Rodent nutritional model of non-alcoholic steatohepatitis: Species, strain and sex difference studies

Journal of Gastroenterology and Hepatology (Australia)

Volumn 18, Issue 11, 2003, Pages 1272-1282

  Kirsch, Richard ^a,b   Clarkson, Vivian ^a   Shephard, Enid G ^a   Marais, David A ^a   Jaffer, Mohamed A ^a   Woodburne, Vivienne E ^a   Kirsch, Ralph E ^a   De La M Hall, Pauline ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Choline; Lipid; Lipid peroxidation; Methionine; Mice; Mitochondria; Non alcoholic steatohepatitis; Rats; Sex; Strain

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKADIENE; CHOLINE; LIPID; LIPID HYDROPEROXIDE; METHIONINE; TARTARIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY MASS; CELL DAMAGE; CLINICAL FEATURE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; FATTY LIVER; FEEDING; FEMALE; HEPATITIS; HISTOLOGY; INFLAMMATION; LIPID LIVER LEVEL; LIPID PEROXIDATION; LIVER DISEASE; LIVER FIBROSIS; LIVER NECROSIS; LIVER WEIGHT; MALE; MITOCHONDRION; MODEL; NONHUMAN; NUTRITION; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; RAT; RAT STRAIN; RODENT; SEX DIFFERENCE; SPECIES DIFFERENTIATION; STEATOHEPATITIS; STEATOSIS; STRAIN DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; ULTRASTRUCTURE;

EID: 0344010170     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2003.03198.x     Document Type: Article

References (46)

