Immunosenescence of human natural killer cells

Journal of Innate Immunity

Volumn 3, Issue 4, 2011, Pages 337-343

  Gayoso, Inmaculada ^a   Sanchez Correa, Beatriz ^b   Campos, Carmen ^a   Alonso, Corona ^a   Pera, Alejandra ^a   Casado, Javier G ^b   Morgado, Sara ^b   Tarazona, Raquel ^b   Solana, Rafael ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

Aging; Cytokines; Immunosenescence; Natural killer cells, receptors

Indexed keywords

ALPHA INTERFERON; CD16 ANTIGEN; CD56 ANTIGEN; CD57 ANTIGEN; CELL SURFACE MARKER; CELL SURFACE RECEPTOR; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR NKG2A;

CELL AGING; CELL COUNT; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; CYTOTOXICITY; HUMAN; IMMUNOSENESCENCE; INNATE IMMUNITY; LYMPHOCYTE SUBPOPULATION; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SENESCENCE;

AGED; AGING; ANTIGENS, CD56; ANTIGENS, CD57; CYTOKINES; HUMANS; KILLER CELLS, NATURAL;

EID: 79959669679     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000328005     Document Type: Review

References (66)

1. Brunner S, Herndler-Brandstetter D, Weinberger B, Grubeck-Loebenstein B: Persistent viral infections and immune aging. Ageing Res Rev 2010, E-pub ahead of print.
2. Grubeck-Loebenstein B, Della BS, Iorio AM, Michel JP, Pawelec G, Solana R: Immunosenescence and vaccine failure in the elderly. Aging Clin Exp Res 2009; 21: 201-209.
3. Pawelec G, Derhovanessian E, Larbi A: Immunosenescence and cancer. Crit Rev Oncol Hematol 2010; 75: 165-172.
4. Fulop T, Kotb R, Fortin CF, Pawelec G, de Angelis F, Larbi A: Potential role of immu-nosenescence in cancer development. Ann NY Acad Sci 2010; 1197:158-165.
5. Vasto S, Candore G, Balistreri CR, Caruso M, Colonna-Romano G, Grimaldi MP, Listi F, Nuzzo D, Lio D, Caruso C: Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 2007; 128:83-91.
6. Wick G, Jansen-Durr P, Berger P, Blasko I, Grubeck-Loebenstein B: Diseases of aging. Vaccine 2000; 18: 1567-1583.
7. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G: Aging of the immune system as a prognostic factor for human longevity. Physiolog y (Bethesda) 2008; 23: 64-74.
8. DelaRosa O, Pawelec G, Peralbo E, Wikby A, Mariani E, Mocchegiani E, Tarazona R, Solana R: Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 2006; 7:471-481.
9. Pawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C, Franceschi C, Fulop T, Gupta S, Mariani E, Mocchegiani E, Solana R: T cells and aging, January 2002 update. Front Biosci 2002; 7:d1056-d1183.
10. Linton PJ, Dorshkind K: Age-related changes in lymphocyte development and function. Nat Immunol 2004; 5: 133-139.
11. Pawelec G, Solana R, Remarque E, Mariani E: Impact of aging on innate immunity. J Leukoc Biol 1998; 64:703-712.
12. Solana R, Pawelec G, Tarazona R: Aging and innate immunity. Immunity 2006; 24:491-494.
13. Parham P: Taking license with natural killer cell maturation and repertoire development. Immunol Rev 2006; 214:155-160.
14. Cooper MA, Fehniger TA, Caligiuri MA: The biology of human natural killer-cell subsets. Trends Immunol 2001; 22:633-640. (Pubitemid 33043908)
15. Farag SS, VanDeusen JB, Fehniger TA, Caligiuri MA: Biology and clinical impact of human natural killer cells. Int J Hematol 2003; 78: 7-17.
16. Wendt K, Wilk E, Buyny S, Buer J, Schmidt RE, Jacobs R: Gene and protein characteristics reflect functional diversity of CD56dim and CD56bright NK cells. J Leukoc Biol 2006; 80: 1529-1541.
17. Fauriat C, Long EO, Ljunggren HG, Bryceson YT: Regulation of human NK-cell cytokine and chemokine production by target cell recognition. Blood 2010; 115:2167-2176.
18. Berahovich RD, Lai NL, Wei Z, Lanier LL, Schall TJ: Evidence for NK cell subsets based on chemokine receptor expression. J Immunol 2006; 177:7833-7840.
19. Fehniger TA, Cooper MA, Nuovo GJ, Cella M, Facchetti F, Colonna M, Caligiuri MA: CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 2003; 101: 3052-3057.
20. Yokoyama WM, Kim S: Licensing of natural killer cells by self-major histocompatibility complex class I. Immunol Rev 2006; 214:143-154. (Pubitemid 44707908)
