Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 12, 2010, Pages 5381-5386

  Dahms, Sven O ^a   Hoefgen, Sandra ^a   Roeser, Dirk ^a   Schlott, Bernhard ^b   Gührs, Karl Heinz ^b   Than, Manuel E ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b Biochemistry Group   (Germany)

Author keywords

Alzheimer's disease; Crystal structure; Domain domain interaction; Isothermal titration calorimetry; Static light scattering

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COPPER; DIMER; GLYCOPROTEIN E1; GROWTH FACTOR; HEPARIN; SUGAR;

AMINO TERMINAL SEQUENCE; ARTICLE; CELLULAR DISTRIBUTION; CHEMICAL ANALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; DISSOCIATION CONSTANT; EXTRACELLULAR MATRIX; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; BIOPHYSICAL PHENOMENA; CRYSTALLOGRAPHY, X-RAY; HEPARIN; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

MAMMALIA;

EID: 77950385325     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911326107     Document Type: Article

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