메뉴 건너뛰기




Volumn 278, Issue 16, 1997, Pages 1349-1356

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4;

EID: 0030823158     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.278.16.1349     Document Type: Review
Times cited : (3686)

References (85)
  • 1
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin M-C, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991;349:704-706.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.-C.2    Mullan, M.3
  • 2
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995;375: 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 3
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 1995;269:973-977.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 4
    • 0002687033 scopus 로고    scopus 로고
    • Genetics and the dementia patient
    • Farrer LA. Genetics and the dementia patient. Neurologist. 1997;3:13-30.
    • (1997) Neurologist , vol.3 , pp. 13-30
    • Farrer, L.A.1
  • 5
    • 0027193817 scopus 로고
    • Genetic mutations affecting human lipoproteins, their receptors, and their enzymes
    • Zannis VI, Kardassis D, Zannis EE. Genetic mutations affecting human lipoproteins, their receptors, and their enzymes. Adv Hum Genet. 1993;21: 145-319.
    • (1993) Adv Hum Genet. , vol.21 , pp. 145-319
    • Zannis, V.I.1    Kardassis, D.2    Zannis, E.E.3
  • 6
    • 0027407565 scopus 로고
    • Apolipoprotein E: High avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:1977-1981.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3
  • 7
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1467-1472.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 9
    • 0028178047 scopus 로고
    • Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease
    • Chartier-Harlin M-C, Parfitt M, Legrain S, et al. Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease. Hum Mol Genet. 1994;3:569-574.
    • (1994) Hum Mol Genet. , vol.3 , pp. 569-574
    • Chartier-Harlin, M.-C.1    Parfitt, M.2    Legrain, S.3
  • 10
    • 17444451748 scopus 로고
    • ApoE-epsilon 4 and early-onset Alzheimer's
    • Okuizumi K, Onodera O, Tanaka H, et al. ApoE-epsilon 4 and early-onset Alzheimer's. Nat Genet. 1994;7:10-11.
    • (1994) Nat Genet. , vol.7 , pp. 10-11
    • Okuizumi, K.1    Onodera, O.2    Tanaka, H.3
  • 11
    • 0028026997 scopus 로고
    • Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease
    • van Duijn CM, de Knijff P, Cruts M, et al. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet. 1994;7: 74-78.
    • (1994) Nat Genet. , vol.7 , pp. 74-78
    • Van Duijn, C.M.1    De Knijff, P.2    Cruts, M.3
  • 12
    • 0027946816 scopus 로고
    • Predictive value of apolipoprotein E genotyping in Alzheimer's disease
    • Nalbantoglu J, Gilfix BM, Bertrand P, et al. Predictive value of apolipoprotein E genotyping in Alzheimer's disease. Ann Neurol. 1994;36:889-895.
    • (1994) Ann Neurol. , vol.36 , pp. 889-895
    • Nalbantoglu, J.1    Gilfix, B.M.2    Bertrand, P.3
  • 13
    • 0000855672 scopus 로고
    • Measuring the genetic contribution of APOE in late-onset Alzheimer disease
    • Abstract
    • Roses AD, Devlin B, Conneally PM, et al. Measuring the genetic contribution of APOE in late-onset Alzheimer disease. Am J Hum Genet. 1995; 57:A202. Abstract.
    • (1995) Am J Hum Genet. , vol.57
    • Roses, A.D.1    Devlin, B.2    Conneally, P.M.3
  • 14
    • 0030273357 scopus 로고    scopus 로고
    • Apolipoprotein E in Alzheimer's disease risk and case detection: A case-control study
    • Kukull WA, Schellenberg GD, Bowen JD, et al. Apolipoprotein E in Alzheimer's disease risk and case detection: a case-control study. J Clin Epidemiol. 1996;49:1143-1148.
    • (1996) J Clin Epidemiol. , vol.49 , pp. 1143-1148
    • Kukull, W.A.1    Schellenberg, G.D.2    Bowen, J.D.3
  • 15
    • 0028305380 scopus 로고
    • Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
    • Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. 1994;7:180-184.
    • (1994) Nat Genet. , vol.7 , pp. 180-184
    • Corder, E.H.1    Saunders, A.M.2    Risch, N.J.3
  • 16
    • 0028137052 scopus 로고
    • ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease
    • Sorbi S, Nacmias B, Forleo P, et al. ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease. Neurosci Lett. 1994;177:100-102.
