Booster vaccination in the elderly: Their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titers

Vaccine

Volumn 24, Issue 47-48, 2006, Pages 6808-6811

  Kaml, Maria ^a   Weiskirchner, Ilka ^a   Keller, Michael ^a   Luft, Thomas ^a   Hoster, Eva ^b   Hasford, Joerg ^b   Young, Linda ^c   Bartlett, Bill ^d   Neuner, Christoph ^e   Fischer, Karl Heinz ^e   Neuman, Ber ^e   Würzner, Reinhard ^f   Grubeck Loebenstein, Beatrix ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b UNIVERSITY OF MUNICH   (Germany)

^c Sanofi Pasteur   (Canada)

^d SANOFI PASTEUR   (France)

^e Public Health Office   (Austria)

^f INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Aging; Immune system; Multivalent booster vaccination

Indexed keywords

DIPHTHERIA PERTUSSIS POLIOMYELITIS TETANUS VACCINE; DIPHTHERIA PERTUSSIS TETANUS VACCINE; LIVE VACCINE; POLIOMYELITIS VACCINE;

ADULT; AGED; AGING; ANTIBODY TITER; ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; VACCINATION;

ADULT; AGED; ANTIBODIES; ANTIBODY FORMATION; COHORT STUDIES; DIPHTHERIA-TETANUS-PERTUSSIS VACCINE; FEMALE; HUMANS; IMMUNIZATION, SECONDARY; MALE; POLIOVIRUS VACCINE, INACTIVATED; REGRESSION ANALYSIS; VACCINES; VACCINES, CONJUGATE;

EID: 33846402146     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.06.037     Document Type: Article

References (12)

1. Grubeck-Loebenstein B., and Wick G. The aging of the immune system. Adv Immunol 80 (2002) 243
2. Gavazzi G., and Krause K.H. Ageing and infection. Lancet Infect Dis 2 (2002) 659-666
3. Grubeck-Loebenstein B., Berger P., Saurwein-Teissl M., Zisterer K., and Wick G. No immunity for the elderly. Nat Med 4 (1998) 870
4. Hainz U., Jenewein B., Asch E., Pfeiffer K.P., Berger P., and Grubeck-Loebenstein B. Insufficient protection for healthy elderly adults by tetanus and TBE vaccines. Vaccine 23 (2005) 3232-3235
5. Hasselhorn H.M., Nubling M., Tiller F.W., and Hofmann F. Diphtheria booster immunization for adults. Dtsch Med Wochenschr 122 (1997) 281-286 [German]
6. Reuman P.D., Kubilis P., Hurni W., Brown L., and Nalin D. The effect of age and weight on the response to formalin inactivated, alum-adjuvanted hepatitis A vaccine in healthy adults. Vaccine 15 (1997) 1157-1161
7. Saurwein-Teissl M., Lung T.L., Marx F., et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 168 (2002) 5893-5899
8. ++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age. J Immunol 170 (2003) 613-619
9. Goronzy J.J., Fulbright J.W., Crowson C.S., Poland G.A., O'Fallon W.M., and Weyand C.M. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 75 (2001) 12182-12187
10. Trzonkowski P., Mysliwska J., Szmit E., et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence. Vaccine 21 (2003) 3826-3836
11. Wahid R., Cannon M.J., and Chow M. Dendritic cells and macrophages are productively infected by poliovirus. J Virol 79 (2005) 401-409
12. Wahid R., Cannon M.J., and Chow M. Virus-specific CD4+ and CD8+ cytotoxic T-cell responses and long-term T-cell memory in individuals vaccinated against polio. J Virol 79 (2005) 5988-5995