Chimpanzees in biomedical and behavioral research: Assessing the necessity

Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity

Volumn , Issue , 2012, Pages 1-190

  Altevogt, Bruce M ^a   Pankevich, Diana E ^a   Shelton Davenport, Marilee K ^a   Kahn, Jeffrey P ^b  

^a Johns Hopkins University Berman Institute of Bioethics ^*

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84988267224     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.17226/13257     Document Type: Book

References (500)

1. Abee, C. 2011a. (Michale E. Keeling Center for Comparative Medicine and Research of the University of Texas MD Anderson Cancer Center, Bastrop, TX). Letter to Jeffrey Kahn: Chimpanzee mAb studies with attachments: Importance of chimpanzees in mAb research.pdf, Responses to IOM committee questions on mAb research with chimpanzees.pdf. September 30, 2011.
2. Abee, C. 2011b. (Michale E. Keeling Center for Comparative Medicine and Research of the University of Texas MD Anderson Cancer Center, Bastrop, TX). Email to authors: Chimpanzee studies and provision of research resources with attachments: Keeling Center from the University of Texas, KCCMR: Chimpanzee studies by year and type.pdf. July 1, 2011.
3. Abee, C. 2011c. (Michale E. Keeling Center for Comparative Medicine and Research of the University of Texas MD Anderson Cancer Center, Bastrop, TX). Email to authors: IOM chimp study-verification of numbers and ages of chimpanzees at the Michale E. Keeling Center for Comparative Medicine and Research. May 17, 2011.
4. Abee, C., M. Lammey, T. Rowell, J. VandeBerg, and S. Zola. 2011. Conference call with the directors of the Yerkes, New Iberia, Alamogordo, Southwest, and MD Anderson chimpanzee centers, Washington, DC, July 1, 2011.
5. Alnylam Pharmaceuticals. 2011. Phase 2b study of aln-rsv01 in lung transplant patients infected with respiratory syncytial virus (RSV). ClinicalTrials.gov: A service of the U.S. National Institutes of Health. http://clinicaltrials.gov/ct2/ show/NCT01065935?term=nct01065935&rank=1NLMIdentifier:NCT01065935 (accessed August 24, 2011).
6. Altaweel, L., Z. Chen, M. Moayeri, X. Cui, Y. Li, J. Su, Y. Fitz, S. Johnson, S. H. Leppla, R. Purcell, and P. Q. Eichacker. 2011. Delayed treatment with w1-mab, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice. Crit Care Med 39(6):1439-1447.
7. An, Z. 2010. Monoclonal antibodies-a proven and rapidly expanding therapeutic modality for human diseases. Protein Cell 1(4):319-330.
8. Animal Welfare Act (New Zealand). 1999. Public Act 1999, no. 142. Date of Assent 14 October 1999.
9. Australian Government National Health and Medical Research Council. 2003. Policy on the use of non-human primates for scientific purposes. http://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/ea14.pdf (accessed October 213, 2011).
10. AZA (Association of Zoos and Aquariums) Ape TAG. 2010. Chimpanzee (Pan troglodytes) care manual. Silver Spring, MD: Association of Zoos and Aquariums.
11. Bailey, J. 2008. An assessment of the role of chimpanzees in AIDS vaccine research. ALTA 36(4):381-428.
12. Bailey, J. 2010a. An assessment of the use of chimpanzees in hepatitis C research past, present and future: Validity of the chimpanzee model. ALTA 38(5):387-418.
13. Bailey, J. 2010b. An assessment of the use of chimpanzees in hepatitis C research past, present and future: 2. Alternative replacement methods. ALTA 38(6):471-494.
14. Bassett, S. E., K. M. Brasky, and R. E. Lanford. 1998. Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles. J Virol 72(4):2589-2599.
15. Bassett, S. E., D. L. Thomas, K. M. Brasky, and R. E. Lanford. 1999. Viral persistence, antibody to e1 and e2, and hypervariable region 1 sequence stability in hepatitis C virus-inoculated chimpanzees. J Virol 73(2):1118- 1126.
16. Bateson, P. 2011. Review of research using non-human primates: Report of a panel chaired by Professor Sir Patrick Bateson FRS. Medical Research Council (MRC). London, England.
17. Beck, A., T. Wurch, C. Bailly, and N. Corvaia. 2010. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev Immunol 10(5):345-352.
18. Becker, P. D., N. Legrand, C. M. van Geelen, M. Noerder, N. D. Huntington, A. Lim, E. Yasuda, S. A. Diehl, F. A. Scheeren, M. Ott, K. Weijer, H. Wedemeyer, J. P. Di Santo, T. Beaumont, C. A. Guzman, and H. Spits. 2010. Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One 5(10).
19. Bem, R. A., J. B. Domachowske, and H. F. Rosenberg. 2011. Animal models of human respiratory syncytial virus disease. Am J Physiol Lung Cell Mol Physiol 301(2):L148-L156.
20. Ben-Yehudah, A., C. A. T. Easley, B. P. Hermann, C. Castro, C. Simerly, K. E. Orwig, S. Mitalipov, and G. Schatten. 2010. Systems biology discoveries using non-human primate pluripotent stem and germ cells: Novel gene and genomic imprinting interactions as well as unique expression patterns. Stem Cell Res Ther 1(3):24.
21. Bennett, B. T., C. R. Abee, and R. Henrickson. 1995. Nonhuman primates in biomedical research. 2 vols., American College of Laboratory Animal Medicine Series. San Diego, CA: Academic Press.
22. Bettauer, R. H. 2010. Chimpanzees in hepatitis C virus research: 1998-2007. J Med Primatol 39(1):9-23.
23. Bettauer, R. H. 2011. Systematic review of chimpanzee use in monoclonal antibody research and drug development: 1981-2010. ALTEX 28(2):103- 116.
24. Bissig, K. D., S. F. Wieland, P. Tran, M. Isogawa, T. T. Le, F. V. Chisari, and I. M. Verma. 2010. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest 120(3):924- 930.
25. Blanco, J. C., M. S. Boukhvalova, K. A. Shirey, G. A. Prince, and S. N. Vogel. 2010. New insights for development of a safe and protective RSV vaccine. Hum Vaccin 6(6):482-492.
26. Boonstra, A., L. J. van der Laan, T. Vanwolleghem, and H. L. Janssen. 2009. Experimental models for hepatitis C viral infection. Hepatology 50(5):1646- 1655.
27. BPRC (Biomedical Primate Research Centre). 2011. Animal welfare: Relocation of chimpanzees. http://www.bprc.nl/BPRCE/L3/RelocChimps.html (accessed September 30, 2011).
28. Bukh, J., X. Forns, S. U. Emerson, and R. H. Purcell. 2001. Studies of hepatitis C virus in chimpanzees and their importance for vaccine development. Intervirology 44(2-3):132-142.
29. Byrd, L. G., and G. A. Prince. 1997. Animal models of respiratory syncytial virus infection. CID 25:1363-1368.
30. Carroll, S. S., S. Ludmerer, L. Handt, K. Koeplinger, N. Y. R. Zhang, D. Graham, M. E. Davies, M. MacCoss, D. Hazuda, and D. B. Olsen. 2009. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrob Agents Chemother 53(3):926-934.
31. Catanese, M. T., H. Ansuini, R. Graziani, T. Huby, M. Moreau, J. K. Ball, G. Paonessa, C. M. Rice, R. Cortese, A. Vitelli, and A. Nicosia. 2010. Role of scavenger receptor class B type in hepatitis C virus entry: Kinetics and molecular determinants. J Virol 84(1):34-43.
32. CBER (Center for Biologics Evaluation and Research) and CDER (Center for Drug Evaluation and Research). 2009. Guidance for industry. Rockville, MD: U.S. Department of Health and Human Services, Food and Drug Administration.
33. Chapman, K., N. Pullen, M. Graham, and I. Ragan. 2007. Preclinical safety testing of monoclonal antibodies: The significance of species relevance. Nat Rev Drug Discov 6(2):120-126.
34. Chapman, K., N. Pullen, L. Coney, M. Dempster, L. Andrews, J. Bajramovic, P. Baldrick, L. Buckley, A. Jacobs, G. Hale, C. Green, I. Ragan, and V. Robinson. 2009. Preclinical development of monoclonal antibodies: Considerations for the use of non-human primates. MAbs 1(5):505-516.
35. Chen, Z., P. Earl, J. Americo, I. Damon, S. K. Smith, Y. H. Zhou, F. Yu, A. Sebrell, S. Emerson, G. Cohen, R. J. Eisenberg, J. Svitel, P. Schuck, W. Satterfield, B. Moss, and R. Purcell. 2006a. Chimpanzee/human mAbs to vaccinia virus b5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus. Proc Natl Acad Sci USA 103(6):1882- 1887.
36. Chen, Z., M. Moayeri, Y. H. Zhou, S. Leppla, S. Emerson, A. Sebrell, F. Yu, J. Svitel, P. Schuck, M. St. Claire, and R. Purcell. 2006b. Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen. J Infect Dis 193(5):625-633.
37. Chen, C. M., Y. He, L. Lu, H. B. Lim, R. L. Tripathi, T. Middleton, L. E. Hernandez, D. W. Beno, M. A. Long, W. M. Kati, T. D. Bosse, D. P. Larson, R. Wagner, R. E. Lanford, W. E. Kohlbrenner, D. J. Kempf, T. J. Pilot-Matias, and A. Molla. 2007a. Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model. Antimicrob Agents Chemother 51(12):4290-4296.
38. Chen, Z., P. Earl, J. Americo, I. Damon, S. K. Smith, F. Yu, A. Sebrell, S. Emerson, G. Cohen, R. J. Eisenberg, I. Gorshkova, P. Schuck, W. Satterfield, B. Moss, and R. Purcell. 2007b. Characterization of chimpanzee/human monoclonal antibodies to vaccinia virus a33 glycoprotein and its variola virus homolog in vitro and in a vaccinia virus mouse protection model. J Virol 81(17):8989-8995.
39. Chen, Z., M. Moayeri, D. Crown, S. Emerson, I. Gorshkova, P. Schuck, S. H. Leppla, and R. H. Purcell. 2009. Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody. Infect Immun 77(9):3902-3908.
40. Chen, A. A., D. K. Thomas, L. L. Ong, R. E. Schwartz, T. R. Golub, and S. N. Bhatia. 2011a. Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci USA 108(29):11842-11847.
41. Chen, Z., K. Chumakov, E. Dragunsky, D. Kouiavskaia, M. Makiya, A. Neverov, G. Rezapkin, A. Sebrell, and R. Purcell. 2011b. Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis. J Virol 85(9):4354-4362.
42. Chen, Z., R. Schneerson, J. Lovchik, C. R. Lyons, H. Zhao, Z. Dai, J. Kubler-Kielb, S. H. Leppla, and R. H. Purcell. 2011c. Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to bacillus anthracis capsule. Proc Natl Acad Sci USA 108(2):739-744.
43. Chin, J., R. L. Magoffin, L. A. Shearer, J. H. Schieble, and E. H. Lennette. 1969. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol 89(4):449-463.
44. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244(4902):359-362.
45. Choo, Q. L., G. Kuo, R. Ralston, A. Weiner, D. Chien, G. Van Nest, J. Han, K. Berger, K. Thudium, C. Kuo et al. 1994. Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci USA 91(4):1294- 1298.
46. Cohen, J. 2007a. The endangered lab chimp. Science 315(5811):450-452.
47. Cohen, J. 2007b. NIH to end chimp breeding for research. Science 316(5829):1265.
48. CHMP (Committee for Medicinal Products for Human Use). 2011. CHMP: Overview. http://www.ema.europa.eu/ema/index.jsp?curl=pages/about_us/ general/general_content_000095.jsp&murl=menus/about_us/about_us.jsp&mid=WC0b01ac0580028c7a (accessed September 16, 2011).
49. Congress of Spain, IX Legislature. 2008. Official bulletin of the general courts (No. 19). http://www.congreso.es/public_oficiales/L9/CONG/BOCG/D/D_ 019.PDF (accessed August 23, 2011).
50. Cooper, S., A. L. Erickson, E. J. Adams, J. Kansopon, A. J. Weiner, D. Y. Chien, M. Houghton, P. Parham, and C. M. Walker. 1999. Analysis of a successful immune response against hepatitis C virus. Immunity 10(4):439-449.
51. Corballis, M. C. 2002. From hand to mouth: The origins of language. Princeton, NJ: Princeton University Press.
52. Council of Europe. 2006. Appendix A of the European convention for the protection of vertebrate animals used for experimental and other scientific purposes (ETS No. 123) guidelinges for accomodation and care of animals (article 5 of the convention) approved by the multilateral consulation. Council of Europe. Strasbourg.
53. Couto, L. B., and A. A. Kolykhalov. 2006. Animal models for HCV study. In Hepatitis C viruses: Genomes and molecular biology, edited by S.-L. Tan. Wymondham, Norfolk, UK: Horizon Bioscience.
54. Dahari, H., S. M. Feinstone, and M. E. Major. 2010. Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins. Gastroenterology 139(3):965-974.
55. de Jong, Y. P., C. M. Rice, and A. Ploss. 2010. New horizons for studying human hepatotropic infections. J Clin Invest 120(3):650-653.
56. de Marco, A. 2011. Biotechnological applications of recombinant single-domain antibody fragments. Microb Cell Fact 10:44.
57. De Vos, R., C. Verslype, E. Depla, J. Fevery, B. Van Damme, V. Desmet, and T. Roskams. 2002. Ultrastructural visualization of hepatitis C virus components in human and primate liver biopsies. J Hepatol 37(3):370-379.
58. Demarest, S. J., and S. M. Glaser. 2008. Antibody therapeutics, antibody engineering, and the merits of protein stability. Curr Opin Drug Discov Devel 11(5):675-687.
59. DeVincenzo, J., R. Lambkin-Williams, T. Wilkinson, J. Cehelsky, S. Nochur, E. Walsh, R. Meyers, J. Gollob, and A. Vaishnaw. 2010. A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proc Natl Acad Sci USA 107(19):8800- 8805.
60. DHS (U.S. Department of Homeland Security). 2007. Care and use of animals in research.. Washington, DC: U.S. Government, Management Directives System.
61. Domachowske, J. B., C. A. Bonville, and H. F. Rosenberg. 2004. Animal models for studying respiratory syncytial virus infection and its long term effects on lung function. Pediatr Infect Dis J 23(Suppl):S228-S234.
62. Dorner, M., J. A. Horwitz, J. B. Robbins, W. T. Barry, Q. Feng, K. Mu, C. T. Jones, J. W. Schoggins, M. T. Catanese, D. R. Burton, M. Law, C. M. Rice, and A. Ploss. 2011. A genetically humanized mouse model for hepatitis C virus infection. Nature 474(7350):208-211.
63. Eastwood, D., L. Findlay, S. Poole, C. Bird, M. Wadhwa, M. Moore, C. Burns, R. Thorpe, and R. Stebbings. 2010. Monoclonal antibody tgn1412 trial failure explained by species differences in cd28 expression on cd4+ effector memory T-cells. Br J Pharmacol 161(3):512-526.
64. Ehrlich, P. H., Z. A. Moustafa, K. E. Harfeldt, C. Isaacson, and L. Ostberg. 1990. Potential of primate monoclonal antibodies to substitute for human antibodies: Nucleotide sequence of chimpanzee fab fragments. Hum Antibodies Hybridomas 1(1):23-26.
65. Else, J. G. 2011. (Yerkes National Primate Research Center, Atlanta, GA). Email to authors: Chimpanzee ages with file attachment: yerkeschimpagereport.pdf. October 31, 2011.
66. EMEA (European Medicines Agency). 2008. ICH topic m3 (r2) non-clinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals. European Medincines Agency. London, England.
67. EMEA. 2011a. ICH guideline S6 (R1)-preclinical safety evaluation of biotechnology-derived pharmaceuticals. EMA/CHMP/ICH/731268/1998 European Medicines Agency.
68. EMEA. 2011b. CHMP assessment report, victrelis. http://www.ema.europa.eu/ docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/ 002332/WC500109789.pdf (accessed September 13, 2011).
69. Enard, W., M. Przeworski, S. E. Fisher, C. S. Lai, V. Wiebe, T. Kitano, A. P. Monaco, and S. Paabo. 2002. Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418(6900):869-872.
70. Erickson, A. L., Y. Kimura, S. Igarashi, J. Eichelberger, M. Houghton, J. Sidney, D. McKinney, A. Sette, A. L. Hughes, and C. M. Walker. 2001. The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes. Immunity 15(6):883-895.
71. European Communities, and Office for Official Publications. 1986. Council directive on the approximation of laws, regulations and administrative provisions of member states regarding the protection of animals used for experimental and other scientific purposes. Official Journal of the European Communities No. L 358(18. 12. 86):28 p.
72. European Parliament. 2007. Declaration of the European Parliament on primates in scientific experiments. European Parliament.
73. European Union. 2010. Directive 2010/63/EU of the European parliament and of the council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union No. L 276/33 (20. 10. 2010).
74. FDA (U.S. Food and Drug Administration). 1986. OKT3: Ortho pharmaceutical corporation: Summary basis of approval of muromonab-cd3. http://www.foiservices.com/ (accessed (September 8, 2011).
75. FDA. 2011a. Title 21-food and drugs-chapter 1-subchapter D-drugs for human use part 314 application for FDA approval to market a new drug (21CFR314). http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?cfrpart= cfrsearch.cfm?cfrpart=314&showfr=1&subpartnode=21:5.0.1.1.4.9 (accessed September 20, 2011).
76. FDA. 2011b. Title 21-food and drugs-chapter 1-subchapter F-biologics part 601 licensing (21CFR601). http://www.accessdata.fda.gov/scripts/cdrh/ cfdocs/cfcfr/CFRSearch.cfm?CFRPart=601&showFR=1&subpartNode=21: 7.0.1.1.2.8 (accessed September 20, 2011).