    • (1994) Neurosci Lett. , vol.177 , pp. 100-102
    • Sorbi, S.1    Nacmias, B.2    Forleo, P.3
  • 17
    • 0028988736 scopus 로고
    • The apolipoprotein E ε2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival
    • van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E ε2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol. 1995;37:605-610.
    • (1995) Ann Neurol. , vol.37 , pp. 605-610
    • Van Duijn, C.M.1    De Knijff, P.2    Wehnert, A.3
  • 18
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 19
    • 0027169478 scopus 로고
    • Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19
    • Borgaonkar DS, Schmidt LC, Martin SE, et al. Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19. Lancet. 1993;342:625.
    • (1993) Lancet , vol.342 , pp. 625
    • Borgaonkar, D.S.1    Schmidt, L.C.2    Martin, S.E.3
  • 21
    • 0028035306 scopus 로고
    • Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau
    • Strittmatter WJ, Saunders AM, Goedert M, et al. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau. Proc Natl Acad Sci U S A. 1994;91:11183-11186.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11183-11186
    • Strittmatter, W.J.1    Saunders, A.M.2    Goedert, M.3
  • 22
    • 0028172930 scopus 로고
    • Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease
    • Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci. 1994;17:525-530.
    • (1994) Trends Neurosci. , vol.17 , pp. 525-530
    • Poirier, J.1
  • 23
    • 0029754637 scopus 로고    scopus 로고
    • Alzheimer amyloid-β peptide forms denaturant-resistant complex with type ε3 but not type ε4 isoform of native apolipoprotein E
    • Zhou Z, Smith JD, Greengard P, Gandy S. Alzheimer amyloid-β peptide forms denaturant-resistant complex with type ε3 but not type ε4 isoform of native apolipoprotein E. Mol Med. 1996;2: 175-180.
    • (1996) Mol Med. , vol.2 , pp. 175-180
    • Zhou, Z.1    Smith, J.D.2    Greengard, P.3    Gandy, S.4
  • 24
    • 0029664414 scopus 로고    scopus 로고
    • Apolipoprotein E ε4 association with dementia in a population based study: The Framingham Study
    • Myers RH, Schaefer EJ, Wilson PWF, et al. Apolipoprotein E ε4 association with dementia in a population based study: the Framingham Study. Neurology. 1996;46:673-677.
    • (1996) Neurology , vol.46 , pp. 673-677
    • Myers, R.H.1    Schaefer, E.J.2    Wilson, P.W.F.3
  • 25
    • 0028875375 scopus 로고
    • Apolipoprotein E allele ε4, dementia, and cognitive decline in a population sample
    • Henderson AS, Easteal S, Jorm AF, et al. Apolipoprotein E allele ε4, dementia, and cognitive decline in a population sample. Lancet. 1995;346:1387-1390.
    • (1995) Lancet , vol.346 , pp. 1387-1390
    • Henderson, A.S.1    Easteal, S.2    Jorm, A.F.3
  • 26
    • 0028805682 scopus 로고
    • Apolipoprotein E genotype in patients with Alzheimer disease
    • Farrer LA, Cupples LA, van Duijn CM, et al. Apolipoprotein E genotype in patients with Alzheimer disease. Ann Neurol. 1995;38:797-808.
    • (1995) Ann Neurol. , vol.38 , pp. 797-808
    • Farrer, L.A.1    Cupples, L.A.2    Van Duijn, C.M.3
  • 27
    • 0028325294 scopus 로고
    • Alzheimer's disease, apolipoprotein E4, and gender
    • Payami H, Montee KR, Kaye JA, et al. Alzheimer's disease, apolipoprotein E4, and gender. JAMA. 1994;271:1316-1317.
    • (1994) JAMA , vol.271 , pp. 1316-1317
    • Payami, H.1    Montee, K.R.2    Kaye, J.A.3
  • 28
    • 0029018224 scopus 로고
    • Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease
    • Mayeux R, Ottman R, Maestre G, et al. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology. 1995;45:565-557.
    • (1995) Neurology , vol.45 , pp. 565-1557
    • Mayeux, R.1    Ottman, R.2    Maestre, G.3
  • 29
    • 0028986481 scopus 로고
    • Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease
    • van Duijn CM, Havekes LM, Van Broeckhoven C, de Knijff P, Hofman A. Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease. BMJ. 1995;310:627-631.
    • (1995) BMJ , vol.310 , pp. 627-631
    • Van Duijn, C.M.1    Havekes, L.M.2    Van Broeckhoven, C.3    De Knijff, P.4    Hofman, A.5
  • 30
    • 0029072551 scopus 로고
    • Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
    • Jarvik GP, Wijsman EM, Kukull WA, Schellenberg GD, Yu C, Larson EB. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology. 1995;45:1092-1096.
    • (1995) Neurology , vol.45 , pp. 1092-1096
    • Jarvik, G.P.1    Wijsman, E.M.2    Kukull, W.A.3    Schellenberg, G.D.4    Yu, C.5    Larson, E.B.6
  • 31
    • 0002272413 scopus 로고    scopus 로고
    • Estrogen apolipoprotein E and the risk of Alzheimer's disease
    • Abstract
    • Van Duijn CM, Meijer H, Witteman JCM, et al. Estrogen apolipoprotein E and the risk of Alzheimer's disease. Neurobiol Aging. 1996;17(suppl):S79. Abstract.
    • (1996) Neurobiol Aging , vol.17 , Issue.SUPPL.
    • Van Duijn, C.M.1    Meijer, H.2    Witteman, J.C.M.3
  • 32
    • 0028169648 scopus 로고
    • Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals
    • Rebeck GW, Perls TT, West HL, Sodhi P, Lipsitz LA, Hyman BT. Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. Neurology. 1994;44:1513-1516.
    • (1994) Neurology , vol.44 , pp. 1513-1516
    • Rebeck, G.W.1    Perls, T.T.2    West, H.L.3    Sodhi, P.4    Lipsitz, L.A.5    Hyman, B.T.6
  • 33
    • 0029037609 scopus 로고
    • Lack of association of apolipoprotein E allele ε4 with late-onset Alzheimer disease among Finnish centenarians
    • Sobel E, Louhija J, Sulkava R, et al. Lack of association of apolipoprotein E allele ε4 with late-onset Alzheimer disease among Finnish centenarians. Neurology. 1995;45:903-907.
    • (1995) Neurology , vol.45 , pp. 903-907
    • Sobel, E.1    Louhija, J.2    Sulkava, R.3
  • 34
    • 0030049775 scopus 로고    scopus 로고
    • Attenuation of apolipoprotein E ε4 allele gene dose in late age
    • Corder EH, Basun H, Lannfelt L, Vitanen M, Winblad B. Attenuation of apolipoprotein E ε4 allele gene dose in late age. Lancet. 1996;347:542.
    • (1996) Lancet , vol.347 , pp. 542
    • Corder, E.H.1    Basun, H.2    Lannfelt, L.3    Vitanen, M.4    Winblad, B.5
  • 35
    • 0028816355 scopus 로고
    • Apolipoprotein E and Alzheimer's disease: Ethnic variation in genotypic risks
    • Maestre G, Ottman R, Stern Y, et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol. 1995;37:254-259.
    • (1995) Ann Neurol. , vol.37 , pp. 254-259
    • Maestre, G.1    Ottman, R.2    Stern, Y.3
  • 36
    • 0028961402 scopus 로고
    • Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans
    • Hendrie HC, Hall KS, Hui S, et al. Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans. Ann Neurol. 1995;37:118-120.
    • (1995) Ann Neurol. , vol.37 , pp. 118-120
    • Hendrie, H.C.1    Hall, K.S.2    Hui, S.3
  • 37
    • 0029083242 scopus 로고
    • Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians
    • Osuntokun BO, Sahota A, Ogunniyi AO, et al. Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. Ann Neurol. 1995;38:463-465.
    • (1995) Ann Neurol. , vol.38 , pp. 463-465
    • Osuntokun, B.O.1    Sahota, A.2    Ogunniyi, A.O.3
  • 38
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian Z. Diagnosis of Alzheimer's disease. Arch Neurol. 1985;42:1097-1105.
    • (1985) Arch Neurol. , vol.42 , pp. 1097-1105
    • Khachaturian, Z.1
  • 39
    • 0029558894 scopus 로고
    • Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy Body and Alzheimer's disease
    • Benjamin R, Leake A, Ince PG, et al. Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy Body and Alzheimer's disease. Neurodegeneration. 1995;4:443-448.
