메뉴 건너뛰기




Volumn 239, Issue 1, 2011, Pages 99-108

Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses

Author keywords

HCV immunology; HCV prophylactic vaccine; HCV therapeutic vaccine; Hepatitis C virus; Vaccine

Indexed keywords

ADENOVIRUS VECTOR; ALPHA INTERFERON; GLYCOPROTEIN E1; GLYCOPROTEIN E2; HEPATITIS VACCINE; NEUTRALIZING ANTIBODY; PLASMID DNA; RIBAVIRIN;

EID: 78650536657     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2010.00977.x     Document Type: Article
Times cited : (140)

References (73)
  • 1
    • 61949320778 scopus 로고    scopus 로고
    • Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
    • Gottwein JM, et al. Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology 2009;49:364-377.
    • (2009) Hepatology , vol.49 , pp. 364-377
    • Gottwein, J.M.1
  • 2
    • 0026568641 scopus 로고
    • Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections
    • Weiner AJ, et al. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci USA 1992;89:3468-3472.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3468-3472
    • Weiner, A.J.1
  • 3
    • 77951453698 scopus 로고    scopus 로고
    • Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection
    • Liu L, Fisher BE, Dowd KA, Astemborski J, Cox AL, Ray SC. Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection. J Virol 2010;84:5067-5077.
    • (2010) J Virol , vol.84 , pp. 5067-5077
    • Liu, L.1    Fisher, B.E.2    Dowd, K.A.3    Astemborski, J.4    Cox, A.L.5    Ray, S.C.6
  • 4
    • 77956147218 scopus 로고    scopus 로고
    • Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation
    • Fafi-Kremer S, et al. Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation. J Exp Med 2010;207:2019-2031.
    • (2010) J Exp Med , vol.207 , pp. 2019-2031
    • Fafi-Kremer, S.1
  • 5
    • 66149119738 scopus 로고    scopus 로고
    • Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus
    • Dowd KA, Netski DM, Wang XH, Cox AL, Ray SC. Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus. Gastroenterology 2009;136:2377-2386.
    • (2009) Gastroenterology , vol.136 , pp. 2377-2386
    • Dowd, K.A.1    Netski, D.M.2    Wang, X.H.3    Cox, A.L.4    Ray, S.C.5
  • 6
    • 75449101959 scopus 로고    scopus 로고
    • Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
    • Fuller MJ, et al. Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology 2010;51:378-387.
    • (2010) Hepatology , vol.51 , pp. 378-387
    • Fuller, M.J.1
  • 7
    • 70349245146 scopus 로고    scopus 로고
    • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus
    • Horner SM, Gale M Jr. Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. J Interferon Cytokine Res 2009;29:489-498.
    • (2009) J Interferon Cytokine Res , vol.29 , pp. 489-498
    • Horner, S.M.1    Gale Jr, M.2
  • 8
    • 0037033359 scopus 로고    scopus 로고
    • Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein
    • Crotta S, et al. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med 2002;195:35-41.
    • (2002) J Exp Med , vol.195 , pp. 35-41
    • Crotta, S.1
  • 9
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
    • Tseng CT, Klimpel GR. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med 2002;195:43-49.
    • (2002) J Exp Med , vol.195 , pp. 43-49
    • Tseng, C.T.1    Klimpel, G.R.2
  • 10
    • 34547098102 scopus 로고    scopus 로고
    • The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein
    • Helle F, et al. The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein. J Virol 2007;81:8101-8111.
    • (2007) J Virol , vol.81 , pp. 8101-8111
    • Helle, F.1
  • 11
    • 35348898348 scopus 로고    scopus 로고
    • Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies
    • Stamataki Z, et al. Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies. Vaccine 2007;25:7773-7784.
    • (2007) Vaccine , vol.25 , pp. 7773-7784
    • Stamataki, Z.1
  • 12
    • 20744437263 scopus 로고    scopus 로고
    • An interplay between hypervariable region 1 of the hepatitis C virus E2 glycoprotein, the scavenger receptor BI, and high-density lipoprotein promotes both enhancement of infection and protection against neutralizing antibodies
    • Bartosch B, et al. An interplay between hypervariable region 1 of the hepatitis C virus E2 glycoprotein, the scavenger receptor BI, and high-density lipoprotein promotes both enhancement of infection and protection against neutralizing antibodies. J Virol 2005;79:8217-8229.
    • (2005) J Virol , vol.79 , pp. 8217-8229
    • Bartosch, B.1
  • 13
    • 38649100951 scopus 로고    scopus 로고
    • Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies
    • Timpe JM, et al. Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies. Hepatology 2008;47:17-24.
