-
1
-
-
79960693457
-
How big a problem is non-alcoholic fatty liver disease?
-
Anstee QM, McPherson S, Day CP. 2011. How big a problem is non-alcoholic fatty liver disease? Br. Med. J. 343:d3897
-
(2011)
Br. Med. J.
, vol.343
, pp. d3897
-
-
Anstee, Q.M.1
McPherson, S.2
Day, C.P.3
-
2
-
-
40849083460
-
Non-alcoholic fatty liver disease: The mist gradually clears
-
de Alwis NM, Day CP. 2008. Non-alcoholic fatty liver disease: The mist gradually clears. J. Hepatol. 48(Suppl. 1):S104-12
-
(2008)
J. Hepatol.
, vol.48
, pp. S104-S112
-
-
De Alwis, N.M.1
Day, C.P.2
-
3
-
-
0036829092
-
AGA technical review on nonalcoholic fatty liver disease
-
Sanyal AJ, Am. Gastroenterol. Assoc. 2002. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 123:1705-25
-
(2002)
Gastroenterology
, vol.123
, pp. 1705-1725
-
-
Am. Gastroenterol. Assoc1
Sanyal, A.J.2
-
4
-
-
80555136061
-
Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
-
Musso G, Gambino R, Cassader M, Pagano G. 2011. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann. Med. 43:617-49
-
(2011)
Ann. Med.
, vol.43
, pp. 617-649
-
-
Musso, G.1
Gambino, R.2
Cassader, M.3
Pagano, G.4
-
5
-
-
33750606061
-
Long-term follow-up of patients with NAFLD and elevated liver enzymes
-
Ekstedt M, Franzen LE, Mathiesen UL, Thorelius L, Holmqvist M, et al. 2006. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 44:865-73
-
(2006)
Hepatology
, vol.44
, pp. 865-873
-
-
Ekstedt, M.1
Franzen, L.E.2
Mathiesen, U.L.3
Thorelius, L.4
Holmqvist, M.5
-
6
-
-
84856400671
-
A phase 2, randomized, doubleblind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis
-
Ratziu V, Sheikh MY, Sanyal AJ, Lim JK, Conjeevaram H, et al. 2012. A phase 2, randomized, doubleblind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis. Hepatology 55:419-28
-
(2012)
Hepatology
, vol.55
, pp. 419-428
-
-
Ratziu, V.1
Sheikh, M.Y.2
Sanyal, A.J.3
Lim, J.K.4
Conjeevaram, H.5
-
7
-
-
77951493150
-
Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease
-
Das K, Das K, Mukherjee PS, Ghosh A, Ghosh S, et al. 2010. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology 51:1593-602
-
(2010)
Hepatology
, vol.51
, pp. 1593-1602
-
-
Das, K.1
Das, K.2
Mukherjee, P.S.3
Ghosh, A.4
Ghosh, S.5
-
8
-
-
37349053742
-
Impact of fatty liver disease on health care utilization and costs in a general population: A 5-year observation
-
Baumeister SE, VolzkeH,Marschall P, John U, Schmidt CO, et al. 2008. Impact of fatty liver disease on health care utilization and costs in a general population: A 5-year observation. Gastroenterology 134:85-94
-
(2008)
Gastroenterology
, vol.134
, pp. 85-94
-
-
Baumeister, S.E.1
Volzke, H.2
Marschall, P.3
John, U.4
Schmidt, C.O.5
-
9
-
-
11144264156
-
Nonalcoholic fatty liver disease: A review of current understanding and future impact
-
Charlton M. 2004. Nonalcoholic fatty liver disease: A review of current understanding and future impact. Clin. Gastroenterol. Hepatol. 2:1048-58
-
(2004)
Clin. Gastroenterol. Hepatol.
, vol.2
, pp. 1048-1058
-
-
Charlton, M.1
-
12
-
-
20444443042
-
Sampling variability of liver biopsy in nonalcoholic fatty liver disease
-
Ratziu V, Charlotte F, Heurtier A, Gombert S, Giral P, et al. 2005. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 128:1898-906
-
(2005)
Gastroenterology
, vol.128
, pp. 1898-1906
-
-
Ratziu, V.1
Charlotte, F.2
Heurtier, A.3
Gombert, S.4
Giral, P.5
-
13
-
-
70349770695
-
Epidemiology and natural history of non-alcoholic steatohepatitis
-
Argo CK, Caldwell SH. 2009. Epidemiology and natural history of non-alcoholic steatohepatitis. Clin. Liver Dis. 13:511-31
-
(2009)
Clin. Liver Dis.
, vol.13
, pp. 511-531
-
-
Argo, C.K.1
Caldwell, S.H.2
-
14
-
-
68049120181
-
Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
-
Schwenzer NF, Springer F, Schraml C, Stefan N, Machann J, Schick F. 2009. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J. Hepatol. 51:433-45
-
(2009)
J. Hepatol.
, vol.51
, pp. 433-445
-
-
Schwenzer, N.F.1
Springer, F.2
Schraml, C.3
Stefan, N.4
Machann, J.5
Schick, F.6
-
15
-
-
10844240700
-
Hepatic triglyceride content and its relation to body adiposity: A magnetic resonance imaging and proton magnetic resonance spectroscopy study
-
Thomas EL, Hamilton G, PatelN,O'Dwyer R, Dore CJ, et al. 2005. Hepatic triglyceride content and its relation to body adiposity: A magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut 54:122-27
-
(2005)
Gut
, vol.54
, pp. 122-127
-
-
Thomas, E.L.1
Hamilton, G.2
Patel, N.3
O'Dwyer, R.4
Dore, C.J.5
-
16
-
-
84861543083
-
The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
-
Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, et al. 2012. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 55:2005-23
-
(2012)
Hepatology
, vol.55
, pp. 2005-2023
-
-
Chalasani, N.1
Younossi, Z.2
Lavine, J.E.3
Diehl, A.M.4
Brunt, E.M.5
-
17
-
-
0036729447
-
The utility of radiological imaging in nonalcoholic fatty liver disease
-
Saadeh S, Younossi ZM, Remer EM,Gramlich T, Ong JP, et al. 2002. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 123:745-50
-
(2002)
Gastroenterology
, vol.123
, pp. 745-750
-
-
Saadeh, S.1
Younossi, Z.M.2
Remer, E.M.3
Gramlich, T.4
Ong, J.P.5
-
18
-
-
71849092184
-
Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective study
-
Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ. 2009. Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective study. J. Hepatol. 51:1061-67
-
(2009)
J. Hepatol.
, vol.51
, pp. 1061-1067
-
-
Dasarathy, S.1
Dasarathy, J.2
Khiyami, A.3
Joseph, R.4
Lopez, R.5
McCullough, A.J.6
-
19
-
-
0037566201
-
Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
-
Mofrad P, Contos MJ, Haque M, Sargeant C, Fisher RA, et al. 2003. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 37:1286-92
-
(2003)
Hepatology
, vol.37
, pp. 1286-1292
-
-
Mofrad, P.1
Contos, M.J.2
Haque, M.3
Sargeant, C.4
Fisher, R.A.5
-
20
-
-
79960029926
-
Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
-
Vernon G, Baranova A, Younossi ZM. 2011. Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 34:274-85
-
(2011)
Aliment. Pharmacol. Ther.
, vol.34
, pp. 274-285
-
-
Vernon, G.1
Baranova, A.2
Younossi, Z.M.3
-
21
-
-
83555165946
-
Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort
-
Armstrong MJ, Houlihan DD, Bentham L, Shaw JC, Cramb R, et al. 2012. Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort. J. Hepatol. 56:234-40
-
(2012)
J. Hepatol.
, vol.56
, pp. 234-240
-
-
Armstrong, M.J.1
Houlihan, D.D.2
Bentham, L.3
Shaw, J.C.4
Cramb, R.5
-
22
-
-
10644220306
-
Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
-
Browning JD, Szczepaniak LS, Dobbins R, Nurenberg P, Horton JD, et al. 2004. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40:1387-95
-
(2004)
Hepatology
, vol.40
, pp. 1387-1395
-
-
Browning, J.D.1
Szczepaniak, L.S.2
Dobbins, R.3
Nurenberg, P.4
Horton, J.D.5
-
23
-
-
12144259379
-
Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
-
Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, et al. 2005. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am. J. Physiol. Endocrinol. Metab. 288:E462-68
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.288
, pp. E462-E468
-
-
Szczepaniak, L.S.1
Nurenberg, P.2
Leonard, D.3
Browning, J.D.4
Reingold, J.S.5
-
24
-
-
0037221394
-
Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States
-
Ruhl CE, Everhart JE. 2003. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 124:71-79
-
(2003)
Gastroenterology
, vol.124
, pp. 71-79
-
-
Ruhl, C.E.1
Everhart, J.E.2
-
25
-
-
59349089179
-
Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests
-
MinerviniMI, Ruppert K, Fontes P, Volpes R, Vizzini G, et al. 2009. Liver biopsy findings from healthy potential living liver donors: reasons for disqualification, silent diseases and correlation with liver injury tests. J. Hepatol. 50:501-10
-
(2009)
J. Hepatol.
, vol.50
, pp. 501-510
-
-
Minervini, M.I.1
Ruppert, K.2
Fontes, P.3
Volpes, R.4
Vizzini, G.5
-
26
-
-
23744508743
-
Preoperative donor liver biopsy for adult living donor liver transplantation: Risks and benefits
-
Nadalin S, Malago M, Valentin-Gamazo C, Testa G, Baba HA, et al. 2005. Preoperative donor liver biopsy for adult living donor liver transplantation: risks and benefits. Liver Transplant. 11:980-86
-
(2005)
Liver Transplant.
, vol.11
, pp. 980-986
-
-
Nadalin, S.1
Malago, M.2
Valentin-Gamazo, C.3
Testa, G.4
Baba, H.A.5
-
27
-
-
33645236697
-
Living donor liver transplantation: Histological abnormalities found on liver biopsies of apparently healthy potential donors
-
Tran TT, Changsri C, Shackleton CR, Poordad FF, Nissen NN, et al. 2006. Living donor liver transplantation: histological abnormalities found on liver biopsies of apparently healthy potential donors. J. Gastroenterol. Hepatol. 21:381-83
-
(2006)
J. Gastroenterol. Hepatol.
, vol.21
, pp. 381-383
-
-
Tran, T.T.1
Changsri, C.2
Shackleton, C.R.3
Poordad, F.F.4
Nissen, N.N.5
-
28
-
-
0036911218
-
One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantation
-
Ryan CK, Johnson LA, Germin BI, Marcos A. 2002. One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantation. Liver Transplant. 8:1114-22
-
(2002)
Liver Transplant.
, vol.8
, pp. 1114-1122
-
-
Ryan, C.K.1
Johnson, L.A.2
Germin, B.I.3
Marcos, A.4
-
30
-
-
34247605492
-
Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
-
Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, et al. 2007. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 30:1212-18
-
(2007)
Diabetes Care
, vol.30
, pp. 1212-1218
-
-
Targher, G.1
Bertolini, L.2
Padovani, R.3
Rodella, S.4
Tessari, R.5
-
31
-
-
24044467100
-
Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults
-
Jimba S, Nakagami T, Takahashi M, Wakamatsu T, Hirota Y, et al. 2005. Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet. Med. 22:1141-45
-
(2005)
Diabet. Med.
, vol.22
, pp. 1141-1145
-
-
Jimba, S.1
Nakagami, T.2
Takahashi, M.3
Wakamatsu, T.4
Hirota, Y.5
-
32
-
-
78650486196
-
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
-
Williams CD, Stengel J, Asike MI, TorresDM, Shaw J, et al. 2011. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology 140:124-31
-
(2011)
Gastroenterology
, vol.140
, pp. 124-131
-
-
Williams, C.D.1
Stengel, J.2
Asike, M.I.3
Torres, D.M.4
Shaw, J.5
-
33
-
-
79956062113
-
Prevalence of and risk factors for hepatic steatosis and nonalcoholic fatty liver disease in people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study
-
Williamson RM, Price JF, Glancy S, Perry E, Nee LD, et al. 2011. Prevalence of and risk factors for hepatic steatosis and nonalcoholic fatty liver disease in people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study. Diabetes Care 34:1139-44
-
(2011)
Diabetes Care
, vol.34
, pp. 1139-1144
-
-
Williamson, R.M.1
Price, J.F.2
Glancy, S.3
Perry, E.4
Nee, L.D.5
-
34
-
-
0025260531
-
Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
-
Wanless IR, Lentz JS. 1990. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 12:1106-10
-
(1990)
Hepatology
, vol.12
, pp. 1106-1110
-
-
Wanless, I.R.1
Lentz, J.S.2
-
35
-
-
0024578117
-
Liver pathology in diabetes mellitus and morbid obesity. Clinical, pathological, and biochemical considerations
-
Silverman JF, Pories WJ, Caro JF. 1989. Liver pathology in diabetes mellitus and morbid obesity. Clinical, pathological, and biochemical considerations. Pathol. Annu. 24(Pt 1):275-302
-
(1989)
Pathol. Annu.
, vol.24
, pp. 275-302
-
-
Silverman, J.F.1
Pories, W.J.2
Caro, J.F.3
-
36
-
-
79960847840
-
Nonalcoholic fatty liver disease and diabetes mellitus: Pathogenesis and treatment
-
Smith BW, Adams LA. 2011. Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment. Nat. Rev. Endocrinol. 7:456-65
-
(2011)
Nat. Rev. Endocrinol.