77. Folgori, A., S. Capone, L. Ruggeri, A. Meola, E. Sporeno, B. B. Ercole, M. Pezzanera, R. Tafi, M. Arcuri, E. Fattori, A. Lahm, A. Luzzago, A. Vitelli, S. Colloca, R. Cortese, and A. Nicosia. 2006. A T-cell HCV vaccine eliciting effective immunity against heterologous
78. Fulginiti, V. A., J. J. Eller, O. F. Sieber, J. W. Joyner, M. Minamitani, and G. Meiklejohn. 1969. Respiratory virus immunization. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine. Am J Epidemiol 89(4):435-448.
79. Galun, E., T. Burakova, M. Ketzinel, I. Lubin, E. Shezen, Y. Kahana, A. Eid, Y. Ilan, A. Rivkind, G. Pizov et al. 1995. Hepatitis C virus viremia in SCID-->BNX mouse chimera. J Infect Dis 172(1):25-30.
80. Garrone, P., A. C. Fluckiger, P. E. Mangeot, E. Gauthier, P. Dupeyrot-Lacas, J. Mancip, A. Cangialosi, I. Du Chene, R. LeGrand, I. Mangeot, D. Lavillette, B. Bellier, F. L. Cosset, F. Tangy, D. Klatzmann, and C. Dalba. 2011. A prime-boost strategy using virus-like particles pseudotyped for HCV proteins triggers broadly neutralizing antibodies in macaques. Sci Transl Med 3(94):94ra71.
81. Gewin, V. 2011. Hepatitis C mouse model a major milestone: Development paves the way for testing potential vaccines. Nature News. http://www.nature.com/ news/2011/110608/full/news.2011.356.html (accessed October 13, 2011).
82. Gibbs, R. A., J. Rogers, M. G. Katze, R. Bumgarner, G. M. Weinstock, E. R. Mardis, K. A. Remington, R. L. Strausberg, J. C. Venter, R. K. Wilson, M. A. Batzer, C. D. Bustamante, E. E. Eichler, M. W. Hahn, R. C. Hardison, K. D. Makova, W. Miller, A. Milosavljevic, R. E. Palermo, A. Siepel, J. M. Sikela, T. Attaway, S. Bell, K. E. Bernard, C. J. Buhay, M. N. Chandrabose, M. Dao, C. Davis, K. D. Delehaunty, Y. Ding, H. H. Dinh, S. Dugan-Rocha, L. A. Fulton, R. A. Gabisi, T. T. Garner, J. Godfrey, A. C. Hawes, J. Hernandez, A S. Hines, M. Holder, J. Hume, S. N. Jhangiani, V. Joshi, Z. M. Khan, E. F. Kirkness, A. Cree, R. G. Fowler, S. Lee, L. R. Lewis, Z. Li, Y. S. Liu, S. M. Moore, D. Muzny, L. V. Nazareth, D. N. Ngo, G. O. Okwuonu, G. Pai, D. Parker, H. A. Paul, C. Pfannkoch, C. S. Pohl, Y. H. Rogers, S. J. Ruiz, Sabo, J. Santibanez, B. W. Schneider, S. M. Smith, E. Sodergren, A. F. Svatek, T. R. Utterback, S. Vattathil, W. Warren, C. S. White, A. T. Chinwalla, Y. Feng, A. L. Halpern, L. W. Hillier, X. Huang, P. Minx, J. O. Nelson, K. H. Pepin, X. Qin, G. G. Sutton, E. Venter, B. P. Walenz, J. W. Wallis, K. C. Worley, S. P. Yang, S. M. Jones, M. A. Marra, M. Rocchi, J. E. Schein, R. Baertsch, L. Clarke, M. Csuros, J. Glasscock, R. A. Harris, P. Havlak, A. R. Jackson, H. Jiang, Y. Liu, D. N. Messina, Y. Shen, H. X. Song, T. Wylie, L. Zhang, E. Birney, K. Han, M. K. Konkel, J. Lee, A. F. Smit, B. Ullmer, H. Wang, J. Xing, R. Burhans, Z. Cheng, J. E. Karro, J. Ma, B. Raney, X. She, M. J. Cox, J. P. Demuth, L. J. Dumas, S. G. Han, J. Hopkins, A. Karimpour-Fard, Y. H. Kim, J. R. Pollack, T. Vinar, C. Addo-Quaye, J. Degenhardt, A. Denby, M. J. Hubisz, A. Indap, C. Kosiol, B. T. Lahn, H. A. Lawson, A. Marklein, R. Nielsen, E. J. Vallender, A. G. Clark, B. Ferguson, R. D. Hernandez, K. Hirani, H. Kehrer-Sawatzki, J. Kolb, S. Patil, L. L. Pu, Y. Ren, D. G. Smith, D. A. Wheeler, I. Schenck, E. V. Ball, R. Chen, D. N. Cooper, B. Giardine, F. Hsu, W. J. Kent, A. Lesk, D. L. Nelson, E. O'Brien W. K. Prufer, P. D. Stenson, J. C. Wallace, H. Ke, X. M. Liu, P. Wang, A. P. Xiang, F. Yang, G. P. Barber, D. Haussler, D. Karolchik, A. D. Kern, R. M. Kuhn, K. E. Smith, and A. S. Zwieg. 2007. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316(5822):222-234.
83. GlaxoSmithKline. 2011. Use of non-human primates (NHPs) in the discovery and development of medicines and vaccines. http://www.gsk.com/policies/GSKpublic- position-on-NHP.pdf (accessed July 27, 2011).
84. Goncalvez, A. P., R. Men, C. Wernly, R. H. Purcell, and C. J. Lai. 2004a. Chimpanzee fab fragments and a derived humanized immunoglobulin g1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses. J Virol 78(23):12910-12918.
85. Goncalvez, A. P., R. H. Purcell, and C. J. Lai. 2004b. Epitope determinants of a chimpanzee fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoprotein. J Virol 78(23):12919-12928.
86. Goncalvez, A. P., R. E. Engle, M. St. Claire, R. H. Purcell, and C. J. Lai. 2007. Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention. Proc Natl Acad Sci USA 104(22):9422-9427.
87. Goncalvez, A. P., C. H. Chien, K. Tubthong, I. Gorshkova, C. Roll, O. Donau, P. Schuck, S. Yoksan, S. D. Wang, R. H. Purcell, and C. J. Lai. 2008. Humanized monoclonal antibodies derived from chimpanzee fabs protect against Japanese encephalitis virus in vitro and in vivo. J Virol 82(14):7009- 7021.
88. Graham, B. S. 2011. Biological challenges and technological opportunities for respiratory syncytial virus vaccine development. Immunol Rev 239(1):149- 166.
89. Halliday, J., P. Klenerman, and E. Barnes. 2011. Vaccination for hepatitis C virus: Closing in on an evasive target. Expert Rev Vaccines 10(5):659-672.
90. Harcourt, J. L., H. Caidi, L. J. Anderson, and L. M. Haynes. 2011. Evaluation of the calu-3 cell line as a model of in vitro respiratory syncytial virus infection. J Virol Methods 174(1-2):144-149.
91. Hartung, T. 2010. Comparative analysis of the revised directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC-a T4 report. ALTEX 27(4):285-303.
92. HHS (U.S. Department of Health and Human Services). 2005. Code of Federal Regulations title 45 public welfare. Washington, DC: U.S. National Institutes of Health, Office of Human Subjects Research.
93. HHS. 2011a. Costs for maintaining humane care and welfare of chimpanzees. http://grants.nih.gov/grants/policy/air/cost_for_caring_housing_of_chimpan zees_20110609.htm (accessed July 20, 2011).
94. HHS. 2011b. NIH statement on the Alamogordo Primate Facility chimpanzees. http://grants.nih.gov/grants/policy/air/nih_alamogordo_statement_20110104. htm (accessed September 9, 2011).
95. HHS. 2011c. Operation and maintenance of a chimpanzee facility: NHLBI-csb- (rr)-ss-2011-264-kjm. https://www.fbo.gov/spg/HHS/NIH/OAM/NHLBI-CSB- (RR)-SS-2011-264-KJM/listing.html (accessed August 24, 2011).
96. HHS. 2011d. Response to the Physicians Committee for Responsible Medicine petition for administrative action April 8, 2011. http://grants.nih.gov/grants/ policy/air/physicians_committee_response_20110408.htm (accessed October 20, 2011).
97. Horner, V., J. D. Carter, M. Suchak, and F. B. de Waal. 2011. Spontaneous prosocial choice by chimpanzees. Proc Natl Acad Sci USA 108(33):13847- 13851.
98. Hosea, N. A. 2011. Drug design tools-in silico, in vitro and in vivo ADME/PK prediction and interpretation: Is PK in monkey an essential part of a good human PK prediction? Curr Top Med Chem 11(4):351-357.
99. Houghton, M. 2011. Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses. Immunol Rev 239(1):99-108.
100. Houghton, M., and S. Abrignani. 2005. Prospects for a vaccine against the hepatitis C virus. Nature 436(7053):961-966.
101. The Humane Society of the United States. 2010. The HSUS urges Department of Health and Human Services to retire 202 chimpanzees. Press release, August 18. Gaithersburg, MD: The Humane Society of the United States.
102. ICH Harmonized Tripartite Guideline. 2011. Preclinical safety evaluation of biotechnology derived pharmaceuticals S6(R1). http://www.ich.org/fileadmin/ Public_Web_Site/ICH_Products/Guidelines/Safety/S6_R1/Step4/S6_R1_Guide line.pdf (accessed October 13, 2011).
103. Ilyas, J. A., and J. M. Vierling. 2011. An overview of emerging therapies for the treatment of chronic hepatitis C. Clin Liver Dis 15(3):515-536.
104. Ings, R. M. 2009. Microdosing: A valuable tool for accelerating drug development and the role of bioanalytical methods in meeting the challenge. Bioanalysis 1(7):1293-1305.
105. Iwarson, S., E. Tabor, H. C. Thomas, A. Goodall, J. Waters, P. Snoy, J. W. Shih, and R. J. Gerety. 1985. Neutralization of hepatitis B virus infectivity by a murine monoclonal antibody: An experimental study in the chimpanzee. J Med Virol 16(1):89-96.
106. Jacobson, I. M., J. G. McHutchison, G. Dusheiko, A. M. Di Bisceglie, K. R. Reddy, N. H. Bzowej, P. Marcellin, A. J. Muir, P. Ferenci, R. Flisiak, J. George, M. Rizzetto, D. Shouval, R. Sola, R. A. Terg, E. M. Yoshida, N. Adda, L. Bengtsson, A. J. Sankoh, T. L. Kieffer, S. George, R. S. Kauffman, and S. Zeuzem. 2011. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 364(25):2405-2416.
107. Jensen, D. M. 2011. A new era of hepatitis C therapy begins. N Engl J Med 364(13):1272-1274.
108. Kapoor, A., P. Simmonds, G. Gerold, N. Qaisar, K. Jain, J. A. Henriquez, C. Firth, D. L. Hirschberg, C. M. Rice, S. Shields, and W. I. Lipkin. 2011. Characterization of a canine homolog of hepatitis C virus. Proc Natl Acad Sci USA 108(28):11608-11613.
109. Kingstone, A., C. K. Friesen, and M. S. Gazzaniga. 2000. Reflexive joint attention depends on lateralized cortical connections. Psychol Sci 11(2):159-166.
110. Klevens, R. M., and R. A. Tohme. 2010. Evaluation of acute hepatitis C infection surveillance-United States, 2008. MMWR 59(43):4.
111. Kneteman, N. M., and D. F. Mercer. 2005. Mice with chimeric human livers: Who says supermodels have to be tall? Hepatology 41(4):703-706.
112. Köhler, G., and C. Milstein. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517):495-497.
113. Konopka, G., J. M. Bomar, K. Winden, G. Coppola, Z. O. Jonsson, F. Gao, S. Peng, T. M. Preuss, J. A. Wohlschlegel, and D. H. Geschwind. 2009. Humanspecific transcriptional regulation of CNS development genes by FOXP2. Nature 462(7270):213-217.
114. Korte, T. 2010. Chimps' future prompts debate over NM primate lab. Associated Press Online. September 22.
115. Krilov, L. R. 2011. Respiratory syncytial virus disease: Update on treatment and prevention. Expert Rev Anti Infect Ther 9(1):27-32.
116. Kurosaki, M., N. Enomoto, F. Marumo, and C. Sato. 1993. Rapid sequence variation of the hypervariable region of hepatitis C virus during the course of chronic infection. Hepatology 18(6):1293-1299.
117. Kwo, P. Y., E. J. Lawitz, J. McCone, E. R. Schiff, J. M. Vierling, D. Pound, M. N. Davis, J. S. Galati, S. C. Gordon, N. Ravendhran, L. Rossaro, F. H. Anderson, I. M. Jacobson, R. Rubin, K. Koury, L. D. Pedicone, C. A. Brass, E. Chaudhri, and J. K. Albrecht. 2010. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (sprint-1): An open-label, randomised, multicentre phase 2 trial. Lancet 376(9742):705-716.
118. Lai, C. S., S. E. Fisher, J. A. Hurst, F. Vargha-Khadem, and A. P. Monaco. 2001. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413(6855):519-523.
119. Lammey, M. 2011. (Alamogordo Primate Facility, Alamogordo, NM). Email to authors: IOM chimp study with file attachment: APF colony age sex breakdown.xls. May 17, 2011.
120. Landry, J. 2011. (New Iberia Research Center, New Iberia, LA). Email to authors: IOM chimp study with file attachment: NIRC chimps count by age.xls. May 17, 2011.
121. Lanford, R. E., B. Guerra, C. B. Bigger, H. Lee, D. Chavez, and K. M. Brasky. 2007. Lack of response to exogenous interferon-alpha in the liver of chimpanzees chronically infected with hepatitis C virus. Hepatology 46(4):999-1008.
122. Lanford, R., B. Guerra, D. Chavez, V. L. Hodara, X. Zheng, G. Wolfgang, and D. B. Tumas. 2011. Therapeutic efficacy of a TLR7 agonist for HBV chronic infection in chimpanzees. Paper presented at 46th Annual Meeting of the European Association for the Study of the Liver, Berlin, Germany, March 30-April 3.
123. Langford, R. E. 2011. (Texas Biomedical Research Institute, San Antonio, TX). Email to authors: Chimpanzee data from SNPRC for IOM committee with file attachment: SNPRC chimpanzee studies and biomaterials IOM 62811.pdf. June 29, 2011.
124. Ledford, H. 2010. Chimps' fate ignites debate. Nature 467(7315):507-508.
125. Lindenbach, B. D., M. J. Evans, A. J. Syder, B. Wolk, T. L. Tellinghuisen, C. C. Liu, T. Maruyama, R. O. Hynes, D. R. Burton, J. A. McKeating, and C. M. Rice. 2005. Complete replication of hepatitis C virus in cell culture. Science 309(5734):623-626.
126. Lohmann, V., F. Korner, J. Koch, U. Herian, L. Theilmann, and R. Bartenschlager. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285(5424):110-113.
127. Ma, Y., L. Poisson, G. Sanchez-Schmitz, S. Pawar, C. Qu, G. J. Randolph, W. L. Warren, E. M. Mishkin, and R. G. Higbee. 2010. Assessing the immunopotency of toll-like receptor agonists in an in vitro tissueengineered immunological model. Immunology 130(3):374-387.
128. MacDermot, K. D., E. Bonora, N. Sykes, A. M. Coupe, C. S. Lai, S. C. Vernes, F. Vargha-Khadem, F. McKenzie, R. L. Smith, A. P. Monaco, and S. E. Fisher. 2005. Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. Am J Hum Genet 76(6):1074-1080.
129. Maher, L., B. White, M. Hellard, A. Madden, M. Prins, T. Kerr, and K. Page. 2010. Candidate hepatitis C vaccine trials and people who inject drugs: Challenges and opportunities. Vaccine 28(45):7273-7278.
130. Marasco, W. A., and J. Sui. 2007. The growth and potential of human antiviral monoclonal antibody therapeutics. Nat Biotechnol 25(12):1421-1434.
131. Marques-Bonet, T., O. A. Ryder, and E. E. Eichler. 2009. Sequencing primate genomes: What have we learned? Annu Rev Genomics Hum Genet 10:355- 386.
132. MedImmune LLC. 2011a. A randomized, double-blind, placebo-controlled study to evaluate viral shedding of medi-559 in healthy 1 to <24 month-old children. ClinicalTrials.gov: A service of the U.S. National Institutes of Health. http://clinicaltrials.gov/ct2/show/NCT00767416?term=NCT00767416&rank= 1 NLM Idenitifier: NCT00767416 (accessed August 24, 2011).
133. MedImmune LLC. 2011b. A study to evaluate the safety, tolerability, immunogenicity and vaccine-like viral shedding of MEDIi-534, against respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3), in healthy 6 to <24 month-old children and in 2 month-old infants. ClinicalTrials.gov: A service of the U.S. National Institutes of Health. http://clinicaltrials.gov/ct2/show/NCT00686075?term=NCT00686075&rank= 1 NLM Identifier: NCT00686075 (accessed August 24, 2011).
134. Men, R., T. Yamashiro, A. P. Goncalvez, C. Wernly, D. J. Schofield, S. U. Emerson, R. H. Purcell, and C. J. Lai. 2004. Identification of chimpanzee fab fragments by repertoire cloning and production of a full-length humanized immunoglobulin g1 antibody that is highly efficient for neutralization of dengue type 4 virus. J Virol 78(9):4665-4674.
135. Mercer, D. F., D. E. Schiller, J. F. Elliott, D. N. Douglas, C. Hao, A. Rinfret, W. R. Addison, K. P. Fischer, T. A. Churchill, J. R. Lakey, D. L. Tyrrell, and N. M. Kneteman. 2001. Hepatitis C virus replication in mice with chimeric human livers. Nat Med 7(8):927-933.
136. Meuleman, P., L. Libbrecht, R. De Vos, B. de Hemptinne, K. Gevaert, J. Vandekerckhove, T. Roskams, and G. Leroux-Roels. 2005. Morphological and biochemical characterization of a human liver in a UPA-SCID mouse chimera. Hepatology 41(4):847-856.
