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Volumn 33, Issue 5, 2011, Pages 501-513

Review article: Chronic hepatitis B - Anti-viral or immunomodulatory therapy?

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; ALANINE AMINOTRANSFERASE; ENTECAVIR; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; NUCLEOTIDE DERIVATIVE; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PLACEBO; RIBAVIRIN; TELBIVUDINE; TENOFOVIR; TENOFOVIR DISOPROXIL; VIRUS DNA;

EID: 79251496109     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2010.04555.x     Document Type: Review
Times cited : (39)

References (100)
  • 1
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Liaw YF, Chu CM,. Hepatitis B virus infection. Lancet 2009; 373: 582-92.
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 2
    • 58149296156 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: Management of chronic hepatitis B
    • European Association for the Study of the Liver.
    • European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of chronic hepatitis B. J Hepatol 2009; 50: 227-42.
    • (2009) J Hepatol , vol.50 , pp. 227-242
  • 3
    • 51049107683 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2008 update
    • Liaw YF, Leung N, Kao JH, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int 2008; 2: 263-83.
    • (2008) Hepatol Int , vol.2 , pp. 263-283
    • Liaw, Y.F.1    Leung, N.2    Kao, J.H.3
  • 4
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: Update 2009
    • Lok AS, McMahon BJ,. Chronic hepatitis B: update 2009. Hepatology 2009; 50: 661-2.
    • (2009) Hepatology , vol.50 , pp. 661-662
    • Lok, A.S.1    McMahon, B.J.2
  • 5
    • 30344448558 scopus 로고    scopus 로고
    • Treatment of hepatitis B: Who, when, and how?
    • Wong SN, Lok AS,. Treatment of hepatitis B: who, when, and how? Arch Intern Med 2006; 166: 9-12.
    • (2006) Arch Intern Med , vol.166 , pp. 9-12
    • Wong, S.N.1    Lok, A.S.2
  • 6
    • 0034802538 scopus 로고    scopus 로고
    • Hepatitis B e antigen-negative chronic hepatitis B
    • Hadziyannis SJ, Vassilopoulos D,. Hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2001; 34: 617-24.
    • (2001) Hepatology , vol.34 , pp. 617-624
    • Hadziyannis, S.J.1    Vassilopoulos, D.2
  • 7
    • 58749111990 scopus 로고    scopus 로고
    • National Institutes of Health Consensus Development Conference Statement: Management of hepatitis B
    • Sorrell MF, Belongia EA, Costa J, et al. National Institutes of Health Consensus Development Conference Statement: management of hepatitis B. Ann Intern Med 2009; 150: 104-10.
    • (2009) Ann Intern Med , vol.150 , pp. 104-110
    • Sorrell, M.F.1    Belongia, E.A.2    Costa, J.3
  • 8
    • 2942534508 scopus 로고    scopus 로고
    • Molecular virology of hepatitis B virus
    • Locarnini S,. Molecular virology of hepatitis B virus. Semin Liver Dis 2004; 24 (Suppl. 1): 3-10.
    • (2004) Semin Liver Dis , vol.24 , Issue.SUPPL. 1 , pp. 3-10
    • Locarnini, S.1
  • 9
    • 66149168936 scopus 로고    scopus 로고
    • Endpoints of therapy in chronic hepatitis B
    • Feld JJ, Wong DK, Heathcote EJ,. Endpoints of therapy in chronic hepatitis B. Hepatology 2009; 5 (Suppl.): S96-102.
    • (2009) Hepatology , vol.5 , Issue.SUPPL.
    • Feld, J.J.1    Wong, D.K.2    Heathcote, E.J.3
  • 10
    • 66149164719 scopus 로고    scopus 로고
    • Antiviral resistance and hepatitis B therapy
    • Ghany MG, Doo EC,. Antiviral resistance and hepatitis B therapy. Hepatology 2009; 5 (Suppl.): S174-84.
    • (2009) Hepatology , vol.5 , Issue.SUPPL.
    • Ghany, M.G.1    Doo, E.C.2
  • 11
    • 0029925880 scopus 로고    scopus 로고
    • Actions of cytokines on the immune response and viral interactions: An overview
    • Peters M,. Actions of cytokines on the immune response and viral interactions: an overview. Hepatology 1996; 23: 909-16.
    • (1996) Hepatology , vol.23 , pp. 909-916
    • Peters, M.1
  • 12
    • 70350095437 scopus 로고    scopus 로고
    • Hepatitis B virus resistance to nucleos(t)ide analogues
    • Zoulim F, Locarnini S,. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology 2009; 137: 1593-608.
    • (2009) Gastroenterology , vol.137 , pp. 1593-1608
    • Zoulim, F.1    Locarnini, S.2
  • 13
    • 38349108753 scopus 로고    scopus 로고
    • Long-term outcome of chronic hepatitis B in Caucasian patients: Mortality after 25 years
    • Fattovich G, Olivari N, Pasino M, D'Onofrio M, Martone E, Donato F,. Long-term outcome of chronic hepatitis B in Caucasian patients: mortality after 25 years. Gut 2008; 57: 84-90.
    • (2008) Gut , vol.57 , pp. 84-90
    • Fattovich, G.1    Olivari, N.2    Pasino, M.3    D'Onofrio, M.4    Martone, E.5    Donato, F.6
  • 14
    • 0029893146 scopus 로고    scopus 로고
    • Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B
    • Niederau C, Heintges T, Lange S, et al. Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. N Engl J Med 1996; 334: 1422-7.
    • (1996) N Engl J Med , vol.334 , pp. 1422-1427
    • Niederau, C.1    Heintges, T.2    Lange, S.3
  • 15
    • 1542724805 scopus 로고    scopus 로고
    • Long-term follow-up of alpha-interferon treatment of patients with chronic hepatitis B
    • van Zonneveld M, Honkoop P, Hansen BE, et al. Long-term follow-up of alpha-interferon treatment of patients with chronic hepatitis B. Hepatology 2004; 39: 804-10.
    • (2004) Hepatology , vol.39 , pp. 804-810
    • Van Zonneveld, M.1    Honkoop, P.2    Hansen, B.E.3
  • 16
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    • Chen CJ, Yang HI, Su J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65-73.
    • (2006) JAMA , vol.295 , pp. 65-73
    • Chen, C.J.1    Yang, H.I.2    Su, J.3
  • 17
    • 33644858331 scopus 로고    scopus 로고
    • Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    • Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ,. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678-86.
    • (2006) Gastroenterology , vol.130 , pp. 678-686
    • Iloeje, U.H.1    Yang, H.I.2    Su, J.3    Jen, C.L.4    You, S.L.5    Chen, C.J.6
  • 18
    • 38049044476 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
    • Fattovich G, Bortolotti F, Donato F,. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 2008; 48: 335-52.
    • (2008) J Hepatol , vol.48 , pp. 335-352
    • Fattovich, G.1    Bortolotti, F.2    Donato, F.3
  • 19
    • 33644818518 scopus 로고    scopus 로고
    • A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    • Chang TT, Gish RG, de Man R, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 2006; 354: 1001-10.
    • (2006) N Engl J Med , vol.354 , pp. 1001-1010
    • Chang, T.T.1    Gish, R.G.2    De Man, R.3
  • 20
    • 0034235528 scopus 로고    scopus 로고
    • Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group
    • Liaw YF, Leung NW, Chang TT, et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. Gastroenterology 2000; 119: 172-80.
    • (2000) Gastroenterology , vol.119 , pp. 172-180
    • Liaw, Y.F.1    Leung, N.W.2    Chang, T.T.3
  • 21
    • 8344277996 scopus 로고    scopus 로고
    • Four years of lamivudine treatment in Chinese patients with chronic hepatitis B
    • Chang TT, Lai CL, Chien RN, et al. Four years of lamivudine treatment in Chinese patients with chronic hepatitis B. J Gastroenterol Hepatol 2004; 19: 1276-82.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 1276-1282
    • Chang, T.T.1    Lai, C.L.2    Chien, R.N.3
  • 22
    • 0034993211 scopus 로고    scopus 로고
    • Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy
    • Leung NW, Lai CL, Chang TT, et al. Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy. Hepatology 2001; 33: 1527-32.
    • (2001) Hepatology , vol.33 , pp. 1527-1532
    • Leung, N.W.1    Lai, C.L.2    Chang, T.T.3
  • 23
    • 33644822860 scopus 로고    scopus 로고
    • Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    • Lai CL, Shouval D, Lok AS, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2006; 354: 1011-20.
    • (2006) N Engl J Med , vol.354 , pp. 1011-1020
    • Lai, C.L.1    Shouval, D.2    Lok, A.S.3
  • 24
    • 21344460718 scopus 로고    scopus 로고
    • Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine
    • Papatheodoridis GV, Dimou E, Dimakopoulos K, et al. Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine. Hepatology 2005; 42: 121-9.
    • (2005) Hepatology , vol.42 , pp. 121-129
    • Papatheodoridis, G.V.1    Dimou, E.2    Dimakopoulos, K.3
  • 25
    • 0037221907 scopus 로고    scopus 로고
    • Histological outcome during long-term lamivudine therapy
    • Dienstag JL, Goldin RD, Heathcote EJ, et al. Histological outcome during long-term lamivudine therapy. Gastroenterology 2003; 124: 105-17.
    • (2003) Gastroenterology , vol.124 , pp. 105-117
    • Dienstag, J.L.1    Goldin, R.D.2    Heathcote, E.J.3
  • 26
    • 19544391413 scopus 로고    scopus 로고
    • Lamivudine for patients with chronic hepatitis B and advanced liver disease
    • Liaw YF, Sung JJ, Chow WC, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 2004; 351: 1521-31.
    • (2004) N Engl J Med , vol.351 , pp. 1521-1531
    • Liaw, Y.F.1    Sung, J.J.2    Chow, W.C.3
  • 27
    • 10744225554 scopus 로고    scopus 로고
    • Long-term safety of lamivudine treatment in patients with chronic hepatitis B
    • Lok AS, Lai CL, Leung N, et al. Long-term safety of lamivudine treatment in patients with chronic hepatitis B. Gastroenterology 2003; 125: 1714-22.
    • (2003) Gastroenterology , vol.125 , pp. 1714-1722
    • Lok, A.S.1    Lai, C.L.2    Leung, N.3
  • 28
    • 0037468421 scopus 로고    scopus 로고
    • Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • Marcellin P, Chang TT, Lim SG, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med 2003; 348: 808-16.
    • (2003) N Engl J Med , vol.348 , pp. 808-816
    • Marcellin, P.1    Chang, T.T.2    Lim, S.G.3
  • 29
    • 51349107091 scopus 로고    scopus 로고
    • Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • Marcellin P, Chang TT, Lim SG, et al. Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. Hepatology 2008; 48: 750-8.
    • (2008) Hepatology , vol.48 , pp. 750-758
    • Marcellin, P.1    Chang, T.T.2    Lim, S.G.3
  • 30
    • 0037468406 scopus 로고    scopus 로고
    • Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B
    • Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B. N Engl J Med 2003; 348: 800-7.
    • (2003) N Engl J Med , vol.348 , pp. 800-807
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3
  • 31
    • 21244455293 scopus 로고    scopus 로고
    • Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B
    • Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N Engl J Med 2005; 352: 2673-81.
    • (2005) N Engl J Med , vol.352 , pp. 2673-2681
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3
  • 32
    • 33845671388 scopus 로고    scopus 로고
    • Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years
    • Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years. Gastroenterology 2006; 131: 1743-51.
    • (2006) Gastroenterology , vol.131 , pp. 1743-1751
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3
  • 33
    • 37349120537 scopus 로고    scopus 로고
    • Telbivudine versus lamivudine in patients with chronic hepatitis B
    • Lai CL, Gane E, Liaw YF, et al. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med 2007; 357: 2576-88.
    • (2007) N Engl J Med , vol.357 , pp. 2576-2588
    • Lai, C.L.1    Gane, E.2    Liaw, Y.F.3
  • 34
    • 58649096155 scopus 로고    scopus 로고
    • 2-Year GLOBE trial results: Telbivudine is superior to lamivudine in patients with chronic hepatitis B
    • Liaw YF, Gane E, Leung N, et al. 2-Year GLOBE trial results: telbivudine is superior to lamivudine in patients with chronic hepatitis B. Gastroenterology 2009; 136: 486-95.
    • (2009) Gastroenterology , vol.136 , pp. 486-495
    • Liaw, Y.F.1    Gane, E.2    Leung, N.3
  • 35
    • 35649020315 scopus 로고    scopus 로고
    • Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B
    • Gish RG, Lok AS, Chang TT, et al. Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B. Gastroenterology 2007; 133: 1437-44.
    • (2007) Gastroenterology , vol.133 , pp. 1437-1444
    • Gish, R.G.1    Lok, A.S.2    Chang, T.T.3
  • 36
    • 75449107726 scopus 로고    scopus 로고
    • Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B
    • Chang TT, Lai CL, Kew Yoon S, et al. Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B. Hepatology 2010; 51: 422-30.
    • (2010) Hepatology , vol.51 , pp. 422-430
    • Chang, T.T.1    Lai, C.L.2    Kew Yoon, S.3
  • 37
    • 77949874166 scopus 로고    scopus 로고
    • Antiviral effect of entecavir in chronic hepatitis B: Influence of prior exposure to nucleos(t)ide analogues
    • Reijnders JG, Deterding K, Petersen J, et al. Antiviral effect of entecavir in chronic hepatitis B: influence of prior exposure to nucleos(t)ide analogues. J Hepatol 2010; 52: 493-500.
    • (2010) J Hepatol , vol.52 , pp. 493-500
    • Reijnders, J.G.1    Deterding, K.2    Petersen, J.3
  • 38
    • 79251480040 scopus 로고    scopus 로고
    • Effectiveness of entecavir for NUC-naîve, HBeAg-negative chronic hepatitis B patients in clinical practice: A 2-year multicenter cohort study in 311 patients
    • Lampertico P, Vigano M, Facchetti F, et al. Effectiveness of entecavir for NUC-naîve, HBeAg-negative chronic hepatitis B patients in clinical practice: a 2-year multicenter cohort study in 311 patients. J Hepatol 2010; 52 (Suppl. 1): S389-90.
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Lampertico, P.1    Vigano, M.2    Facchetti, F.3
  • 39
    • 66149115173 scopus 로고    scopus 로고
    • Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy
    • Tenney DJ, Rose RE, Baldick CJ, et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy. Hepatology 2009; 49: 1503-14.
    • (2009) Hepatology , vol.49 , pp. 1503-1514
    • Tenney, D.J.1    Rose, R.E.2    Baldick, C.J.3
  • 40
    • 57349095400 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B
    • Marcellin P, Heathcote EJ, Buti M, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med 2008; 359: 2442-55.
    • (2008) N Engl J Med , vol.359 , pp. 2442-2455
    • Marcellin, P.1    Heathcote, E.J.2    Buti, M.3
  • 41
    • 77950613329 scopus 로고    scopus 로고
    • Three years of tenofovir disoproxil (TDF) treatment in HBeAg-positive patients (HBeAg+) with chronic hepatitis B (study 103), preliminary analysis
    • Heathcote EJ, Gane EJ, De Man RA, et al. Three years of tenofovir disoproxil (TDF) treatment in HBeAg-positive patients (HBeAg+) with chronic hepatitis B (study 103), preliminary analysis. Hepatology 2009; 4 (Suppl.): 533A-4A.
    • (2009) Hepatology , vol.4 , Issue.SUPPL.
