trujillo-Estrada, L.6
Carmona-Cuenca, I.7
Caballero, C.8
Ruano, D.9
Gutierrez, A.10
Vitorica, J.11
-
87
-
-
0028136865
-
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension
-
Jin LW, Ninomiya H, Roch JM, Schubert D, Masliah E, Otero DA, Saitoh T. 1994. Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J Neurosci 14:5461–5470.
-
(1994)
J Neurosci
, vol.14
, pp. 5461-5470
-
-
Jin, L.W.1
Ninomiya, H.2
Roch, J.M.3
Schubert, D.4
Masliah, E.5
Otero, D.A.6
Saitoh, T.7
-
88
-
-
84862837302
-
Role of APP for dendritic spine formation and stability
-
Jung CK, Herms J. 2012. Role of APP for dendritic spine formation and stability. Exp Brain Res 217:463–470.
-
(2012)
Exp Brain Res
, vol.217
, pp. 463-470
-
-
Jung, C.K.1
Herms, J.2
-
89
-
-
43749112022
-
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP
-
Kaden D, Munter LM, Joshi M, Treiber C, Weise C, Bethge T, Voigt P, Schaefer M, Beyermann M, Reif B, Multhaup G. 2008. Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. J Biol Chem 283:7271–7279.
-
(2008)
J Biol Chem
, vol.283
, pp. 7271-7279
-
-
Kaden, D.1
Munter, L.M.2
Joshi, M.3
Treiber, C.4
Weise, C.5
Bethge, T.6
Voigt, P.7
Schaefer, M.8
Beyermann, M.9
Reif, B.10
Multhaup, G.11
-
90
-
-
84901341240
-
The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease
-
Kanekiyo T, Bu G. 2014. The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease. Front Aging Neurosci 6:93.
-
(2014)
Front Aging Neurosci
, vol.6
, pp. 93
-
-
Kanekiyo, T.1
Bu, G.2
-
91
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733–736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
92
-
-
77953582321
-
What is the role of amyloid precursor protein dimerization?
-
Khalifa NB, Van Hees J, Tasiaux B, Huysseune S, Smith SO, Constantinescu SN, Octave JN, Kienlen-Campard P. 2010. What is the role of amyloid precursor protein dimerization? Cell Adhes Migrat 4:268–272.
-
(2010)
Cell Adhes Migrat
, vol.4
, pp. 268-272
-
-
Khalifa, N.B.1
Van Hees, J.2
Tasiaux, B.3
Huysseune, S.4
Smith, S.O.5
Constantinescu, S.N.6
Octave, J.N.7
Kienlen-Campard, P.8
-
93
-
-
70349569016
-
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
-
Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. 2009. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet 18:3987–3996.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3987-3996
-
-
Kim, M.1
Suh, J.2
Romano, D.3
Truong, M.H.4
Mullin, K.5
Hooli, B.6
Norton, D.7
Tesco, G.8
Elliott, K.9
Wagner, S.L.10
Moir, R.D.11
Becker, K.D.12
Tanzi, R.E.13
-
94
-
-
0030592750
-
Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)
-
Knauer MF, Orlando RA, Glabe CG. 1996. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). Brain Res 740:6–14.
-
(1996)
Brain Res
, vol.740
, pp. 6-14
-
-
Knauer, M.F.1
Orlando, R.A.2
Glabe, C.G.3
-
95
-
-
69449094771
-
The p75 neurotrophin receptor promotes amyloid-beta(1–42)-induced neuritic dystrophy in vitro and in vivo
-
Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. 2009. The p75 neurotrophin receptor promotes amyloid-beta(1–42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci 29:10627–10637.
-
(2009)
J Neurosci
, vol.29
, pp. 10627-10637
-
-
Knowles, J.K.1
Rajadas, J.2
Nguyen, T.V.3
Yang, T.4
LeMieux, M.C.5
Vander Griend, L.6
Ishikawa, C.7
Massa, S.M.8
Wyss-Coray, T.9
Longo, F.M.10
-
96
-
-
11844251260
-
Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway
-
Kogel D, Schomburg R, Copanaki E, Prehn JH. 2005. Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. Cell Death Differ 12:1–9.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1-9
-
-
Kogel, D.1
Schomburg, R.2
Copanaki, E.3
Prehn, J.H.4
-
97
-
-
0029128232
-
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation
-
Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. 1995. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 82:331–340.
-
(1995)
Cell
, vol.82
, pp. 331-340
-
-
Kounnas, M.Z.1
Moir, R.D.2
Rebeck, G.W.3
Bush, A.I.4
Argraves, W.S.5
Tanzi, R.E.6
Hyman, B.T.7
Strickland, D.K.8
-
98
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fievet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossu P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanche H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alperovitch A, Lathrop M, Amouyel P. 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41:1094–1099.
-
(2009)
Nat Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
Campion, D.4
Sleegers, K.5
Hiltunen, M.6
Combarros, O.7
Zelenika, D.8
Bullido, M.J.9
Tavernier, B.10
Letenneur, L.11
Bettens, K.12
Berr, C.13
Pasquier, F.14
Fievet, N.15
Barberger-Gateau, P.16
Engelborghs, S.17
De Deyn, P.18
Mateo, I.19
Franck, A.20
Helisalmi, S.21
Porcellini, E.22
Hanon, O.23
de Pancorbo, M.M.24
Lendon, C.25
Dufouil, C.26
Jaillard, C.27
Leveillard, T.28
Alvarez, V.29
Bosco, P.30
Mancuso, M.31
Panza, F.32
Nacmias, B.33
Bossu, P.34
Piccardi, P.35
Annoni, G.36
Seripa, D.37
Galimberti, D.38
Hannequin, D.39
Licastro, F.40
Soininen, H.41
Ritchie, K.42
Blanche, H.43
Dartigues, J.F.44
Tzourio, C.45
Gut, I.46
Van Broeckhoven, C.47
Alperovitch, A.48
Lathrop, M.49
Amouyel, P.50
more..
-
99
-
-
0028982840
-
Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease
-
Lannfelt L, Basun H, Wahlund LO, Rowe BA, Wagner SL. 1995. Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease. Nat Med 1:829–832.
-
(1995)
Nat Med
, vol.1
, pp. 829-832
-
-
Lannfelt, L.1
Basun, H.2
Wahlund, L.O.3
Rowe, B.A.4
Wagner, S.L.5
-
100
-
-
75549090428
-
Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study
-
Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Burger K, Hampel H, Frolich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hull M, Schroder J, Kessler H, Pantel J, Gertz HJ, Klafki HW, Kolsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J. 2010. Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry 15:138–145.
-
(2010)
Mol Psychiatry
, vol.15
, pp. 138-145
-
-
Lewczuk, P.1
Kamrowski-Kruck, H.2
Peters, O.3
Heuser, I.4
Jessen, F.5
Popp, J.6
Burger, K.7
Hampel, H.8
Frolich, L.9
Wolf, S.10
Prinz, B.11
Jahn, H.12
Luckhaus, C.13
Perneczky, R.14
Hull, M.15
Schroder, J.16
Kessler, H.17
Pantel, J.18
Gertz, H.J.19
Klafki, H.W.20
Kolsch, H.21
Reulbach, U.22
Esselmann, H.23
Maler, J.M.24
Bibl, M.25
Kornhuber, J.26
Wiltfang, J.27
more..
-
101
-
-
0030951506
-
Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease
-
Li HL, Roch JM, Sundsmo M, Otero D, Sisodia S, Thomas R, Saitoh T. 1997. Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease. J Neurobiol 32:469–480.
-
(1997)
J Neurobiol
, vol.32
, pp. 469-480
-
-
Li, H.L.1
Roch, J.M.2
Sundsmo, M.3
Otero, D.4
Sisodia, S.5
Thomas, R.6
Saitoh, T.7
-
102
-
-
78049267204
-
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
-
Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Sudhof TC, Zheng H. 2010. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A 107:17362–17367.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 17362-17367
-
-
Li, H.1
Wang, B.2
Wang, Z.3
Guo, Q.4
Tabuchi, K.5
Hammer, R.E.6
Sudhof, T.C.7
Zheng, H.8
-
103
-
-
84873722367
-
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
-
Liu CC, Kanekiyo T, Xu H, Bu G. 2013. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 9:106–118.
-
(2013)
Nat Rev Neurol
, vol.9
, pp. 106-118
-
-
Liu, C.C.1
Kanekiyo, T.2
Xu, H.3
Bu, G.4
-
104
-
-
0027478347
-
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein
-
Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10:243–254.
-
(1993)
Neuron
, vol.10
, pp. 243-254
-
-
Mattson, M.P.1
Cheng, B.2
Culwell, A.R.3
Esch, F.S.4
Lieberburg, I.5
Rydel, R.E.6
-
105
-
-
0030611750
-
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
-
Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K. 1997. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681–697.
-
(1997)
J Neurosci Res
, vol.49
, pp. 681-697
-
-
Mattson, M.P.1
Goodman, Y.2
Luo, H.3
Fu, W.4
Furukawa, K.5
-
106
-
-
0030048606
-
Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction
-
Maurice T, Lockhart BP, Privat A. 1996. Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 706:181–193.
-
(1996)
Brain Res
, vol.706
, pp. 181-193
-
-
Maurice, T.1
Lockhart, B.P.2
Privat, A.3
-
107
-
-
0032514633
-
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice
-
Meziane H, Dodart JC, Mathis C, Little S, Clemens J, Paul SM, Ungerer A. 1998. Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice. Proc Natl Acad Sci U S A 95:12683–12688.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 12683-12688
-
-
Meziane, H.1
Dodart, J.C.2
Mathis, C.3
Little, S.4
Clemens, J.5
Paul, S.M.6
Ungerer, A.7
-
109
-
-
84906850064
-
Holo-APP and G-protein-mediated signaling are required for sAPP[alpha]-induced activation of the Akt survival pathway
-
Milosch N, Tanriover G, Kundu A, Rami A, Francois JC, Baumkotter F, Weyer SW, Samanta A, Jaschke A, Brod F, Buchholz CJ, Kins S, Behl C, Muller UC, Kogel D. 2014. Holo-APP and G-protein-mediated signaling are required for sAPP[alpha]-induced activation of the Akt survival pathway. Cell Death Dis 5:e1391.
-
(2014)
Cell Death Dis
, vol.5
-
-
Milosch, N.1
Tanriover, G.2
Kundu, A.3
Rami, A.4
Francois, J.C.5
Baumkotter, F.6
Weyer, S.W.7
Samanta, A.8
Jaschke, A.9
Brod, F.10
Buchholz, C.J.11
Kins, S.12
Behl, C.13
Muller, U.C.14
Kogel, D.15
-
110
-
-
0026663993
-
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth
-
Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther K, Masters CL. 1992. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9:129–137.
