Viral clearance without destruction of infected cells during acute HBV infection

Science

Volumn 284, Issue 5415, 1999, Pages 825-829

  Guidotti, Luca G ^a   Rochford, Rosemary ^b   Chung, Josan ^a   Shapiro, Max ^c   Purcell, Robert ^d   Chisari, Francis V ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c BIOQUAL INC   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DESTRUCTION; CELL NUCLEUS; CHIMPANZEE; HEPATITIS B; HEPATITIS B VIRUS; LIVER CELL; LYMPHOCYTIC INFILTRATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS GENE;

ACUTE DISEASE; ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; DNA, CIRCULAR; DNA, VIRAL; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; KILLER CELLS, NATURAL; LIVER; MICE; MICE, TRANSGENIC; PAN TROGLODYTES; T-LYMPHOCYTES; TIME FACTORS; VIRUS REPLICATION;

EID: 0033617583     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5415.825     Document Type: Article

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28. We thank D. Bylund and the Scripps Immunology Reference Laboratory for performing serum HBV DNA quantitation; R. Engle, Division of Molecular Virology, Georgetown University Medical Center, for performing serological assays; R. Koch, H. McClary, and M. Pagels for technical assistance; and J. Newmann for help with manuscript preparation. Supported by grants R37 CA40489, R01 AI20001, and R01 AI40696 from the NIH. This is manuscript number 11995-MEM from The Scripps Research Institute.