    • Heathcote, E.J.1    Gane, E.J.2    De Man, R.A.3
  • 42
    • 77956627491 scopus 로고    scopus 로고
    • Three years of tenofovir disoproxil fumarate (TDF) treatment in HBeAg-negative patients with chronic hepatitis B (study 102); Preliminary analysis
    • Marcellin P, Buti M, Krastev Z, et al. Three years of tenofovir disoproxil fumarate (TDF) treatment in HBeAg-negative patients with chronic hepatitis B (study 102); preliminary analysis. Hepatology 2009; 4 (Suppl.): 532A-3A.
    • (2009) Hepatology , vol.4 , Issue.SUPPL.
    • Marcellin, P.1    Buti, M.2    Krastev, Z.3
  • 43
    • 73449121925 scopus 로고    scopus 로고
    • Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues
    • van Bommel F, de Man RA, Wedemeyer H, et al. Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues. Hepatology 2010; 51: 73-80.
    • (2010) Hepatology , vol.51 , pp. 73-80
    • Van Bommel, F.1    De Man, R.A.2    Wedemeyer, H.3
  • 44
    • 0344012054 scopus 로고    scopus 로고
    • Pegylated interferons for chronic hepatitis B
    • Craxi A, Cooksley WG,. Pegylated interferons for chronic hepatitis B. Antiviral Res 2003; 60: 87-9.
    • (2003) Antiviral Res , vol.60 , pp. 87-89
    • Craxi, A.1    Cooksley, W.G.2
  • 45
    • 0038045171 scopus 로고    scopus 로고
    • Peginterferon alpha-2a (40 kDa): An advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • Cooksley WG, Piratvisuth T, Lee SD, et al. Peginterferon alpha-2a (40 kDa): an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B. J Viral Hepat 2003; 10: 298-305.
    • (2003) J Viral Hepat , vol.10 , pp. 298-305
    • Cooksley, W.G.1    Piratvisuth, T.2    Lee, S.D.3
  • 46
    • 19944428132 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: A randomised trial
    • Janssen HL, van Zonneveld M, Senturk H, et al. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet 2005; 365: 123-9.
    • (2005) Lancet , vol.365 , pp. 123-129
    • Janssen, H.L.1    Van Zonneveld, M.2    Senturk, H.3
  • 47
    • 21244447705 scopus 로고    scopus 로고
    • Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B
    • Lau GK, Piratvisuth T, Luo KX, et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med 2005; 352: 2682-95.
    • (2005) N Engl J Med , vol.352 , pp. 2682-2695
    • Lau, G.K.1    Piratvisuth, T.2    Luo, K.X.3
  • 48
    • 48549107919 scopus 로고    scopus 로고
    • Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b
    • Buster EH, Flink HJ, Cakaloglu Y, et al. Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b. Gastroenterology 2008; 135: 459-67.
    • (2008) Gastroenterology , vol.135 , pp. 459-467
    • Buster, E.H.1    Flink, H.J.2    Cakaloglu, Y.3
  • 49
    • 4544239807 scopus 로고    scopus 로고
    • Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B
    • Marcellin P, Lau GK, Bonino F, et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2004; 351: 1206-17.
    • (2004) N Engl J Med , vol.351 , pp. 1206-1217
    • Marcellin, P.1    Lau, G.K.2    Bonino, F.3
  • 50
    • 77958091146 scopus 로고    scopus 로고
    • Extended (2 years) treatment with peginterferon alfa-2a [40 kD] improves sustained response rates in genotype D patients with HBeAg negative chronic hepatitis B
    • Lampertico P, Vigano M, Di Costanzo G, et al. Extended (2 years) treatment with peginterferon alfa-2a [40 kD] improves sustained response rates in genotype D patients with HBeAg negative chronic hepatitis B. J Hepatol 2010; 52 (Suppl. 1): S45.
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Lampertico, P.1    Vigano, M.2    Di Costanzo, G.3
  • 51
    • 66449121130 scopus 로고    scopus 로고
    • Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a
    • Marcellin P, Bonino F, Lau GK, et al. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology 2009; 136: 2169-79.
    • (2009) Gastroenterology , vol.136 , pp. 2169-2179
    • Marcellin, P.1    Bonino, F.2    Lau, G.K.3
  • 52
    • 66149190942 scopus 로고    scopus 로고
    • Side effects of long-term oral antiviral therapy for hepatitis B
    • Fontana RJ,. Side effects of long-term oral antiviral therapy for hepatitis B. Hepatology 2009; 5 (Suppl.): S185-95.
    • (2009) Hepatology , vol.5 , Issue.SUPPL.
    • Fontana, R.J.1
  • 53
    • 0033592764 scopus 로고    scopus 로고
    • Lamivudine as initial treatment for chronic hepatitis B in the United States
    • Dienstag JL, Schiff ER, Wright TL, et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med 1999; 341: 1256-63.
    • (1999) N Engl J Med , vol.341 , pp. 1256-1263
    • Dienstag, J.L.1    Schiff, E.R.2    Wright, T.L.3
  • 54
    • 4344623455 scopus 로고    scopus 로고
    • Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: Two double-blind, randomized, placebo-controlled studies
    • Izzedine H, Hulot JS, Launay-Vacher V, et al. Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebo-controlled studies. Kidney Int 2004; 66: 1153-8.
