Interleukin-6 and C-reactive protein, successful aging, and mortality: The PolSenior study

Immunity and Ageing

Volumn 13, Issue 1, 2016, Pages

  Puzianowska Kuźnicka, Monika ^a,b   Owczarz, Magdalena ^a,c   Wieczorowska Tobis, Katarzyna ^d   Nadrowski, Pawel ^e   Chudek, Jerzy ^e   Slusarczyk, Przemyslaw ^c   Skalska, Anna ^f   Jonas, Marta ^a   Franek, Edward ^a   Mossakowska, Malgorzata ^c  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^c INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^e MEDICAL UNIVERSITY OF SILESIA   (Poland)

^f JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Aging; High sensitivity C reactive protein (CRP); Inflammaging; Interleukin 6 (IL 6); Low grade inflammation; Mortality; Successful aging; The Katz Activity of Daily Living (ADL); The Mini Mental State Examination (MMSE)

Indexed keywords

ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN;

AGED; AGING; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; DISABILITY; FEMALE; HEART INFARCTION; HUMAN; KATZ INDEX; LOW DRUG DOSE; MALE; MENTAL PERFORMANCE; MINI MENTAL STATE EXAMINATION; MORTALITY; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; SMOKING; SURVIVAL RATE; VERY ELDERLY;

EID: 84975251954     PISSN: None     EISSN: 17424933     Source Type: Journal    
DOI: 10.1186/s12979-016-0076-x     Document Type: Article

References (58)

