-
1
-
-
84871036375
-
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010
-
Lozano, R.; Naghavi, M.; Foreman, K.; Lim, S.; Shibuya, K.; Aboyans, V.; Abraham, J.; Adair, T.; Aggarwal, R.; Ahn, S.Y.; et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010. Lancet 2012, 380, 2095–2128.
-
(2012)
Lancet
, vol.380
, pp. 2095-2128
-
-
Lozano, R.1
Naghavi, M.2
Foreman, K.3
Lim, S.4
Shibuya, K.5
Aboyans, V.6
Abraham, J.7
Adair, T.8
Aggarwal, R.9
Ahn, S.Y.10
-
2
-
-
84871099014
-
Disability-adjusted life years (Dalys) for 291 diseases and injuries in 21 regions, 1990–2010: A systematic analysis for the global burden of disease study 2010
-
Murray, C.J.L.; Vos, T.; Lozano, R.; Naghavi, M.; Flaxman, A.D.; Michaud, C.; Ezzati, M.; Shibuya, K.; Salomon, J.A.; Abdalla, S.; et al. Disability-adjusted life years (dalys) for 291 diseases and injuries in 21 regions, 1990–2010: A systematic analysis for the global burden of disease study 2010. Lancet 2012, 380, 2197–2223.
-
(2012)
Lancet
, vol.380
, pp. 2197-2223
-
-
Murray, C.J.L.1
Vos, T.2
Lozano, R.3
Naghavi, M.4
Flaxman, A.D.5
Michaud, C.6
Ezzati, M.7
Shibuya, K.8
Salomon, J.A.9
Abdalla, S.10
-
3
-
-
84875147483
-
-
British Heart Foundation: London, UK
-
Townsend, N.; Wickramasinghe, K.; Bhatnagar, P.; Smolina, K.; Nichols, M.; Leal, J.; Luengo-Fernandez, R.; Rayner, M. Coronary Heart Disease Statistics; British Heart Foundation: London, UK, 2012; pp. 1–206.
-
(2012)
Coronary Heart Disease Statistics
, pp. 1-206
-
-
Townsend, N.1
Wickramasinghe, K.2
Bhatnagar, P.3
Smolina, K.4
Nichols, M.5
Leal, J.6
Luengo-Fernandez, R.7
Rayner, M.8
-
4
-
-
84882808439
-
Meta-analysis of clinical outcomes of intravenous recombinant tissue plasminogen activator for acute ischemic stroke: Within 3 h versus 3–4.5 h
-
Li, B.-H.; Ding, X.; Yin, Y.-W.; Liu, Y.; Gao, C.-Y.; Zhang, L.-L.; Li, J.-C. Meta-analysis of clinical outcomes of intravenous recombinant tissue plasminogen activator for acute ischemic stroke: Within 3 h versus 3–4.5 h. Curr. Med. Res. Opin. 2013, 29, 1105–1114.
-
(2013)
Curr. Med. Res. Opin.
, vol.29
, pp. 1105-1114
-
-
Li, B.-H.1
Ding, X.2
Yin, Y.-W.3
Liu, Y.4
Gao, C.-Y.5
Zhang, L.-L.6
Li, J.-C.7
-
5
-
-
79959981013
-
Recombinant tissue-type plasminogen activator use for ischemic stroke in the united states: A doubling of treatment rates over the course of 5 years
-
Adeoye, O.; Hornung, R.; Khatri, P.; Kleindorfer, D. Recombinant tissue-type plasminogen activator use for ischemic stroke in the united states: A doubling of treatment rates over the course of 5 years. Stroke 2011, 42, 1952–1955.
-
(2011)
Stroke
, vol.42
, pp. 1952-1955
-
-
Adeoye, O.1
Hornung, R.2
Khatri, P.3
Kleindorfer, D.4
-
6
-
-
79952309760
-
Scaling of brain metabolism with a fixed energy budget per neuron: Implications for neuronal activity, plasticity and evolution
-
Herculano-Houzel, S. Scaling of brain metabolism with a fixed energy budget per neuron: Implications for neuronal activity, plasticity and evolution. PLoS One 2011, 6, e17514.
-
(2011)
Plos One
, vol.6
-
-
Herculano-Houzel, S.1
-
7
-
-
0021984524
-
Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells
-
Pauwels, P.J.; Opperdoes, F.R.; Trouet, A. Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells. J. Neurochem. 1985, 44, 143–148.
-
(1985)
J. Neurochem.
, vol.44
, pp. 143-148
-
-
Pauwels, P.J.1
Opperdoes, F.R.2
Trouet, A.3
-
8
-
-
65949121134
-
Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options
-
Uttara, B.; Singh, A.V.; Zamboni, P.; Mahajan, R.T. Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 2009, 7, 65–74.
-
(2009)
Curr. Neuropharmacol.
, vol.7
, pp. 65-74
-
-
Uttara, B.1
Singh, A.V.2
Zamboni, P.3
Mahajan, R.T.4
-
9
-
-
84864330120
-
NADPH oxidases as therapeutic targets in ischemic stroke
-
Kahles, T.; Brandes, R.P. NADPH oxidases as therapeutic targets in ischemic stroke. Cell. Mol. Life Sci. 2012, 69, 2345–2363.
-
(2012)
Cell. Mol. Life Sci.
, vol.69
, pp. 2345-2363
-
-
Kahles, T.1
Brandes, R.P.2
-
10
-
-
84872486948
-
Molecular mechanisms of ischemia-reperfusion injury in brain: Pivotal role of the mitochondrial membrane potential in reactive oxygen species generation
-
Sanderson, T.H.; Reynolds, C.A.; Kumar, R.; Przyklenk, K.; Huttemann, M. Molecular mechanisms of ischemia-reperfusion injury in brain: Pivotal role of the mitochondrial membrane potential in reactive oxygen species generation. Mol. Neurobiol. 2013, 47, 9–23.
-
(2013)
Mol. Neurobiol.
, vol.47
, pp. 9-23
-
-
Sanderson, T.H.1
Reynolds, C.A.2
Kumar, R.3
Przyklenk, K.4
Huttemann, M.5
-
11
-
-
84871607234
-
Xanthine oxidase contributes to mitochondrial ros generation in an experimental model of cocaine-induced diastolic dysfunction
-
Vergeade, A.; Mulder, P.; Vendeville, C.; Ventura-Clapier, R.; Thuillez, C.; Monteil, C. Xanthine oxidase contributes to mitochondrial ros generation in an experimental model of cocaine-induced diastolic dysfunction. J. Cardiovasc. Pharmacol. 2012, 60, 538–543.
-
(2012)
J. Cardiovasc. Pharmacol.
, vol.60
, pp. 538-543
-
-
Vergeade, A.1
Mulder, P.2
Vendeville, C.3
Ventura-Clapier, R.4
Thuillez, C.5
Monteil, C.6
-
12
-
-
79960543076
-
H2O2: A dynamic neuromodulator
-
Rice, M.E. H2O2: A dynamic neuromodulator. Neuroscientist 2011, 17, 389–406.
-
(2011)
Neuroscientist
, vol.17
, pp. 389-406
-
-
Rice, M.E.1
-
13
-
-
1542376859
-
Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats
-
Liu, S.; Shi, H.; Liu, W.; Furuichi, T.; Timmins, G.S.; Liu, K.J. Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 2004, 24, 343–349.
-
(2004)
J. Cereb. Blood Flow Metab.
, vol.24
, pp. 343-349
-
-
Liu, S.1
Shi, H.2
Liu, W.3
Furuichi, T.4
Timmins, G.S.5
Liu, K.J.6
-
14
-
-
0032880761
-
Acidosis potentiates oxidative neuronal death by multiple mechanisms
-
Ying, W.; Han, S.K.; Miller, J.W.; Swanson, R.A. Acidosis potentiates oxidative neuronal death by multiple mechanisms. J. Neurochem. 1999, 73, 1549–1556.
-
(1999)
J. Neurochem.
, vol.73
, pp. 1549-1556
-
-
Ying, W.1
Han, S.K.2
Miller, J.W.3
Swanson, R.A.4
-
15
-
-
84860669170
-
Comparative impact of voltage-gated calcium channels and nmda receptors on mitochondria-mediated neuronal injury
-
Stanika, R.I.; Villanueva, I.; Kazanina, G.; Andrews, S.B.; Pivovarova, N.B. Comparative impact of voltage-gated calcium channels and nmda receptors on mitochondria-mediated neuronal injury. J. Neurosci. 2012, 32, 6642–6650.
-
(2012)
J. Neurosci.
, vol.32
, pp. 6642-6650
-
-
Stanika, R.I.1
Villanueva, I.2
Kazanina, G.3
Andrews, S.B.4
Pivovarova, N.B.5
-
16
-
-
0345735607
-
Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke
-
Yamato, M.; Egashira, T.; Utsumi, H. Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke. Free Radic. Biol. Med. 2003, 35, 1619–1631.
-
(2003)
Free Radic. Biol. Med.
, vol.35
, pp. 1619-1631
-
-
Yamato, M.1
Egashira, T.2
Utsumi, H.3
-
17
-
-
0031942539
-
Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat
-
Peters, O.; Back, T.; Lindauer, U.; Busch, C.; Megow, D.; Dreier, J.; Dirnagl, U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 1998, 18, 196–205.
-
(1998)
J. Cereb. Blood Flow Metab.
, vol.18
, pp. 196-205
-
-
Peters, O.1
Back, T.2
Lindauer, U.3
Busch, C.4
Megow, D.5
Dreier, J.6
Dirnagl, U.7
-
18
-
-
39549102405
-
Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
-
Chen, Q.; Moghaddas, S.; Hoppel, C.L.; Lesnefsky, E.J. Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria. Am. J. Physiol. Cell. Physiol. 2008, 294, C460–C466.
-
(2008)
Am. J. Physiol. Cell. Physiol.
, vol.294
, pp. C460-C466
-
-
Chen, Q.1
Moghaddas, S.2
Hoppel, C.L.3
Lesnefsky, E.J.4
-
19
-
-
84857508603
-
The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice
-
Niatsetskaya, Z.V.; Sosunov, S.A.; Matsiukevich, D.; Utkina-Sosunova, I.V.; Ratner, V.I.; Starkov, A.A.; Ten, V.S. The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice. J. Neurosci. 2012, 32, 3235–3244.
-
(2012)
J. Neurosci.
, vol.32
, pp. 3235-3244
-
-
Niatsetskaya, Z.V.1
Sosunov, S.A.2
Matsiukevich, D.3
Utkina-Sosunova, I.V.4
Ratner, V.I.5
Starkov, A.A.6
Ten, V.S.7
-
20
-
-
84880253528
-
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
-
Chouchani, E.T.; Methner, C.; Nadtochiy, S.M.; Logan, A.; Pell, V.R.; Ding, S.; James, A.M.; Cocheme, H.M.; Reinhold, J.; Lilley, K.S.; et al. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat. Med. 2013, 19, 753–759.