137. Meunier, J. C., J. M. Gottwein, M. Houghton, R. S. Russell, S. U. Emerson, J. Bukh, and R. H. Purcell. 2011. Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus. J Infect Dis 204(8):1186- 1190.
138. MicroDose Therapeutx. 2011. A trial to assess the safety, tolerability, and pharmacokinetics of MDT-637 in healthy volunteers. ClinicalTrials.gov: A service of the U.S. National Institutes of Health. http://clinicaltrials.gov/ ct2/show/NCT01355016?term=nct01355016&rank=1. NLM Identifier: NCT01355016 (accessed August 24, 2011).
139. Mikkelsen, T. S., L. W. Hillier, E. E. Eichler, M. C. Zody, D. B. Jaffe, S.-P. Yang, W. Enard, I. Hellmann, K. Lindblad-Toh, T. K. Altheide, N. Archidiacono, P. Bork, J. Butler, J. L. Chang, Z. Cheng, A. T. Chinwalla, P. deJong, K. D. Delehaunty, C. C. Fronick, L. L. Fulton, Y. Gilad, G. Glusman, S. Gnerre, T. A. Graves, T. Hayakawa, K. E. Hayden, X. Huang, H. Ji, W.J. Kent, M.-C. King, E. J. Kulbokas III, M. K. Lee, G. Liu, C. Lopez-Otin, K. D. Makova, O. Man, E. R. Mardis, E. Mauceli, T. L. Miner, W. E. Nash, J. O. Nelson, S. Pääbo, N. J. Patterson, C. S. Pohl, K. S. Pollard, K. Prüfer, X. S. Puente, D. Reich, M. Rocchi, K. Rosenbloom, M. Ruvolo, D. J. Richter, S. F. Schaffner, A. F. A. Smit, S. M. Smith, M. Suyama, J. Taylor, D. Torrents, E. Tuzun, A. Varki, G. Velasco, M. Ventura, J. W. Wallis, M. C. Wendl, R. K. Wilson, E. S. Lander, and R. H. Waterston. 2005. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437(7055):69-87.
140. Mohapatra, S. S., and S. Boyapalle. 2008. Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma. Clin Microbiol Rev 21(3):495-504.
141. Muller, P. Y., M. Milton, P. Lloyd, J. Sims, and F. R. Brennan. 2009. The minimum anticipated biological effect level (MABEL) for selection of first human dose in clinical trials with monoclonal antibodies. Curr Opin Biotechnol 20(6):722-729.
142. Mundy, P., M. Gwaltney, and H. Henderson. 2010. Self-referenced processing, neurodevelopment and joint attention in autism. Autism 14(5):408-429.
143. Murphy, B. R., S. L. Hall, J. Crowe, P. L. Collins, E. K. Subbarao, M. Connors, W. T. London, and R. M. Chanock. 1992. The use of chimpanzees in respiratory virus research. In Chimpanzee conservation and public health: Environments for the future, 1st ed., edited by J. Erwin and J. C. Landon. Rockville, MD: Diagnon Corp./Bioqual. Pp. 21-27.
144. Nair, H., V. R. Verma, E. Theodoratou, L. Zgaga, T. Huda, E. A. Simoes, P. F. Wright, I. Rudan, and H. Campbell. 2011. An evaluation of the emerging interventions against respiratory syncytial virus (RSV)-associated acute lower respiratory infections in children. BMC Public Health 11(Suppl 3):S30.
145. NCRR (National Center for Research Resources). 2007. Report of the chimpanzee management plan working group. http://ncrr.nih.gov/comparative_medicine/chimpanzee_management_program/ChimP05-22-2007.pdf (accessed July 27, 2011).
146. NCRR. 2011a. Primate resources. http://www.ncrr.nih.gov/comparative_ medicine/resource:directory/primates.asp#alamo (accessed July 27, 2011).
147. NCRR. 2011b. Chimpanzee management program. http://www.ncrr.nih.gov/ comparative_medicine/chimpanzee_mangementprogram/ (accessed July 27, 2011).
148. Nelson, A. L., E. Dhimolea, and J. M. Reichert. 2010. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 9(10):767- 774.
149. NIAID (U.S. National Institute of Allergy and Infectious Diseases). 2011. Emerging and re-emerging infectious diseases. http://www.niaid.nih.gov/ topics/emerging/Pages/list.aspx (accessed August 18, 2011).
150. NIH. 2011. About NIH: Mission. http://nih.gov/about/mission.htm (accessed August 13, 2011).
151. NIH (U.S. National Institutes of Health). Unpublished. Charter of the interagency animal model committee.
152. Novavax. 2011. Safety study of respiratory syncytial virus F (RSV-F) vaccine to treat the respiratory syncytial virus in healthy adults 18 to 49 years of age (nvx 757 101). ClinicalTrials.gov: A service of the U.S. National Institute of Health. http://clinicaltrials.gov/ct2/show/NCT01290419?term=NCT01290419 NCT01290419&rank=1 NLM Identifier: NCT01290419 (accessed August 2, 2011).
153. NRC (National Research Council). 1997. Chimpanzees in research: Strategies for their ethical care, management, and use. Washington, DC: National Academy Press.
154. NRC. 2010. Guide for the care and use of laboratory animals, 8th ed. Washington, DC: The National Academies Press.
155. NSF (National Science Foundation). 2011. Funding search results. http://www.nsf.gov/funding/funding_results.jsp?nsfOrgs=allorg&pubStatus =ACTIVE&queryText=chimpanzee&searchAwards=on&submit.x=0&sub mit.y=0 (accessed July 14, 2011).
156. Okasha, S. 2010. Altruism researchers must cooperate. Nature 467(7316):653- 655.
157. Olsen, D. B., M. E. Davies, L. Handt, K. Koeplinger, N. R. Zhang, S. W. Ludmerer, D. Graham, N. Liverton, M. MacCoss, D. Hazuda, and S. S. Carroll. 2011. Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents. Antimicrob Agents Chemother 55(2):937-939.
158. Pan, C. H., C. E. Greer, D. Hauer, H. S. Legg, E. Y. Lee, M. J. Bergen, B. Lau, R. J. Adams, J. M. Polo, and D. E. Griffin. 2010. A chimeric alphavirus replicon particle vaccine expressing the hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques from measles. J Virol 84(8):3798-3807.
159. Parliament of the United Kingdom. 1987. Guidance on the Operation of the Animals (Scientific Procedures) Act 1986. On January 1, 1997. Act Eliz. II 1986 C.14 Section 21. United Kingdom.
160. Pharmaceutical Business Review. 2011. Search of clinical trials for preclinical RSV programs in development for either therapeutics or prophylactics. http://clinicaltrials.pharmaceutical-business-review.com (accessed August 24, 2011).
161. Physicians Committee for Responsible Medicine. 2011. Petition for administrative action before the National Institutes of Health, submitted to: Francis S. Collins, Director, National Institutes of Health, March 3.
162. Ploss, A., and C. M. Rice. 2009. Towards a small animal model for hepatitis C. EMBO Rep 10(11):1220-1227.
163. Pollack, P., and J. R. Groothuis. 2002. Development and use of palivizumab (synagis): A passive immunoprophylactic agent for RSV. J Infect Chemother 8(3):201-206.
164. Prescott, W. A., Jr., F. Doloresco, J. Brown, and J. A. Paladino. 2010. Cost effectiveness of respiratory syncytial virus prophylaxis: A critical and systematic review. Pharmacoeconomics 28(4):279-293.
165. Qiu, J., B. Qin, S. Rayner, C. C. Wu, R. J. Pei, S. Xu, Y. Wang, and X. W. Chen. 2011. Novel evidence suggests hepatitis B virus surface proteins participate in regulation of HBV genome replication. Virol Sin 26(2):131-138.
166. Reichert, J. M., C. J. Rosensweig, L. B. Faden, and M. C. Dewitz. 2005. Monoclonal antibody successes in the clinic. Nat Biotechnol 23(9):1073- 1078.
167. Reynolds, J., and CEECE (Coalition to End Experiments on Chimpanzees in Europe). 2001. Report on the Biomedical Primate Research Centre (BPRC). Brighton, UK: CEECE.
168. Reynolds, T. 2011. Monoclonal antibody therapeutics [slide presentation]. Presented to the Committee on the Use of Chimpanzees in Biomedical and Behavioral Research, August 11, 2011, Washington, DC.
169. Rowell, T. J. 2011. (New Iberia Research Center, New Iberia, LA). Email to authors: Chimpanzee data from NIRC for IOM committee with file attachment: studies and bio requests.pdf. June 30, 2011.
170. Sakai, T., A. Mikami, M. Tomonaga, M. Matsui, J. Suzuki, Y. Hamada, M. Tanaka, T. Miyabe-Nishiwaki, H. Makishima, M. Nakatsukasa, and T. Matsuzawa. 2011. Differential prefrontal white matter development in chimpanzees and humans. Curr Biol 21(16):1397-1402.
171. SCHER (Scientific Committee on Health and Environmental Risks). 2009. The need for non-human primates in biomedical research, production and testing of products and devices. Adopted at the 27th plenary on 13 January 2009. European Commission, Health and Protection Consumer Directorate- General. Brussels.
172. Schofield, D. J., J. Glamann, S. U. Emerson, and R. H. Purcell. 2000. Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein. J Virol 74(12):5548-5555.
173. Schofield, D. J., W. Satterfield, S. U. Emerson, and R. H. Purcell. 2002. Four chimpanzee monoclonal antibodies isolated by phage display neutralize hepatitis A virus. Virology 292(1):127-136.
174. Schofield, D. J., R. H. Purcell, H. T. Nguyen, and S. U. Emerson. 2003. Monoclonal antibodies that neutralize HEVrecognize an antigenic site at the carboxyterminus of an ORF2 protein vaccine. Vaccine 22(2):257-267.
175. Secretary of State for the Home Department and Parliament of the United Kingdom. 1998. Report of the Animal Procedures Committee for 1997. London, UK: Secretary of State for the Home Department and Parliament.
176. Shadman, K. A., and E. R. Wald. 2011. A review of palivizumab and emerging therapies for respiratory syncytial virus. Expert Opin Biol Ther, http://www.ncbi.nlm.nih.gov/pubmed/21831008 (accessed August 11, 2011).
177. Shah, J. N., and R. F. Chemaly. 2011. Management of RSV infections in adult recipients of hematopoietic stem cell transplantation. Blood 117(10):2755- 2763.
178. Sheehy, P., B. Mullan, I. Moreau, E. Kenny-Walsh, F. Shanahan, M. Scallan, and L. J. Fanning. 2007. In vitro replication models for the hepatitis C virus. J Viral Hepat 14(1):2-10.
179. Shoukry, N. H., A. Grakoui, M. Houghton, D. Y. Chien, J. Ghrayeb, K. A. Reimann, and C. M. Walker. 2003. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 197(12):1645-1655.
180. Strickland, G. T., S. S. El-Kamary, P. Klenerman, and A. Nicosia. 2008. Hepatitis C vaccine: Supply and demand. Lancet Infect Dis 8(6):379-386.
181. Su, A. I., J. P. Pezacki, L. Wodicka, A. D. Brideau, L. Supekova, R. Thimme, S. Wieland, J. Bukh, R. H. Purcell, P. G. Schultz, and F. V. Chisari. 2002. Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci USA 99(24):15669-15674.
182. Suomi, S. J. 2006. Risk, resilience, and gene X environment interactions in rhesus monkeys. Ann N Y Acad Sci 1094:52-62.
183. Tabrizi, M. A., G. G. Bornstein, S. L. Klakamp, A. Drake, R. Knight, and L. Roskos. 2009. Translational strategies for development of monoclonal antibodies from discovery to the clinic. Drug Discov Today 14(5-6):298- 305.
184. Taglialatela, J. P., J. L. Russell, J. A. Schaeffer, and W. D. Hopkins. 2008. Communicative signaling activates "Broca's" homolog in chimpanzees. Curr Biol 18(5):343-348.
185. Tayyari, F., D. Marchant, T. J. Moraes, W. Duan, P. Mastrangelo, and R. G. Hegele. 2011. Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Nat Med 17(9):1132-1135.
186. Thimme, R., J. Bukh, H. C. Spangenberg, S. Wieland, J. Pemberton, C. Steiger, S. Govindarajan, R. H. Purcell, and F. V. Chisari. 2002. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci USA 99(24):15661-15668.
187. Thomson, M., M. Nascimbeni, M. B. Havert, M. Major, S. Gonzales, H. Alter, S. M. Feinstone, K. K. Murthy, B. Rehermann, and T. J. Liang. 2003. The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity. J Virol 77(2):862-870.
188. U.S. Office of Laboratory Animal Welfare. 2002. Public Health Service policy on humane care and use of laboratory animals. http://grants.nih.gov/grants/ http://grants.nih.gov/grants/olaw/references/phspol.htm (accessed August 18, 2011).
189. Valenzuela, D. M., A. J. Murphy, D. Frendewey, N. W. Gale, A. N. Economides, W. Auerbach, W. T. Poueymirou, N. C. Adams, J. Rojas, J. Yasenchak, R. Chernomorsky, M. Boucher, A. L. Elsasser, L. Esau, J. Zheng, J. A. Griffiths, X. Wang, H. Su, Y. Xue, M. G. Dominguez, I. Noguera, R. Torres, L. E. Macdonald, A. F. Stewart, T. M. DeChiara, and G. D. Yancopoulos. 2003. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21(6):652-659.
190. Valerio, L. G., Jr. 2011. In silico toxicology models and databases as FDA Critical Path Initiative toolkits. Hum Genomics 5(3):200-207.
191. Verstrepen, B. E., E. Depla, C. S. Rollier, G. Mares, J. A. Drexhage, S. Priem, E. J. Verschoor, G. Koopman, C. Granier, M. Dreux, F. L. Cosset, G. Maertens, and J. L. Heeney. 2011. Clearance of genotype 1B hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies. J Infect Dis 204(6):837-844.
192. Vertex Pharmaceuticals Incorporated. 2011. Telaprevir 375-mg film-coated tablet for the treatment of genotype 1 chronic hepatitis C. hhtp://www.fda.gov/down loads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AntiviralDrugs AdvisoryCommittee/UCM252562.pdf (accessed September 13, 2011).
193. Vogel, G. 2001. Dutch end chimp studies. ScienceNOW. http://news.sciencemag. http://news.sciencemag.org/sciencenow/2001/05/01-01.html (accessed September 30, 2011).
194. Wang, C. C., E. Krantz, J. Klarquist, M. Krows, L. McBride, E. P. Scott, T. Shaw-Stiffel, S. J. Weston, H. Thiede, A. Wald, and H. R. Rosen. 2007. Acute hepatitis C in a contemporary U.S. cohort: Modes of acquisition and factors influencing viral clearance. J Infect Dis 196(10):1474-1482.
195. Waterston, R. H., K. Lindblad-Toh, E. Birney, J. Rogers, J. F. Abril, P. Agarwal, R. Agarwala, R. Ainscough, M. Alexandersson, P. An, S. E. Antonarakis, J. Attwood, R. Baertsch, J. Bailey, K. Barlow, S. Beck, E. Berry, B. Birren, T. Bloom, P. Bork, M. Botcherby, N. Bray, M. R. Brent, D. G. Brown, S. D. Brown, C. Bult, J. Burton, J. Butler, R. D. Campbell, P. Carninci, S. Cawley, F. Chiaromonte, A. T. Chinwalla, D. M. Church, M. Clamp, C. Clee, F. S. Collins, L. L. Cook, R. R. Copley, A. Coulson, O. Couronne, J. Cuff, V. Curwen, T. Cutts, M. Daly, R. David, J. Davies, K. D. Delehaunty, J. Deri, E. T. Dermitzakis, C. Dewey, N. J. Dickens, M. Diekhans, S. Dodge, I. Dubchak, D. M. Dunn, S. R. Eddy, L. Elnitski, R. D. Emes, P. Eswara, E. Eyras, A. Felsenfeld, G. A. Fewell, P. Flicek, K. Foley, W. N. Frankel, L. A. Fulton, R. S. Fulton, T. S. Furey, D. Gage, R. A. Gibbs, G. Glusman, S. Gnerre, N. Goldman, L. Goodstadt, D. Grafham, T. A. Graves, E. D. Green, S. Gregory, R. Guigo, M. Guyer, R. C. Hardison, D. Haussler, Y. Hayashizaki, L. W. Hillier, A. Hinrichs, W. Hlavina, T. Holzer, F. Hsu, A. Hua, T. Hubbard, A. Hunt, I. Jackson, D. B. Jaffe, L. S. Johnson, M. Jones, T. A. Jones, A. Joy, M. Kamal, E. K. Karlsson, D. Karolchik, A. Kasprzyk, J. Kawai, E. Keibler, C. Kells, W. J. Kent, A. Kirby, D. L. Kolbe, I. Korf, R. S. Kucherlapati, E. J. Kulbokas, D. Kulp, T. Landers, J. P. Leger, S. Leonard, I. Letunic, R. Levine, J. Li, M. Li, C. Lloyd, S. Lucas, B. Ma, D. R. Maglott, E. R. Mardis, L. Matthews, E. Mauceli, J. H. Mayer, M. McCarthy, W. R. McCombie, S. McLaren, K. McLay, J. D. McPherson, J. Meldrim, B. Meredith, J. P. Mesirov, W. Miller, T. L. Miner, E. Mongin, K. T. Montgomery, M. Morgan, R. Mott, J. C. Mullikin, D. M. Muzny, W. E. Nash, J. O. Nelson, M. N. Nhan, R. Nicol, Z. Ning, C. Nusbaum, M. J. O'Connor, Y. Okazaki, K. Oliver, E. Overton-Larty, L. Pachter, G. Parra, K. H. Pepin, J. Peterson, P. Pevzner, R. Plumb, C. S. Pohl, A. Poliakov, T. C. Ponce, C. P. Ponting, S. Potter, M. Quail, A. Reymond, B. A. Roe, K. M. Roskin, E. M. Rubin, A. G. Rust, R. Santos, V. Sapojnikov, B. Schultz, J. Schultz, M. S. Schwartz, S. Schwartz, C. Scott, S. Seaman, S. Searle, T. Sharpe, A. Sheridan, R. Shownkeen, S. Sims, J. B. Singer, G. Slater, A. Smit, D. R. Smith, B. Spencer, A. Stabenau, N. Stange-Thomann, C. Sugnet, M. Suyama, G. Tesler, J. Thompson, D. Torrents, E. Trevaskis, J. Tromp, C. Ucla, A. Ureta-Vidal, J. P. Vinson, A. C. Von Niederhausern, C. M. Wade, M. Wall, R. J. Weber, R. B. Weiss, M. C. Wendl, A. P. West, K. Wetterstrand, R. Wheeler, S. Whelan, J. Wierzbowski, D. Willey, S. Williams, R. K. Wilson, E. Winter, K. C. Worley, D. Wyman, S. Yang, S. P. Yang, E. M. Zdobnov, M. C. Zody, and E. S. Lander. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature 420(6915):520-562. Watson, H. 2011. Chimpanzees in biomedical research [slide presentation].