1. Ponnappan S, Ponnappan U. Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal. 2011;14:1551-85.
2. Cevenini E, Monti D, Franceschi C. Inflamm-ageing. Curr Opin Clin Nutr Metab Care. 2013;16:14-20.
3. Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E, et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010; doi: 10.1371/journal.pone.0010667.
4. Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE. Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS One. 2011; doi: 10.1371/journal.pone.0016103.
5. Brinkley TE, Hsu FC, Beavers KM, Church TS, Goodpaster BH, Stafford RS, et al. Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach. J Gerontol A Biol Sci Med Sci. 2012;67:1099-106.
6. Hager K, Machein U, Krieger S, Platt D, Seefried G, Bauer J. Interleukin-6 and selected plasma proteins in healthy persons of different ages. Neurobiol Aging. 1994;15:771-2.
7. Roubenoff R, Harris TB, Abad LW, Wilson PW, Dallal GE, Dinarello CA. Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol A Biol Sci Med Sci. 1998;53:M20-6.
8. Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F. Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol. 2010; doi: 10.1186/1471-2172-11-30.
9. Ahmadi-Abhari S, Luben RN, Wareham NJ, Khaw KT. Distribution and determinants of C-reactive protein in the older adult population: European Prospective Investigation into Cancer-Norfolk study. Eur J Clin Invest. 2013;43:899-911.
10. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821-30.
11. Candore G, Vasto S, Colonna-Romano G, Lio D, Caruso M, Rea IM, et al. Cytokine gene polymorphisms and atherosclerosis. In: Vandenbroeck K, editor. Cytokine gene polymorphisms in multifactorial conditions. Boca Raton: CRC Press; 2006. p. 363-78.
12. Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011;12:408-15.
13. Vasan RS, Sullivan LM, Roubenoff R, Dinarello CA, Harris T, Benjamin EJ, et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation. 2003;107:1486-91.
14. Payette H, Roubenoff R, Jacques PF, Dinarello CA, Wilson PW, Abad LW, et al. Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study. J Am Geriatr Soc. 2003;51:1237-43.
15. Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jørgensen T, Pedersen BK. Predicting death from tumour necrosis factor-α and interleukin-6 in 80-year-old people. Clin Exp Immunol. 2003;132:24-31.
16. Trichopoulos D, Psaltopoulou T, Orfanos P, Trichopoulou A, Boffetta P. Plasma C-reactive protein and risk of cancer: a prospective study from Greece. Cancer Epidemiol Biomarkers Prev. 2006;15:381-4.
17. Bruunsgaard H. The clinical impact of systemic low-level inflammation in elderly populations. With special reference to cardiovascular disease, dementia and mortality. Dan Med Bull. 2006;53:285-309.
18. Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, et al. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology. 2007;68:1902-8.
19. Beyer I, Njemini R, Bautmans I, Demanet C, Bergmann P, Mets T. Inflammation-related muscle weakness and fatigue in geriatric patients. Exp Gerontol. 2012;47:52-9.
20. Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study. Mech Ageing Dev. 2012;133:456-66.
21. Jenny NS, French B, Arnold AM, Strotmeyer ES, Cushman M, Chaves PH, et al. Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars. J Gerontol A Biol Sci Med Sci. 2012;67:970-6.
22. Quaglia LA, Freitas W, Soares AA, Santos RA, Nadruz Jr W, Blaha M, et al. C-reactive protein is independently associated with coronary atherosclerosis burden among octogenarians. Aging Clin Exp Res. 2014;26:19-23.
23. Wassel CL, Barrett-Connor E, Laughlin GA. Association of circulating C-reactive protein and interleukin-6 with longevity into the 80s and 90s: The Rancho Bernardo Study. J Clin Endocrinol Metab. 2010;95:4748-55.
24. Giovannini S, Onder G, Liperoti R, Russo A, Carter C, Capoluongo E, et al. Interleukin-6, C-reactive protein, and tumor necrosis factor-α as predictors of mortality in frail, community-living elderly individuals. J Am Geriatr Soc. 2011;59:1679-85.
25. Ferrando-Martínez S, Romero-Sánchez MC, Solana R, Delgado J, de la Rosa R, Muñoz-Fernández MA, et al. Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans. Age (Dordr). 2013;35:251-9.
26. Jylhä M, Paavilainen P, Lehtimäki T, Goebeler S, Karhunen PJ, Hervonen A, et al. Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study. J Gerontol A Biol Sci Med Sci. 2007;62:1016-21.
27. Alley DE, Crimmins EM, Karlamangla A, Hu P, Seeman TE. Inflammation and rate of cognitive change in high-functioning older adults. J Gerontol A Biol Sci Med Sci. 2008;63:50-5.
28. Beleigoli AM, Boersma E, Diniz Mde F, Vidigal PG, Lima-Costa MF, Ribeiro AL. C-reactive protein and B-type natriuretic peptide yield either a non-significant or a modest incremental value to traditional risk factors in predicting long-term overall mortality in older adults. PLoS One. 2013; doi: 10.1371/journal.pone.0075809
29. Matsushima J, Kawashima T, Nabeta H, Imamura Y, Watanabe I, Mizoguchi Y, et al. Association of inflammatory biomarkers with depressive symptoms and cognitive decline in a community-dwelling healthy older sample: a 3-year follow-up study. J Affect Disord. 2015;173:9-14.
