Exacerbated innate host response to SARS-CoV in aged non-human primates

PLoS Pathogens

Volumn 6, Issue 2, 2010, Pages

  Smits, Saskia L ^a   De Lang, Anna ^a   Van Den Brand, Judith M A ^a   Leijten, Lonneke M ^a   Van Ijcken, Wilfred F ^a   Eijkemans, Marinus J C ^a   Van Amerongen, Geert ^a   Kuiken, Thijs ^a   Andeweg, Arno C ^a   Osterhaus, Albert D M E ^a   Haagmans, Bart L ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; PEGINTERFERON ALPHA; ANTIINFLAMMATORY AGENT; INTERFERON;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; GENE EXPRESSION; GENOME ANALYSIS; GROUPS BY AGE; HISTOPATHOLOGY; INFECTION SENSITIVITY; INFLAMMATION; INNATE IMMUNITY; MACACA; NONHUMAN; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS IMMUNITY; VIRUS REPLICATION; ACUTE LUNG INJURY; AGING; ANIMAL; BIOSYNTHESIS; DNA MICROARRAY; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VIROLOGY;

ANIMALIA; MACACA; PRIMATES; SARS CORONAVIRUS;

ACUTE LUNG INJURY; AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS; GENE EXPRESSION; GENE EXPRESSION PROFILING; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERFERON TYPE I; INTERLEUKIN-8; MACACA; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

EID: 77649256469     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000756     Document Type: Article

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