196. Watson, H. 2011. Chimpanzees in biomedical research [slide presentation] Presented to the Committee on the Use of Chimpanzees in Biomedical and Behavioral Research, May 26, 2011, Washington, DC.
197. Weisman, L. E. 2009. Respiratory syncytial virus (RSV) prevention and treatment: Past, present, and future. Cardiovasc Hematol Agents Med Chem 7(3):223-233.
198. WHO (World Health Organization). 2003. Netherlands. Law of 2 October 2003 (stb. 399) amending the law on animal experimentation. International Digest of Health Legislation. http://apps.who.int/idhl-rils/results.cfm? language=english&type=ByIssue&intDigestVolume=54&intIssue=4&strTopic Code=XIA (accessed August 24, 2011).
199. WHO. 2011. Hepatitis C. World Health Organization (WHO) Media Centre. Geneva.
200. Williams, I. T., B. P. Bell, W. Kuhnert, and M. J. Alter. 2011. Incidence and transmission patterns of acute hepatitis C in the United States, 1982-2006. Arch Intern Med 171(3):242-248.
201. Wright, M., and G. Piedimonte. 2011. Respiratory syncytial virus prevention and therapy: Past, present, and future. Pediatr Pulmonol 46(4):324-347.
202. Wu, G. Y., M. Konishi, C. M. Walton, D. Olive, K. Hayashi, and C. H. Wu. 2005. A novel immunocompetent rat model of HCV infection and hepatitis. Gastroenterology 128(5):1416-1423.
203. Yerkes National Primate Research Center. 2011. About. http://www.yerkes.emory. edu/about/index.html (accessed July 27, 2011).
204. Zanetti, A. R., E. Tanzi, S. Paccagnini, N. Principi, G. Pizzocolo, M. L. Caccamo, E. D'Amico, G. Cambie, and L. Vecchi. 1995. Mother-to-infant transmission of hepatitis C virus. Lombardy study group on vertical HCV transmission. Lancet 345(8945):289-291.
205. Zhong, J., P. Gastaminza, G. Cheng, S. Kapadia, T. Kato, D. R. Burton, S. F. Wieland, S. L. Uprichard, T. Wakita, and F. V. Chisari. 2005. Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci USA 102(26):9294- 9299.
206. Abe, K., G. Inchauspe, T. Shikata, and A. M. Prince. 1992. Three different patterns of hepatitis C virus infection in chimpanzees. Hepatology 15:690- 695.
207. Abi-Rached, L., A. K. Moesta, R. Rajalingam, L. A. Guethlein, and P. Parham. 2010. Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. PLoS Genet 6:e1001192.
208. Aggarwal, R. 2011. Hepatitis E: Historical, contemporary and future perspectives. J Gastroenterol Hepatol 26(Suppl 1):72-82.
209. Akondy, R. S., N. D. Monson, J. D. Miller, S. Edupuganti, D. Teuwen, H. Wu, F. Quyyumi, S. Garg, J. D. Altman, C. Del Rio, H. L. Keyserling, A. Ploss, C. M. Rice, W. A. Orenstein, M. J. Mulligan, and R. Ahmed. 2009. The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response. J Immunol 183:7919-7930.
210. Alter, H. J., R. H. Purcell, P. V. Holland, and H. Popper. 1978. Transmissible agent in non-A, non-B hepatitis. Lancet 1:459-463.
211. Alter, H. J., J. W. Eichberg, H. Masur, W. C. Saxinger, R. Gallo, A. M. Macher, H. C. Lane, and A. S. Fauci. 1984. Transmission of HTLV-III infection from human plasma to chimpanzees: An animal model for AIDS. Science 226:549-552.
212. Amako, Y., K. Tsukiyama-Kohara, A. Katsume, Y. Hirata, S. Sekiguchi, Y. Tobita, Y. Hayashi, T. Hishima, N. Funata, H. Yonekawa, and M. Kohara. 2010. Pathogenesis of hepatitis C virus infection in Tupaia belangeri. J Virol 84:303-311.
213. Asabe, S., S. F. Wieland, P. K. Chattopadhyay, M. Roederer, R. E. Engle, R. H. Purcell, and F.V. Chisari. 2009. The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol 83:9652-9662.
214. Aspinall, R., J. Pido-Lopez, N. Imami, S. M. Henson, P. T. Ngom, M. Morre, H. Niphuis, E. Remarque, B. Rosenwirth, and J. L. Heeney. 2007. Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination. Rejuv Res 10:5-17.
215. Baba, T. W., Y. S. Jeong, D. Penninck, R. Bronson, M. F. Greene, and R. M. Ruprecht. 1995. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267:1820-1825.
216. Bach, F. H., M. A. Engstrom, M. L. Bach, and K. W. Sell. 1972. Histocompatibility matching. VII. Mixed leukocyte cultures between chimpanzee and man. Transplant Proc 4:97-100.
217. Balner, H., A. van Leeuwen, H. Dersjant, and J. J. van Rood. 1967. Defined leukocyte antigens of chimpanzees: Use of chimpanzee isoantisera for leukocyte typing in man. Transplantation 5:624-642.
218. Barber, D. L., E. J. Wherry, R. J. Greenwald, A. H. Sharpe, G. J. Freeman, and R. Ahmed. 2004. PD-L1 blockade restores CD8 T cell function during chronic viral infection [Abstract]. Clinical and Investigative Medicine 27:8C.
219. Barker, L. F., F. V. Chisari, P. P. McGrath, D. W. Dalgard, R. L. Kirschstein, J. D. Almeida, T. S. Edington, D. G. Sharp, and M. R. Peterson. 1973. Transmission of type B viral hepatitis to chimpanzees. J Infect Dis 127:648- 662.
220. Barker, L. F., J. E. Maynard, R. H. Purcell, J. H. Hoofnagle, K. R. Berquist, and W. T. London. 1975a. Viral hepatitis, type B, in experimental animals. Am J Med Sci 270:189-195.
221. Barker, L. F., J. E. Maynard, R. H. Purcell, J. H. Hoofnagle, K. R. Berquist, W. T. London, R. J. Gerety, and D. H. Krushak. 1975b. Hepatitis B virus infection in chimpanzees: Titration of subtypes. J Infect Dis 132:451-458.
222. Barouch, D. H., and N. L. Letvin. 2000. Cytokine-induced augmentation of DNA vaccine-elicited SIV-specific immunity in rhesus monkeys. Dev Biol (Basel) 104:85-92.
223. Barr, C. S., S. A. Chen, M. L. Schwandt, S. G. Lindell, H. Sun, S. J. Suomi, and M. Heilig. 2010. Suppression of alcohol preference by naltrexone in the rhesus macaque: A critical role of genetic variation at the micro-opioid receptor gene locus. Biol Psychiat 67:78-80.
224. Barreiro, L. B., and L. Quintana-Murci. 2010. From evolutionary genetics to human immunology: How selection shapes host defence genes. Nat Rev Genet 11:17-30.
225. Barreiro, L. B., J. C. Marioni, R. Blekhman, M. Stephens, and Y. Gilad. 2010. Functional comparison of innate immune signaling pathways in primates. PLoS Genet 6:e1001249.
226. Barth, H., J. Rybczynska, R. Patient, Y. Choi, R. K. Sapp, T. F. Baumert, K. Krawczynski, and T. J. Liang. 2011. Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees. Hepatology 54:1135-1148.
227. Bassett, S.E., K.M. Brasky, and R.E. Lanford. 1998. Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles. J Virol 72:2589-2599.
228. Ben-Yehudah, A., C. A. T. Easley, B. P. Hermann, C. Castro, C. Simerly, K. E. Orwig, S. Mitalipov, and G. Schatten. 2010. Systems biology discoveries using non-human primate pluripotent stem and germ cells: Novel gene and genomic imprinting interactions as well as unique expression patterns. Stem Cell Research & Therapy 1:24.
229. Berman, P., J. Groopman, T. Gregory, P. Clapham, R. Weiss, R. Ferriarri, L. Riddle, C. Shimasaki, C. Lucas, L. Lasky, and J. Eichberg. 1988. HIV-1 challenge of chimpanzees immunized with recombinant gp120. P Natl Acad Sci USA 85:5200.
230. Bethea, C. L., J. M. Streicher, K. Coleman, F. K. Pau, R. Moessner, and J. L. Cameron. 2004. Anxious behavior and fenfluramine-induced prolactin secretion in young rhesus macaques with different alleles of the serotonin reuptake transporter polymorphism (5HTTLPR). Behav Genet 34:295-307.
231. Bimber, B. N., A. J. Moreland, R. W. Wiseman, A. L. Hughes, and D. H. O'Connor. 2008. Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: Novel insights into nonhuman primate KIR gene content and organization. J Immunol 181:6301-6308.
232. Blount, R. E., Jr., J. A. Morris, and R. E. Savage. 1956. Recovery of cytopathogenic agent from chimpanzees with coryza. Proc Soc Exp Biol Med 92:544-549.
233. Boni, C., P. Fisicaro, C. Valdatta, B. Amadei, P. Di Vincenzo, T. Giuberti, D. Laccabue, A. Zerbini, A. Cavalli, G. Missale, A. Bertoletti, and C. Ferrari. 2007. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 81:4215-4225.
234. Bontrop, R. E., and D. I. Watkins. 2005. MHC polymorphism: AIDS susceptibility in non-human primates. Trends Immunol 26:227-233.
235. Bowen, D. G., and C. M. Walker. 2005. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 436:946-952.
236. Boyson, J. E., C. Shufflebotham, L. F. Cadavid, J. A. Urvater, L. A. Knapp, A. L. Hughes, and D. I. Watkins. 1996. The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates. J Immunol 156:4656-4665.
237. Bradley, D. W., J. E. Maynard, H. Popper, E. H. Cook, J. W. Ebert, K. A. McCaustland, C. A. Schable, and H. A. Fields. 1983. Posttransfusion non-A, non-B hepatitis: Physicochemical properties of two distinct agents. J Infect Dis 148:254-265.
238. Bradley, D. W., K. A. McCaustland, E. H. Cook, C. A. Schable, J. W. Ebert, and J. E. Maynard. 1985. Posttransfusion non-A, non-B hepatitis in chimpanzees. Physicochemical evidence that the tubule-forming agent is a small, enveloped virus. Gastroenterology 88:773-779.
239. Brenchley, J. M., D. A. Price, T. W. Schacker, T. E. Asher, G. Silvestri, S. Rao, Z. Kazzaz, E. Bornstein, O. Lambotte, D. Altmann, B. R. Blazar, B. Rodriguez, L. Teixeira-Johnson, A. Landay, J. N. Martin, F. M. Hecht, L. J. Picker, M. M. Lederman, S. G. Deeks, and D. C. Douek. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12:1365-1371.
240. Buchbinder, S. P., D. V. Mehrotra, A. Duerr, D. W. Fitzgerald, R. Mogg, D. Li, P. B. Gilbert, J. R. Lama, M. Marmor, C. Del Rio, M. J. McElrath, D. R. Casimiro, K. M. Gottesdiener, J. A. Chodakewitz, L. Corey, and M. N. Robertson. 2008. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the STEP Study): A double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 372:1881-1893.
241. Bukh, J., C. L. Apgar, S. Govindarajan, S. U. Emerson, and R. H. Purcell. 2001. Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a. J Viral Hepat 8:228-231.
242. Bukreyev, A. A., J. M. Dinapoli, L. Yang, B. R. Murphy, and P. L. Collins. 2010. Mucosal parainfluenza virus-vectored vaccine against Ebola virus replicates in the respiratory tract of vector-immune monkeys and is immunogenic. Virology 399:290-298.
243. Buynak, E. B., R. R. Roehm, A. A. Tytell, A. U. Bertland, 2nd, G. P. Lampson, and M. R. Hilleman. 1976a. Development and chimpanzee testing of a vaccine against human hepatitis B. Proc Soc Exp Biol Med 151:694-700.
244. Buynak, E. B., R. R. Roehm, A. A. Tytell, A. U. Bertland, 2nd, G. P. Lampson, and M. R. Hilleman. 1976b. Vaccine against human hepatitis B. JAMA 235:2832-2834.
245. Callendret, B., and C. Walker. 2011. A siege of hepatitis: Immune boost for viral hepatitis. Nat Med 17:252-253.
246. Casimiro, D. R., K. Cox, A. Tang, K. J. Sykes, M. Feng, F. Wang, A. Bett, W. A. Schleif, X. Liang, J. Flynn, T. W. Tobery, K. Wilson, A. Finnefrock, L. Huang, S. Vitelli, J. Lin, D. Patel, M. E. Davies, G. J. Heidecker, D. C. Freed, S. Dubey, D. H. O'Connor, D. I. Watkins, Z. Q. Zhang, and J. W. Shiver. 2010. Efficacy of multivalent adenovirus-based vaccine against simian immunodeficiency virus challenge. J Virol 84:2996-3003.
247. Chanock, R. M., and L. Finberg. 1957. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiological aspects of infection in infants and young children. Am J Hyg 66:291-300.
248. Chanock, R. M., B. Roizman, and R. Myers. 1957. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent. I. Isolation, properties and characterization. Am J Hyg 66:281-290.
249. Chen, C. Y., D. Huang, R. C. Wang, L. Shen, G. Zeng, S. Yao, Y. Shen, L. Halliday, J. Fortman, M. McAllister, J. Estep, R. Hunt, D. Vasconcelos, G. Du, S. A. Porcelli, M. H. Larsen, W. R. Jacobs, Jr., B. F. Haynes, N. L. Letvin, and Z. W. Chen. 2009. A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. PLoS Pathog 5:e1000392.
250. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
251. Cohen, J. 1999. AIDS vaccine. Chimps and lethal strain a bad mix. Science 286:1454-1455.
252. Cole, K. S., J. L. Rowles, B. A. Jagesrski, M. Murphey-Corb, T. Unangst, J. E. Clements, J. Robinson, M. S. Wyand, R. C. Desrosiers, and R. C. Montelaro. 1997. Evolution of envelope-specific antibody responses in monkeys experimentally infected or immunized with simian immunodeficiency virus and its association with the development of protective immunity. J Virol 71:5069-5079.
253. Cole, K. S., M. Alvarez, D. H. Elliott, H. Lam, E. Martin, T. Chau, K. Micken, J. L. Rowles, J. E. Clements, M. Murphey-Corb, R. C. Montelaro, and J. E. Robinson. 2001. Characterization of neutralization epitopes of simian immunodeficiency virus (SIV) recognized by rhesus monoclonal antibodies derived from monkeys infected with an attenuated SIV strain. Virology 290:59-73.
254. Conley, A. J., J. A. Kessler, II, L. J. Boots, P. M. McKenna, W. A. Schleif, E. A. Emini, G. E. Mark, III, H. Katinger, E. K. Cobb, S. M. Lunceford, S. R. Rouse, and K. K. Murthy. 1996. The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate. J Virol 70:6751-6758.
255. Cooper, S., H. Kowalski, A. L. Erickson, K. Arnett, A. M. Little, C. M. Walker, and P. Parham. 1996. The presentation of a hepatitis C viral peptide by distinct major histocompatibility complex class I allotypes from two chimpanzee species. J Exp Med 183:663-668.
256. Crowe, J. E., Jr., P. L. Collins, W. T. London, R. M. Chanock, and B. R. Murphy. 1993. A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperaturesensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV. Vaccine 11:1395-1404.
257. Crowe, J. E., Jr., P. T. Bui, W. T. London, A. R. Davis, P. P. Hung, R. M. Chanock, and B. R. Murphy. 1994. Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis. Vaccine 12:691-699.
258. Currier, J. R., K. S. Stevenson, P. J. Kehn, K. Zheng, V. M. Hirsch, and M. A. Robinson. 1999. Contributions of CD4+, CD8+, and CD4+CD8+ T cells to skewing within the peripheral T cell receptor beta chain repertoire of healthy macaques. Hum Immunol 60:209-222.
259. Dahari, H., S. M. Feinstone, and M. E. Major. 2010. Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins. Gastroenterology 139:965-974.
260. Daniel, M. D., N. L. Letvin, N. W. King, M. Kannagi, P. K. Sehgal, R. D. Hunt, P. J. Kanki, M. Essex, and R. C. Desrosiers. 1985. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228:1201-1204.
261. Daubersies, P., A. W. Thomas, P. Millet, K. Brahimi, J. A. Langermans, B. Ollomo, L. BenMohamed, B. Slierendregt, W. Eling, A. Van Belkum, G. Dubreuil, J. F. Meis, C. Guerin-Marchand, S. Cayphas, J. Cohen, H. Gras-Masse, and P. Druilhe. 2000. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liverstage antigen 3. Nat Med 6:1258-1263.