-
(2013)
Nat. Med.
, vol.19
, pp. 753-759
-
-
Chouchani, E.T.1
Methner, C.2
Nadtochiy, S.M.3
Logan, A.4
Pell, V.R.5
Ding, S.6
James, A.M.7
Cocheme, H.M.8
Reinhold, J.9
Lilley, K.S.10
-
21
-
-
67649852282
-
Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion
-
Chen, H.; Song, Y.S.; Chan, P.H. Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J. Cereb. Blood Flow Metab. 2009, 29, 1262–1272.
-
(2009)
J. Cereb. Blood Flow Metab.
, vol.29
, pp. 1262-1272
-
-
Chen, H.1
Song, Y.S.2
Chan, P.H.3
-
22
-
-
0347711117
-
NADPH oxidases: Not just for leukocytes anymore!
-
Bokoch, G.M.; Knaus, U.G. NADPH oxidases: Not just for leukocytes anymore! Trends Biochem. Sci. 2003, 28, 502–508.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 502-508
-
-
Bokoch, G.M.1
Knaus, U.G.2
-
23
-
-
4544274760
-
Nox3 regulation by NOXO1, p47phox, and p67phox
-
Cheng, G.; Ritsick, D.; Lambeth, J.D. Nox3 regulation by NOXO1, p47phox, and p67phox. J. Biol. Chem. 2004, 279, 34250–34255.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34250-34255
-
-
Cheng, G.1
Ritsick, D.2
Lambeth, J.D.3
-
24
-
-
84874242635
-
Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy
-
Matsushima, S.; Kuroda, J.; Ago, T.; Zhai, P.; Park, J.Y.; Xie, L.H.; Tian, B.; Sadoshima, J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circ. Res. 2013, 112, 651–663.
-
(2013)
Circ. Res.
, vol.112
, pp. 651-663
-
-
Matsushima, S.1
Kuroda, J.2
Ago, T.3
Zhai, P.4
Park, J.Y.5
Xie, L.H.6
Tian, B.7
Sadoshima, J.8
-
25
-
-
0019440515
-
Superoxide radicals in feline intestinal ischemia
-
Granger, D.N.; Rutili, G.; McCord, J.M. Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981, 81, 22–29.
-
(1981)
Gastroenterology
, vol.81
, pp. 22-29
-
-
Granger, D.N.1
Rutili, G.2
McCord, J.M.3
-
26
-
-
0022502428
-
Xanthine oxidase: Biochemistry, distribution and physiology
-
Parks, D.A.; Granger, D.N. Xanthine oxidase: Biochemistry, distribution and physiology. Acta Physiol. Scand. Suppl. 1986, 548, 87–99.
-
(1986)
Acta Physiol. Scand. Suppl.
, vol.548
, pp. 87-99
-
-
Parks, D.A.1
Granger, D.N.2
-
27
-
-
18844412788
-
Reactive oxygen species and the modulation of stroke
-
Crack, P.J.; Taylor, J.M. Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med. 2005, 38, 1433–1444.
-
(2005)
Free Radic. Biol. Med.
, vol.38
, pp. 1433-1444
-
-
Crack, P.J.1
Taylor, J.M.2
-
28
-
-
2542551340
-
Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia
-
Gursoy-Ozdemir, Y.; Can, A.; Dalkara, T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 2004, 35, 1449–1453.
-
(2004)
Stroke
, vol.35
, pp. 1449-1453
-
-
Gursoy-Ozdemir, Y.1
Can, A.2
Dalkara, T.3
-
29
-
-
0026443488
-
Oxygen radicals in cerebral ischemia
-
Nelson, C.W.; Wei, E.P.; Povlishock, J.T.; Kontos, H.A.; Moskowitz, M.A. Oxygen radicals in cerebral ischemia. Am. J. Physiol. 1992, 263, H1356–H1362.
-
(1992)
Am. J. Physiol
, vol.263
, pp. H1356-H1362
-
-
Nelson, C.W.1
Wei, E.P.2
Povlishock, J.T.3
Kontos, H.A.4
Moskowitz, M.A.5
-
30
-
-
0033756824
-
The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes
-
McCracken, E.; Valeriani, V.; Simpson, C.; Jover, T.; McCulloch, J.; Dewar, D. The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes. J. Cereb. Blood Flow Metab. 2000, 20, 1529–1536.
-
(2000)
J. Cereb. Blood Flow Metab.
, vol.20
, pp. 1529-1536
-
-
McCracken, E.1
Valeriani, V.2
Simpson, C.3
Jover, T.4
McCulloch, J.5
Dewar, D.6
-
31
-
-
67349099098
-
Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats
-
Matsuda, S.; Umeda, M.; Uchida, H.; Kato, H.; Araki, T. Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats. J. Neural Transm. 2009, 116, 395–404.
-
(2009)
J. Neural Transm.
, vol.116
, pp. 395-404
-
-
Matsuda, S.1
Umeda, M.2
Uchida, H.3
Kato, H.4
Araki, T.5
-
32
-
-
0029973192
-
Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion
-
Liu, P.K.; Hsu, C.Y.; Dizdaroglu, M.; Floyd, R.A.; Kow, Y.W.; Karakaya, A.; Rabow, L.E.; Cui, J.K. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion. J. Neurosci. 1996, 16, 6795–6806.
-
(1996)
J. Neurosci.
, vol.16
, pp. 6795-6806
-
-
Liu, P.K.1
Hsu, C.Y.2
Dizdaroglu, M.3
Floyd, R.A.4
Kow, Y.W.5
Karakaya, A.6
Rabow, L.E.7
Cui, J.K.8
-
33
-
-
0030943111
-
Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death
-
Chen, J.; Jin, K.; Chen, M.; Pei, W.; Kawaguchi, K.; Greenberg, D.A.; Simon, R.P. Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death. J. Neurochem. 1997, 69, 232–245.
-
(1997)
J. Neurochem.
, vol.69
, pp. 232-245
-
-
Chen, J.1
Jin, K.2
Chen, M.3
Pei, W.4
Kawaguchi, K.5
Greenberg, D.A.6
Simon, R.P.7
-
34
-
-
0034068520
-
Activation of poly(Adp-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia
-
Nagayama, T.; Simon, R.P.; Chen, D.; Henshall, D.C.; Pei, W.; Stetler, R.A.; Chen, J. Activation of poly(adp-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia. J. Neurochem. 2000, 74, 1636–1645.
-
(2000)
J. Neurochem.
, vol.74
, pp. 1636-1645
-
-
Nagayama, T.1
Simon, R.P.2
Chen, D.3
Henshall, D.C.4
Pei, W.5
Stetler, R.A.6
Chen, J.7
-
35
-
-
0032909814
-
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: Implication of the failure of DNA repair in neuronal apoptosis
-
Kawase, M.; Fujimura, M.; Morita-Fujimura, Y.; Chan, P.H. Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: Implication of the failure of DNA repair in neuronal apoptosis. Stroke 1999, 30, 441–449.
-
(1999)
Stroke
, vol.30
, pp. 441-449
-
-
Kawase, M.1
Fujimura, M.2
Morita-Fujimura, Y.3
Chan, P.H.4
-
36
-
-
0036703753
-
A bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death
-
Kirkland, R.A.; Windelborn, J.A.; Kasprzak, J.M.; Franklin, J.L. A bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death. J. Neurosci. 2002, 22, 6480–6490.
-
(2002)
J. Neurosci.
, vol.22
, pp. 6480-6490
-
-
Kirkland, R.A.1
Windelborn, J.A.2
Kasprzak, J.M.3
Franklin, J.L.4
-
37
-
-
0036883891
-
Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release
-
Sugawara, T.; Lewen, A.; Gasche, Y.; Yu, F.; Chan, P.H. Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release. FASEB J. 2002, 16, 1997–1999.
-
(2002)
FASEB J
, vol.16
, pp. 1997-1999
-
-
Sugawara, T.1
Lewen, A.2
Gasche, Y.3
Yu, F.4
Chan, P.H.5
-
38
-
-
0025831476
-
Calcium-activated neutral protease (Calpain) system: Structure, function, and regulation
-
Croall, D.E.; DeMartino, G.N. Calcium-activated neutral protease (calpain) system: Structure, function, and regulation. Physiol. Rev. 1991, 71, 813–847.
-
(1991)
Physiol. Rev.
, vol.71
, pp. 813-847
-
-
Croall, D.E.1
Demartino, G.N.2
-
39
-
-
0035853767
-
Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling
-
Scorrano, L.; Penzo, D.; Petronilli, V.; Pagano, F.; Bernardi, P. Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling. J. Biol. Chem. 2001, 276, 12035–12040.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 12035-12040
-
-
Scorrano, L.1
Penzo, D.2
Petronilli, V.3
Pagano, F.4
Bernardi, P.5
-
40
-
-
0031888955
-
A caspase-activated dnase that degrades DNA during apoptosis, and its inhibitor icad
-
Enari, M.; Sakahira, H.; Yokoyama, H.; Okawa, K.; Iwamatsu, A.; Nagata, S. A caspase-activated dnase that degrades DNA during apoptosis, and its inhibitor icad. Nature 1998, 391, 43–50.
-
(1998)
Nature
, vol.391
, pp. 43-50
-
-
Enari, M.1
Sakahira, H.2
Yokoyama, H.3
Okawa, K.4
Iwamatsu, A.5
Nagata, S.6
-
41
-
-
0040298568
-
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
-
Jänicke, R.U.; Sprengart, M.L.; Wati, M.R.; Porter, A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 1998, 273, 9357–9360.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9357-9360
-
-
Jänicke, R.U.1
Sprengart, M.L.2
Wati, M.R.3
Porter, A.G.4
-
42
-
-
40049091482
-
The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme
-
Hanus, J.; Kalinowska-Herok, M.; Widlak, P. The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme. Apoptosis 2008, 13, 377–382.
-
(2008)
Apoptosis
, vol.13
, pp. 377-382
-
-
Hanus, J.1
Kalinowska-Herok, M.2
Widlak, P.3
-
43
-
-
0034677931
-
Cleavage preferences of the apoptotic endonuclease DFF40 (Caspase-activated dnase or nuclease) on naked DNA and chromatin substrates
-
Widlak, P.; Li, P.; Wang, X.; Garrard, W.T. Cleavage preferences of the apoptotic endonuclease DFF40 (caspase-activated dnase or nuclease) on naked DNA and chromatin substrates. J. Biol. Chem. 2000, 275, 8226–8232.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8226-8232
-
-
Widlak, P.1
Li, P.2
Wang, X.3
Garrard, W.T.4
-
44
-
-
0032900585
-
Regulation of gene expression by reactive oxygen
-
Dalton, T.P.; Shertzer, H.G.; Puga, A. Regulation of gene expression by reactive oxygen. Annu. Rev. Pharmacol. Toxicol. 1999, 39, 67–101.