-
(1992)
Neuron
, vol.9
, pp. 129-137
-
-
Milward, E.A.1
Papadopoulos, R.2
Fuller, S.J.3
Moir, R.D.4
Small, D.5
Beyreuther, K.6
Masters, C.L.7
-
111
-
-
84872407604
-
Soluble amyloid precursor protein alpha in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus
-
Miyajima M, Nakajima M, Ogino I, Miyata H, Motoi Y, Arai H. 2013. Soluble amyloid precursor protein alpha in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus. Eur J Neurol 20:236–242.
-
(2013)
Eur J Neurol
, vol.20
, pp. 236-242
-
-
Miyajima, M.1
Nakajima, M.2
Ogino, I.3
Miyata, H.4
Motoi, Y.5
Arai, H.6
-
112
-
-
20844433715
-
LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP
-
Moir RD, Tanzi RE. 2005. LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP. Curr Alzheimer Res 2:269–273.
-
(2005)
Curr Alzheimer Res
, vol.2
, pp. 269-273
-
-
Moir, R.D.1
Tanzi, R.E.2
-
113
-
-
18844473445
-
Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease
-
Mok SS, Sberna G, Heffernan D, Cappai R, Galatis D, Clarris HJ, Sawyer WH, Beyreuther K, Masters CL, Small DH. 1997. Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease. FEBS Lett 415:303–307.
-
(1997)
FEBS Lett
, vol.415
, pp. 303-307
-
-
Mok, S.S.1
Sberna, G.2
Heffernan, D.3
Cappai, R.4
Galatis, D.5
Clarris, H.J.6
Sawyer, W.H.7
Beyreuther, K.8
Masters, C.L.9
Small, D.H.10
-
114
-
-
84946015384
-
sAbetaPPalpha improves hippocampal NMDA-dependent functional alterations linked to healthy aging
-
Moreno L, Rose C, Mohanraj A, Allinquant B, Billard JM, Dutar P. 2015. sAbetaPPalpha improves hippocampal NMDA-dependent functional alterations linked to healthy aging. J Alzheimers Dis 48:927–935.
-
(2015)
J Alzheimers Dis
, vol.48
, pp. 927-935
-
-
Moreno, L.1
Rose, C.2
Mohanraj, A.3
Allinquant, B.4
Billard, J.M.5
Dutar, P.6
-
116
-
-
0028018919
-
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene
-
Muller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rulicke T, Brandner S, Aguzzi A, Weissmann C. 1994. Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79:755–765.
-
(1994)
Cell
, vol.79
, pp. 755-765
-
-
Muller, U.1
Cristina, N.2
Li, Z.W.3
Wolfer, D.P.4
Lipp, H.P.5
Rulicke, T.6
Brandner, S.7
Aguzzi, A.8
Weissmann, C.9
-
117
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M. 2009. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981–989.
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O'Leary, D.D.3
Tessier-Lavigne, M.4
-
118
-
-
46749104502
-
Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice
-
Nikolic WV, Hou H, Town T, Zhu Y, Giunta B, Sanberg CD, Zeng J, Luo D, Ehrhart J, Mori T, Sanberg PR, Tan J. 2008. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev 17:423–439.
-
(2008)
Stem Cells Dev
, vol.17
, pp. 423-439
-
-
Nikolic, W.V.1
Hou, H.2
Town, T.3
Zhu, Y.4
Giunta, B.5
Sanberg, C.D.6
Zeng, J.7
Luo, D.8
Ehrhart, J.9
Mori, T.10
Sanberg, P.R.11
Tan, J.12
-
119
-
-
0027221517
-
Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth
-
Ninomiya H, Roch JM, Sundsmo MP, Otero DA, Saitoh T. 1993. Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth. J Cell Biol 121:879–886.
-
(1993)
J Cell Biol
, vol.121
, pp. 879-886
-
-
Ninomiya, H.1
Roch, J.M.2
Sundsmo, M.P.3
Otero, D.A.4
Saitoh, T.5
-
120
-
-
84860299843
-
Soluble amyloid precursor protein-alpha modulates beta-secretase activity and amyloid-beta generation
-
Obregon D, Hou H, Deng J, Giunta B, Tian J, Darlington D, Shahaduzzaman M, Zhu Y, Mori T, Mattson MP, Tan J. 2012. Soluble amyloid precursor protein-alpha modulates beta-secretase activity and amyloid-beta generation. Nat Commun 3:777.
-
(2012)
Nat Commun
, vol.3
, pp. 777
-
-
Obregon, D.1
Hou, H.2
Deng, J.3
Giunta, B.4
Tian, J.5
Darlington, D.6
Shahaduzzaman, M.7
Zhu, Y.8
Mori, T.9
Mattson, M.P.10
Tan, J.11
-
121
-
-
0033012984
-
Amino–terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells
-
Ohsawa I, Takamura C, Morimoto T, Ishiguro M, Kohsaka S. 1999. Amino–terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur J Neurosci 11:1907–1913.
-
(1999)
Eur J Neurosci
, vol.11
, pp. 1907-1913
-
-
Ohsawa, I.1
Takamura, C.2
Morimoto, T.3
Ishiguro, M.4
Kohsaka, S.5
-
122
-
-
0035096910
-
Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function
-
Ohsawa I, Takamura C, Kohsaka S. 2001. Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function. J Neurochem 76:1411–1420.
-
(2001)
J Neurochem
, vol.76
, pp. 1411-1420
-
-
Ohsawa, I.1
Takamura, C.2
Kohsaka, S.3
-
123
-
-
0025302430
-
Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease
-
Palmert MR, Usiak M, Mayeux R, Raskind M, Tourtellotte WW, Younkin SG. 1990. Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Neurology 40:1028–1034.