262. Daubersies, P., B. Ollomo, J. P. Sauzet, K. Brahimi, B. L. Perlaza, W. Eling, H. Moukana, P. Rouquet, C. de Taisne, and P. Druilhe. 2008. Genetic immunisation by liver stage antigen 3 protects chimpanzees against malaria despite low immune responses. PloS one 3:e2659.
263. De Berardinis, P., L. D'Apice, A. Prisco, M. N. Ombra, P. Barba, G. Del Pozzo, S. Petukhov, P. Malik, R. N. Perham, and J. Guardiola. 1999. Recognition of HIV-derived B and T cell epitopes displayed on filamentous phages. Vaccine 17:1434-1441.
264. de Groot, N. G., C. M. Heijmans, N. de Groot, G. G. Doxiadis, N. Otting, and R. E. Bontrop. 2009. The chimpanzee Mhc-DRB region revisited: Gene content, polymorphism, pseudogenes, and transcripts. Mol Immunol 47:381- 389.
265. de Groot, N. G., C. M. Heijmans, Y. M. Zoet, A. H. de Ru, F. A. Verreck, P. A. van Veelen, J. W. Drijfhout, G. G. Doxiadis, E. J. Remarque, Doxiadis, II, J. J. van Rood, F. Koning, and R. E. Bontrop. 2010. AIDS-protective HLAB* 27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz. P Natl Acad Sci USA 107:15175-15180.
266. Diedrich, C. R., J. T. Mattila, E. Klein, C. Janssen, J. Phuah, T. J. Sturgeon, R. C. Montelaro, P. L. Lin, and J. L. Flynn. 2010. Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. PloS one 5:e9611.
267. Dienstag, J. L., S. M. Feinstone, R. H. Purcell, J. H. Hoofnagle, L. F. Barker, W. T. London, H. Popper, J. M. Peterson, and A. Z. Kapikian. 1975. Experimental infection of chimpanzees with hepatitis A virus. J Infect Dis 132:532-545.
268. Dienstag, J. L., H. Popper, and R. H. Purcell. 1976. The pathology of viral hepatitis types A and B in chimpanzees. A comparison. Am J Patho 85:131- 148.
269. Donahue, R. E., and C. E. Dunbar. 2001. Update on the use of nonhuman primate models for preclinical testing of gene therapy approaches targeting hematopoietic cells. Hum Gene Ther 12:607-617.
270. Doria-Rose, N. A., C. Ohlen, P. Polacino, C. C. Pierce, M. T. Hensel, L. Kuller, T. Mulvania, D. Anderson, P. D. Greenberg, S. L. Hu, and N. L. Haigwood. 2003. Multigene DNA priming-boosting vaccines protect macaques from acute CD4+-T-cell depletion after simian-human immunodeficiency virus SHIV89.6P mucosal challenge. J Virol 77:11563-11577.
271. Doria-Rose, N. A., R. M. Klein, M. M. Manion, S. O'Dell, A. Phogat, B. Chakrabarti, C. W. Hallahan, S. A. Migueles, J. Wrammert, R. Ahmed, M. Nason, R. T. Wyatt, J. R. Mascola, and M. Connors. 2009. Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J Virol 83:188- 199.
272. Doxiadis, G. G., C. M. Heijmans, N. Otting, and R. E. Bontrop. 2007. MIC gene polymorphism and haplotype diversity in rhesus macaques. Tissue Antigens 69:212-219.
273. Earl, P. L., J. L. Americo, L. S. Wyatt, L. A. Eller, J. C. Whitbeck, G. H. Cohen, R. J. Eisenberg, C. J. Hartmann, D. L. Jackson, D. A. Kulesh, M. J. Martinez, D. M. Miller, E. M. Mucker, J. D. Shamblin, S. H. Zwiers, J. W. Huggins, P. B. Jahrling, and B. Moss. 2004. Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox. Nature 428:182-185.
274. Earl, P. L., J. L. Americo, L. S. Wyatt, O. Espenshade, J. Bassler, K. Gong, S. Lin, E. Peters, L. Rhodes, Jr., Y. E. Spano, P. M. Silvera, and B. Moss. 2008. Rapid protection in a monkeypox model by a single injection of a replication-deficient vaccinia virus. P Natl Acad Sci USA 105:10889-10894.
275. Edghill-Smith, Y., H. Golding, J. Manischewitz, L. R. King, D. Scott, M. Bray, A. Nalca, J. W. Hooper, C. A. Whitehouse, J. E. Schmitz, K. A. Reimann, and G. Franchini. 2005. Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus. Nature Medicine 11:740-747.
276. Eichberg, J. W., J. M. Zarling, H. J. Alter, J. A. Levy, P. W. Berman, T. Gregory, L. A. Lasky, J. McClure, K. E. Cobb, P. A. Moran, S. Hu, R. C. Kennedy, T. C. Chanh, and G. R. Dreesman. 1987. T-cell responses to human immunodeficiency virus (HIV) and its recombinant antigens in HIVinfected chimpanzees. J Virol 61:3804-3808.
277. El-Amad, Z., K. K. Murthy, K. Higgins, E. K. Cobb, N. L. Haigwood, J. A. Levy, and K. S. Steimer. 1995. Resistance of chimpanzees immunized with recombinant gp120SF2 to challenge by HIV-1SF2. AIDS 9:1313-1322.
278. Emini, E. A., P. L. Nara, W. A. Schlief, J. A. Lewis, J. P. Davide, D. R. Lee, J. Kessler, S. Conley, S. Matsushita, S. D. Putney, R. J. Gerety, and J. W. Eichberg. 1990. Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees. J Virol 64:3674-3678.
279. Estep, R. D., I. Messaoudi, M. A. O'Connor, H. Li, J. Sprague, A. Barron, F. Engelmann, B. Yen, M. F. Powers, J. M. Jones, B. A. Robinson, B. U. Orzechowska, M. Manoharan, A. Legasse, S. Planer, J. Wilk, M. K. Axthelm, and S. W. Wong. 2011. Deletion of the monkeypox inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a non human model of infection. J Virol.
280. Fang, X., Y. Zhang, R. Zhang, L. Yang, M. Li, K. Ye, X. Guo, J. Wang, and B. Su. 2011. Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque. Genome Biol 12:R63.
281. Farci, P., H. J. Alter, S. Govindarajan, D. C. Wong, R. Engle, R. R. Lesniewski, I. K. Mushahwar, S. M. Desai, R. H. Miller, N. Ogata, and et al. 1992. Lack of protective immunity against reinfection with hepatitis C virus. Science 258:135-140.
282. Feinstone, S. M., A. Z. Kapikian, R. H. Purcell, H. J. Alter, and P. V. Holland. 1975. Transfusion-associated hepatitis not due to viral hepatitis type A or B. N Engl J Med 292:767-770.
283. Feinstone, S. M., R. J. Daemer, I. D. Gust, and R. H. Purcell. 1983. Live attenuated vaccine for hepatitis A. Dev Biol Stand 54:429-432.
284. Folgori, A., S. Capone, L. Ruggeri, A. Meola, E. Sporeno, B. B. Ercole, M. Pezzanera, R. Tafi, M. Arcuri, E. Fattori, A. Lahm, A. Luzzago, A. Vitelli, S. Colloca, R. Cortese, and A. Nicosia. 2006. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat Med 12:190-197.
285. Frank, I., M. Piatak, Jr., H. Stoessel, N. Romani, D. Bonnyay, J. D. Lifson, and M. Pope. 2002. Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs. J Virol 76:2936- 2951.
286. Fultz, P. N., H. M. McClure, H. Daugharty, A. Brodie, C. R. McGrath, B. Swenson, and D. P. Francis. 1986. Vaginal transmission of human immunodeficiency virus (HIV) to a chimpanzee. J Infect Dis 154:896-900.
287. Fultz, P. N., A. Srinivasan, C. R. Greene, D. Butler, R. B. Swenson, and H. M. McClure. 1987. Superinfection of a chimpanzee with a second strain of human immunodeficiency virus. J Virol 61:4026-4029.
288. Gao, F., D. L. Robertson, C. D. Carruthers, Y. Li, E. Bailes, L. G. Kostrikis, M. O. Salminen, F. Bibollet-Ruche, M. Peeters, D. D. Ho, G. M. Shaw, P. M. Sharp, and B. H. Hahn. 1999. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397:436-441.
289. Gao, X., Y. Jiao, L. Wang, X. Liu, W. Sun, B. Cui, Z. Chen, and Y. Zhao. 2010. Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B. Clin Immunol 137:139-146.
290. Genesca, M., M. B. McChesney, and C. J. Miller. 2009. Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6. J Intern Med 265:67-77.
291. Gibbs, R. A., J. Rogers, M. G. Katze, R. Bumgarner, G. M. Weinstock, E. R. Mardis, K. A. Remington, R. L. Strausberg, J. C. Venter, R. K. Wilson, M. A. Batzer, C. D. Bustamante, E. E. Eichler, M. W. Hahn, R. C. Hardison, K. D. Makova, W. Miller, A. Milosavljevic, R. E. Palermo, A. Siepel, J. M. Sikela, T. Attaway, S. Bell, K. E. Bernard, C. J. Buhay, M. N. Chandrabose, M. Dao, C. Davis, K. D. Delehaunty, Y. Ding, H. H. Dinh, S. Dugan-Rocha, L. A. Fulton, R. A. Gabisi, T. T. Garner, J. Godfrey, A. C. Hawes, J. Hernandez, S. Hines, M. Holder, J. Hume, S. N. Jhangiani, V. Joshi, Z. M. Khan, E. F. Kirkness, A. Cree, R. G. Fowler, S. Lee, L. R. Lewis, Z. Li, Y. S. Liu, S. M. Moore, D. Muzny, L. V. Nazareth, D. N. Ngo, G. O. Okwuonu, G. Pai, D. Parker, H. A. Paul, C. Pfannkoch, C. S. Pohl, Y. H. Rogers, S. J. Ruiz, A. Sabo, J. Santibanez, B. W. Schneider, S. M. Smith, E. Sodergren, A. F. Svatek, T. R. Utterback, S. Vattathil, W. Warren, C. S. White, A. T. Chinwalla, Y. Feng, A. L. Halpern, L. W. Hillier, X. Huang, P. Minx, J. O. Nelson, K. H. Pepin, X. Qin, G. G. Sutton, E. Venter, B. P. Walenz, J. W. Wallis, K. C. Worley, S. P. Yang, S. M. Jones, M. A. Marra, M. Rocchi, J. E. Schein, R. Baertsch, L. Clarke, M. Csuros, J. Glasscock, R. A. Harris, P. Havlak, A. R. Jackson, H. Jiang, Y. Liu, D. N. Messina, Y. Shen, H. X. Song, T. Wylie, L. Zhang, E. Birney, K. Han, M. K. Konkel, J. Lee, A. F. Smit, B. Ullmer, H. Wang, J. Xing, R. Burhans, Z. Cheng, J. E. Karro, J. Ma, B. Raney, X. She, M. J. Cox, J. P. Demuth, L. J. Dumas, S. G. Han, J. Hopkins, A. Karimpour-Fard, Y. H. Kim, J. R. Pollack, T. Vinar, C. Addo-Quaye, J. Degenhardt, A. Denby, M. J. Hubisz, A. Indap, C. Kosiol, B. T. Lahn, H. A. Lawson, A. Marklein, R. Nielsen, E. J. Vallender, A. G. Clark, B. Ferguson, R. D. Hernandez, K. Hirani, H. Kehrer-Sawatzki, J. Kolb, S. Patil, L. L. Pu, Y. Ren, D. G. Smith, D. A. Wheeler, I. Schenck, E. V. Ball, R. Chen, D. N. Cooper, B. Giardine, F. Hsu, W. J. Kent, A. Lesk, D. L. Nelson, E. O'Brien W, K. Prufer, P. D. Stenson, J. C. Wallace, H. Ke, X. M. Liu, P. Wang, A. P. Xiang, F. Yang, G. P. Barber, D. Haussler, D. Karolchik, A. D. Kern, R. M. Kuhn, K. E. Smith, and A. S. Zwieg. 2007. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316:222-234.
292. Giles, G. R., H. J. Boehmig, H. Amemiya, C. G. Halgrimson, and T. E. Starzl. 1970. Clinical heterotransplantation of the liver. Transplant Proc 2:506- 512.
293. Glamann, J., D. R. Burton, P. W. Parren, H. J. Ditzel, K. A. Kent, C. Arnold, D. Montefiori, and V. M. Hirsch. 1998. Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque. J Virol 72:585-592.
294. Golden-Mason, L., B. Palmer, J. Klarquist, J. A. Mengshol, N. Castelblanco, and H. R. Rosen. 2007. Upregulation of PD-1 expression on circulating and intrahepatic HCV-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 81:9249-9258.
295. Good, M. F. 2011. Our impasse in developing a malaria vaccine. Cell Mol Life Sci 68:1105-1113.
296. Good, M. F., and D. L. Doolan. 2010. Malaria vaccine design: Immunological considerations. Immunity 33:555-566.
297. Goulder, P. J., and D. I. Watkins. 2008. Impact of MHC class I diversity on immune control of immunodeficiency virus replication. Nat Rev Immunol 8:619-630.
298. Graham, B. S. 2011. Biological challenges and technological opportunities for respiratory syncytial virus vaccine development. Immunol Rev 239:149-166.
299. Grakoui, A., N. H. Shoukry, D. J. Woollard, J. H. Han, H. L. Hanson, J. Ghrayeb, K. K. Murthy, C. M. Rice, and C. M. Walker. 2003. HCV persistence and immune evasion in the absence of memory T cell help. Science 302:659-662.
300. Grove, K. L., B. E. Grayson, M. M. Glavas, X. Q. Xiao, and M. S. Smith. 2005. Development of metabolic systems. Physiol Behav 86:646-660.
301. Grunbaum, A. S. 1904. Report LXXXIII: Some Experiments on Enterica, Scarlet Fever, and Measles in the Chimpanzee: [A Preliminary Communication]. Br Med J 1:817-819.
302. Guenaga, J., P. Dosenovic, G. Ofek, D. Baker, W. R. Schief, P. D. Kwong, G. B. Karlsson Hedestam, and R. T. Wyatt. 2011. Heterologous epitopescaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant. PLoS One 6:e16074.
303. Guidotti, L. G., R. Rochford, J. Chung, M. Shapiro, R. Purcell, and F. V. Chisari. 1999. Viral clearance without destruction of infected cells during acute HBV infection. Science 284:825-829.
304. Ha, S. J., S. N. Mueller, E. J. Wherry, D. L. Barber, R. D. Aubert, A. H. Sharpe, G. J. Freeman, and R. Ahmed. 2008. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med 205:543-555.
305. Hahn, B. H., G. M. Shaw, K. M. De Cock, and P. M. Sharp. 2000. AIDS as a zoonosis: scientific and public health implications. Science 287:607-614.
306. Haigwood, N. L. 2009. Update on animal models for HIV research. Eur J Immunol 39:1994-1999.
307. Haining, W. N., and E. J. Wherry. 2010. Integrating genomic signatures for immunologic discovery. Immunity 32:152-161.
308. Hall, C. B., G. A. Weinberg, M. K. Iwane, A. K. Blumkin, K. M. Edwards, M. A. Staat, P. Auinger, M. R. Griffin, K. A. Poehling, D. Erdman, C. G. Grijalva, Y. Zhu, and P. Szilagyi. 2009. The burden of respiratory syncytial virus infection in young children. N Engl J Med 360:588-598.
309. Hansen, S. G., C. Vieville, N. Whizin, L. Coyne-Johnson, D. C. Siess, D. D. Drummond, A. W. Legasse, M. K. Axthelm, K. Oswald, C. M. Trubey, M. Piatak, Jr., J.D. Lifson, J. A. Nelson, M. A. Jarvis, and L. J. Picker. 2009. Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med 15:293-299.
310. Hansen, S. G., C. J. Powers, R. Richards, A. B. Ventura, J. C. Ford, D. Siess, M. K. Axthelm, J. A. Nelson, M. A. Jarvis, L. J. Picker, and K. Fruh. 2010. Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science 328:102-106.
311. Hansen, S. G., J. C. Ford, M. S. Lewis, A. B. Ventura, C. M. Hughes, L. Coyne- Johnson, N. Whizin, K. Oswald, R. Shoemaker, T. Swanson, A. W. Legasse, M. J. Chiuchiolo, C. L. Parks, M. K. Axthelm, J. A. Nelson, M. A. Jarvis, M. Piatak, Jr., J. D. Lifson, and L. J. Picker. 2011. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473:523-527.
312. Harouse, J. M., A. Gettie, T. Eshetu, R. C. Tan, R. Bohm, J. Blanchard, G. Baskin, and C. Cheng-Mayer. 2001. Mucosal transmission and induction of simian AIDS by CCR5-specific simian/human immunodeficiency virus SHIV(SF162P3). J Virol 75:1990-1995.
313. Hayton, K., D. Gaur, A. Liu, J. Takahashi, B. Henschen, S. Singh, L. Lambert, T. Furuya, R. Bouttenot, M. Doll, F. Nawaz, J. Mu, L. Jiang, L. H. Miller, and T. E. Wellems. 2008. Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion. Cell Host Microbe 4:40-51.
314. Hel, Z., J. Nacsa, W. P. Tsai, A. Thornton, L. Giuliani, J. Tartaglia, and G. Franchini. 2002. Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques. Virology 304:125-134.
315. Heraud, J. M., Y. Edghill-Smith, V. Ayala, I. Kalisz, J. Parrino, V. S. Kalyanaraman, J. Manischewitz, L.R. King, A. Hryniewicz, C. J. Trindade, M. Hassett, W. P. Tsai, D. Venzon, A. Nalca, M. Vaccari, P. Silvera, M. Bray, B. S. Graham, H. Golding, J. W. Hooper, and G. Franchini. 2006. Subunit recombinant vaccine protects against monkeypox. J Immunol 177:2552-2564.
316. Hessell, A. J., P. Poignard, M. Hunter, L. Hangartner, D. M. Tehrani, W. K. Bleeker, P. W. Parren, P. A. Marx, and D. R. Burton. 2009a. Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nat Med 15:951-954.