30. Bledowski P, Mossakowska M, Chudek J, Grodzicki T, Milewicz A, Szybalska A, et al. Medical, psychological and socioeconomic aspects of aging in Poland: assumptions and objectives of the PolSenior project. Exp Gerontol. 2011;46:1003-9.
31. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-98.
32. Klich-Razczka A, Piotrowicz K, Mossakowska M, Skalska A, Wizner B, Broczek K, et al. The assessment of cognitive impairment suspected of dementia in Polish elderly people: results of the population-based PolSenior Study. Exp Gerontol. 2014;57:233-42.
33. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged: The index of ADL: A standardized measure of biological and psychosocial function. JAMA. 1963;185:94-9.
34. Skalska A, Wizner B, Wiezcek A, Zdrojewski T, Chudek J, Klich-Razczka A, et al. Reduced functionality in everyday activities of patients with self-reported heart failure hospitalization--population-based study results. Int J Cardiol. 2014;176:423-9.
35. Bowling A. Aspirations for older age in the 21st century: what is successful aging? Int J Aging Hum Dev. 2007;64:263-97.
36. Eklund CM. Proinflammatory cytokines in CRP baseline regulation. Adv Clin Chem. 2009;48:111-36.
37. Salvioli S, Monti D, Lanzarini C, Conte M, Pirazzini C, Bacalini MG, et al. Immune system, cell senescence, aging and longevity - inflamm-aging reappraised. Curr Pharm Des. 2013;19:1675-9.
38. Minciullo PL, Catalano A, Mandraffino G, Casciaro M, Crucitti A, Maltese G, et al. Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity. Arch Immunol Ther Exp (Warsz). 2016;64:111-26.
39. Baylis D, Bartlett DB, Patel HP, Roberts HC. Understanding how we age: insights into inflammaging. Longev Healthspan. 2013;2:8. doi: 10.1186/2046-2395-2-8.
40. Deelen J, Beekman M, Capri M, Franceschi C, Slagboom PE. Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays. 2013;35:386-96.
41. Mekli K, Nazroo JY, Marshall AD, Kumari M, Pendleton N. Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing. Aging Clin Exp Res. 2015 Aug 7. [Epub ahead of print] doi: 10.1007/s40520-015-0419-z.
42. Dato S, Bellizzi D, Rose G, Passarino G. The impact of nutrients on the aging rate: A complex interaction of demographic, environmental and genetic factors. Mech Ageing Dev. 2016;154:49-61.
43. Akin I, Nienaber CA. "Obesity paradox" in coronary artery disease. World J Cardiol. 2015;7:603-8.
44. Brzecka A, Ejma M. Obesity paradox in the course of cerebrovascular diseases. Adv Clin Exp Med. 2015;24:379-83.
45. Kim NH, Lee J, Kim TJ, Kim NH, Choi KM, Baik SH, et al. Body Mass Index and Mortality in the General Population and in Subjects with Chronic Disease in Korea: A Nationwide Cohort Study (2002-2010). PLoS One. 2015; doi: 10.1371/journal.pone.0139924
46. Costanzo P, Cleland JG, Pellicori P, Clark AL, Hepburn D, Kilpatrick ES, et al. The obesity paradox in type 2 diabetes mellitus: relationship of body mass index to prognosis: a cohort study. Ann Intern Med. 2015;162:610-8.
47. Laird E, McNulty H, Ward M, Hoey L, McSorley E, Wallace JM, et al. Vitamin D deficiency is associated with inflammation in older Irish adults. J Clin Endocrinol Metab. 2014;99:1807-15.
48. Wood AD, Strachan AA, Thies F, Aucott LS, Reid DM, Hardcastle AC, et al. Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk. Br J Nutr. 2014;112:1341-52.
49. Oe Y, Mochizuki K, Miyauchi R, Misaki Y, Kasezawa N, Tohyama K, et al. Plasma TNF-α is associated with inflammation and nutrition status in community-dwelling Japanese elderly. J Nutr Sci Vitaminol. 2015;61:263-9.
50. Lehtimäki T, Ojala P, Rontu R, Goebeler S, Karhunen PJ, Jylhä M, et al. Interleukin-6 modulates plasma cholesterol and C-reactive protein concentrations in nonagenarians. J Am Geriatr Soc. 2005;53:1552-8.
51. Cesari M, Onder G, Zamboni V, Capoluongo E, Russo A, Bernabei R, et al. C-reactive protein and lipid parameters in older persons aged 80 years and older. J Nutr Health Aging. 2009;13:587-93.
52. Ferrara A, Barrett-Connor E, Shan J. Total, LDL, and HDL cholesterol decrease with age in older men and women. The Rancho Bernardo Study 1984-1994. Circulation. 1997;96:37-43.
53. Olszanecka-Glinianowicz M, Chudek J, Szromek A, Zahorska-Markiewicz B. Changes of systemic microinflammation after weight loss and regain - a five-year follow up study. Endokrynol Pol. 2012;63:432-8.
54. Dahlén EM, Tengblad A, Länne T, Clinchy B, Ernerudh J, Nystrom FH, et al. Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes. Diabetes Metab. 2014;40:76-81.
55. Valentine RJ, Vieira VJ, Woods JA, Evans EM. Stronger relationship between central adiposity and C-reactive protein in older women than men. Menopause. 2009;16:84-9.
56. Beavers KM, Beavers DP, Newman JJ, Anderson AM, Loeser Jr RF, Nicklas BJ, et al. Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis. Osteoarthritis Cartilage. 2015;23:249-56.
57. Varadhan R, Yao W, Matteini A, Beamer BA, Xue QL, Yang H, et al. Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults. J Gerontol A Biol Sci Med Sci. 2014;69:165-73.
58. Vaucher J, Marques-Vidal P, Waeber G, Vollenweider P. Cytokines and hs-CRP levels in individuals treated with low-dose aspirin for cardiovascular prevention: a population-based study (CoLaus Study). Cytokine. 2014;66:95-100.