-
1
-
-
67649872364
-
Engineered protein scaffolds as next-generation antibody therapeutics
-
10.1016/j.cbpa.2009.04.627, 19501012
-
Gebauer M, Skerra A. Engineered protein scaffolds as next-generation antibody therapeutics. Curr Opin Chem Biol 2009, 13:245-255. 10.1016/j.cbpa.2009.04.627, 19501012.
-
(2009)
Curr Opin Chem Biol
, vol.13
, pp. 245-255
-
-
Gebauer, M.1
Skerra, A.2
-
2
-
-
77950787098
-
Alternative antibody formats
-
Kontermann RE. Alternative antibody formats. Curr Opin Mol Ther 2010, 12:176-183.
-
(2010)
Curr Opin Mol Ther
, vol.12
, pp. 176-183
-
-
Kontermann, R.E.1
-
3
-
-
79959565499
-
Recent patent applications in antibody fragments
-
Editorial
-
Editorial Recent patent applications in antibody fragments. Nat Biotechnol 2009, 27:41. Editorial.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 41
-
-
-
4
-
-
68349117269
-
Single domain antibodies: promising experimental and therapeutic tools in infection and immunity
-
Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, Cauerhff A, Danquah W, Rissiek B, Scheuplein F, Schwarz N, Adriouch S, Boyer O, Seman M, Licea A, Serreze DV, Goldbaum FA, Haag F, Koch-Nolte F. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity. Mol Microbiol Immunol 2009, 198:157-174.
-
(2009)
Mol Microbiol Immunol
, vol.198
, pp. 157-174
-
-
Wesolowski, J.1
Alzogaray, V.2
Reyelt, J.3
Unger, M.4
Juarez, K.5
Urrutia, M.6
Cauerhff, A.7
Danquah, W.8
Rissiek, B.9
Scheuplein, F.10
Schwarz, N.11
Adriouch, S.12
Boyer, O.13
Seman, M.14
Licea, A.15
Serreze, D.V.16
Goldbaum, F.A.17
Haag, F.18
Koch-Nolte, F.19
-
5
-
-
33645056478
-
Antibody targeted drugs a cancer therapeutics
-
Schrama D, Reisfeld RA, Becker JC. Antibody targeted drugs a cancer therapeutics. Nat Rev 2006, 5:147-159.
-
(2006)
Nat Rev
, vol.5
, pp. 147-159
-
-
Schrama, D.1
Reisfeld, R.A.2
Becker, J.C.3
-
6
-
-
62149129236
-
Therapeutic antibodies: successes, limitations and hopes for the future
-
Chames P, Van Regenmortel M, Weiss E, Baty D. Therapeutic antibodies: successes, limitations and hopes for the future. Brit J Pharmacol 2009, 157:220-233.
-
(2009)
Brit J Pharmacol
, vol.157
, pp. 220-233
-
-
Chames, P.1
Van Regenmortel, M.2
Weiss, E.3
Baty, D.4
-
7
-
-
34548583912
-
SPR biosensor for the detection of L. monocytogenes using phage-displayed antibody
-
10.1016/j.bios.2007.04.007, 17512186
-
Nanduri V, Bhunia AK, Tu S-I, Paoli GC, Brewster JD. SPR biosensor for the detection of L. monocytogenes using phage-displayed antibody. Biosens Bioelectron 2007, 23:248-252. 10.1016/j.bios.2007.04.007, 17512186.
-
(2007)
Biosens Bioelectron
, vol.23
, pp. 248-252
-
-
Nanduri, V.1
Bhunia, A.K.2
Tu, S.-I.3
Paoli, G.C.4
Brewster, J.D.5
-
8
-
-
28244432240
-
The blood-brain barrier transmigrating single domain antibody: mechanism of transport and antigenic epitopes in human brain endothelial cells
-
10.1111/j.1471-4159.2005.03463.x, 16271053
-
Abulrob A, Sprong H, Van Bergen en Henegouwen P, Stanimirovic D. The blood-brain barrier transmigrating single domain antibody: mechanism of transport and antigenic epitopes in human brain endothelial cells. J Neurochem 2005, 95:1201-1214. 10.1111/j.1471-4159.2005.03463.x, 16271053.
-
(2005)
J Neurochem
, vol.95
, pp. 1201-1214
-
-
Abulrob, A.1
Sprong, H.2
Van Bergen en Henegouwen, P.3
Stanimirovic, D.4
-
9
-
-
77952807445
-
Kinetic analysis of novel mono-and multivalent VHH-fragments and their application for molecular imaging of brain tumours
-
2936006, 20590596
-
Iqbal U, Trojahn U, Albaghdadi H, Zhang J, O'Connor-McCourt M, Stanimirovic D, Tomanek B, Sutherland G, Abulrob A. Kinetic analysis of novel mono-and multivalent VHH-fragments and their application for molecular imaging of brain tumours. Br J Pharmacol 2010, 160:1016-1028. 2936006, 20590596.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1016-1028
-
-
Iqbal, U.1
Trojahn, U.2
Albaghdadi, H.3
Zhang, J.4
O'Connor-McCourt, M.5
Stanimirovic, D.6
Tomanek, B.7
Sutherland, G.8
Abulrob, A.9
-
10
-
-
0037225784
-
Immunomodulation of enzyme function in plants by single-domain antibody fragments
-
10.1038/nbt772, 12483224
-
Jobling SA, Jarman C, The M-M, Holmberg N, Blake C, Verhoeyen E. Immunomodulation of enzyme function in plants by single-domain antibody fragments. Nat Biotechnol 2003, 21:77-80. 10.1038/nbt772, 12483224.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 77-80
-
-
Jobling, S.A.1
Jarman, C.2
The, M.-M.3
Holmberg, N.4
Blake, C.5
Verhoeyen, E.6
-
11
-
-
59949088708
-
Selection and characterization of KDEL-specific VHH antibody fragments and their application in the study of ER resident protein expression
-
Klooster R, Eman R, le Duc Q, Verheesen P, Verrips T, Roovers RC, Post JA. Selection and characterization of KDEL-specific VHH antibody fragments and their application in the study of ER resident protein expression. J Immunol Meth 2009, 342:1-12.
-
(2009)
J Immunol Meth
, vol.342
, pp. 1-12
-
-
Klooster, R.1
Eman, R.2
le Duc, Q.3
Verheesen, P.4
Verrips, T.5
Roovers, R.C.6
Post, J.A.7
-
12
-
-
72449149293
-
Protein mislocalization in plant cells using a GFP-binding chromobody
-
10.1111/j.1365-313X.2009.03982.x, 19686537
-
Schornack S, Fuchs R, Huitema E, Rothbauer U, Lipka V, Kamoun S. Protein mislocalization in plant cells using a GFP-binding chromobody. Plant J 2009, 60:744-754. 10.1111/j.1365-313X.2009.03982.x, 19686537.
-
(2009)
Plant J
, vol.60
, pp. 744-754
-
-
Schornack, S.1
Fuchs, R.2
Huitema, E.3
Rothbauer, U.4
Lipka, V.5
Kamoun, S.6
-
13
-
-
77449102676
-
Modulation of protein properties in living cells using nanobodies
-
10.1038/nsmb.1727, 20010839
-
Kirchhofer A, Helma J, Schmidthals K, Frauer C, Cui S, Karcher A, Pellis M, Muyldermans S, Casas-Delucchi CS, Cardoso MC, Leonhardt H, Hopfner KP, Rothbauer U. Modulation of protein properties in living cells using nanobodies. Nat Struct Mol Biol 2010, 17:133-138. 10.1038/nsmb.1727, 20010839.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 133-138
-
-
Kirchhofer, A.1
Helma, J.2
Schmidthals, K.3
Frauer, C.4
Cui, S.5
Karcher, A.6
Pellis, M.7
Muyldermans, S.8
Casas-Delucchi, C.S.9
Cardoso, M.C.10
Leonhardt, H.11
Hopfner, K.P.12
Rothbauer, U.13
-
14
-
-
70449529499
-
Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies
-
10.1007/s00401-009-0572-6, 19597828
-
Perrucchini C, Pecorari F, Bourgeois J-P, Duyckaerts C, Rougeon F, Lafaye P. Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies. Acta Neuropathol 2009, 118:685-695. 10.1007/s00401-009-0572-6, 19597828.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 685-695
-
-
Perrucchini, C.1
Pecorari, F.2
Bourgeois, J.-P.3
Duyckaerts, C.4
Rougeon, F.5
Lafaye, P.6
-
15
-
-
67650236125
-
A llama single domain anti-idiotypic antibody mimicking HER2 as a vaccine: Immunogenicity and efficacy
-
10.1016/j.vaccine.2009.05.067, 19523913
-
Alvarez-Rueda N, Ladjemi MZ, Behar G, Corgnac S, Pugniere M, Roquet F, Bascoul-Mollevi C, Baty D, Pèlegrin A, Navarro-Teulon I. A llama single domain anti-idiotypic antibody mimicking HER2 as a vaccine: Immunogenicity and efficacy. Vaccine 2009, 27:4826-4833. 10.1016/j.vaccine.2009.05.067, 19523913.
-
(2009)
Vaccine
, vol.27
, pp. 4826-4833
-
-
Alvarez-Rueda, N.1
Ladjemi, M.Z.2
Behar, G.3
Corgnac, S.4
Pugniere, M.5
Roquet, F.6
Bascoul-Mollevi, C.7
Baty, D.8
Pèlegrin, A.9
Navarro-Teulon, I.10
-
16
-
-
77956717843
-
Nanobodies®: proficient tools in diagnostic
-
10.1586/erm.10.62, 20843201
-
Huang L, Muyldermans S, Saerens D. Nanobodies®: proficient tools in diagnostic. Expert Rev Mol Diagn 2010, 10:777-785. 10.1586/erm.10.62, 20843201.
-
(2010)
Expert Rev Mol Diagn
, vol.10
, pp. 777-785
-
-
Huang, L.1
Muyldermans, S.2
Saerens, D.3
-
17
-
-
41249087476
-
Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains
-
Barthelemy PA, Raab H, Appleton BA, Bond CJ, Wu P, Wiesmann C, Sidhu SS. Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains. J Biol Chem 2008, 283:3639-3554.
-
(2008)
J Biol Chem
, vol.283
, pp. 3639-13554
-
-
Barthelemy, P.A.1
Raab, H.2
Appleton, B.A.3
Bond, C.J.4
Wu, P.5
Wiesmann, C.6
Sidhu, S.S.7
-
18
-
-
1642364974
-
Crystal structure of HEL4, a soluble, refoldable human VH single domain with germ-line scaffold
-
10.1016/j.jmb.2004.02.013, 15033359
-
Jespers L, Schon O, James LC, Veprintsev D, Winter G. Crystal structure of HEL4, a soluble, refoldable human VH single domain with germ-line scaffold. J Mol Biol 2004, 337:893-903. 10.1016/j.jmb.2004.02.013, 15033359.
-
(2004)
J Mol Biol
, vol.337
, pp. 893-903
-
-
Jespers, L.1
Schon, O.2
James, L.C.3
Veprintsev, D.4
Winter, G.5
-
19
-
-
0042736849
-
A structure-based database of antibody variable domain diversity
-
10.1016/S0022-2836(03)00967-7, 12963373
-
Bond CJ, Marsters JC, Sidhu SS. A structure-based database of antibody variable domain diversity. J Mol Biol 2003, 332:643-655. 10.1016/S0022-2836(03)00967-7, 12963373.
-
(2003)
J Mol Biol
, vol.332
, pp. 643-655
-
-
Bond, C.J.1
Marsters, J.C.2
Sidhu, S.S.3
-
20
-
-
29244442688
-
Isolation of monomeric human VHs by a phage selection
-
10.1074/jbc.M509900200, 16221664
-
To R, Hirama T, Arbabi-Ghahroudi M, MacKenzie R, Wang P, Xu P, Ni F, Tanha J. Isolation of monomeric human VHs by a phage selection. J Biol Chem 2005, 280:41395-41403. 10.1074/jbc.M509900200, 16221664.
-
(2005)
J Biol Chem
, vol.280
, pp. 41395-41403
-
-
To, R.1
Hirama, T.2
Arbabi-Ghahroudi, M.3
MacKenzie, R.4
Wang, P.5
Xu, P.6
Ni, F.7
Tanha, J.8
-
21
-
-
50149083288
-
Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain
-
10.1016/j.jmb.2008.07.054, 2551765, 18687338
-
Chen W, Zhu Z, Feng Y, Xiao X, Dimitrov DS. Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain. J Mol Biol 2008, 382:779-789. 10.1016/j.jmb.2008.07.054, 2551765, 18687338.
-
(2008)
J Mol Biol
, vol.382
, pp. 779-789
-
-
Chen, W.1
Zhu, Z.2
Feng, Y.3
Xiao, X.4
Dimitrov, D.S.5
-
22
-
-
4444302074
-
Aggregation-resistant domain antibodies selected on phage by heat denaturation
-
10.1038/nbt1000, 15300256
-
Jespers L, Schon O, Famm K, Winter G. Aggregation-resistant domain antibodies selected on phage by heat denaturation. Nat Biotechnol 2004, 22:1161-1165. 10.1038/nbt1000, 15300256.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 1161-1165
-
-
Jespers, L.1
Schon, O.2
Famm, K.3
Winter, G.4
-
23
-
-
13644264347
-
A step ahead: combining protein purification and correct folding selection
-
10.1186/1475-2859-3-12, 524515, 15471550
-
de Marco A. A step ahead: combining protein purification and correct folding selection. Microb Cell Fact 2004, 3:12. 10.1186/1475-2859-3-12, 524515, 15471550.
-
(2004)
Microb Cell Fact
, vol.3
, pp. 12
-
-
de Marco, A.1
-
24
-
-
0029070931
-
Solution properties of Escherichia coli-expressed VH domain of anti-neuraminidase antibody NC41
-
Kortt AA, Guthrie RE, Hinds MG, Power BE, Ivancic N, Caldwell JB, Gruen LC, Norton RS, Hudson PJ. Solution properties of Escherichia coli-expressed VH domain of anti-neuraminidase antibody NC41. J Prot Chem 1995, 14:167-178.
-
(1995)
J Prot Chem
, vol.14
, pp. 167-178
-
-
Kortt, A.A.1
Guthrie, R.E.2
Hinds, M.G.3
Power, B.E.4
Ivancic, N.5
Caldwell, J.B.6
Gruen, L.C.7
Norton, R.S.8
Hudson, P.J.9
-
25
-
-
0024461313
-
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
-
10.1038/341544a0, 2677748
-
Ward ES, Güssow D, Griffiths AD, Jones PT, Winter G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 1989, 341:544-546. 10.1038/341544a0, 2677748.
-
(1989)
Nature
, vol.341
, pp. 544-546
-
-
Ward, E.S.1
Güssow, D.2
Griffiths, A.D.3
Jones, P.T.4
Winter, G.5
-
26
-
-
0032763794
-
An antibody single-domain phage display library of a native heavy chain variable region: isolation of functional single-domain VH molecules with a unique interface
-
10.1006/jmbi.1999.2923, 10395823
-
Reiter Y, Schuck P, Boyd LF, Plaskin D. An antibody single-domain phage display library of a native heavy chain variable region: isolation of functional single-domain VH molecules with a unique interface. J Mol Biol 1999, 290:685-698. 10.1006/jmbi.1999.2923, 10395823.
-
(1999)
J Mol Biol
, vol.290
, pp. 685-698
-
-
Reiter, Y.1
Schuck, P.2
Boyd, L.F.3
Plaskin, D.4
-
27
-
-
0029665877
-
A melanoma-specific VH antibody cloned from a fusion phage library of a vaccinated melanoma patient
-
10.1073/pnas.93.13.6280, 39013, 8692806
-
Cai X, Garen A. A melanoma-specific VH antibody cloned from a fusion phage library of a vaccinated melanoma patient. Proc Natl Acad Sci USA 1996, 93:6280-6285. 10.1073/pnas.93.13.6280, 39013, 8692806.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6280-6285
-
-
Cai, X.1
Garen, A.2
-
28
-
-
0036570726
-
Selection by phage display of llama conventional VH fragments with heavy chain antibody VHH properties
-
10.1016/S0022-1759(02)00027-3, 12009207
-
Tanha J, Dubue G, Hirama T, Narang SA, MacKenzie CR. Selection by phage display of llama conventional VH fragments with heavy chain antibody VHH properties. J Immunol Methods 2002, 263:97-109. 10.1016/S0022-1759(02)00027-3, 12009207.
