Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 287, Issue 5 50-5, 2004, Pages

  Gao, Daqing ^a   Wei, Chiming ^a   Chen, Lei ^a   Huang, Jiawen ^a   Yang, Shiqi ^a   Diehl, Anna Mae ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

Mismatch repair enzymes; Mitochondria; Reactive oxygen species; Steatohepatitis

Indexed keywords

8 HYDROXYGUANINE; DNA; DNA MISMATCH REPAIR ENZYME MUTY; HYDROGEN PEROXIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MODEL; DNA DAMAGE; DNA REPAIR; EVALUATION; FATTY LIVER; HYPOTHESIS; LIVER CELL; MALE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL DEATH; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR ENZYMES; FATTY LIVER; GUANOSINE; HYDROGEN PEROXIDE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MITOCHONDRIA, LIVER; OXIDATIVE STRESS;

EID: 7044264899     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00228.2004     Document Type: Article

References (44)

1. Avila MA, Berasain C, Torres L, Martin-Duce A, Corrales FJ, Yang H, Prieto J, Lu SC, Caballeria J, Rodes J, and Mato JM. Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol 33: 907-914, 2000.
2. Bailey SM. A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction. Free Radic Res 37: 585-596, 2003.
3. Bohr VA, Stevnsner T, and de Souza-Pinto NC. Mitochondrial DNA repair of oxidative damage in mammalian cells. Gene 286: 127-134, 2002.
4. Boldogh I, Milligan D, Lee MD, Bassett H, Lloyd RS, and McCullough AK. hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs. Nucleic Acids Res 29: 2802-2809, 2001.
5. Cahill A, Cunningham CC, Adachi M, Ishii H, Bailey SM, Fromenty G, and Davies A. Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondria. Alcohol Clin Exp Res 26: 907-915, 2002.
6. Chitturi S and Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 21: 27-41, 2001.
7. Day CP and James O. Steatohepatitis: a tale of two "hits"? Gastroenterology 114: 842-845, 1998.
8. Druzhyna NM, Hollensworth SB, Kelley MR, Wilson GL, and Ledoux SP. Targeting human 8-oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione-induced oxidative stress. Glia 42: 370-378, 2003.
9. Englander EW, Hu Z, Sharma A, Lee HM, Wu ZH, and Greeley GH. Ray MYH, a glycoslase for repair of oxidatively damaged DNA has brain-specific isoforms that localize to neuronal miochondria. J Neurochem 83: 1471-1489, 2002.
10. Enholm S, Hienonen T, Suomalainen A, Lipton L, Tomlinson I, Karja V, Eskelinen M, Mecklin JP, Karhu A, Jarvinen HJ, and Aaltonen LA. Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. Am J Pathol 163: 827-832, 2003.
11. Falck-Ytter Y, Younassi ZM, Marchesini G, and McCullough AJ. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 21: 71-26, 2001.
12. Fortini P, Pascucci B, Parlanti E, D'Errico M, Simonelli V, and Dogliotti E. 8-oxoguanine DNA damage: at the crossroads of alternative repair pathways. Mutat Res 531: 127-139, 2003.
13. Green RM. Hepatic metabolism and not simply the metabolic syndrome. Hepatology 38: 14-17, 2003.
14. Hegler J, Bittner D, Boiteux S, and Epe B. Quantification of oxidative DNA modifications in mitochondria. Carcinogenesis 14: 2309-2312, 1993.
15. Hudson EK, Hogue BA, Souza-Pinto NC, Croteau DK, Anson RM, Bohr VA, and Hansford RG. Age-associated change in mitochondrial DNA damage. Free Radic Res 29: 573-579, 1998.
16. Jougaski M, Rodeheffer RJ, Redfield MM, Yamamoto K, Wei C, McKinley LJ, and Burnett JCJ. Cardiac secretion of adrenomedullin in human heart failure. J Clin Invest 97: 2370-2376, 1996.
17. Kaneshiro Y, Nakano H, Kumada K, Boudjema K, Kitamura N, Shimura H, Barama A, Kigawa G, Tatsuno M, Fujiwara Y, Baek Y, Sasaki J, Nagasaki H, and Yamaguchi M. Augmentation of mitochondrial reduced glutathione by S-adenosyl-L-methionine administration in ischemia-reperfusion injury of the rat steatotic liver induced by choline-methionine-deficient diet. Eur Surg Res 30: 34-42, 1998.
18. Kang D and Hamasaki N. Maintenance of mitochondrial DNA integrity: repair and degradation. Curr Genet 41: 311-322, 2002.
19. Lin H, Roseborough G, Dong Y, Williams GM, and Wei C. DNA damage and repair system in spinal cord ischemia. J Vasc Surg 37: 847-858, 2003.
20. Lopez-Torres M, Gredilla R, Sanz A, and Barja G. Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. Free Radic Biol Med 32: 882-889, 2002.