-
(1990)
Neurology
, vol.40
, pp. 1028-1034
-
-
Palmert, M.R.1
Usiak, M.2
Mayeux, R.3
Raskind, M.4
Tourtellotte, W.W.5
Younkin, S.G.6
-
124
-
-
77954132249
-
Amyloid–beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
-
Palop JJ, Mucke L. 2010. Amyloid–beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci 13:812–818.
-
(2010)
Nat Neurosci
, vol.13
, pp. 812-818
-
-
Palop, J.J.1
Mucke, L.2
-
125
-
-
84937432830
-
Dysregulated ADAM10-mediated processing of APP during a critical time window leads to synaptic deficits in fragile X syndrome
-
Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Muller UC, Di Luca M, De Strooper B, Bagni C. 2015. Dysregulated ADAM10-mediated processing of APP during a critical time window leads to synaptic deficits in fragile X syndrome. Neuron 87:382–398.
-
(2015)
Neuron
, vol.87
, pp. 382-398
-
-
Pasciuto, E.1
Ahmed, T.2
Wahle, T.3
Gardoni, F.4
D'Andrea, L.5
Pacini, L.6
Jacquemont, S.7
Tassone, F.8
Balschun, D.9
Dotti, C.G.10
Callaerts-Vegh, Z.11
D'Hooge, R.12
Muller, U.C.13
Di Luca, M.14
De Strooper, B.15
Bagni, C.16
-
126
-
-
69249117009
-
ADAM9 as a potential target molecule in cancer
-
Peduto L. 2009. ADAM9 as a potential target molecule in cancer. Curr Pharm Des 15:2282–2287.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 2282-2287
-
-
Peduto, L.1
-
127
-
-
0031453752
-
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity
-
Perez RG, Zheng H, Van der Ploeg LH, Koo EH. 1997. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17:9407–9414.
-
(1997)
J Neurosci
, vol.17
, pp. 9407-9414
-
-
Perez, R.G.1
Zheng, H.2
Van der Ploeg, L.H.3
Koo, E.H.4
-
128
-
-
80051503650
-
CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease
-
Perneczky R, Tsolakidou A, Arnold A, Diehl-Schmid J, Grimmer T, Forstl H, Kurz A, Alexopoulos P. 2011. CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease. Neurology 77:35–38.
-
(2011)
Neurology
, vol.77
, pp. 35-38
-
-
Perneczky, R.1
Tsolakidou, A.2
Arnold, A.3
Diehl-Schmid, J.4
Grimmer, T.5
Forstl, H.6
Kurz, A.7
Alexopoulos, P.8
-
129
-
-
84873664575
-
Soluble amyloid precursor protein beta as blood-based biomarker of Alzheimer's disease
-
Perneczky R, Guo LH, Kagerbauer SM, Werle L, Kurz A, Martin J, Alexopoulos P. 2013. Soluble amyloid precursor protein beta as blood-based biomarker of Alzheimer's disease. Transl Psychiatry 3:e227.
-
(2013)
Transl Psychiatry
, vol.3
-
-
Perneczky, R.1
Guo, L.H.2
Kagerbauer, S.M.3
Werle, L.4
Kurz, A.5
Martin, J.6
Alexopoulos, P.7
-
130
-
-
84938691417
-
sAbetaPPalpha is a Potent Endogenous Inhibitor of BACE1
-
Peters-Libeu C, Campagna J, Mitsumori M, Poksay KS, Spilman P, Sabogal A, Bredesen DE, John V. 2015. sAbetaPPalpha is a Potent Endogenous Inhibitor of BACE1. J Alzheimers Dis 47:545–555.
-
(2015)
J Alzheimers Dis
, vol.47
, pp. 545-555
-
-
Peters-Libeu, C.1
Campagna, J.2
Mitsumori, M.3
Poksay, K.S.4
Spilman, P.5
Sabogal, A.6
Bredesen, D.E.7
John, V.8
-
131
-
-
0032539666
-
From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells
-
Pietrzik CU, Hoffmann J, Stober K, Chen CY, Bauer C, Otero DA, Roch JM, Herzog V. 1998. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc Natl Acad Sci U S A 95:1770–1775.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 1770-1775
-
-
Pietrzik, C.U.1
Hoffmann, J.2
Stober, K.3
Chen, C.Y.4
Bauer, C.5
Otero, D.A.6
Roch, J.M.7
Herzog, V.8
-
132
-
-
69949132002
-
Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells
-
Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS. 2009. Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. J Biol Chem 284:23806–23817.
-
(2009)
J Biol Chem
, vol.284
, pp. 23806-23817
-
-
Porayette, P.1
Gallego, M.J.2
Kaltcheva, M.M.3
Bowen, R.L.4
Vadakkadath Meethal, S.5
Atwood, C.S.6
-
133
-
-
0026059694
-
Quantitative changes in the amyloid beta A4 precursor protein in Alzheimer cerebrospinal fluid
-
Prior R, Monning U, Schreiter-Gasser U, Weidemann A, Blennow K, Gottfries CG, Masters CL, Beyreuther K. 1991. Quantitative changes in the amyloid beta A4 precursor protein in Alzheimer cerebrospinal fluid. Neurosci Lett 124:69–73.