-
(2002)
J Immunol Methods
, vol.263
, pp. 97-109
-
-
Tanha, J.1
Dubue, G.2
Hirama, T.3
Narang, S.A.4
MacKenzie, C.R.5
-
29
-
-
65349172055
-
Immunological applications of single domain llama recombinant antibodies isolated from a naïve library
-
Monegal A, Ami D, Martinelli C, Huang H, Aliprandi M, Francavilla C, Ossolengo G, de Marco A. Immunological applications of single domain llama recombinant antibodies isolated from a naïve library. Prot Engineer Des Sel 2009, 22:273-280.
-
(2009)
Prot Engineer Des Sel
, vol.22
, pp. 273-280
-
-
Monegal, A.1
Ami, D.2
Martinelli, C.3
Huang, H.4
Aliprandi, M.5
Francavilla, C.6
Ossolengo, G.7
de Marco, A.8
-
30
-
-
37549052817
-
Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice
-
10.1084/jem.20071155, 2150980, 18086860
-
Zou X, Osborn MJ, Bolland DJ, Smith JA, Corcos D, Hamon M, Oxley D, Hutchings A, Morgan G, Santos F, Kilshaw PJ, Taussig MJ, Corcoran AE, Brüggemann M. Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice. J Exp Med 2007, 204:3271-3283. 10.1084/jem.20071155, 2150980, 18086860.
-
(2007)
J Exp Med
, vol.204
, pp. 3271-3283
-
-
Zou, X.1
Osborn, M.J.2
Bolland, D.J.3
Smith, J.A.4
Corcos, D.5
Hamon, M.6
Oxley, D.7
Hutchings, A.8
Morgan, G.9
Santos, F.10
Kilshaw, P.J.11
Taussig, M.J.12
Corcoran, A.E.13
Brüggemann, M.14
-
31
-
-
77954739350
-
A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire
-
10.4049/jimmunol.0903722, 20404276, Muyldermans
-
Deschacht N, De Groeve K, Vincke C, Raes G, De Baetselier P, . Muyldermans A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire. J Immunol 2010, 184:5696-5704. 10.4049/jimmunol.0903722, 20404276, Muyldermans.
-
(2010)
J Immunol
, vol.184
, pp. 5696-5704
-
-
Deschacht, N.1
De Groeve, K.2
Vincke, C.3
Raes, G.4
De Baetselier, P.5
-
32
-
-
0043123378
-
Single domain intracellular antibodies: A minimal fragment for direct in vivo selection of antigen-specific intrabodies
-
10.1016/S0022-2836(03)00836-2, 12927545
-
Tanaka T, Lobato MN, Rabbitts TH. Single domain intracellular antibodies: A minimal fragment for direct in vivo selection of antigen-specific intrabodies. J Mol Biol 2003, 331:1109-1120. 10.1016/S0022-2836(03)00836-2, 12927545.
-
(2003)
J Mol Biol
, vol.331
, pp. 1109-1120
-
-
Tanaka, T.1
Lobato, M.N.2
Rabbitts, T.H.3
-
33
-
-
79952798245
-
Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain
-
10.1074/jbc.M110.188193, 20980262
-
Tanaka T, Sewell H, Waters S, Phillips SE, Rabbits TH. Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain. J Biol Chem 2011, 286:3707-3716. 10.1074/jbc.M110.188193, 20980262.
-
(2011)
J Biol Chem
, vol.286
, pp. 3707-3716
-
-
Tanaka, T.1
Sewell, H.2
Waters, S.3
Phillips, S.E.4
Rabbits, T.H.5
-
34
-
-
70349736369
-
A single-step procedure of recombinant library construction for the selection of efficiently produced llama VH binders directed against cancer markers
-
Kastelic D, Frkovič-Grazio S, Baty D, Truan G, Komel R, Pompon D. A single-step procedure of recombinant library construction for the selection of efficiently produced llama VH binders directed against cancer markers. J Immunol Meth 2009, 350:54-62.
-
(2009)
J Immunol Meth
, vol.350
, pp. 54-62
-
-
Kastelic, D.1
Frkovič-Grazio, S.2
Baty, D.3
Truan, G.4
Komel, R.5
Pompon, D.6
-
35
-
-
77951215115
-
A VHH that neutralizes the zinc metalloproteinase activity of botulinum neurotoxin type A
-
10.1074/jbc.M109.073163, 2843216, 20093370
-
Thanongsaksrikul J, Srimanote P, Maneewatch S, Choowongkomon K, Tapchaisri P, Makino S, Kurazono H, Chaicumpa W. A VHH that neutralizes the zinc metalloproteinase activity of botulinum neurotoxin type A. J Biol Chem 2010, 285:9657-9666. 10.1074/jbc.M109.073163, 2843216, 20093370.
-
(2010)
J Biol Chem
, vol.285
, pp. 9657-9666
-
-
Thanongsaksrikul, J.1
Srimanote, P.2
Maneewatch, S.3
Choowongkomon, K.4
Tapchaisri, P.5
Makino, S.6
Kurazono, H.7
Chaicumpa, W.8
-
36
-
-
33751399676
-
Recombinant production of a VL single domain antibody in Escherichia coli and analysis of its interaction with peptostreptococcal protein L
-
Cossins AJ, Harrison S, Popplewell AG, Gore MG. Recombinant production of a VL single domain antibody in Escherichia coli and analysis of its interaction with peptostreptococcal protein L. Prot Expr Purif 2007, 51:253-259.
-
(2007)
Prot Expr Purif
, vol.51
, pp. 253-259
-
-
Cossins, A.J.1
Harrison, S.2
Popplewell, A.G.3
Gore, M.G.4
-
37
-
-
0842313319
-
Fusion of the antiferritin antibody VL domain to barnase results in enhanced solubility and altered pH stability
-
10.1093/protein/gzh011, 14985541
-
Martsev SP, Tsybovsky YI, Stremovskiy OA, Odintsov SG, Balandin TG, Arosio P, Kravchuk ZI, Deyev SM. Fusion of the antiferritin antibody VL domain to barnase results in enhanced solubility and altered pH stability. Protein Eng Des Sel 2004, 17:85-93. 10.1093/protein/gzh011, 14985541.
-
(2004)
Protein Eng Des Sel
, vol.17
, pp. 85-93
-
-
Martsev, S.P.1
Tsybovsky, Y.I.2
Stremovskiy, O.A.3
Odintsov, S.G.4
Balandin, T.G.5
Arosio, P.6
Kravchuk, Z.I.7
Deyev, S.M.8
-
38
-
-
70350302360
-
Single-domain antibody-nanoparticles: Promising architectures for increased Staphylococcus aureus detection specificity and sensitivity
-
Ryan S, Kell AJ, van Faassen H, Tay L-L, Simard B, MacKenzie R, Gilbert M, Tanha J. Single-domain antibody-nanoparticles: Promising architectures for increased Staphylococcus aureus detection specificity and sensitivity. Bioconjugate Chem 2009, 20:1966-1974.
-
(2009)
Bioconjugate Chem
, vol.20
, pp. 1966-1974
-
-
Ryan, S.1
Kell, A.J.2
van Faassen, H.3
Tay, L.-L.4
Simard, B.5
MacKenzie, R.6
Gilbert, M.7
Tanha, J.8
-
39
-
-
70349300140
-
Single-domain antibody-conjugated nanoaggregate-embedded beads for targeted detection of pathogenic bacteria
-
Huang P-J, Tay L-L, Tanha J, Ryan S, Chau L-K. Single-domain antibody-conjugated nanoaggregate-embedded beads for targeted detection of pathogenic bacteria. Chem Eur J 2009, 15:9330-9334.
-
(2009)
Chem Eur J
, vol.15
, pp. 9330-9334
-
-
Huang, P.-J.1
Tay, L.-L.2
Tanha, J.3
Ryan, S.4
Chau, L.-K.5
-
40
-
-
27644445089
-
Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea
-
10.1016/j.vetmic.2005.09.005, 16221532
-
Harmsen MM, van Solt CB, Hoogendoom A, van Zijederveld FG, Niewold TA, van der Meulen J. Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea. Vet Microbiol 2005, 111:89-98. 10.1016/j.vetmic.2005.09.005, 16221532.
-
(2005)
Vet Microbiol
, vol.111
, pp. 89-98
-
-
Harmsen, M.M.1
van Solt, C.B.2
Hoogendoom, A.3
van Zijederveld, F.G.4
Niewold, T.A.5
van der Meulen, J.6
-
41
-
-
33749036261
-
Therapeutic effect of llama derived VHH fragments against Streptococcus mutans on the development of dental caries
-
10.1007/s00253-006-0347-0, 16636830
-
Krüger C, Hultberg A, Marcotte H, Hermans P, Bezemer S, Frenken LGJ, Hammarström L. Therapeutic effect of llama derived VHH fragments against Streptococcus mutans on the development of dental caries. Appl Microbiol Biotechnol 2006, 72:732-737. 10.1007/s00253-006-0347-0, 16636830.
-
(2006)
Appl Microbiol Biotechnol
, vol.72
, pp. 732-737
-
-
Krüger, C.1
Hultberg, A.2
Marcotte, H.3
Hermans, P.4
Bezemer, S.5
Frenken, L.G.J.6
Hammarström, L.7
-
42
-
-
0035989641
-
In situ delivery of passive immunity by lactobacilli producing single-chain antibodies
-
10.1038/nbt0702-702, 12089555
-
Krüger C, Hu Y, Pan Q, Marcotte H, Hultberg A, Delwar D, van Dalen PJ, Pouwels PH, Leer RJ, Kelly CG, van Dollenweerd C, Ma JK, Hammarström L. In situ delivery of passive immunity by lactobacilli producing single-chain antibodies. Nat Biotechnol 2002, 20:702-706. 10.1038/nbt0702-702, 12089555.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 702-706
-
-
Krüger, C.1
Hu, Y.2
Pan, Q.3
Marcotte, H.4
Hultberg, A.5
Delwar, D.6
van Dalen, P.J.7
Pouwels, P.H.8
Leer, R.J.9
Kelly, C.G.10
van Dollenweerd, C.11
Ma, J.K.12
Hammarström, L.13
-
43
-
-
26844528411
-
Passive immunization by lactobacilli expressing single-chain antibodies against Streptococcus mutans
-
10.1385/MB:31:3:221, 16230772
-
Krüger C, Hultberg A, van Dollenweerd C, Marcotte H, Hammarström L. Passive immunization by lactobacilli expressing single-chain antibodies against Streptococcus mutans. Mol Biotechnol 2005, 31:221-231. 10.1385/MB:31:3:221, 16230772.
-
(2005)
Mol Biotechnol
, vol.31
, pp. 221-231
-
-
Krüger, C.1
Hultberg, A.2
van Dollenweerd, C.3
Marcotte, H.4
Hammarström, L.5
-
44
-
-
77249133143
-
Orally administrated L. lactis secreting an anti-TNF nanobody demonstrate efficacy in chronic colitis
-
10.1038/mi.2009.116, 19794409
-
Vandenbroucke K, de Haard H, Beirnaert E, Dreier T, Lauwereys M, Huyck L, Van Huysse J, Demetter P, Steidler L, Remaut E, Cuvelier C, Rottiers P. Orally administrated L. lactis secreting an anti-TNF nanobody demonstrate efficacy in chronic colitis. Mucosal Immunol 2010, 3:49-56. 10.1038/mi.2009.116, 19794409.
-
(2010)
Mucosal Immunol
, vol.3
, pp. 49-56
-
-
Vandenbroucke, K.1
de Haard, H.2
Beirnaert, E.3
Dreier, T.4
Lauwereys, M.5
Huyck, L.6
Van Huysse, J.7
Demetter, P.8
Steidler, L.9
Remaut, E.10
Cuvelier, C.11
Rottiers, P.12
-
45
-
-
4344659634
-
Bacterial effect of a fusion protein of llama heavy-chain antibodies coupled to glucose oxidase on oral bacteria
-
10.1128/AAC.48.9.3390-3395.2004, 514777, 15328101
-
Szynol A, de Soet JJ, Sieben-van Tuyl E, Bos JW, Frenken LG. Bacterial effect of a fusion protein of llama heavy-chain antibodies coupled to glucose oxidase on oral bacteria. Antimicrob Agents Chemother 2004, 48:3390-3395. 10.1128/AAC.48.9.3390-3395.2004, 514777, 15328101.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3390-3395
-
-
Szynol, A.1
de Soet, J.J.2
Sieben-van Tuyl, E.3
Bos, J.W.4
Frenken, L.G.5
-
46
-
-
33747738604
-
Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy
-
10.1007/s00253-005-0300-7, 16450109
-
Harmsen MM, van Solt CB, van Zijederveld-van Bemmel AM, Niewold TA, van Zijederveld FG. Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy. Appl Microbiol Biotechnol 2006, 72:544-551. 10.1007/s00253-005-0300-7, 16450109.
-
(2006)
Appl Microbiol Biotechnol
, vol.72
, pp. 544-551
-
-
Harmsen, M.M.1
van Solt, C.B.2
van Zijederveld-van Bemmel, A.M.3
Niewold, T.A.4
van Zijederveld, F.G.5
-
47
-
-
0034812589
-
Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the Camelidae
-
Conrath KE, Lauwereys M, Galleni M, Matagne A, Frere JM, Kinne J, Wyns L, Muyldermans S. Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the Camelidae. Antimicrob Agents Chemoter 2001, 45:2807-2812.
-
(2001)
Antimicrob Agents Chemoter
, vol.45
, pp. 2807-2812
-
-
Conrath, K.E.1
Lauwereys, M.2
Galleni, M.3
Matagne, A.4
Frere, J.M.5
Kinne, J.6
Wyns, L.7
Muyldermans, S.8
-
48
-
-
0036615345
-
Preventing phage lysis of Lactococcus lactis in cheese production using a neutralizing heavy-chain antibody fragment from llama
-
10.3168/jds.S0022-0302(02)74204-5, 12146467
-
Ledeboer AM, Bezemer S, De Haard HJ, Schaffers IM, Verrips CT, van V, Düsterhöft EM, Zoon P, Moineau S, Frenken LG. Preventing phage lysis of Lactococcus lactis in cheese production using a neutralizing heavy-chain antibody fragment from llama. J Dairy Sci 2002, 85:1376-1382. 10.3168/jds.S0022-0302(02)74204-5, 12146467.
-
(2002)
J Dairy Sci
, vol.85
, pp. 1376-1382
-
-
Ledeboer, A.M.1
Bezemer, S.2
De Haard, H.J.3
Schaffers, I.M.4
Verrips, C.T.5
van, V.6
Düsterhöft, E.M.7
Zoon, P.8
Moineau, S.9
Frenken, L.G.10
-
49
-
-
21144446019
-
Llama antibodies against a lactococcal protein located at the tip of the phage tail prevent phage infection
-
10.1128/JB.187.13.4531-4541.2005, 1151777, 15968064
-
de Haard HJ, Bezemer S, Ledeboer AM, Müller WH, Boender PJ, Moineau S, Coppelmans MC, Verkleij AJ, Frenken LG, Verrips CT. Llama antibodies against a lactococcal protein located at the tip of the phage tail prevent phage infection. J Bacteriol 2005, 187:4531-4541. 10.1128/JB.187.13.4531-4541.2005, 1151777, 15968064.
-
(2005)
J Bacteriol
, vol.187
, pp. 4531-4541
-
-
de Haard, H.J.1
Bezemer, S.2
Ledeboer, A.M.3
Müller, W.H.4
Boender, P.J.5
Moineau, S.6
Coppelmans, M.C.7
Verkleij, A.J.8
Frenken, L.G.9
Verrips, C.T.10
-
50
-
-
35448930317
-
Lactobacilli expressing llama VHH fragments neutralize Lactococcus phages
-
10.1186/1472-6750-7-58, 2039727, 17875214
-
Hultberg A, Tremblay D, de Haard HJ, Verrips T, Moineau S, Hammarström L, Marcotte H. Lactobacilli expressing llama VHH fragments neutralize Lactococcus phages. BMC Biotechnol 2007, 7:58. 10.1186/1472-6750-7-58, 2039727, 17875214.
