Mice deficient for the amyloid precursor protein gene

Annals of the New York Academy of Sciences

Volumn 777, Issue , 1996, Pages 421-426

  Zheng, H ^a,d   Jiang, M ^a   Trumbauer, M E ^a   Hopkins, R ^b   Sirinathsinghji, D J S ^b   Stevens, K A ^a   Conner, M W ^a   Slunt, H H ^c   Sisodia, S S ^c   Chen, H Y ^a   Van Der Ploeg, L H T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Biostatist and Res Data Systems   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE FREQUENCY; GENE MUTATION; GENETIC RECOMBINATION; HOMOZYGOTE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROANATOMY; NEWBORN; NONHUMAN; STEM CELL;

ANIMALIA;

EID: 0029873515     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb34456.x     Document Type: Conference Paper

References (19)

1. LAMB, B. T., S. SISODIA, A. LAWLER, H. SLUNT, C. KITT, W. KEARNS, P. PEARSON, D. PRICE & J. GEARHART. 1993. Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice. Nature Genet. 5:22-30.
2. YOSHIKAI, S.-I., H. SASAKI, K. DOH-URA, H. FURUYA & Y. SAKAKI. 1990. Genomic organization of the human amyloid β-protein precursor gene. Gene 87:257-263.
3. KOSIK, K. S. 1992. Alzheimer's disease: A cell biological perspective. Science 256:780-783.
4. MATTSON, M. P., B. CHENG, A. R. CULWELL, F. S. ESCH, I. LIEBERBURG & E. R. RUSSEL. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10:243-254.
5. NILWARD, E. A., R. PAPADOPOULOS, S. J. FULLER, R. D. MOIR, D. SMALL, D. BEYREUTHER & C. L. MASTERS. 1992. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9:129-137.
6. PONTE, P., P. GONZALEZ-DEWHITT, J. SCHILLING, J. MILLER, D. HSU, B. GREENBERG, K. DAVIS, W. WALLACE, I. LIEBERBURG, F. FULLER & B. CORDELL. 1988. A new A4 amyloid mRNA contain a domain homologous to serine proteinase inhibitors. Nature 331:525-527.
7. SIROH, R., M. SUNDAMO, J.-M. ROCH, N. KIMURA, G. COLE, D. SCHUBER, T. OLTERSDORF & D. SCHENK. 1989. Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts. Cell 58:615-622.
8. SCHUBERT, D., L.-W. JIN, T. SAITOH & G. COLE. 1989. The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion. Neuron 3:689-694.
9. RAMIREZ-SOLIS, R., J. RIVERA-PEREZ, J. D. WALLACE, M. WIMS, H. ZHENG & A. BRADLEY. 1992. Genomic DNA microextraction: A method to screen numerous samples. Anal. Biochem. 201:331-335.
10. ZHENG, H., M. JIANG, M. TRUMBAUER, D. SIRINATHSINGHJI, R. HOPKINS, D. SMITH, R. HEAVENS, G. DAWSON, S. BOYCE, M. CONNER, K. STEVENS, H. SLUNT, S. SISODIA, H. CHEN & L. VAN DER PLOEG. 1995. β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-531.
11. IZUMI, R., T. YAMADA, S.-I. YOSHIKAI, H. SASAKI, M. HATTORI & Y. SAKAKI. 1992. Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse. Gene 112:189-195.
12. YAMADA, T., H. SAKASI, H. FURNYA, T. MIYATA, I. GOTO & Y. SAKAKI. 1987. Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. Biochem. Biophys. Res. Commun. 149:665-671.
13. DAIGLE, I. & C. LI. 1993. Ap1-1, a Caenorhabditis elegans gene encoding a protein related to the human β-amyloid protein precursor. Proc. Natl. Acad. Sci. USA 90:12045-12049.
14. ROSEN, D. R., L. MARTIN-MORRIS, L. LOU & K. WHITE. 1989. A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. Proc. Natl. Acad. Sci. USA 86:2478-2482.
15. SLUNT, H. H., G. THINAKARAN, C. VAN KOCH, A. C. Y. LO, R. E. TANZI & S. S. SISODIA. 1994. Expression of a ubiquitous, cross-reactive homologue of the mous β-amyloid precursor protein (APP). J. Biol. Chem. 269:2637-2644.
16. WASCO, W., K. BUPP, M. MAGENDANTZ, J. GUSELLA, R. TANZI & F. SOLOMON. 1992. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid βprotein precursor. Proc. Natl. Acad. Sci. USA 89:10758-10762.
17. LUO, L., T. TULLY & K. WHITE. 1992. Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9:595-605.
18. MÜLLER, U., N. CRISTINA, Z. W. LI, et al. 1994. Behavioral and anatomical deficits in mice homozygous for a modified β-amyloid precursor protein gene. Cell 79:755-765.
19. PRICE, D. L. & S. S. SISODIA. 1994. Cellular and molecular biology of Alzheimer's disease and animal models. Annu. Rev. Med. 45:435-447.