Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

Acta Neuropathologica

Volumn 131, Issue 2, 2016, Pages 247-266

  Fol, Romain ^a,b,c   Braudeau, Jerome ^a,b   Ludewig, Susann ^g   Abel, Tobias ^f   Weyer, Sascha W ⁱ   Roederer, Jan Peter ⁱ   Brod, Florian ^f   Audrain, Mickael ^a,b,c   Bemelmans, Alexis Pierre ^b,d,e   Buchholz, Christian J ^f   Korte, Martin ^g,h   Cartier, Nathalie ^a,b   Müller, Ulrike C ⁱ  

^a Molecular Imaging Research Center   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^e CNRS   (France)

^f PAUL EHRLICH INSTITUT   (Germany)

^g TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^h HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

ⁱ UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

AAV; Alzheimer; Amyloid precursor protein; APPs ; Behavior; Gene therapy; Microglia; Spines; Synaptic plasticity

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; SYNAPSIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; VIRUS VECTOR; APP PROTEIN, HUMAN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN; SECRETASE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CHEMOLUMINESCENCE; COGNITION; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; DORSAL HIPPOCAMPUS; ELECTROCHEMILUMINESCENCE; ELECTROPHYSIOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; HIPPOCAMPAL CA3 REGION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LONG TERM POTENTIATION; MICROGLIA; MORRIS WATER MAZE TEST; MOTOR PERFORMANCE; MOUSE; MUSCULOSKELETAL SYSTEM PARAMETERS; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PYRAMIDAL NERVE CELL; REFERENCE MEMORY; SPATIAL MEMORY; SPINE DENSITY; STRATUM LACUNOSUM MOLECULARE; SUBICULUM; SYNAPTIC FAILURE; SYNAPTIC TRANSMISSION; ULTRACENTRIFUGATION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WESTERN BLOTTING; WILD TYPE; ADMINISTRATION AND DOSAGE; ANIMAL; BRAIN; DEPENDOPARVOVIRUS; DISEASE MODEL; GENE THERAPY; GENE VECTOR; GENETICS; HIPPOCAMPUS; HUMAN; MALE; MAZE TEST; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SYNAPSE; TISSUE CULTURE TECHNIQUE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENETIC THERAPY; GENETIC VECTORS; HIPPOCAMPUS; HUMANS; MALE; MAZE LEARNING; MICE, TRANSGENIC; MICROGLIA; NEURONS; PLAQUE, AMYLOID; PRESENILIN-1; SYNAPSES; TISSUE CULTURE TECHNIQUES;

EID: 84954377011     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1498-9     Document Type: Article

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