    • (1995) Neurodegeneration , vol.4 , pp. 443-448
    • Benjamin, R.1    Leake, A.2    Ince, P.G.3
  • 40
    • 0029930022 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and Alzheimer's disease in an elderly Norwegian cohort
    • Benjamin R, Leake A, McArthur FK, et al. Apolipoprotein E genotype and Alzheimer's disease in an elderly Norwegian cohort. Neurodegeneration. 1996;5:43-47.
    • (1996) Neurodegeneration , vol.5 , pp. 43-47
    • Benjamin, R.1    Leake, A.2    McArthur, F.K.3
  • 41
    • 0027933984 scopus 로고
    • Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia
    • Betard C, Robitaille Y, Gee M, et al. Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia. Neuroreport. 1994; 5:1893-1896.
    • (1994) Neuroreport , vol.5 , pp. 1893-1896
    • Betard, C.1    Robitaille, Y.2    Gee, M.3
  • 42
    • 17744410836 scopus 로고    scopus 로고
    • ApoE-4 and age at onset of Alzheimer's disease: The NIMH Genetics Initiative
    • Blacker D, Haines JL, Rodes L, et al. ApoE-4 and age at onset of Alzheimer's disease: the NIMH Genetics Initiative. Neurology. 1997;48:139-147.
    • (1997) Neurology , vol.48 , pp. 139-147
    • Blacker, D.1    Haines, J.L.2    Rodes, L.3
  • 43
    • 0030006546 scopus 로고    scopus 로고
    • Alzheimer's disease: Interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity and age of onset
    • Duara R, Barker WW, Lopez-Alberola R, et al. Alzheimer's disease: interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity and age of onset. Neurology. 1996; 46:1575-1579.
    • (1996) Neurology , vol.46 , pp. 1575-1579
    • Duara, R.1    Barker, W.W.2    Lopez-Alberola, R.3
  • 44
    • 0030976712 scopus 로고    scopus 로고
    • No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease and no interaction with the apolipoprotein E gene in population-based and clinic samples
    • Fallin D, Gauntlett AC, Scibelli P, et al. No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease and no interaction with the apolipoprotein E gene in population-based and clinic samples. Genet Epidemiol. 1997;14:299-305.
    • (1997) Genet Epidemiol. , vol.14 , pp. 299-305
    • Fallin, D.1    Gauntlett, A.C.2    Scibelli, P.3
  • 45
    • 0028167816 scopus 로고
    • Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia
    • Frisoni GB, Calabresi L, Geroldi C, et al. Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia. Dementia. 1994;5:240-242.
    • (1994) Dementia , vol.5 , pp. 240-242
    • Frisoni, G.B.1    Calabresi, L.2    Geroldi, C.3
  • 46
    • 0028113971 scopus 로고
    • The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease
    • Galasko D, Saitoh T, Xia Y, et al. The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease. Neurology. 1994;44:1950-1951.
    • (1994) Neurology , vol.44 , pp. 1950-1951
    • Galasko, D.1    Saitoh, T.2    Xia, Y.3
  • 47
    • 0029396979 scopus 로고
    • Alzheimer's disease with and without co-existing Parkinson's disease changes
    • Gearing M, Schneider JA, Rebeck GW, Hyman BT, Mirra S. Alzheimer's disease with and without co-existing Parkinson's disease changes. Neurology. 1995;45:1985-1990.
    • (1995) Neurology. , vol.45 , pp. 1985-1990
    • Gearing, M.1    Schneider, J.A.2    Rebeck, G.W.3    Hyman, B.T.4    Mirra, S.5
  • 48
    • 0028091522 scopus 로고
    • Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types
    • Harrington CR, Louwagie J, Rossau R, et al. Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Am J Pathol. 1994;145:1472-1484.
    • (1994) Am J Pathol. , vol.145 , pp. 1472-1484
    • Harrington, C.R.1    Louwagie, J.2    Rossau, R.3
  • 49
    • 0028340614 scopus 로고
    • Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus
    • Houlden H, Crook R, Hardy J, Roques P, Collinge J, Rossor M. Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus. Neurosci Lett. 1994;174:222-224.