1. Byron D, Minuk CU. Profile of an urban hospital based practice. Hepatology 1996; 24: 813-15.
2. Clark JM, Brancati FL, Diehl AM. Nonalcoholic fatty liver disease. Gastroenterology 2002; 122: 1649-57.
3. Ludwig J, Viggiano TR, McGill DB, Ott BJ. Nonalcoholic steatohepatitis. Mayo Clinic Proc. 1980; 55: 434-8.
4. Hall P de la M. Alcoholic liver disease. In: MacSween RNM, Burt AD, Portman BC, Ishak KG, Scheuer PJ, Anthony PP, eds. Pathology of the Liver, 4th edn. Edinburgh: Churchill Livingstone, 2002; 273-311.
5. Eriksson S, Eriksson KF, Bondesson L. Nonalcoholic steatohepatitis in obesity: a reversible condition. Acta Med. Scand. 1986; 220: 83-8.
6. Itoh S, Yougel T, Kawagoe K. Comparison between non-alcoholic steatohepatitis and alcoholic hepatitis. Am. J. Gastroenterol. 1987; 82: 650-4.
7. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103-9.
8. Powell EE, Cooksley WGE, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis, a follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80.
9. Ludwig J, McGill DB, Lindor KD. Review: nonalcoholic steatohepatitis. J. Gastroenterol. Hepatol. 1997; 12: 398-403.
10. Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin. Liver Dis. 2001; 21: 89-104.
11. Farrell GC. Drugs and steatohepatitis. Semin. Liver Dis. 2002; 22: 185-94.
12. Koteish A, Diehl AM. Animal models of steatosis. Semin. Liver. Dis. 2001; 21: 57-70.
13. Teramoto K, Bowers JL, Khettry U, Palombo JD, Clouse ME. A rat fatty liver transplant model. Transplantation 1993; 55: 737-41.
14. Weltman MD, Farrell GC, Liddle C. Increased hepatocyte CYP2E1 expression in a rat nutritional model of steatosis with inflammation. Gastroenterology 1996; 111: 1645-53.
15. Leclercq IA, Farrell GC, Field J, Bell DR, Gonzales FJ, Robertson GR. Role of CYP2E1 and CYP4A enzymes as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis. J. Clin. Invest. 2000; 105: 1067-75.
16. Leclercq IA, Farrell GC, Schreimer PJ, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J. Hepatol. 2002; 37: 206-13.
17. Ip E, Robertson G, Hall P, Kirsch R, Farrell G, Leclercq I. Effects of altered lipid metabolism on the development of non-alcoholic steatohepatitis [Abstract]. Hepatology 2002; 36: 403A.
18. Pera N, Phung N, Leclercq I, Farrell GC, George J. Oxidative stress and the evolution of hepatic fibrogenesis in a rodent nutritional model of non-alcoholic steatohepatitis [Abstract]. J. Gastroenterol. Hepatol. 2001; 16 (Suppl.): A77.
19. Zhang B-H, Weltman M, Farrell GC. Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats. J. Gastroenterol. Hepatol. 1999; 14: 133-7.
20. Phung N, Farrell G, Robertson G, George G. Antioxidant therapy with Vitamin E ameliorates fibrosis in MCDD-associated NASH [Abstract]. J. Gastroenterol. Hepatol. 2001; 16 (Suppl.): A52.
21. Weltman MD, Farrell GC, Hall P de la M, Ingelman-Sundberg M, Liddle C. Hepatic cytochrome P4502E1 is increased in patients with non-alcoholic steatohepatitis. Hepatology 1998; 27: 128-33.
22. Sanyal AJ, Campbell-Sargent C, Mirshahi F et al. Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-92.
23. Struben VMD, Hespenheide EE, Caldwell SH. Non-alcoholic steatohepatitis and crytogenic cirrhosis within kindreds. Am. J. Med. 2000; 108: 9-13.
24. Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with non-alcoholic steatohepatitis. Hepatology 1999; 30: 1356-62.
25. Diehl AM, Goodman Z, Ishak KG. Alcohol-like liver disease in non-alcoholics. A clinical and histological comparison with alcohol induced liver injury. Gastroenterology 1988; 95: 1056-62.
26. Powell EE, Cooksley WG, Hanson R. The natural history of non-alcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80.
27. Lee RG. Non-alcoholic steatohepatitis: a study of 49 patients. Hum. Pathol. 1989; 20: 594-8.
28. Hørder M, Rej R. Alanine transaminase. In: Bergmeyer HU, Bergmeyer J, Grassl M, eds. Methods of Enzymatic Analysis, 3rd edn. Weinheim: Verlag-Chemie, 1983; 444-56.
29. Folch J, Lees M, Sloane-Stanley GA. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957; 226: 497-509.
30. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959; 37: 911-17.
31. McGowan MW, Artiss JD, Strandbergh DR, Zak B. A peroxidase coupled method for the colorimetric determination of serum triglycerides. Clin. Chem. 1983; 29: 538-42.
32. Vasankari T, Urho K, Oui H, Kapanen J, Markku A. Measurement of serum lipid peroxidation during exercise using three different methods: diene conjugation, thiobarbituric acid reactive material and fluorescent chromolipids. Clin. Chim. Acta 1995; 234: 63-9.
33. Jziang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein. Anal. Biochem. 1992; 202: 384-9.
34. Asakawa T, Matsushita S. Colouring conditions of thiobarbituric acid test for detecting lipid hydroperoxides. Lipids 1980; 15: 137-40.
35. Lowry OH, Rosebrough NJ, Farr AL, Randall RL. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951; 193: 265-76.
36. Caldwell SH, Swerdlow RH, Khan EM et al. Mitochondrial abnormalities in non-alcoholic steatohepatitis. J. Hepatol. 1999; 31: 430-4.
37. Ghoshal AK, Farber E. Choline defiency, lipotrope deficiency and the development of liver disease including cancer: a new perspective. Lab. Invest. 1993; 68: 255-60.
38. McGilvery RW, Goldstein GW. Amino acids: one-carbon pool and total balance. In: Biochemistry: a Functional Approach, Igaku-Shoin/Saunders International 3rd edn. Japan: WB Saunders, 1983; 628-37.
39. Lindblad L, Schersten T. Incorporation rate in vitro of choline and methyl-methionine into human lecithins. Scand. J. Gastroenterol. 1976; 11: 587-91.
40. Tessitore L, Secca E, Greco M, Pani P, Dianzani MU. Sexually differentiated response to choline in choline deficiency and ethionine intoxication. Int. J. Exp. Pathol. 1995; 76: 125-9.
41. Negishi I, Aizawa Y. Sex difference in the development of fatty liver by orotic acid. Jpn. J. Pharmacol. 1975; 25: 289-94.
42. Plummer JL, Hall P de la M, Jenner MA, Cousins MJ. Sex differences in halothane metabolism and hepatotoxicity in a rat-model. Anaesth. Analg. 1985; 64: 563-9.
43. Kato R. Sex-related differences in drug metabolism. Drug Metab. Rev. 1974; 3: 1-32.
44. Wilson K. Sex-related differences in drug disposition in man. Clin. Pharmacokinet. 1984; 9: 189-202.
45. Gourlay GK, Adams JF, Cousins MJ, Hall P de la M. Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains. Anaesthesiology 1981; 55: 96-103.
46. Rashid A, Wu T-C, Huang C-C et al. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 1999; 29: 1131-8.