317. Hessell, A. J., E. G. Rakasz, P. Poignard, L. Hangartner, G. Landucci, D. N. Forthal, W. C. Koff, D. I. Watkins, and D. R. Burton. 2009b. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog 5:e1000433.
318. Hirsch, V. M., and J. D. Lifson. 2000. Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and prevention. Adv Pharmacol 49:437-477.
319. Hirsch, V. M., G. Dapolito, A. Hahn, J. Lifson, D. Montefiori, C. R. Brown, and R. Goeken. 1998. Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia. J Virol 72:6482-6489.
320. Hoffman, S. L., and D. L. Doolan. 2000. Malaria vaccines-targeting infected hepatocytes. Nat Med 6:1218-1219.
321. Hu, X., H. S. Margolis, R. H. Purcell, J. Ebert, and B. H. Robertson. 2000. Identification of hepatitis B virus indigenous to chimpanzees. P Natl Acad Sci USA 97:1661-1664.
322. Huang, K. H., D. Bonsall, A. Katzourakis, E. C. Thomson, S. J. Fidler, J. Main, D. Muir, J. N. Weber, A. J. Frater, R. E. Phillips, O. G. Pybus, P. J. Goulder, M. O. McClure, G. S. Cooke, and P. Klenerman. 2010. B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection. Nature Commu 1:102.
323. Jaeger, E. E., R. E. Bontrop, and J. S. Lanchbury. 1993. Nucleotide sequences, polymorphism and gene deletion of T cell receptor beta-chain constant regions of Pan troglodytes and Macaca mulatta. J Immunol 151:5301-5309.
324. Jaeger, E. E., R. E. Bontrop, P. Parham, E. J. Wickings, M. Kadwell, and J. S. Lanchbury. 1998. Characterization of chimpanzee TCRV gene polymorphism: How old are human TCRV alleles? Immunogenetics 47:115-123.
325. Jamil, K. M., and S. I. Khakoo. 2011. KIR/HLA interactions and pathogen immunity. J Biomed Biotechnol 2011:298348.
326. Jayaraman, P., T. Zhu, L. Misher, D. Mohan, L. Kuller, P. Polacino, B. A. Richardson, H. Bielefeldt-Ohmann, D. Anderson, S. L. Hu, and N. L. Haigwood. 2007. Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. J Virol 81:822-834.
327. Johnson, P. R., D. C. Montefiori, S. Goldstein, T. E. Hamm, J. Zhou, S. Kitov, N. L. Haigwood, L. Misher, W. T. London, J. L. Gerin, A. Allison, R. H. Purcell, R. M. Chanock, and V. M. Hirsch. 1992. Inactivated wholevirus vaccine derived from a proviral DNA clone of simian immunodeficiency virus induces high levels of neutralizing antibodies and confers protection against heterologous challenge. P Natl Acad Sci USA 89:2175-2179.
328. Johnson, P. R., B. C. Schnepp, J. Zhang, M. J. Connell, S. M. Greene, E. Yuste, R. C. Desrosiers, and K. Reed Clark. 2009. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med 15:901-906.
329. Jones, S. M., H. Feldmann, U. Stroher, J. B. Geisbert, L. Fernando, A. Grolla, H. D. Klenk, N. J. Sullivan, V. E. Volchkov, E. A. Fritz, K. M. Daddario, L. E. Hensley, P. B. Jahrling, and T. W. Geisbert. 2005. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nat Med 11:786-790.
330. Kamili, S., V. Sozzi, G. Thompson, K. Campbell, C. M. Walker, S. Locarnini, and K. Krawczynski. 2009. Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model. Hepatology 49:1483-1491.
331. Kapikian, A. Z., R. H. Mitchell, R. M. Chanock, R. A. Shvedoff, and C. E. Stewart. 1969. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol 89:405-421.
332. Karron, R. A., P. F. Wright, R. B. Belshe, B. Thumar, R. Casey, F. Newman, F. P. Polack, V. B. Randolph, A. Deatly, J. Hackell, W. Gruber, B. R. Murphy, and P. L. Collins. 2005. Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants. J Infect Dis 191:1093-1104.
333. Keele, B. F., E. E. Giorgi, J. F. Salazar-Gonzalez, J. M. Decker, K. T. Pham, M. G. Salazar, C. Sun, T. Grayson, S. Wang, H. Li, X. Wei, C. Jiang, J. L. Kirchherr, F. Gao, J. A. Anderson, L. H. Ping, R. Swanstrom, G. D. Tomaras, W. A. Blattner, P. A. Goepfert, J. M. Kilby, M. S. Saag, E. L. Delwart, M. P. Busch, M. S. Cohen, D. C. Montefiori, B. F. Haynes, B. Gaschen, G. S. Athreya, H. . Lee, N. Wood, C. Seoighe, A. S. Perelson, T. Bhattacharya, B. T. Korber, B. H. Hahn, and G. M. Shaw. 2008. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. P Natl Acad Sci USA 105:7552- 7557.
334. Keele, B. F., J. H. Jones, K. A. Terio, J. D. Estes, R. S. Rudicell, M. L. Wilson, Y. Li, G. H. Learn, T. M. Beasley, J. Schumacher-Stankey, E. Wroblewski, A. Mosser, J. Raphael, S. Kamenya, E. V. Lonsdorf, D. A. Travis, T. Mlengeya, M. J. Kinsel, J. G. Else, G. Silvestri, J. Goodall, P. M. Sharp, G. M. Shaw, A. E. Pusey, and B. H. Hahn. 2009a. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature 460:515-519.
335. Keele, B. F., H. Li, G. H. Learn, P. Hraber, E. E. Giorgi, T. Grayson, C. Sun, Y. Chen, W. W. Yeh, N. L. Letvin, J. R. Mascola, G. J. Nabel, B. F. Haynes, T. Bhattacharya, A. S. Perelson, B. T. Korber, B. H. Hahn, and G. M. Shaw. 2009b. Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV- 1. J Exp Med 206:1117-1134.
336. Khakoo, S. I., C. L. Thio, M. P. Martin, C. R. Brooks, X. Gao, J. Astemborski, J. Cheng, J.J . Goedert, D. Vlahov, M. Hilgartner, S. Cox, A. M. Little, G. J. Alexander, M. E. Cramp, S. J. O'Brien, W. M. Rosenberg, D. L. Thomas, and M. Carrington. 2004. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305:872-874.
337. Kim, Y. J., and H. S. Lee. 2010. Increasing incidence of hepatitis A in Korean adults. Intervirology 53:10-14.
338. Kraft, Z., N. R. Derby, R. A. McCaffrey, R. Niec, W. M. Blay, N. L. Haigwood, E. Moysi, C. J. Saunders, T. Wrin, C.J . Petropoulos, M. J. McElrath, and L. Stamatatos. 2007. Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies. J Virol 81:6402-6411.
339. Krawczynski, K., M. J. Alter, D. L. Tankersley, M. Beach, B. H. Robertson, S. Lambert, G. Kuo, J. E. Spelbring, E. Meeks, S. Sinha, and D. A. Carson. 1996. Effect of immune globulin on the prevention of experimental hepatitis C virus infection. J Infect Dis 173:822-828.
340. Krugman, S. 1986. The Willowbrook hepatitis studies revisited: Ethical aspects. Rev Infect Dis 8:157-162.
341. Krugman, S., and J. P. Giles. 1972. The natural history of viral hepatitis. Can Med Assoc J 106 (Suppl):442-446.
342. Kulkarni, V., R. Jalah, B. Ganneru, C. Bergamaschi, C. Alicea, A. von Gegerfelt, V. Patel, G. M. Zhang, B. Chowdhury, K. E. Broderick, N. Y. Sardesai, A. Valentin, M. Rosati, B. K. Felber, and G. N. Pavlakis. 2010. Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques. Vaccine 29:6742-6754.
343. Kwon, H., and A. S. Lok. 2011. Hepatitis B therapy. Nat Rev Gastroenterol Hepatol 8:275-284.
344. Kwon, S. Y. 2009. Current status of liver diseases in Korea: Hepatitis A. Korean J Hepatol 15(Suppl 6):S7-S12.
345. Laguette, N., B. Sobhian, N. Casartelli, M. Ringeard, C. Chable-Bessia, E. Segeral, A. Yatim, S. Emiliani, O. Schwartz, and M. Benkirane. 2011. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474:654-657.
346. Landsteiner, K., and C. P. Miller. 1925. Serological studies on the blood of the primates: I. The differentiation of human and anthropoid bloods. J Exp Med 42:841-852.
347. Landsteiner, K., and A. S. Wiener. 1937. On the presence of M agglutinogens in the blood of monkeys. J Immunol 33:19-25.
348. Landsteiner, K., and A. S. Wiener. 1941. Studies on an agglutinogen (Rh) in human blood reacting with anti-rhesus sera and with human isoantibodies. J Exp Med 74:309-320.
349. Lanford, R. E., E. S. Hildebrandt-Eriksen, A. Petri, R. Persson, M. Lindow, M. E. Munk, S. Kauppinen, and H. Orum. 2010. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327:198-201.
350. Lanford, R. E., Z. Feng, D. Chavez, B. Guerra, K. M. Brasky, Y. Zhou, D. Yamane, A. S. Perelson, C. M. Walker, and S. M. Lemon. 2011. Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA. P Natl Acad Sci USA 108:11223-11228.
351. Lay, M. D., J. Petravic, S. N. Gordon, J. Engram, G. Silvestri, and M. P. Davenport. 2009. Is the gut the major source of virus in early simian immunodeficiency virus infection? J Virol 83:7517-7523.
352. Ledgerwood, J. E., P. Costner, N. Desai, L. Holman, M. E. Enama, G. Yamshchikov, S. Mulangu, Z. Hu, C. A. Andrews, R. A. Sheets, R. A. Koup, M. Roederer, R. Bailer, J. R. Mascola, M. G. Pau, N. J. Sullivan, J. Goudsmit, G. J. Nabel, and B. S. Graham. 2010. A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults. Vaccine 29:304-313.
353. Letvin, N. L. 1998. Progress in the development of an HIV-1 vaccine. Science 280:1875-1880.
354. Lewinsohn, D. M., I. S. Tydeman, M. Frieder, J. E. Grotzke, R. A. Lines, S. Ahmed, K. D. Prongay, S. L. Primack, L. M. Colgin, A. D. Lewis, and D. A. Lewinsohn. 2006. High resolution radiographic and fine immunologic definition of TB disease progression in the rhesus macaque. Microbes Infect 8:2587-2598.
355. Li, X., S. Kamili, and K. Krawczynski. 2006. Quantitative detection of hepatitis E virus RNA and dynamics of viral replication in experimental infection. J Viral Hepat 13:835-839.
356. Li, Y., S. A. Migueles, B. Welcher, K. Svehla, A. Phogat, M. K. Louder, X. Wu, G. M. Shaw, M. Connors, R. T. Wyatt, and J. R. Mascola. 2007. Broad HIV-1 neutralization mediated by CD4-binding site antibodies. Nat Med 13:1032-1034.
357. Lienert, K., and P. Parham. 1996. Evolution of MHC class I genes in higher primates. Immunol Cell Biol 74:349-356.
358. Lifson, J. D., and N. L. Haigwood. In press. Lessons in non-human primate models for AIDS vaccine Research: From minefields to milestones. In CSH Perspectives. G. Nabel and F. Bushman, editors. New York: Cold Spring Harbor Press.
359. Lifson, J. D., M. Piatak, Jr., J. L. Rossio, J. Bess, Jr., E. Chertova, D. Schneider, R. Kiser, V. Coalter, B. Poore, R. Imming, R. C. Desrosiers, L. E. Henderson, and L. O. Arthur. 2002. Whole inactivated SIV virion vaccines with functional envelope glycoproteins: Safety, immunogenicity, and activity against intrarectal challenge. J Med Primatol 31:205-216.
360. Lim, E. S., H. S. Malik, and M. Emerman. 2010. Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses. J Virol 84:7124-7134.
361. Lin, P. L., and J. L. Flynn. 2010. Understanding latent tuberculosis: A moving target. J Immunol 185:15-22.
362. Loffredo, J. T., A. T. Bean, D. R. Beal, E. J. Leon, G. E. May, S. M. Piaskowski, J. R. Furlott, J. Reed, S. K. Musani, E. G. Rakasz, T. C. Friedrich, N. A. Wilson, D. B. Allison, and D. I. Watkins. 2008. Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication. J Virol 82:1723-1738.
363. Loffredo, J. T., J. Sidney, A. T. Bean, D. R. Beal, W. Bardet, A. Wahl, O. E. Hawkins, S. Piaskowski, N. A. Wilson, W. H. Hildebrand, D. I. Watkins, and A. Sette. 2009. Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLAB* 2705, bind peptides with sequence similarity. J Immunol 182:7763-7775.
364. Mahalanabis, M., P. Jayaraman, T. Miura, F. Pereyra, E. M. Chester, B. Richardson, B. Walker, and N. L. Haigwood. 2009. Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllers. J Virol 83:662-672.
365. Malherbe, D. C., N. A. Doria-Rose, L. Misher, T. Beckett, W. B. Puryear, J. T. Schuman, Z. Kraft, J. O'Malley, M. Mori, I. Srivastava, S. Barnett, L. Stamatatos, and N. L. Haigwood. 2011. Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies. J Virol 85:5262-5274.
366. Marthas, M. L., K. K. A. Van Rompay, M. Otsyula, C. J. Miller, D. R. Canfield, N. C. Pedersen, and M. B. McChesney. 1995. Viral factors determine progression to AIDS in simian immunodeficiency virus-infected newborn rhesus macaques. J Virol 69:4198-4205.
367. Mattila, J. T., C. R. Diedrich, P. L. Lin, J. Phuah, and J. L. Flynn. 2011. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol 186:3527-3537.
368. Maynard, J. E., K. R. Berquist, W. V. Hartwell, and D. H. Krushak. 1972a. Viral hepatitis and studies of hepatitis associated antigen in chimpanzees. Can Med Assoc J 106(Suppl):473-479.
369. Maynard, J. E., K. R. Berquist, D. H. Krushak, and R. H. Purcell. 1972b. Experimental infection of chimpanzees with the virus of hepatitis B. Nature 237:514-515.
370. Maynard, J. E., D. H. Krushak, D. W. Bradley, and K. R. Berquist. 1975. Infectivity studies of hepatitis A and B in non-human primates. Dev Biol Stand 30:229-235.
371. McAleer, W. J., E. B. Buynak, R. Z. Maigetter, D. E. Wampler, W. J. Miller, and M. R. Hilleman. 1984. Human hepatitis B vaccine from recombinant yeast. Nature 307:178-180.
372. McCaustland, K. A., K. Krawczynski, J. W. Ebert, M. S. Balayan, A. G. Andjaparidze, J. E. Spelbring, E. H. Cook, C. Humphrey, P. O. Yarbough, M. O. Favorov, D. Carson, D. W. Bradley, and B. H. Robertson. 2000. Hepatitis E virus infection in chimpanzees: A retrospective analysis. Arch Virol 145:1909- 1918.
373. McChesney, M. B., C. J. Miller, P. A. Rota, Y. D. Zhu, L. Antipa, N. W. Lerche, R. Ahmed, and W. J. Bellini. 1997. Experimental measles. I. Pathogenesis in the normal and the immunized host. Virology 233:74-84.
374. McMahan, R. H., L. Golden-Mason, M. I. Nishimura, B. J. McMahon, M. Kemper, T. M. Allen, D. R. Gretch, and H. R. Rosen. 2010. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest 120:4546-4557.
375. Messaoudi, I., J. Warner, M. Fischer, B. Park, B. Hill, J. Mattison, M. A. Lane, G. S. Roth, D. K. Ingram, L. J. Picker, D. C. Douek, M. Mori, and J. Nikolich-Zugich. 2006. Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. P Natl Acad Sci USA 103:19448- 19453.
376. Messaoudi, I., B. Damania, and S. W. Wong. 2008. Primate models for gammaherpesvirus-associated malignancies. In DNA Tumor Viruses. B. Damania and J. Pipas, editors. Springer Science+Business Media LLC.
377. Messaoudi, I., A. Barron, M. Wellish, F. Engelmann, A. Legasse, S. Planer, D. Gilden, J. Nikolich-Zugich, and R. Mahalingam. 2009. Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans. PLoS pathogens 5:e1000657.
378. Messaoudi, I., R. Estep, B. Robinson, and S. W. Wong. 2011. Nonhuman primate models of human immunology. Antioxid Redox Signal 14:261-273.
379. Meyer-Olson, D., K. W. Brady, J. T. Blackard, T. M. Allen, S. Islam, N. H. Shoukry, K. Hartman, C. M. Walker, and S. A. Kalams. 2003. Analysis of the TCR beta variable gene repertoire in chimpanzees: Identification of functional homologs to human pseudogenes. J Immunol 170:4161-4169.
380. Meyer-Olson, D., N. H. Shoukry, K. W. Brady, H. Kim, D. P. Olson, K. Hartman, A. K. Shintani, C. M. Walker, and S. A. Kalams. 2004. Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. J Exp Med 200:307-319.
381. Mikkelsen, T. S., L. W. Hillier, E. E. Eichler, M. C. Zody, D. B. Jaffe, S.-P. Yang, W. Enard, I. Hellmann, K. Lindblad-Toh, T. K. Altheide, N. Archidiacono, P. Bork, J. Butler, J. L. Chang, Z. Cheng, A. T. Chinwalla, P. deJong, K. D. Delehaunty, C. C. Fronick, L. L. Fulton, Y. Gilad, G. Glusman, S. Gnerre, T. A. Graves, T. Hayakawa, K. E. Hayden, X. Huang, H. Ji, W. J. Kent, M.-C. King, E. J. Kulbokas III, M. K. Lee, G. Liu, C. Lopez-Otin, K. D. Makova, O. Man, E. R. Mardis, E. Mauceli, T. L. Miner, W. E. Nash, J. O. Nelson, S. Pääbo, N. J. Patterson, C. S. Pohl, K. S. Pollard, K. Prüfer, X. S. Puente, D. Reich, M. Rocchi, K. Rosenbloom, M. Ruvolo, D. J. Richter, S. F. Schaffner, A. F. A. Smit, S. M. Smith, M. Suyama, J. Taylor, D. Torrents, E. Tuzun, A. Varki, G. Velasco, M. Ventura, J. W. Wallis, M. C. Wendl, R. K. Wilson, E. S. Lander, and R. H. Waterston. 2005. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437(7055):69-87.