-
(1991)
Neurosci Lett
, vol.124
, pp. 69-73
-
-
Prior, R.1
Monning, U.2
Schreiter-Gasser, U.3
Weidemann, A.4
Blennow, K.5
Gottfries, C.G.6
Masters, C.L.7
Beyreuther, K.8
-
134
-
-
0029257190
-
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
-
Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. 1995. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 15:2157–2167.
-
(1995)
J Neurosci
, vol.15
, pp. 2157-2167
-
-
Qiu, W.Q.1
Ferreira, A.2
Miller, C.3
Koo, E.H.4
Selkoe, D.J.5
-
135
-
-
79959407483
-
Increased secreted amyloid precursor protein-alpha (sAPPalpha) in severe autism: proposal of a specific, anabolic pathway and putative biomarker
-
Ray B, Long JM, Sokol DK, Lahiri DK. 2011. Increased secreted amyloid precursor protein-alpha (sAPPalpha) in severe autism: proposal of a specific, anabolic pathway and putative biomarker. PloS One 6:e20405.
-
(2011)
PloS One
, vol.6
-
-
Ray, B.1
Long, J.M.2
Sokol, D.K.3
Lahiri, D.K.4
-
136
-
-
84887574873
-
Soluble amyloid-beta precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans
-
Reinhard C, Borgers M, David G, De Strooper B. 2013. Soluble amyloid-beta precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans. J Cell Sci 126:4856–4861.
-
(2013)
J Cell Sci
, vol.126
, pp. 4856-4861
-
-
Reinhard, C.1
Borgers, M.2
David, G.3
De Strooper, B.4
-
137
-
-
34447640166
-
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
-
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC. 2007. The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27:7817–7826.
-
(2007)
J Neurosci
, vol.27
, pp. 7817-7826
-
-
Ring, S.1
Weyer, S.W.2
Kilian, S.B.3
Waldron, E.4
Pietrzik, C.U.5
Filippov, M.A.6
Herms, J.7
Buchholz, C.8
Eckman, C.B.9
Korte, M.10
Wolfer, D.P.11
Muller, U.C.12
-
138
-
-
0028071334
-
Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor
-
Roch JM, Masliah E, Roch-Levecq AC, Sundsmo MP, Otero DA, Veinbergs I, Saitoh T. 1994. Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc Natl Acad Sci U S A 91:7450–7454.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 7450-7454
-
-
Roch, J.M.1
Masliah, E.2
Roch-Levecq, A.C.3
Sundsmo, M.P.4
Otero, D.A.5
Veinbergs, I.6
Saitoh, T.7
-
139
-
-
33846613222
-
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song Y-Q, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St. George-Hyslop P. 2007. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39:168–177.
-
(2007)
Nat Genet
, vol.39
, pp. 168-177
-
-
Rogaeva, E.1
Meng, Y.2
Lee, J.H.3
Gu, Y.4
Kawarai, T.5
Zou, F.6
Katayama, T.7
Baldwin, C.T.8
Cheng, R.9
Hasegawa, H.10
Chen, F.11
Shibata, N.12
Lunetta, K.L.13
Pardossi-Piquard, R.14
Bohm, C.15
Wakutani, Y.16
Cupples, L.A.17
Cuenco, K.T.18
Green, R.C.19
Pinessi, L.20
Rainero, I.21
Sorbi, S.22
Bruni, A.23
Duara, R.24
Friedland, R.P.25
Inzelberg, R.26
Hampe, W.27
Bujo, H.28
Song, Y.-Q.29
Andersen, O.M.30
Willnow, T.E.31
Graff-Radford, N.32
Petersen, R.C.33
Dickson, D.34
Der, S.D.35
Fraser, P.E.36
Schmitt-Ulms, G.37
Younkin, S.38
Mayeux, R.39
Farrer, L.A.40
St George-Hyslop, P.41
more..
-
140
-
-
84857995781
-
Cerebrospinal fluid profiles of amyloid beta-related biomarkers in Alzheimer's disease
-
Rosen C, Andreasson U, Mattsson N, Marcusson J, Minthon L, Andreasen N, Blennow K, Zetterberg H. 2012. Cerebrospinal fluid profiles of amyloid beta-related biomarkers in Alzheimer's disease. Neuromol Med 14:65–73.
-
(2012)
Neuromol Med
, vol.14
, pp. 65-73
-
-
Rosen, C.1
Andreasson, U.2
Mattsson, N.3
Marcusson, J.4
Minthon, L.5
Andreasen, N.6
Blennow, K.7
Zetterberg, H.8
-
141
-
-
0032945805
-
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
-
Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. 1999. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6:327–331.
-
(1999)
Nat Struct Biol
, vol.6
, pp. 327-331
-
-
Rossjohn, J.1
Cappai, R.2
Feil, S.C.3
Henry, A.4
McKinstry, W.J.5
Galatis, D.6
Hesse, L.7
Multhaup, G.8
Beyreuther, K.9
Masters, C.L.10
Parker, M.W.11
-
142
-
-
79955470772
-
The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: novel drug targets with therapeutic potential?
-
Saftig P, Reiss K. 2011. The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: novel drug targets with therapeutic potential? Eur J Cell Biol 90:527–535.
-
(2011)
Eur J Cell Biol
, vol.90
, pp. 527-535
-
-
Saftig, P.1
Reiss, K.2
-
143
-
-
0024395366
-
Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts
-
Saitoh T, Sundsmo M, Roch JM, Kimura N, Cole G, Schubert D, Oltersdorf T, Schenk DB. 1989. Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell 58:615–622.
