A chimeric HIV-1 envelope glycoprotein trimer with an embedded Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) domain induces enhanced antibody and T cell responses

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22250-22261

  Van Montfort, Thijs ^a   Melchers, Mark ^a   Isik, Gözde ^a   Menis, Sergey ^b   Huang, Po Ssu ^b   Matthews, Katie ^c   Michael, Elizabeth ^c   Berkhout, Ben ^a   Schief, William R ^b   Moore, John P ^c   Sanders, Rogier W ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF WASHINGTON   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RESPONSE; CHIMERIC PROTEINS; CYTOKINES; ENVELOPE GLYCOPROTEINS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTORS; IMMUNE CELLS; IMMUNE RESPONSE; IMMUNOGENICITY; IN-VITRO; NEUTRALIZING ANTIBODIES; PROTEIN DOMAINS; SUBUNIT VACCINE; T-CELL RESPONSE; WILD TYPES;

GLYCOPROTEINS; MACROPHAGES; MAMMALS; OLIGOMERS; VACCINES;

ANTIBODIES;

GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 140; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOKINE RELEASE; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; T LYMPHOCYTE; VIRUS NEUTRALIZATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEK293 CELLS; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; VIRAL VACCINES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79959360925     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.229625     Document Type: Article

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