-
(1999)
Annu. Rev. Pharmacol. Toxicol.
, vol.39
, pp. 67-101
-
-
Dalton, T.P.1
Shertzer, H.G.2
Puga, A.3
-
45
-
-
77954624383
-
Regulation of the expression of inducible nitric oxide synthase
-
Pautz, A.; Art, J.; Hahn, S.; Nowag, S.; Voss, C.; Kleinert, H. Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide 2010, 23, 75–93.
-
(2010)
Nitric Oxide
, vol.23
, pp. 75-93
-
-
Pautz, A.1
Art, J.2
Hahn, S.3
Nowag, S.4
Voss, C.5
Kleinert, H.6
-
46
-
-
77955850553
-
Ischemic preconditioning mediates cyclooxygenase-2 expression via nuclear factor-kappa B activation in mixed cortical neuronal cultures
-
Kim, E.J.; Raval, A.P.; Hirsch, N.; Perez-Pinzon, M.A. Ischemic preconditioning mediates cyclooxygenase-2 expression via nuclear factor-kappa B activation in mixed cortical neuronal cultures. Transl. Stroke Res. 2010, 1, 40–47.
-
(2010)
Transl. Stroke Res.
, vol.1
, pp. 40-47
-
-
Kim, E.J.1
Raval, A.P.2
Hirsch, N.3
Perez-Pinzon, M.A.4
-
47
-
-
78649716241
-
Transforming growth factor-beta1 induces matrix metalloproteinase-9 and cell migration in astrocytes: Roles of ros-dependent ERK- and JNK-NF-kappaB pathways
-
Hsieh, H.L.; Wang, H.H.; Wu, W.B.; Chu, P.J.; Yang, C.M. Transforming growth factor-beta1 induces matrix metalloproteinase-9 and cell migration in astrocytes: Roles of ros-dependent ERK- and JNK-NF-kappaB pathways. J. Neuroinflamm. 2010, 7, 88.
-
(2010)
J. Neuroinflamm.
, vol.7
, pp. 88
-
-
Hsieh, H.L.1
Wang, H.H.2
Wu, W.B.3
Chu, P.J.4
Yang, C.M.5
-
48
-
-
84877574716
-
Prostaglandin e(2)-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd
-
Park, T.Y.; Baik, E.J.; Lee, S.H. Prostaglandin e(2)-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd.3 brain endothelial cells. Br. J. Pharmacol. 2013, 169, 604–618.
-
(2013)
Br. J. Pharmacol.
, vol.169
, Issue.3
, pp. 604-618
-
-
Park, T.Y.1
Baik, E.J.2
Lee, S.H.3
-
49
-
-
0035968287
-
Novel role for JNK as a stress-activated Bcl2 kinase
-
Deng, X.; Xiao, L.; Lang, W.; Gao, F.; Ruvolo, P.; May, W.S., Jr. Novel role for JNK as a stress-activated Bcl2 kinase. J. Biol. Chem. 2001, 276, 23681–23688.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23681-23688
-
-
Deng, X.1
Xiao, L.2
Lang, W.3
Gao, F.4
Ruvolo, P.5
May, W.S.6
-
50
-
-
0035735754
-
Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy
-
Fan, M.; Chambers, T.C. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist. Updat 2001, 4, 253–267.
-
(2001)
Drug Resist. Updat
, vol.4
, pp. 253-267
-
-
Fan, M.1
Chambers, T.C.2
-
51
-
-
59049090581
-
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution
-
Soberanes, S.; Urich, D.; Baker, C.M.; Burgess, Z.; Chiarella, S.E.; Bell, E.L.; Ghio, A.J.; de Vizcaya-Ruiz, A.; Liu, J.; Ridge, K.M. et al. Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J. Biol. Chem. 2009, 284, 2176–2186.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 2176-2186
-
-
Soberanes, S.1
Urich, D.2
Baker, C.M.3
Burgess, Z.4
Chiarella, S.E.5
Bell, E.L.6
Ghio, A.J.7
De Vizcaya-Ruiz, A.8
Liu, J.9
Ridge, K.M.10
-
52
-
-
0030791228
-
The blood-brain barrier in neuroinflammatory diseases
-
De Vries, H.E.; Kuiper, J.; de Boer, A.G.; van Berkel, T.J.; Breimer, D.D. The blood-brain barrier in neuroinflammatory diseases. Pharmacol. Rev. 1997, 49, 143–155.
-
(1997)
Pharmacol. Rev
, vol.49
, pp. 143-155
-
-
De Vries, H.E.1
Kuiper, J.2
De Boer, A.G.3
Van Berkel, T.J.4
Breimer, D.D.5
-
54
-
-
0033862478
-
Serial mri after transient focal cerebral ischemia in rats: Dynamics of tissue injury, blood-brain barrier damage, and edema formation
-
Neumann-Haefelin, T.; Kastrup, A.; de Crespigny, A.; Yenari, M.A.; Ringer, T.; Sun, G.H.; Moseley, M.E. Serial mri after transient focal cerebral ischemia in rats: Dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke 2000, 31, 1965–1973.
-
Stroke
, vol.2000
, pp. 31
-
-
Neumann-Haefelin, T.1
Kastrup, A.2
De Crespigny, A.3
Yenari, M.A.4
Ringer, T.5
Sun, G.H.6
Moseley, M.E.7
-
55
-
-
41149090849
-
Mmp-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke
-
Rosell, A.; Cuadrado, E.; Ortega-Aznar, A.; Hernández-Guillamon, M.; Lo, E.H.; Montaner, J. Mmp-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke 2008, 39, 1121–1126.
-
(2008)
Stroke
, vol.39
, pp. 1121-1126
-
-
Rosell, A.1
Cuadrado, E.2
Ortega-Aznar, A.3
Hernández-Guillamon, M.4
Lo, E.H.5
Montaner, J.6
-
56
-
-
36849065421
-
Il-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-β, NF-κB, and AP-1 activation
-
Cortez, D.M.; Feldman, M.D.; Mummidi, S.; Valente, A.J.; Steffensen, B.; Vincenti, M.; Barnes, J.L.; Chandrasekar, B. Il-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-β, NF-κB, and AP-1 activation. Am. J. Physiol. Heart Circ. Physiol. 2007, 293, H3356–H3365.
-
(2007)
Am. J. Physiol. Heart Circ. Physiol
, vol.293
, pp. H3356-H3365
-
-
Cortez, D.M.1
Feldman, M.D.2
Mummidi, S.3
Valente, A.J.4
Steffensen, B.5
Vincenti, M.6
Barnes, J.L.7
Chandrasekar, B.8
-
57
-
-
0036084919
-
Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation
-
Mark, K.S.; Davis, T.P. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 2002, 282, H1485–H1494.
-
(2002)
Am. J. Physiol. Heart Circ. Physiol
, vol.282
, pp. H1485-H1494
-
-
Mark, K.S.1
Davis, T.P.2
-
58
-
-
0034977693
-
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression
-
Huber, J.D.; Witt, K.A.; Hom, S.; Egleton, R.D.; Mark, K.S.; Davis, T.P. Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression. Am. J. Physiol. Heart Circ. Physiol. 2001, 280, H1241–H1248.
-
(2001)
Am. J. Physiol. Heart Circ. Physiol
, vol.280
, pp. H1241-H1248
-
-
Huber, J.D.1
Witt, K.A.2
Hom, S.3
Egleton, R.D.4
Mark, K.S.5
Davis, T.P.6
-
59
-
-
9644259030
-
Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide
-
Yamagata, K.; Tagami, M.; Takenaga, F.; Yamori, Y.; Itoh, S. Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide. Neurobiol. Dis. 2004, 17, 491–499.
-
(2004)
Neurobiol. Dis.
, vol.17
, pp. 491-499
-
-
Yamagata, K.1
Tagami, M.2
Takenaga, F.3
Yamori, Y.4
Itoh, S.5
-
60
-
-
0028093281
-
Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding
-
Pokutta, S.; Herrenknecht, K.; Kemler, R.; Engel, J. Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur. J. Biochem. 1994, 223, 1019–1026.
-
(1994)
Eur. J. Biochem.
, vol.223
, pp. 1019-1026
-
-
Pokutta, S.1
Herrenknecht, K.2
Kemler, R.3
Engel, J.4
-
61
-
-
2542501568
-
Transcellular transport as a mechanism of blood-brain barrier disruption during stroke
-
Cipolla, M.J.; Crete, R.; Vitullo, L.; Rix, R.D. Transcellular transport as a mechanism of blood-brain barrier disruption during stroke. Front. Biosci. 2004, 9, 777–785.
-
(2004)
Front. Biosci.
, vol.9
, pp. 777-785
-
-
Cipolla, M.J.1
Crete, R.2
Vitullo, L.3
Rix, R.D.4
-
62
-
-
23244447749
-
Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier
-
Xu, H.; Dawson, R.; Crane, I.J.; Liversidge, J. Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier. Investig. Ophthalmol. Vis. Sci. 2005, 46, 2487–2494.
-
(2005)
Investig. Ophthalmol. Vis. Sci.
, vol.46
, pp. 2487-2494
-
-
Xu, H.1
Dawson, R.2
Crane, I.J.3
Liversidge, J.4
-
63
-
-
33846380363
-
Peri)vascular production and action of pro-inflammatory cytokines in brain pathology
-
Konsman, J.P.; Drukarch, B.; van Dam, A.M. (Peri)vascular production and action of pro-inflammatory cytokines in brain pathology. Clin. Sci. 2007, 112, 1–25.
-
(2007)
Clin. Sci
, vol.112
, pp. 1-25
-
-
Konsman, J.P.1
Drukarch, B.2
Van Dam, A.M.3
-
64
-
-
77954313737
-
Complement activation on platelets: Implications for vascular inflammation and thrombosis
-
Peerschke, E.I.; Yin, W.; Ghebrehiwet, B. Complement activation on platelets: Implications for vascular inflammation and thrombosis. Mol. Immunol. 2010, 47, 2170–2175.
-
(2010)
Mol. Immunol.
, vol.47
, pp. 2170-2175
-
-
Peerschke, E.I.1
Yin, W.2
Ghebrehiwet, B.3
-
65
-
-
0030030124
-
Hypoxia-induced exocytosis of endothelial cell weibel-palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation
-
Pinsky, D.J.; Naka, Y.; Liao, H.; Oz, M.C.; Wagner, D.D.; Mayadas, T.N.; Johnson, R.C.; Hynes, R.O.; Heath, M.; Lawson, C.A.; et al. Hypoxia-induced exocytosis of endothelial cell weibel-palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J. Clin. Investig. 1996, 97, 493–500.