-
(1989)
Cell
, vol.58
, pp. 615-622
-
-
Saitoh, T.1
Sundsmo, M.2
Roch, J.M.3
Kimura, N.4
Cole, G.5
Schubert, D.6
Oltersdorf, T.7
Schenk, D.B.8
-
144
-
-
0028445312
-
Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons
-
Salbaum JM, Ruddle FH. 1994. Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons. J Exp Zool 269:116–127.
-
(1994)
J Exp Zool
, vol.269
, pp. 116-127
-
-
Salbaum, J.M.1
Ruddle, F.H.2
-
145
-
-
0035903204
-
Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor
-
Santiago-Garcia J, Mas-Oliva J, Innerarity TL, Pitas RE. 2001. Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor. J Biol Chem 276:30655–30661.
-
(2001)
J Biol Chem
, vol.276
, pp. 30655-30661
-
-
Santiago-Garcia, J.1
Mas-Oliva, J.2
Innerarity, T.L.3
Pitas, R.E.4
-
146
-
-
0035823495
-
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
-
Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA, Beyreuther K, Multhaup G. 2001. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem 276:33923–33929.
-
(2001)
J Biol Chem
, vol.276
, pp. 33923-33929
-
-
Scheuermann, S.1
Hambsch, B.2
Hesse, L.3
Stumm, J.4
Schmidt, C.5
Beher, D.6
Bayer, T.A.7
Beyreuther, K.8
Multhaup, G.9
-
147
-
-
84958974231
-
Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site
-
Schonherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU. 2016. Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site. Mol Neurodegen 11:19.
-
(2016)
Mol Neurodegen
, vol.11
, pp. 19
-
-
Schonherr, C.1
Bien, J.2
Isbert, S.3
Wichert, R.4
Prox, J.5
Altmeppen, H.6
Kumar, S.7
Walter, J.8
Lichtenthaler, S.F.9
Weggen, S.10
Glatzel, M.11
Becker-Pauly, C.12
Pietrzik, C.U.13
-
148
-
-
0033012737
-
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein
-
Seabrook GR, Smith DW, Bowery BJ, Easter A, Reynolds T, Fitzjohn SM, Morton RA, Zheng H, Dawson GR, Sirinathsinghji DJ, Davies CH, Collingridge GL, Hill RG. 1999. Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology 38:349–359.
-
(1999)
Neuropharmacology
, vol.38
, pp. 349-359
-
-
Seabrook, G.R.1
Smith, D.W.2
Bowery, B.J.3
Easter, A.4
Reynolds, T.5
Fitzjohn, S.M.6
Morton, R.A.7
Zheng, H.8
Dawson, G.R.9
Sirinathsinghji, D.J.10
Davies, C.H.11
Collingridge, G.L.12
Hill, R.G.13
-
149
-
-
77955075644
-
Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
-
Selnes P, Blennow K, Zetterberg H, Grambaite R, Rosengren L, Johnsen L, Stenset V, Fladby T. 2010. Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid. Cerebrospinal Fluid Res 7:10.
-
(2010)
Cerebrospinal Fluid Res
, vol.7
, pp. 10
-
-
Selnes, P.1
Blennow, K.2
Zetterberg, H.3
Grambaite, R.4
Rosengren, L.5
Johnsen, L.6
Stenset, V.7
Fladby, T.8
-
150
-
-
0033987298
-
Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients
-
Sennvik K, Fastbom J, Blomberg M, Wahlund LO, Winblad B, Benedikz E. 2000. Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett 278:169–172.
-
(2000)
Neurosci Lett
, vol.278
, pp. 169-172
-
-
Sennvik, K.1
Fastbom, J.2
Blomberg, M.3
Wahlund, L.O.4
Winblad, B.5
Benedikz, E.6
-
151
-
-
0028213567
-
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
-
Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL. 1994. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci 14:2117–2127.
-
(1994)
J Neurosci
, vol.14
, pp. 2117-2127
-
-
Small, D.H.1
Nurcombe, V.2
Reed, G.3
Clarris, H.4
Moir, R.5
Beyreuther, K.6
Masters, C.L.7
-
152
-
-
0033301776
-
Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease
-
Small DH, Clarris HL, Williamson TG, Reed G, Key B, Mok SS, Beyreuther K, Masters CL, Nurcombe V. 1999. Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease. J Alzheimers Dis 1:275–285.
-
(1999)
J Alzheimers Dis
, vol.1
, pp. 275-285
-
-
Small, D.H.1
Clarris, H.L.2
Williamson, T.G.3
Reed, G.4
Key, B.5
Mok, S.S.6
Beyreuther, K.7
Masters, C.L.8
Nurcombe, V.9
-
153
-
-
0028168596
-
Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury
-
Smith-Swintosky VL, Pettigrew LC, Craddock SD, Culwell AR, Rydel RE, Mattson MP. 1994. Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury. J Neurochem 63:781–784.
-
(1994)
J Neurochem
, vol.63
, pp. 781-784
-
-
Smith-Swintosky, V.L.1
Pettigrew, L.C.2
Craddock, S.D.3
Culwell, A.R.4
Rydel, R.E.5
Mattson, M.P.6
-
154
-
-
84894102112
-
The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model
-
Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE. 2014. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res 1551:25–44.
