Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 27, 2011, Pages 11223-11228

  Lanford, Robert E ^a,b   Feng, Zongdi ^c   Chavez, Deborah ^a   Guerra, Bernadette ^a   Brasky, Kathleen M ^b   Zhou, Yan ^d   Yamane, Daisuke ^c   Perelson, Alan S ^e   Walker, Christopher M ^d   Lemon, Stanley M ^c  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d NATIONWIDE CHILDREN S HOSPITAL   (United States)

^e LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

Immune evasion; Innate immunity; Viral persistence

Indexed keywords

INTERFERON; VIRUS RNA;

ACUTE HEPATITIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHIMPANZEE; COMPARATIVE STUDY; GENE EXPRESSION; HEPATITIS A; HEPATITIS A VIRUS; HEPATITIS C; INNATE IMMUNITY; LIVER LEVEL; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; VIREMIA; VIRUS CELL INTERACTION;

ACUTE DISEASE; ANIMALS; BASE SEQUENCE; DNA PRIMERS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEPACIVIRUS; HEPATITIS A; HEPATITIS A VIRUS; HEPATITIS C; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INTERFERON TYPE I; LIVER; PAN TROGLODYTES; RNA, VIRAL; TIME FACTORS;

ANIMALIA; FLAVIVIRUS; HEPATITIS A VIRUS; HEPATITIS C VIRUS; PAN; PICORNAVIRIDAE;

EID: 79960581035     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101939108     Document Type: Article

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