PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 9, 2012, Pages

  Perttilä, Julia ^a   Huaman Samanez, Carolina ^b   Caron, Sandrine ^b   Tanhuanpää, Kimmo ^d   Staels, Bart ^b   Yki Järvinen, Hannele ^a,c   Olkkonen, Vesa M ^a  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b UNIV LILLE   (France)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Isoleucine to methionine change at position 148; Patatin like phospholipase domain containing 3

Indexed keywords

ACETIC ACID; ADENOVIRUS VECTOR; ALBUMIN; BINDING PROTEIN; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; FATTY ACID; GLUCOSE; INSULIN; MESSENGER RNA; MUTANT PROTEIN; OLEIC ACID; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3; PROTEIN; TRIACYLGLYCEROL; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION (PARAMETERS); GENE INDUCTION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HYDROLYSIS; LIPID METABOLISM; LIPOGENESIS; LIVER CELL; LIVER FATTY DEGENERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; TRANSCRIPTION REGULATION;

AMINO ACID SUBSTITUTION; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; GLUCOSE; HEPATOCYTES; HUMANS; LIPASE; LIPOGENESIS; MEMBRANE PROTEINS; MUTATION; STATISTICS, NONPARAMETRIC; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

EID: 84860528183     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00125.2011     Document Type: Article

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