-
(2007)
BMC Biotechnol
, vol.7
, pp. 58
-
-
Hultberg, A.1
Tremblay, D.2
de Haard, H.J.3
Verrips, T.4
Moineau, S.5
Hammarström, L.6
Marcotte, H.7
-
51
-
-
12244251436
-
Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo
-
10.1128/AEM.71.1.442-450.2005, 544197, 15640220
-
Dolk E, van der Vaart M, Hulsik DL, Vriend G, de Haard HJ, Spinelli S, Cambillau C, Frenken L, Verrips T. Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo. Appl Environ Microbiol 2005, 71:442-450. 10.1128/AEM.71.1.442-450.2005, 544197, 15640220.
-
(2005)
Appl Environ Microbiol
, vol.71
, pp. 442-450
-
-
Dolk, E.1
van der Vaart, M.2
Hulsik, D.L.3
Vriend, G.4
de Haard, H.J.5
Spinelli, S.6
Cambillau, C.7
Frenken, L.8
Verrips, T.9
-
52
-
-
10744225632
-
Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1
-
10.1002/prot.20005, 14997552
-
Nuttall SD, Humbestone KS, Krishnan UV, Carmichael JA, Doughty L, Hattarki M, Coley AM, Casey JL, Anders RF, Foley M, Irving RA, Hudson PJ. Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1. Proteins 2004, 55:187-197. 10.1002/prot.20005, 14997552.
-
(2004)
Proteins
, vol.55
, pp. 187-197
-
-
Nuttall, S.D.1
Humbestone, K.S.2
Krishnan, U.V.3
Carmichael, J.A.4
Doughty, L.5
Hattarki, M.6
Coley, A.M.7
Casey, J.L.8
Anders, R.F.9
Foley, M.10
Irving, R.A.11
Hudson, P.J.12
-
53
-
-
35748949254
-
Structure of an IgNAR-AMA1 complex: targetig a conserved hydrophobic cleft broadens malarial strain recognition
-
10.1016/j.str.2007.09.011, 17997971
-
Henderson KA, Streltsov VA, Coley AM, Dolezal O, Hudson PJ, Batchelor AH, Gupta A, Bai T, Murphy VJ, Anders RF, Foley M, Nuttall SD. Structure of an IgNAR-AMA1 complex: targetig a conserved hydrophobic cleft broadens malarial strain recognition. Structure 2007, 15:1452-1466. 10.1016/j.str.2007.09.011, 17997971.
-
(2007)
Structure
, vol.15
, pp. 1452-1466
-
-
Henderson, K.A.1
Streltsov, V.A.2
Coley, A.M.3
Dolezal, O.4
Hudson, P.J.5
Batchelor, A.H.6
Gupta, A.7
Bai, T.8
Murphy, V.J.9
Anders, R.F.10
Foley, M.11
Nuttall, S.D.12
-
54
-
-
59749098914
-
Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis
-
10.1016/j.ijpara.2008.10.012, 19041315
-
Deckers N, Saerens D, Kanobana K, Conrath K, Victor B, Wernery U, Vercruysse J, Muyldermans S, Dorny P. Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis. Int J Parasitol 2009, 39:625-633. 10.1016/j.ijpara.2008.10.012, 19041315.
-
(2009)
Int J Parasitol
, vol.39
, pp. 625-633
-
-
Deckers, N.1
Saerens, D.2
Kanobana, K.3
Conrath, K.4
Victor, B.5
Wernery, U.6
Vercruysse, J.7
Muyldermans, S.8
Dorny, P.9
-
55
-
-
9144220168
-
Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies
-
Stijlemans B, Conrath K, Cortez-Retamozo V, Van Xong H, Wyns L, Senter P, Revets H, De Baetselier P, Muyldermans S, Magez S. Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. J Biol Chem 2004, 279:1256-1261.
-
(2004)
J Biol Chem
, vol.279
, pp. 1256-1261
-
-
Stijlemans, B.1
Conrath, K.2
Cortez-Retamozo, V.3
Van Xong, H.4
Wyns, L.5
Senter, P.6
Revets, H.7
De Baetselier, P.8
Muyldermans, S.9
Magez, S.10
-
56
-
-
33646545070
-
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor
-
10.1038/nm1395, 16604085
-
Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P. Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. Nat Med 2006, 12:580-584. 10.1038/nm1395, 16604085.
-
(2006)
Nat Med
, vol.12
, pp. 580-584
-
-
Baral, T.N.1
Magez, S.2
Stijlemans, B.3
Conrath, K.4
Vanhollebeke, B.5
Pays, E.6
Muyldermans, S.7
De Baetselier, P.8
-
57
-
-
36849056018
-
Parallel selection of multiple anti-infectome nanobodies without access to purified antigens
-
Saerens D, Stijlemans B, Baral TN, Nguyen Thi GT, Wernery U, Magez S, De Baetselier P, Muyldermans S, Conrath K. Parallel selection of multiple anti-infectome nanobodies without access to purified antigens. J Immunol Meth 2008, 329:138-150.
-
(2008)
J Immunol Meth
, vol.329
, pp. 138-150
-
-
Saerens, D.1
Stijlemans, B.2
Baral, T.N.3
Nguyen Thi, G.T.4
Wernery, U.5
Magez, S.6
De Baetselier, P.7
Muyldermans, S.8
Conrath, K.9
-
58
-
-
47749146847
-
Flow cytometry enumeration of parasitemia and hematologic changes in trypanosome-infected mice
-
10.1016/j.actatropica.2008.05.010, 18589393
-
Antoine-Moussiaux N, Saerens D, Desmecht D. Flow cytometry enumeration of parasitemia and hematologic changes in trypanosome-infected mice. Acta Trop 2008, 107:139-144. 10.1016/j.actatropica.2008.05.010, 18589393.
-
(2008)
Acta Trop
, vol.107
, pp. 139-144
-
-
Antoine-Moussiaux, N.1
Saerens, D.2
Desmecht, D.3
-
59
-
-
0035222608
-
The antiviral activity of antibodies in vitro and in vivo
-
Parren PV, Burton DR. The antiviral activity of antibodies in vitro and in vivo. Adv Immunol 2001, 77:195-262.
-
(2001)
Adv Immunol
, vol.77
, pp. 195-262
-
-
Parren, P.V.1
Burton, D.R.2
-
60
-
-
0344447084
-
Potent enzyme inhibitors derived from dromedary heavy-chain antibodies
-
10.1093/emboj/17.13.3512, 1170688, 9649422
-
Lauwereys M, Arbabi Ghahroudi M, Desmyter A, Kinne J, Hölzer W, De Genst E, Wyns L, Muyldermans S. Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. EMBO J 1998, 17:3512-3520. 10.1093/emboj/17.13.3512, 1170688, 9649422.
-
(1998)
EMBO J
, vol.17
, pp. 3512-3520
-
-
Lauwereys, M.1
Arbabi Ghahroudi, M.2
Desmyter, A.3
Kinne, J.4
Hölzer, W.5
De Genst, E.6
Wyns, L.7
Muyldermans, S.8
-
61
-
-
24144458917
-
Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins
-
10.1016/j.vaccine.2005.05.017, 15992972
-
Harmsen MM, Van Solt CB, Fijten HPD, Van Setten MC. Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins. Vaccine 2005, 23:4926-4934. 10.1016/j.vaccine.2005.05.017, 15992972.
-
(2005)
Vaccine
, vol.23
, pp. 4926-4934
-
-
Harmsen, M.M.1
Van Solt, C.B.2
Fijten, H.P.D.3
Van Setten, M.C.4
-
62
-
-
33846820458
-
Passive immunization of guinea-pigs with llama single-domain antibody fragments against foot-and-mouth disease
-
10.1016/j.vetmic.2006.10.029, 17127019
-
Harmsen MM, Van Solt CB, Fijten HPD, Van Keulen L, Rosalia RA, Weerdmeester K, Cornelissen AH, De Bruin MG, Eblé PL, Dekker A. Passive immunization of guinea-pigs with llama single-domain antibody fragments against foot-and-mouth disease. Vet Microbiol 2007, 120:193-206. 10.1016/j.vetmic.2006.10.029, 17127019.
-
(2007)
Vet Microbiol
, vol.120
, pp. 193-206
-
-
Harmsen, M.M.1
Van Solt, C.B.2
Fijten, H.P.D.3
Van Keulen, L.4
Rosalia, R.A.5
Weerdmeester, K.6
Cornelissen, A.H.7
De Bruin, M.G.8
Eblé, P.L.9
Dekker, A.10
-
63
-
-
70349680965
-
Enhancement of toxin-and virus-neutralizing capacity of single-domain antibody fragments by N-glcosylation
-
10.1007/s00253-009-2029-1, 2755796, 19455325
-
Harmsen MM, Van Solt CB, Fijten HPD. Enhancement of toxin-and virus-neutralizing capacity of single-domain antibody fragments by N-glcosylation. Appl Microbiol Biotechnol 2009, 84:1087-1094. 10.1007/s00253-009-2029-1, 2755796, 19455325.
-
(2009)
Appl Microbiol Biotechnol
, vol.84
, pp. 1087-1094
-
-
Harmsen, M.M.1
Van Solt, C.B.2
Fijten, H.P.D.3
-
64
-
-
38449097605
-
Rapid assembly of sensitive antigen-capture assays for Marburg virus, using in vitro selection of llama single-domain antibodies, at biosafety level 4
-
10.1086/520586, 17940952
-
Sherwood LJ, Osborn LE, Carrion R, Patterson JL, Hayhurst A. Rapid assembly of sensitive antigen-capture assays for Marburg virus, using in vitro selection of llama single-domain antibodies, at biosafety level 4. J Infect Dis 2007, 196:S213-S219. 10.1086/520586, 17940952.
-
(2007)
J Infect Dis
, vol.196
-
-
Sherwood, L.J.1
Osborn, L.E.2
Carrion, R.3
Patterson, J.L.4
Hayhurst, A.5
-
65
-
-
33747608138
-
Reduction of morbidity of rotavirus induced diarrhoe in mice by yeast produced monovalent llama-derived antibody fragment
-
10.1016/j.vaccine.2006.02.045, 16616802
-
van der Vaart JM, Pant N, Wolvers D, Bezemer S, Hermans PW, Bellamy K, Sarker SA, van der Logt CP, Svensson L, Verrips CT, Hammarström L, van Klinken BJ. Reduction of morbidity of rotavirus induced diarrhoe in mice by yeast produced monovalent llama-derived antibody fragment. Vaccine 2006, 24:4130-4137. 10.1016/j.vaccine.2006.02.045, 16616802.
-
(2006)
Vaccine
, vol.24
, pp. 4130-4137
-
-
van der Vaart, J.M.1
Pant, N.2
Wolvers, D.3
Bezemer, S.4
Hermans, P.W.5
Bellamy, K.6
Sarker, S.A.7
van der Logt, C.P.8
Svensson, L.9
Verrips, C.T.10
Hammarström, L.11
van Klinken, B.J.12
-
66
-
-
52649114833
-
Llama-derived single-chain antibody fragments directed to rotavirus VP6 protein possess broad neutralizing activity in vitro and confer protection against diarrhea in mice
-
10.1128/JVI.00436-08, 2546978, 18632867
-
Garaicoechea L, Olichon A, Marcoppido G, Wigdorovitz A, Mozgovoj M, Saif L, Surrey T, Parreño V. Llama-derived single-chain antibody fragments directed to rotavirus VP6 protein possess broad neutralizing activity in vitro and confer protection against diarrhea in mice. J Virol 2008, 82:9753-9764. 10.1128/JVI.00436-08, 2546978, 18632867.
-
(2008)
J Virol
, vol.82
, pp. 9753-9764
-
-
Garaicoechea, L.1
Olichon, A.2
Marcoppido, G.3
Wigdorovitz, A.4
Mozgovoj, M.5
Saif, L.6
Surrey, T.7
Parreño, V.8
-
67
-
-
33845225906
-
Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea
-
10.1086/508747, 17083044
-
Pant N, Hultberg A, Zhao Y, Svensson L, Pan-Hammarström Q, Johansen K, Pouwels PH, Ruggeri FM, Hermans P, Frenken L, Boren T, Marcotte H, Hammarström L. Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea. J Infect Dis 2006, 194:1580-1588. 10.1086/508747, 17083044.
-
(2006)
J Infect Dis
, vol.194
, pp. 1580-1588
-
-
Pant, N.1
Hultberg, A.2
Zhao, Y.3
Svensson, L.4
Pan-Hammarström, Q.5
Johansen, K.6
Pouwels, P.H.7
Ruggeri, F.M.8
Hermans, P.9
Frenken, L.10
Boren, T.11
Marcotte, H.12
Hammarström, L.13
-
68
-
-
79953208274
-
Integrative expression system for delivery of antibody fragments by lactobacilli
-
10.1128/AEM.02690-10, 21257814
-
Martin MC, Pant N, Ladero V, Günaydin G, Andersen KK, Alvarez B, Martínez N, Alvarez MA, Hammarström L, Marcotte H. Integrative expression system for delivery of antibody fragments by lactobacilli. Appl Environ Microbiol 2011, 77:2174-2179. 10.1128/AEM.02690-10, 21257814.
-
(2011)
Appl Environ Microbiol
, vol.77
, pp. 2174-2179
-
-
Martin, M.C.1
Pant, N.2
Ladero, V.3
Günaydin, G.4
Andersen, K.K.5
Alvarez, B.6
Martínez, N.7
Alvarez, M.A.8
Hammarström, L.9
Marcotte, H.10
-
69
-
-
77954957478
-
In vitro antiviral activity of single domain antibody fragments against poliovirus
-
10.1016/j.antiviral.2010.05.012, 20566349
-
Thys B, Schotte L, Muyldermans S, Wernery U, Hassanzadeh-Ghassabeh G, Rombaut B. In vitro antiviral activity of single domain antibody fragments against poliovirus. Antiviral Res 2010, 87:257-264. 10.1016/j.antiviral.2010.05.012, 20566349.
-
(2010)
Antiviral Res
, vol.87
, pp. 257-264
-
-
Thys, B.1
Schotte, L.2
Muyldermans, S.3
Wernery, U.4
Hassanzadeh-Ghassabeh, G.5
Rombaut, B.6
-
70
-
-
79954580247
-
A simple quantitative affinity capturing assay of poliovirus antigens and subviral particles by single-domain antibodies using magnetic beads
-
Thys B, Saerens D, Schotte L, De Bleeser G, Muyldermans S, Hassanzadeh-Ghassabeh G, Rombaut B. A simple quantitative affinity capturing assay of poliovirus antigens and subviral particles by single-domain antibodies using magnetic beads. J Virol Meth 2011, 173:300-305.
-
(2011)
J Virol Meth
, vol.173
, pp. 300-305
-
-
Thys, B.1
Saerens, D.2
Schotte, L.3
De Bleeser, G.4
Muyldermans, S.5
Hassanzadeh-Ghassabeh, G.6
Rombaut, B.7
-
71
-
-
33845516882
-
Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library
-
10.1021/ac0610053, 2528076, 17165813
-
Goldman ER, Anderson GP, Liu JL, Delehanty JB, Sherwood LJ, Osborn LE, Cummins LB, Hayhurst A. Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library. Anal Chem 2006, 78:8245-8255. 10.1021/ac0610053, 2528076, 17165813.
-
(2006)
Anal Chem
, vol.78
, pp. 8245-8255
-
-
Goldman, E.R.1
Anderson, G.P.2
Liu, J.L.3
Delehanty, J.B.4
Sherwood, L.J.5
Osborn, L.E.6
Cummins, L.B.7
Hayhurst, A.8
-
72
-
-
58949094406
-
Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice
-
Serruys B, Van Houtte F, Verbrugghe P, Leroux-Roels G, Vanlandschoot P. Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice. Hepathol 2009, 49:39-49.
-
(2009)
Hepathol
, vol.49
, pp. 39-49
-
-
Serruys, B.1
Van Houtte, F.2
Verbrugghe, P.3
Leroux-Roels, G.4
Vanlandschoot, P.5
-
73
-
-
76849094865
-
Production, characterization and in vitro testing of HBcAg-specific VHH intrabodies
-
10.1099/vir.0.016063-0, 19889923
-
Serruys B, Van Houtte F, Farhoudi-Moghadam A, Leroux-Roels G, Vanlandschoot P. Production, characterization and in vitro testing of HBcAg-specific VHH intrabodies. J Gen Virol 2010, 91:643-652. 10.1099/vir.0.016063-0, 19889923.
-
(2010)
J Gen Virol
, vol.91
, pp. 643-652
-
-
Serruys, B.1
Van Houtte, F.2
Farhoudi-Moghadam, A.3
Leroux-Roels, G.4
Vanlandschoot, P.5
-
74
-
-
79551685528
-
Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody
-
Walsh R, Nuttall S, Revill P, Colledge D, Cabuang L, Soppe S, Dolezal O, Griffiths K, Bartholomeusz A, Locarnini S. Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody. Virol 2011, 411:132-141.
-
(2011)
Virol
, vol.411
, pp. 132-141
-
-
Walsh, R.1
Nuttall, S.2
Revill, P.3
Colledge, D.4
Cabuang, L.5
Soppe, S.6
Dolezal, O.7
Griffiths, K.8
Bartholomeusz, A.9
Locarnini, S.10
-
75
-
-
77954356408
-
An intrabody based on a llama single-domain antibody targeting the N-terminal α-helical multimerization domain of HIV-1 Rev prevents viral production
-
10.1074/jbc.M110.112490, 20406803
-
Vercruysse T, Pardon E, Vanstreels E, Steyaert J, Daelemans D. An intrabody based on a llama single-domain antibody targeting the N-terminal α-helical multimerization domain of HIV-1 Rev prevents viral production. J Biol Chem 2010, 285:21768-21780. 10.1074/jbc.M110.112490, 20406803.
-
(2010)
J Biol Chem
, vol.285
, pp. 21768-21780
-
-
Vercruysse, T.1
Pardon, E.2
Vanstreels, E.3
Steyaert, J.4
Daelemans, D.5
-
76
-
-
78650573881
-
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
-
10.1073/pnas.1012865107, 2996674, 21059953
-
Jähnichen S, Blanchetot C, Maussang D, Gonzalez-Pajuelo M, Chow KY, Bosch L, De Vrieze S, Serruys B, Ulrichts H, Vandevelde W, Saunders M, De Haard HJ, Schols D, Leurs R, Vanlandschoot P, Verrips T, Smit MJ. CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells. Proc Natl Acad Sci USA 2010, 107:20565-20570. 10.1073/pnas.1012865107, 2996674, 21059953.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20565-20570
-
-
Jähnichen, S.1
Blanchetot, C.2
Maussang, D.3
Gonzalez-Pajuelo, M.4
Chow, K.Y.5
Bosch, L.6
De Vrieze, S.7
Serruys, B.8
Ulrichts, H.9
Vandevelde, W.10
Saunders, M.11
De Haard, H.J.12
Schols, D.13
Leurs, R.14
Vanlandschoot, P.15
Verrips, T.16
Smit, M.J.17
-
77
-
-
57349165849
-
Llama antibody fragments with cross-subtype human immuodeficency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120
-
10.1128/JVI.01379-08, 2593325, 18842738
-
Forsman A, Beirnaert E, Aasa-Chapman MMI, Hoorelbeke B, Hijazi K, Koh W, Tack V, Szynol A, Kelly C, McKnight A, Verrips T, de Haard H, Weiss RA. Llama antibody fragments with cross-subtype human immuodeficency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120. J Virol 2008, 82:12069-12081. 10.1128/JVI.01379-08, 2593325, 18842738.
-
(2008)
J Virol
, vol.82
, pp. 12069-12081
-
-
Forsman, A.1
Beirnaert, E.2
Aasa-Chapman, M.M.I.3
Hoorelbeke, B.4
Hijazi, K.5
Koh, W.6
Tack, V.7
Szynol, A.8
Kelly, C.9
McKnight, A.10
Verrips, T.11
de Haard, H.12
Weiss, R.A.13
-
78
-
-
77953513983
-
Generation of a family-specific phage library of llama single chain antibody fragments that neutralize HIV-1
-
10.1074/jbc.M110.116699, 2885190, 20400507
-
Koh WW, Steffensen S, Gonzalez-Pajuelo M, Hoorelbeke B, Gorlani A, Szynol A, Forsman A, Aasa-Chapman MM, de Haard H, Verrips T, Weiss RA. Generation of a family-specific phage library of llama single chain antibody fragments that neutralize HIV-1. J Biol Chem 2010, 285:19116-19124. 10.1074/jbc.M110.116699, 2885190, 20400507.
-
(2010)
J Biol Chem
, vol.285
, pp. 19116-19124
-
-
Koh, W.W.1
Steffensen, S.2
Gonzalez-Pajuelo, M.3
Hoorelbeke, B.4
Gorlani, A.5
Szynol, A.6
Forsman, A.7
Aasa-Chapman, M.M.8
de Haard, H.9
Verrips, T.10
Weiss, R.A.11
-
79
-
-
77953508965
-
Crystal structure of the neutralizing llama VHH D7 and its mode of HIV-1 gp120 interaction
-
Hinz A, Hulsik DL, Forsman A, Koh WW, Belrhali H, Gorlani A, de Haard H, Weiss RA, Verrips T, Weissenhorn W. Crystal structure of the neutralizing llama VHH D7 and its mode of HIV-1 gp120 interaction. PLoSOne 2010, 5:e10482.
-
(2010)
PLoSOne
, vol.5
-
-
Hinz, A.1
Hulsik, D.L.2
Forsman, A.3
Koh, W.W.4
Belrhali, H.5
Gorlani, A.6
de Haard, H.7
Weiss, R.A.8
Verrips, T.9
Weissenhorn, W.10
-
80
-
-
78649677843
-
Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain
-
10.1074/jbc.M110.149476, 20817723
-
Möller A, Pion E, Narayan V, Ball KL. Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain. J Biol Chem 2010, 285:38348-38361. 10.1074/jbc.M110.149476, 20817723.
-
(2010)
J Biol Chem
, vol.285
, pp. 38348-38361
-
-
Möller, A.1
Pion, E.2
Narayan, V.3
Ball, K.L.4
-
81
-
-
34848877452
-
Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV-1 virion infectivity factor
-
10.1016/j.bios.2007.04.022, 17574408
-
Ferreira GN, Encarnacao JM, Rosa L, Rodrigues R, Beyner R, Barrento S, Pedro L, Aires da Silva F, Gonçalves J. Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV-1 virion infectivity factor. Biosens Bioelectron 2007, 23:384-392. 10.1016/j.bios.2007.04.022, 17574408.
-
(2007)
Biosens Bioelectron
, vol.23
, pp. 384-392
-
-
Ferreira, G.N.1
Encarnacao, J.M.2
Rosa, L.3
Rodrigues, R.4
Beyner, R.5
Barrento, S.6
Pedro, L.7
Aires da Silva, F.8
Gonçalves, J.9
-
82
-
-
79953318592
-
Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection
-
10.1093/infdis/jiq168, 21450996
-
Ibañez LI, De Filette M, Hultberg A, Verrips T, Temperton N, Weiss RA, Vandevelde W, Schepens B, Vanlandschoot P, Saelens X. Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection. J Infect Dis 2011, 203:1063-1072. 10.1093/infdis/jiq168, 21450996.
-
(2011)
J Infect Dis
, vol.203
, pp. 1063-1072
-
-
Ibañez, L.I.1
De Filette, M.2
Hultberg, A.3
Verrips, T.4
Temperton, N.5
Weiss, R.A.6
Vandevelde, W.7
Schepens, B.8
Vanlandschoot, P.9
Saelens, X.10
-
83
-
-
79953654632
-
Llama-derived single-domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules
-
10.1371/journal.pone.0017665, 3069976, 21483777
-
Hultberg A, Temperton N, Rosseels V, Koenders M, Gonzalez-Pajuelo M, Schepens B, Ibañez LI, Vanlandschoot P, Schillemans J, Saunders M, Weiss RA, Saelens X, Melero JA, Verrips CT, Van Gucht S, de Haard HJ. Llama-derived single-domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. PLoS One 2011, 6:e17665. 10.1371/journal.pone.0017665, 3069976, 21483777.
-
(2011)
PLoS One
, vol.6
-
-
Hultberg, A.1
Temperton, N.2
Rosseels, V.3
Koenders, M.4
Gonzalez-Pajuelo, M.5
Schepens, B.6
Ibañez, L.I.7
Vanlandschoot, P.8
Schillemans, J.9
Saunders, M.10
Weiss, R.A.11
Saelens, X.12
Melero, J.A.13
Verrips, C.T.14
Van Gucht, S.15
de Haard, H.J.16
-
84
-
-
33846979756
-
Heating represents a rapid purification method for recovering correctly folded thermo tolerant VH and VHH domains
-
10.1186/1472-6750-7-7, 1790891, 17257422
-
Olichon A, Schweizer D, Muyldermans S, de Marco A. Heating represents a rapid purification method for recovering correctly folded thermo tolerant VH and VHH domains. BMC Biotechnol 2007, 7:7. 10.1186/1472-6750-7-7, 1790891, 17257422.
-
(2007)
BMC Biotechnol
, vol.7
, pp. 7
-
-
Olichon, A.1
Schweizer, D.2
Muyldermans, S.3
de Marco, A.4
-
85
-
-
77950022629
-
A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic α-exosite binding region
-
10.1016/j.jmb.2010.01.070, 2903050, 20138889
-
Dong J, Thompson AA, Fan Y, Lou J, Conrad F, Ho M, Pires-Alves M, Wilson BA, Stevens RC, Marks JD. A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic α-exosite binding region. J Mol Biol 2010, 397:1106-1118. 10.1016/j.jmb.2010.01.070, 2903050, 20138889.
-
(2010)
J Mol Biol
, vol.397
, pp. 1106-1118
-
-
Dong, J.1
Thompson, A.A.2
Fan, Y.3
Lou, J.4
Conrad, F.5
Ho, M.6
Pires-Alves, M.7
Wilson, B.A.8
Stevens, R.C.9
Marks, J.D.10
-
86
-
-
74949120905
-
Single domain antibodies are specially suited for quantitative determination of gliadins under denaturing conditions
-
10.1021/jf902973c, 20039674
-
Doňa V, Urrutia M, Bayardo M, Alzogaray V, Goldbaum FA, Chirdo FG. Single domain antibodies are specially suited for quantitative determination of gliadins under denaturing conditions. J Agric Food Chem 2010, 58:918-926. 10.1021/jf902973c, 20039674.
-
(2010)
J Agric Food Chem
, vol.58
, pp. 918-926
-
-
Doňa, V.1
Urrutia, M.2
Bayardo, M.3
Alzogaray, V.4
Goldbaum, F.A.5
Chirdo, F.G.6
-
87
-
-
38649143625
-
Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library
-
10.1186/1472-6750-7-78, 2213646, 18021450
-
Liu JL, Anderson GP, Goldman ER. Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library. BMC Biotechnol 2007, 7:78. 10.1186/1472-6750-7-78, 2213646, 18021450.
-
(2007)
BMC Biotechnol
, vol.7
, pp. 78
-
-
Liu, J.L.1
Anderson, G.P.2
Goldman, E.R.3
-
88
-
-
39049132442
-
Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark library
-
Liu JL, Anderson GP, Delehanty JB, Baumann R, Hayhurst A, Goldman ER. Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark library. Mol Immunol 2007, 44:177-1783.
-
(2007)
Mol Immunol
, vol.44
, pp. 177-1783
-
-
Liu, J.L.1
Anderson, G.P.2
Delehanty, J.B.3
Baumann, R.4
Hayhurst, A.5
Goldman, E.R.6
-
89
-
-
71749096566
-
Amplification of immunoassays using phage-displayed single domain antibodies
-
Goldman ER, Anderson GP, Bernstein RD, Swain MD. Amplification of immunoassays using phage-displayed single domain antibodies. J Immunol Meth 2010, 352:182-185.
-
(2010)
J Immunol Meth
, vol.352
, pp. 182-185
-
-
Goldman, E.R.1
Anderson, G.P.2
Bernstein, R.D.3
Swain, M.D.4
-
90
-
-
67649997689
-
Multiplexed detection of bacteria and toxins using a microflow cytometer
-
10.1021/ac9005827, 2747802, 19496600
-
Kim JS, Anderson GP, Erickson JS, Golden JP, Nasir M, Ligler FS. Multiplexed detection of bacteria and toxins using a microflow cytometer. Anal Chem 2009, 81:5426-5432. 10.1021/ac9005827, 2747802, 19496600.
-
(2009)
Anal Chem
, vol.81
, pp. 5426-5432
-
-
Kim, J.S.1
Anderson, G.P.2
Erickson, J.S.3
Golden, J.P.4
Nasir, M.5
Ligler, F.S.6
-
91
-
-
77649184818
-
Sub-attomolar detection of cholera toxin using a label-free capacitive immunosensor
-
10.1016/j.bios.2010.01.020, 20167466
-
Loyprasert S, Hedström M, Thavarungkul P, Kanatharana P, Mattiasson B. Sub-attomolar detection of cholera toxin using a label-free capacitive immunosensor. Biosens Bioelectron 2010, 25:1977-1983. 10.1016/j.bios.2010.01.020, 20167466.
-
(2010)
Biosens Bioelectron
, vol.25
, pp. 1977-1983
-
-
Loyprasert, S.1
Hedström, M.2
Thavarungkul, P.3
Kanatharana, P.4
Mattiasson, B.5
-
92
-
-
77649180335
-
Single domain antibody templated nanoparticle resistors for sensing
-
10.1016/j.bios.2010.01.004, 20117926
-
Slocik JM, Kim SN, Auvil T, Goldman ER, Liu J, Naik RR. Single domain antibody templated nanoparticle resistors for sensing. Biosens Bioelectron 2010, 25:1908-1913. 10.1016/j.bios.2010.01.004, 20117926.
-
(2010)
Biosens Bioelectron
, vol.25
, pp. 1908-1913
-
-
Slocik, J.M.1
Kim, S.N.2
Auvil, T.3
Goldman, E.R.4
Liu, J.5
Naik, R.R.6
-
93
-
-
79551645748
-
Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium
-
10.1096/fj.10-162958, 20940265
-
Alzogaray V, Danquah W, Aguirre A, Urrutia M, Berguer P, Garcia Vescovi E, Haag F, Koch-Nolte F, Goldbaum FA. Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium. FASEB J 2011, 25:526-234. 10.1096/fj.10-162958, 20940265.
-
(2011)
FASEB J
, vol.25
, pp. 526-1234
-
-
Alzogaray, V.1
Danquah, W.2
Aguirre, A.3
Urrutia, M.4
Berguer, P.5
Garcia Vescovi, E.6
Haag, F.7
Koch-Nolte, F.8
Goldbaum, F.A.9
-
94
-
-
48049096810
-
VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'
-
10.1016/j.molimm.2008.04.011, 18614235
-
Hmila I, Ben-Abderrazek Ben-Abdallah R, Saerens D, Benlasfar Z, Conrath K, Ayeb ME, Muyldermans S, Bouhaouala-Zahar B. VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'. Mol Immunol 2008, 45:3847-3856. 10.1016/j.molimm.2008.04.011, 18614235.
-
(2008)
Mol Immunol
, vol.45
, pp. 3847-3856
-
-
Hmila, I.1
Ben-Abderrazek Ben-Abdallah, R.2
Saerens, D.3
Benlasfar, Z.4
Conrath, K.5
Ayeb, M.E.6
Muyldermans, S.7
Bouhaouala-Zahar, B.8
-
95
-
-
70450178687
-
Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom
-
10.1042/BJ20090697, 19732033
-
Ben-Abderrazek Ben-Abdallah R, Hmila I, Vincke C, Benlasfar Z, Pellis M, Dabbek H, Saerens D, El Ayeb M, Muyldermans S, Bouhaouala-Zahar B. Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom. Biochem J 2009, 424:263-272. 10.1042/BJ20090697, 19732033.