382. Milush, J. M., D. Kosub, M. Marthas, K. Schmidt, F. Scott, A. Wozniakowski, C. Brown, S. Westmoreland, and D. L. Sodora. 2004. Rapid dissemination of SIV following oral inoculation. AIDS 18:2371-2380.
383. Miyoshi-Akiyama, T., I. Ishida, M. Fukushi, K. Yamaguchi, Y. Matsuoka, T. Ishihara, M. Tsukahara, S. Hatakeyama, N. Itoh, A. Morisawa, Y. Yoshinaka, N. Yamamoto, Z. Lianfeng, Q. Chuan, T. Kirikae, and T. Sasazuki. 2011. Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model. J Infect Dis 203:1574-1581.
384. Mizukoshi, E., M. Nascimbeni, J. B. Blaustein, K. Mihalik, C. M. Rice, T. J. Liang, S. M. Feinstone, and B. Rehermann. 2002. Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune response and vaccination studies. J Virol 76:6093-6103.
385. Monath, T. P., K. R. Brinker, F. W. Chandler, G. E. Kemp, and C. B. Cropp. 1981. Pathophysiologic correlations in a rhesus monkey model of yellow fever with special observations on the acute necrosis of B cell areas of lymphoid tissues. Am J Trop Med Hyg 30:431-443.
386. Moore, P. L., E. S. Gray, D. Sheward, M. Madiga, N. Ranchobe, Z. Lai, W. J. Honnen, M. Nonyane, N. Tumba, T. Hermanus, S. Sibeko, K. Mlisana, S. S. Abdool Karim, C. Williamson, A. Pinter, and L. Morris. 2011. Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop. J Virol 85:3128-3141.
387. Moreland, A. J., L. A. Guethlein, R. K. Reeves, K. W. Broman, R. P. Johnson, P. Parham, D. H. O'Connor, and B. N. Bimber. 2011. Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques. BMC Genomics 12:295.
388. Morgan, C., M. Marthas, C. Miller, A. Duerr, C. Cheng-Mayer, R. Desrosiers, J. Flores, N. Haigwood, S. L. Hu, R. P. Johnson, J. Lifson, D. Montefiori, J. Moore, M. Robert-Guroff, H. Robinson, S. Self, and L. Corey. 2008. The use of nonhuman primate models in HIV vaccine development. PLoS Med 5:e173.
389. Mukherjee, S., N. Sarkar-Roy, D. K. Wagener, and P. P. Majumder. 2009. Signatures of natural selection are not uniform across genes of innate immune system, but purifying selection is the dominant signature. P Natl Acad Sci USA 106:7073-7078.
390. Nair, H., D. J. Nokes, B. D. Gessner, M. Dherani, S. A. Madhi, R. J. Singleton, K. L. O'Brien, A. Roca, P. F. Wright, N. Bruce, A. Chandran, E. Theodoratou, A. Sutanto, E. R. Sedyaningsih, M. Ngama, P. K. Munywoki, C. Kartasasmita, E. A. Simoes, I. Rudan, M. W. Weber, and H. Campbell. 2010. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis. Lancet 375:1545-1555.
391. Nakamoto, N., H. Cho, A. Shaked, K. Olthoff, M. E. Valiga, M. Kaminski, E. Gostick, D. A. Price, G. J. Freeman, E. J. Wherry, and K. M. Chang. 2009. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog 5:e1000313.
392. Nara, P. L., W. G. Robey, L. O. Arthur, D. M. Asher, A. V. Wolff, Gibbs, C., Jr., C. D. Gajdusek, and P. J. Fischinger. 1987. Persistent infection of chimpanzees with human immunodeficiency virus: Serological responses and properties of reisolated viruses. J Virol 61:3173-3180.
393. Nguitragool, W., A. A. Bokhari, A. D. Pillai, K. Rayavara, P. Sharma, B. Turpin, L. Aravind, and S. A. Desai. 2011. Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells. Cell 145:665-677.
394. Nichols, H. J. 1914. Observations on experimental typhoid infection of the gall bladder in the rabbit. J Exp Med 20:573-581.
395. Novembre, G. J., M. Saucier, D. C. Anderson, S. A. Klumpp, S. P. O'Neil, C. R. I. Brown, C. E. Hart, P. C. Guenthner, R. B. Swenson, and H. M. McClure. 1997. Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1. J Virol 71:4086-4091.
396. Okoye, A., H. Park, M. Rohankhedkar, L. Coyne-Johnson, R. Lum, J. M. Walker, S. L. Planer, A. W. Legasse, A. W. Sylwester, M. Piatak, Jr., J. D. Lifson, D. L. Sodora, F. Villinger, M. K. Axthelm, J. E. Schmitz, and L. J. Picker. 2009. Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med 206:1575-1588.
397. Olsen, D. B., M. E. Davies, L. Handt, K. Koeplinger, N. R. Zhang, S. W. Ludmerer, D. Graham, N. Liverton, M. MacCoss, D. Hazuda, and S. S. Carroll. 2011. Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents. Antimicrob Agents Chemother 55:937-939.
398. Onlamoon, N. ,S. Noisakran, H. M. Hsiao, A. Duncan, F. Villinger, A. A. Ansari, and G. C. Perng. 2010. Dengue virus-induced hemorrhage in a nonhuman primate model. Blood 115:1823-1834.
399. Otting, N., A. J. de Vos-Rouweler, C. M. Heijmans, N. G. de Groot, G. G. Doxiadis, and R. E. Bontrop. 2007. MHC class I A region diversity and polymorphism in macaque species. Immunogenetics 59:367-375.
400. Pal, R., D. Venzon, N. L. Letvin, S. Santra, D. C. Montefiori, N. R. Miller, E. Tryniszewska, M. G. Lewis, T. C. VanCott, V. Hirsch, R. Woodward, A. Gibson, M. Grace, E. Dobratz, P. D. Markham, Z. Hel, J. Nacsa, M. Klein, J. Tartaglia, and G. Franchini. 2002. ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency. J Virol 76:292-302.
401. Pal, R., D. Venzon, S. Santra, V. S. Kalyanaraman, D. C. Montefiori, L. Hocker, L. Hudacik, N. Rose, J. Nacsa, Y. Edghill-Smith, M. Moniuszko, Z. Hel, I. M. Belyakov, J. A. Berzofsky, R. W. Parks, P. D. Markham, N. L. Letvin, J. Tartaglia, and G. Franchini. 2006. Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simianhuman immunodeficiency virus SHIVKU2 RNA levels. J Virol 80:3732- 3742.
402. Pandrea, I., C. Apetrei, J. Dufour, N. Dillon, J. Barbercheck, M. Metzger, B. Jacquelin, R. Bohm, P. A. Marx, F. Barre-Sinoussi, V. M. Hirsch, M. C. Muller-Trutwin, A. A. Lackner, and R. S. Veazey. 2006. Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts. J Virol 80:4858-4867.
403. Pandrea, I., C. Apetrei, S. Gordon, J. Barbercheck, J. Dufour, R. Bohm, B. Sumpter, P. Roques, P. A. Marx, V. M. Hirsch, A. Kaur, A. A. Lackner, R. S. Veazey, and G. Silvestri. 2007. Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts. Blood 109:1069-1076.
404. Parham, P. 2005. MHC class I molecules and KIRs in human history, health and survival. Nature Rev Immunol 5:201-214.
405. Parham, P. 2008. The genetic and evolutionary balances in human NK cell receptor diversity. Semin Immunol 20:311-316.
406. Parham, P., L. Abi-Rached, L. Matevosyan, A. K. Moesta, P. J. Norman, A. M. Older Aguilar, and L. A. Guethlein. 2010. Primate-specific regulation of natural killer cells. Journal Med Primatol 39:194-212.
407. Patel, V., A. Valentin, V. Kulkarni, M. Rosati, C. Bergamaschi, R. Jalah, C. Alicea, J. T. Minang, M. T. Trivett, C. Ohlen, J. Zhao, M. Robert-Guroff, A. S. Khan, R. Draghia-Akli, B. K. Felber, and G. N. Pavlakis. 2010. Longlasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization. Vaccine 28:4827-4836.
408. Patterson, L. J., N. Malkevitch, J. Pinczewski, D. Venzon, Y. Lou, B. Peng, C. Munch, M. Leonard, E. Richardson, K. Aldrich, V. S. Kalyanaraman, G. N. Pavlakis, and M. Robert-Guroff. 2003. Potent, persistent induction and modulation of cellular immune responses in rhesus macaques primed with Ad5hr-simian immunodeficiency virus (SIV) env/rev, gag, and/or nef vaccines and boosted with SIV gp120. J Virol 77:8607-8620.
409. Penna, A., M. Pilli, A. Zerbini, A. Orlandini, S. Mezzadri, L. Sacchelli, G. Missale, and C. Ferrari. 2007. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology 45:588-601.
410. Permar, S. R., S. A. Klumpp, K. G. Mansfield, W. K. Kim, D. A. Gorgone, M. A. Lifton, K. C. Williams, J. E. Schmitz, K. A. Reimann, M. K. Axthelm, F. P. Polack, D. E. Griffin, and N. L. Letvin. 2003. Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys. J Virol 77:4396-4400.
411. Permar, S. R., S. A. Klumpp, K. G. Mansfield, A. A. Carville, D. A. Gorgone, M. A. Lifton, J. E. Schmitz, K. A. Reimann, F. P. Polack, D. E. Griffin, and N. L. Letvin. 2004. Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys. J Infect Dis 190:998-1005.
412. Permar, S. R., S. S. Rao, Y. Sun, S. Bao, A. P. Buzby, H. H. Kang, and N. L. Letvin. 2007. Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. J Infect Dis 196:1784-1793.
413. Pitcher, C. J., S. I. Hagen, J. M. Walker, R. Lum, B. L. Mitchell, V. C. Maino, M. K. Axthelm, and L. J. Picker. 2002. Development and homeostasis of T cell memory in rhesus macaque. J Immunol 168:29-43.
414. Polacino, P., K. Larsen, L. Galmin, J. Suschak, Z. Kraft, L. Stamatatos, D. Anderson, S. W. Barnett, R. Pal, K. Bost, A. H. Bandivdekar, C. J. Miller, and S. L. Hu. 2008. Differential pathogenicity of SHIV infection in pig-tailed and rhesus macaques. J Med Primatol 37(Suppl 2):13-23.
415. Poland, J. D., C. H. Calisher, T. P. Monath, W. G. Downs, and K. Murphy. 1981. Persistence of neutralizing antibody 30-35 years after immunization with 17D yellow fever vaccine. B World Health Org 59:895-900.
416. Porter, D. W., F. M. Thompson, T. K. Berthoud, C. L. Hutchings, L. Andrews, S. Biswas, I. Poulton, E. Prieur, S. Correa, R. Rowland, T. Lang, J. Williams, S. C. Gilbert, R. E. Sinden, S. Todryk, and A. V. Hill. 2011. A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine. Vaccine 29:7514-7522.
417. Price, D. A., A. D. Bitmansour, J. B. Edgar, J. M. Walker, M. K. Axthelm, D. C. Douek, and L. J. Picker. 2008. Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques. J Immunol 180:269-280.
418. Prince, A. M., and L. Andrus. 1998. AIDS vaccine trials in chimpanzees. Science 282:2195-2196.
419. Prince, A. M., B. Brotman, G. F. Grady, W. J. Kuhns, C. Hazzi, R. W. Levine, and S. J. Millian. 1974. Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus. Lancet 2:241-246.
420. Prince, A. M., D. Pascual, L. B. Kosolapov, D. Kurokawa, L. Baker, and P. Rubinstein. 1987. Prevalence, clinical significance, and strain specificity of neutralizing antibody to the human immunodeficiency virus. J Infect Dis 156:268-272.
421. Prince, A. M., H. Reesink, D. Pascual, B. Horowitz, I. Hewlett, K. K. Murthy, K. E. Cobb, and J. Eichberg. 1991. Prevention of HIV infection by passive immunization with HIV immunoglobulin. AIDS Res Hum Retrov 7:971- 973.
422. Prince, A. M., B. Brotman, T. Huima, D. Pascual, M. Jaffery, and G. Inchauspe. 1992. Immunity in hepatitis C infection. J Infect Dis 165:438-443.
423. Provost, P. J., P. A. Conti, P. A. Giesa, F. S. Banker, E. B. Buynak, W. J. McAleer, and M. R. Hilleman. 1983. Studies in chimpanzees of live, attenuated hepatitis A vaccine candidates. Proc Soc Exp Biol Med 172:357- 363.
424. Pulendran, B., J. Miller, T. D. Querec, R. Akondy, N. Moseley, O. Laur, J. Glidewell, N. Monson, T. Zhu, H. Zhu, S. Staprans, D. Lee, M. A. Brinton, A. A. Perelygin, C. Vellozzi, P. Brachman, Jr., S. Lalor, D. Teuwen, R. B. Eidex, M. Cetron, F. Priddy, C. del Rio, J. Altman, and R. Ahmed. 2008. Case of yellow fever vaccine-associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes. J Infect Dis 198:500-507.
425. Purcell, R. H., and J. L. Gerin. 1975. Hepatitis B subunit vaccine: A preliminary report of safety and efficacy tests in chimpanzees. Am J Med Sci 270:395- 399.
426. Purcell, R. H., E. D'Hondt, R. Bradbury, S. U. Emerson, S. Govindarajan, and L. Binn. 1992. Inactivated hepatitis A vaccine: Active and passive immunoprophylaxis in chimpanzees. Vaccine 10(Suppl 1):S148-S151.
427. Querec, T. D., R. S. Akondy, E. K. Lee, W. Cao, H. I. Nakaya, D. Teuwen, A. Pirani, K. Gernert, J. Deng, B. Marzolf, K. Kennedy, H. Wu, S. Bennouna, H. Oluoch, J. Miller, R.Z. Vencio, M. Mulligan, A. Aderem, R. Ahmed, and B. Pulendran. 2009. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat Immunol 10:116-125.
428. Raziorrouh, B., W. Schraut, T. Gerlach, D. Nowack, N. H. Gruner, A. Ulsenheimer, R. Zachoval, M. Wachtler, M. Spannagl, J. Haas, H. M. Diepolder, and M. C. Jung. 2010. The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virusspecific CD8+ T-cell function. Hepatology 52:1934-1947.
429. Reeves, R. K., J. Gillis, F. E. Wong, Y. Yu, M. Connole, and R. P. Johnson. 2010. CD16- natural killer cells: Enrichment in mucosal and secondary lymphoid tissues and altered function during chronic SIV infection. Blood 115:4439-4446.
430. Reeves, R. K., P. A. Rajakumar, T. I. Evans, M. Connole, J. Gillis, F. E. Wong, Y. V. Kuzmichev, A. Carville, and R. P. Johnson. 2011. Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection. Blood 118:3321-3330.
431. Rehermann, B. 2009. Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence. J Clin Invest 119:1745- 1754.
432. Reimann, K. A., J. T. Li, R. Veazey, M. Halloran, I. W. Park, G. B. Karlsson, J. Sodroski, and N. L. Letvin. 1996. A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys. J Virol 70:6922-6928.
433. Rerks-Ngarm, S., P. Pitisuttithum, S. Nitayaphan, J. Kaewkungwal, J. Chiu, R. Paris, N. Premsri, C. Namwat, M. de Souza, E. Adams, M. Benenson, S. Gurunathan, J. Tartaglia, J. G. McNeil, D. P. Francis, D. Stablein, D. L. Birx, S. Chunsuttiwat, C. Khamboonruang, P. Thongcharoen, M. L. Robb, N. L. Michael, P. Kunasol, and J. H. Kim. 2009. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 361:2209-2220.
434. Rhee, E. G., and D. H. Barouch. 2009. Translational Mini-Review Series on Vaccines for HIV: Harnessing innate immunity for HIV vaccine development. Clin Exp Immunol 157:174-180.
435. Rijckborst, V., M. J. Sonneveld, and H. L. Janssen. 2011. Review article: Chronic hepatitis B-anti-viral or immunomodulatory therapy? Aliment Pharmacol Ther 33:501-513.
436. Rizzetto, M., M. G. Canese, R. H. Purcell, W. T. London, L. D. Sly, and J. L. Gerin. 1981. Experimental HBV and delta infections of chimpanzees: Occurrence and significance of intrahepatic immune complexes of HBcAg and delta antigen. Hepatology 1:567-574.
437. Robinson, J. E., K. S. Cole, D. H. Elliott, H. Lam, A. M. Amedee, R. Means, R. C. Desrosiers, J. Clements, R. C. Montelaro, and M. Murphey-Corb. 1998. Production and characterization of SIV envelope-specific rhesus monoclonal antibodies from a macaque asymptomatically infected with a live SIV vaccine. AIDS Res Hum Retrov 14:1253-1262.
438. Rosati, M., A. von Gegerfelt, P. Roth, C. Alicea, A. Valentin, M. Robert-Guroff, D. Venzon, D. C. Montefiori, P. Markham, B. K. Felber, and G. N. Pavlakis. 2005. DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge. J Virol 79:8480-8492.
439. Rudensey, L. M., J. T. Kimata, E. M. Long, B. Chackerian, and J. Overbaugh. 1998. Changes in the extracellular envelope glycoprotein of variants that evolve during the course of simian immunodeficiency virus SIVMne infection affect neutralizing antibody recognition, syncytium formation and macrophage tropism, but not replication, cytopathicity or CCR-5 coreceptor recognition. J Virol 72:209-217.