    • (2004) Kidney Int , vol.66 , pp. 1153-1158
    • Izzedine, H.1    Hulot, J.S.2    Launay-Vacher, V.3
  • 55
    • 20844448900 scopus 로고    scopus 로고
    • The safety of pegylated interferon alpha-2b in the treatment of chronic hepatitis B: Predictive factors for dose reduction and treatment discontinuation
    • van Zonneveld M, Flink HJ, Verhey E, et al. The safety of pegylated interferon alpha-2b in the treatment of chronic hepatitis B: predictive factors for dose reduction and treatment discontinuation. Aliment Pharmacol Ther 2005; 21: 1163-71.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 1163-1171
    • Van Zonneveld, M.1    Flink, H.J.2    Verhey, E.3
  • 56
    • 34548311958 scopus 로고    scopus 로고
    • Peginterferon alpha-2b is safe and effective in HBeAg-positive chronic hepatitis B patients with advanced fibrosis
    • Buster EH, Hansen BE, Buti M, et al. Peginterferon alpha-2b is safe and effective in HBeAg-positive chronic hepatitis B patients with advanced fibrosis. Hepatology 2007; 46: 388-94.
    • (2007) Hepatology , vol.46 , pp. 388-394
    • Buster, E.H.1    Hansen, B.E.2    Buti, M.3
  • 57
    • 77955976756 scopus 로고    scopus 로고
    • Telbivudine (LdT) plus peg-interferon (PEG-IFN) in HBeAg-positive chronic hepatitis B - Very potent antiviral efficacy but risk of peripheral neuropathy
    • Marcellin P, Avila C, Wursthorn K, et al. Telbivudine (LdT) plus peg-interferon (PEG-IFN) in HBeAg-positive chronic hepatitis B-very potent antiviral efficacy but risk of peripheral neuropathy. J Hepatol 2010; 52 (Suppl. 1): S6-7.
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Marcellin, P.1    Avila, C.2    Wursthorn, K.3
  • 58
    • 77955984417 scopus 로고    scopus 로고
    • Pros and cons of peginterferon versus nucleos(t)ide analogues for treatment of chronic hepatitis B
    • Sonneveld MJ, Janssen HL,. Pros and cons of peginterferon versus nucleos(t)ide analogues for treatment of chronic hepatitis B. Curr Hepat Rep 2010; 9: 91-8.
    • (2010) Curr Hepat Rep , vol.9 , pp. 91-98
    • Sonneveld, M.J.1    Janssen, H.L.2
  • 59
    • 34548138876 scopus 로고    scopus 로고
    • Treating chronic hepatitis B infection in patients who are pregnant or are undergoing immunosuppressive chemotherapy
    • Terrault NA, Jacobson IM,. Treating chronic hepatitis B infection in patients who are pregnant or are undergoing immunosuppressive chemotherapy. Semin Liver Dis 2007; 27 (Suppl. 1): 18-24.
    • (2007) Semin Liver Dis , vol.27 , Issue.SUPPL. 1 , pp. 18-24
    • Terrault, N.A.1    Jacobson, I.M.2
  • 60
    • 21044453739 scopus 로고    scopus 로고
    • Response to interferon alfa is hepatitis B virus genotype dependent: Genotype A is more sensitive to interferon than genotype D
    • Erhardt A, Blondin D, Hauck K, et al. Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D. Gut 2005; 54: 1009-13.
    • (2005) Gut , vol.54 , pp. 1009-1013
    • Erhardt, A.1    Blondin, D.2    Hauck, K.3
  • 61
    • 0036896130 scopus 로고    scopus 로고
    • HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C
    • Wai CT, Chu CJ, Hussain M, Lok AS,. HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C. Hepatology 2002; 36: 1425-30.
    • (2002) Hepatology , vol.36 , pp. 1425-1430
    • Wai, C.T.1    Chu, C.J.2    Hussain, M.3    Lok, A.S.4
  • 62
    • 4644305114 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes: Do they play a role in the outcome of HBV infection?
    • Fung SK, Lok AS,. Hepatitis B virus genotypes: do they play a role in the outcome of HBV infection? Hepatology 2004; 40: 790-2.
    • (2004) Hepatology , vol.40 , pp. 790-792
    • Fung, S.K.1    Lok, A.S.2
  • 63
    • 35648994427 scopus 로고    scopus 로고
    • Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F
    • Livingston SE, Simonetti JP, Bulkow LR, et al. Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F. Gastroenterology 2007; 133: 1452-7.
    • (2007) Gastroenterology , vol.133 , pp. 1452-1457
    • Livingston, S.E.1    Simonetti, J.P.2    Bulkow, L.R.3
  • 64
    • 0036892321 scopus 로고    scopus 로고
    • Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients
    • Sanchez-Tapias JM, Costa J, Mas A, Bruguera M, Rodes J,. Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients. Gastroenterology 2002; 123: 1848-56.
    • (2002) Gastroenterology , vol.123 , pp. 1848-1856
    • Sanchez-Tapias, J.M.1    Costa, J.2    Mas, A.3    Bruguera, M.4    Rodes, J.5
  • 65
    • 0036079898 scopus 로고    scopus 로고
    • Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C
    • Chu CJ, Hussain M, Lok AS,. Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002; 122: 1756-62.
    • (2002) Gastroenterology , vol.122 , pp. 1756-1762
    • Chu, C.J.1    Hussain, M.2    Lok, A.S.3
  • 66
    • 70649104668 scopus 로고    scopus 로고
    • Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa
    • Buster EH, Hansen BE, Lau GK, et al. Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa. Gastroenterology 2009; 137: 2002-9.