-
(2009)
Biochem J
, vol.424
, pp. 263-272
-
-
Ben-Abderrazek Ben-Abdallah, R.1
Hmila, I.2
Vincke, C.3
Benlasfar, Z.4
Pellis, M.5
Dabbek, H.6
Saerens, D.7
El Ayeb, M.8
Muyldermans, S.9
Bouhaouala-Zahar, B.10
-
96
-
-
77956631367
-
A bispecific nanobody to provide full protection against lethal scorpion envenoming
-
10.1096/fj.09-148213, 20410443
-
Hmila I, Saerens D, Ben-Abderrazek Ben-Abdallah R, Vincke C, Abidi N, Benlasfar Z, Govaert J, El Ayeb M, Bouhaouala-Zahar B, Muyldermans S. A bispecific nanobody to provide full protection against lethal scorpion envenoming. FASEB J 2010, 24:3479-3489. 10.1096/fj.09-148213, 20410443.
-
(2010)
FASEB J
, vol.24
, pp. 3479-3489
-
-
Hmila, I.1
Saerens, D.2
Ben-Abderrazek Ben-Abdallah, R.3
Vincke, C.4
Abidi, N.5
Benlasfar, Z.6
Govaert, J.7
El Ayeb, M.8
Bouhaouala-Zahar, B.9
Muyldermans, S.10
-
97
-
-
0035831483
-
Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
-
10.1074/jbc.M007734200, 11053416
-
Conrath EK, Lauwereys M, Wyns L, Muyldermans S. Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs. J Biol Chem 2001, 276:7346-7350. 10.1074/jbc.M007734200, 11053416.
-
(2001)
J Biol Chem
, vol.276
, pp. 7346-7350
-
-
Conrath, E.K.1
Lauwereys, M.2
Wyns, L.3
Muyldermans, S.4
-
98
-
-
0344255688
-
Pentamerization of single-domain antibodies from phage libraries: a novel strategy for the rapid generation of high-avidity antibody
-
10.1016/j.jmb.2003.09.034, 14659739
-
Zhang J, Tanha J, Hirama T, Khieu NH, To R, Tong-Sevinc H, Stone E, Brisson JR, MacKenzie CR. Pentamerization of single-domain antibodies from phage libraries: a novel strategy for the rapid generation of high-avidity antibody. J Mol Biol 2004, 335:49-56. 10.1016/j.jmb.2003.09.034, 14659739.
-
(2004)
J Mol Biol
, vol.335
, pp. 49-56
-
-
Zhang, J.1
Tanha, J.2
Hirama, T.3
Khieu, N.H.4
To, R.5
Tong-Sevinc, H.6
Stone, E.7
Brisson, J.R.8
MacKenzie, C.R.9
-
99
-
-
33845886914
-
The assembly of single domain antibodies into bispecific decavalent molecules
-
Stone E, Hirama T, Tanha J, Tong-Sevinc H, Li S, MacKenzie CR, Zhang J. The assembly of single domain antibodies into bispecific decavalent molecules. J Immunol Meth 2007, 318:88-94.
-
(2007)
J Immunol Meth
, vol.318
, pp. 88-94
-
-
Stone, E.1
Hirama, T.2
Tanha, J.3
Tong-Sevinc, H.4
Li, S.5
MacKenzie, C.R.6
Zhang, J.7
-
100
-
-
33846238190
-
A novel pentamer versus pentamer approach to generating neutralizers of verotoxin 1
-
10.1016/j.molimm.2006.10.020, 17134756
-
Stone E, Hirama T, Chen W, Soltyk AL, Brunton J, MacKenzie CR, Zhang J. A novel pentamer versus pentamer approach to generating neutralizers of verotoxin 1. Mol Immunol 2007, 44:2487-2491. 10.1016/j.molimm.2006.10.020, 17134756.
-
(2007)
Mol Immunol
, vol.44
, pp. 2487-2491
-
-
Stone, E.1
Hirama, T.2
Chen, W.3
Soltyk, A.L.4
Brunton, J.5
MacKenzie, C.R.6
Zhang, J.7
-
101
-
-
33947306907
-
Isolation, characterization and pentamerization of alpha-cobrotoxin specific single-domain antibodies from a naïve phage display library: preliminary findings for antivenom development
-
Stewart CS, MacKenzie CR, Hall JC. Isolation, characterization and pentamerization of alpha-cobrotoxin specific single-domain antibodies from a naïve phage display library: preliminary findings for antivenom development. Toxicon 49:699-709.
-
Toxicon
, vol.49
, pp. 699-709
-
-
Stewart, C.S.1
MacKenzie, C.R.2
Hall, J.C.3
-
102
-
-
79953206941
-
Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell-receptor binding domain
-
10.1074/jbc.M110.198754, 21216961
-
Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, Mackenzie R, Tanha J. Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell-receptor binding domain. J Biol Chem 2011, 286:8961-8976. 10.1074/jbc.M110.198754, 21216961.
-
(2011)
J Biol Chem
, vol.286
, pp. 8961-8976
-
-
Hussack, G.1
Arbabi-Ghahroudi, M.2
van Faassen, H.3
Songer, J.G.4
Ng, K.K.5
Mackenzie, R.6
Tanha, J.7
-
103
-
-
69249133338
-
Specific immuno capturing of the staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma
-
10.1002/bit.22365, 19475676
-
Adams H, Brummelhuis W, Maassen B, van Egmond N, El Khattabi M, Detmers F. Specific immuno capturing of the staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma. Biotechnol Bioeng 2009, 104:143-151. 10.1002/bit.22365, 19475676.
-
(2009)
Biotechnol Bioeng
, vol.104
, pp. 143-151
-
-
Adams, H.1
Brummelhuis, W.2
Maassen, B.3
van Egmond, N.4
El Khattabi, M.5
Detmers, F.6
-
104
-
-
77954998434
-
Llama heavy-chain antibody fragments efficiently remove toxic shock syndrome toxin 1 from plasma in vitro but not in experimental porcine septic shock
-
10.1097/SHK.0b013e3181cdc556, 20016410
-
Brummelhuis W, Joles JA, Stam JC, Adams H, Goldschmeding R, Detmers FJ, El Khattabi M, Maassen BT, Verrips CT, Braam B. Llama heavy-chain antibody fragments efficiently remove toxic shock syndrome toxin 1 from plasma in vitro but not in experimental porcine septic shock. Shock 2010, 34:125-132. 10.1097/SHK.0b013e3181cdc556, 20016410.
-
(2010)
Shock
, vol.34
, pp. 125-132
-
-
Brummelhuis, W.1
Joles, J.A.2
Stam, J.C.3
Adams, H.4
Goldschmeding, R.5
Detmers, F.J.6
El Khattabi, M.7
Maassen, B.T.8
Verrips, C.T.9
Braam, B.10
-
105
-
-
79954589794
-
An altered camelid-like single domain anti-idiotypc antibody fragment of HM-1 killer toxin: acts as an effective antifungal agent
-
10.1007/s00253-011-3123-8, 21305279
-
Kabir ME, Krishnaswamy S, Miyamoto M, Furuichi Y, Komiyama T. An altered camelid-like single domain anti-idiotypc antibody fragment of HM-1 killer toxin: acts as an effective antifungal agent. Appl Microbiol Biotechnol 2011, 90:553-564. 10.1007/s00253-011-3123-8, 21305279.
-
(2011)
Appl Microbiol Biotechnol
, vol.90
, pp. 553-564
-
-
Kabir, M.E.1
Krishnaswamy, S.2
Miyamoto, M.3
Furuichi, Y.4
Komiyama, T.5
-
106
-
-
37349125965
-
Multiplexed fluid array screening of phage displayed anti-ricin single domain antibodies for rapid assessment of specificity
-
10.2144/000112600, 18251258
-
Anderson GP, Matney R, Liu JL, Hayhurst A, Goldman ER. Multiplexed fluid array screening of phage displayed anti-ricin single domain antibodies for rapid assessment of specificity. Biotechniques 2007, 43:806-811. 10.2144/000112600, 18251258.
-
(2007)
Biotechniques
, vol.43
, pp. 806-811
-
-
Anderson, G.P.1
Matney, R.2
Liu, J.L.3
Hayhurst, A.4
Goldman, E.R.5
-
107
-
-
58149129878
-
Development of antiricin single domain antibodies toward detection and therapeutic reagents
-
10.1021/ac8019398, 19072267
-
Anderson GP, Liu JL, Hale ML, Bernstein RD, Moore M, Swain MD, Goldman ER. Development of antiricin single domain antibodies toward detection and therapeutic reagents. Anal Chem 2008, 80:9604-9611. 10.1021/ac8019398, 19072267.
-
(2008)
Anal Chem
, vol.80
, pp. 9604-9611
-
-
Anderson, G.P.1
Liu, J.L.2
Hale, M.L.3
Bernstein, R.D.4
Moore, M.5
Swain, M.D.6
Goldman, E.R.7
-
108
-
-
77956260971
-
Binding kinetics of antiricin single domain antibodies and improved detection using a B chain specific binder
-
10.1021/ac100961x, 20687583
-
Anderson GP, Bernstein RD, Swain MD, Zabetakis D, Goldman ER. Binding kinetics of antiricin single domain antibodies and improved detection using a B chain specific binder. Anal Chem 2010, 82:7202-7207. 10.1021/ac100961x, 20687583.
-
(2010)
Anal Chem
, vol.82
, pp. 7202-7207
-
-
Anderson, G.P.1
Bernstein, R.D.2
Swain, M.D.3
Zabetakis, D.4
Goldman, E.R.5
-
109
-
-
56449104900
-
Thermostable llama single domain antibodies for detection of botulinum A neurotoxin complex
-
10.1021/ac8014774, 2829253, 18947189
-
Goldman ER, Anderson GP, Conway J, Sherwood LJ, Fech M, Vo BH, Liu JL, Hayhurst A. Thermostable llama single domain antibodies for detection of botulinum A neurotoxin complex. Anal Chem 2008, 80:8583-8591. 10.1021/ac8014774, 2829253, 18947189.
-
(2008)
Anal Chem
, vol.80
, pp. 8583-8591
-
-
Goldman, E.R.1
Anderson, G.P.2
Conway, J.3
Sherwood, L.J.4
Fech, M.5
Vo, B.H.6
Liu, J.L.7
Hayhurst, A.8
-
110
-
-
77749320825
-
Llama single domain antibodies specific for the 7 botulinum neurotoxin serotypes as heptaplex immunoreagents
-
Conway JO, Sherwood LJ, Collazo MT, Garza JA, Hayhurst A. Llama single domain antibodies specific for the 7 botulinum neurotoxin serotypes as heptaplex immunoreagents. PLoSOne 2010, 5:e8818.
-
(2010)
PLoSOne
, vol.5
-
-
Conway, J.O.1
Sherwood, L.J.2
Collazo, M.T.3
Garza, J.A.4
Hayhurst, A.5
-
111
-
-
77955980966
-
Llama-derived single-domain antibodies for the detection of botulinum A neurotoxin
-
10.1007/s00216-010-3905-3, 20582697
-
Swain MD, Anderson GP, Zabetakis D, Bernstein RD, Liu JL, Sherwood LJ, Hayhurst A, Goldman ER. Llama-derived single-domain antibodies for the detection of botulinum A neurotoxin. Anal Bioanal Chem 2010, 398:339-348. 10.1007/s00216-010-3905-3, 20582697.
-
(2010)
Anal Bioanal Chem
, vol.398
, pp. 339-348
-
-
Swain, M.D.1
Anderson, G.P.2
Zabetakis, D.3
Bernstein, R.D.4
Liu, J.L.5
Sherwood, L.J.6
Hayhurst, A.7
Goldman, E.R.8
-
112
-
-
77956059355
-
Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases
-
10.1016/j.toxicon.2010.07.003, 20637220
-
Tremblay JM, Kuo C-L, Abeijon C, Sepulveda J, Oyler G, Hu X, Jin MM, Shoemaker CB. Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases. Toxicon 2010, 56:990-998. 10.1016/j.toxicon.2010.07.003, 20637220.
-
(2010)
Toxicon
, vol.56
, pp. 990-998
-
-
Tremblay, J.M.1
Kuo, C.-L.2
Abeijon, C.3
Sepulveda, J.4
Oyler, G.5
Hu, X.6
Jin, M.M.7
Shoemaker, C.B.8
-
113
-
-
0142185343
-
Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library
-
Yau KYF, Groves MAT, Li S, Sheedy C, Lee H, Tanha J, MacKenzie CR, Jermutus L, Hall JC. Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library. J Immunol Meth 2003, 281:161-175.
-
(2003)
J Immunol Meth
, vol.281
, pp. 161-175
-
-
Yau, K.Y.F.1
Groves, M.A.T.2
Li, S.3
Sheedy, C.4
Lee, H.5
Tanha, J.6
MacKenzie, C.R.7
Jermutus, L.8
Hall, J.C.9
-
114
-
-
33744938139
-
Selection, characterization, and CDR shuffling of naïve llama single-domain antibodies selected against auxin and their cross reactivity with auxinic herbicides from four chemical families
-
10.1021/jf060219i, 19127743
-
Sheedy C, Yau KY, Hirama T, MacKenzie CR, Hall JC. Selection, characterization, and CDR shuffling of naïve llama single-domain antibodies selected against auxin and their cross reactivity with auxinic herbicides from four chemical families. J Agric Food Chem 2006, 54:3668-3678. 10.1021/jf060219i, 19127743.
-
(2006)
J Agric Food Chem
, vol.54
, pp. 3668-3678
-
-
Sheedy, C.1
Yau, K.Y.2
Hirama, T.3
MacKenzie, C.R.4
Hall, J.C.5
-
115
-
-
33745686158
-
Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment
-
10.1021/ac058044j, 16808459
-
Ladenson RC, Crimmins DL, Landt Y, Ladenson JH. Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment. Anal Chem 2006, 78:4501-4508. 10.1021/ac058044j, 16808459.
-
(2006)
Anal Chem
, vol.78
, pp. 4501-4508
-
-
Ladenson, R.C.1
Crimmins, D.L.2
Landt, Y.3
Ladenson, J.H.4
-
116
-
-
33751319200
-
Generation of llama single-domain antibodies against methotrexate, a prototypcal hapten
-
10.1016/j.molimm.2006.08.007, 17011035
-
Alvarez-Rueda N, Behar G, Ferré V, Pugniere M, Roquet F, Gastinel L, Jacquot C, Aubry J, Baty D, Barbet J, Birklé S. Generation of llama single-domain antibodies against methotrexate, a prototypcal hapten. Mol Immunol 2007, 44:1680-1690. 10.1016/j.molimm.2006.08.007, 17011035.
-
(2007)
Mol Immunol
, vol.44
, pp. 1680-1690
-
-
Alvarez-Rueda, N.1
Behar, G.2
Ferré, V.3
Pugniere, M.4
Roquet, F.5
Gastinel, L.6
Jacquot, C.7
Aubry, J.8
Baty, D.9
Barbet, J.10
Birklé, S.11
-
117
-
-
48049099663
-
Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol
-
10.1016/j.molimm.2008.06.005, 18632156
-
Doyle PJ, Arbabi-Ghahroudi M, Gaudette N, Furzer G, Savard ME, Gleddie S. Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol. Mol Immunol 2008, 45:3703-3713. 10.1016/j.molimm.2008.06.005, 18632156.
-
(2008)
Mol Immunol
, vol.45
, pp. 3703-3713
-
-
Doyle, P.J.1
Arbabi-Ghahroudi, M.2
Gaudette, N.3
Furzer, G.4
Savard, M.E.5
Gleddie, S.6
-
118
-
-
53049108890
-
TNT detection using llama antibodies and a two-step competitive fluid array immunoassay
-
Anderson GP, Goldman ER. TNT detection using llama antibodies and a two-step competitive fluid array immunoassay. J Immunol Meth 2008, 339:47-54.