    • (2008) Hepatology , vol.47 , pp. 17-24
    • Timpe, J.M.1
  • 14
    • 66149135701 scopus 로고    scopus 로고
    • Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    • Zhang P, et al. Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity. Proc Natl Acad Sci USA 2009;106:7537-7541.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7537-7541
    • Zhang, P.1
  • 15
    • 29444444292 scopus 로고    scopus 로고
    • Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
    • Rosa D, et al. Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders. Proc Natl Acad Sci USA 2005; 102:18544-18549.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18544-18549
    • Rosa, D.1
  • 16
    • 47949111314 scopus 로고    scopus 로고
    • Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function
    • Serra A, et al. Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function. J Immunol 2008;181:174-185.
    • (2008) J Immunol , vol.181 , pp. 174-185
    • Serra, A.1
  • 17
    • 70350493684 scopus 로고    scopus 로고
    • The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo
    • Kriegs M, et al. The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo. J Biol Chem 2009; 284:28343-28351.
    • (2009) J Biol Chem , vol.284 , pp. 28343-28351
    • Kriegs, M.1
  • 18
    • 7244232705 scopus 로고    scopus 로고
    • Association of hepatitis C virus envelope proteins with exosomes
    • Masciopinto F, et al. Association of hepatitis C virus envelope proteins with exosomes. Eur J Immunol 2004;34:2834-2842.
    • (2004) Eur J Immunol , vol.34 , pp. 2834-2842
    • Masciopinto, F.1
  • 19
    • 24344503816 scopus 로고    scopus 로고
    • HCV natural history: the retrospective and prospective in perspective., J Hepatol
    • Alter HJ. HCV natural history: the retrospective and prospective in perspective. J Hepatol 2005;43:550-552.
    • (2005) , vol.43 , pp. 550-552
    • Alter, H.J.1
  • 20
    • 34848860016 scopus 로고    scopus 로고
    • Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection
    • Lucas M, et al. Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection. PLoS ONE 2007;2:e649.
    • (2007) PLoS ONE , vol.2
    • Lucas, M.1
  • 21
    • 0034959575 scopus 로고    scopus 로고
    • Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity
    • Weiner AJ, et al. Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity. J Virol 2001;75:7142-7148.
    • (2001) J Virol , vol.75 , pp. 7142-7148
    • Weiner, A.J.1
  • 22
    • 0347634389 scopus 로고    scopus 로고
    • Cross-genotype immunity to hepatitis C virus
    • Lanford RE, et al. Cross-genotype immunity to hepatitis C virus. J Virol 2004;78:1575-1581.
    • (2004) J Virol , vol.78 , pp. 1575-1581
    • Lanford, R.E.1
  • 23
    • 72249087933 scopus 로고    scopus 로고
    • Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection
    • Osburn WO, et al. Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection. Gastroenterology 2010;138:315-324.
    • (2010) Gastroenterology , vol.138 , pp. 315-324
    • Osburn, W.O.1
  • 24
    • 49149114141 scopus 로고    scopus 로고
    • Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain
    • Bukh J, et al. Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain. J Virol 2008;82:8183-8195.
    • (2008) J Virol , vol.82 , pp. 8183-8195
    • Bukh, J.1
  • 25
    • 27744438976 scopus 로고    scopus 로고
    • Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model
    • Prince AM, et al. Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model. J Infect Dis 2005;192:1701-1709.
    • (2005) J Infect Dis , vol.192 , pp. 1701-1709
    • Prince, A.M.1
  • 26
    • 0037181727 scopus 로고    scopus 로고
    • Protection against persistence of hepatitis C
    • Mehta SH, et al. Protection against persistence of hepatitis C. Lancet 2002;359:1478-1483.
    • (2002) Lancet , vol.359 , pp. 1478-1483
    • Mehta, S.H.1
  • 27
    • 34250679750 scopus 로고    scopus 로고
    • Epidemiology of hepatitis C virus infection
    • Alter MJ. Epidemiology of hepatitis C virus infection. World J Gastroenterol 2007;13:2436-2441.
    • (2007) World J Gastroenterol , vol.13 , pp. 2436-2441
    • Alter, M.J.1
  • 28
    • 53549115066 scopus 로고    scopus 로고
    • Natural history of hepatitis C virus infection in HIV-infected individuals and the impact of HIV in the era of highly active antiretroviral therapy: a meta-analysis
    • Thein HH, Yi Q, Dore GJ, Krahn MD. Natural history of hepatitis C virus infection in HIV-infected individuals and the impact of HIV in the era of highly active antiretroviral therapy: a meta-analysis. AIDS 2008;22:1979-1991.