, vol.7
, pp. 456-465
-
-
Smith, B.W.1
Adams, L.A.2
-
37
-
-
56649112801
-
Diagnosis of nonalcoholic fatty liver disease: Invasive versus noninvasive
-
Wieckowska A, Feldstein AE. 2008. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin. Liver Dis. 28:386-95
-
(2008)
Semin. Liver Dis.
, vol.28
, pp. 386-395
-
-
Wieckowska, A.1
Feldstein, A.E.2
-
38
-
-
84911948591
-
Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: A prospective study
-
Loomba R, Wolfson T, Ang B, Hooker J, Behling C, et al. 2014. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: A prospective study. Hepatology 60:1920-28
-
(2014)
Hepatology
, vol.60
, pp. 1920-1928
-
-
Loomba, R.1
Wolfson, T.2
Ang, B.3
Hooker, J.4
Behling, C.5
-
39
-
-
84890569059
-
Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease
-
Banerjee R, Pavlides M, Tunnicliffe EM, Piechnik SK, SaraniaN, et al. 2014. Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease. J. Hepatol. 60:69-77
-
(2014)
J. Hepatol.
, vol.60
, pp. 69-77
-
-
Banerjee, R.1
Pavlides, M.2
Tunnicliffe, E.M.3
Piechnik, S.K.4
Sarania, N.5
-
40
-
-
84892793168
-
Non-alcoholic fatty liver disease: Non-invasive investigation and risk stratification
-
Dyson JK, McPherson S, AnsteeQM. 2013. Non-alcoholic fatty liver disease: non-invasive investigation and risk stratification. J. Clin. Pathol. 66:1033-45
-
(2013)
J. Clin. Pathol.
, vol.66
, pp. 1033-1045
-
-
Dyson, J.K.1
McPherson, S.2
Anstee, Q.M.3
-
41
-
-
84913545865
-
Pathological features of fatty liver disease
-
Yeh MM, Brunt EM. 2014. Pathological features of fatty liver disease. Gastroenterology 147:754-64
-
(2014)
Gastroenterology
, vol.147
, pp. 754-764
-
-
Yeh, M.M.1
Brunt, E.M.2
-
42
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, et al. 2005. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313-21
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
Brunt, E.M.2
Van Natta, M.3
Behling, C.4
Contos, M.J.5
-
43
-
-
40949123364
-
Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis
-
Lackner C,Gogg-Kamerer M, Zatloukal K, Stumptner C, Brunt EM,DenkH. 2008. Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis. J. Hepatol. 48:821-28
-
(2008)
J. Hepatol.
, vol.48
, pp. 821-828
-
-
Lackner, C.1
Gogg-Kamerer, M.2
Zatloukal, K.3
Stumptner, C.4
Brunt, E.M.5
Denk, H.6
-
44
-
-
63349106888
-
Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
-
Brunt EM, Kleiner DE, Wilson LA, Unalp A, Behling CE, et al. 2009. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network. Hepatology 49:809-20
-
(2009)
Hepatology
, vol.49
, pp. 809-820
-
-
Brunt, E.M.1
Kleiner, D.E.2
Wilson, L.A.3
Unalp, A.4
Behling, C.E.5
-
45
-
-
0033200054
-
Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions
-
Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. 1999. Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 94:2467-74
-
(1999)
Am. J. Gastroenterol.
, vol.94
, pp. 2467-2474
-
-
Brunt, E.M.1
Janney, C.G.2
Di Bisceglie, A.M.3
Neuschwander-Tetri, B.A.4
Bacon, B.R.5
-
46
-
-
34447100647
-
Progressive fibrosis in nonalcoholic steatohepatitis: Association with altered regeneration and a ductular reaction
-
Richardson MM, Jonsson JR, Powell EE, Brunt EM, Neuschwander-Tetri BA, et al. 2007. Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction. Gastroenterology 133:80-90
-
(2007)
Gastroenterology
, vol.133
, pp. 80-90
-
-
Richardson, M.M.1
Jonsson, J.R.2
Powell, E.E.3
Brunt, E.M.4
Neuschwander-Tetri, B.A.5
-
47
-
-
79952231349
-
Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: Distinct clinicopathologic meanings
-
Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwander-Tetri BA, Network NCR. 2011. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 53:810-20
-
(2011)
Hepatology
, vol.53
, pp. 810-820
-
-
Network NCR1
Brunt, E.M.2
Kleiner, D.E.3
Wilson, L.A.4
Belt, P.5
Neuschwander-Tetri, B.A.6
-
48
-
-
79957521377
-
Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality
-
Younossi ZM, Stepanova M, Rafiq N, Makhlouf H, Younoszai Z, et al. 2011. Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality. Hepatology 53:1874-82
-
(2011)
Hepatology
, vol.53
, pp. 1874-1882
-
-
Younossi, Z.M.1
Stepanova, M.2
Rafiq, N.3
Makhlouf, H.4
Younoszai, Z.5
-
49
-
-
33748110788
-
Hepatic histology in obese patients undergoing bariatric surgery
-
Machado M, Marques-Vidal P, Cortez-Pinto H. 2006. Hepatic histology in obese patients undergoing bariatric surgery. J. Hepatol. 45:600-6
-
(2006)
J. Hepatol.
, vol.45
, pp. 600-606
-
-
Machado, M.1
Marques-Vidal, P.2
Cortez-Pinto, H.3
-
50
-
-
84868235041
-
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
-
Bedossa P, Poitou C, Veyrie N, Bouillot JL, Basdevant A, et al. 2012. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology 56:1751-59
-
(2012)
Hepatology
, vol.56
, pp. 1751-1759
-
-
Bedossa, P.1
Poitou, C.2
Veyrie, N.3
Bouillot, J.L.4
Basdevant, A.5
-
51
-
-
79959573040
-
Endpoints and clinical trial design for nonalcoholic steatohepatitis
-
Sanyal AJ, Brunt EM, Kleiner DE, Kowdley KV, Chalasani N, et al. 2011. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology 54:344-53
-
(2011)
Hepatology
, vol.54
, pp. 344-353
-
-
Sanyal, A.J.1
Brunt, E.M.2
Kleiner, D.E.3
Kowdley, K.V.4
Chalasani, N.5
-
52
-
-
84904747070
-
Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease
-
Bedossa P, FLIP Pathol. Consort. 2014. Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease. Hepatology 60:565-75
-
(2014)
Hepatology
, vol.60
, pp. 565-575
-
-
FLIP Pathol. Consort1
Bedossa, P.2
-
53
-
-
84886166367
-
The natural history of NAFLD
-
Ed. GC Farrell, AJ McCulloch, CP Day. Oxford, UK: Wiley-Blackwell
-
Angulo P. 2013. The natural history of NAFLD. In Non-Alcoholic Fatty Liver Disease: A Practical Guide, ed. GC Farrell, AJ McCulloch, CP Day, pp. 37-45. Oxford, UK: Wiley-Blackwell
-
(2013)
Non-Alcoholic Fatty Liver Disease: A Practical Guide
, pp. 37-45
-
-
Angulo, P.1
-
54
-
-
84882906611
-
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
-
Pais R, Charlotte F, Fedchuk L, Bedossa P, Lebray P, et al. 2013. A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver. J. Hepatol. 59:550-56
-
(2013)
J. Hepatol.
, vol.59
, pp. 550-556
-
-
Pais, R.1
Charlotte, F.2
Fedchuk, L.3
Bedossa, P.4
Lebray, P.5
-
55
-
-
84927796763
-
Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
-
McPherson S, Hardy T, Henderson E, Burt AD, Day CP, Anstee QM. 2015. Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. J. Hepatol. 62:1148-55
-
(2015)
J. Hepatol.
, vol.62
, pp. 1148-1155
-
-
McPherson, S.1
Hardy, T.2
Henderson, E.3
Burt, A.D.4
Day, C.P.5
Anstee, Q.M.6
-
56
-
-
75449088414
-
Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
-
Soderberg C, Stal P, Askling J, Glaumann H, Lindberg G, et al. 2010. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology 51:595-602
-
(2010)
Hepatology
, vol.51
, pp. 595-602
-
-
Soderberg, C.1
Stal, P.2
Askling, J.3
Glaumann, H.4
Lindberg, G.5
-
57
-
-
70350626532
-
Final results of a long-term, clinical follow-up in fatty liver patients
-
Dam-Larsen S, Becker U, Franzmann MB, Larsen K, Christoffersen P, Bendtsen F. 2009. Final results of a long-term, clinical follow-up in fatty liver patients. Scand. J. Gastroenterol. 44:1236-43
-
(2009)
Scand. J. Gastroenterol.
, vol.44
, pp. 1236-1243
-
-
Dam-Larsen, S.1
Becker, U.2
Franzmann, M.B.3
Larsen, K.4
Christoffersen, P.5
Bendtsen, F.6
-
58
-
-
79956287499
-
High prevalence of advanced fibrosis in association with the metabolic syndrome in a Belgian prospective cohort of NAFLD patients with elevated ALT. Results of the Belgian NAFLD registry
-
Francque S, De Maeght S, AdlerM, Deltenre P, de Galocsy C, et al. 2011. High prevalence of advanced fibrosis in association with the metabolic syndrome in a Belgian prospective cohort of NAFLD patients with elevated ALT. Results of the Belgian NAFLD registry. Acta Gastro-Enterol. Belg. 74:9-16
-
(2011)
Acta Gastro-Enterol. Belg.
, vol.74
, pp. 9-16
-
-
Francque, S.1
De Maeght, S.2
Adler, M.3
Deltenre, P.4
De Galocsy, C.5
-
59
-
-
84884416525
-
Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease
-
Angulo P, BugianesiE,BjornssonES, CharatcharoenwitthayaP,Mills PR, et al. 2013. Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 145:782-89.e4
-
(2013)
Gastroenterology
, vol.145
, pp. 782e4-789e4
-
-
Angulo, P.1
Bugianesi, E.2
Bjornsson, E.S.3
Charatcharoenwitthaya, P.4
Mills, P.R.5
-
60
-
-
0025178612
-
The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
-
Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. 1990. The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years. Hepatology 11:74-80
-
(1990)
Hepatology
, vol.11
, pp. 74-80
-
-
Powell, E.E.1
Cooksley, W.G.2
Hanson, R.3
Searle, J.4
Halliday, J.W.5
Powell, L.W.6
-
61
-
-
0034116558
-
Liver fibrosis in overweight patients
-
Ratziu V, Giral P, Charlotte F, Bruckert E, Thibault V, et al. 2000. Liver fibrosis in overweight patients. Gastroenterology 118:1117-23
-
(2000)
Gastroenterology
, vol.118
, pp. 1117-1123
-
-
Ratziu, V.1
Giral, P.2
Charlotte, F.3
Bruckert, E.4
Thibault, V.5
-
62
-
-
0141510580
-
The natural history of nonalcoholic fatty liver disease: A clinical histopathological study
-
Harrison SA, Torgerson S, Hayashi PH. 2003. The natural history of nonalcoholic fatty liver disease: A clinical histopathological study. Am. J. Gastroenterol. 98:2042-47
-
(2003)
Am. J. Gastroenterol.
, vol.98
, pp. 2042-2047
-
-
Harrison, S.A.1
Torgerson, S.2
Hayashi, P.H.3
-
63
-
-
0036724436
-
Non-alcoholic steatohepatitis: A common cause of progressive chronic liver injury?
-
Evans CD, Oien KA, MacSween RN, Mills PR. 2002. Non-alcoholic steatohepatitis: A common cause of progressive chronic liver injury? J. Clin. Pathol. 55:689-92
-
(2002)
J. Clin. Pathol.
, vol.55
, pp. 689-692
-
-
Evans, C.D.1
Oien, K.A.2
MacSween, R.N.3
Mills, P.R.4
-
64
-
-
11144351102
-
The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
-
Adams LA, Sanderson S, Lindor KD, Angulo P. 2005. The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies. J. Hepatol. 42:132-38
-
(2005)
J. Hepatol.
, vol.42
, pp. 132-138
-
-
Adams, L.A.1
Sanderson, S.2
Lindor, K.D.3
Angulo, P.4
-
65
-
-
0024336332
-
Nonalcoholic steatohepatitis: A study of 49 patients
-
Lee RG. 1989. Nonalcoholic steatohepatitis: A study of 49 patients. Hum. Pathol. 20:594-98
-
(1989)
Hum. Pathol.
, vol.20
, pp. 594-598
-
-
Lee, R.G.1
-
67
-
-
4644297019
-
Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
-
Fassio E, Alvarez E, DominguezN, Landeira G, Longo C. 2004. Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies. Hepatology 40:820-26
-
(2004)
Hepatology
, vol.40
, pp. 820-826
-
-
Fassio, E.1
Alvarez, E.2
Dominguez, N.3
Landeira, G.4
Longo, C.5
-
68
-
-
84924938800
-
Fibrosis progression in nonalcoholic fatty liver versus nonalcoholic steatohepatitis: A systematic review andmeta-analysis of paired-biopsy studies
-
Singh S, Allen AM, Wang Z, Prokop LJ, MuradMH, Loomba R. 2015. Fibrosis progression in nonalcoholic fatty liver versus nonalcoholic steatohepatitis: A systematic review andmeta-analysis of paired-biopsy studies. Clin. Gastroenterol. Hepatol. 13:643-54.e9
-
(2015)
Clin. Gastroenterol. Hepatol.
, vol.13
, pp. 643e9-654e9
-
-
Singh, S.1
Allen, A.M.2
Wang, Z.3
Prokop, L.J.4
Murad, M.H.5
Loomba, R.6
-
69
-
-
77955625142
-
Population-based risk factors and resource utilization for HCC: US perspective
-
Sanyal A, Poklepovic A, Moyneur E, Barghout V. 2010. Population-based risk factors and resource utilization for HCC: US perspective. Curr. Med. Res. Opin. 26:2183-91
-
(2010)
Curr. Med. Res. Opin.
