Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein

Experimental Neurology

Volumn 175, Issue 2, 2002, Pages 407-414

  Cheng, Guanjun ^a,b   Yu, ZaiFang ^b   Zhou, Daohong ^b   Mattson, Mark P ^a,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt kinase; Alzheimer's disease; Apoptosis; Glutamate; GSK 3 ; Hippocampus; Neurotrophic factor

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLUTAMIC ACID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P44; WORTMANNIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN CELL; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; HIPPOCAMPUS; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION;

EID: 0036285116     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.7920     Document Type: Article

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