-
(1996)
J. Clin. Investig.
, vol.97
, pp. 493-500
-
-
Pinsky, D.J.1
Naka, Y.2
Liao, H.3
Oz, M.C.4
Wagner, D.D.5
Mayadas, T.N.6
Johnson, R.C.7
Hynes, R.O.8
Heath, M.9
Lawson, C.A.10
-
66
-
-
77954482190
-
Leukocyte recruitment and ischemic brain injury
-
Yilmaz, G.; Granger, D.N. Leukocyte recruitment and ischemic brain injury. Neuromol. Med. 2010, 12, 193–204.
-
(2010)
Neuromol. Med.
, vol.12
, pp. 193-204
-
-
Yilmaz, G.1
Granger, D.N.2
-
67
-
-
34447116875
-
The phosphorylation state of enos modulates vascular reactivity and outcome of cerebral ischemia in vivo
-
Atochin, D.N.; Wang, A.; Liu, V.W.; Critchlow, J.D.; Dantas, A.P.; Looft-Wilson, R.; Murata, T.; Salomone, S.; Shin, H.K.; Ayata, C.; et al. The phosphorylation state of enos modulates vascular reactivity and outcome of cerebral ischemia in vivo. J. Clin. Investig. 2007, 117, 1961–1967.
-
(2007)
J. Clin. Investig.
, vol.117
, pp. 1961-1967
-
-
Atochin, D.N.1
Wang, A.2
Liu, V.W.3
Critchlow, J.D.4
Dantas, A.P.5
Looft-Wilson, R.6
Murata, T.7
Salomone, S.8
Shin, H.K.9
Ayata, C.10
-
68
-
-
0025947863
-
Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons
-
Del Zoppo, G.J.; Schmid-Schonbein, G.W.; Mori, E.; Copeland, B.R.; Chang, C.M. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 1991, 22, 1276–1283.
-
(1991)
Stroke
, vol.22
, pp. 1276-1283
-
-
Del Zoppo, G.J.1
Schmid-Schonbein, G.W.2
Mori, E.3
Copeland, B.R.4
Chang, C.M.5
-
69
-
-
24144447012
-
ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia
-
Melani, A.; Turchi, D.; Vannucchi, M.G.; Cipriani, S.; Gianfriddo, M.; Pedata, F. ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem. Int. 2005, 47, 442–448.
-
(2005)
Neurochem. Int.
, vol.47
, pp. 442-448
-
-
Melani, A.1
Turchi, D.2
Vannucchi, M.G.3
Cipriani, S.4
Gianfriddo, M.5
Pedata, F.6
-
70
-
-
3242673859
-
Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts
-
Korcok, J.; Raimundo, L.N.; Ke, H.Z.; Sims, S.M.; Dixon, S.J. Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts. J. Bone Miner. Res. 2004, 19, 642–651.
-
(2004)
J. Bone Miner. Res.
, vol.19
, pp. 642-651
-
-
Korcok, J.1
Raimundo, L.N.2
Ke, H.Z.3
Sims, S.M.4
Dixon, S.J.5
-
71
-
-
34547680192
-
CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4
-
Lyons, A.; Downer, E.J.; Crotty, S.; Nolan, Y.M.; Mills, K.H.; Lynch, M.A. CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4. J. Neurosci. 2007, 27, 8309–8313.
-
(2007)
J. Neurosci.
, vol.27
, pp. 8309-8313
-
-
Lyons, A.1
Downer, E.J.2
Crotty, S.3
Nolan, Y.M.4
Mills, K.H.5
Lynch, M.A.6
-
72
-
-
52549109505
-
Role of CX3CR1 (Fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse
-
Denes, A.; Ferenczi, S.; Halasz, J.; Kornyei, Z.; Kovacs, K.J. Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse. J. Cereb. Blood Flow Metab. 2008, 28, 1707–1721.
-
(2008)
J. Cereb. Blood Flow Metab.
, vol.28
, pp. 1707-1721
-
-
Denes, A.1
Ferenczi, S.2
Halasz, J.3
Kornyei, Z.4
Kovacs, K.J.5
-
73
-
-
78649526394
-
Sterile inflammation: Sensing and reacting to damage
-
Chen, G.Y.; Nunez, G. Sterile inflammation: Sensing and reacting to damage. Nat. Rev. Immunol. 2010, 10, 826–837.
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 826-837
-
-
Chen, G.Y.1
Nunez, G.2
-
74
-
-
59349116736
-
Toll-like receptor signaling in endogenous neuroprotection and stroke
-
Marsh, B.J.; Williams-Karnesky, R.L.; Stenzel-Poore, M.P. Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience 2009, 158, 1007–1020.
-
(2009)
Neuroscience
, vol.158
, pp. 1007-1020
-
-
Marsh, B.J.1
Williams-Karnesky, R.L.2
Stenzel-Poore, M.P.3
-
75
-
-
0032440899
-
Free radicals as mediators of neuronal injury
-
Facchinetti, F.; Dawson, V.L.; Dawson, T.M. Free radicals as mediators of neuronal injury. Cell. Mol. Neurobiol. 1998, 18, 667–682.
-
(1998)
Cell. Mol. Neurobiol.
, vol.18
, pp. 667-682
-
-
Facchinetti, F.1
Dawson, V.L.2
Dawson, T.M.3
-
76
-
-
22544462551
-
Antioxidant strategies in the treatment of stroke
-
Margaill, I.; Plotkine, M.; Lerouet, D. Antioxidant strategies in the treatment of stroke. Free Radic. Biol. Med. 2005, 39, 429–443.
-
(2005)
Free Radic. Biol. Med.
, vol.39
, pp. 429-443
-
-
Margaill, I.1
Plotkine, M.2
Lerouet, D.3
-
77
-
-
34547858520
-
Apocynin attenuates cerebral infarction after transient focal ischaemia in rats
-
Tang, L.L.; Ye, K.; Yang, X.F.; Zheng, J.S. Apocynin attenuates cerebral infarction after transient focal ischaemia in rats. J. Int. Med. Res. 2007, 35, 517–522.
-
(2007)
J. Int. Med. Res.
, vol.35
, pp. 517-522
-
-
Tang, L.L.1
Ye, K.2
Yang, X.F.3
Zheng, J.S.4
-
78
-
-
79151470304
-
Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats
-
Genovese, T.; Mazzon, E.; Paterniti, I.; Esposito, E.; Bramanti, P.; Cuzzocrea, S. Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats. Brain Res. 2011, 1372, 92–102.
-
(2011)
Brain Res
, vol.1372
, pp. 92-102
-
-
Genovese, T.1
Mazzon, E.2
Paterniti, I.3
Esposito, E.4
Bramanti, P.5
Cuzzocrea, S.6
-
79
-
-
49349093647
-
Early increase of NOX4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats
-
McCann, S.K.; Dusting, G.J.; Roulston, C.L. Early increase of NOX4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats. J. Neurosci. Res. 2008, 86, 2524–2534.
-
(2008)
J. Neurosci. Res.
, vol.86
, pp. 2524-2534
-
-
McCann, S.K.1
Dusting, G.J.2
Roulston, C.L.3
-
80
-
-
79952192922
-
NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia
-
Yoshioka, H.; Niizuma, K.; Katsu, M.; Okami, N.; Sakata, H.; Kim, G.S.; Narasimhan, P.; Chan, P.H. NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia. J. Cereb. Blood Flow Metab. 2011, 31, 868–880.
-
(2011)
J. Cereb. Blood Flow Metab.
, vol.31
, pp. 868-880
-
-
Yoshioka, H.1
Niizuma, K.2
Katsu, M.3
Okami, N.4
Sakata, H.5
Kim, G.S.6
Narasimhan, P.7
Chan, P.H.8
-
81
-
-
34547850670
-
NOX4 activity is determined by MRNA levels and reveals a unique pattern of ros generation
-
Serrander, L.; Cartier, L.; Bedard, K.; Banfi, B.; Lardy, B.; Plastre, O.; Sienkiewicz, A.; Forro, L.; Schlegel, W.; Krause, K.H. NOX4 activity is determined by MRNA levels and reveals a unique pattern of ros generation. Biochem. J. 2007, 406, 105–114.
-
(2007)
Biochem. J.
, vol.406
, pp. 105-114
-
-
Serrander, L.1
Cartier, L.2
Bedard, K.3
Banfi, B.4
Lardy, B.5
Plastre, O.6
Sienkiewicz, A.7
Forro, L.8
Schlegel, W.9
Krause, K.H.10
-
82
-
-
79954628624
-
NADPH oxidase is involved in post-ischemic brain inflammation
-
Chen, H.; Kim, G.S.; Okami, N.; Narasimhan, P.; Chan, P.H. NADPH oxidase is involved in post-ischemic brain inflammation. Neurobiol. Dis. 2011, 42, 341–348.
-
(2011)
Neurobiol. Dis.
, vol.42
, pp. 341-348
-
-
Chen, H.1
Kim, G.S.2
Okami, N.3
Narasimhan, P.4
Chan, P.H.5
-
83
-
-
82555185635
-
NOX2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke
-
De Silva, T.M.; Brait, V.H.; Drummond, G.R.; Sobey, C.G.; Miller, A.A. NOX2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. PLoS One 2011, 6, e0028393.
-
(2011)
Plos One
, vol.6
-
-
De Silva, T.M.1
Brait, V.H.2
Drummond, G.R.3
Sobey, C.G.4
Miller, A.A.5
-
84
-
-
77956808539
-
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
-
Kleinschnitz, C.; Grund, H.; Wingler, K.; Armitage, M.E.; Jones, E.; Mittal, M.; Barit, D.; Schwarz, T.; Geis, C.; Kraft, P.; et al. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol. 2010, 8, e1000479.
-
(2010)
Plos Biol
, vol.8
-
-
Kleinschnitz, C.1
Grund, H.2
Wingler, K.3
Armitage, M.E.4
Jones, E.5
Mittal, M.6
Barit, D.7
Schwarz, T.8
Geis, C.9
Kraft, P.10
-
85
-
-
84870820048
-
Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia
-
Suzuki, Y.; Hattori, K.; Hamanaka, J.; Murase, T.; Egashira, Y.; Mishiro, K.; Ishiguro, M.; Tsuruma, K.; Hirose, Y.; Tanaka, H.; et al. Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia. Sci. Rep. 2012, 2, doi:10.1038/srep00896.
-
(2012)
Sci. Rep.
, vol.2
-
-
Suzuki, Y.1
Hattori, K.2
Hamanaka, J.3
Murase, T.4
Egashira, Y.5
Mishiro, K.6
Ishiguro, M.7
Tsuruma, K.8
Hirose, Y.9
Tanaka, H.10
-
86
-
-
67849088501
-
Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke
-
Jackman, K.A.; Miller, A.A.; Drummond, G.R.; Sobey, C.G. Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Res. 2009, 1286, 215–220.