, vol.26
, pp. 2183-2191
-
-
Sanyal, A.1
Poklepovic, A.2
Moyneur, E.3
Barghout, V.4
-
70
-
-
33646413672
-
The global health burden of infection-associated cancers in the year 2002
-
Parkin DM. 2006. The global health burden of infection-associated cancers in the year 2002. Int. J. Cancer 118:3030-44
-
(2006)
Int. J. Cancer
, vol.118
, pp. 3030-3044
-
-
Parkin, D.M.1
-
71
-
-
77951456114
-
Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
-
Starley BQ, Calcagno CJ, Harrison SA. 2010. Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection. Hepatology 51:1820-32
-
(2010)
Hepatology
, vol.51
, pp. 1820-1832
-
-
Starley, B.Q.1
Calcagno, C.J.2
Harrison, S.A.3
-
72
-
-
58849090967
-
Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
-
Hashimoto E, Yatsuji S, Tobari M, Taniai M, Torii N, et al. 2009. Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. J. Gastroenterol. 44(Suppl. 19):89-95
-
(2009)
J. Gastroenterol.
, vol.44
, pp. 89-95
-
-
Hashimoto, E.1
Yatsuji, S.2
Tobari, M.3
Taniai, M.4
Torii, N.5
-
73
-
-
77952730428
-
The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
-
Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN. 2010. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 51:1972-78
-
(2010)
Hepatology
, vol.51
, pp. 1972-1978
-
-
Ascha, M.S.1
Hanouneh, I.A.2
Lopez, R.3
Tamimi, T.A.4
Feldstein, A.F.5
Zein, N.N.6
-
74
-
-
33746485735
-
Natural history of Japanese patients with non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC)
-
Yatsuji S, Hashimoto E. 2006. [Natural history of Japanese patients with non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC)]. Nihon Rinsho. Jpn. J. Clin. Med. 64:1173-79
-
(2006)
Nihon Rinsho. Jpn. J. Clin. Med.
, vol.64
, pp. 1173-1179
-
-
Yatsuji, S.1
Hashimoto, E.2
-
75
-
-
33645963121
-
Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
-
Sanyal AJ, Banas C, Sargeant C, Luketic VA, Sterling RK, et al. 2006. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 43:682-89
-
(2006)
Hepatology
, vol.43
, pp. 682-689
-
-
Sanyal, A.J.1
Banas, C.2
Sargeant, C.3
Luketic, V.A.4
Sterling, R.K.5
-
76
-
-
79960549297
-
The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study
-
Bhala N, Angulo P, van der Poorten D, Lee E, Hui JM, et al. 2011. The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology 54:1208-16
-
(2011)
Hepatology
, vol.54
, pp. 1208-1216
-
-
Bhala, N.1
Angulo, P.2
Van Der Poorten, D.3
Lee, E.4
Hui, J.M.5
-
77
-
-
0043268063
-
Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
-
Hui JM, Kench JG, Chitturi S, Sud A, Farrell GC, et al. 2003. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology 38:420-27
-
(2003)
Hepatology
, vol.38
, pp. 420-427
-
-
Hui, J.M.1
Kench, J.G.2
Chitturi, S.3
Sud, A.4
Farrell, G.C.5
-
78
-
-
84863772732
-
Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma
-
YasuiK,Hashimoto E, TokushigeK,Koike K, Shima T, et al. 2012. Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma. Hepatol. Res. 42:767-73
-
(2012)
Hepatol. Res.
, vol.42
, pp. 767-773
-
-
Yasui, K.1
Hashimoto, E.2
Tokushige, K.3
Koike, K.4
Shima, T.5
-
79
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
El-Serag HB, Rudolph KL. 2007. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132:2557-76
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
80
-
-
0037464510
-
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U. S. Adults
-
Calle EE, RodriguezC,Walker-Thurmond K,ThunMJ. 2003. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 348:1625-38
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1625-1638
-
-
Calle, E.E.1
Rodriguez, C.2
Walker-Thurmond, K.3
Thun, M.J.4
-
81
-
-
34948867745
-
Overweight, obesity and risk of liver cancer: Ameta-analysis of cohort studies
-
Larsson SC, Wolk A. 2007. Overweight, obesity and risk of liver cancer: ameta-analysis of cohort studies. Br. J. Cancer 97:1005-8
-
(2007)
Br. J. Cancer
, vol.97
, pp. 1005-1008
-
-
Larsson, S.C.1
Wolk, A.2
-
82
-
-
0036288123
-
Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis?
-
Nair S, Mason A, Eason J, Loss G, Perrillo RP. 2002. Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis? Hepatology 36:150-55
-
(2002)
Hepatology
, vol.36
, pp. 150-155
-
-
Nair, S.1
Mason, A.2
Eason, J.3
Loss, G.4
Perrillo, R.P.5
-
83
-
-
0842321807
-
Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
-
El-Serag HB, Tran T, Everhart JE. 2004. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 126:460-68
-
(2004)
Gastroenterology
, vol.126
, pp. 460-468
-
-
El-Serag, H.B.1
Tran, T.2
Everhart, J.E.3
-
84
-
-
33746514438
-
Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis
-
N'Kontchou G, Paries J, Htar MT, Ganne-Carrie N, Costentin L, et al. 2006. Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis. Clin. Gastroenterol. Hepatol. 4:1062-68
-
(2006)
Clin. Gastroenterol. Hepatol.
, vol.4
, pp. 1062-1068
-
-
N'Kontchou, G.1
Paries, J.2
Htar, M.T.3
Ganne-Carrie, N.4
Costentin, L.5
-
85
-
-
79955033727
-
Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma
-
quiz e50
-
Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, et al. 2011. Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Clin. Gastroenterol. Hepatol. 9:428-33; quiz e50
-
(2011)
Clin. Gastroenterol. Hepatol.
, vol.9
, pp. 428-433
-
-
Yasui, K.1
Hashimoto, E.2
Komorizono, Y.3
Koike, K.4
Arii, S.5
-
86
-
-
84890562275
-
Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team
-
Dyson J, Jaques B,ChattopadyhayD, Lochan R,Graham J, et al. 2014. Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team. J. Hepatol. 60:110-17
-
(2014)
J. Hepatol.
, vol.60
, pp. 110-117
-
-
Dyson, J.1
Jaques, B.2
Chattopadyhay, D.3
Lochan, R.4
Graham, J.5
-
87
-
-
84929629712
-
Nonalcoholic steatohepatitis: A search for factual animal models
-
Sanches SC, Ramalho LN, AugustoMJ, da Silva DM, Ramalho FS. 2015. Nonalcoholic steatohepatitis: A search for factual animal models. Biomed. Res. Int. 2015:574832
-
(2015)
Biomed. Res. Int.
, vol.2015
, pp. 574832
-
-
Sanches, S.C.1
Ramalho, L.N.2
Augusto, M.J.3
Da Silva, D.M.4
Ramalho, F.S.5
-
88
-
-
0010113419
-
Hereditary diabetes in genetically obese mice
-
Mayer J, BatesMW, DickieMM.1951. Hereditary diabetes in genetically obese mice. Science 113:746-47
-
(1951)
Science
, vol.113
, pp. 746-747
-
-
Mayer, J.1
Bates, M.W.2
Dickie, M.M.3
-
89
-
-
0037621952
-
Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury
-
Leclercq IA, Field J, Farrell GC. 2003. Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. Gastroenterology 124:1451-64
-
(2003)
Gastroenterology
, vol.124
, pp. 1451-1464
-
-
Leclercq, I.A.1
Field, J.2
Farrell, G.C.3
-
90
-
-
0347364706
-
Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis?
-
Chalasani N, Crabb DW, Cummings OW, Kwo PY, Asghar A, et al. 2003. Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis? Am. J. Gastroenterol. 98:2771-76
-
(2003)
Am. J. Gastroenterol.
, vol.98
, pp. 2771-2776
-
-
Chalasani, N.1
Crabb, D.W.2
Cummings, O.W.3
Kwo, P.Y.4
Asghar, A.5
-
91
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
-
Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, et al. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-95
-
(1996)
Cell
, vol.84
, pp. 491-495
-
-
Chen, H.1
Charlat, O.2
Tartaglia, L.A.3
Woolf, E.A.4
Weng, X.5
-
92
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE. 1998. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273:13375-78
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
93
-
-
85047694402
-
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
-
Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, et al. 2004. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Investig. 113:1774-83
-
(2004)
J. Clin. Investig.
, vol.113
, pp. 1774-1783
-
-
Horie, Y.1
Suzuki, A.2
Kataoka, E.3
Sasaki, T.4
Hamada, K.5
-
94
-
-
57349137214
-
SevereNAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
-
Tetri LH, Basaranoglu M, Brunt EM, Yerian LM,Neuschwander-Tetri BA. 2008. SevereNAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am. J. Physiol. Gastrointest. Liver Physiol. 295:G987-95
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.295
, pp. G987-G995
-
-
Tetri, L.H.1
Basaranoglu, M.2
Brunt, E.M.3
Yerian, L.M.4
Neuschwander-Tetri, B.A.5
-
95
-
-
77956634470
-
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
-
Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, et al. 2010. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 52:934-44
-
(2010)
Hepatology
, vol.52
, pp. 934-944
-
-
Kohli, R.1
Kirby, M.2
Xanthakos, S.A.3
Softic, S.4
Feldstein, A.E.5
-
96
-
-
36348935003
-
Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
-
Matsuzawa N, Takamura T, Kurita S, Misu H, Ota T, et al. 2007. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 46:1392-403
-
(2007)
Hepatology
, vol.46
, pp. 1392-1403
-
-
Matsuzawa, N.1
Takamura, T.2
Kurita, S.3
Misu, H.4
Ota, T.5
-
97
-
-
80053612479
-
Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis
-
1403.e1-5
-
Van Rooyen DM, Larter CZ, Haigh WG, Yeh MM, Ioannou G, et al. 2011. Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis. Gastroenterology 141:1393-403, 1403.e1-5
-
(2011)
Gastroenterology
, vol.141
, pp. 1393-1403
-
-
Van Rooyen, D.M.1
Larter, C.Z.2
Haigh, W.G.3
Yeh, M.M.4
Ioannou, G.5
-
98
-
-
7044264899
-
Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease
-
Gao D, Wei C, Chen L, Huang J, Yang S, Diehl AM. 2004. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. Am. J. Physiol.Gastrointest. Liver Physiol. 287:G1070-77
-
(2004)
Am. J. Physiol.Gastrointest. Liver Physiol.
, vol.287
, pp. G1070-G1077
-
-
Gao, D.1
Wei, C.2
Chen, L.3
Huang, J.4
Yang, S.5
Diehl, A.M.6
-
99
-
-
0344010170
-
Rodent nutritional model of non-alcoholic steatohepatitis: Species, strain and sex difference studies
-
Kirsch R, Clarkson V, Shephard EG, Marais DA, Jaffer MA, et al. 2003. Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies. J. Gastroenterol. Hepatol. 18:1272-82
-
(2003)
J. Gastroenterol. Hepatol.
, vol.18
, pp. 1272-1282
-
-
Kirsch, R.1
Clarkson, V.2
Shephard, E.G.3
Marais, D.A.4
Jaffer, M.A.5
-
100
-
-
0029829455
-
Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
-
WeltmanMD, Farrell GC, Liddle C. 1996. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 111:1645-53
-
(1996)
Gastroenterology
, vol.111
, pp. 1645-1653
-
-
Weltman, M.D.1
Farrell, G.C.2
Liddle, C.3
-
101
-
-
0036125222
-
Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet
-
Denda A, KitayamaW, Kishida H, Murata N, Tsutsumi M, et al. 2002. Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet. Jpn. J. Cancer Res. 93:125-32
-
(2002)
Jpn. J. Cancer Res.
, vol.93
, pp. 125-132
-
-
Denda, A.1
Kitayama, W.2
Kishida, H.3
Murata, N.4
Tsutsumi, M.5
-
102
-
-
84901366784
-
HCC development is associated to peripheral insulin resistance in a mouse model of NASH
-
De Minicis S, Agostinelli L, Rychlicki C, Sorice GP, Saccomanno S, et al. 2014. HCC development is associated to peripheral insulin resistance in a mouse model of NASH. PLOS ONE 9:e97136
-
(2014)
PLOS ONE
, vol.9
, pp. e97136
-
-
De Minicis, S.1
Agostinelli, L.2
Rychlicki, C.3
Sorice, G.P.4
Saccomanno, S.5
-
103
-
-
33644955272
-
Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
-
Anstee QM, Goldin RD. 2006. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int. J. Exp. Pathol. 87:1-16
-
(2006)
Int. J. Exp. Pathol.
, vol.87
, pp. 1-16
-
-
Anstee, Q.M.1
Goldin, R.D.2
-
104
-
-
84878930738
-
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
-
Anstee QM, Targher G, Day CP. 2013. Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat. Rev. 10:330-44
-
(2013)
Nat. Rev.
, vol.10
, pp. 330-344
-
-
Anstee, Q.M.1
Targher, G.2
Day, C.P.3
-
105
-
-
77953868236
-
Lipid-induced insulin resistance: Unravelling the mechanism
-
Samuel VT, Petersen KF, Shulman GI. 2010. Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375:2267-77
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.F.2
Shulman, G.I.3
-
107
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. 2010. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11:467-78
-
(2010)
Cell Metab.
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
108
-
-
34250356015
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
-
Yamaguchi K, Yang L,McCall S, Huang J, Yu XX, et al. 2007. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45:1366-74
-
(2007)
Hepatology
, vol.45
, pp. 1366-1374
-
-
Yamaguchi, K.1
Yang, L.2
McCall, S.3
Huang, J.4
Yu, X.X.5
-
109
-
-
33644524120
-
Apoptosis and necrosis in the liver: A tale of two deaths?
-
MalhiH,Gores GJ, Lemasters JJ. 2006. Apoptosis and necrosis in the liver: A tale of two deaths? Hepatology 43:S31-44
-
(2006)
Hepatology
, vol.43
, pp. S31-44
-
-
Malhi, H.1
Gores, G.J.2
Lemasters, J.J.3
-
110
-
-
63049134573
-
Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression
-
Farrell GC, Larter CZ, Hou JY, Zhang RH, Yeh MM, et al. 2009. Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. J. Gastroenterol. Hepatol. 24:443-52
-
(2009)
J. Gastroenterol. Hepatol.
, vol.24
, pp. 443-452
-
-
Farrell, G.C.1
Larter, C.Z.2
Hou, J.Y.3
Zhang, R.H.4
Yeh, M.M.5
-
111
-
-
77955852465
-
Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis
-
Anstee QM, Concas D, Kudo H, Levene A, Pollard J, et al. 2010. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J. Hepatol. 53:542-50
-
(2010)
J. Hepatol.
, vol.53
, pp. 542-550
-
-
Anstee, Q.M.1
Concas, D.2
Kudo, H.3
Levene, A.4
Pollard, J.5
-
112
-
-
33847363203
-
Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
-
Iredale JP. 2007. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Investig. 117:539-48
-
(2007)
J. Clin. Investig.
, vol.117
, pp. 539-548
-
-
Iredale, J.P.1
-
114
-
-
0036906508
-
Lipoprotein lipase: Genetics, lipid uptake, and regulation
-
Merkel M, Eckel RH, Goldberg IJ. 2002. Lipoprotein lipase: genetics, lipid uptake, and regulation. J. Lipid Res. 43:1997-2006
-
(2002)
J. Lipid Res.
, vol.43
, pp. 1997-2006
-
-
Merkel, M.1
Eckel, R.H.2
Goldberg, I.J.3
-
115
-
-
84864090834
-
Mechanisms of simple hepatic steatosis: Not so simple after all
-
Matherly SC, Puri P. 2012. Mechanisms of simple hepatic steatosis: not so simple after all. Clin. Liver Dis. 16:505-24
-
(2012)
Clin. Liver Dis.
, vol.16
, pp. 505-524
-
-
Matherly, S.C.1
Puri, P.2
-
116
-
-
33847006599
-
The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
-
Cha JY, Repa JJ. 2007. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 282:743-51
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 743-751
-
-
Cha, J.Y.1
Repa, J.J.2
-
117
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, et al. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev. 14:2819-30
-
(2000)
Genes Dev.
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.M.5
-
118
-
-
33846208252
-
The nuclear receptor LXR is a glucose sensor
-
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, et al. 2007. The nuclear receptor LXR is a glucose sensor. Nature 445:219-23
-
(2007)
Nature
, vol.445
, pp. 219-223
-
-
Mitro, N.1
Mak, P.A.2
Vargas, L.3
Godio, C.4
Hampton, E.5
-
119
-
-
79961239382
-
Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley interdiscip
-
Vacca M, DegirolamoC,Mariani-Costantini R, PalascianoG,Moschetta A. 2011. Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley Interdiscip. Rev. Syst. Biol. Med. 3:562-87
-
(2011)
Rev. Syst. Biol. Med.
, vol.3
, pp. 562-587
-
-
Vacca, M.1
Degirolamo, C.2
Mariani-Costantini, R.3
Palasciano, G.4
Moschetta, A.5
-
120
-
-
77955690182
-
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
-
Neuschwander-Tetri BA. 2010. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites. Hepatology 52:774-88
-
(2010)
Hepatology
, vol.52
, pp. 774-788
-
-
Neuschwander-Tetri, B.A.1
-
121
-
-
0033609775
-
Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription
-
Sato R, Miyamoto W, Inoue J, TeradaT, Imanaka T, MaedaM. 1999. Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. J. Biol. Chem. 274:24714-20
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24714-24720
-
-
Sato, R.1
Miyamoto, W.2
Inoue, J.3
Terada, T.4
Imanaka, T.5
Maeda, M.6
-
122
-
-
56149127703
-
Regulatable fatty acid transportmechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome
-
Berk PD. 2008. Regulatable fatty acid transportmechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome. Hepatology 48:1362-76
-
(2008)
Hepatology
, vol.48
, pp. 1362-1376
-
-
Berk, P.D.1
-
123
-
-
33645994830
-
Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity
-
Hubbard B, Doege H, Punreddy S, Wu H, Huang X, et al. 2006. Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology 130:1259-69
-
(2006)
Gastroenterology
, vol.130
, pp. 1259-1269
-
-
Hubbard, B.1
Doege, H.2
Punreddy, S.3
Wu, H.4
Huang, X.5
-
124
-
-
52049117445
-
Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia
-
DoegeH,Grimm D, Falcon A,Tsang B, StormTA, et al. 2008. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. J. Biol. Chem. 283:22186-92
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22186-22192
-
-
Doege, H.1
Grimm, D.2
Falcon, A.3
Tsang, B.4
Storm, T.A.5
-
126
-
-
45849118669
-
Gene expression in humanNAFLD
-
GrecoD,Kotronen A,Westerbacka J, PuigO, Arkkila P, et al. 2008. Gene expression in humanNAFLD. Am. J. Physiol. Gastrointest. Liver Physiol. 294:G1281-87
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.294
, pp. G1281-G1287
-
-
Greco, D.1
Kotronen, A.2
Westerbacka, J.3
Puig, O.4
Arkkila, P.5
-
127
-
-
77954363354
-
Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis
-
Bechmann LP, Gieseler RK, Sowa JP, Kahraman A, Erhard J, et al. 2010. Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. Liver Int. 30:850-59
-
(2010)
Liver Int.
, vol.30
, pp. 850-859
-
-
Bechmann, L.P.1
Gieseler, R.K.2
Sowa, J.P.3
Kahraman, A.4
Erhard, J.5
-
128
-
-
0031043030
-
Themitochondrial carnitine palmitoyltransferase system. from concept to molecular analysis
-
McGarry JD, BrownNF. 1997. Themitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244:1-14
-
(1997)
Eur. J. Biochem.
, vol.244
, pp. 1-14
-
-
McGarry, J.D.1
Brown, N.F.2
-
129
-
-
79957970349
-
Comparative gene expression profiles induced by PPARγand PPARα/γagonists in rat hepatocytes
-
Rogue A, Renaud MP, Claude N, Guillouzo A, Spire C. 2011. Comparative gene expression profiles induced by PPARγand PPARα/γagonists in rat hepatocytes. Toxicol. Appl. Pharmacol. 254:18-31
-
(2011)
Toxicol. Appl. Pharmacol.
, vol.254
, pp. 18-31
-
-
Rogue, A.1
Renaud, M.P.2
Claude, N.3
Guillouzo, A.4
Spire, C.5
-
130
-
-
0035658444
-
Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis
-
Reddy JK. 2001. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G1333-39
-
(2001)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.281
, pp. G1333-G1339
-
-
Reddy, J.K.1
-
131
-
-
43449105323
-
Liver lipid metabolism
-
Nguyen P, Leray V, DiezM, Serisier S, Le Bloc'h J, et al. 2008. Liver lipid metabolism. J. Anim. Physiol. Anim. Nutr. 92:272-83
-
(2008)
J. Anim. Physiol. Anim. Nutr.
, vol.92
, pp. 272-283
-
-
Nguyen, P.1
Leray, V.2
Diez, M.3
Serisier, S.4
Le Bloc'h, J.5
-
132
-
-
14544289119
-
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): Two key regulators of glucose metabolism and lipid synthesis in liver
-
Dentin R, Girard J, Postic C. 2005. Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie 87:81-86
-
(2005)
Biochimie
, vol.87
, pp. 81-86
-
-
Dentin, R.1
Girard, J.2
Postic, C.3
-
133
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. 2005. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Investig. 115:1343-51
-
(2005)
J. Clin. Investig.
, vol.115
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
134
-
-
33847746323
-
A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production
-
Dries DR, Gallegos LL, Newton AC. 2007. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J. Biol. Chem. 282:826-30
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 826-830
-
-
Dries, D.R.1
Gallegos, L.L.2
Newton, A.C.3
-
135
-
-
33847404482
-
Inhibition of protein kinase Cϵ prevents hepatic insulin resistance in nonalcoholic fatty liver disease
-
Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, et al. 2007. Inhibition of protein kinase Cϵ prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J. Clin. Investig. 117:739-45
-
(2007)
J. Clin. Investig.
, vol.117
, pp. 739-745
-
-
Samuel, V.T.1
Liu, Z.X.2
Wang, A.3
Beddow, S.A.4
Geisler, J.G.5
-
136
-
-
80053627289
-
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
-
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, et al. 2011. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. PNAS 108:16381-85
-
(2011)
PNAS
, vol.108
, pp. 16381-16385
-
-
Kumashiro, N.1
Erion, D.M.2
Zhang, D.3
Kahn, M.4
Beddow, S.A.5
-
138
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G, Das M, Mora A, Zhang Z, Jun JY, et al. 2008. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322:1539-43
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
-
139
-
-
17844393870
-
Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): Implication of macrophages resident in the at
-
Bruun JM, Lihn AS, Pedersen SB, Richelsen B. 2005. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J. Clin. Endocrinol. Metab. 90:2282-89
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 2282-2289
-
-
Bruun, J.M.1
Lihn, A.S.2
Pedersen, S.B.3
Richelsen, B.4
-
140
-
-
1542570269
-
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine
-
Yamauchi T, Hara K, Kubota N, Terauchi Y, Tobe K, et al. 2003. Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr. Drug Targets Immune Endocr. Metab. Disord. 3:243-54
-
(2003)
Curr. Drug Targets Immune Endocr. Metab. Disord.
, vol.3
, pp. 243-254
-
-
Yamauchi, T.1
Hara, K.2
Kubota, N.3
Terauchi, Y.4
Tobe, K.5
-
141
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. 2006. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Investig. 116:1784-92
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
Tobe, K.6
-
142
-
-
0041302377
-
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
-
Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. 2003. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Investig. 112:91-100
-
(2003)
J. Clin. Investig.
, vol.112
, pp. 91-100
-
-
Xu, A.1
Wang, Y.2
Keshaw, H.3
Xu, L.Y.4
Lam, K.S.5
Cooper, G.J.6
-
143
-
-
13444274359
-
Plasma adiponectin decrease in women with nonalcoholic fatty liver
-
Matsubara M. 2004. Plasma adiponectin decrease in women with nonalcoholic fatty liver. Endocr. J. 51:587-93
-
(2004)
Endocr. J.
, vol.51
, pp. 587-593
-
-
Matsubara, M.1
-
144
-
-
33645884425
-
Liver adenosine monophosphateactivated kinase-α2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
-
Andreelli F, Foretz M, Knauf C, Cani PD, Perrin C, et al. 2006. Liver adenosine monophosphateactivated kinase-α2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology 147:2432-41
-
(2006)
Endocrinology
, vol.147
, pp. 2432-2441
-
-
Andreelli, F.1
Foretz, M.2
Knauf, C.3
Cani, P.D.4
Perrin, C.5
-
147
-
-
0028836714
-
Isolation of proteins that interact specifically with the retinoid X receptor: Two novel orphan receptors
-
Seol W, Choi HS, Moore DD. 1995. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol. Endocrinol. 9:72-85
-
(1995)
Mol. Endocrinol.
, vol.9
, pp. 72-85
-
-
Seol, W.1
Choi, H.S.2
Moore, D.D.3
-
148
-
-
0029046931
-
Identification of a nuclear receptor that is activated by farnesol metabolites
-
Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, et al. 1995. Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81:687-93
-
(1995)
Cell
, vol.81
, pp. 687-693
-
-
Forman, B.M.1
Goode, E.2
Chen, J.3
Oro, A.E.4
Bradley, D.J.5
-
149
-
-
84878972563
-
FarnesoidXreceptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes
-
Caron S, Huaman SamanezC,Dehondt H, Ploton M, BriandO, et al. 2013. FarnesoidXreceptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. Mol. Cell. Biol. 33:2202-11
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 2202-2211
-
-
Caron, S.1
Huaman Samanez, C.2
Dehondt, H.3
Ploton, M.4
Briand, O.5
-
150
-
-
58249110568
-
Role of bile acids and bile acid receptors in metabolic regulation
-
Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. 2009. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89:147-91
-
(2009)
Physiol. Rev.