    • (1994) Neurosci Lett. , vol.174 , pp. 222-224
    • Houlden, H.1    Crook, R.2    Hardy, J.3    Roques, P.4    Collinge, J.5    Rossor, M.6
  • 50
    • 0027997838 scopus 로고
    • Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia
    • Kawamata J, Tanaka S, Shimohama S, Ueda K, Kimura J. Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. J Neurol Neurosurg Psychiatry. 1994;57: 1414-1416.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 1414-1416
    • Kawamata, J.1    Tanaka, S.2    Shimohama, S.3    Ueda, K.4    Kimura, J.5
  • 51
    • 0028079749 scopus 로고
    • The apolipoprotein E-epsilon 4 allele is a risk factor for Alzheimer disease with early and late onset
    • Kurz A, Lautenschlager N, Haupt M, et al. The apolipoprotein E-epsilon 4 allele is a risk factor for Alzheimer disease with early and late onset. Nervenarzt. 1994;65:774-779.
    • (1994) Nervenarzt. , vol.65 , pp. 774-779
    • Kurz, A.1    Lautenschlager, N.2    Haupt, M.3
  • 52
    • 0028167740 scopus 로고
    • Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: Population based study
    • Kuusisto J, Koivisto K, Kervinen K, et al. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study. BMJ. 1994;309:636-638.
    • (1994) BMJ , vol.309 , pp. 636-638
    • Kuusisto, J.1    Koivisto, K.2    Kervinen, K.3
  • 53
    • 0028853238 scopus 로고
    • Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease
    • Lehtimaki T, Pirttila T, Mehta PD, Wisniewski HM, Frey H, Nikkari T. Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease. Hum Genet. 1995;95:39-42.
    • (1995) Hum Genet. , vol.95 , pp. 39-42
    • Lehtimaki, T.1    Pirttila, T.2    Mehta, P.D.3    Wisniewski, H.M.4    Frey, H.5    Nikkari, T.6
  • 54
    • 0028858763 scopus 로고
    • Apolipoprotein E polymorphism and Alzheimer's disease in eastern Finland
    • Lehtovirta M, Helisalmi S, Mannermaa A, et al. Apolipoprotein E polymorphism and Alzheimer's disease in eastern Finland. Neurosci Lett. 1995;185:13-15.
    • (1995) Neurosci Lett. , vol.185 , pp. 13-15
    • Lehtovirta, M.1    Helisalmi, S.2    Mannermaa, A.3
  • 55
    • 0028859880 scopus 로고
    • Apolipoprotein E genotype and Lewy body disease
    • Lippa CF, Smith TW, Saunders AM, et al. Apolipoprotein E genotype and Lewy body disease. Neurology. 1995;45:97-103.
    • (1995) Neurology , vol.45 , pp. 97-103
    • Lippa, C.F.1    Smith, T.W.2    Saunders, A.M.3
  • 56
    • 0028141602 scopus 로고
    • Association of apolipoprotein E allele ε4 with late-onset sporadic Alzheimer's disease
    • Lucotte G, Visvikis S, Leininger-Müler B, et al. Association of apolipoprotein E allele ε4 with late-onset sporadic Alzheimer's disease. Am J Med Genet. 1994;54:286-288.
    • (1994) Am J Med Genet. , vol.54 , pp. 286-288
    • Lucotte, G.1    Visvikis, S.2    Leininger-Müler, B.3
  • 59
    • 0027203749 scopus 로고
    • Apolipoprotein E genotype and Alzheimer's disease
    • Noguchi S, Murakami K, Yamada M. Apolipoprotein E genotype and Alzheimer's disease. Lancet. 1993;342:737.
    • (1993) Lancet , vol.342 , pp. 737
    • Noguchi, S.1    Murakami, K.2    Yamada, M.3
  • 60
    • 0028346903 scopus 로고
    • Apolipoprotein E4 and Alzheimer's disease pathology in Lewy body disease and in other β-amyloid-forming diseases
    • Pickering-Brown S, Mann DMA, Bourke JP, et al. Apolipoprotein E4 and Alzheimer's disease pathology in Lewy body disease and in other β-amyloid-forming diseases. Lancet. 1994;343:1155.