    • (2008) AIDS , vol.22 , pp. 1979-1991
    • Thein, H.H.1    Yi, Q.2    Dore, G.J.3    Krahn, M.D.4
  • 29
    • 0033458949 scopus 로고    scopus 로고
    • Mother-to-infant transmission of hepatitis C virus
    • Zanetti AR, Tanzi E, Newell ML. Mother-to-infant transmission of hepatitis C virus. J Hepatol 1999;31(Suppl.):96-100.
    • (1999) J Hepatol , vol.31 , Issue.SUPPL. , pp. 96-100
    • Zanetti, A.R.1    Tanzi, E.2    Newell, M.L.3
  • 30
    • 0026724046 scopus 로고
    • Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells
    • Spaete RR, et al. Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells. Virology 1992; 188:819-830.
    • (1992) Virology , vol.188 , pp. 819-830
    • Spaete, R.R.1
  • 31
    • 0027442136 scopus 로고
    • Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses
    • Ralston R, et al. Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol 1993;67:6753-6761.
    • (1993) J Virol , vol.67 , pp. 6753-6761
    • Ralston, R.1
  • 32
    • 77956832815 scopus 로고    scopus 로고
    • Characterization of the envelope glycoproteins associated with infectious hepatitis C virus
    • Vieyres G, Thomas X, Descamps V, Duverlie G, Patel AH, Dubuisson J. Characterization of the envelope glycoproteins associated with infectious hepatitis C virus. J Virol 2010;84:10159-10168.
    • (2010) J Virol , vol.84 , pp. 10159-10168
    • Vieyres, G.1    Thomas, X.2    Descamps, V.3    Duverlie, G.4    Patel, A.H.5    Dubuisson, J.6
  • 33
    • 0027454386 scopus 로고
    • Persistence of HCV despite antibodies to both putative envelope glycoproteins
    • Chien DY, et al. Persistence of HCV despite antibodies to both putative envelope glycoproteins. Lancet 1993;342:933.
    • (1993) Lancet , vol.342 , pp. 933
    • Chien, D.Y.1
  • 34
    • 0028147612 scopus 로고
    • Vaccination of chimpanzees against infection by the hepatitis C virus
    • Choo QL, et al. Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci USA 1994;91:1294-1298.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1294-1298
    • Choo, Q.L.1
  • 35
    • 0002748743 scopus 로고    scopus 로고
    • Viral Hepatitis and Liver Disease
    • In: Rizzetto M, Purcell RH, Gerin JL, Verme G, eds. Turin: Edizioni Minerva Medica.
    • Houghton M, et al. Development of a HCV Vaccine. In: Rizzetto M, Purcell RH, Gerin JL, Verme G eds. Viral Hepatitis and Liver Disease. Turin: Edizioni Minerva Medica, 1997:656-659.
    • (1997) Development of a HCV Vaccine , pp. 656-659
    • Houghton, M.1
  • 36
    • 78650569647 scopus 로고    scopus 로고
    • Proceedings of the 11th International Symposium on Viral Hepatitis and Liver Disease
    • In: Jilbert AR, Grgacic EVL, Vickery K, Burrell CJ, Cossart YE, eds. Sydney: Australian Center for Hepatitis Virology.
    • Coates S, et al. Protection of chimpanzees against heterologous 1a viral challenge using a gpE1/gpE2 heterodimer vaccine. In: Jilbert AR, Grgacic EVL, Vickery K, Burrell CJ, Cossart YE eds. Proceedings of the 11th International Symposium on Viral Hepatitis and Liver Disease. Sydney: Australian Center for Hepatitis Virology, 2005:118-123.
    • (2005) Protection of chimpanzees against heterologous 1a viral challenge using a gpE1/gpE2 heterodimer vaccine , pp. 118-123
    • Coates, S.1
  • 37
    • 23944452579 scopus 로고    scopus 로고
    • Prospects for a vaccine against the hepatitis C virus
    • Houghton M, Abrignani S. Prospects for a vaccine against the hepatitis C virus. Nature 2005;436:961-966.
    • (2005) Nature , vol.436 , pp. 961-966
    • Houghton, M.1    Abrignani, S.2
  • 38
    • 0037301154 scopus 로고    scopus 로고
    • Hepatitis C virus genetic variability: pathogenic and clinical implications
    • Pawlotsky JM. Hepatitis C virus genetic variability: pathogenic and clinical implications. Clin Liver Dis 2003;7:45-66.