, vol.89
, pp. 147-191
-
-
Lefebvre, P.1
Cariou, B.2
Lien, F.3
Kuipers, F.4
Staels, B.5
-
151
-
-
0037315190
-
Bile acids induce the expression of the human peroxisome proliferator-activated receptorαgene via activation of the farnesoid X receptor
-
Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. 2003. Bile acids induce the expression of the human peroxisome proliferator-activated receptorαgene via activation of the farnesoid X receptor. Mol. Endocrinol. 17:259-72
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 259-272
-
-
Pineda Torra, I.1
Claudel, T.2
Duval, C.3
Kosykh, V.4
Fruchart, J.C.5
Staels, B.6
-
152
-
-
0042666932
-
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
-
Claudel T, Inoue Y, BarbierO,Duran-Sandoval D, Kosykh V, et al. 2003. Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology 125:544-55
-
(2003)
Gastroenterology
, vol.125
, pp. 544-555
-
-
Claudel, T.1
Inoue, Y.2
Barbier, O.3
Duran-Sandoval, D.4
Kosykh, V.5
-
153
-
-
84896400380
-
Failing FXR expression in the liver links aging to hepatic steatosis
-
Lefebvre P, Staels B. 2014. Failing FXR expression in the liver links aging to hepatic steatosis. J. Hepatol. 60:689-90
-
(2014)
J. Hepatol.
, vol.60
, pp. 689-690
-
-
Lefebvre, P.1
Staels, B.2
-
154
-
-
80053449479
-
Genetic modifiers of non-alcoholic fatty liver disease progression
-
Anstee QM, Daly AK, Day CP. 2011. Genetic modifiers of non-alcoholic fatty liver disease progression. Biochim. Biophys. Acta 1812:1557-66
-
(2011)
Biochim. Biophys. Acta
, vol.1812
, pp. 1557-1566
-
-
Anstee, Q.M.1
Daly, A.K.2
Day, C.P.3
-
155
-
-
65549136260
-
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: Role of stearoyl-CoA desaturase
-
Li ZZ, Berk M, McIntyre TM, Feldstein AE. 2009. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J. Biol. Chem. 284:5637-44
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 5637-5644
-
-
Li, Z.Z.1
Berk, M.2
McIntyre, T.M.3
Feldstein, A.E.4
-
156
-
-
33747626511
-
Mitochondrial free cholesterol loading sensitizes to TNF-and Fas-mediated steatohepatitis
-
Mari M, Caballero F, Colell A, Morales A, Caballeria J, et al. 2006. Mitochondrial free cholesterol loading sensitizes to TNF-and Fas-mediated steatohepatitis. Cell Metab. 4:185-98
-
(2006)
Cell Metab.
, vol.4
, pp. 185-198
-
-
Mari, M.1
Caballero, F.2
Colell, A.3
Morales, A.4
Caballeria, J.5
-
157
-
-
36349024819
-
A lipidomic analysis of nonalcoholic fatty liver disease
-
Puri P, Baillie RA,Wiest MM, Mirshahi F, Choudhury J, et al. 2007. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 46:1081-90
-
(2007)
Hepatology
, vol.46
, pp. 1081-1090
-
-
Puri, P.1
Baillie, R.A.2
Wiest, M.M.3
Mirshahi, F.4
Choudhury, J.5
-
159
-
-
33749370739
-
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
-
Dentin R. 2006. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes 55:2159-70
-
(2006)
Diabetes
, vol.55
, pp. 2159-2170
-
-
Dentin, R.1
-
160
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance andmitochondrial abnormalities
-
Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, et al. 2001. Nonalcoholic steatohepatitis: association of insulin resistance andmitochondrial abnormalities. Gastroenterology 120:1183-92
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
-
161
-
-
0242438087
-
Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis
-
George J, Pera N, Phung N, Leclercq I, Yun Hou J, Farrell G. 2003. Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. J. Hepatol. 39:756-64
-
(2003)
J. Hepatol.
, vol.39
, pp. 756-764
-
-
George, J.1
Pera, N.2
Phung, N.3
Leclercq, I.4
Yun Hou, J.5
Farrell, G.6
-
162
-
-
50249116184
-
The endoplasmic reticulum stress response in immunity and autoimmunity
-
Todd DJ, Lee AH, Glimcher LH. 2008. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat. Rev. Immunol. 8:663-74
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 663-674
-
-
Todd, D.J.1
Lee, A.H.2
Glimcher, L.H.3
-
163
-
-
38649124615
-
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
-
Puri P, Mirshahi F, Cheung O, Natarajan R,Maher JW, et al. 2008. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134:568-76
-
(2008)
Gastroenterology
, vol.134
, pp. 568-576
-
-
Puri, P.1
Mirshahi, F.2
Cheung, O.3
Natarajan, R.4
Maher, J.W.5
-
164
-
-
78049522194
-
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
-
Tilg H, Moschen AR. 2010. Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis. Hepatology 52:1836-46
-
(2010)
Hepatology
, vol.52
, pp. 1836-1846
-
-
Tilg, H.1
Moschen, A.R.2
-
165
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS. 2010. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140:900-17
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
166
-
-
33745828301
-
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
-
WeiY,WangD,Topczewski F, Pagliassotti MJ. 2006. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 291:E275-81
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
, pp. E275-E281
-
-
Wei, Y.1
Wang, D.2
Topczewski, F.3
Pagliassotti, M.J.4
-
167
-
-
34547889101
-
Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells
-
Wei Y,Wang D, Pagliassotti MJ. 2007. Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells. Mol. Cell. Biochem. 303:105-13
-
(2007)
Mol. Cell. Biochem.
, vol.303
, pp. 105-113
-
-
Wei, Y.1
Wang, D.2
Pagliassotti, M.J.3
-
168
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:135-45
-
(2001)
Nat. Rev. Immunol.
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
169
-
-
34548272744
-
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
-
Rivera CA, Adegboyega P, van RooijenN,Tagalicud A, Allman M, Wallace M. 2007. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 47:571-79
-
(2007)
J. Hepatol.
, vol.47
, pp. 571-579
-
-
Rivera, C.A.1
Adegboyega, P.2
Van Rooijen, N.3
Tagalicud, A.4
Allman, M.5
Wallace, M.6
-
170
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, et al. 2007. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56:1761-72
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
-
171
-
-
0001513966
-
Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
-
Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. 1997. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. PNAS 94:2557-62
-
(1997)
PNAS
, vol.94
, pp. 2557-2562
-
-
Yang, S.Q.1
Lin, H.Z.2
Lane, M.D.3
Clemens, M.4
Diehl, A.M.5
-
172
-
-
54449092214
-
The critical role of tolllike receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
-
Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, et al. 2008. The critical role of tolllike receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 48:1224-31
-
(2008)
Hepatology
, vol.48
, pp. 1224-1231
-
-
Hritz, I.1
Mandrekar, P.2
Velayudham, A.3
Catalano, D.4
Dolganiuc, A.5
-
173
-
-
77953891627
-
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1βin mice
-
Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, et al. 2010. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1βin mice. Gastroenterology 139:323-34.e7
-
(2010)
Gastroenterology
, vol.139
, pp. 323e7-334e7
-
-
Miura, K.1
Kodama, Y.2
Inokuchi, S.3
Schnabl, B.4
Aoyama, T.5
-
174
-
-
79251600358
-
Type i interferons protect from Tolllike receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice
-
Petrasek J, Dolganiuc A, Csak T, Kurt-Jones EA, Szabo G. 2011. Type I interferons protect from Tolllike receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice. Gastroenterology 140:697-708.e4
-
(2011)
Gastroenterology
, vol.140
, pp. 697e4-708e4
-
-
Petrasek, J.1
Dolganiuc, A.2
Csak, T.3
Kurt-Jones, E.A.4
Szabo, G.5
-
175
-
-
84873289589
-
Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice
-
MiuraK, YangL, van RooijenN, Brenner DA, OhnishiH, Seki E. 2013. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology 57:577-89
-
(2013)
Hepatology
, vol.57
, pp. 577-589
-
-
Miura, K.1
Yang, L.2
Van Rooijen, N.3
Brenner, D.A.4
Ohnishi, H.5
Seki, E.6
-
176
-
-
77952688386
-
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
-
Rivera CA, Gaskin L, Allman M, Pang J, Brady K, et al. 2010. Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. BMC Gastroenterol. 10:52
-
(2010)
BMC Gastroenterol.
, vol.10
, pp. 52
-
-
Rivera, C.A.1
Gaskin, L.2
Allman, M.3
Pang, J.4
Brady, K.5
-
177
-
-
0042165989
-
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
-
Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, et al. 2003. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125:437-43
-
(2003)
Gastroenterology
, vol.125
, pp. 437-443
-
-
Feldstein, A.E.1
Canbay, A.2
Angulo, P.3
Taniai, M.4
Burgart, L.J.5
-
178
-
-
34547193134
-
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
-
Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ. 2007. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 56:1124-31
-
(2007)
Gut
, vol.56
, pp. 1124-1131
-
-
Malhi, H.1
Barreyro, F.J.2
Isomoto, H.3
Bronk, S.F.4
Gores, G.J.5
-
179
-
-
0035183475
-
Gene expression of tumor necrosis factor αand TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
-
Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, et al. 2001. Gene expression of tumor necrosis factor αand TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 34:1158-63
-
(2001)
Hepatology
, vol.34
, pp. 1158-1163
-
-
Crespo, J.1
Cayon, A.2
Fernandez-Gil, P.3
Hernandez-Guerra, M.4
Mayorga, M.5
-
181
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-αexpression via a lysosomal pathway
-
Feldstein AE, WerneburgNW,CanbayA,Guicciardi ME,Bronk SF, et al. 2004. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-αexpression via a lysosomal pathway. Hepatology 40:185-94
-
(2004)
Hepatology
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
Guicciardi, M.E.4
Bronk, S.F.5
-
182
-
-
43949108922
-
The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity
-
Li Z, Berk M, McIntyre TM, Gores GJ, Feldstein AE. 2008. The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology 47:1495-503
-
(2008)
Hepatology
, vol.47
, pp. 1495-1503
-
-
Li, Z.1
Berk, M.2
McIntyre, T.M.3
Gores, G.J.4
Feldstein, A.E.5
-
183
-
-
33646891970
-
Bax inhibition protects against free fatty acid-induced lysosomal permeabilization
-
Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. 2006. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am. J. Physiol. Gastrointest. Liver Physiol. 290:G1339-46
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.290
, pp. G1339-G1346
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Li, Z.3
Bronk, S.F.4
Gores, G.J.5
-
184
-
-
33745904468
-
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
-
Wieckowska A, ZeinNN,Yerian LM,LopezAR, McCullough AJ, Feldstein AE. 2006. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44:27-33
-
(2006)
Hepatology
, vol.44
, pp. 27-33
-
-
Wieckowska, A.1
Zein, N.N.2
Yerian, L.M.3
Lopez, A.R.4
McCullough, A.J.5
Feldstein, A.E.6
-
185
-
-
72949123737
-
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
-
Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, et al. 2009. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology 50:1421-30
-
(2009)
Hepatology
, vol.50
, pp. 1421-1430
-
-
Witek, R.P.1
Stone, W.C.2
Karaca, F.G.3
Syn, W.K.4
Pereira, T.A.5
-
187
-
-
84905239992
-
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis
-
Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, et al. 2014. A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. EMBO Mol. Med. 6:1062-74
-
(2014)
EMBO Mol. Med.
, vol.6
, pp. 1062-1074
-
-
Gautheron, J.1
Vucur, M.2
Reisinger, F.3
Cardenas, D.V.4
Roderburg, C.5
-
188
-
-
84867176929
-
IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
-
Petrasek J, Bala S, Csak T, Lippai D, Kodys K, et al. 2012. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J. Clin. Investig. 122:3476-89
-
(2012)
J. Clin. Investig.
, vol.122
, pp. 3476-3489
-
-
Petrasek, J.1
Bala, S.2
Csak, T.3
Lippai, D.4
Kodys, K.5
-
189
-
-
84896709837
-
NLRP3inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
-
Wree A, EguchiA,McGeoughMD, Pena CA, Johnson CD, et al. 2014.NLRP3inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 59:898-910
-
(2014)
Hepatology
, vol.59
, pp. 898-910
-
-
Wree, A.1
Eguchi, A.2
McGeough, M.D.3
Pena, C.A.4
Johnson, C.D.5
-
191
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, et al. 2009. Autophagy regulates lipid metabolism. Nature 458:1131-35
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
-
193
-
-
80054788704
-
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes
-
Mei S, Ni HM, Manley S, Bockus A, Kassel KM, et al. 2011. Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J. Pharmacol. Exp. Ther. 339:487-98
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.339
, pp. 487-498
-
-
Mei, S.1
Ni, H.M.2
Manley, S.3
Bockus, A.4
Kassel, K.M.5
-
195
-
-
84859942552
-
Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
-
Lomonaco R, Ortiz-Lopez C, Orsak B, Webb A, Hardies J, et al. 2012. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology 55:1389-97
-
(2012)
Hepatology
, vol.55
, pp. 1389-1397
-
-
Lomonaco, R.1
Ortiz-Lopez, C.2
Orsak, B.3
Webb, A.4
Hardies, J.5
-
196
-
-
0036022846
-
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
-
Leclercq IA, Farrell GC, Schriemer R, RobertsonGR. 2002. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J. Hepatol. 37:206-13
-
(2002)
J. Hepatol.
, vol.37
, pp. 206-213
-
-
Leclercq, I.A.1
Farrell, G.C.2
Schriemer, R.3
Robertson, G.R.4
-
197
-
-
33751545966
-
Leptin and liver tissue repair:Do rodent models provide the answers?
-
Marra F. 2007. Leptin and liver tissue repair:Do rodent models provide the answers? J. Hepatol. 46:12-18
-
(2007)
J. Hepatol.
, vol.46
, pp. 12-18
-
-
Marra, F.1
-
198
-
-
56149119778
-
Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism
-
Jiang JX, Mikami K, Shah VH, Torok NJ. 2008. Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism. Hepatology 48:1497-505
-
(2008)
Hepatology
, vol.48
, pp. 1497-1505
-
-
Jiang, J.X.1
Mikami, K.2
Shah, V.H.3
Torok, N.J.4
-
199
-
-
19544378172
-
The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology
-
Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. 2005. The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am. J. Pathol. 166:1655-69
-
(2005)
Am. J. Pathol.