    • (2009) Gastroenterology , vol.137 , pp. 2002-2009
    • Buster, E.H.1    Hansen, B.E.2    Lau, G.K.3
  • 67
    • 84876033056 scopus 로고    scopus 로고
    • The role of quantitative hepatitis B serology in the natural history and management of chronic hepatitis B
    • Nguyen T, Desmond P, Locarnini S,. The role of quantitative hepatitis B serology in the natural history and management of chronic hepatitis B. Hepatol Int 2009; 3: S5-15.
    • (2009) Hepatol Int , vol.3
    • Nguyen, T.1    Desmond, P.2    Locarnini, S.3
  • 68
    • 39549114267 scopus 로고    scopus 로고
    • HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B
    • Fried MW, Piratvisuth T, Lau GK, et al. HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B. Hepatology 2008; 47: 428-34.
    • (2008) Hepatology , vol.47 , pp. 428-434
    • Fried, M.W.1    Piratvisuth, T.2    Lau, G.K.3
  • 69
    • 77952716572 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen and hepatitis B e antigen titers: Disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers
    • Thompson AJ, Nguyen T, Iser D, et al. Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers. Hepatology 2010; 51: 1933-44.
    • (2010) Hepatology , vol.51 , pp. 1933-1944
    • Thompson, A.J.1    Nguyen, T.2    Iser, D.3
  • 70
    • 36549058611 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response
    • Chan HL, Wong VW, Tse AM, et al. Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response. Clin Gastroenterol Hepatol 2007; 5: 1462-8.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 1462-1468
    • Chan, H.L.1    Wong, V.W.2    Tse, A.M.3
  • 71
    • 2942532722 scopus 로고    scopus 로고
    • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    • Werle-Lapostolle B, Bowden S, Locarnini S, et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 2004; 126: 1750-8.
    • (2004) Gastroenterology , vol.126 , pp. 1750-1758
    • Werle-Lapostolle, B.1    Bowden, S.2    Locarnini, S.3
  • 72
    • 33748929265 scopus 로고    scopus 로고
    • Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
    • Wursthorn K, Lutgehetmann M, Dandri M, et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology 2006; 44: 675-84.
    • (2006) Hepatology , vol.44 , pp. 675-684
    • Wursthorn, K.1    Lutgehetmann, M.2    Dandri, M.3
  • 73
    • 70449495525 scopus 로고    scopus 로고
    • On-treatment monitoring of HBsAg levels to predict response to peginterferon alfa-2a in patients with HBeAg-positive chronic hepatitis B
    • Lau GKK, Marcellin P, Brunetto M, et al. On-treatment monitoring of HBsAg levels to predict response to peginterferon alfa-2a in patients with HBeAg-positive chronic hepatitis B. J Hepatol 2009; 50 (Suppl. 1): S333.
    • (2009) J Hepatol , vol.50 , Issue.SUPPL. 1
    • Lau, G.K.K.1    Marcellin, P.2    Brunetto, M.3
  • 74
    • 77957958049 scopus 로고    scopus 로고
    • Prediction of sustained response to peginterferon alfa-2b for hepatitis B e antigen-positive chronic hepatitis B using on-treatment hepatitis B surface antigen decline
    • Sonneveld MJ, Rijckborst V, Boucher CA, Hansen BE, Janssen HL,. Prediction of sustained response to peginterferon alfa-2b for hepatitis B e antigen-positive chronic hepatitis B using on-treatment hepatitis B surface antigen decline. Hepatology 2010; 52: 1251-7.
    • (2010) Hepatology , vol.52 , pp. 1251-1257
    • Sonneveld, M.J.1    Rijckborst, V.2    Boucher, C.A.3    Hansen, B.E.4    Janssen, H.L.5
  • 75
    • 34247538953 scopus 로고    scopus 로고
    • Predicting response to peginterferon alpha-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B
    • Bonino F, Marcellin P, Lau GK, et al. Predicting response to peginterferon alpha-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B. Gut 2007; 56: 699-705.
    • (2007) Gut , vol.56 , pp. 699-705
    • Bonino, F.1    Marcellin, P.2    Lau, G.K.3
  • 76
    • 77955703978 scopus 로고    scopus 로고
    • Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels
    • Rijckborst V, Hansen BE, Cakaloglu Y, et al. Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels. Hepatology 2010; 52: 454-61.
    • (2010) Hepatology , vol.52 , pp. 454-461
    • Rijckborst, V.1    Hansen, B.E.2    Cakaloglu, Y.3
  • 77
    • 65449117946 scopus 로고    scopus 로고
    • Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B
    • Brunetto MR, Moriconi F, Bonino F, et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology 2009; 49: 1141-50.
    • (2009) Hepatology , vol.49 , pp. 1141-1150
    • Brunetto, M.R.1    Moriconi, F.2    Bonino, F.3
  • 78
    • 65449123444 scopus 로고    scopus 로고
    • Early serum HBsAg drop: A strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients
    • Moucari R, Mackiewicz V, Lada O, et al. Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology 2009; 49: 1151-7.
    • (2009) Hepatology , vol.49 , pp. 1151-1157
    • Moucari, R.1    MacKiewicz, V.2    Lada, O.3
  • 79
    • 77957331059 scopus 로고    scopus 로고
    • Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: A systematic review and bayesian meta-analyses
    • Woo G, Tomlinson G, Nishikawa Y, et al. Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and bayesian meta-analyses. Gastroenterology 2010; 139: 1218-29.
