Secreted β-amyloid precursor protein activates microglia via JNK and p38-MAPK

Neurobiology of Aging

Volumn 26, Issue 1, 2005, Pages 9-16

  Bodles, Angela M ^a   Barger, Steven W ^a,b,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Alzheimer's disease; APP; Inflammation; MAP kinase; Microglia; Nitric oxide synthase; Stress activated kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMYLOID BETA PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRITE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ASSAY; MICROGLIA; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; ANTHRACENES; BLOTTING, WESTERN; BUTADIENES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICROGLIA; NITRILES; NITRITES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RATS; TIME FACTORS;

EID: 10044235332     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2004.02.022     Document Type: Article

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