-
(2009)
Brain Res
, vol.1286
, pp. 215-220
-
-
Jackman, K.A.1
Miller, A.A.2
Drummond, G.R.3
Sobey, C.G.4
-
87
-
-
77955844394
-
NADPH oxidase NOX1 contributes to ischemic injury in experimental stroke in mice
-
Kahles, T.; Kohnen, A.; Heumueller, S.; Rappert, A.; Bechmann, I.; Liebner, S.; Wittko, I.M.; Neumann-Haefelin, T.; Steinmetz, H.; Schroeder, K.; et al. NADPH oxidase NOX1 contributes to ischemic injury in experimental stroke in mice. Neurobiol. Dis. 2010, 40, 185–192.
-
(2010)
Neurobiol. Dis.
, vol.40
, pp. 185-192
-
-
Kahles, T.1
Kohnen, A.2
Heumueller, S.3
Rappert, A.4
Bechmann, I.5
Liebner, S.6
Wittko, I.M.7
Neumann-Haefelin, T.8
Steinmetz, H.9
Schroeder, K.10
-
88
-
-
84865304732
-
The 1027th target candidate in stroke: Will NADPH oxidase hold up?
-
Radermacher, K.A.; Wingler, K.; Kleikers, P.; Altenhofer, S., Jr.; Hermans, J.; Kleinschnitz, C.; Hhw Schmidt, H. The 1027th target candidate in stroke: Will NADPH oxidase hold up? Exp. Transl. Stroke Med. 2012, 4, 11.
-
(2012)
Exp. Transl. Stroke Med.
, vol.4
, pp. 11
-
-
Radermacher, K.A.1
Wingler, K.2
Kleikers, P.3
Altenhofer, S.4
Hermans, J.5
Kleinschnitz, C.6
Hhw Schmidt, H.7
-
89
-
-
84899750432
-
Evolution of NADPH oxidase inhibitors: Selectivity and mechanisms for target engagement
-
Altenhofer, S.; Radermacher, K.A.; Kleikers, P.; Wingler, K.; Schmidt, H.H. Evolution of NADPH oxidase inhibitors: Selectivity and mechanisms for target engagement. Antioxid. Redox Signal. 2014, in press.
-
(2014)
Antioxid. Redox Signal
-
-
Altenhofer, S.1
Radermacher, K.A.2
Kleikers, P.3
Wingler, K.4
Schmidt, H.H.5
-
90
-
-
55849104900
-
Allopurinol treatment reduces arterial wave reflection in stroke survivors
-
Khan, F.; George, J.; Wong, K.; McSwiggan, S.; Struthers, A.D.; Belch, J.J. Allopurinol treatment reduces arterial wave reflection in stroke survivors. Cardiovasc. Ther. 2008, 26, 247–252.
-
(2008)
Cardiovasc. Ther.
, vol.26
, pp. 247-252
-
-
Khan, F.1
George, J.2
Wong, K.3
McSwiggan, S.4
Struthers, A.D.5
Belch, J.J.6
-
91
-
-
30844439634
-
Glutamate-based therapeutic approaches: Clinical trials with nmda antagonists
-
Muir, K.W. Glutamate-based therapeutic approaches: Clinical trials with nmda antagonists. Curr. Opin. Pharmacol. 2006, 6, 53–60.
-
(2006)
Curr. Opin. Pharmacol.
, vol.6
, pp. 53-60
-
-
Muir, K.W.1
-
92
-
-
70449334334
-
The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial
-
Dawson, J.; Quinn, T.J.; Harrow, C.; Lees, K.R.; Walters, M.R. The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial. Br. J. Clin. Pharmacol. 2009, 68, 662–668.
-
(2009)
Br. J. Clin. Pharmacol.
, vol.68
, pp. 662-668
-
-
Dawson, J.1
Quinn, T.J.2
Harrow, C.3
Lees, K.R.4
Walters, M.R.5
-
93
-
-
0028271830
-
Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia
-
Park, C.K.; Hall, E.D. Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia. Brain Res. 1994, 645, 157–163.
-
(1994)
Brain Res
, vol.645
, pp. 157-163
-
-
Park, C.K.1
Hall, E.D.2
-
94
-
-
0026652877
-
Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats
-
Xue, D.; Slivka, A.; Buchan, A.M. Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats. Stroke 1992, 23, 894–899.
-
(1992)
Stroke
, vol.23
, pp. 894-899
-
-
Xue, D.1
Slivka, A.2
Buchan, A.M.3
-
95
-
-
33846625176
-
Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke
-
Sena, E.; Wheble, P.; Sandercock, P.; Macleod, M. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke 2007, 38, 388–394.
-
(2007)
Stroke
, vol.38
, pp. 388-394
-
-
Sena, E.1
Wheble, P.2
Sandercock, P.3
Macleod, M.4
-
96
-
-
0043204506
-
A randomized trial of tirilazad mesylate in patients with acute stroke (Ranttas). The ranttas investigators
-
RANTTAS. A randomized trial of tirilazad mesylate in patients with acute stroke (ranttas). The ranttas investigators. Stroke 1996, 27, 1453–1458.
-
(1996)
Stroke
, vol.27
, pp. 1453-1458
-
-
-
97
-
-
0000685983
-
Effect of gender and menopausal status on the pharmacokinetics of tirilazad mesylate in healthy subjects
-
Fleishaker, J.C.; Hulst-Pearson, L.K.; Peters, G.R. Effect of gender and menopausal status on the pharmacokinetics of tirilazad mesylate in healthy subjects. Am. J. Ther. 1995, 2, 553–560.
-
(1995)
Am. J. Ther.
, vol.2
, pp. 553-560
-
-
Fleishaker, J.C.1
Hulst-Pearson, L.K.2
Peters, G.R.3
-
98
-
-
0033502692
-
Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat
-
Kuroda, S.; Tsuchidate, R.; Smith, M.L.; Maples, K.R.; Siesjo, B.K. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 1999, 19, 778–787.
-
(1999)
J. Cereb. Blood Flow Metab.
, vol.19
, pp. 778-787
-
-
Kuroda, S.1
Tsuchidate, R.2
Smith, M.L.3
Maples, K.R.4
Siesjo, B.K.5
-
99
-
-
0035800578
-
NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat
-
Zhao, Z.; Cheng, M.; Maples, K.R.; Ma, J.Y.; Buchan, A.M. NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat. Brain Res. 2001, 909, 46–50.
-
(2001)
Brain Res
, vol.909
, pp. 46-50
-
-
Zhao, Z.1
Cheng, M.2
Maples, K.R.3
Ma, J.Y.4
Buchan, A.M.5
-
100
-
-
0036152938
-
Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window
-
Sydserff, S.G.; Borelli, A.R.; Green, A.R.; Cross, A.J. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br. J. Pharmacol. 2002, 135, 103–112.
-
(2002)
Br. J. Pharmacol.
, vol.135
, pp. 103-112
-
-
Sydserff, S.G.1
Borelli, A.R.2
Green, A.R.3
Cross, A.J.4
-
101
-
-
0035154631
-
NXY-059, a free radical—Trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
-
Marshall, J.W.; Duffin, K.J.; Green, A.R.; Ridley, R.M. NXY-059, a free radical—Trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 2001, 32, 190–198.
-
(2001)
Stroke
, vol.32
, pp. 190-198
-
-
Marshall, J.W.1
Duffin, K.J.2
Green, A.R.3
Ridley, R.M.4
-
102
-
-
0042919342
-
Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 h after occlusion
-
Marshall, J.W.; Cummings, R.M.; Bowes, L.J.; Ridley, R.M.; Green, A.R. Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 h after occlusion. Stroke 2003, 34, 2228–2233.
-
(2003)
Stroke
, vol.34
, pp. 2228-2233
-
-
Marshall, J.W.1
Cummings, R.M.2
Bowes, L.J.3
Ridley, R.M.4
Green, A.R.5
-
103
-
-
33845430453
-
Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial
-
Lees, K.R.; Davalos, A.; Davis, S.M.; Diener, H.C.; Grotta, J.; Lyden, P.; Shuaib, A.; Ashwood, T.; Hardemark, H.G.; Wasiewski, W.; et al. Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial. Stroke 2006, 37, 2970–2978.
-
(2006)
Stroke
, vol.37
, pp. 2970-2978
-
-
Lees, K.R.1
Davalos, A.2
Davis, S.M.3
Diener, H.C.4
Grotta, J.5
Lyden, P.6
Shuaib, A.7
Ashwood, T.8
Hardemark, H.G.9
Wasiewski, W.10
-
104
-
-
34547795720
-
NXY-059 for the treatment of acute ischemic stroke
-
Shuaib, A.; Lees, K.R.; Lyden, P.; Grotta, J.; Davalos, A.; Davis, S.M.; Diener, H.C.; Ashwood, T.; Wasiewski, W.W.; Emeribe, U. NXY-059 for the treatment of acute ischemic stroke. N. Engl. J. Med. 2007, 357, 562–571.
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 562-571
-
-
Shuaib, A.1
Lees, K.R.2
Lyden, P.3
Grotta, J.4
Davalos, A.5
Davis, S.M.6
Diener, H.C.7
Ashwood, T.8
Wasiewski, W.W.9
Emeribe, U.10
-
105
-
-
33749001683
-
On the analysis and interpretation of outcome measures in stroke clinical trials: Lessons from the saint i study of NXY-059 for acute ischemic stroke
-
Koziol, J.A.; Feng, A.C. On the analysis and interpretation of outcome measures in stroke clinical trials: Lessons from the saint i study of NXY-059 for acute ischemic stroke. Stroke 2006, 37, 2644–2647.
-
(2006)
Stroke
, vol.37
, pp. 2644-2647
-
-
Koziol, J.A.1
Feng, A.C.2
-
106
-
-
34247643171
-
Clinical impact of NXY-059 demonstrated in the saint I trial: Derivation of number needed to treat for benefit over entire range of functional disability
-
Saver, J.L. Clinical impact of NXY-059 demonstrated in the saint I trial: Derivation of number needed to treat for benefit over entire range of functional disability. Stroke 2007, 38, 1515–1518.
-
(2007)
Stroke
, vol.38
, pp. 1515-1518
-
-
Saver, J.L.1
-
107
-
-
33747189497
-
NXY-059: Brain or vessel protection
-
Fisher, M.; Lees, K.; Papadakis, M.; Buchan, A.M. NXY-059: Brain or vessel protection. Stroke 2006, 37, 2189–2190.
-
(2006)
Stroke
, vol.37
, pp. 2189-2190
-
-
Fisher, M.1
Lees, K.2
Papadakis, M.3
Buchan, A.M.4
-
108
-
-
2542436923
-
Research and development of the free radical scavenger edaravone as a neuroprotectant
-
Watanabe, T.; Tanaka, M.; Watanabe, K.; Takamatsu, Y.; Tobe, A. Research and development of the free radical scavenger edaravone as a neuroprotectant. Yakugaku Zasshi 2004, 124, 99–111.