    • (2010) Gastroenterology , vol.139 , pp. 1218-1229
    • Woo, G.1    Tomlinson, G.2    Nishikawa, Y.3
  • 80
    • 70349263455 scopus 로고    scopus 로고
    • Potential impact of long-term nucleoside therapy on the mortality and morbidity of active chronic hepatitis B
    • Toy M, Veldhuijzen IK, de Man RA, Richardus JH, Schalm SW,. Potential impact of long-term nucleoside therapy on the mortality and morbidity of active chronic hepatitis B. Hepatology 2009; 50: 743-51.
    • (2009) Hepatology , vol.50 , pp. 743-751
    • Toy, M.1    Veldhuijzen, I.K.2    De Man, R.A.3    Richardus, J.H.4    Schalm, S.W.5
  • 81
    • 69949132951 scopus 로고    scopus 로고
    • Modeling the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B
    • Buti M, Brosa M, Casado MA, Rueda M, Esteban R,. Modeling the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B. J Hepatol 2009; 51: 640-6.
    • (2009) J Hepatol , vol.51 , pp. 640-646
    • Buti, M.1    Brosa, M.2    Casado, M.A.3    Rueda, M.4    Esteban, R.5
  • 82
    • 77950670544 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of roadmap models in chronic hepatitis B using tenofovir as the rescue therapy
    • Lui YY, Tsoi KK, Wong VW, et al. Cost-effectiveness analysis of roadmap models in chronic hepatitis B using tenofovir as the rescue therapy. Antivir Ther 2010; 15: 145-55.
    • (2010) Antivir Ther , vol.15 , pp. 145-155
    • Lui, Y.Y.1    Tsoi, K.K.2    Wong, V.W.3
  • 83
    • 67349178133 scopus 로고    scopus 로고
    • Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B
    • Zeuzem S, Gane E, Liaw YF, et al. Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B. J Hepatol 2009; 51: 11-20.
    • (2009) J Hepatol , vol.51 , pp. 11-20
    • Zeuzem, S.1    Gane, E.2    Liaw, Y.F.3
  • 84
    • 0034802516 scopus 로고    scopus 로고
    • Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy
    • Yuen MF, Sablon E, Hui CK, Yuan HJ, Decraemer H, Lai CL,. Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy. Hepatology 2001; 34: 785-91.
    • (2001) Hepatology , vol.34 , pp. 785-791
    • Yuen, M.F.1    Sablon, E.2    Hui, C.K.3    Yuan, H.J.4    Decraemer, H.5    Lai, C.L.6
  • 85
    • 34547148385 scopus 로고    scopus 로고
    • Report of an international workshop: Roadmap for management of patients receiving oral therapy for chronic hepatitis B
    • Keeffe EB, Zeuzem S, Koff RS, et al. Report of an international workshop: roadmap for management of patients receiving oral therapy for chronic hepatitis B. Clin Gastroenterol Hepatol 2007; 5: 890-7.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 890-897
    • Keeffe, E.B.1    Zeuzem, S.2    Koff, R.S.3
  • 86
    • 67349115364 scopus 로고    scopus 로고
    • Treatment with nucleos(t)ide analogues in chronic hepatitis B: Where does the road map lead us?
    • Janssen HL, Reijnders JG,. Treatment with nucleos(t)ide analogues in chronic hepatitis B: where does the road map lead us? J Hepatol 2009; 51: 1-3.
    • (2009) J Hepatol , vol.51 , pp. 1-3
    • Janssen, H.L.1    Reijnders, J.G.2
  • 87
    • 0037381547 scopus 로고    scopus 로고
    • Durability of serologic response after lamivudine treatment of chronic hepatitis B
    • Dienstag JL, Cianciara J, Karayalcin S, et al. Durability of serologic response after lamivudine treatment of chronic hepatitis B. Hepatology 2003; 37: 748-55.
    • (2003) Hepatology , vol.37 , pp. 748-755
    • Dienstag, J.L.1    Cianciara, J.2    Karayalcin, S.3
  • 88
    • 0033797827 scopus 로고    scopus 로고
    • Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea
    • Song BC, Suh DJ, Lee HC, Chung YH, Lee YS,. Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. Hepatology 2000; 32: 803-6.
    • (2000) Hepatology , vol.32 , pp. 803-806
    • Song, B.C.1    Suh, D.J.2    Lee, H.C.3    Chung, Y.H.4    Lee, Y.S.5
  • 89
    • 77955485392 scopus 로고    scopus 로고
    • Nucleos(t)ide analogues only induce temporary hepatitis B e antigen seroconversion in most patients with chronic hepatitis B
    • Reijnders JG, Perquin MJ, Zhang N, Hansen BE, Janssen HL,. Nucleos(t)ide analogues only induce temporary hepatitis B e antigen seroconversion in most patients with chronic hepatitis B. Gastroenterology 2010; 139: 491-8.
