What is the role of amyloid precursor protein dimerization?

Cell Adhesion and Migration

Volumn 4, Issue 2, 2010, Pages 268-272

  Khalifa, Naouel Ben ^a   Van Hees, Joanne ^b   Tasiaux, Bernadette ^a   Huysseune, Sandra ^a   Smith, Steven O ^c   Constantinescu, Stefan N ^b   Octave, Jean Noël ^a   Kienlen Campard, Pascal ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Alzheimer; Amyloid; APP; Dimerization; GxxxG; Processing; Secretase

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CELL ADHESION MOLECULE; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PEPTIDE DERIVATIVE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CELL TYPE; COMPLEX FORMATION; DIMERIZATION; EXTRACELLULAR MATRIX; IMMUNOTHERAPY; LONG TERM POTENTIATION; MEMBRANE FORMATION; MOLECULE; NONHUMAN; OLIGOMERIZATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; HUMAN; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DIMERIZATION; HUMANS; MODELS, BIOLOGICAL;

EID: 77953582321     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.4.2.11476     Document Type: Review

References (36)

1. Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987; 325:733-6.
2. Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, et al. beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 1995; 81:525-31.
3. Chen Y, Tang BL. The amyloid precursor protein and postnatal neurogenesis/neuroregeneration. Biochem Biophys Res Commun 2006; 341:1-5.
4. Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286:735-41.
5. Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol 2002; 3:673-84.
6. Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, et al. Active gamma-secretase complexes contain only one of each component. J Biol Chem 2007; 282:33985-93.
7. Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem 2001; 78:1168-78.
8. Muresan Z, Muresan V. A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment. Hum Mol Genet 2004; 13:475-88.
9. Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves dC, Vincent B, et al. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 2005; 46:541-54.
10. Hebert SS, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov MA, et al. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep 2006; 7:739-45.
11. Beher D, Hesse L, Masters CL, Multhaup G. Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem 1996; 271:1613-20.
12. Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 2002; 110:669-72.
13. Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, et al. Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J 2005; 24:3624-34.
14. Bormann BJ, Knowles WJ, Marchesi VT. Synthetic peptides mimic the assembly of transmembrane glycoproteins. J Biol Chem 1989; 264:4033-7.
15. Lemmon MA, Treutlein HR, Adams PD, Brunger AT, Engelman DM. A dimerization motif for transmembrane alpha-helices. Nat Struct Biol 1994; 1:157-63.
16. Smith SO, Song D, Shekar S, Groesbeek M, Ziliox M, Aimoto S. Structure of the transmembrane dimer interface of glycophorin A in membrane bilayers. Biochemistry 2001; 40:6553-8.
17. Russ WP, Engelman DM. The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol 2000; 296:911-9.
18. Eilers M, Patel AB, Liu W, Smith SO. Comparison of helix interactions in membrane and soluble alpha-bundle proteins. Biophys J 2002; 82:2720-36. (Pubitemid 34441309)
19. Javadpour MM, Eilers M, Groesbeek M, Smith SO. Helix packing in polytopic membrane proteins: role of glycine in transmembrane helix association. Biophys J 1999; 77:1609-18. (Pubitemid 29407334)
20. Sato T, Tang TC, Reubins G, Fei JZ, Fujimoto T, Kienlen-Campard P, et al. A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. Proc Natl Acad Sci USA 2009; 106:1421-6.
21. Munter LM, Voigt P, Harmeier A, Kaden D, Gottschalk KE, Weise C, et al. GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J 2007; 26:1702-12.
22. Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, et al. Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs. J Biol Chem 2008; 283:7733-44.
23. Russ WP, Engelman DM. TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc Natl Acad Sci USA 1999; 96:863-8.
24. Kaden D, Munter LM, Joshi M, Treiber C, Weise C, Bethge T, et al. Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. J Biol Chem 2008; 283:7271-9.
25. Wang Y, Ha Y. The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol Cell 2004; 15:343-53.
26. Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci 2007; 27:14459-69.
27. Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, et al. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem 2001; 276:33923-9.
28. Kienlen-Campard P, Miolet S, Tasiaux B, Octave JN. Intracellular amyloid-beta1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. J Biol Chem 2002; 277:15666-70.
29. Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, et al. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 2002; 41:2825-35.
30. Huysseune S, Kienlen-Campard P, Hebert S, Tasiaux B, Leroy K, Devuyst O, et al. Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. FASEB J 2009; 12:4158-67.
31. Kajiwara Y, Akram A, Katsel P, Haroutunian V, Schmeidler J, Beecham G, et al. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One 2009; 4:5071.
32. Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, et al. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex. J Biol Chem 2004; 279:4144-52.
33. Sato T, Kienlen-Campard P, Ahmed M, Liu W, Li H, Elliott JI, et al. Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry 2006; 45:5503-16.
34. Ren Z, Schenk D, Basi GS, Shapiro IP. Amyloid-Protein Precursor Juxtamembrane Domain Regulates Specificity of gamma-Secretase-dependent Cleavages. J Biol Chem 2007; 282:35350-60.
35. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, et al. Substrate-targeting gamma-secretase modulators. Nature 2008; 453:925-9.
36. Tampellini D, Magrane J, Takahashi RH, Li F, Lin MT, Almeida CG, et al. Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem 2007; 282:18895-906.