    • (2003) Clin Liver Dis , vol.7 , pp. 45-66
    • Pawlotsky, J.M.1
  • 39
    • 0034885745 scopus 로고    scopus 로고
    • Studies of hepatitis C virus in chimpanzees and their importance for vaccine development
    • Bukh J, Forns X, Emerson SU, Purcell RH. Studies of hepatitis C virus in chimpanzees and their importance for vaccine development. Intervirology 2001;44:132-142.
    • (2001) Intervirology , vol.44 , pp. 132-142
    • Bukh, J.1    Forns, X.2    Emerson, S.U.3    Purcell, R.H.4
  • 40
    • 77955283850 scopus 로고    scopus 로고
    • Patient HLA-DRB1* and -DQB1* allele and haplotype association with hepatitis C virus persistence and clearance
    • Ali L, et al. Patient HLA-DRB1* and -DQB1* allele and haplotype association with hepatitis C virus persistence and clearance. J Gen Virol 2010;91:1931-1938.
    • (2010) J Gen Virol , vol.91 , pp. 1931-1938
    • Ali, L.1
  • 41
    • 77950607813 scopus 로고    scopus 로고
    • Natural killer cell receptor and HLA-C gene polymorphisms among patients with hepatitis C: a comparison between sustained virological responders and non-responders
    • Carneiro VL, et al. Natural killer cell receptor and HLA-C gene polymorphisms among patients with hepatitis C: a comparison between sustained virological responders and non-responders. Liver Int 2010;30:567-573.
    • (2010) Liver Int , vol.30 , pp. 567-573
    • Carneiro, V.L.1
  • 42
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009;461:798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1
  • 43
    • 38049083122 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
    • Law M, et al. Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med 2008;14:25-27.
    • (2008) Nat Med , vol.14 , pp. 25-27
    • Law, M.1
  • 44
    • 20944449916 scopus 로고    scopus 로고
    • Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection
    • Lavillette D, et al. Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection. J Virol 2005;79:6023-6034.
    • (2005) J Virol , vol.79 , pp. 6023-6034
    • Lavillette, D.1
  • 45
    • 34347230939 scopus 로고    scopus 로고
    • Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    • Pestka JM, et al. Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci USA 2007;104:6025-6030.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6025-6030
    • Pestka, J.M.1
  • 46
    • 3042841149 scopus 로고    scopus 로고
    • Neutralizing antibody response during acute and chronic hepatitis C virus infection
    • Logvinoff C, et al. Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proc Natl Acad Sci USA 2004;101:10149-10154.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10149-10154
    • Logvinoff, C.1
  • 47
    • 77955661037 scopus 로고    scopus 로고
    • Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults
    • Frey SE, et al. Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. Vaccine 2010;28:6367-6373.
    • (2010) Vaccine , vol.28 , pp. 6367-6373
    • Frey, S.E.1
  • 48
    • 77955659499 scopus 로고    scopus 로고
    • Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins
    • Ray R, et al. Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins. J Infect Dis 2010;202:862-866.
    • (2010) J Infect Dis , vol.202 , pp. 862-866
    • Ray, R.1
  • 49
    • 22144434860 scopus 로고    scopus 로고
    • Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoing chronic HCV infection
    • Leroux-Roels G, et al. Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoing chronic HCV infection. Hum Vaccin 2005;1:61-65.
    • (2005) Hum Vaccin , vol.1 , pp. 61-65
    • Leroux-Roels, G.1
  • 50
    • 2942643931 scopus 로고    scopus 로고
    • Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity
    • Keck ZY, et al. Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity. J Virol 2004;78:7257-7263.
    • (2004) J Virol , vol.78 , pp. 7257-7263
    • Keck, Z.Y.1
  • 52
    • 0142178211 scopus 로고    scopus 로고
    • HCV persistence and immune evasion in the absence of memory T cell help
    • Grakoui A, et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 2003;302:659-662.
    • (2003) Science , vol.302 , pp. 659-662
    • Grakoui, A.1
  • 53
    • 0038543543 scopus 로고    scopus 로고
    • Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection
    • Shoukry NH, et al. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 2003;197:1645-1655.
    • (2003) J Exp Med , vol.197 , pp. 1645-1655
    • Shoukry, N.H.1
  • 54
    • 0033119925 scopus 로고    scopus 로고
    • Analysis of a successful immune response against hepatitis C virus
    • Cooper S, et al. Analysis of a successful immune response against hepatitis C virus. Immunity 1999;10:439-449.
    • (1999) Immunity , vol.10 , pp. 439-449
    • Cooper, S.1
  • 55
    • 33947409611 scopus 로고    scopus 로고
    • Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity
    • Rollier CS, et al. Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity. Hepatology 2007;45:602-613.