    • (2010) Gastroenterology , vol.139 , pp. 491-498
    • Reijnders, J.G.1    Perquin, M.J.2    Zhang, N.3    Hansen, B.E.4    Janssen, H.L.5
  • 90
    • 33748951529 scopus 로고    scopus 로고
    • Patterns of viral decline during PEG-interferon alpha-2b therapy in HBeAg-positive chronic hepatitis B: Relation to treatment response
    • ter Borg MJ, van Zonneveld M, Zeuzem S, et al. Patterns of viral decline during PEG-interferon alpha-2b therapy in HBeAg-positive chronic hepatitis B: relation to treatment response. Hepatology 2006; 44: 721-7.
    • (2006) Hepatology , vol.44 , pp. 721-727
    • Ter Borg, M.J.1    Van Zonneveld, M.2    Zeuzem, S.3
  • 91
    • 33644554733 scopus 로고    scopus 로고
    • On-treatment predictors of sustained biochemical and virological response in patients with HBeAg-negative chronic hepatitis B (CHB) treated with peginterferon alpha-2a (40kDa) (Pegasys(R))
    • Farci P, Marcellin P, Lu ZM, Diago M, Lai MY, Gurel S,. On-treatment predictors of sustained biochemical and virological response in patients with HBeAg-negative chronic hepatitis B (CHB) treated with peginterferon alpha-2a (40kDa) (Pegasys(R)). J Hepatol 2005; 42 (Suppl. 2): S175.
    • (2005) J Hepatol , vol.42 , Issue.SUPPL. 2
    • Farci, P.1    Marcellin, P.2    Lu, Z.M.3    Diago, M.4    Lai, M.Y.5    Gurel, S.6
  • 92
    • 0030567824 scopus 로고    scopus 로고
    • Delta: A randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals
    • Delta Coordinating Committee.
    • Delta Coordinating Committee. Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet 1996; 348: 283-91.
    • (1996) Lancet , vol.348 , pp. 283-291
  • 93
    • 73449142131 scopus 로고    scopus 로고
    • A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen-negative chronic hepatitis B
    • Piccolo P, Lenci I, Demelia L, et al. A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen-negative chronic hepatitis B. Antivir Ther 2009; 14: 1165-74.
    • (2009) Antivir Ther , vol.14 , pp. 1165-1174
    • Piccolo, P.1    Lenci, I.2    Demelia, L.3
  • 94
    • 77955383602 scopus 로고    scopus 로고
    • A randomized trial of peginterferon alfa-2a with or without ribavirin for HBeAg-negative chronic hepatitis B
    • Rijckborst V, Ter Borg MJ, Cakaloglu Y, et al. A randomized trial of peginterferon alfa-2a with or without ribavirin for HBeAg-negative chronic hepatitis B. Am J Gastroenterol 2010; 105: 1762-9.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1762-1769
    • Rijckborst, V.1    Ter Borg, M.J.2    Cakaloglu, Y.3
  • 95
    • 33846080133 scopus 로고    scopus 로고
    • Effect of lowering HBV DNA levels by initial antiviral therapy before adding immunomodulator on treatment of chronic hepatitis B
    • Sarin SK, Sood A, Kumar M, et al. Effect of lowering HBV DNA levels by initial antiviral therapy before adding immunomodulator on treatment of chronic hepatitis B. Am J Gastroenterol 2007; 102: 96-104.
    • (2007) Am J Gastroenterol , vol.102 , pp. 96-104
    • Sarin, S.K.1    Sood, A.2    Kumar, M.3
  • 96
    • 34547755458 scopus 로고    scopus 로고
    • Virological response to different combination regimes of peginterferon alpha-2b and lamivudine in hepatitis B e antigen positive chronic hepatitis B
    • Chan HL, Wong VW, Chim AM, et al. Virological response to different combination regimes of peginterferon alpha-2b and lamivudine in hepatitis B e antigen positive chronic hepatitis B. Antivir Ther 2007; 12: 815-23.
    • (2007) Antivir Ther , vol.12 , pp. 815-823
    • Chan, H.L.1    Wong, V.W.2    Chim, A.M.3
  • 97
    • 40849091053 scopus 로고    scopus 로고
    • Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B
    • Sung JJ, Lai JY, Zeuzem S, et al. Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B. J Hepatol 2008; 48: 728-35.
    • (2008) J Hepatol , vol.48 , pp. 728-735
    • Sung, J.J.1    Lai, J.Y.2    Zeuzem, S.3
  • 98
    • 40849132370 scopus 로고    scopus 로고
    • 96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B
    • Hui CK, Zhang HY, Bowden S, et al. 96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B. J Hepatol 2008; 48: 714-20.
    • (2008) J Hepatol , vol.48 , pp. 714-720
    • Hui, C.K.1    Zhang, H.Y.2    Bowden, S.3
  • 99
    • 23244453590 scopus 로고    scopus 로고
    • A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B
    • Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology 2005; 129: 528-36.
    • (2005) Gastroenterology , vol.129 , pp. 528-536
    • Lai, C.L.1    Leung, N.2    Teo, E.K.3
  • 100
    • 77957376794 scopus 로고    scopus 로고
    • Tenofovir is effective alone or with emtricitabine in adefovir-treated patients with chronic-hepatitis B virus infection
    • Berg T, Marcellin P, Zoulim F, et al. Tenofovir is effective alone or with emtricitabine in adefovir-treated patients with chronic-hepatitis B virus infection. Gastroenterology 2010; 139: 1207-17.
    • (2010) Gastroenterology , vol.139 , pp. 1207-1217
    • Berg, T.1    Marcellin, P.2    Zoulim, F.3


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