-
(2004)
Yakugaku Zasshi
, vol.124
, pp. 99-111
-
-
Watanabe, T.1
Tanaka, M.2
Watanabe, K.3
Takamatsu, Y.4
Tobe, A.5
-
109
-
-
77953648503
-
A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy?
-
Lapchak, P.A. A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy? Exp. Opin. Pharmacother. 2010, 11, 1753–1763.
-
(2010)
Exp. Opin. Pharmacother.
, vol.11
, pp. 1753-1763
-
-
Lapchak, P.A.1
-
110
-
-
65649115845
-
Edaravone for the treatment of acute cerebral infarction: Role of endothelium-derived nitric oxide and oxidative stress
-
Higashi, Y. Edaravone for the treatment of acute cerebral infarction: Role of endothelium-derived nitric oxide and oxidative stress. Exp. Opin. Pharmacother. 2009, 10, 323–331.
-
(2009)
Exp. Opin. Pharmacother.
, vol.10
, pp. 323-331
-
-
Higashi, Y.1
-
111
-
-
0028292964
-
Protective effects of MCI-186 on cerebral-ischemia—Possible involvement of free-radical scavenging and antioxidant actions
-
Watanabe, T.; Yuki, S.; Egawa, M.; Nishi, H. Protective effects of MCI-186 on cerebral-ischemia—Possible involvement of free-radical scavenging and antioxidant actions. J. Pharmacol. Exp. Ther. 1994, 268, 1597–1604.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.268
, pp. 1597-1604
-
-
Watanabe, T.1
Yuki, S.2
Egawa, M.3
Nishi, H.4
-
112
-
-
0034730419
-
MCI-186: Further histochemical and biochemical evidence of neuroprotection
-
Wu, T.W.; Zeng, L.H.; Wu, J.; Fung, K.P. MCI-186: Further histochemical and biochemical evidence of neuroprotection. Life Sci. 2000, 67, 2387–2392.
-
(2000)
Life Sci.
, vol.67
, pp. 2387-2392
-
-
Wu, T.W.1
Zeng, L.H.2
Wu, J.3
Fung, K.P.4
-
113
-
-
0036281518
-
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils
-
Jin, Y.J.; Mima, T.; Raicu, V.; Park, K.C.; Shimizu, K. Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. Neurosci. Res. 2002, 43, 75–79.
-
(2002)
Neurosci. Res.
, vol.43
, pp. 75-79
-
-
Jin, Y.J.1
Mima, T.2
Raicu, V.3
Park, K.C.4
Shimizu, K.5
-
114
-
-
84880178138
-
Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model
-
Ikeda, S.; Harada, K.; Ohwatashi, A.; Kamikawa, Y. Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model. Sci. World J. 2013, 2013, 175280.
-
(2013)
Sci. World J.
, vol.2013
, pp. 175280
-
-
Ikeda, S.1
Harada, K.2
Ohwatashi, A.3
Kamikawa, Y.4
-
115
-
-
0037229213
-
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction—Randomized, placebo-controlled, double-blind study at multicenters
-
Otomo, E.; Tohgi, H.; Kogure, K.; Hirai, S.; Takakura, K.; Terashi, A.; Gotoh, F.; Maruyama, S.; Tazaki, Y.; Shinohara, Y. et al. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction—Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovas. Dis. 2003, 15, 222–229.
-
(2003)
Cerebrovas. Dis
, vol.15
, pp. 222-229
-
-
Otomo, E.1
Tohgi, H.2
Kogure, K.3
Hirai, S.4
Takakura, K.5
Terashi, A.6
Gotoh, F.7
Maruyama, S.8
Tazaki, Y.9
Shinohara, Y.10
-
116
-
-
33645681104
-
Efficacy of edaravone in cardioembolic stroke
-
Inatomi, Y.; Takita, T.; Yonehara, T.; Fujioka, S.; Hashimoto, Y.; Hirano, T.; Uchino, M. Efficacy of edaravone in cardioembolic stroke. Int. Med. 2006, 45, 253–257.
-
(2006)
Int. Med.
, vol.45
, pp. 253-257
-
-
Inatomi, Y.1
Takita, T.2
Yonehara, T.3
Fujioka, S.4
Hashimoto, Y.5
Hirano, T.6
Uchino, M.7
-
117
-
-
79953103571
-
Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke
-
Nakase, T.; Yoshioka, S.; Suzuki, A. Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke. BMC Neurol. 2011, 11, 39.
-
(2011)
BMC Neurol
, vol.11
, pp. 39
-
-
Nakase, T.1
Yoshioka, S.2
Suzuki, A.3
-
118
-
-
4644360633
-
Oxidants, antioxidants and the ischemic brain
-
Warner, D.S.; Sheng, H.; Batinic-Haberle, I. Oxidants, antioxidants and the ischemic brain. J. Exp. Biol. 2004, 207, 3221–3231.
-
(2004)
J. Exp. Biol.
, vol.207
, pp. 3221-3231
-
-
Warner, D.S.1
Sheng, H.2
Batinic-Haberle, I.3
-
119
-
-
67349272295
-
Neuroprotective effect of adenoviral catalase gene transfer in cortical neuronal cultures
-
Gaspar, T.; Domoki, F.; Lenti, L.; Institoris, A.; Snipes, J.A.; Bari, F.; Busija, D.W. Neuroprotective effect of adenoviral catalase gene transfer in cortical neuronal cultures. Brain Res. 2009, 1270, 1–9.
-
(2009)
Brain Res
, vol.1270
, pp. 1-9
-
-
Gaspar, T.1
Domoki, F.2
Lenti, L.3
Institoris, A.4
Snipes, J.A.5
Bari, F.6
Busija, D.W.7
-
120
-
-
69249205350
-
Transduced human PEP-1-catalase fusion protein attenuates ischemic neuronal damage
-
Kim, D.W.; Jeong, H.J.; Kang, H.W.; Shin, M.J.; Sohn, E.J.; Kim, M.J.; Ahn, E.H.; An, J.J.; Jang, S.H.; Yoo, K.Y.; et al. Transduced human PEP-1-catalase fusion protein attenuates ischemic neuronal damage. Free Radic. Biol. Med. 2009, 47, 941–952.
-
(2009)
Free Radic. Biol. Med.
, vol.47
, pp. 941-952
-
-
Kim, D.W.1
Jeong, H.J.2
Kang, H.W.3
Shin, M.J.4
Sohn, E.J.5
Kim, M.J.6
Ahn, E.H.7
An, J.J.8
Jang, S.H.9
Yoo, K.Y.10
-
121
-
-
1542327575
-
Catalase over-expression protects striatal neurons from transient focal cerebral ischemia
-
Gu, W.; Zhao, H.; Yenari, M.A.; Sapolsky, R.M.; Steinberg, G.K. Catalase over-expression protects striatal neurons from transient focal cerebral ischemia. Neuroreport 2004, 15, 413–416.
-
(2004)
Neuroreport
, vol.15
, pp. 413-416
-
-
Gu, W.1
Zhao, H.2
Yenari, M.A.3
Sapolsky, R.M.4
Steinberg, G.K.5
-
122
-
-
0031884257
-
Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage
-
Weisbrot-Lefkowitz, M.; Reuhl, K.; Perry, B.; Chan, P.H.; Inouye, M.; Mirochnitchenko, O. Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage. Brain Res. Mol. Brain Res. 1998, 53, 333–338.
-
(1998)
Brain Res. Mol. Brain Res.
, vol.53
, pp. 333-338
-
-
Weisbrot-Lefkowitz, M.1
Reuhl, K.2
Perry, B.3
Chan, P.H.4
Inouye, M.5
Mirochnitchenko, O.6
-
123
-
-
0037203261
-
Glutathione peroxidase inhibits cell death and glial activation following experimental stroke
-
Ishibashi, N.; Prokopenko, O.; Weisbrot-Lefkowitz, M.; Reuhl, K.R.; Mirochnitchenko, O. Glutathione peroxidase inhibits cell death and glial activation following experimental stroke. Brain Res. Mol. Brain Res. 2002, 109, 34–44.
-
(2002)
Brain Res. Mol. Brain Res.
, vol.109
, pp. 34-44
-
-
Ishibashi, N.1
Prokopenko, O.2
Weisbrot-Lefkowitz, M.3
Reuhl, K.R.4
Mirochnitchenko, O.5
-
124
-
-
0034801462
-
Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (GPX-1) knockout mouse brain in response to ischemia/reperfusion injury
-
Crack, P.J.; Taylor, J.M.; Flentjar, N.J.; de Haan, J.; Hertzog, P.; Iannello, R.C.; Kola, I. Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (GPX-1) knockout mouse brain in response to ischemia/reperfusion injury. J. Neurochem. 2001, 78, 1389–1399.
-
(2001)
J. Neurochem.
, vol.78
, pp. 1389-1399
-
-
Crack, P.J.1
Taylor, J.M.2
Flentjar, N.J.3
De Haan, J.4
Hertzog, P.5
Iannello, R.C.6
Kola, I.7
-
125
-
-
0034655765
-
The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice
-
Fujimura, M.; Morita-Fujimura, Y.; Noshita, N.; Sugawara, T.; Kawase, M.; Chan, P.H. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 2000, 20, 2817–2824.
-
(2000)
J. Neurosci.
, vol.20
, pp. 2817-2824
-
-
Fujimura, M.1
Morita-Fujimura, Y.2
Noshita, N.3
Sugawara, T.4
Kawase, M.5
Chan, P.H.6
-
126
-
-
0031304166
-
Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in cuzn-superoxide dismutase gene knockout mutant mice
-
Kondo, T.; Reaume, A.G.; Huang, T.T.; Murakami, K.; Carlson, E.; Chen, S.; Scott, R.W.; Epstein, C.J.; Chan, P.H. Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in cuzn-superoxide dismutase gene knockout mutant mice. Brain Edema X 1997, 70, 62–64.
-
(1997)
Brain Edema X
, vol.70
, pp. 62-64
-
-
Kondo, T.1
Reaume, A.G.2
Huang, T.T.3
Murakami, K.4
Carlson, E.5
Chen, S.6
Scott, R.W.7
Epstein, C.J.8
Chan, P.H.9
-
127
-
-
33750978434
-
Gene therapy using SOD1 protects striatal neurons from experimental stroke
-
Davis, A.S.; Zhao, H.; Sun, G.H.; Sapolsky, R.M.; Steinberg, G.K. Gene therapy using SOD1 protects striatal neurons from experimental stroke. Neurosci. Lett. 2007, 411, 32–36.
-
(2007)
Neurosci. Lett.
, vol.411
, pp. 32-36
-
-
Davis, A.S.1
Zhao, H.2
Sun, G.H.3
Sapolsky, R.M.4
Steinberg, G.K.5
-
128
-
-
0032889085
-
Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia
-
Sheng, H.; Bart, R.D.; Oury, T.D.; Pearlstein, R.D.; Crapo, J.D.; Warner, D.S. Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neuroscience 1999, 88, 185–191.
-
(1999)
Neuroscience
, vol.88
, pp. 185-191
-
-
Sheng, H.1
Bart, R.D.2
Oury, T.D.3
Pearlstein, R.D.4
Crapo, J.D.5
Warner, D.S.6
-
129
-
-
0029177589
-
Oxidative modification of cupro-zinc superoxide dismutase by reactive oxygen species
-
Li, P.F. Oxidative modification of cupro-zinc superoxide dismutase by reactive oxygen species. Sheng Li Ke Xue Jin Zhan 1995, 26, 50–52.
-
(1995)
Sheng Li Ke Xue Jin Zhan
, vol.26
, pp. 50-52
-
-
Li, P.F.1
-
130
-
-
0036304614
-
Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid
-
Kim, G.W.; Chan, P.H. Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid. J. Cereb. Blood Flow Metab. 2002, 22, 798–809.
-
(2002)
J. Cereb. Blood Flow Metab.
, vol.22
, pp. 798-809
-
-
Kim, G.W.1
Chan, P.H.2
-
131
-
-
34248638476
-
A new approach for the investigation of reperfusion-related brain injury
-
Maier, C.M.; Hsieh, L.; Crandall, T.; Narasinnhan, P.; Chan, P.H. A new approach for the investigation of reperfusion-related brain injury. Biochem. Soc. Trans. 2006, 34, 1366–1369.
-
(2006)
Biochem. Soc. Trans.
, vol.34
, pp. 1366-1369
-
-
Maier, C.M.1
Hsieh, L.2
Crandall, T.3
Narasinnhan, P.4
Chan, P.H.5
-
132
-
-
85041566231
-
STAT3 regulates the transcription of the mouse Mn-SOD gene as a neuroprotectant in cerebral ischemic reperfusion
-
Jung, J.E.; Kim, G.S.; Narasimhan, P.; Chan, P.H. STAT3 regulates the transcription of the mouse Mn-SOD gene as a neuroprotectant in cerebral ischemic reperfusion. J. Cereb. Blood Flow Metab. 2009, 29, S565–S566.
-
(2009)
J. Cereb. Blood Flow Metab.
, vol.29
, pp. S565-S566
-
-
Jung, J.E.1
Kim, G.S.2
Narasimhan, P.3
Chan, P.H.4
-
133
-
-
84856209632
-
Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke
-
Jung, J.E.; Kim, G.S.; Chan, P.H. Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. Stroke 2011, 42, 3574–3579.
-
(2011)
Stroke
, vol.42
, pp. 3574-3579
-
-
Jung, J.E.1
Kim, G.S.2
Chan, P.H.3
-
134
-
-
0034884323
-
Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
-
Namura, S.; Nagata, I.; Takami, S.; Masayasu, H.; Kikuchi, H. Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 2001, 32, 1906–1911.
-
(2001)
Stroke
, vol.32
, pp. 1906-1911
-
-
Namura, S.1
Nagata, I.2
Takami, S.3
Masayasu, H.4
Kikuchi, H.5
-
135
-
-
0034821411
-
Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia
-
Imai, H.; Masayasu, H.; Dewar, D.; Graham, D.I.; Macrae, I.M. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke 2001, 32, 2149–2154.
-
(2001)
Stroke
, vol.32
, pp. 2149-2154
-
-
Imai, H.1
Masayasu, H.2
Dewar, D.3
Graham, D.I.4
Macrae, I.M.5
-
136
-
-
0030734080
-
Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion
-
Takasago, T.; Peters, E.E.; Graham, D.I.; Masayasu, H.; Macrae, I.M. Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. Br. J. Pharmacol. 1997, 122, 1251–1256.
-
(1997)
Br. J. Pharmacol.
, vol.122
, pp. 1251-1256
-
-
Takasago, T.1
Peters, E.E.2
Graham, D.I.3
Masayasu, H.4
Macrae, I.M.5
-
137
-
-
0031963836
-
Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. Ebselen study group
-
Yamaguchi, T.; Sano, K.; Takakura, K.; Saito, I.; Shinohara, Y.; Asano, T.; Yasuhara, H. Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. Ebselen study group. Stroke 1998, 29, 12–17.
-
(1998)
Stroke
, vol.29
, pp. 12-17
-
-
Yamaguchi, T.1
Sano, K.2
Takakura, K.3
Saito, I.4
Shinohara, Y.5
Asano, T.6
Yasuhara, H.7
-
138
-
-
34250021071
-
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
-
Ohsawa, I.; Ishikawa, M.; Takahashi, K.; Watanabe, M.; Nishimaki, K.; Yamagata, K.; Katsura, K.-I.; Katayama, Y.; Asoh, S.; Ohta, S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat. Med. 2007, 13, 688–694.
-
(2007)
Nat. Med.
, vol.13
, pp. 688-694
-
-
Ohsawa, I.1
Ishikawa, M.2
Takahashi, K.3
Watanabe, M.4
Nishimaki, K.5
Yamagata, K.6
Katsura, K.-I.7
Katayama, Y.8
Asoh, S.9
Ohta, S.10
-
139
-
-
0036308716
-
Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion
-
Singhal, A.B.; Wang, X.; Sumii, T.; Mori, T.; Lo, E.H. Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J. Cereb. Blood Flow Metab. 2002, 22, 861–868.
-
(2002)
J. Cereb. Blood Flow Metab.
, vol.22
, pp. 861-868
-
-
Singhal, A.B.1
Wang, X.2
Sumii, T.3
Mori, T.4
Lo, E.H.5
-
140
-
-
0037177102
-
Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
-
Singhal, A.B.; Dijkhuizen, R.M.; Rosen, B.R.; Lo, E.H. Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 2002, 58, 945–952.
-
(2002)
Neurology
, vol.58
, pp. 945-952
-
-
Singhal, A.B.1
Dijkhuizen, R.M.2
Rosen, B.R.3
Lo, E.H.4
-
141
-
-
84884154937
-
Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats
-
Esposito, E.; Mandeville, E.T.; Hayakawa, K.; Singhal, A.B.; Lo, E.H. Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp. Neurol. 2013, 249, 33–38.
-
(2013)
Exp. Neurol.
, vol.249
, pp. 33-38
-
-
Esposito, E.1
Mandeville, E.T.2
Hayakawa, K.3
Singhal, A.B.4
Lo, E.H.5
-
142
-
-
16344381726
-
Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia
-
Kim, H.Y.; Singhal, A.B.; Lo, E.H. Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann. Neurol. 2005, 57, 571–575.
-
(2005)
Ann. Neurol.
, vol.57
, pp. 571-575
-
-
Kim, H.Y.1
Singhal, A.B.2
Lo, E.H.3
-
143
-
-
84876822612
-
Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism
-
Geng, X.; Fu, P.; Ji, X.; Peng, C.; Fredrickson, V.; Sy, C.; Meng, R.; Ling, F.; Du, H.; Tan, X. et al. Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism. Stroke 2013, 44, 1418–1425.
-
(2013)
Stroke
, vol.44
, pp. 1418-1425
-
-
Geng, X.1
Fu, P.2
Ji, X.3
Peng, C.4
Fredrickson, V.5
Sy, C.6
Meng, R.7
Ling, F.8
Du, H.9
Tan, X.10
-
144
-
-
84883303463
-
-
Geng, X.; Parmar, S.; Li, X.; Peng, C.; Ji, X.; Chakraborty, T.; Li, W.A.; Du, H.,Tan, X. Ling, F. et al. Reduced apoptosis by combining normobaric oxygenation with ethanol in transient ischemic stroke. Brain Res. 2013, 1531, 17–24.
-
(2013)
Brain Res
, vol.1531
, pp. 17-24
-
-
Geng, X.1
Parmar, S.2
Li, X.3
Peng, C.4
Ji, X.5
Chakraborty, T.6
Li, W.A.7
Dutan, H.8
Ling, X.F.9
-
145
-
-
0028329222
-
The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia
-
Dalkara, T.; Moskowitz, M.A. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol. 1994, 4, 49–57.
-
(1994)
Brain Pathol
, vol.4
, pp. 49-57
-
-
Dalkara, T.1
Moskowitz, M.A.2
-
146
-
-
0027997933
-
Dual role of nitric oxide in focal cerebral ischemia
-
Dalkara, T.; Yoshida, T.; Irikura, K.; Moskowitz, M.A. Dual role of nitric oxide in focal cerebral ischemia. Neuropharmacology 1994, 33, 1447–1452.
-
(1994)
Neuropharmacology
, vol.33
, pp. 1447-1452
-
-
Dalkara, T.1
Yoshida, T.2
Irikura, K.3
Moskowitz, M.A.4
-
147
-
-
4544356494
-
Ischemic stroke: Acidotoxicity is a perpetrator
-
Huang, Y.; McNamara, J.O. Ischemic stroke: Acidotoxicity is a perpetrator. Cell 2004, 118, 665–666.
-
(2004)
Cell
, vol.118
, pp. 665-666
-
-
Huang, Y.1
McNamara, J.O.2
-
148
-
-
84868194682
-
Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model
-
Charriaut-Marlangue, C.; Bonnin, P.; Gharib, A.; Leger, P.-L.; Villapol, S.; Pocard, M.; Gressens, P.; Renolleau, S.; Baud, O. Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. Stroke 2012, 43, 3078–3084.
-
(2012)
Stroke
, vol.43
, pp. 3078-3084
-
-
Charriaut-Marlangue, C.1
Bonnin, P.2
Gharib, A.3
Leger, P.-L.4
Villapol, S.5
Pocard, M.6
Gressens, P.7
Renolleau, S.8
Baud, O.9
-
149
-
-
84857835223
-
Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles
-
Terpolilli, N.A.; Kim, S.-W.; Thal, S.C.; Kataoka, H.; Zeisig, V.; Nitzsche, B.; Klaesner, B.; Zhu, C.; Schwarzmaier, S.; Meissner, L.; et al. Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles. Circ. Res. 2012, 110, 727–738.
-
(2012)
Circ. Res.
, vol.110
, pp. 727-738
-
-
Terpolilli, N.A.1
Kim, S.-W.2
Thal, S.C.3
Kataoka, H.4
Zeisig, V.5
Nitzsche, B.6
Klaesner, B.7
Zhu, C.8
Schwarzmaier, S.9
Meissner, L.10
-
150
-
-
0030426710
-
Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway
-
Lesage, A.S.; Peeters, L.; Leysen, J.E. Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. J. Pharmacol. Exp. Ther. 1996, 279, 759–766.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, pp. 759-766
-
-
Lesage, A.S.1
Peeters, L.2
Leysen, J.E.3
-
151
-
-
0031023404
-
+-channel function as an in vitro model of the ischemic penumbra: Action of lubeluzole and other neuroprotective drugs
-
+-channel function as an in vitro model of the ischemic penumbra: Action of lubeluzole and other neuroprotective drugs. Brain Res. 1997, 745, 210–221.