, vol.166
, pp. 1655-1669
-
-
Ding, X.1
Saxena, N.K.2
Lin, S.3
Xu, A.4
Srinivasan, S.5
Anania, F.A.6
-
200
-
-
67650963803
-
Kupffer cells mediate leptin-induced liver fibrosis
-
Wang J, Leclercq I, Brymora JM, Xu N, Ramezani-Moghadam M, et al. 2009. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology 137:713-23
-
(2009)
Gastroenterology
, vol.137
, pp. 713-723
-
-
Wang, J.1
Leclercq, I.2
Brymora, J.M.3
Xu, N.4
Ramezani-Moghadam, M.5
-
201
-
-
10744228583
-
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
-
Kamada Y, Tamura S, Kiso S,Matsumoto H, Saji Y, et al. 2003. Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology 125:1796-807
-
(2003)
Gastroenterology
, vol.125
, pp. 1796-1807
-
-
Kamada, Y.1
Tamura, S.2
Kiso, S.3
Matsumoto, H.4
Saji, Y.5
-
202
-
-
39549118017
-
Adenosinemonophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells
-
Caligiuri A, BertolaniC,Guerra CT,Aleffi S, Galastri S, et al. 2008. Adenosinemonophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. Hepatology 47:668-76
-
(2008)
Hepatology
, vol.47
, pp. 668-676
-
-
Caligiuri, A.1
Bertolani, C.2
Guerra, C.T.3
Aleffi, S.4
Galastri, S.5
-
203
-
-
68049110522
-
The metabolic syndrome: How it may influence hepatic stellate cell activation and hepatic fibrosis
-
Lanthier N, Horsmans Y, Leclercq IA. 2009. The metabolic syndrome: how it may influence hepatic stellate cell activation and hepatic fibrosis. Curr. Opin. Clin. Nutr. Metab. Care 12:404-11
-
(2009)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.12
, pp. 404-411
-
-
Lanthier, N.1
Horsmans, Y.2
Leclercq, I.A.3
-
204
-
-
66149104271
-
Angiotensin II activates i kappaB kinase phosphorylation of RelA at ser 536 to promote myofibroblast survival and liver fibrosis
-
Oakley F, Teoh V, Ching ASG, Bataller R, Colmenero J, et al. 2009. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology 136:2334-44.e1
-
(2009)
Gastroenterology
, vol.136
, pp. 2334e1-2344e1
-
-
Oakley, F.1
Teoh, V.2
Ching, A.S.G.3
Bataller, R.4
Colmenero, J.5
-
205
-
-
0034802171
-
High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
-
Paradis V, PerlemuterG, Bonvoust F,Dargere D, Parfait B, et al. 2001. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology 34:738-44
-
(2001)
Hepatology
, vol.34
, pp. 738-744
-
-
Paradis, V.1
Perlemuter, G.2
Bonvoust, F.3
Dargere, D.4
Parfait, B.5
-
206
-
-
0034680787
-
Peroxisome proliferator-activated receptors and hepatic stellate cell activation
-
Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF Jr., et al. 2000. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J. Biol. Chem. 275:35715-22
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35715-35722
-
-
Miyahara, T.1
Schrum, L.2
Rippe, R.3
Xiong, S.4
Yee, H.F.5
-
207
-
-
0033855572
-
Ligands of peroxisome proliferator-activated receptorγmodulate profibrogenic and proinflammatory actions in hepatic stellate cells
-
Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, et al. 2000. Ligands of peroxisome proliferator-activated receptorγmodulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology 119:466-78
-
(2000)
Gastroenterology
, vol.119
, pp. 466-478
-
-
Marra, F.1
Efsen, E.2
Romanelli, R.G.3
Caligiuri, A.4
Pastacaldi, S.5
-
208
-
-
84885957361
-
Cell-specific PPARγdeficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells
-
Moran-Salvador E, Titos E, Rius B, Gonzalez-Periz A, Garcia-Alonso V, et al. 2013. Cell-specific PPARγdeficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells. J. Hepatol. 59:1045-53
-
(2013)
J. Hepatol.
, vol.59
, pp. 1045-1053
-
-
Moran-Salvador, E.1
Titos, E.2
Rius, B.3
Gonzalez-Periz, A.4
Garcia-Alonso, V.5
-
209
-
-
84888285959
-
Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
-
Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, et al. 2013. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology 58:1941-52
-
(2013)
Hepatology
, vol.58
, pp. 1941-1952
-
-
Staels, B.1
Rubenstrunk, A.2
Noel, B.3
Rigou, G.4
Delataille, P.5
-
210
-
-
56149126257
-
Nuclear bile acid receptor farnesoid X receptor meets nuclear factor-kappaB: New insights into hepatic inflammation
-
Wagner M, Zollner G, TraunerM. 2008. Nuclear bile acid receptor farnesoid X receptor meets nuclear factor-kappaB: new insights into hepatic inflammation. Hepatology 48:1383-86
-
(2008)
Hepatology
, vol.48
, pp. 1383-1386
-
-
Wagner, M.1
Zollner, G.2
Trauner, M.3
-
211
-
-
56149085041
-
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
-
Wang YD, Chen WD,WangM, YuD, Forman BM, HuangW. 2008. Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 48:1632-43
-
(2008)
Hepatology
, vol.48
, pp. 1632-1643
-
-
Wang, Y.D.1
Chen, W.D.2
Wang, M.3
Yu, D.4
Forman, B.M.5
Huang, W.6
-
212
-
-
67649210759
-
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
-
Zhang S, Wang J, Liu Q, Harnish DC. 2009. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J. Hepatol. 51:380-88
-
(2009)
J. Hepatol.
, vol.51
, pp. 380-388
-
-
Zhang, S.1
Wang, J.2
Liu, Q.3
Harnish, D.C.4
-
213
-
-
84880664792
-
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
-
Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, et al. 2013. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 145:574-82.e1
-
(2013)
Gastroenterology
, vol.145
, pp. 574e1-582e1
-
-
Mudaliar, S.1
Henry, R.R.2
Sanyal, A.J.3
Morrow, L.4
Marschall, H.U.5
-
214
-
-
84894875873
-
Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice
-
Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, et al. 2014. Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. Hepatology 59:154-69
-
(2014)
Hepatology
, vol.59
, pp. 154-169
-
-
Tomita, K.1
Teratani, T.2
Suzuki, T.3
Shimizu, M.4
Sato, H.5
-
215
-
-
84879132692
-
Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome
-
Van Rooyen DM, Gan LT, Yeh MM, HaighWG, Larter CZ, et al. 2013. Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome. J. Hepatol. 59:144-52
-
(2013)
J. Hepatol.
, vol.59
, pp. 144-152
-
-
Van Rooyen, D.M.1
Gan, L.T.2
Yeh, M.M.3
Haigh, W.G.4
Larter, C.Z.5
-
216
-
-
33745003240
-
CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
-
Teixeira-Clerc F, Julien B, Grenard P, Tran Van Nhieu J, Deveaux V, et al. 2006. CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis. Nat. Med. 12:671-76
-
(2006)
Nat. Med.
, vol.12
, pp. 671-676
-
-
Teixeira-Clerc, F.1
Julien, B.2
Grenard, P.3
Tran Van Nhieu, J.4
Deveaux, V.5
-
217
-
-
15744388722
-
Antifibrogenic role of the cannabinoid receptor CB2 in the liver
-
Julien B, Grenard P, Teixeira-Clerc F, Van Nhieu JT, Li L, et al. 2005. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology 128:742-55
-
(2005)
Gastroenterology
, vol.128
, pp. 742-755
-
-
Julien, B.1
Grenard, P.2
Teixeira-Clerc, F.3
Van Nhieu, J.T.4
Li, L.5
-
220
-
-
78349299099
-
Fat tissue, aging, and cellular senescence
-
Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, et al. 2010. Fat tissue, aging, and cellular senescence. Aging Cell 9:667-84
-
(2010)
Aging Cell
, vol.9
, pp. 667-684
-
-
Tchkonia, T.1
Morbeck, D.E.2
Von Zglinicki, T.3
Van Deursen, J.4
Lustgarten, J.5
-
221
-
-
84857790798
-
ROS-generating NADPHoxidaseNOX4is a critical mediator in oncogenic H-Ras-inducedDNAdamage and subsequent senescence
-
Weyemi U, Lagente-Chevallier O, Boufraqech M, Prenois F, Courtin F, et al. 2012. ROS-generating NADPHoxidaseNOX4is a critical mediator in oncogenic H-Ras-inducedDNAdamage and subsequent senescence. Oncogene 31:1117-29
-
(2012)
Oncogene
, vol.31
, pp. 1117-1129
-
-
Weyemi, U.1
Lagente-Chevallier, O.2
Boufraqech, M.3
Prenois, F.4
Courtin, F.5
-
222
-
-
60849127227
-
Cellular senescence, ageing and disease
-
Burton DG. 2009. Cellular senescence, ageing and disease. Age 31:1-9
-
(2009)
Age
, vol.31
, pp. 1-9
-
-
Burton, D.G.1
-
223
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, et al. 2008. Senescence of activated stellate cells limits liver fibrosis. Cell 134:657-67
-
(2008)
Cell
, vol.134
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.A.3
Hearn, S.4
Simon, J.5
-
224
-
-
84874115065
-
Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease
-
Aravinthan A, Scarpini C, Tachtatzis P, Verma S, Penrhyn-Lowe S, et al. 2013. Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease. J. Hepatol. 58:549-56
-
(2013)
J. Hepatol.
, vol.58
, pp. 549-556
-
-
Aravinthan, A.1
Scarpini, C.2
Tachtatzis, P.3
Verma, S.4
Penrhyn-Lowe, S.5
-
225
-
-
72749094687
-
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
-
Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, et al. 2009. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am. J. Physiol. Gastrointest. Liver Physiol. 297:G1093-106
-
(2009)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.297
, pp. G1093-G1106
-
-
Choi, S.S.1
Omenetti, A.2
Witek, R.P.3
Moylan, C.A.4
Syn, W.K.5
-
227
-
-
70349436007
-
Hedgehog-mediated epithelialto-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease
-
Syn WK, Jung Y, Omenetti A, Abdelmalek M, Guy CD, et al. 2009. Hedgehog-mediated epithelialto-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology 137:1478-88.e8
-
(2009)
Gastroenterology
, vol.137
, pp. 1478e8-1488e8
-
-
Syn, W.K.1
Jung, Y.2
Omenetti, A.3
Abdelmalek, M.4
Guy, C.D.5
-
228
-
-
84859444880
-
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
-
Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, et al. 2012. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 142:938-46
-
(2012)
Gastroenterology
, vol.142
, pp. 938-946
-
-
Hernandez-Gea, V.1
Ghiassi-Nejad, Z.2
Rozenfeld, R.3
Gordon, R.4
Fiel, M.I.5
-
229
-
-
84861872575
-
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
-
Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. 2012. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am. J. Physiol. Gastrointest. Liver Physiol. 302:G1310-21
-
(2012)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.302
, pp. G1310-G1321
-
-
Miura, K.1
Yang, L.2
Van Rooijen, N.3
Ohnishi, H.4
Seki, E.5
-
230
-
-
84857055199
-
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
-
Baeck C, Wehr A, Karlmark KR, Heymann F, Vucur M, et al. 2012. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61:416-26
-
(2012)
Gut
, vol.61
, pp. 416-426
-
-
Baeck, C.1
Wehr, A.2
Karlmark, K.R.3
Heymann, F.4
Vucur, M.5
-
231
-
-
84896707511
-
Pharmacological inhibition of the chemokineC-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice
-
Baeck C, Wei X, Bartneck M, Fech V, Heymann F, et al. 2014. Pharmacological inhibition of the chemokineC-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice. Hepatology 59:1060-72
-
(2014)
Hepatology
, vol.59
, pp. 1060-1072
-
-
Baeck, C.1
Wei, X.2
Bartneck, M.3
Fech, V.4
Heymann, F.5
-
232
-
-
13144306071
-
Genome-wide association studies for common diseases and complex traits
-
Hirschhorn JN, Daly MJ. 2005. Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6:95-108
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 95-108
-
-
Hirschhorn, J.N.1
Daly, M.J.2
-
233
-
-
65249188812
-
Heritability of nonalcoholic fatty liver disease
-
Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, et al. 2009. Heritability of nonalcoholic fatty liver disease. Gastroenterology 136:1585-92
-
(2009)
Gastroenterology
, vol.136
, pp. 1585-1592
-
-
Schwimmer, J.B.1
Celedon, M.A.2
Lavine, J.E.3
Salem, R.4
Campbell, N.5
-
234
-
-
64549098124
-
Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: A study in monozygotic and dizygotic twins
-
Makkonen J, Pietilainen KH, Rissanen A, Kaprio J, Yki-Jarvinen H. 2009. Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: A study in monozygotic and dizygotic twins. J. Hepatol. 50:1035-42
-
(2009)
J. Hepatol.
, vol.50
, pp. 1035-1042
-
-
Makkonen, J.1
Pietilainen, K.H.2
Rissanen, A.3
Kaprio, J.4
Yki-Jarvinen, H.5
-
235
-
-
84857429228
-
Ethnicity and nonalcoholic fatty liver disease
-
Bambha K, Belt P, Abraham M,Wilson LA, Pabst M, et al. 2012. Ethnicity and nonalcoholic fatty liver disease. Hepatology 55:769-80
-
(2012)
Hepatology
, vol.55
, pp. 769-780
-
-
Bambha, K.1
Belt, P.2
Abraham, M.3
Wilson, L.A.4
Pabst, M.5
-
237
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, et al. 2008. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40:1461-65
-
(2008)
Nat. Genet.
