B-cell diversity decreases in old age and is correlated with poor health status

Aging Cell

Volumn 8, Issue 1, 2009, Pages 18-25

  Gibson, Kate L ^a   Wu, Yu Chang ^a   Barnett, Yvonne ^b   Duggan, Orla ^b   Vaughan, Robert ^a   Kondeatis, Elli ^a   Nilsson, Bengt Olof ^c,d   Wikby, Anders ^e   Kipling, David ^f   Dunn Walters, Deborah K ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

^c RYHOV COUNTY HOSPITAL   (Sweden)

^d LINKÖPING UNIVERSITY   (Sweden)

^e JÖNKÖPING UNIVERSITY   (Sweden)

^f CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Aging; B.cells; Diversity; Elderly; Immune frailty

Indexed keywords

BIOLOGICAL MARKER; CYANOCOBALAMIN; DNA;

ADULT; AGED; AGING; ARTICLE; B LYMPHOCYTE; CELL SURVIVAL; CHROMOSOME LOSS; CONTROLLED STUDY; FRAIL ELDERLY; GENE SEQUENCE; GENETIC VARIABILITY; HEALTH STATUS; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IN VIVO STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPECTRAL KARYOTYPING;

ADULT; AGED; AGED, 80 AND OVER; AGING; B-LYMPHOCYTES; CASE-CONTROL STUDIES; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; HEALTH STATUS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 59049088629     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2008.00443.x     Document Type: Article

References (37)

