The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes

Immunity

Volumn 15, Issue 6, 2001, Pages 883-895

  Erickson, Ann L ^a   Kimura, Yoichi ^a   Igarashi, Suzu ^a   Eichelberger, Jennifer ^a   Houghton, Michael ^b   Sidney, John ^c   McKinney, Denise ^c   Sette, Alessandro ^c   Hughes, Austin L ^d   Walker, Christopher M ^a,e  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Epimmune   (United States)

^d UNIVERSITY OF SOUTH CAROLINA   (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; CHIMPANZEE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HEPATITIS C; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENTIATION; VIRUS INFECTION; VIRUS MUTATION; VIRUS REPLICATION;

EID: 18244397979     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00245-X     Document Type: Article

References (35)

1. Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus
2. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules
3. Genetic heterogeneity of hepatitis C virus: Quasispecies and genotypes
4. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif
5. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
6. Identification of the major, parenteral non-A, non-B hepatitis agent (hepatitis C virus) using a recombinant cDNA approach
7. Analysis of a successful immune response against hepatitis C virus
8. Immunobiology of hepatitis C virus (HCV) infection: The role of CD4 T cells in HCV infection
9. Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C
10. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env. and Nef
11. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
12. Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection
13. + T cells with viral clearance in acute hepatitis C
14. +) t lymphocytes after infection with hepatitis c virus
15. +) T cells in peripheral blood and liver using peptide-MHC tetramers
16. Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection
17. Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope
18. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes
19. + cytotoxic T cells from two chronically infected chimpanzees
20. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis
21. + T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained
22. Analysis of successful immune responses in persons infected with hepatitis C virus
23. Dominant role of host selective pressure in driving hepatitis C virus evolution in perinatal infection
24. T cell responses and viral escape
25. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions
26. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
27. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
28. An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans
29. +) T-cell expansion in patients with acute hepatitis C
30. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
31. Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
32. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant
33. Liver-derived CTL in hepatitis C virus infection: Breadth and specificity of responses in a cohort of persons with chronic infection
34. Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV