Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

Nature Genetics

Volumn 46, Issue 4, 2014, Pages 345-351

  Holmen, Oddgeir L ^a,b   Zhang, He ^c   Fan, Yanbo ^c   Hovelson, Daniel H ^c   Schmidt, Ellen M ^c   Zhou, Wei ^c   Guo, Yanhong ^c   Zhang, Ji ^c   Langhammer, Arnulf ^a   Løchen, Maja Lisa ^d   Ganesh, Santhi K ^c   Vatten, Lars ^a   Skorpen, Frank ^a   Dalen, Håvard ^a,e   Zhang, Jifeng ^c   Pennathur, Subramaniam ^c   Chen, Jin ^c   Platou, Carl ^e   Mathiesen, Ellisiv B ^d,f   Wilsgaard, Tom ^d   Njølstad, Inger ^d   Boehnke, Michael ^g   Chen, Y Eugene ^c   Abecasis, Gonçalo R ^g   Hveem, Kristian ^a,e   Willer, Cristen J ^c   more..

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TROMSØ   (Norway)

^e Levanger Hospital   (Norway)

^f UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^g UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUTAMIC ACID; LIPID; LYSINE;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; EVALUATION STUDY; EXOME; GENE; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; NORWAY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TM6SF2 GENE;

MUS;

ANIMALS; CHOLESTEROL, LDL; EXOME; GENE KNOCKDOWN TECHNIQUES; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LIPIDS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MUTATION, MISSENSE; MYOCARDIAL INFARCTION; NORWAY; RISK FACTORS;

EID: 84898058547     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2926     Document Type: Article

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