Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

Aging Cell

Volumn 11, Issue 1, 2012, Pages 104-110

  Qian, Feng ^a   Wang, Xiaomei ^a   Zhang, Lin ^a   Chen, Shu ^a   Piecychna, Marta ^a   Allore, Heather ^a   Bockenstedt, Linda ^a   Malawista, Stephen ^a   Bucala, Richard ^a   Shaw, Albert C ^a   Fikrig, Erol ^a,b   Montgomery, Ruth R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Aging; Flagellin; IL 8; Immunosenescence; Monocytes; Toll like receptors

Indexed keywords

FLAGELLIN; I KAPPA B; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MACROPHAGE MIGRATION INHIBITION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DNA BINDING; ENZYME ACTIVATION; ENZYME DEGRADATION; FEMALE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADULT; AGED; AGED, 80 AND OVER; AGING; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-8; MALE; MIDDLE AGED; MONOCYTES; MULTIVARIATE ANALYSIS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855837075     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00759.x     Document Type: Article

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