The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species

Journal of Biological Chemistry

Volumn 287, Issue 40, 2012, Pages 33304-33313

  Bien, Jessica ^a   Jefferson, Tamara ^b   Čaušević, Mirsada ^a   Jumpertz, Thorsten ^c   Munter, Lisa ^d   Multhaup, Gerd ^d   Weggen, Sascha ^c   Becker Pauly, Christoph ^b   Pietrzik, Claus U ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMINO ACID RESIDUES; AMYLOID PRECURSOR PROTEINS; CLEAVAGE SITES; ENZYMATIC ACTIVITIES; KINETIC VALUES; KNOCK OUTS; METALLO-PROTEASE; N-TERMINALS; SECRETASES; WILD TYPES;

AMINO ACIDS; PEPTIDES;

GLYCOPROTEINS;

AMINO ACID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; BETA SECRETASE 2; BETA SECRETASE INHIBITOR; MEPRIN BETA; METALLOPROTEINASE; MUTANT PROTEIN; PROTEIN VARIANT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; BRAIN; CATALYSIS; HEK293 CELLS; HUMANS; HYDROXAMIC ACIDS; KINETICS; METALLOENDOPEPTIDASES; METALLOPROTEASES; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEOMICS;

EID: 84866893131     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.395608     Document Type: Article

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