21. Raulet DH: Missing self recognition and self tolerance of natural killer (NK) cells. Semin Immunol 2006; 18: 145-150.
22. Kim S, Poursine-Laurent J, Truscott SM, Lybarger L, Song YJ, Yang L, French AR, Sunwoo JB, Lemieux S, Hansen TH, Yokoyama WM: Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 2005; 436: 709-713.
23. Raulet DH, Vance RE: Self-tolerance of natural killer cells. Nat Rev Immunol 2006; 6: 520-531. (Pubitemid 43980524)
24. Gasser S, Raulet DH: Activation and self-tolerance of natural killer cells. Immunol Rev 2006; 214: 130-142.
25. Bjorkstrom NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, Bjorklund AT, Flodstrom-Tullberg M, Michaelsson J, Rottenberg ME, Guzman CA, Ljunggren HG, Malmberg KJ: Expression patterns of NK-G2A, KIR, and CD57 define a process of CD56dim NK cell differentiation uncoupled from NK cell education. Blood 2010; 116: 3853-3864.
26. Lopez-Verges S, Milush JM, Pandey S, York VA, Rakawa-Hoyt J, Pircher H, Norris PJ, Nixon DF, Lanier LL: CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK cell subset. Blood 2010; 116:3865-3874.
27. Ligthart GH: The SENIEUR protocol after 16 years: the next step is to study the interaction of ageing and disease. Mech Ageing Dev 2001; 122: 136-140.
28. Ligthart GJ, Corberand JX, Geertzen HG, Meinders AE, Knook DL, Hijmans W: Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech Ageing Dev 1990; 55:89-105.
29. Borrego F, Alonso MC, Galiani MD, Carracedo J, Ramirez R, Ostos B, Pena J, Solana R: NK phenotypic markers and IL2 response in NK cells from elderly people. Exp Gerontol 1999; 34: 253-265.
30. Chidrawar SM, Khan N, Chan YL, Nayak L, Moss PA: Ageing is associated with a decline in peripheral blood CD56bright NK cells. Immun Ageing 2006; 3:10.
31. Facchini A, Mariani E, Mariani AR, Papa S, Vitale M, Manzoli FA: Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing. Clin Exp Immunol 1987; 68: 340-347.
32. Le Garff-Tavernier M, Beziat V, Decocq J, Siguret V, Gandjbakhch F, Pautas E, Debre P, Merle-Beral H, Vieillard V: Human NK cells display major phenotypic and functional changes over the life span. Aging Cell 2010; 9: 527-535.
33. Ligthart GJ, Schuit HR, Hijmans W: Natural killer cell function is not diminished in the healthy aged and is proportional to the number of NK cells in the peripheral blood. Immunology 1989; 68: 396-402.
34. Mariani E, Roda P, Mariani AR, Vitale M, Degrassi A, Papa S, Facchini A: Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis. Clin Exp Immunol 1990; 81: 479-484.
35. Sansoni P, Cossarizza A, Brianti V, Fagnoni F, Snelli G, Monti D, Marcato A, Passeri G, Ortolani C, Forti E: Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993; 82: 2767-2773.
36. Ogata K, Yokose N, Tamura H, An E, Nakamura K, Dan K, Nomura T: Natural killer cells in the late decades of human life. Clin Immunol Immunopathol 1997; 84: 269-275.
37. Ogata K, An E, Shioi Y, Nakamura K, Luo S, Yokose N, Minami S, Dan K: A ssociation between natural killer cell activity and infection in immunologically normal elderly people. Clin Exp Immunol 2001; 124: 392-397.
38. Remarque E, Pawelec G: T cell immunose-nescence and its clinical relevance in man. Rev Clin Gerontol 1998; 8:5-14.
39. Bruunsgaard H, Pedersen AN, Schroll M, Skinhoj P, Pedersen BK: Decreased natural killer cell activity is associated with atherosclerosis in elderly humans. Exp Gerontol 2001; 37: 127-136.
40. Mysliwska J, Trzonkowski P, Szmit E, Brydak LB, Machala M, Mysliwski A: Immunomod-ulating effect of influenza vaccination in the elderly differing in health status. Exp Gerontol 2004; 39:1447-1458.
41. Franceschi C, Monti D, Sansoni P, Cossarizza A: The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995; 16:12-16.
42. Sansoni P, Brianti V, Fagnoni F, Snelli G, Marcato A, Passeri G, Monti D, Cossarizza A, Franceschi C: NK cell activity and T-lymphocyte proliferation in healthy centenarians. Ann NY Acad Sci 1992; 663:505-507.
43. Ravaglia G, Forti P, Maioli F, Bastagli L, Facchini A, Mariani E, Savarino L, Sassi S, Cucinotta D, Lenaz G: Effect of micronutrient statuson natural killer cell immune function in healthy free-living subjects aged > 690 y. Am J Clin Nutr 2000; 71: 590-598.
