Signaling pathways in aged T cells - A reflection of T cell differentiation, cell senescence and host environment

Seminars in Immunology

Volumn 24, Issue 5, 2012, Pages 365-372

  Goronzy, Jörg J ^a,b   Li, Guangjin ^a,b   Yu, Mingcan ^a,b   Weyand, Cornelia M ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; Dual specific phosphatase; JAK STAT pathway; Signaling; T cell receptor

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CD28 ANTIGEN; CD3 ANTIGEN; CD45RA ANTIGEN; DNA DEPENDENT PROTEIN KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 6; INTERLEUKIN 7; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; PROTEIN KINASE ZAP 70; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ATAXIA TELANGIECTASIA; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CALIBRATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL AGING; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOMEOSTASIS; HUMAN; IMMUNOLOGICAL SYNAPSE; INNATE IMMUNITY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AGING; ANIMALS; CELL AGING; CELL DIFFERENTIATION; HUMANS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84868208626     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2012.04.003     Document Type: Review

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