    • (1994) Lancet , vol.343 , pp. 1155
    • Pickering-Brown, S.1    Mann, D.M.A.2    Bourke, J.P.3
  • 61
    • 0028772164 scopus 로고
    • Protective effect of apoE ε2 in Alzheimer's disease
    • Smith AD, Johnston C, Sim E, et al. Protective effect of apoE ε2 in Alzheimer's disease. Lancet. 1994;344:473-474.
    • (1994) Lancet , vol.344 , pp. 473-474
    • Smith, A.D.1    Johnston, C.2    Sim, E.3
  • 62
    • 0029840452 scopus 로고    scopus 로고
    • Apolipoprotein-E genotyping in diagnosis of Alzheimer's disease
    • Smith AD, Jobst KA, Johnston C, Joachim C, Nagy Z. Apolipoprotein-E genotyping in diagnosis of Alzheimer's disease. Lancet. 1996;348:483-484.
    • (1996) Lancet , vol.348 , pp. 483-484
    • Smith, A.D.1    Jobst, K.A.2    Johnston, C.3    Joachim, C.4    Nagy, Z.5
  • 63
    • 0028981090 scopus 로고
    • Apolipoprotein E 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers
    • St Clair D, Rennie M, Slorach E, Norrman J, Yates C, Carothers A. Apolipoprotein E 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers. J Med Genet. 1995;32:642-644.
    • (1995) J Med Genet. , vol.32 , pp. 642-644
    • St Clair, D.1    Rennie, M.2    Slorach, E.3    Norrman, J.4    Yates, C.5    Carothers, A.6
  • 65
    • 0028301820 scopus 로고
    • Apolipoprotein E: Risk factor for Alzheimer disease
    • Tsai MS, Tangalos EG, Petersen RC, et al. Apolipoprotein E: risk factor for Alzheimer disease. Am J Hum Genet. 1994;54:643-649.
    • (1994) Am J Hum Genet. , vol.54 , pp. 643-649
    • Tsai, M.S.1    Tangalos, E.G.2    Petersen, R.C.3
  • 66
    • 0027146623 scopus 로고
    • A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease
    • Ueki A, Kawano M, Namba Y, Kawakami M, Ikeda K. A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease. Neurosci Lett. 1993;163: 166-168.
    • (1993) Neurosci Lett. , vol.163 , pp. 166-168
    • Ueki, A.1    Kawano, M.2    Namba, Y.3    Kawakami, M.4    Ikeda, K.5
  • 67
    • 0028124454 scopus 로고
    • Dose-dependent association of apolipoprotein E allele epsilon 4 with late-onset, sporadic Alzheimer's disease
    • Yoshizawa T, Yamakawa-Kobayashi K, Komatsuzaki Y, et al. Dose-dependent association of apolipoprotein E allele epsilon 4 with late-onset, sporadic Alzheimer's disease. Ann Neurol. 1994;36:656-659.
    • (1994) Ann Neurol. , vol.36 , pp. 656-659
    • Yoshizawa, T.1    Yamakawa-Kobayashi, K.2    Komatsuzaki, Y.3
  • 68
    • 0028058838 scopus 로고
    • Association of the apolipoprotein E epsilon 4 allele with clinical subtypes of autopsy-confirmed Alzheimer's disease
    • Zubenko GS, Stiffler S, Stabler S, et al. Association of the apolipoprotein E epsilon 4 allele with clinical subtypes of autopsy-confirmed Alzheimer's disease. Am J Med Genet. 1994;54:199-205.
    • (1994) Am J Med Genet. , vol.54 , pp. 199-205
    • Zubenko, G.S.1    Stiffler, S.2    Stabler, S.3
  • 70
    • 0023133252 scopus 로고
    • Apolipoprotein E isoform phenotyping methodology and population frequency with identification of APOE1 and APOE5 isoforms
    • Ordovas JM, Litwack-Klein L, Wilson PWF, Schaefer MM, Schaefer E. Apolipoprotein E isoform phenotyping methodology and population frequency with identification of APOE1 and APOE5 isoforms. J Lipid Res. 1987;28:371-380.
    • (1987) J Lipid Res. , vol.28 , pp. 371-380
    • Ordovas, J.M.1    Litwack-Klein, L.2    Wilson, P.W.F.3    Schaefer, M.M.4    Schaefer, E.5
  • 71
    • 0025801744 scopus 로고
    • Apolipoprotein E genotyping by one-stage PCR
    • Wenham PR, Price WH, Blundell G. Apolipoprotein E genotyping by one-stage PCR. Lancet. 1991;337:1158-1159.