440. Sa, J. M., O. Twu, K. Hayton, S. Reyes, M. P. Fay, P. Ringwald, and T. E. Wellems. 2009. Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine. P Natl Acad Sci USA 106:18883-18889.
441. Sabatini, M. J., P. Ebert, D. A. Lewis, P. Levitt, J. L. Cameron, and K. Mirnics. 2007. Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation. J Neurosci 27:3295-3304.
442. Sambrook, J. G., A. Bashirova, H. Andersen, M. Piatak, G. S. Vernikos, P. Coggill, J. D. Lifson, M. Carrington, and S. Beck. 2006. Identification of the ancestral killer immunoglobulin-like receptor gene in primates. BMC Genomics 7:209.
443. Sarma, S. V., U. T. Eden, M. L. Cheng, Z. M. Williams, R. Hu, E. Eskandar, and E. N. Brown. 2010. Using point process models to compare neural spiking activity in the subthalamic nucleus of Parkinson's patients and a healthy primate. IEEE T Bio-med Eng 57:1297-1305.
444. Sather, D. N., J. Armann, L. K. Ching, A. Mavrantoni, G. Sellhorn, Z. Caldwell, X. Yu, B. Wood, S. Self, S. Kalams, and L. Stamatatos. 2009. Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection. J Virol 83:757-769.
445. Sauter, D., M. Schindler, A. Specht, W. N. Landford, J. Munch, K. A. Kim, J. Votteler, U. Schubert, F. Bibollet-Ruche, B. F. Keele, J. Takehisa, Y. Ogando, C. Ochsenbauer, J. C. Kappes, A. Ayouba, M. Peeters, G. H. Learn, G. Shaw, P. M. Sharp, P. Bieniasz, B. H. Hahn, T. Hatziioannou, and F. Kirchhoff. 2009. Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains. Cell Host Microbe 6:409-421.
446. Schatten, G., and S. Mitalipov. 2009. Developmental biology: Transgenic primate offspring. Nature 459:515-516.
447. Schmitz, J. E., M. J. Kuroda, S. Santra, V. G. Sasseville, M. A. Simon, M. A. Lifton, P. Racz, K. Tenner-Racz, M. Dalesandro, B. J. Scallon, J. Ghrayeb, M. A. Forman, D. C. Montefiori, E. P. Rieber, N. L. Letvin, and K. A. Reimann. 1999. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283:857-860.
448. Schmitz, J. E., M. J. Kuroda, S. Santra, M. A. Simon, M. A. Lifton, W. Lin, R. Khunkhun, M. Piatak, J. D. Lifson, G. Grosschupff, R. S. Gelman, P. Racz, K. Tenner-Racz, K. A. Mansfield, N. L. Letvin, D. C. Montefiori, and K. A. Reimann. 2003. Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol 77:2165-2173.
449. Schmokel, J., H. Li, E. Bailes, M. Schindler, G. Silvestri, B. H. Hahn, C. Apetrei, and F. Kirchhoff. 2009. Conservation of Nef function across highly diverse lineages of SIVsmm. Retrovirology 6:36.
450. Scinicariello, F., C. N. Engleman, L. Jayashankar, H. M. McClure, and R. Attanasio. 2004. Rhesus macaque antibody molecules: Sequences and heterogeneity of alpha and gamma constant regions. Immunology 111:66- 74.
451. Shiver, J. W., T. M. Fu, L. Chen, D. R. Casimiro, M. E. Davies, R. K. Evans, Z. Q. Zhang, A. J. Simon, W. L. Trigona, S. A. Dubey, L. Huang, V. A. Harris, R. S. Long, X. Liang, L. Handt, W. A. Schleif, L. Zhu, D. C. Freed, N. V. Persaud, L. Guan, K. S. Punt, A. Tang, M. Chen, K. A. Wilson, K. B. Collins, G. J. Heidecker, V. R. Fernandez, H. C. Perry, J. G. Joyce, K. M. Grimm, J. C. Cook, P. M. Keller, D. S. Kresock, H. Mach, R. D. Troutman, L. A. Isopi, D. M. Williams, Z. Xu, K. E. Bohannon, D. B. Volkin, D. C. Montefiori, A. Miura, G. R. Krivulka, M. A. Lifton, M. J. Kuroda, J. E. Schmitz, N. L. Letvin, M. J. Caulfield, A. J. Bett, R. Youil, D. C. Kaslow, and E. A. Emini. 2002. Replication-incompetent adenoviral vaccine vector elicits effective antiimmunodeficiency- virus immunity. Nature 415:331-335.
452. Shoukry, N. H., A. Grakoui, M. Houghton, D. Y. Chien, J. Ghrayeb, K. A. Reimann, and C. M. Walker. 2003. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 197:1645-1655.
453. Shrestha, M. P., R. M. Scott, D. M. Joshi, M. P. Mammen, Jr., G. B. Thapa, N. Thapa, K. S. Myint, M. Fourneau, R. A. Kuschner, S. K. Shrestha, M. P. David, J. Seriwatana, D. W. Vaughn, A. Safary, T. P. Endy, and B. L. Innis. 2007. Safety and efficacy of a recombinant hepatitis E vaccine. N Engl J Med 356:895-903.
454. Sidney, J., S. Asabe, B. Peters, K. A. Purton, J. Chung, T. J. Pencille, R. Purcell, C. M. Walker, F. V. Chisari, and A. Sette. 2006. Detailed characterization of the peptide binding specificity of five common Patr class I MHC molecules. Immunogenetics 58:559-570. Silvestri, G. 2009. Immunity in natural SIV infections. J Intern Med 265:97-109.
455. Silvestri, G. 2009. Immunity in natural SIV infections. J Intern Med 265:97-109
456. Smirnova, I., A. Poltorak, E. K. Chan, C. McBride, and B. Beutler. 2000. Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biol 1:RESEARCH002.
457. Smit-McBride, Z., J. J. Mattapallil, M. McChesney, D. Ferrick, and S. Dandekar. 1998. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. J Virol 72:6646-6656.
458. Smith, L. R., M. K. Wloch, M. Ye, L. R. Reyes, S. Boutsaboualoy, C. E. Dunne, J. A. Chaplin, D. Rusalov, A. P. Rolland, C. L. Fisher, M. S. Al-Ibrahim, M. L. Kabongo, R. Steigbigel, R. B. Belshe, E. R. Kitt, A. H. Chu, and R. B. Moss. 2010. Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin. Vaccine 28:2565-2572.
459. Smits, S. L., A. de Lang, J. M. van den Brand, L. M. Leijten, I. W. F. van, M. J. Eijkemans, G. van Amerongen, T. Kuiken, A. C. Andeweg, A. D. Osterhaus, and B. L. Haagmans. 2010. Exacerbated innate host response to SARS-CoV in aged non-human primates. PLoS pathogens 6:e1000756.
460. Soderstrom, K., J. O'Malley, K. Steece-Collier, and J. H. Kordower. 2006. Neural repair strategies for Parkinson's disease: Insights from primate models. Cell Transplant 15:251-265.
461. Sodora, D. L., C. J. Miller, and P. A. Marx. 1997. Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks. AIDS Res Hum Retrov 13:S1-S5.
462. Sodora, D. L., J. S. Allan, C. Apetrei, J. M. Brenchley, D. C. Douek, J. G. Else, J. D. Estes, B. H. Hahn, V. M. Hirsch, A. Kaur, F. Kirchhoff, M. Muller- Trutwin, I. Pandrea, J. E. Schmitz, and G. Silvestri. 2009. Toward an AIDS vaccine: Lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nat Med 15:861-865.
463. St Gelais, C., and L. Wu. 2011. SAMHD1: A new insight into HIV-1 restriction in myeloid cells. Retrovirology 8:55.
464. Stevens, H. E., J. F. Leckman, J. D. Coplan, and S. J. Suomi. 2009. Risk and resilience: Early manipulation of macaque social experience and persistent behavioral and neurophysiological outcomes. J Am Acad Child Ps 48:114- 127.
465. Sullivan, N. J., A. Sanchez, P. E. Rollin, Z. Y. Yang, and G. J. Nabel. 2000. Development of a preventive vaccine for Ebola virus infection in primates. Nature 408:605-609.
466. Sullivan, N. J., T. W. Geisbert, J. B. Geisbert, L. Xu, Z. Y. Yang, M. Roederer, R. A. Koup, P. B. Jahrling, and G. J. Nabel. 2003. Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. Nature 424:681-684.
467. Sullivan, N. J., T. W. Geisbert, J. B. Geisbert, D. J. Shedlock, L. Xu, L. Lamoreaux, J. H. Custers, P. M. Popernack, Z. Y. Yang, M. G. Pau, M. Roederer, R. A. Koup, J. Goudsmit, P. B. Jahrling, and G. J. Nabel. 2006. Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs. PLoS Med 3:e177.
468. Sullivan, N. J., J. E. Martin, B. S. Graham, and G. J. Nabel. 2009. Correlates of protective immunity for Ebola vaccines: Implications for regulatory approval by the animal rule. Nature Rev Micro 7:393-400.
469. Tabor, E., R. J. Gerety, J. A. Drucker, L. B. Seeff, J.H. Hoofnagle, D. R. Jackson, M. April, L. F. Barker, and G. Pineda-Tamondong. 1978. Transmission of non-A, non-B hepatitis from man to chimpanzee. Lancet 1:463-466.
470. Tachibana, M., M. Sparman, H. Sritanaudomchai, H. Ma, L. Clepper, J. Woodward, Y. Li, C. Ramsey, O. Kolotushkina, and S. Mitalipov. 2009. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature 461:367-372.
471. Teng, M. N., S. S. Whitehead, A. Bermingham, M. St Claire, W. R. Elkins, B. R. Murphy, and P. L. Collins. 2000. Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees. J Virol 74:9317-9321.
472. Thimme, R., D. Oldach, K. M. Chang, C. Steiger, S. C. Ray, and F. V. Chisari. 2001. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194:1395-1406.
473. Thimme, R., J. Bukh, H. C. Spangenberg, S. Wieland, J. Pemberton, C. Steiger, S. Govindarajan, R. H. Purcell, and F. V. Chisari. 2002. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. P Natl Acad Sci USA 99:15661-15668.
474. Thimme, R., S. Wieland, C. Steiger, J. Ghrayeb, K. A. Reimann, R. H. Purcell, and F. V. Chisari. 2003. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 77:68-76.
475. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. J. Dwarki, S. H. Gromkowski, R. R. Deck, C. M. EdWitt, A. Friedman, L. A. Hawe, K. R. Leander, D. Mrtinex, H. C. Perry, J. W. Shiver, D. L. Mongomery, and M. A. Liu. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745- 1749.
476. Vaine, M., S. Wang, E. T. Crooks, P. Jiang, D. C. Montefiori, J. Binley, and S. Lu. 2008. Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA primeprotein boost vaccination compared to gp120 protein-only vaccination. J Virol 82:7369-7378.
477. van Montfort, T., M. Melchers, G. Isik, S. Menis, P. S. Huang, K. Matthews, E. Michael, B. Berkhout, W. R. Schief, J. P. Moore, and R. W. Sanders. 2011. A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses. J Biol Chem 286:22250- 22261.
478. Van Rompay, K. K. A. , and N. L. Haigwood. 2008. Pediatric AIDS: Maternalfetal and maternal-infant transmission of lentiviruses and effects on infant development in nonhuman primates. In Primate Models of Children's Health and Developmental Disabilities. T. M. Burbacher, G. P. Sackett, and K. S. Grant, editors. Amsterdam: Academic Press.
479. VandeBerg, J. L., S. M. Zola, J. J. Ely, and R. C. Kennedy. 2006. Monoclonal antibody testing. J Med Primatol 35:405-406.
480. Vierboom, M., and B. 't Hart. 2008. Spontaneous and experimentally induced autoimmune diseases in nonhuman primates. In Primate Models of Children's Health and Developmental Disabilities. T. Burbacher, G. Sackett, and K. Grant, editors. New York: Academic Press. Pp. 71-107.
481. Voytko, M. L., and G. P. Tinkler. 2004. Cognitive function and its neural mechanisms in nonhuman primate models of aging, Alzheimer disease, and menopause. Frontiers in Bioscience: A Journal and Virtual Library 9:1899- 1914.
482. Walker, C. M. 2010. Adaptive immunity to the hepatitis C virus. Adv Virus Res 78:43-86.
483. Walker, J. M., H. T. Maecker, V. C. Maino, and L. J. Picker. 2004. Multicolor flow cytometric analysis in SIV-infected rhesus macaque. Meth Cell Bio 75:535-557.
484. Walker, L. M., M. D. Simek, F. Priddy, J. S. Gach, D. Wagner, M. B. Zwick, S. K. Phogat, P. Poignard, and D. R. Burton. 2010. A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS pathogens 6:e1001028.
485. Warfield, K. L., D. L. Swenson, G. G. Olinger, W. V. Kalina, M. J. Aman, and S. Bavari. 2007a. Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge. J Infect Dis 196 (Suppl 2):S430-S437.
486. Warfield, K. L., D. L. Swenson, G. G. Olinger, W. V. Kalina, M. Viard, M. Aitichou, X. Chi, S. Ibrahim, R. Blumenthal, Y. Raviv, S. Bavari, and M. J. Aman. 2007b. Ebola virus inactivation with preservation of antigenic and structural integrity by a photoinducible alkylating agent. J Infect Dis 196(Suppl 2):S276-S283.
487. Wedemeyer, H., and S. Pischke. 2011. Hepatitis: Hepatitis E vaccination-is HEV 239 the breakthrough? Nat Rev Gastroenterol Hepatol 8:8-10.
488. Whitehead, S. S., M. G. Hill, C. Y. Firestone, M. St Claire, W. R. Elkins B. R. Murphy, and P. L. Collins. 1999. Replacement of the F and G proteins of respiratory syncytial virus (RSV) subgroup A with those of subgroup B generates chimeric live attenuated RSV subgroup B vaccine candidates. J Virol 73:9773-9780.
489. Willey, R. L., R. Byrum, M. Piatak, Y. B. Kim, M. W. Cho, J. L. Rossio Jr., J. Bess Jr., T. Igarashi, Y. Endo, L. O. Arthur, J. D. Lifson, and M. A. Martin. 2003. Control of viremia and prevention of simian-human immunodeficiency virusinduced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particles. J Virol 77:1163-1174.
490. Wilson, S. J., B. L. Webb, C. Maplanka, R. M. Newman, E. J. Verschoor, J. L. Heeney, and G. J. Towers. 2008. Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities. J Virol 82:7243-7247.
491. Wooding, S., A. C. Stone, D. M. Dunn, S. Mummidi, L. B. Jorde, R. K. Weiss, S. Ahuja, and M. J. Bamshad. 2005. Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5. Am J Hum Genet 76:291-301.
492. Wu, X., Z. Y. Yang, Y. Li, C. M. Hogerkorp, W. R. Schief, M. S. Seaman, T. Zhou, S. D. Schmidt, L. Wu, L. Xu, N. S. Longo, K. McKee, S. O'Dell, M. K. Louder, D. L. Wycuff, Y. Feng, M. Nason, N. Doria-Rose, M. Connors, P. D. Kwong, M. Roederer, R. T. Wyatt, G. J. Nabel, and J. R. Mascola. 2010. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329:856-861.
493. Yant, L. J., T. C. Friedrich, R. C. Johnson, G. E. May, N. J. Maness, A. M. Enz, J. D. Lifson, D. H. O'Connor, M. Carrington, and D. I. Watkins. 2006. The highfrequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication. J Virol 80:5074-5077.
494. Yeh, W. W., P. Jaru-Ampornpan, D. Nevidomskyte, M. Asmal, S. S. Rao, A. P. Buzby, D. C. Montefiori, B. T. Korber, and N. L. Letvin. 2009. Partial protection of Simian immunodeficiency virus (SIV)-infected rhesus monkeys against superinfection with a heterologous SIV isolate. J Virol 83:2686-2696.
495. Yin, J., A. Dai, J. Lecureux, T. Arango, M. A. Kutzler, J. Yan, M. G. Lewis, A. Khan, N. Y. Sardesai, D. Montefiore, R. Ruprecht, D. B. Weiner, and J. D. Boyer. 2010. High antibody and cellular responses induced to HIV-1 clade C envelope following DNA vaccines delivered by electroporation. Vaccine 29:6763-6770.
496. Yu, C., D. Boon, S. L. McDonald, T. G. Myers, K. Tomioka, H. Nguyen, R. E. Engle, S. Govindarajan, S. U. Emerson, and R. H. Purcell. 2010a. Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: Similarities and differences. J Virol 84:11264-11278.
497. Yu, C., D. Boon, S. L. McDonald, T. G. Myers, K. Tomioka, H. Nguyen, R. E. Engle, S. Govindarajan, S. U. Emerson, and R. H. Purcell. 2010b. Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: Similarities and differences. J Virol 84:11264-11278.
498. Zhu, Y. D., J. Heath, J. Collins, T. Greene, L. Antipa, P. Rota, W. Bellini, and M. McChesney. 1997. Experimental measles. II. Infection and immunity in the rhesus macaque. Virology 233:85-92.
499. Zhu, F. C., J. Zhang, X. F. Zhang, C. Zhou, Z. Z. Wang, S. J. Huang, H. Wang, C. L. Yang, H. M. Jiang, J. P. Cai, Y. J. Wang, X. Ai, Y. M. Hu, Q. Tang, X. Yao, Q. Yan, Y. L. Xian, T. Wu, Y. M. Li, J. Miao, M. H. Ng, J. W. Shih, and N. S. Xia. 2010. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: A large-scale, randomised, double-blind placebocontrolled, phase 3 trial. Lancet 376:895-902.
500. Zolla-Pazner, S., X. P. Kong, X. Jiang, T. Cardozo, A. Nadas, S. Cohen, M. Totrov, M. S. Seaman, S. Wang, and S. Lu. 2011. Cross-clade HIV-1 neutralizing antibodies induced with V3-scaffold protein immunogens following priming with gp120 DNA. J Virol.