-
(2008)
J Immunol Meth
, vol.339
, pp. 47-54
-
-
Anderson, G.P.1
Goldman, E.R.2
-
119
-
-
71749095394
-
Intracellular expression of a single domain antibody reduces cytotoxicity of 15-acetyldeoxynivalenol in yeast
-
10.1074/jbc.M109.045047, 2787364, 19783651
-
Doyle PJ, Saeed H, Hermans A, Gleddie SC, Hussack G, Arbabi-Ghahroudi M, Seguin C, Savard ME, Mackenzie CR, Hall JC. Intracellular expression of a single domain antibody reduces cytotoxicity of 15-acetyldeoxynivalenol in yeast. J Biol Chem 2009, 284:35029-35039. 10.1074/jbc.M109.045047, 2787364, 19783651.
-
(2009)
J Biol Chem
, vol.284
, pp. 35029-35039
-
-
Doyle, P.J.1
Saeed, H.2
Hermans, A.3
Gleddie, S.C.4
Hussack, G.5
Arbabi-Ghahroudi, M.6
Seguin, C.7
Savard, M.E.8
Mackenzie, C.R.9
Hall, J.C.10
-
120
-
-
61849151339
-
"Cleavable" hapten-biotin conjugates: Preparation and use for the generation of anti-steroid single-domain antibody fragments
-
10.1016/j.ab.2009.01.004, 19454256
-
Kobayashi N, Oyama H, Nakao M, Kanda T, Banzono E, Kato Y, Karibe T, Nishio T, Goto J. "Cleavable" hapten-biotin conjugates: Preparation and use for the generation of anti-steroid single-domain antibody fragments. Anal Biochem 2009, 387:257-266. 10.1016/j.ab.2009.01.004, 19454256.
-
(2009)
Anal Biochem
, vol.387
, pp. 257-266
-
-
Kobayashi, N.1
Oyama, H.2
Nakao, M.3
Kanda, T.4
Banzono, E.5
Kato, Y.6
Karibe, T.7
Nishio, T.8
Goto, J.9
-
121
-
-
34848892716
-
Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope
-
10.1016/j.jmb.2007.08.027, 2148503, 17888451
-
Koide A, Tereshko V, Uysal S, Margalef K, Kossiakoff AA, Koide S. Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol 2007, 373:941-953. 10.1016/j.jmb.2007.08.027, 2148503, 17888451.
-
(2007)
J Mol Biol
, vol.373
, pp. 941-953
-
-
Koide, A.1
Tereshko, V.2
Uysal, S.3
Margalef, K.4
Kossiakoff, A.A.5
Koide, S.6
-
122
-
-
0034673109
-
Camelid heavy-chain variable domains provide efficient combining sites to haptens
-
10.1021/bi991830w, 10684599
-
Spinelli S, Frenken LGJ, Hermans P, Verrips T, Brown K, Tegoni M, Cambillau C. Camelid heavy-chain variable domains provide efficient combining sites to haptens. Biochemistry 2000, 39:1217-1222. 10.1021/bi991830w, 10684599.
-
(2000)
Biochemistry
, vol.39
, pp. 1217-1222
-
-
Spinelli, S.1
Frenken, L.G.J.2
Hermans, P.3
Verrips, T.4
Brown, K.5
Tegoni, M.6
Cambillau, C.7
-
123
-
-
0035800596
-
Lateral recognition of a dye hapten by a llama VHH domain
-
10.1006/jmbi.2001.4856, 11469862
-
Spinelli S, Tegoni M, Frenken L, van Vliet C, Cambillau C. Lateral recognition of a dye hapten by a llama VHH domain. J Mol Biol 2001, 311:123-129. 10.1006/jmbi.2001.4856, 11469862.
-
(2001)
J Mol Biol
, vol.311
, pp. 123-129
-
-
Spinelli, S.1
Tegoni, M.2
Frenken, L.3
van Vliet, C.4
Cambillau, C.5
-
124
-
-
67651208685
-
Hapten-induced dimerization of a single domain VHH camelid antibody
-
10.1021/bi900862r, 19572722
-
Sonneson GJ, Horn JR. Hapten-induced dimerization of a single domain VHH camelid antibody. Biochemistry 2009, 48:6693-6695. 10.1021/bi900862r, 19572722.
-
(2009)
Biochemistry
, vol.48
, pp. 6693-6695
-
-
Sonneson, G.J.1
Horn, J.R.2
-
125
-
-
0344395582
-
Beneficial properties of single-domain antibody fragments for application in immunoaffinity purification and immuno-perfusion chromatography
-
Verheesen P, ten Haaft MR, Lindner N, Verrips CT, de Haard JJW. Beneficial properties of single-domain antibody fragments for application in immunoaffinity purification and immuno-perfusion chromatography. Biochim Biophys Acta 2003, 1624:21-28.
-
(2003)
Biochim Biophys Acta
, vol.1624
, pp. 21-28
-
-
Verheesen, P.1
ten Haaft, M.R.2
Lindner, N.3
Verrips, C.T.4
de Haard, J.J.W.5
-
126
-
-
70349798567
-
Application of a novel affinity adsorbent for the capture and purification of Factor VIII compound
-
McCue JT, Selvitelli K, Walker J. Application of a novel affinity adsorbent for the capture and purification of Factor VIII compound. J Chromatog A 2009, 1261:7824-7830.
-
(2009)
J Chromatog A
, vol.1261
, pp. 7824-7830
-
-
McCue, J.T.1
Selvitelli, K.2
Walker, J.3
-
128
-
-
78349296066
-
The availability of a recombinant anti-SNAP antibody in VHH format amplifies the application flexibility of SNAP-tagged proteins
-
ID 658954
-
Aliprandi M, Sparacio E, Pivetta F, Ossolengo G, Maestro R, de Marco A. The availability of a recombinant anti-SNAP antibody in VHH format amplifies the application flexibility of SNAP-tagged proteins. J Biomed Biotechnol 2010, ID 658954.
-
(2010)
J Biomed Biotechnol
-
-
Aliprandi, M.1
Sparacio, E.2
Pivetta, F.3
Ossolengo, G.4
Maestro, R.5
de Marco, A.6
-
129
-
-
73649106906
-
Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography
-
Franco EJ, Sonneson GJ, DeLegge TJ, Hofstetter H, Horn JR, Hofstetter O. Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography. J Chromatogr B 2010, 878:177-186.
-
(2010)
J Chromatogr B
, vol.878
, pp. 177-186
-
-
Franco, E.J.1
Sonneson, G.J.2
DeLegge, T.J.3
Hofstetter, H.4
Horn, J.R.5
Hofstetter, O.6
-
130
-
-
67449132105
-
Serum-free production and purification of chimeric IgA antibodies
-
Beyer T. Serum-free production and purification of chimeric IgA antibodies. J Immunol Meth 2009, 346:26-27.
-
(2009)
J Immunol Meth
, vol.346
, pp. 26-27
-
-
Beyer, T.1
-
131
-
-
59849097833
-
Antigen-specific human polyclonal antibodies from hyperimmunized cattle
-
Kuroiwa Y, Kasinathan P, Sathiyaseelan T, Jiao JA, Matsushita H, Sathiyaseelan J, Wu H, Mellquist J, Hammitt M, Koster J, Kamoda S, Tachibana K, Ishida I, Robl JM. Antigen-specific human polyclonal antibodies from hyperimmunized cattle. Nature Biotechnol 2009, 27:173-181.
-
(2009)
Nature Biotechnol
, vol.27
, pp. 173-181
-
-
Kuroiwa, Y.1
Kasinathan, P.2
Sathiyaseelan, T.3
Jiao, J.A.4
Matsushita, H.5
Sathiyaseelan, J.6
Wu, H.7
Mellquist, J.8
Hammitt, M.9
Koster, J.10
Kamoda, S.11
Tachibana, K.12
Ishida, I.13
Robl, J.M.14
-
132
-
-
34347254260
-
Improved anti-IgG and HAS affinity ligands: Clinical application of VHH antibodies technology
-
Klooster R, Maassen BTH, Stam JC, Hermans PW, ten Haaft MR, Detmers FJM, de Haard HJ, Post JA, Verrips TC. Improved anti-IgG and HAS affinity ligands: Clinical application of VHH antibodies technology. J Immunol Meth 2007, 324:1-12.
-
(2007)
J Immunol Meth
, vol.324
, pp. 1-12
-
-
Klooster, R.1
Maassen, B.T.H.2
Stam, J.C.3
Hermans, P.W.4
ten Haaft, M.R.5
Detmers, F.J.M.6
de Haard, H.J.7
Post, J.A.8
Verrips, T.C.9
-
133
-
-
39749193861
-
A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins
-
Rothbauer U, Zolghadr K, Muyldermans S, Schepers A, Cardoso MC, Leonhardt H. A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins. Mol Cel Proteomics 2008, 7:282-289.
-
(2008)
Mol Cel Proteomics
, vol.7
, pp. 282-289
-
-
Rothbauer, U.1
Zolghadr, K.2
Muyldermans, S.3
Schepers, A.4
Cardoso, M.C.5
Leonhardt, H.6
-
134
-
-
78649644404
-
Structural and thermodynamic analysis of the GFP:GFP-nanobody complex
-
Kubala MH, Kovtun O, Alexandrov K, Collins BM. Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci 2010, 19:238-2401.
-
(2010)
Protein Sci
, vol.19
, pp. 238-2401
-
-
Kubala, M.H.1
Kovtun, O.2
Alexandrov, K.3
Collins, B.M.4
-
136
-
-
64549110877
-
Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection
-
Hellström M, Ruitenberg MJ, Pollett MA, Ehlert EM, Twisk J, Verhaagen J, Harvey AR. Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection. Gene Ther 2008, 16:521-532.
-
(2008)
Gene Ther
, vol.16
, pp. 521-532
-
-
Hellström, M.1
Ruitenberg, M.J.2
Pollett, M.A.3
Ehlert, E.M.4
Twisk, J.5
Verhaagen, J.6
Harvey, A.R.7
-
137
-
-
70449103126
-
A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells
-
10.1038/mt.2009.128, 2835045, 19532142
-
Smith RH, Levy JR, Kotin RM. A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Mol Ther 2009, 17:1888-1896. 10.1038/mt.2009.128, 2835045, 19532142.
-
(2009)
Mol Ther
, vol.17
, pp. 1888-1896
-
-
Smith, R.H.1
Levy, J.R.2
Kotin, R.M.3
-
138
-
-
79959572308
-
Capture Select
-
Capture Select. , http://www.captureselect.com
-
-
-
-
139
-
-
79959557748
-
Allele Biotechnology
-
Allele Biotechnology. , http://www.allelebiotech.com
-
-
-
-
140
-
-
77951621074
-
Antibody-mediated purification of co-expressed antigen-antibody complexes
-
Bossi S, Ferranti B, Martinelli C, Capasso P, de Marco A. Antibody-mediated purification of co-expressed antigen-antibody complexes. Prot Expr Purif 2010, 72:55-58.
-
(2010)
Prot Expr Purif
, vol.72
, pp. 55-58
-
-
Bossi, S.1
Ferranti, B.2
Martinelli, C.3
Capasso, P.4
de Marco, A.5
-
141
-
-
50849089350
-
Antibody fragments as probe in biosensor development
-
Saerens D, Huang L, Bonroy K, Muyldermans S. Antibody fragments as probe in biosensor development. Sensors 2008, 8:4669-4686.
-
(2008)
Sensors
, vol.8
, pp. 4669-4686
-
-
Saerens, D.1
Huang, L.2
Bonroy, K.3
Muyldermans, S.4
-
142
-
-
68849114030
-
Efficient, chemioselective synthesis of immunomicelles using single-domain antibodies with C-terminal thioester
-
10.1186/1472-6750-9-66, 2719619, 19619333
-
Reulen SWA, van Baal I, Raats JMH, Merckx M. Efficient, chemioselective synthesis of immunomicelles using single-domain antibodies with C-terminal thioester. BMC Biotechnol 2009, 9:66. 10.1186/1472-6750-9-66, 2719619, 19619333.
-
(2009)
BMC Biotechnol
, vol.9
, pp. 66
-
-
Reulen, S.W.A.1
van Baal, I.2
Raats, J.M.H.3
Merckx, M.4
-
143
-
-
77954034976
-
Downregulation of EGFR by a novel multivalent nanobody-liposome platform
-
10.1016/j.jconrel.2010.03.020, 20362020
-
Oliveira S, Schiffelers RM, van der Veeken J, van der Meel R, Vongpromek R, van Bergen en Henegouwen PM, Storm G, Roovers RC. Downregulation of EGFR by a novel multivalent nanobody-liposome platform. J Control Release 2010, 145:165-175. 10.1016/j.jconrel.2010.03.020, 20362020.
-
(2010)
J Control Release
, vol.145
, pp. 165-175
-
-
Oliveira, S.1
Schiffelers, R.M.2
van der Veeken, J.3
van der Meel, R.4
Vongpromek, R.5
van Bergen en Henegouwen, P.M.6
Storm, G.7
Roovers, R.C.8
-
144
-
-
77957891777
-
Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation
-
10.1039/c005279e, 20859568
-
Even-Desrumeaux K, Baty D, Chames P. Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation. Mol BioSyst 2010, 6:2241-2248. 10.1039/c005279e, 20859568.
-
(2010)
Mol BioSyst
, vol.6
, pp. 2241-2248
-
-
Even-Desrumeaux, K.1
Baty, D.2
Chames, P.3
-
145
-
-
23044489293
-
Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays
-
10.1016/j.bios.2004.11.016, 16076438
-
Huang L, Reekmans G, Saerens D, Friedt JM, Frederix F, Francis L, Muyldermans S, Campitelli A, Van Hoof C. Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays. Biosens Bioelectron 2005, 21:483-490. 10.1016/j.bios.2004.11.016, 16076438.
-
(2005)
Biosens Bioelectron
, vol.21
, pp. 483-490
-
-
Huang, L.1
Reekmans, G.2
Saerens, D.3
Friedt, J.M.4
Frederix, F.5
Francis, L.6
Muyldermans, S.7
Campitelli, A.8
Van Hoof, C.9
-
146
-
-
28544431564
-
Engineering camel single-domain antibodies and immobilization chemistry for human prostate-specific antigen sensing
-
10.1021/ac051092j, 16316161
-
Saerens D, Frederix F, Reekmans G, Conrath K, Jans K, Brys L, Huang L, Bosmans E, Maes G, Borghs G, Muyldermans S. Engineering camel single-domain antibodies and immobilization chemistry for human prostate-specific antigen sensing. Anal Chem 2005, 77:7547-7555. 10.1021/ac051092j, 16316161.
-
(2005)
Anal Chem
, vol.77
, pp. 7547-7555
-
-
Saerens, D.1
Frederix, F.2
Reekmans, G.3
Conrath, K.4
Jans, K.5
Brys, L.6
Huang, L.7
Bosmans, E.8
Maes, G.9
Borghs, G.10
Muyldermans, S.11
-
147
-
-
43249091515
-
SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression
-
Huang L, Gainkam LO, Caveliers V, Vanhove C, Keyaerts M, De Baetseliers P, Bossuyt A, Revets H, Lahoutte T. SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression. Mol Imaging Biol 2008, 10:165-175.
-
(2008)
Mol Imaging Biol
, vol.10
, pp. 165-175
-
-
Huang, L.1
Gainkam, L.O.2
Caveliers, V.3
Vanhove, C.4
Keyaerts, M.5
De Baetseliers, P.6
Bossuyt, A.7
Revets, H.8
Lahoutte, T.9
-
148
-
-
44149088593
-
Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT
-
10.2967/jnumed.107.048538, 18413403
-
Gainkam LO, Huang L, Caveliers V, Keyaerts M, Hernot S, Vaneycken I, Vanhove C, Revets H, De Baetselier P, Lahoutte T. Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT. J Nucl Med 2008, 49:788-795. 10.2967/jnumed.107.048538, 18413403.