-
(2014)
Brain Res
, vol.1551
, pp. 25-44
-
-
Spilman, P.1
Descamps, O.2
Gorostiza, O.3
Peters-Libeu, C.4
Poksay, K.S.5
Matalis, A.6
Campagna, J.7
Patent, A.8
Rao, R.9
John, V.10
Bredesen, D.E.11
-
155
-
-
85011738907
-
Enhancement of sAPPα as a therapeutic strategy for Alzheimer's and other neurodegenerative diseases
-
Spilman P, Bredesen D, Jagodzinska B, John V. 2015. Enhancement of sAPPα as a therapeutic strategy for Alzheimer's and other neurodegenerative diseases. HOSA J Alzheimers Neurodegen Dis 1:10.
-
(2015)
HOSA J Alzheimers Neurodegen Dis
, vol.1
, pp. 10
-
-
Spilman, P.1
Bredesen, D.2
Jagodzinska, B.3
John, V.4
-
156
-
-
4444255624
-
Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis
-
Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA. 2004. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 24:7707–7717.
-
(2004)
J Neurosci
, vol.24
, pp. 7707-7717
-
-
Stein, T.D.1
Anders, N.J.2
DeCarli, C.3
Chan, S.L.4
Mattson, M.P.5
Johnson, J.A.6
-
157
-
-
80051696970
-
Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis
-
Steinacker P, Fang L, Kuhle J, Petzold A, Tumani H, Ludolph AC, Otto M, Brettschneider J. 2011. Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis. PloS One 6:e23600.
-
(2011)
PloS One
, vol.6
-
-
Steinacker, P.1
Fang, L.2
Kuhle, J.3
Petzold, A.4
Tumani, H.5
Ludolph, A.C.6
Otto, M.7
Brettschneider, J.8
-
158
-
-
84956617728
-
Endothelial LRP1 transports amyloid-beta1–42 across the blood–brain barrier
-
Storck SE, Meister S, Nahrath J, Meissner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU. 2016. Endothelial LRP1 transports amyloid-beta1–42 across the blood–brain barrier. J Clin Invest 126:123–136.
-
(2016)
J Clin Invest
, vol.126
, pp. 123-136
-
-
Storck, S.E.1
Meister, S.2
Nahrath, J.3
Meissner, J.N.4
Schubert, N.5
Di Spiezio, A.6
Baches, S.7
Vandenbroucke, R.E.8
Bouter, Y.9
Prikulis, I.10
Korth, C.11
Weggen, S.12
Heimann, A.13
Schwaninger, M.14
Bayer, T.A.15
Pietrzik, C.U.16
-
159
-
-
48749121982
-
Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death
-
Taylor AL, Bonventre JV, Uliasz TF, Hewett JA, Hewett SJ. 2008. Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death. J Neurochem 106:1828–1840.
-
(2008)
J Neurochem
, vol.106
, pp. 1828-1840
-
-
Taylor, A.L.1
Bonventre, J.V.2
Uliasz, T.F.3
Hewett, J.A.4
Hewett, S.J.5
-
160
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. 1991. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572–580.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
161
-
-
33745263255
-
Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats
-
Thornton E, Vink R, Blumbergs PC, Van Den Heuvel C. 2006. Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats. Brain Res 1094:38–46.
-
(2006)
Brain Res
, vol.1094
, pp. 38-46
-
-
Thornton, E.1
Vink, R.2
Blumbergs, P.C.3
Van Den Heuvel, C.4
-
162
-
-
0042634362
-
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
-
Turner PR, O'Connor K, Tate WP, Abraham WC. 2003. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1–32.
-
(2003)
Prog Neurobiol
, vol.70
, pp. 1-32
-
-
Turner, P.R.1
O'Connor, K.2
Tate, W.P.3
Abraham, W.C.4
-
163
-
-
0026572465
-
Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients
-
Van Nostrand WE, Wagner SL, Shankle WR, Farrow JS, Dick M, Rozemuller JM, Kuiper MA, Wolters EC, Zimmerman J, Cotman CW, et al. 1992. Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc Natl Acad Sci U S A 89:2551–2555.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 2551-2555
-
-
Van Nostrand, W.E.1
Wagner, S.L.2
Shankle, W.R.3
Farrow, J.S.4
Dick, M.5
Rozemuller, J.M.6
Kuiper, M.A.7
Wolters, E.C.8
Zimmerman, J.9
Cotman, C.W.10
-
164
-
-
79955655453
-
Activation of the alpha-secretase processing of AbetaPP as a therapeutic approach in Alzheimer's disease
-
Vincent B, Govitrapong P. 2011. Activation of the alpha-secretase processing of AbetaPP as a therapeutic approach in Alzheimer's disease. J Alzheimers Dis 24(Suppl 2):75–94.
-
(2011)
J Alzheimers Dis
, vol.24
, pp. 75-94
-
-
Vincent, B.1
Govitrapong, P.2
-
165
-
-
0034889517
-
Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
-
Vincent B, Smith JD. 2001. Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner. Eur J Neurosci 14:256–266.
-
(2001)
Eur J Neurosci
, vol.14
, pp. 256-266
-
-
Vincent, B.1
Smith, J.D.2
-
166
-
-
4143105782
-
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain
-
Wang Y, Ha Y. 2004. The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol Cell 15:343–353.
-
(2004)
Mol Cell
, vol.15
, pp. 343-353
-
-
Wang, Y.1
Ha, Y.2
-
167
-
-
0024550204
-
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
-
Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K. 1989. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57:115–126.
-
(1989)
Cell
, vol.57
, pp. 115-126
-
-
Weidemann, A.1
Konig, G.2
Bunke, D.3
Fischer, P.4
Salbaum, J.M.5
Masters, C.L.6
Beyreuther, K.7
-
168
-
-
79957909084
-
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
-
Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jaschke A, Korte M, Wolfer DP, Caldwell JH, Muller UC. 2011. APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J 30:2266–2280.