1. Andrès E, Affenberger S, Zimmer J, Vinzio S, Grosu D, Pistol G, Maloisel F, Weitten T, Kaltenbach G, Blicklé JF (2006) Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin. Lab. Haematol. 28, 50-56.
2. Aydar Y, Balogh P, Tew JG, Szakal AK (2004) Follicular dendritic cells in aging, a 'bottle-neck' in the humoral immune response. Ageing Res. Rev. 3, 15-29.
3. Banerjee M, Sanderson JD, Spencer J, Dunn-Walters DK (2000) Immunohistochemical analysis of ageing human B and T cell populations reveals an age-related decline of CD8 T cells in spleen but not gut-associated lymphoid tissue (GALT). Mech. Ageing Dev. 115, 85-99.
4. Banerjee M, Mehr R, Belelovsky A, Spencer J, Dunn-Walters DK (2002) Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgV H gene hypermutation and lineage trees. Eur. J. Immunol. 32, 1947-1957.
5. Brochet X, Lefranc MP, Giudicelli V (2008) IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36, W503-W508.
6. Cancro MP (2005) B cells and aging: Gauging the interplay of generative, selective, and homeostatic events. Immunol. Rev. 205, 48-59.
7. Chong Y, Ikematsu H, Yamaji K, Nishimura M, Kashiwagi S, Hayashi J (2003) Age-related accumulation of Ig VH gene somatic mutations in peripheral B cells from aged humans. Clin. Exp. Immunol. 133, 59-66.
8. Colonna-Romano G, Aquino A, Bulati M, Aquino A, Vitello S, Lio D, Candore G, Caruso C (2006) Memory B cell subpopulations in the aged. Rejuvenation Res. 9, 149-152.
9. Crawford A, Macleod M, Schumacher T, Corlett L, Gray D (2006) Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J. Immunol. 176, 3498-3506.
10. Dace DS, Apte RS (2008) Effect of senescence on macrophage polarization and angiogenesis. Rejuvenation Res. 11, 177-185.
11. Diss TC, Peng H, Wotherspoon AC, Isaacson PG, Pan L (1993) Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J. Pathol. 169, 291-295.
12. Dunn-Walters DK, Howe CJ, Isaacson PG, Spencer J (1995) Location and sequence of rearranged immunoglobulin genes in human thymus. Eur. J. Immunol. 25, 513-519.
13. Dunn-Walters DK, Boursier L, Spencer J (1997) Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells. Eur. J. Immunol. 27, 2959-2964.
14. Effros RB, Cai Z, Linton PJ (2003) CD8 T cells and aging. Crit. Rev. Immunol. 23, 45-64.
15. Fillatreau S, Gray D, Anderton SM (2008) Not always the bad guys: B cells as regulators of autoimmune pathology. Nat. Rev. Immunol. 8, 391-397.
16. - B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 103, 2337-2342.
17. Health Protection Agency -Centre for Infections. (2008) Surveillance of Healthcare Associated Infections Report [WWW document]. URL http://www.hpa.org.uk/web/hpawebfile/hpaweb_c/1216193833496. [accessed on 20 Nov 2008].
18. Howard WA, Gibson KL, Dunn-Walters DK (2006) Antibody quality in old age. Rejuvenation Res. 9, 117-125.
19. Koch S, Solana R, Dela Rosa O, Pawelec G (2006) Human cytomegalovirus infection and T cell immunosenescence: A mini review. Mech. Ageing Dev. 127, 538-443.
20. Kolar GR, Mehta D, Wilson PC, Capra JD (2006) Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue. Scand. J. Immunol. 64, 314-324.
21. Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, Offord JR, Dispenzieri A, Katzmann JA, Melton LJ, 3rd. (2006) Prevalence of monoclonal gammopathy of undetermined significance. N. Engl. J. Med. 354, 1362-1369.
22. Lazuardi L, Jenewein B, Wolf AM, Pfister G, Tzankov A, Grubeck-Loebenstein B (2005) Age-related loss of naïve T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology 114, 37-43.
23. Ligthart GJ, Radl J, Corberand JX, Van Nieuwkoop JA, Van Staalduinen GJ, Van Helmond DJ, Hijmans W (1990) Monoclonal gammopathies in human aging: increased occurrence with age and correlation with health status. Mech Ageing Dev. 52, 235-243.
24. Lord JM, Butcher S, Killampali V, Lascelles D, Salmon M (2001) Neutrophil ageing and immunosenescence. Mech. Ageing Dev. 122, 1521-1535.
25. Macallan DC, Wallace DL, Zhang Y, Ghattas H, Asquith B, de Lara C, Worth A, Panayiotakopoulos G, Griffin GE, Tough DF, Beverley PC (2005) B-cell kinetics in humans: Rapid turnover of peripheral blood memory cells. Blood 105, 3633-3640.
26. MacLennan IC (1994) Germinal centers. Annu. Rev. Immunol. 12, 117-139.
27. Office for National Statistics (2005) Health Statistics Quarterly 26 [WWW document]. URL http://www.statistics.gov.uk/statbase/ product.asp?vlnk=6725 [accessed on 20 Nov 2008].
28. R Development Core Team (2006) R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing [WWW document]. URL http://www.r-project.org. [accessed on 20 Nov 2008].
29. Van Dijk-Hard I, Soderstrom I, Feld S, Holmberg D, Lundkvist I (1997) Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals. Eur. J. Immunol. 27, 1381-1386.
30. Wang X, Stollar BD (1999) Immunoglobulin VH gene expression in human aging. Clin. Immunol. 93, 132-142.
31. Weinberger B, Herndler-Brandstetter D, Schwanninger A, Weiskopf D, Grubeck-Loebenstein B (2008) Biology of immune responses to vaccines in elderly persons. Clin. Infect. Dis. 46, 1078-1084.
32. Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG (1998) Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: The Swedish longitudinal OCTO-immune study. Mech. Ageing Dev. 102, 187-198.
33. Wikby A, Johansson B, Olsson J, Löfgren S, Nilsson BO, Ferguson F (2002) Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 37, 445-453.
34. Wikby A, Nilsson BO, Forsey R, Thompson J, Strindhall J, Löfgren S, Ernerudh J, Pawelec G, Ferguson F, Johansson B (2006) The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech. Ageing Dev. 127, 695-704.
35. Williams GT, Jolly CJ, Kohler J, Neuberger MS (2000) The contribution of somatic hypermutation to the diversity of serum immunoglobulin: Dramatic increase with age. Immunity 13, 409-417.
36. Xue W, Luo S, Adler WH, Schulze DH, Berman JE (1997) Immunoglobulin heavy chain junctional diversity in young and aged humans. Hum. Immunol. 57, 80-92.
37. Zheng B, Han S, Takahashi Y, Kelsoe G (1997) Immunosenescence and germinal center reaction. Immunol. Rev. 160, 63-77.