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
Pertsemlidis, A.4
Cox, D.5
-
238
-
-
53049090077
-
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
-
Yuan X, WaterworthD,Perry JR,Lim N, Song K, et al. 2008. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am. J. Hum. Genet. 83:520-28
-
(2008)
Am. J. Hum. Genet.
, vol.83
, pp. 520-528
-
-
Yuan, X.1
Waterworth, D.2
Perry, J.R.3
Lim, N.4
Song, K.5
-
239
-
-
79953745343
-
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
-
Speliotes EK, Yerges-Armstrong LM,Wu J, Hernaez R, Kim LJ, et al. 2011. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLOS Genet. 7:e1001324
-
(2011)
PLOS Genet.
, vol.7
, pp. e1001324
-
-
Speliotes, E.K.1
Yerges-Armstrong, L.M.2
Wu, J.3
Hernaez, R.4
Kim, L.J.5
-
240
-
-
80055024880
-
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
-
Chambers JC, Zhang W, Sehmi J, Li X,WassMN, et al. 2011. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat. Genet. 43:1131-38
-
(2011)
Nat. Genet.
, vol.43
, pp. 1131-1138
-
-
Chambers, J.C.1
Zhang, W.2
Sehmi, J.3
Li, X.4
Wass, M.N.5
-
241
-
-
84876785272
-
The ERLIN1-CHUKCWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study
-
Feitosa MF, Wojczynski MK, North KE, Zhang Q, Province MA, et al. 2013. The ERLIN1-CHUKCWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study. Atherosclerosis 228:175-80
-
(2013)
Atherosclerosis
, vol.228
, pp. 175-180
-
-
Feitosa, M.F.1
Wojczynski, M.K.2
North, K.E.3
Zhang, Q.4
Province, M.A.5
-
242
-
-
77950607738
-
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patientswith nonalcoholic fatty liver disease
-
Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, et al. 2010. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patientswith nonalcoholic fatty liver disease. Hepatology 51:1209-17
-
(2010)
Hepatology
, vol.51
, pp. 1209-1217
-
-
Valenti, L.1
Al-Serri, A.2
Daly, A.K.3
Galmozzi, E.4
Rametta, R.5
-
243
-
-
77956636268
-
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
-
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, Nash CRN. 2010. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 52:894-903
-
(2010)
Hepatology
, vol.52
, pp. 894-903
-
-
Rotman, Y.1
Koh, C.2
Zmuda, J.M.3
Kleiner, D.E.4
Liang, T.J.5
Nash, C.R.N.6
-
244
-
-
77349106712
-
A common variant in the adiponutrin gene influences liver enzyme values
-
Kollerits B, Coassin S, Kiechl S,Hunt SC, Paulweber B, et al. 2010. A common variant in the adiponutrin gene influences liver enzyme values. J. Med. Genet. 47:116-19
-
(2010)
J. Med. Genet.
, vol.47
, pp. 116-119
-
-
Kollerits, B.1
Coassin, S.2
Kiechl, S.3
Hunt, S.C.4
Paulweber, B.5
-
245
-
-
84902688337
-
Carriage of the PNPLA3 rs738409 C > G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
-
Liu YL, Patman GL, Leathart JB, Piguet AC, Burt AD, et al. 2014. Carriage of the PNPLA3 rs738409 C > G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma. J. Hepatol. 61:75-81
-
(2014)
J. Hepatol.
, vol.61
, pp. 75-81
-
-
Liu, Y.L.1
Patman, G.L.2
Leathart, J.B.3
Piguet, A.C.4
Burt, A.D.5
-
246
-
-
8844226709
-
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
-
Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, et al. 2004. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306:1383-86
-
(2004)
Science
, vol.306
, pp. 1383-1386
-
-
Zimmermann, R.1
Strauss, J.G.2
Haemmerle, G.3
Schoiswohl, G.4
Birner-Gruenberger, R.5
-
247
-
-
0037984885
-
The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad
-
Rydel TJ, Williams JM, Krieger E, Moshiri F, Stallings WC, et al. 2003. The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad. Biochemistry 42:6696-708
-
(2003)
Biochemistry
, vol.42
, pp. 6696-6708
-
-
Rydel, T.J.1
Williams, J.M.2
Krieger, E.3
Moshiri, F.4
Stallings, W.C.5
-
248
-
-
77949895032
-
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
-
He S, McPhaul C, Li JZ, Garuti R, Kinch L, et al. 2010. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J. Biol. Chem. 285:6706-15
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 6706-6715
-
-
He, S.1
McPhaul, C.2
Li, J.Z.3
Garuti, R.4
Kinch, L.5
-
249
-
-
74249093842
-
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
-
Romeo S, Sentinelli F, Dash S, Yeo GS, Savage DB, et al. 2010. Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. Int. J. Obes. 34:190-94
-
(2010)
Int. J. Obes.
, vol.34
, pp. 190-194
-
-
Romeo, S.1
Sentinelli, F.2
Dash, S.3
Yeo, G.S.4
Savage, D.B.5
-
250
-
-
84869224701
-
Patatin-like phospholipase domaincontaining 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
-
Pirazzi C, Adiels M, BurzaMA, Mancina RM, LevinM, et al. 2012. Patatin-like phospholipase domaincontaining 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro. J. Hepatol. 57:1276-82
-
(2012)
J. Hepatol.
, vol.57
, pp. 1276-1282
-
-
Pirazzi, C.1
Adiels, M.2
Burza, M.A.3
Mancina, R.M.4
Levin, M.5
-
251
-
-
27444433258
-
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members
-
Lake AC, Sun Y, Li JL, Kim JE, Johnson JW, et al. 2005. Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. J. Lipid Res. 46:2477-87
-
(2005)
J. Lipid Res.
, vol.46
, pp. 2477-2487
-
-
Lake, A.C.1
Sun, Y.2
Li, J.L.3
Kim, J.E.4
Johnson, J.W.5
-
252
-
-
33748745960
-
Characterization of the human patatin-like phospholipase family
-
Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ. 2006. Characterization of the human patatin-like phospholipase family. J. Lipid Res. 47:1940-49
-
(2006)
J. Lipid Res.
, vol.47
, pp. 1940-1949
-
-
Wilson, P.A.1
Gardner, S.D.2
Lambie, N.M.3
Commans, S.A.4
Crowther, D.J.5
-
253
-
-
67349174005
-
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
-
Kotronen A, Johansson LE, Johansson LM, Roos C, Westerbacka J, et al. 2009. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 52:1056-60
-
(2009)
Diabetologia
, vol.52
, pp. 1056-1060
-
-
Kotronen, A.1
Johansson, L.E.2
Johansson, L.M.3
Roos, C.4
Westerbacka, J.5
-
254
-
-
77952409634
-
A feed-forward loop amplifies nutritional regulation of PNPLA3
-
Huang Y, He S, Li JZ, Seo YK, Osborne TF, et al. 2010. A feed-forward loop amplifies nutritional regulation of PNPLA3. PNAS 107:7892-97
-
(2010)
PNAS
, vol.107
, pp. 7892-7897
-
-
Huang, Y.1
He, S.2
Li, J.Z.3
Seo, Y.K.4
Osborne, T.F.5
-
255
-
-
77956625538
-
Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
-
Chen W, Chang B, Li L, Chan L. 2010. Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. Hepatology 52:1134-42
-
(2010)
Hepatology
, vol.52
, pp. 1134-1142
-
-
Chen, W.1
Chang, B.2
Li, L.3
Chan, L.4
-
256
-
-
84868609657
-
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
-
Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, et al. 2012. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J. Clin. Investig. 122:4130-44
-
(2012)
J. Clin. Investig.
, vol.122
, pp. 4130-4144
-
-
Li, J.Z.1
Huang, Y.2
Karaman, R.3
Ivanova, P.T.4
Brown, H.A.5
-
257
-
-
78751489992
-
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
-
BasantaniMK, Sitnick MT, Cai L, BrennerDS, GardnerNP, et al. 2011. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J. Lipid Res. 52(2):318-29
-
(2011)
J. Lipid Res.
, vol.52
, Issue.2
, pp. 318-329
-
-
Basantani, M.K.1
Sitnick, M.T.2
Cai, L.3
Brenner, D.S.4
Gardner, N.P.5
-
258
-
-
84860528183
-
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis
-
Perttilä J, Huaman-Samanez C, Caron S, Tanhuanpää K, Staels B, et al. 2012. PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis. Am. J. Physiol. Endocrinol. Metab. 302(9):E1063-69
-
(2012)
Am. J. Physiol. Endocrinol. Metab.
, vol.302
, Issue.9
, pp. E1063-E1069
-
-
Perttilä, J.1
Huaman-Samanez, C.2
Caron, S.3
Tanhuanpää, K.4
Staels, B.5
-
259
-
-
84860465005
-
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase
-
Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, et al. 2012. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab. 15(5):691-702
-
(2012)
Cell Metab.
, vol.15
, Issue.5
, pp. 691-702
-
-
Kumari, M.1
Schoiswohl, G.2
Chitraju, C.3
Paar, M.4
Cornaciu, I.5
-
260
-
-
84903996547
-
PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
-
Pirazzi C, Valenti L, Motta BM, Pingitore P, Hedfalk K, et al. 2014. PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells. Hum. Mol. Genet. 23:4077-85
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 4077-4085
-
-
Pirazzi, C.1
Valenti, L.2
Motta, B.M.3
Pingitore, P.4
Hedfalk, K.5
-
261
-
-
84896695345
-
Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mousemodels of steatohepatitis and endotoxemia
-
Jha P, ClaudelT, Baghdasaryan A,MuellerM,Halilbasic E, et al. 2014. Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mousemodels of steatohepatitis and endotoxemia. Hepatology 59:858-69
-
(2014)
Hepatology
, vol.59
, pp. 858-869
-
-
Jha, P.1
Claudel, T.2
Baghdasaryan, A.3
Mueller, M.4
Halilbasic, E.5
-
262
-
-
70349980881
-
The P446L variant inGCKRassociated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
-
Beer NL,TribbleND, McCulloch LJ, Roos C, Johnson PR, et al. 2009. The P446L variant inGCKRassociated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum. Mol. Genet. 18:4081-88
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4081-4088
-
-
Beer, N.L.1
Tribble, N.D.2
McCulloch, L.J.3
Roos, C.4
Johnson, P.R.5
-
263
-
-
84857429794
-
Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphisms
-
Valenti L, Alisi A, Nobili V. 2012. Unraveling the genetics of fatty liver in obese children: additive effect of P446L GCKR and I148M PNPLA3 polymorphisms. Hepatology 55:661-63
-
(2012)
Hepatology
, vol.55
, pp. 661-663
-
-
Valenti, L.1
Alisi, A.2
Nobili, V.3
-
264
-
-
84883241741
-
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent
-
Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, et al. 2013. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology 58:966-75
-
(2013)
Hepatology
, vol.58
, pp. 966-975
-
-
Palmer, N.D.1
Musani, S.K.2
Yerges-Armstrong, L.M.3
Feitosa, M.F.4
Bielak, L.F.5
-
265
-
-
84898058711
-
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
-
Kozlitina J, Smagris E, Stender S, Nordestgaard BG, Zhou HH, et al. 2014. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 46:352-56
-
(2014)
Nat. Genet.
, vol.46
, pp. 352-356
-
-
Kozlitina, J.1
Smagris, E.2
Stender, S.3
Nordestgaard, B.G.4
Zhou, H.H.5
-
266
-
-
84898058547
-
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
-
Holmen OL, Zhang H, Fan Y, Hovelson DH, Schmidt EM, et al. 2014. Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nat. Genet. 46:345-51
-
(2014)
Nat. Genet.
, vol.46
, pp. 345-351
-
-
Holmen, O.L.1
Zhang, H.2
Fan, Y.3
Hovelson, D.H.4
Schmidt, E.M.5
-
267
-
-
84903708160
-
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
-
Liu YL, Reeves HL, Burt AD, Tiniakos D, McPherson S, et al. 2014. TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease. Nat. Commun. 5:4309
-
(2014)
Nat. Commun.
, vol.5
, pp. 4309
-
-
Liu, Y.L.1
Reeves, H.L.2
Burt, A.D.3
Tiniakos, D.4
McPherson, S.5
-
268
-
-
84921487729
-
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
-
Dongiovanni P, Petta S, Maglio C, Fracanzani AL, Pipitone R, et al. 2015. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology 61:506-14
-
(2015)
Hepatology
, vol.61
, pp. 506-514
-
-
Dongiovanni, P.1
Petta, S.2
Maglio, C.3
Fracanzani, A.L.4
Pipitone, R.5
-
269
-
-
84921528716
-
Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity
-
Sookoian S, Castano GO, Scian R, Mallardi P, Fernandez Gianotti T, et al. 2015. Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity. Hepatology 61:515-25
-
(2015)
Hepatology
, vol.61
, pp. 515-525
-
-
Sookoian, S.1
Castano, G.O.2
Scian, R.3
Mallardi, P.4
Fernandez Gianotti, T.5
-
270
-
-
75449091784
-
Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
-
Wong VW, Vergniol J,Wong GL, Foucher J, Chan HL, et al. 2010. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 51:454-62
-
(2010)
Hepatology
, vol.51
, pp. 454-462
-
-
Wong, V.W.1
Vergniol, J.2
Wong, G.L.3
Foucher, J.4
Chan, H.L.5
-
271
-
-
83755163159
-
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
-
Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, et al. 2012. A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. Gastroenterology 142:152-64.e10
-
(2012)
Gastroenterology
, vol.142
, pp. 152e10-164e10
-
-
Teratani, T.1
Tomita, K.2
Suzuki, T.3
Oshikawa, T.4
Yokoyama, H.5
-
272
-
-
84904795250
-
Epigenetics in liver disease
-
Mann DA. 2014. Epigenetics in liver disease. Hepatology 60:1418-25
-
(2014)
Hepatology
, vol.60
, pp. 1418-1425
-
-
Mann, D.A.1
-
273
-
-
75149141045
-
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
-
714.e1-4
-
Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, et al. 2010. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology 138:705-14, 714.e1-4
-
(2010)
Gastroenterology
, vol.138
, pp. 705-714
-
-
Mann, J.1
Chu, D.C.2
Maxwell, A.3
Oakley, F.4
Zhu, N.L.5
-
274
-
-
84868646303
-
Multigenerational epigenetic adaptation of the hepatic wound-healing response
-
Zeybel M, HardyT,WongYK, Mathers JC, FoxCR, et al. 2012. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat. Med. 18:1369-77
-
(2012)
Nat. Med.