    • (2007) Hepatology , vol.45 , pp. 602-613
    • Rollier, C.S.1
  • 56
    • 32244435842 scopus 로고    scopus 로고
    • A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
    • Folgori A, et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat Med 2006;12:190-197.
    • (2006) Nat Med , vol.12 , pp. 190-197
    • Folgori, A.1
  • 57
    • 55249088800 scopus 로고    scopus 로고
    • Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus
    • Youn JW, et al. Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus. J Virol 2008;82:10896-10905.
    • (2008) J Virol , vol.82 , pp. 10896-10905
    • Youn, J.W.1
  • 58
    • 77956119219 scopus 로고    scopus 로고
    • Induction of broadly neutralizing H1N1 influenza antibodies by vaccination
    • Wei CJ, et al. Induction of broadly neutralizing H1N1 influenza antibodies by vaccination. Science 2010;329:1060-1064.
    • (2010) Science , vol.329 , pp. 1060-1064
    • Wei, C.J.1
  • 59
    • 47749130475 scopus 로고    scopus 로고
    • Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5
    • Lin Y, et al. Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. J Virol 2008;82:7492-7503.
    • (2008) J Virol , vol.82 , pp. 7492-7503
    • Lin, Y.1
  • 60
    • 34249885360 scopus 로고    scopus 로고
    • Chronic infections with hepatotropic viruses: mechanisms of impairment of cellular immune responses
    • Rehermann B. Chronic infections with hepatotropic viruses: mechanisms of impairment of cellular immune responses. Semin Liver Dis 2007;27:152-160.
    • (2007) Semin Liver Dis , vol.27 , pp. 152-160
    • Rehermann, B.1
  • 61
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001;194:1395-1406.
    • (2001) J Exp Med , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 62
    • 60849094472 scopus 로고    scopus 로고
    • Vaccination against hepatitis B and C: towards therapeutic application
    • Inchauspe G, Bach G, Martin P, Bonnefoy JY. Vaccination against hepatitis B and C: towards therapeutic application. Int Rev Immunol 2009;28:7-19.
    • (2009) Int Rev Immunol , vol.28 , pp. 7-19
    • Inchauspe, G.1    Bach, G.2    Martin, P.3    Bonnefoy, J.Y.4
  • 63
    • 78650579784 scopus 로고    scopus 로고
    • Transgene.
    • Transgene.
  • 64
    • 78650582430 scopus 로고    scopus 로고
    • Okairos.
    • Okairos.
  • 65
    • 0035284757 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine
    • Polakos NK, et al. Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine. J Immunol 2001;166:3589-3598.
    • (2001) J Immunol , vol.166 , pp. 3589-3598
    • Polakos, N.K.1
  • 66
    • 67549123833 scopus 로고    scopus 로고
    • Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers
    • Drane D, et al. Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers. Hum Vaccin 2009;5:151-157.
    • (2009) Hum Vaccin , vol.5 , pp. 151-157
    • Drane, D.1
  • 67
    • 43849104724 scopus 로고    scopus 로고
    • In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ T cells
    • Ahlén G, et al. In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ T cells. J Immunol 2007;179:4741-4753.
    • (2007) J Immunol , vol.179 , pp. 4741-4753
    • Ahlén, G.1
  • 68
    • 78650542755 scopus 로고    scopus 로고
    • Abstract at Hepdart 2009 meeting on Viral Hepatitis.
    • Sallberg M. Abstract at Hepdart 2009 meeting on Viral Hepatitis.
    • Sallberg, M.1
  • 69
    • 78650552694 scopus 로고    scopus 로고
    • Intercell.
    • Intercell.
  • 70
    • 0037105567 scopus 로고    scopus 로고
    • Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    • Wedemeyer H, et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 2002;169:3447-3458.
    • (2002) J Immunol , vol.169 , pp. 3447-3458
    • Wedemeyer, H.1
  • 71
    • 77957059176 scopus 로고    scopus 로고
    • Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
    • Jin HT, et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA 2010;107:14733-14738.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14733-14738
    • Jin, H.T.1
  • 72
    • 19944370822 scopus 로고    scopus 로고
    • T cells with a CD4+ CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection
    • Boettler T, et al. T cells with a CD4+ CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005;79:7860-7867.
    • (2005) J Virol , vol.79 , pp. 7860-7867
    • Boettler, T.1
  • 73
    • 23944467250 scopus 로고    scopus 로고
    • Adaptive immune responses in acute and chronic hepatitis C virus infection
    • Bowen DG, Walker CM. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 2005;436:946-952.
    • (2005) Nature , vol.436 , pp. 946-952
    • Bowen, D.G.1    Walker, C.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.