44. Mariani E, Monaco MC, Cattini L, Sinoppi M, Facchini A: Distribution and lytic activity of NK cell subsets in the elderly. Mech Ageing Dev 1994; 76:177-187.
45. Zhang Y, Wallace DL, de Lara CM, Ghattas H, Asquith B, Worth A, Griffin GE, Taylor GP, Tough DF, Beverley PC, Macallan DC: In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection. Immunology 2007; 121: 258-265.
46. Mariani E, Meneghetti A, Formentini I, Neri S, Cattini L, Ravaglia G, Forti P, Facchini A: Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing. Exp Gerontol 2003; 38:653-659.
47. Mariani E, Meneghetti A, Formentini I, Neri S, Cattini L, Ravaglia G, Forti P, Facchini A: Telomere length and telomerase activity: effect of ageing on human NK cells. Mech Ageing Dev 2003; 124:403-408.
48. Tarazona R, DelaRosa O, Alonso C, Ostos B, Espejo J, Pena J, Solana R: Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/ senescent T cells. Mech Ageing Dev 2000; 121:77-88.
49. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA: Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003; 101:2711-2720.
50. Lanier LL: Natural killer cell receptor signaling. Curr Opin Immunol 2003; 15:308-314.
51. Lutz CT, Moore MB, Bradley S, Shelton BJ, Lutgendorf SK: Reciprocal age related change in natural killer cell receptors for MHC class I. Mech Ageing Dev 2005; 126: 722-731.
52. Solana R, Alonso MC, Pena J: Natural killer cel ls in healthy aging. Exp Gerontol 1999; 34: 435-443.
53. Solana R, Mariani E: NK and NK/T cells in human senescence. Vaccine 2000; 18: 1613 - 1620.
54. Mariani E, Ravaglia G, Meneghetti A, Tarozzi A, Forti P, Maioli F, Boschi F, Facchini A: Natural immunity and bone and muscle remodelling hormones in the elderly. Mech Ageing Dev 1998; 102: 279-292.
55. Hayhoe RP, Henson SM, Akbar AN, Palmer DB: Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset. Hum Immunol 2010; 71: 676-681.
56. Bryceson YT, Rudd E, Zheng C, Edner J, Ma D, Wood SM, Bechensteen AG, Boelens JJ, Celkan T, Farah RA, Hultenby K, Winiarski J, Roche PA, Nordenskjold M, Henter JI, Long EO, Ljunggren HG: Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lympho-histiocytosis 4 (FHL4) patients. Blood 2007; 110: 1906-1915.
57. Tarazona R, Gayoso I, Alonso C, Pita-Lopez ML, Peralbo E, Casado JG, Sanchez-Correa B, Morgado S, Solana R: NK cells in human ageing; in Fulop T, Franceschi C, Hirokawa K, Pawelec G (eds): Handbook on Immunosenescence. New York, Springer, 2009, pp 533-546.
58. Sanchez-Correa B, Gayoso I, Bergua JM, Casado JG, Morgado S, Solana R, Tarazona R: Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients. Immunol Cell Biol 2011, E-pub ahead of print.
59. Arnon TI, Achdout H, Levi O, Markel G, Saleh N, Katz G, Gazit R, Gonen-Gross T, Hanna J, Nahari E, Porgador A, Honigman A, Plachter B, Mevorach D, Wolf DG, Mandelboim O: Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Nat Immunol 2005; 6: 515-523.
60. Arnon TI, Markel G, Mandelboim O: Tumor and viral recognition by natural killer cells receptors. Semin Cancer Biol 2006; 16:348-358.
61. Kutza J, Murasko DM: Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha. Cell Immunol 1994; 155: 195-204.
62. Kutza J, Murasko DM: Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. Mech Ageing Dev 1996; 90:209-222.
63. Murasko DM, Jiang J: Response of aged mice to primary virus infections. Immunol Rev 2005; 205:285-296.
64. Mariani E, Pulsatelli L, Meneghetti A, Dolzani P, Mazzetti I, Neri S, Ravaglia G, Forti P, Facchini A: Different IL-8 production by T and NK lymphocytes in elderly subjects. Mech Ageing Dev 2001; 122: 1383-1395.
65. Mariani E, Meneghetti A, Neri S, Ravaglia G, Forti P, Cattini L, Facchini A: Chemokine production by natural killer cells from nonagenarians. Eur J Immunol 2002; 32:1524-1529.
66. Mariani E, Pulsatelli L, Neri S, Dolzani P, Meneghetti A, Silvestri T, Ravaglia G, Forti P, Cattini L, Facchini A: RANTES and MIP-1alpha production by T lymphocytes, mono-cytes and NK cells from nonagenarian subjects. Exp Gerontol 2002; 37: 219-226.