SAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

Molecular and Cellular Neuroscience

Volumn 44, Issue 4, 2010, Pages 386-393

  Copanaki, Ekaterini ^a,b   Chang, Steffi ^b   Vlachos, Andreas ^a   Tschäpe, Jakob A ^c   Müller, Ulrike C ^c   Kögel, Donat ^b   Deller, Thomas ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Alpha secretase; Alzheimer's disease; Epoxomicin; Organotypic slice cultures; Stress signalling

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CASPASE 3; EPOXOMICIN; GREEN FLUORESCENT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME INHIBITOR; PROTEIN KINASE B; SECRETED CLEAVAGE PRODUCT OF BETA AMYLOID PRECURSOR PROTEIN ALPHA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; HYBRID PROTEIN; MORPHOLINE DERIVATIVE; OLIGOPEPTIDE; PROTEASOME; SECRETASE; THY 1 ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SECRETION; CELL STRAIN; CELL STRUCTURE; CELLULAR STRESS SIGNAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITE; ENZYME ACTIVATION; GENOTOXICITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION; ULTRAVIOLET IRRADIATION; ALZHEIMER DISEASE; ANIMAL; CELL CULTURE; CHEMISTRY; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; DENDRITIC SPINE; DRUG ANTAGONISM; METABOLISM; NERVE DEGENERATION; PATHOLOGY; PHYSIOLOGY; RADIATION EXPOSURE; RAT; ULTRAVIOLET RADIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIGENS, THY-1; APOPTOSIS; CA1 REGION, HIPPOCAMPAL; CELLS, CULTURED; CHROMONES; CULTURE MEDIA, CONDITIONED; CULTURE TECHNIQUES; DENDRITIC SPINES; ENZYME INHIBITORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICROSCOPY, CONFOCAL; MORPHOLINES; NERVE DEGENERATION; OLIGOPEPTIDES; PC12 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RECOMBINANT FUSION PROTEINS; ULTRAVIOLET RAYS;

EID: 77953958809     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2010.04.007     Document Type: Article

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