    • (1991) Lancet , vol.337 , pp. 1158-1159
    • Wenham, P.R.1    Price, W.H.2    Blundell, G.3
  • 72
    • 0025257612 scopus 로고
    • Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal
    • Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal. J Lipid Res. 1990;31:545-548.
    • (1990) J Lipid Res. , vol.31 , pp. 545-548
    • Hixson, J.E.1    Vernier, D.T.2
  • 73
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-748.
    • (1959) J Natl Cancer Inst. , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 76
    • 0004282518 scopus 로고
    • Cary, NC: SAS Institute Inc
    • SAS Institute. SAS User's Guide: Statistics. Cary, NC: SAS Institute Inc; 1990.
    • (1990) SAS User's Guide: Statistics
  • 77
    • 0028361626 scopus 로고
    • Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type
    • Dai XY, Nanko S, Hattori M, et al. Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type. Neurosci Lett. 1994;175:74-76.
    • (1994) Neurosci Lett. , vol.175 , pp. 74-76
    • Dai, X.Y.1    Nanko, S.2    Hattori, M.3
  • 79
    • 9044228404 scopus 로고    scopus 로고
    • Risk of dementia among relatives of Alzheimer disease patients in the MIRAGE study
    • Lautenschlager NT, Cupples LA, Rao VS, et al. Risk of dementia among relatives of Alzheimer disease patients in the MIRAGE study. Neurology. 1996;46:641-650.
    • (1996) Neurology , vol.46 , pp. 641-650
    • Lautenschlager, N.T.1    Cupples, L.A.2    Rao, V.S.3
  • 80
    • 0028831614 scopus 로고
    • The apolipoprotein E ε4 allele and sex-specific risks of Alzheimer's disease
    • Corder EH, Saunders AM, Strittmatter WJ, et al. The apolipoprotein E ε4 allele and sex-specific risks of Alzheimer's disease. JAMA. 1995;273:373-374.
    • (1995) JAMA , vol.273 , pp. 373-374
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 81
    • 19244362467 scopus 로고    scopus 로고
    • Evidence for major gene inheritance of Alzheimer disease in families of patients with and without Apoe 4
    • Rao VS, Cupples LA, van Duijn CM, et al. Evidence for major gene inheritance of Alzheimer disease in families of patients with and without Apoe 4. Am J Hum Genet. 1996;59:664-675.
    • (1996) Am J Hum Genet. , vol.59 , pp. 664-675
    • Rao, V.S.1    Cupples, L.A.2    Van Duijn, C.M.3
  • 82
    • 0030591669 scopus 로고    scopus 로고
    • Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
    • Tang M-X, Jacobs D, Stern Y, et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 1996;348:429-432.
    • (1996) Lancet , vol.348 , pp. 429-432
    • Tang, M.-X.1    Jacobs, D.2    Stern, Y.3
  • 83
    • 0028286934 scopus 로고
    • Lack of association between apolipoprotein E allele 4 and sporadic Alzheimer's disease
    • Lannfelt L, Lilius L, Nastase M, et al. Lack of association between apolipoprotein E allele 4 and sporadic Alzheimer's disease. Neurosci Lett. 1994; 169:175-178.
    • (1994) Neurosci Lett. , vol.169 , pp. 175-178
    • Lannfelt, L.1    Lilius, L.2    Nastase, M.3
  • 84
    • 15844393893 scopus 로고    scopus 로고
    • Specificity, sensitivity and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease
    • Saunders AM, Hulette C, Welsh-Bohmer KA, et al. Specificity, sensitivity and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet. 1996;348:90-93.
    • (1996) Lancet , vol.348 , pp. 90-93
    • Saunders, A.M.1    Hulette, C.2    Welsh-Bohmer, K.A.3
  • 85
    • 0029840452 scopus 로고    scopus 로고
    • Apolipoprotein-E genotyping in diagnosis of Alzheimer's disease
    • Kakulas BA, Wilston SD, Fabian VA, Jones TM. Apolipoprotein-E genotyping in diagnosis of Alzheimer's disease. Lancet. 1996;348:483.
    • (1996) Lancet , vol.348 , pp. 483
    • Kakulas, B.A.1    Wilston, S.D.2    Fabian, V.A.3    Jones, T.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.