, vol.18
, pp. 1369-1377
-
-
Zeybel, M.1
Hardy, T.2
Wong, Y.K.3
Mathers, J.C.4
Fox, C.R.5
-
275
-
-
84886772574
-
Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease
-
Murphy SK, Yang H, Moylan CA, Pang H, Dellinger A, et al. 2013. Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. Gastroenterology 145:1076-87
-
(2013)
Gastroenterology
, vol.145
, pp. 1076-1087
-
-
Murphy, S.K.1
Yang, H.2
Moylan, C.A.3
Pang, H.4
Dellinger, A.5
-
276
-
-
84969179560
-
Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease
-
Zeybel M, Hardy T, Robinson SM, Fox C, Anstee QM, et al. 2015. Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. Clin. Epigenet. 7:25
-
(2015)
Clin. Epigenet.
, vol.7
, pp. 25
-
-
Zeybel, M.1
Hardy, T.2
Robinson, S.M.3
Fox, C.4
Anstee, Q.M.5
-
277
-
-
33645075443
-
MIR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
-
Esau C, Davis S, Murray SF, Yu XX, Pandey SK, et al. 2006. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 3:87-98
-
(2006)
Cell Metab.
, vol.3
, pp. 87-98
-
-
Esau, C.1
Davis, S.2
Murray, S.F.3
Yu, X.X.4
Pandey, S.K.5
-
278
-
-
0345448923
-
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
-
Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, et al. 2003. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 38:1529-39
-
(2003)
Hepatology
, vol.38
, pp. 1529-1539
-
-
Sekiya, M.1
Yahagi, N.2
Matsuzaka, T.3
Najima, Y.4
Nakakuki, M.5
-
279
-
-
26444434340
-
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
-
Dentin R, Benhamed F,Pegorier JP, Foufelle F, ViolletB, et al. 2005. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J. Clin. Investig. 115:2843-54
-
(2005)
J. Clin. Investig.
, vol.115
, pp. 2843-2854
-
-
Dentin, R.1
Benhamed, F.2
Pegorier, J.P.3
Foufelle, F.4
Viollet, B.5
-
280
-
-
84858703583
-
Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
-
Parker HM, Johnson NA, Burdon CA, Cohn JS, O'Connor HT, George J. 2012. Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis. J. Hepatol. 56:944-51
-
(2012)
J. Hepatol.
, vol.56
, pp. 944-951
-
-
Parker, H.M.1
Johnson, N.A.2
Burdon, C.A.3
Cohn, J.S.4
O'Connor, H.T.5
George, J.6
-
281
-
-
2942706241
-
Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
-
Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, et al. 2004. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin. Sci. 106:635-43
-
(2004)
Clin. Sci.
, vol.106
, pp. 635-643
-
-
Araya, J.1
Rodrigo, R.2
Videla, L.A.3
Thielemann, L.4
Orellana, M.5
-
282
-
-
70349738087
-
Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome
-
Abid A, Taha O, Nseir W, Farah R, Grosovski M, Assy N. 2009. Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome. J. Hepatol. 51:918-24
-
(2009)
J. Hepatol.
, vol.51
, pp. 918-924
-
-
Abid, A.1
Taha, O.2
Nseir, W.3
Farah, R.4
Grosovski, M.5
Assy, N.6
-
283
-
-
77952692915
-
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
-
AbdelmalekMF, Suzuki A, GuyC,Unalp-Arida A, Colvin R, et al. 2010. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51:1961-71
-
(2010)
Hepatology
, vol.51
, pp. 1961-1971
-
-
Abdelmalek, M.F.1
Suzuki, A.2
Guy, C.3
Unalp-Arida, A.4
Colvin, R.5
-
284
-
-
43049161319
-
Antibiotics protect against fructoseinduced hepatic lipid accumulation in mice: Role of endotoxin
-
Bergheim I, Weber S, Vos M, Kramer S, Volynets V, et al. 2008. Antibiotics protect against fructoseinduced hepatic lipid accumulation in mice: role of endotoxin. J. Hepatol. 48:983-92
-
(2008)
J. Hepatol.
, vol.48
, pp. 983-992
-
-
Bergheim, I.1
Weber, S.2
Vos, M.3
Kramer, S.4
Volynets, V.5
-
285
-
-
77955488532
-
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis
-
Lee JH, Wada T, Febbraio M, He JH, Matsubara T, et al. 2010. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 139:653-63
-
(2010)
Gastroenterology
, vol.139
, pp. 653-663
-
-
Lee, J.H.1
Wada, T.2
Febbraio, M.3
He, J.H.4
Matsubara, T.5
-
286
-
-
0017336131
-
Patterns of hepatic morphology in jejunoileal bypass patients
-
Peters RL. 1977. Patterns of hepatic morphology in jejunoileal bypass patients.Am. J. Clin.Nutr. 30:53-57
-
(1977)
Am. J. Clin.Nutr.
, vol.30
, pp. 53-57
-
-
Peters, R.L.1
-
287
-
-
0020065283
-
Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition
-
Drenick EJ, Fisler J, Johnson D. 1982. Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition. Gastroenterology 82:535-48
-
(1982)
Gastroenterology
, vol.82
, pp. 535-548
-
-
Drenick, E.J.1
Fisler, J.2
Johnson, D.3
-
288
-
-
0035125052
-
The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor αin the pathogenesis of non-alcoholic steatohepatitis
-
Wigg AJ, Roberts-Thomson IC, Dymock RB,McCarthy PJ, Grose RH, Cummins AG. 2001. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor αin the pathogenesis of non-alcoholic steatohepatitis. Gut 48:206-11
-
(2001)
Gut
, vol.48
, pp. 206-211
-
-
Wigg, A.J.1
Roberts-Thomson, I.C.2
Dymock, R.B.3
McCarthy, P.J.4
Grose, R.H.5
Cummins, A.G.6
-
289
-
-
0033868131
-
Small-bowel bacterial overgrowth in diabetic subjects is associated with cardiovascular autonomic neuropathy
-
Zietz B, Lock G, Straub RH, Braun B, Scholmerich J, Palitzsch KD. 2000. Small-bowel bacterial overgrowth in diabetic subjects is associated with cardiovascular autonomic neuropathy. Diabetes Care 23:1200-1
-
(2000)
Diabetes Care
, vol.23
, pp. 1200-1201
-
-
Zietz, B.1
Lock, G.2
Straub, R.H.3
Braun, B.4
Scholmerich, J.5
Palitzsch, K.D.6
-
290
-
-
38449120093
-
Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: Evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis
-
Ruiz AG, Casafont F, Crespo J, Cayon A, Mayorga M, et al. 2007. Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis. Obes. Surg. 17:1374-80
-
(2007)
Obes. Surg.
, vol.17
, pp. 1374-1380
-
-
Ruiz, A.G.1
Casafont, F.2
Crespo, J.3
Cayon, A.4
Mayorga, M.5
-
291
-
-
68949148889
-
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
-
Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, et al. 2009. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49:1877-87
-
(2009)
Hepatology
, vol.49
, pp. 1877-1887
-
-
Miele, L.1
Valenza, V.2
La Torre, G.3
Montalto, M.4
Cammarota, G.5
-
292
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, et al. 2011. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745-57
-
(2011)
Cell
, vol.145
, pp. 745-757
-
-
Elinav, E.1
Strowig, T.2
Kau, A.L.3
Henao-Mejia, J.4
Thaiss, C.A.5
-
293
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, et al. 2012. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482:179-85
-
(2012)
Nature
, vol.482
, pp. 179-185
-
-
Henao-Mejia, J.1
Elinav, E.2
Jin, C.3
Hao, L.4
Mehal, W.Z.5
-
294
-
-
33845874101
-
An obesity-associated gut microbiome with increased capacity for energy harvest
-
Turnbaugh PJ, Ley RE, Mahowald MA,Magrini V, Mardis ER, Gordon JI. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027-31
-
(2006)
Nature
, vol.444
, pp. 1027-1031
-
-
Turnbaugh, P.J.1
Ley, R.E.2
Mahowald, M.A.3
Magrini, V.4
Mardis, E.R.5
Gordon, J.I.6
-
295
-
-
8144226856
-
The gut microbiota as an environmental factor that regulates fat storage
-
Backhed F,DingH,Wang T,Hooper LV, Koh GY, et al. 2004. The gut microbiota as an environmental factor that regulates fat storage. PNAS 101:15718-23
-
(2004)
PNAS
, vol.101
, pp. 15718-15723
-
-
Backhed, F.1
Ding, H.2
Wang, T.3
Hooper, L.V.4
Koh, G.Y.5
-
296
-
-
33846542071
-
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
-
Backhed F, Manchester JK, Semenkovich CF, Gordon JI. 2007. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. PNAS 104:979-84
-
(2007)
PNAS
, vol.104
, pp. 979-984
-
-
Backhed, F.1
Manchester, J.K.2
Semenkovich, C.F.3
Gordon, J.I.4
-
297
-
-
0029033928
-
Short-chain acid topical treatment in distal ulcerative-colitis
-
Vernia P, Marcheggiano A, Caprilli R, Frieri G, CorraoG, et al. 1995. Short-chain acid topical treatment in distal ulcerative-colitis. Aliment. Pharmacol. Ther. 9:309-13
-
(1995)
Aliment. Pharmacol. Ther.
, vol.9
, pp. 309-313
-
-
Vernia, P.1
Marcheggiano, A.2
Caprilli, R.3
Frieri, G.4
Corrao, G.5
-
298
-
-
70350666634
-
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
-
Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, et al. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282-886
-
(2009)
Nature
, vol.461
, pp. 1282-1886
-
-
Maslowski, K.M.1
Vieira, A.T.2
Ng, A.3
Kranich, J.4
Sierro, F.5
-
299
-
-
55949091259
-
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid bindingGprotein-coupled receptor,Gpr41
-
Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, et al. 2008. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid bindingGprotein-coupled receptor,Gpr41. PNAS 105:16767-72
-
(2008)
PNAS
, vol.105
, pp. 16767-16772
-
-
Samuel, B.S.1
Shaito, A.2
Motoike, T.3
Rey, F.E.4
Backhed, F.5
-
300
-
-
37049202379
-
The prevention by choline of liver cirrhosis in rats on high fat, low protein diets
-
Blumberg H, McCollum EV. 1941. The prevention by choline of liver cirrhosis in rats on high fat, low protein diets. Science 93:598-99
-
(1941)
Science
, vol.93
, pp. 598-599
-
-
Blumberg, H.1
McCollum, E.V.2
-
301
-
-
33747618036
-
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
-
Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, et al. 2006. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. PNAS 103:12511-16
-
(2006)
PNAS
, vol.103
, pp. 12511-12516
-
-
Dumas, M.E.1
Barton, R.H.2
Toye, A.3
Cloarec, O.4
Blancher, C.5
-
302
-
-
84879604697
-
Intestinal microbiota in patients with nonalcoholic fatty liver disease
-
MouzakiM, Comelli EM, Arendt BM, Bonengel J, Fung SK, et al. 2013. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology 58:120-27
-
(2013)
Hepatology
, vol.58
, pp. 120-127
-
-
Mouzaki, M.1
Comelli, E.M.2
Arendt, B.M.3
Bonengel, J.4
Fung, S.K.5
-
303
-
-
84873296091
-
Characterization of the gutmicrobiomes in non-alcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH
-
Zhu LX, Baker SS, Gill C, LiuWS, Alkhouri RH, et al. 2013. Characterization of the gutmicrobiomes in non-alcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH. Hepatology 57:601-9
-
(2013)
Hepatology
, vol.57
, pp. 601-609
-
-
Zhu, L.X.1
Baker, S.S.2
Gill, C.3
Liu, W.S.4
Alkhouri, R.H.5
-
304
-
-
84899474318
-
Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice
-
De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, et al. 2014. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice. Hepatology 59:1738-49
-
(2014)
Hepatology
, vol.59
, pp. 1738-1749
-
-
De Minicis, S.1
Rychlicki, C.2
Agostinelli, L.3
Saccomanno, S.4
Trozzi, L.5
-
305
-
-
84859812538
-
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
-
Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, et al. 2012. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21:504-16
-
(2012)
Cancer Cell
, vol.21
, pp. 504-516
-
-
Dapito, D.H.1
Mencin, A.2
Gwak, G.Y.3
Pradere, J.P.4
Jang, M.K.5
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