Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSw mice resulting in tau phosphorylation and loss of hippocampal neurons: Support for the amyloid hypothesis

Journal of Neuroscience

Volumn 24, Issue 35, 2004, Pages 7707-7717

  Stein, Thor D ^a   Anders, Nicholas J ^a   DeCarli, Charles ^c   Chan, Sic L ^d   Mattson, Mark P ^d   Johnson, Jeffrey A ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

secretase; amyloid; Alzheimer's disease; Neurodegeneration; Neuropathology; Neuroprotection; Neurotrophic; Organotypic slice culture

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; IMMUNOGLOBULIN G ANTIBODY; MESSENGER RNA; PREALBUMIN; SMALL INTERFERING RNA; SOMATOMEDIN B; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ENDOPEPTIDASES; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; ENDOPEPTIDASES; HIPPOCAMPUS; HUMANS; INSULIN-LIKE GROWTH FACTOR II; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; NERVE DEGENERATION; NERVE TISSUE PROTEINS; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PREALBUMIN; PROMOTER REGIONS (GENETICS); PROTEIN PROCESSING, POST-TRANSLATIONAL; PRPC PROTEINS; RECEPTORS, CELL SURFACE; RNA, SMALL INTERFERING; TAU PROTEINS; TRANSGENES;

EID: 4444255624     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2211-04.2004     Document Type: Article

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