HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

Science

Volumn 302, Issue 5645, 2003, Pages 659-662

  Grakoui, Arash ^a   Shoukry, Naglaa H ^b   Woollard, David J ^b   Han, Jin Hwan ^a   Hanson, Holly L ^a   Ghrayeb, John ^c   Murthy, Krishna K ^d   Rice, Charles M ^a   Walker, Christopher M ^b,e  

^a ROCKEFELLER UNIVERSITY   (United States)

^b THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c CENTOCOR INC   (United States)

^d SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^e THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELLS; DISEASES; MUTAGENESIS; VIRUSES;

IMMUNE EVASION;

IMMUNOLOGY;

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

HEPATITIS; IMMUNITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIMPANZEE; CONTROLLED STUDY; HEPATITIS C; HEPATITIS C VIRUS; IMMUNE EVASION; IMMUNITY; IMMUNOLOGICAL TOLERANCE; LIVER DISEASE; MEMORY CELL; NONHUMAN; PERSISTENT INFECTION; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; REINFECTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIREMIA; VIRUS ESCAPE MUTATION; VIRUS MUTATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES; EVOLUTION, MOLECULAR; HEPACIVIRUS; HEPATITIS C; IMMUNOLOGIC MEMORY; LIVER; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR SEQUENCE DATA; MUTATION; PAN TROGLODYTES; T-LYMPHOCYTE SUBSETS; TIME FACTORS; VIRAL CORE PROTEINS; VIRAL NONSTRUCTURAL PROTEINS; VIREMIA; VIRUS REPLICATION;

ANIMALIA; HEPATITIS C VIRUS; PAN (APE); PAN TROGLODYTES;

EID: 0142178211     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088774     Document Type: Article

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31. Supported by Public Health service grants to CM.W. (A147367 and AI48231) and C.M.R. (CA57973, CA858B3, and AI40034) and the Greenberg Medical Research Institute. NIH contract N01 HB27091 to K.K.M. is also gratefully acknowledged. A.G. is supported by a Cancer Research Institute Postdoctoral Fellowship award. N.H.S. is the recipient of postdoctoral fellowships from the Canadian Institute for Health Research and the American Liver Foundation. We thank D. Hasselschwert and N. Smith of the New Iberia Research Center, New Iberia, LA, for outstanding veterinary support; D. Conway for superb technical assistance; and J. Stacey for critical reading of the manuscript.