-
(2008)
J Nucl Med
, vol.49
, pp. 788-795
-
-
Gainkam, L.O.1
Huang, L.2
Caveliers, V.3
Keyaerts, M.4
Hernot, S.5
Vaneycken, I.6
Vanhove, C.7
Revets, H.8
De Baetselier, P.9
Lahoutte, T.10
-
149
-
-
77952295436
-
Nanobodies as tools for in vivo imaging of specific immune cell types
-
10.2967/jnumed.109.070078, 20395332
-
De Groeve K, Deschacht N, De Koninck C, Caveliers V, Lahoutte T, Devoogdt N, Muyldermans S, De Baetselier P, Raes G. Nanobodies as tools for in vivo imaging of specific immune cell types. J Nucl Med 2010, 51:782-789. 10.2967/jnumed.109.070078, 20395332.
-
(2010)
J Nucl Med
, vol.51
, pp. 782-789
-
-
De Groeve, K.1
Deschacht, N.2
De Koninck, C.3
Caveliers, V.4
Lahoutte, T.5
Devoogdt, N.6
Muyldermans, S.7
De Baetselier, P.8
Raes, G.9
-
150
-
-
84855666147
-
Correlation between epidermal growth factor receptor-specific nanobody uptake and tumor burden: A tool for noninvasive monitoring of tumor response to therapy
-
PMID: 20865332
-
Tchouate Gainkam LO, Keyaerts M, Caveliers V, Devoogdt N, Vanhove C, Van Grunsven L, Muyldermans S, Lahoutte T. Correlation between epidermal growth factor receptor-specific nanobody uptake and tumor burden: A tool for noninvasive monitoring of tumor response to therapy. Mol Imaging Biol 2010, PMID: 20865332.
-
(2010)
Mol Imaging Biol
-
-
Tchouate Gainkam, L.O.1
Keyaerts, M.2
Caveliers, V.3
Devoogdt, N.4
Vanhove, C.5
Van Grunsven, L.6
Muyldermans, S.7
Lahoutte, T.8
-
151
-
-
79954991349
-
Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice
-
Tchouate Gainkam LO, Caveliers V, Devoogdt N, Vanhove C, Xavier C, Boerman O, Muyldermans S, Bossuyt A, Lahoutte T. Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice. Contrast Media Mol Imaging 2010, 6:85-92.
-
(2010)
Contrast Media Mol Imaging
, vol.6
, pp. 85-92
-
-
Tchouate Gainkam, L.O.1
Caveliers, V.2
Devoogdt, N.3
Vanhove, C.4
Xavier, C.5
Boerman, O.6
Muyldermans, S.7
Bossuyt, A.8
Lahoutte, T.9
-
152
-
-
79960188481
-
Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer
-
PMID: 21478264
-
Vaneycken I, Devoogdt N, Van Gassen N, Vincke C, Xavier C, Wernery U, Muyldermans S, Lahoutte T, Caveliers V. Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer. FASEB J 2011, PMID: 21478264.
-
(2011)
FASEB J
-
-
Vaneycken, I.1
Devoogdt, N.2
Van Gassen, N.3
Vincke, C.4
Xavier, C.5
Wernery, U.6
Muyldermans, S.7
Lahoutte, T.8
Caveliers, V.9
-
153
-
-
79953726991
-
Facile labeling of an anti-epidermal growth factor receptor nanobody with (68)Ga via a novel bifunctional desferal chelate for immuno-PET
-
10.1007/s00259-010-1700-1, 3053459, 21210114
-
Vosjan MJ, Perk LR, Roovers RC, Visser GW, Stigter-van Walsum M, van Bergen En Henegouwen PM, van Dongen GA. Facile labeling of an anti-epidermal growth factor receptor nanobody with (68)Ga via a novel bifunctional desferal chelate for immuno-PET. Eur J Nucl Med Mol Imaging 2011, 38:753-763. 10.1007/s00259-010-1700-1, 3053459, 21210114.
-
(2011)
Eur J Nucl Med Mol Imaging
, vol.38
, pp. 753-763
-
-
Vosjan, M.J.1
Perk, L.R.2
Roovers, R.C.3
Visser, G.W.4
Stigter-van Walsum, M.5
van Bergen En Henegouwen, P.M.6
van Dongen, G.A.7
-
154
-
-
0026684815
-
Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
-
Yokota T, Milenic DE, Whitiow M, Schlom J. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res 1992, 52:3402-3408.
-
(1992)
Cancer Res
, vol.52
, pp. 3402-3408
-
-
Yokota, T.1
Milenic, D.E.2
Whitiow, M.3
Schlom, J.4
-
155
-
-
53349171633
-
Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular nanobody technology
-
10.1158/1535-7163.MCT-07-2384, 18723476
-
Tijink BM, Laeremans T, Budde M, Stigter-van Walsum M, Dreier T, de Haard HJ, Leemans CR, van Dongen GA. Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular nanobody technology. Mol Cancer Ther 2008, 7:2288-2297. 10.1158/1535-7163.MCT-07-2384, 18723476.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2288-2297
-
-
Tijink, B.M.1
Laeremans, T.2
Budde, M.3
Stigter-van Walsum, M.4
Dreier, T.5
de Haard, H.J.6
Leemans, C.R.7
van Dongen, G.A.8
-
156
-
-
79953273008
-
Small unilamellar vesicles: a platform technology for molecular imaging of brain tumors
-
10.1088/0957-4484/22/19/195102, 21436507
-
Iqbal U, Albaghdadi H, Nieh MP, Tuor UI, Mester Z, Stanimirovic D, Katsaras J, Abulrob A. Small unilamellar vesicles: a platform technology for molecular imaging of brain tumors. Nanotechnology 2011, 22:195102. 10.1088/0957-4484/22/19/195102, 21436507.
-
(2011)
Nanotechnology
, vol.22
, pp. 195102
-
-
Iqbal, U.1
Albaghdadi, H.2
Nieh, M.P.3
Tuor, U.I.4
Mester, Z.5
Stanimirovic, D.6
Katsaras, J.7
Abulrob, A.8
-
157
-
-
0022519337
-
Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution
-
10.1126/science.2426778, 2426778
-
Amit AG, Mariuzza RA, Phillips SE, Poljak RJ. Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution. Science 1986, 233:747-753. 10.1126/science.2426778, 2426778.
-
(1986)
Science
, vol.233
, pp. 747-753
-
-
Amit, A.G.1
Mariuzza, R.A.2
Phillips, S.E.3
Poljak, R.J.4
-
158
-
-
0036667741
-
Crystallization of membrane proteins mediated by antibody fragments
-
10.1016/S0959-440X(02)00354-8, 12163074
-
Hunte C, Michel H. Crystallization of membrane proteins mediated by antibody fragments. Curr Opin Struct Biol 2002, 12:503-508. 10.1016/S0959-440X(02)00354-8, 12163074.
-
(2002)
Curr Opin Struct Biol
, vol.12
, pp. 503-508
-
-
Hunte, C.1
Michel, H.2
-
160
-
-
0037453089
-
Structural basis for recognition by an in vitro evolved affibody
-
10.1073/pnas.0436100100, 404300, 12604795
-
Hogbom M, Eklund M, Nygren PA, Nordlund P. Structural basis for recognition by an in vitro evolved affibody. Proc Natl Acad Sci USA 2003, 100:3191-3196. 10.1073/pnas.0436100100, 404300, 12604795.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 3191-3196
-
-
Hogbom, M.1
Eklund, M.2
Nygren, P.A.3
Nordlund, P.4
-
161
-
-
34247098240
-
Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III doman and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies
-
10.1016/j.jmb.2007.02.029, 17382960
-
Lipovšek D, Lippow SM, Hackel BJ, Gregson MW, Cheng P, Kapila A, Wittrup KD. Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III doman and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies. J Mol Biol 2007, 368:1024-1041. 10.1016/j.jmb.2007.02.029, 17382960.
-
(2007)
J Mol Biol
, vol.368
, pp. 1024-1041
-
-
Lipovšek, D.1
Lippow, S.M.2
Hackel, B.J.3
Gregson, M.W.4
Cheng, P.5
Kapila, A.6
Wittrup, K.D.7
-
162
-
-
53049085400
-
Chaperone-assisted crystallography with DARPins
-
10.1016/j.str.2008.08.010, 18940601
-
Sennhauser G, Grütter MG. Chaperone-assisted crystallography with DARPins. Structure 2008, 16:1443-1453. 10.1016/j.str.2008.08.010, 18940601.
-
(2008)
Structure
, vol.16
, pp. 1443-1453
-
-
Sennhauser, G.1
Grütter, M.G.2
-
163
-
-
46449122768
-
Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold
-
Tereshko V, Uysal S, Koide A, Margalef K, Koide S, Kossiakoff AA. Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Prot Sci 2008, 17:1175-1187.
-
(2008)
Prot Sci
, vol.17
, pp. 1175-1187
-
-
Tereshko, V.1
Uysal, S.2
Koide, A.3
Margalef, K.4
Koide, S.5
Kossiakoff, A.A.6
-
164
-
-
17844407417
-
Induced refolding of a temperature denatured llama heavy-chain antibody fragment by its antigen
-
10.1002/prot.20378, 15778955
-
Dolk E, van Vliet C, Perez JM, Vriend G, Darbon H, Ferrat G, Cambillau C, Frenken LG, Verrips T. Induced refolding of a temperature denatured llama heavy-chain antibody fragment by its antigen. Proteins 2005, 59:555-564. 10.1002/prot.20378, 15778955.
-
(2005)
Proteins
, vol.59
, pp. 555-564
-
-
Dolk, E.1
van Vliet, C.2
Perez, J.M.3
Vriend, G.4
Darbon, H.5
Ferrat, G.6
Cambillau, C.7
Frenken, L.G.8
Verrips, T.9
-
165
-
-
33847103076
-
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
-
10.1016/j.jmb.2006.12.045, 17258766
-
Stanfield RL, Dooley H, Verdino P, Flajnik MF, Wilson IA. Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding. J Mol Biol 2007, 367:358-372. 10.1016/j.jmb.2006.12.045, 17258766.
-
(2007)
J Mol Biol
, vol.367
, pp. 358-372
-
-
Stanfield, R.L.1
Dooley, H.2
Verdino, P.3
Flajnik, M.F.4
Wilson, I.A.5
-
166
-
-
0042346293
-
Crystal structure of the intrinsically flexible addition antidote MazE
-
10.1074/jbc.M302336200, 12743116
-
Loris R, Marianovsky I, Lah J, Laeremans T, Engelberg-Kulka H, Glaser G, Muyldermans S, Wyns L. Crystal structure of the intrinsically flexible addition antidote MazE. J Biol Chem 2003, 278:28252-28257. 10.1074/jbc.M302336200, 12743116.
-
(2003)
J Biol Chem
, vol.278
, pp. 28252-28257
-
-
Loris, R.1
Marianovsky, I.2
Lah, J.3
Laeremans, T.4
Engelberg-Kulka, H.5
Glaser, G.6
Muyldermans, S.7
Wyns, L.8
-
167
-
-
61449174868
-
Camelid nanobodies raised against an integral membrane enzyme, nitric oxide reductase
-
Conrath K, Pereira AS, Martins CE, Timoteo CG, Tavares P, Spinelli S, Kinne J, Flaudrops C, Cambillau C, Muyldermans S, Moura I, Moura JJ, Tegoni M, Desmyter A. Camelid nanobodies raised against an integral membrane enzyme, nitric oxide reductase. Prot Sci 2009, 18:619-628.
-
(2009)
Prot Sci
, vol.18
, pp. 619-628
-
-
Conrath, K.1
Pereira, A.S.2
Martins, C.E.3
Timoteo, C.G.4
Tavares, P.5
Spinelli, S.6
Kinne, J.7
Flaudrops, C.8
Cambillau, C.9
Muyldermans, S.10
Moura, I.11
Moura, J.J.12
Tegoni, M.13
Desmyter, A.14
-
168
-
-
59649092183
-
Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody
-
10.1016/j.str.2008.11.011, 2662362, 19217396
-
Korotkov KV, Pardon E, Steyaert J, Hol WG. Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody. Structure 2009, 17:255-265. 10.1016/j.str.2008.11.011, 2662362, 19217396.
-
(2009)
Structure
, vol.17
, pp. 255-265
-
-
Korotkov, K.V.1
Pardon, E.2
Steyaert, J.3
Hol, W.G.4
-
169
-
-
60949108827
-
Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus
-
10.1016/j.jsb.2008.11.008, 19118632
-
Lam AY, Pardon E, Korotkov KV, Hol WG, Steyaert J. Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus. J Struct Biol 2009, 166:8-15. 10.1016/j.jsb.2008.11.008, 19118632.
-
(2009)
J Struct Biol
, vol.166
, pp. 8-15
-
-
Lam, A.Y.1
Pardon, E.2
Korotkov, K.V.3
Hol, W.G.4
Steyaert, J.5
-
170
-
-
79952451439
-
Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies
-
Wu M, Park Y-J, Pardon E, Turley S, Hayhurst A, Deng J, Steyaert J, Hol WG. Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J Struct Biol 2010, 174:124-136.
-
(2010)
J Struct Biol
, vol.174
, pp. 124-136
-
-
Wu, M.1
Park, Y.-J.2
Pardon, E.3
Turley, S.4
Hayhurst, A.5
Deng, J.6
Steyaert, J.7
Hol, W.G.8
-
171
-
-
78651411166
-
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
-
10.1038/nature09648, 21228869
-
Rasmussen SGF, Choi H-J, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK. Structure of a nanobody-stabilized active state of the β2 adrenoceptor. Nature 2011, 469:175-180. 10.1038/nature09648, 21228869.
-
(2011)
Nature
, vol.469
, pp. 175-180
-
-
Rasmussen, S.G.F.1
Choi, H.-J.2
Fung, J.J.3
Pardon, E.4
Casarosa, P.5
Chae, P.S.6
Devree, B.T.7
Rosenbaum, D.M.8
Thian, F.S.9
Kobilka, T.S.10
Schnapp, A.11
Konetzki, I.12
Sunahara, R.K.13
Gellman, S.H.14
Pautsch, A.15
Steyaert, J.16
Weis, W.I.17
Kobilka, B.K.18
-
172
-
-
69249107262
-
Engineering of recombinant crystallization chaperones
-
10.1016/j.sbi.2009.04.008, 2736338, 19477632
-
Koide S. Engineering of recombinant crystallization chaperones. Curr Opin Struct Biol 2009, 19:449-457. 10.1016/j.sbi.2009.04.008, 2736338, 19477632.
-
(2009)
Curr Opin Struct Biol
, vol.19
, pp. 449-457
-
-
Koide, S.1
-
173
-
-
78650146355
-
Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein
-
10.1107/S1744309110042168, 21139215
-
Abskharon RN, Soror SH, Pardon E, El Hassan H, Legname G, Steyaert J, Wohlkonig A. Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010, 66:1644-1646. 10.1107/S1744309110042168, 21139215.
-
(2010)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.66
, pp. 1644-1646
-
-
Abskharon, R.N.1
Soror, S.H.2
Pardon, E.3
El Hassan, H.4
Legname, G.5
Steyaert, J.6
Wohlkonig, A.7
-
174
-
-
0042467574
-
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
-
10.1038/nature01870, 12917687
-
Dumoulin M, Last AM, Desmyter A, Decanniere K, Canet D, Larsson G, Spencer A, Archer DB, Sasse J, Muyldermans S, Wyns L, Redfield C, Matagne A, Robinson CV, Dobson CM. A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature 2003, 424:783-788. 10.1038/nature01870, 12917687.
-
(2003)
Nature
, vol.424
, pp. 783-788
-
-
Dumoulin, M.1
Last, A.M.2
Desmyter, A.3
Decanniere, K.4
Canet, D.5
Larsson, G.6
Spencer, A.7
Archer, D.B.8
Sasse, J.9
Muyldermans, S.10
Wyns, L.11
Redfield, C.12
Matagne, A.13
Robinson, C.V.14
Dobson, C.M.15
-
175
-
-
37649019187
-
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils
-
10.1073/pnas.0703793104, 2148273, 18042730
-
Habicht G, Haupt C, Friedrich RP, Hortschansky P, Sachse C, Meinhardt J, Wieligmann K, Gellermann GP, Brodhun M, Götz J, Halbhuber KJ, Röcken C, Horn U, Fändrich M. Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci USA 2007, 104:19232-19237. 10.1073/pnas.0703793104, 2148273, 18042730.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19232-19237
-
-
Habicht, G.1
Haupt, C.2
Friedrich, R.P.3
Hortschansky, P.4
Sachse, C.5
Meinhardt, J.6
Wieligmann, K.7
Gellermann, G.P.8
Brodhun, M.9
Götz, J.10
Halbhuber, K.J.11
Röcken, C.12
Horn, U.13
Fändrich, M.14
-
176
-
-
58249104047
-
Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation
-
10.1016/j.molimm.2008.09.008, 18930548
-
Lafaye P, Achour I, England P, Duyckaerts C, Rougeon F. Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation. Mol Immunol 2009, 46:695-704. 10.1016/j.molimm.2008.09.008, 18930548.