21. Mansouri A, Gaou I, Fromenty B, Berson A, Letteron P, Degott C, Erlinger S, and Pessayre D. Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease. Gastroenterology 113: 599-605, 1997.
22. Martinez-Chantar ML, Corrales FJ, Martinez-Cruz LA, Garcia-Trevijano ER, Huang ZZ, Chen L, Kanel G, Avila MA, Mato JM, and Lu SC. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J 16: 1292-1294, 2002.
23. Navasumrit P, Margison GP, and O'Connor PJ. Ethanol modulates rat hepatic DNA repair functions. Alcohol Alcohol 36: 369-376, 2001.
24. Ohata K, Hamasaki K, Toriyama K, Matsumoto K, Saeki A, Yanagi K, Abiru S, Nakagawa Y, Shigeno M, Miyazoe S, Ichikawa T, Ishikawa H, Nakao K, and Eguchi K. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer 97: 3036-3043, 2003.
25. Parker AR and Eshleman JR. Human MutY: gene structure, protein functions and interactions, and role in carcinogenesis. Cell Mol Life Sci 60: 2064-2083, 2003.
26. Parker AR, O'Meally RN, Sahin F, Su GH, Racke FK, Nelson WG, DeWeese TL, and Eshleman JR. Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles. J Biol Chem 278: 47937-47945, 2003.
27. Perez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, Castellano G, Colina F, Arenas J, and Solis-Herruzo JA. Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38: 999-1007, 2003.
28. Richter C, Park JW, and Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85: 6465-6467, 1988.
29. Rickwood D, Wilson MT, and Darley-Usmar VM. Mitochondria: A Practical Approach, edited by Darley-Usmar VM, Rickwood D, and Wilson MT. Oxford, UK: IRL, 1987, 1-16.
30. Sampson JR, Dolwani S, Jones S, Eccles D, Ellis A, Evans DG, Frayling I, Jordan S, Maher ER, Mak T, Maynard J, Pigatto F, Shaw J, and Cheadle JP. Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. Lancet 362: 39-41, 2003.
31. Selfridge J, Shia KT, Redhead NJ, and Melton DW. Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene. Nucleic Acids Res 29: 4541-4550, 2001.
32. Sieber OM, Lipton L, Crabtree M, Heinimann K, Fidalgo P, Phillips RK, Bisgaard ML, Orntoft TF, Aaltonen LA, Hodgson SV, Thomas HJ, and Tomlinson IP. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med 348: 791-799, 2003.
33. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, and Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985.
34. Sugioka G, Porta EA, and Hartroft WS. Early changes in livers of rats fed choline-deficient diets at four levels of protein. Am J Pathol 57: 431-455, 1969.
35. Suliman HB, Carraway MS, and Piantadosi CA. Postlipopolysaccharide oxidative damage of mitochondrial DNA. Am J Respir Crit Care Med 167: 570-579, 2003.
36. Suliman HB, Carraway MS, Velsor LW, Day BJ, Ghio AJ, and Piantadosi CA. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Free Radic Biol Med 32: 246-256, 2002.
37. Szczesny B, Hazra TK, Papanconstantinour J, Mitra S, and Boldogh I. Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proc Natl Acad Sci USA 100: 10670-10675, 2003.
38. Van Loo G, Schotte P, van Gurp M, Demol H, Hoorelbeke B, Gevaert K, Rodriguez I, Ruiz-Carrillo A, Vandekerckhove J, Declercq W, Beyaert R, and Vandenabeele P. Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 8: 1136-1142, 2001.
39. Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, and Burnett JC Jr. Natriuretic peptide system in human heart failure. Circulation 88: 1004-1009, 1993.
40. Wei CM, Lerman A, Rodeheffer RJ, McGregor CG, Brandt RR, Wright S, Heublein DM, Kao PC, Edwards WD, and Burnett JC Jr. Endothelin in human congestive heart failure. Circulation 89: 1580-1586, 1994.
41. Wilson DM III, Tentler JJ, Carney JP, Wilson TM, and Kelley MR. Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats. Alcohol Clin Exp Res 18: 1267-1271, 1994.
42. Yamaguchi S, Shinmura K, Saitoh T, Takenoshita S, Kuwano H, and Yokota J. A single nucleotid polymorphism at the splice donor site of the human MYH base excision repair genes results in reduced translation efficiency of its transcripts. Genes Cells 7: 461-474, 2002.
43. Yang S, Koteish A, Lin H, Huang J, Roskams T, Dawson V, and Diehl AM. Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology 39: 403-411, 2004.
44. Yang SQ, Zhu H, Li Y, Lin HZ, Gabrielson K, Trush MA, and Diehl AM. Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 378: 259-268, 2000.