Fully human monoclonal antibody directed to proteolytic cleavage site in Severe Acute Respiratory Syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model

Journal of Infectious Diseases

Volumn 203, Issue 11, 2011, Pages 1574-1581

  Miyoshi Akiyama, Tohru ^a   Ishida, Isao ^b   Fukushi, Masaya ^a   Yamaguchi, Keina ^b   Matsuoka, Yusuke ^a   Ishihara, Takashi ^b   Tsukahara, Masayoshi ^b   Hatakeyama, Seisuke ^a   Itoh, Norikazu ^a   Morisawa, Aki ^a   Yoshinaka, Yoshiyuki ^c   Yamamoto, Naoki ^d   Lianfeng, Zhang ^e   Chuan, Qin ^e   Kirikae, Teruo ^a   Sasazuki, Takehiko ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^e INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5H10; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN RECOGNITION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; HOST CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS NEUTRALIZATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; BLOTTING, WESTERN; CATALYTIC DOMAIN; CELL FUSION; DISEASE MODELS, ANIMAL; GIANT CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; MACACA MULATTA; MEMBRANE GLYCOPROTEINS; MICE; PEPTIDYL-DIPEPTIDASE A; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL ENVELOPE PROTEINS;

EID: 79956227227     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir084     Document Type: Article

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