-
(2009)
Mol Immunol
, vol.46
, pp. 695-704
-
-
Lafaye, P.1
Achour, I.2
England, P.3
Duyckaerts, C.4
Rougeon, F.5
-
177
-
-
85055769426
-
Nanobody specific for oligomeric beta-amyloyd stabilizes nontoxic form
-
PMID: 21067847
-
Kasturirangan S, Li L, Emadi S, Boddapati S, Schulz P, Sierks MR. Nanobody specific for oligomeric beta-amyloyd stabilizes nontoxic form. Neurobiol Aging 2010, PMID: 21067847.
-
(2010)
Neurobiol Aging
-
-
Kasturirangan, S.1
Li, L.2
Emadi, S.3
Boddapati, S.4
Schulz, P.5
Sierks, M.R.6
-
178
-
-
77952852954
-
Engineered proteolytic nanobodies reduce Abeta burden and ameliorate Abeta-induced cytotxicity
-
10.1021/bi902030m, 20429609
-
Kasturirangan S, Boddapati S, Sierks MR. Engineered proteolytic nanobodies reduce Abeta burden and ameliorate Abeta-induced cytotxicity. Biochemistry 2010, 49:4501-4508. 10.1021/bi902030m, 20429609.
-
(2010)
Biochemistry
, vol.49
, pp. 4501-4508
-
-
Kasturirangan, S.1
Boddapati, S.2
Sierks, M.R.3
-
179
-
-
79952152956
-
Atomic structure of a nanobody-trapped domain-swapped dimmer of an amyloidogenic {beta}2-microglobulin variant
-
10.1073/pnas.1008560108, 21220305
-
Domanska K, Vanderhaegen S, Srinivasan V, Pardon E, Dupeux F, Marquez JA, Giorgetti S, Stoppini M, Wyns L, Bellotti V, Steyaert J. Atomic structure of a nanobody-trapped domain-swapped dimmer of an amyloidogenic {beta}2-microglobulin variant. Proc Natl Acad Sci USA 2011, 108:1314-1319. 10.1073/pnas.1008560108, 21220305.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 1314-1319
-
-
Domanska, K.1
Vanderhaegen, S.2
Srinivasan, V.3
Pardon, E.4
Dupeux, F.5
Marquez, J.A.6
Giorgetti, S.7
Stoppini, M.8
Wyns, L.9
Bellotti, V.10
Steyaert, J.11
-
180
-
-
79251567055
-
Crystal structure of the amylod-{beta} p3 fragment provides a model for oligomeric formation in Alzheimer's disease
-
10.1523/JNEUROSCI.4259-10.2011, 21273426
-
Streltsov VA, Varghese JN, Masters CL, Nuttal SD. Crystal structure of the amylod-{beta} p3 fragment provides a model for oligomeric formation in Alzheimer's disease. J Neurosci 2011, 31:1419-1426. 10.1523/JNEUROSCI.4259-10.2011, 21273426.
-
(2011)
J Neurosci
, vol.31
, pp. 1419-1426
-
-
Streltsov, V.A.1
Varghese, J.N.2
Masters, C.L.3
Nuttal, S.D.4
-
181
-
-
79952009210
-
Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition
-
10.1016/j.jmb.2011.01.017, 21238460
-
Oyen D, Srinivasan V, Steyaert J, Barlow JN. Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J Mol Biol 2011, 407:138-148. 10.1016/j.jmb.2011.01.017, 21238460.
-
(2011)
J Mol Biol
, vol.407
, pp. 138-148
-
-
Oyen, D.1
Srinivasan, V.2
Steyaert, J.3
Barlow, J.N.4
-
182
-
-
67349089888
-
Substrate-dependent modulation of enzyme activity by allosteric effector antibodies
-
Barlow JN, Conrath K, Steyaert J. Substrate-dependent modulation of enzyme activity by allosteric effector antibodies. Biochim Biophys Acta 2009, 1794:1259-1268.
-
(2009)
Biochim Biophys Acta
, vol.1794
, pp. 1259-1268
-
-
Barlow, J.N.1
Conrath, K.2
Steyaert, J.3
-
183
-
-
79952281440
-
The development of activating and inhibiting camelid VHH domains against human protein kinase C epsilon
-
10.1016/j.ejps.2010.12.012, 21220006
-
Paalanen MM, Ekokoski E, El Khattabi M, Tuominen RK, Verrips CT, Boonstra J, Blanchetot C. The development of activating and inhibiting camelid VHH domains against human protein kinase C epsilon. Eur J Pharm Sci 2011, 42:332-339. 10.1016/j.ejps.2010.12.012, 21220006.
-
(2011)
Eur J Pharm Sci
, vol.42
, pp. 332-339
-
-
Paalanen, M.M.1
Ekokoski, E.2
El Khattabi, M.3
Tuominen, R.K.4
Verrips, C.T.5
Boonstra, J.6
Blanchetot, C.7
-
184
-
-
33645241975
-
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies
-
10.1073/pnas.0505379103, 1450215, 16537393
-
De Genst E, Silence K, Decanniere K, Conrath K, Loris R, Kinne J, Muyldermans S, Wyns L. Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc Natl Acad Sci USA 2006, 103:4586-4591. 10.1073/pnas.0505379103, 1450215, 16537393.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4586-4591
-
-
De Genst, E.1
Silence, K.2
Decanniere, K.3
Conrath, K.4
Loris, R.5
Kinne, J.6
Muyldermans, S.7
Wyns, L.8
-
185
-
-
33748791745
-
Reliable and controllable antibody fragment selections from camelid non-immune libraries for target validation
-
Verheesen P, Roussis A, de Haard HJ, Groot EH, Stam JC, den Dunnen JT, Frants RR, Verkleij AJ, Theo Verrips C, van der Maarel SM. Reliable and controllable antibody fragment selections from camelid non-immune libraries for target validation. Biochim Biophys Acta 2006, 1764:1307-1319.
-
(2006)
Biochim Biophys Acta
, vol.1764
, pp. 1307-1319
-
-
Verheesen, P.1
Roussis, A.2
de Haard, H.J.3
Groot, E.H.4
Stam, J.C.5
den Dunnen, J.T.6
Frants, R.R.7
Verkleij, A.J.8
Theo Verrips, C.9
van der Maarel, S.M.10
-
186
-
-
40549114286
-
Shark IgNAR antibody mimotopes target a murine immunoglobulin through extended CDR3 loop structure
-
10.1002/prot.21663, 17932913
-
Simmons DP, Streltsov VA, Dolezal O, Hudson PJ, Coley AM, Foley M, Proll DF, Nuttall SD. Shark IgNAR antibody mimotopes target a murine immunoglobulin through extended CDR3 loop structure. Proteins 2008, 71:119-130. 10.1002/prot.21663, 17932913.
-
(2008)
Proteins
, vol.71
, pp. 119-130
-
-
Simmons, D.P.1
Streltsov, V.A.2
Dolezal, O.3
Hudson, P.J.4
Coley, A.M.5
Foley, M.6
Proll, D.F.7
Nuttall, S.D.8
-
187
-
-
79956188243
-
Single-domain antibodies that compete with the natural ligand Fibroblast Growth Factor block the internalization of the Fibroblast Growth Factor Receptor1
-
10.1016/j.bbrc.2011.04.090, 21539817
-
Veggiani G, Ossolengo G, Aliprandi M, Cavallaro U, de Marco A. Single-domain antibodies that compete with the natural ligand Fibroblast Growth Factor block the internalization of the Fibroblast Growth Factor Receptor1. Biochem Biophys Res Comm 2011, 408:692-696. 10.1016/j.bbrc.2011.04.090, 21539817.
-
(2011)
Biochem Biophys Res Comm
, vol.408
, pp. 692-696
-
-
Veggiani, G.1
Ossolengo, G.2
Aliprandi, M.3
Cavallaro, U.4
de Marco, A.5
-
188
-
-
0032797898
-
Development of an optimized expression system for the screening of antibody libraries displayed on the Escherichia coli surface
-
Daugherty PS, Olsen MJ, Iverson BL, Georgiou G. Development of an optimized expression system for the screening of antibody libraries displayed on the Escherichia coli surface. Prot Engineer 1999, 12:613-621.
-
(1999)
Prot Engineer
, vol.12
, pp. 613-621
-
-
Daugherty, P.S.1
Olsen, M.J.2
Iverson, B.L.3
Georgiou, G.4
-
189
-
-
0037318058
-
Flow-cytometry isolation of human antibodies from a nonimmune Saccharomices cerevisiae surface display library
-
10.1038/nbt785, 12536217
-
Feldhaus MJ, Siegel RW, Opresko LK, Coleman JR, Weaver Feldhaus JM, Yeung YA. Flow-cytometry isolation of human antibodies from a nonimmune Saccharomices cerevisiae surface display library. Nat Biotechnol 2003, 21:163-170. 10.1038/nbt785, 12536217.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 163-170
-
-
Feldhaus, M.J.1
Siegel, R.W.2
Opresko, L.K.3
Coleman, J.R.4
Weaver Feldhaus, J.M.5
Yeung, Y.A.6
-
190
-
-
33645774926
-
Applications of cell sorting in biotechnology
-
10.1186/1475-2859-5-12, 1435767, 16551353
-
Mattanovich D, Borth N. Applications of cell sorting in biotechnology. Microb Cell Fact 2006, 5:12. 10.1186/1475-2859-5-12, 1435767, 16551353.
-
(2006)
Microb Cell Fact
, vol.5
, pp. 12
-
-
Mattanovich, D.1
Borth, N.2
-
191
-
-
33847634290
-
Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target
-
10.1038/nmeth1003, 17327848
-
Zahnd C, Amstutz P, Plückthun A. Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target. Nat Methods 2007, 4:269-279. 10.1038/nmeth1003, 17327848.
-
(2007)
Nat Methods
, vol.4
, pp. 269-279
-
-
Zahnd, C.1
Amstutz, P.2
Plückthun, A.3
-
192
-
-
78149322603
-
Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization
-
10.1038/nbt.1694, 20972421
-
Mao H, Graziano JJ, Chase TMA, Bentley CA, Bazirgan OA, Reddy NP, Song BD, Smider VV. Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization. Nat Biotechnol 2010, 28:1195-2202. 10.1038/nbt.1694, 20972421.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1195-2202
-
-
Mao, H.1
Graziano, J.J.2
Chase, T.M.A.3
Bentley, C.A.4
Bazirgan, O.A.5
Reddy, N.P.6
Song, B.D.7
Smider, V.V.8
-
193
-
-
46849103828
-
Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance
-
10.1016/j.addr.2008.04.012, 2820307, 18541331
-
Thurber GM, Schmidt MM, Wittrup KD. Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Adv Drug Deliv Rev 2008, 60:1421-1434. 10.1016/j.addr.2008.04.012, 2820307, 18541331.
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 1421-1434
-
-
Thurber, G.M.1
Schmidt, M.M.2
Wittrup, K.D.3
-
194
-
-
66249109940
-
Affinity and avidity in antibody-based tumor targeting
-
10.1089/cbr.2009.0627, 2902227, 19409036
-
Rudnick SI, Adams GP. Affinity and avidity in antibody-based tumor targeting. Cancer Biother Radiopharm 2009, 24:155-160. 10.1089/cbr.2009.0627, 2902227, 19409036.
-
(2009)
Cancer Biother Radiopharm
, vol.24
, pp. 155-160
-
-
Rudnick, S.I.1
Adams, G.P.2
-
195
-
-
62149103745
-
A novel Ecotin-Ubiquitin-Tag (ECUT) for efficient, soluble peptide production in the periplasm of Escherichia coli
-
10.1186/1475-2859-8-7, 2649888, 19159462
-
Paal M, Heel T, Schneider R, Auer B. A novel Ecotin-Ubiquitin-Tag (ECUT) for efficient, soluble peptide production in the periplasm of Escherichia coli. Microb Cell Fact 2009, 8:7. 10.1186/1475-2859-8-7, 2649888, 19159462.
-
(2009)
Microb Cell Fact
, vol.8
, pp. 7
-
-
Paal, M.1
Heel, T.2
Schneider, R.3
Auer, B.4
-
196
-
-
66949126546
-
Strategies for successful recombinant expression of disulfide bond-dependent proteins in Escherichia coli
-
10.1186/1475-2859-8-26, 2689190, 19442264
-
de Marco A. Strategies for successful recombinant expression of disulfide bond-dependent proteins in Escherichia coli. Microb Cell Fact 2009, 8:26. 10.1186/1475-2859-8-26, 2689190, 19442264.
-
(2009)
Microb Cell Fact
, vol.8
, pp. 26
-
-
de Marco, A.1
-
197
-
-
0142232284
-
The production of antibody fragments and antibody fusion proteins by yeast and filamentous fungi
-
10.1186/1475-2859-2-1, 149433, 12605725
-
Joosten V, Lokman C, van den Hondel CAMJJ, Punt PJ. The production of antibody fragments and antibody fusion proteins by yeast and filamentous fungi. Microb Cell Fact 2003, 2:1. 10.1186/1475-2859-2-1, 149433, 12605725.
-
(2003)
Microb Cell Fact
, vol.2
, pp. 1
-
-
Joosten, V.1
Lokman, C.2
van den Hondel, C.A.M.J.J.3
Punt, P.J.4
-
198
-
-
78651484550
-
Disruption of reducing pathways is not essential for efficient disulfide bond formation in the cytoplasm of E. coli
-
2946281, 20836848
-
Hatahet F, Nguyen VD, Salo KEH, Ruddock LW. Disruption of reducing pathways is not essential for efficient disulfide bond formation in the cytoplasm of E. coli. Microb Cell Fact 2010, 9:67. 2946281, 20836848.
-
(2010)
Microb Cell Fact
, vol.9
, pp. 67
-
-
Hatahet, F.1
Nguyen, V.D.2
Salo, K.E.H.3
Ruddock, L.W.4
-
199
-
-
78650965365
-
Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E. coli
-
10.1186/1475-2859-10-1, 3022669, 21211066
-
Nguyen VD, Hatahet F, Salo KEH, Enlund E, Zhang C, Ruddock LW. Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E. coli. Microb Cell Fact 2011, 10:1. 10.1186/1475-2859-10-1, 3022669, 21211066.
-
(2011)
Microb Cell Fact
, vol.10
, pp. 1
-
-
Nguyen, V.D.1
Hatahet, F.2
Salo, K.E.H.3
Enlund, E.4
Zhang, C.5
Ruddock, L.W.6
-
200
-
-
79959565723
-
Improved quantitative and qualitative production of single-domain intrabodies mediated by the co-expression of Erv1p sulfhydryl oxidase
-
PMID: 201. 21421053
-
Veggiani G, de Marco A. Improved quantitative and qualitative production of single-domain intrabodies mediated by the co-expression of Erv1p sulfhydryl oxidase. Prot Expr Purif 2011, PMID: 201. 21421053.
-
(2011)
Prot Expr Purif
-
-
Veggiani, G.1
de Marco, A.2
-
201
-
-
79952399087
-
Beyond natural antibodies: the power of in vitro display technologies
-
10.1038/nbt.1791, 21390033
-
Bradbury ARM, Sidhu S, Dübel S, McCafferty J. Beyond natural antibodies: the power of in vitro display technologies. Nat Biotechnol 2011, 29:245-254. 10.1038/nbt.1791, 21390033.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 245-254
-
-
Bradbury, A.R.M.1
Sidhu, S.2
Dübel, S.3
McCafferty, J.4
|