-
(2011)
EMBO J
, vol.30
, pp. 2266-2280
-
-
Weyer, S.W.1
Klevanski, M.2
Delekate, A.3
Voikar, V.4
Aydin, D.5
Hick, M.6
Filippov, M.7
Drost, N.8
Schaller, K.L.9
Saar, M.10
Vogt, M.A.11
Gass, P.12
Samanta, A.13
Jaschke, A.14
Korte, M.15
Wolfer, D.P.16
Caldwell, J.H.17
Muller, U.C.18
-
169
-
-
0025095256
-
Beta-amyloid protein promotes neuritic branching in hippocampal cultures
-
Whitson JS, Glabe CG, Shintani E, Abcar A, Cotman CW. 1990. Beta-amyloid protein promotes neuritic branching in hippocampal cultures. Neurosci Lett 110:319–324.
-
(1990)
Neurosci Lett
, vol.110
, pp. 319-324
-
-
Whitson, J.S.1
Glabe, C.G.2
Shintani, E.3
Abcar, A.4
Cotman, C.W.5
-
170
-
-
10544230644
-
Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth
-
Williamson TG, Mok SS, Henry A, Cappai R, Lander AD, Nurcombe V, Beyreuther K, Masters CL, Small DH. 1996. Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth. J Biol Chem 271:31215–31221.
-
(1996)
J Biol Chem
, vol.271
, pp. 31215-31221
-
-
Williamson, T.G.1
Mok, S.S.2
Henry, A.3
Cappai, R.4
Lander, A.D.5
Nurcombe, V.6
Beyreuther, K.7
Masters, C.L.8
Small, D.H.9
-
171
-
-
77954176653
-
Memory formation and long-term retention in humans and animals: convergence toward a transformation account of hippocampal-neocortical interactions
-
Winocur G, Moscovitch M, Bontempi B. 2010. Memory formation and long-term retention in humans and animals: convergence toward a transformation account of hippocampal-neocortical interactions. Neuropsychologia 48:2339–2356.
-
(2010)
Neuropsychologia
, vol.48
, pp. 2339-2356
-
-
Winocur, G.1
Moscovitch, M.2
Bontempi, B.3
-
172
-
-
84936145573
-
Astrocytes regulate alpha-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: involvement of group IIA secretory phospholipase A2
-
Yang X, Sheng W, Ridgley DM, Haidekker MA, Sun GY, Lee JC. 2015. Astrocytes regulate alpha-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: involvement of group IIA secretory phospholipase A2. Neuroscience 300:508–517.
-
(2015)
Neuroscience
, vol.300
, pp. 508-517
-
-
Yang, X.1
Sheng, W.2
Ridgley, D.M.3
Haidekker, M.A.4
Sun, G.Y.5
Lee, J.C.6
-
173
-
-
46149126877
-
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
-
Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. 2008. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev 3:15.
-
(2008)
Neural Dev
, vol.3
, pp. 15
-
-
Young-Pearse, T.L.1
Chen, A.C.2
Chang, R.3
Marquez, C.4
Selkoe, D.J.5
-
174
-
-
0028945660
-
Evidence that Aβ42 is the real culprit in Alzheimer's disease
-
Younkin SG. 1995. Evidence that Aβ42 is the real culprit in Alzheimer's disease. Ann Neurol 37:287–288.
-
(1995)
Ann Neurol
, vol.37
, pp. 287-288
-
-
Younkin, S.G.1
-
175
-
-
66049148147
-
Biological CSF markers of Alzheimer's disease
-
Zetterberg H, Blennow K. 2008. Biological CSF markers of Alzheimer's disease. Hndbk Clin Neurol 89:261–268.
-
(2008)
Hndbk Clin Neurol
, vol.89
, pp. 261-268
-
-
Zetterberg, H.1
Blennow, K.2
-
176
-
-
0028988801
-
Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisoda SS, Chen HY, Van der Ploeg LH. 1995. Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525–531.
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Sirinathsinghji, D.J.4
Hopkins, R.5
Smith, D.W.6
Heavens, R.P.7
Dawson, G.R.8
Boyce, S.9
Conner, M.W.10
Stevens, K.A.11
Slunt, H.H.12
Sisoda, S.S.13
Chen, H.Y.14
Van der Ploeg, L.H.15
-
177
-
-
0029873515
-
Mice deficient for the amyloid precursor protein gene
-
Zheng H, Jiang M, Trumbauer ME, Hopkins R, Sirinathsinghji DJ, Stevens KA, Conner MW, Slunt HH, Sisodia SS, Chen HY, Van der Ploeg LH. 1996. Mice deficient for the amyloid precursor protein gene. Ann N Y Acad Sci 777:421–426.
-
(1996)
Ann N Y Acad Sci
, vol.777
, pp. 421-426
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Hopkins, R.4
Sirinathsinghji, D.J.5
Stevens, K.A.6
Conner, M.W.7
Slunt, H.H.8
Sisodia, S.S.9
Chen, H.Y.10
Van der Ploeg, L.H.11
-
178
-
-
0028275855
-
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
-
Zhuo M, Hu Y, Schultz C, Kandel ER, Hawkins RD. 1994. Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368:635–639.
-
(1994)
Nature
, vol.368
, pp. 635-639
-
-
Zhuo, M.1
Hu, Y.2
Schultz, C.3
Kandel, E.R.4
Hawkins, R.D.5
|