Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans

Aging Clinical and Experimental Research

Volumn 27, Issue 6, 2015, Pages 785-789

  do Nascimento, Magda Paula Pereira ^a   Pinke, Karen Henriette ^a   Penitenti, Marcimara ^b   Ikoma, Maura Rosane Valério ^b   Lara, Vanessa Soares ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Amaral Carvalho Hospital   (Brazil)

Author keywords

C. albicans; Dendritic cell; Immunosenescence; Phagocytosis and Toll like receptors

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD56 ANTIGEN; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 4; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ADULT; AGED; ARTICLE; BLOOD; CANDIDA ALBICANS; CELL MATURATION; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; FUNGAL CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; MONOCYTE; MONOCYTE DERIVED DENDRITIC CELL; NONHUMAN; NORMAL HUMAN; PHAGOCYTOSIS; RECEPTOR BLOCKING; AGING; CELL CULTURE; IMMUNITY; IMMUNOLOGY; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; AGING; CANDIDA ALBICANS; CELLS, CULTURED; DENDRITIC CELLS; HUMANS; IMMUNITY; MIDDLE AGED; MONOCYTES; PHAGOCYTOSIS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84946852061     PISSN: 15940667     EISSN: 17208319     Source Type: Journal    
DOI: 10.1007/s40520-015-0344-1     Document Type: Article

References (29)

1. Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J, Sambhara S (2004) Innate immunity in aging: impact on macrophage function. Aging Cell 4:161–167. doi:10.1111/j.1474-9728.2004.00102.x
2. Appay V, Sauce D, Prelog M (2010) The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals. Aging 2:78–81
3. Pinke KH, Calzavara C, Freitas-Faria P, Nascimento MPP, Venturini J, Lara VS (2013) Proinflammatory profile of in vitro monocytes in the ageing is affected by lymphocytes presence. Immun Ageing 10:22. doi:10.1186/1742-4933-10-22
4. Della Bella S, Bierti L, Presicce P, Arienti R, Valenti M, Saresella M, Vergani C, Villa ML (2007) Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. Clin Immunol 122:220–228
5. Gasparoto TH, Vieira NA, Porto VC, Campanelli AP, Lara VS (2009) Ageing exacerbates damage of systemic and salivary neutrophils from patients presenting Candida-related denture stomatitis. Immun Ageing 6:3
6. Gasparoto TH, Vieira NA, Porto VC, Campanelli AP, Lara VS (2011) Differences between salivary and blood neutrophils from elderly and young denture wearers. J Oral Rehabil 38:41–51
7. Gasparoto TH, de Oliveira CE, Vieira NA, Porto VC, Cunha FQ, Garlet GP, Campanelli AP, Lara VS (2012) Activation pattern of neutrophils from blood of elderly individuals with Candida-related denture stomatitis. Eur J Clin Microbiol Infect Dis 31:1271–1277
8. Ciaramella A, Spalletta G, Bizzoni F, Salani F, Caltagirone C, Bossu P (2011) Effect of age on surface molecules and cytokine expression in human dendritic cells. Cell Immunol 269:82–89
9. Asquith M, Haberthur K, Brown M, Engelmann F, Murphy A, Al-Mahdi Z, Messaoudi Ilhem (2012) Age-dependent changes in innate immune phenotype and function in rhesus macaques (Macaca mulatta). Pathobiol Aging Age Relat Dis 2:10
10. Agrawal A, Agrawal S, Gupta S (2007) Dendritic cells in human aging. Exp Gerontol 42:421–426
11. Gupta S (2014) Role of dendritic cells in innate and adaptive immune response in human aging. Exp Gerontol 54:47–52. doi:10.1016/j.exger.2013.12.009
12. Agrawal A, Sridharan A, Prakash S, Agrawal H (2012) Dendritic cells and aging: consequences for autoimmunity. Expert Rev Clin Immunol 8:73–80. doi:10.1586/eci.11.77
13. Agrawal A (2013) Mechanisms and implications of age-associated impaired innate interferon secretion by dendritic cells: a mini-review. Gerontology 59:421–426. doi:10.1159/000350536
14. Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR (2011) Dysregulation of human Toll-like receptor function in aging. Ageing Res Rev 10:346–353. doi:10.1016/j.arr.2010.10.007
15. Olivieri F, Procopio AD, Montgomery RR (2014) Effect of aging on microRNAs and regulation of pathogen recognition receptors. Curr Opin Immunol 29C:29–37. doi:10.1016/j.coi.2014.03.006
16. Chai LY, Netea MG, Vonk AG, Kullberg BJ (2009) Fungal strategies for overcoming host innate immune response. Med Mycol 47:227–236. doi:10.1080/13693780802209082
17. Ramirez-Ortiz ZG, Means TK (2012) The role of dendritic cells in the innate recognition of pathogenic fungi (A. fumigatus, C. neoformans and C. albicans). Virulence 3:635–646. doi:10.4161/viru.22295
18. Farah CS, Lynch N, McCullough MJ (2010) Oral fungal infections: an update for the general practitioner. Aust Dent J 55 Suppl 1:48–54. doi:10.1111/j.1834-7819.2010.01198.x
19. Giri S, Kindo AJ (2012) A review of Candida species causing blood stream infection. Indian J Med Microbiol 30:270–278. doi:10.4103/0255-0857.99484
20. Wenisch C, Patruta S, Daxböck F, Krause R, Hörl W (2000) Effect of age on human neutrophil function. J Leukoc Biol 67:40–45
21. Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC (2010) Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 184:2518–2527. doi:10.4049/jimmunol.0901022
22. Agrawal A, Gupta S (2011) Impact of aging on dendritic cell functions in humans. Ageing Res Rev 10:336–345. doi:10.1016/j.arr.2010.06.004
23. Nucci M, Colombo AL, Silveira F, Richtmann R, Salomão R, Branchini ML, Spector N (1998) Risk factors for death in patients with candidemia. Risk factors for death in patients with candidemia. Infect Control Hosp Epidemiol 119:846–850
24. Kauffman CA (2001) Fungal infections in older adults. Clin Infect Dis 33(4):550–555
25. Nagy I, Filkor K, Németh T, Hamari Z, Vágvolgyi C, Gácser A (2011) In vitro interactions of Candida parapsilosis wild type and lipase deficient mutants with human monocyte derived dendritic cells. BMC Microbiol 11:122
26. Netea MG, Gijzen K, Coolen N, Verschueren I, Figdor C, Van der Meer JW, Torensma R, Kullberg BJ (2004) Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages. Microbes Infect 6:985–989
27. Colonna M, Pulendran B, Iwasaki A (2006) Dendritic cells at the host–pathogen interface. Nat Immunol 7:117–120
28. You J, Dong H, Mann ER, Knight SC, Yaqoob P (2013) Ageing impairs the T cell response to dendritic cells. Immunobiology 218:1077–1084. doi:10.1016/j.imbio.2013.02.002
29. García-Rodas R, González-Camacho F, Rodríguez-Tudela JL, Cuenca-Estrella M, Zaragoza O (2011) The interaction between Candida krusei and murine macrophages results in multiple outcomes, including intracellular survival and escape from killing. Infect Immun 79:2136–2144