-
(1997)
Brain Res
, vol.745
, pp. 210-221
-
-
Ashton, D.1
Willems, R.2
Wynants, J.3
Van Reempts, J.4
Marrannes, R.5
Clincke, G.6
-
152
-
-
0031013109
-
Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide
-
Maiese, K.; TenBroeke, M.; Kue, I. Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide. J. Neurochem. 1997, 68, 710–714.
-
(1997)
J. Neurochem.
, vol.68
, pp. 710-714
-
-
Maiese, K.1
Tenbroeke, M.2
Kue, I.3
-
153
-
-
0030426259
-
Lubeluzole protectssensorimotor function and reduces infarct size in a photochemical stroke model in rats
-
De Ryck, M.; Keersmaekers, R.; Duytschaever, H.; Claes, C.; Clincke, G.; Janssen, M.; van Reet, G. Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats. J. Pharmacol. Exp. Ther. 1996, 279, 748–758.
-
(1996)
J. Pharmacol. Exp. Ther
, vol.279
, pp. 748-758
-
-
De Ryck, M.1
Keersmaekers, R.2
Duytschaever, H.3
Claes, C.4
Clincke, G.5
Janssen, M.6
Van Reet, G.7
-
154
-
-
0030175245
-
Treatment of experimental focal ischemia in rats with lubeluzole
-
Aronowski, J.; Strong, R.; Grotta, J.C. Treatment of experimental focal ischemia in rats with lubeluzole. Neuropharmacology 1996, 35, 689–693.
-
(1996)
Neuropharmacology
, vol.35
, pp. 689-693
-
-
Aronowski, J.1
Strong, R.2
Grotta, J.C.3
-
155
-
-
0030069170
-
Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole international study group
-
Diener, H.C.; Hacke, W.; Hennerici, M.; Radberg, J.; Hantson, L.; de Keyser, J. Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole international study group. Stroke 1996, 27, 76–81.
-
(1996)
Stroke
, vol.27
, pp. 76-81
-
-
Diener, H.C.1
Hacke, W.2
Hennerici, M.3
Radberg, J.4
Hantson, L.5
De Keyser, J.6
-
156
-
-
0031438509
-
Lubeluzole treatment of acute ischemic stroke. The US and Canadian lubeluzole ischemic stroke study group
-
Grotta, J. Lubeluzole treatment of acute ischemic stroke. The US and Canadian lubeluzole ischemic stroke study group. Stroke 1997, 28, 2338–2346.
-
(1997)
Stroke
, vol.28
, pp. 2338-2346
-
-
Grotta, J.1
-
157
-
-
0031923952
-
Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke. European and Australian lubeluzole ischaemic stroke study group
-
Diener, H.C. Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke. European and Australian lubeluzole ischaemic stroke study group. Cerebrovasc. Dis 1998, 8, 172–181.
-
(1998)
Cerebrovasc. Dis
, vol.8
, pp. 172-181
-
-
Diener, H.C.1
-
158
-
-
0033766740
-
Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-h inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
-
Diener, H.C.; Cortens, M.; Ford, G.; Grotta, J.; Hacke, W.; Kaste, M.; Koudstaal, P.J.; Wessel, T. Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-h inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. Stroke 2000, 31, 2543–2551.
-
(2000)
Stroke
, vol.31
, pp. 2543-2551
-
-
Diener, H.C.1
Cortens, M.2
Ford, G.3
Grotta, J.4
Hacke, W.5
Kaste, M.6
Koudstaal, P.J.7
Wessel, T.8
-
160
-
-
0015694842
-
Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization
-
Weisiger, R.A.; Fridovich, I. Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J. Biol. Chem. 1973, 248, 4793–4796.
-
(1973)
J. Biol. Chem.
, vol.248
, pp. 4793-4796
-
-
Weisiger, R.A.1
Fridovich, I.2
-
161
-
-
33846818524
-
Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
-
Abramov, A.Y.; Scorziello, A.; Duchen, M.R. Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J. Neurosci. 2007, 27, 1129–1138.
-
(2007)
J. Neurosci.
, vol.27
, pp. 1129-1138
-
-
Abramov, A.Y.1
Scorziello, A.2
Duchen, M.R.3
-
162
-
-
84892368437
-
Antioxidants as therapies: Can we improve on nature?
-
Murphy, M.P. Antioxidants as therapies: Can we improve on nature? Free Radic. Biol. Med. 2014, 66, 20–23.
-
(2014)
Free Radic. Biol. Med.
, vol.66
, pp. 20-23
-
-
Murphy, M.P.1
-
163
-
-
23644441470
-
Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems
-
Siler-Marsiglio, K.I.; Pan, Q.; Paiva, M.; Madorsky, F.; Khurana, N.C.; Heaton, M.B. Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems. Brain Res. 2005, 1052, 202–211.
-
(2005)
Brain Res
, vol.1052
, pp. 202-211
-
-
Siler-Marsiglio, K.I.1
Pan, Q.2
Paiva, M.3
Madorsky, F.4
Khurana, N.C.5
Heaton, M.B.6
-
164
-
-
4444315545
-
Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis
-
Dhanasekaran, A.; Kotamraju, S.; Kalivendi, S.V.; Matsunaga, T.; Shang, T.; Keszler, A.; Joseph, J.; Kalyanaraman, B. Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. J. Biol. Chem. 2004, 279, 37575–37587.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 37575-37587
-
-
Dhanasekaran, A.1
Kotamraju, S.2
Kalivendi, S.V.3
Matsunaga, T.4
Shang, T.5
Keszler, A.6
Joseph, J.7
Kalyanaraman, B.8
-
165
-
-
33847071146
-
Targeting antioxidants to mitochondria by conjugation to lipophilic cations
-
Murphy, M.P.; Smith, R.A. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu. Rev. Pharmacol. Toxicol. 2007, 47, 629–656.
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 629-656
-
-
Murphy, M.P.1
Smith, R.A.2
-
166
-
-
0036237241
-
Prevention of mitochondrial oxidative damage using targeted antioxidants
-
Kelso, G.F.; Porteous, C.M.; Hughes, G.; Ledgerwood, E.C.; Gane, A.M.; Smith, R.A.J.; Murphy, M.P. Prevention of mitochondrial oxidative damage using targeted antioxidants. Increasing Healthy Life Span 2002, 959, 263–274.
-
(2002)
Increasing Healthy Life Span
, vol.959
, pp. 263-274
-
-
Kelso, G.F.1
Porteous, C.M.2
Hughes, G.3
Ledgerwood, E.C.4
Gane, A.M.5
Smith, R.A.J.6
Murphy, M.P.7
-
167
-
-
77955283395
-
Animal and human studies with the mitochondria-targeted antioxidant mitoq
-
Smith, R.A.; Murphy, M.P. Animal and human studies with the mitochondria-targeted antioxidant mitoq. Ann. N. Y. Acad.Sci. 2010, 1201, 96–103.
-
(2010)
Ann. N. Y. Acad.Sci.
, vol.1201
, pp. 96-103
-
-
Smith, R.A.1
Murphy, M.P.2
-
168
-
-
21744450416
-
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
-
Adlam, V.J.; Harrison, J.C.; Porteous, C.M.; James, A.M.; Smith, R.A.; Murphy, M.P.; Sammut, I.A. Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J. 2005, 19, 1088–1095.
-
(2005)
FASEB J
, vol.19
, pp. 1088-1095
-
-
Adlam, V.J.1
Harrison, J.C.2
Porteous, C.M.3
James, A.M.4
Smith, R.A.5
Murphy, M.P.6
Sammut, I.A.7
-
169
-
-
68549112975
-
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy
-
Graham, D.; Huynh, N.N.; Hamilton, C.A.; Beattie, E.; Smith, R.A.; Cocheme, H.M.; Murphy, M.P.; Dominiczak, A.F. Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension 2009, 54, 322–328.
-
(2009)
Hypertension
, vol.54
, pp. 322-328
-
-
Graham, D.1
Huynh, N.N.2
Hamilton, C.A.3
Beattie, E.4
Smith, R.A.5
Cocheme, H.M.6
Murphy, M.P.7
Dominiczak, A.F.8
-
170
-
-
84894067221
-
Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function
-
McLachlan, J.; Beattie, E.; Murphy, M.P.; Koh-Tan, C.H.; Olson, E.; Beattie, W.; Dominiczak, A.F.; Nicklin, S.A.; Graham, D. Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. J. Hypertens. 2014, 32, 555–564.
-
(2014)
J. Hypertens.
, vol.32
, pp. 555-564
-
-
McLachlan, J.1
Beattie, E.2
Murphy, M.P.3
Koh-Tan, C.H.4
Olson, E.5
Beattie, W.6
Dominiczak, A.F.7
Nicklin, S.A.8
Graham, D.9
-
171
-
-
80053602345
-
Protective efficacy of mitochondrial targeted antioxidant mitoq against dichlorvos induced oxidative stress and cell death in rat brain
-
Wani, W.Y.; Gudup, S.; Sunkaria, A.; Bal, A.; Singh, P.P.; Kandimalla, R.J.; Sharma, D.R.; Gill, K.D. Protective efficacy of mitochondrial targeted antioxidant mitoq against dichlorvos induced oxidative stress and cell death in rat brain. Neuropharmacology 2011, 61, 1193–1201.
-
(2011)
Neuropharmacology
, vol.61
, pp. 1193-1201
-
-
Wani, W.Y.1
Gudup, S.2
Sunkaria, A.3
Bal, A.4
Singh, P.P.5
Kandimalla, R.J.6
Sharma, D.R.7
Gill, K.D.8
-
172
-
-
50249123948
-
Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN
-
Hobbs, C.E.; Murphy, M.P.; Smith, R.A.; Oorschot, D.E. Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN. Pediatr. Int. 2008, 50, 481–488.
-
(2008)
Pediatr. Int.
, vol.50
, pp. 481-488
-
-
Hobbs, C.E.1
Murphy, M.P.2
Smith, R.A.3
Oorschot, D.E.4
-
173
-
-
60349113217
-
Ascorbic acid protects the newborn rat brain from hypoxic-ischemia
-
Miura, S.; Ishida-Nakajima, W.; Ishida, A.; Kawamura, M.; Ohmura, A.; Oguma, R.; Sato, Y.; Takahashi, T. Ascorbic acid protects the newborn rat brain from hypoxic-ischemia. Brain Dev. 2009, 31, 307–317.
-
(2009)
Brain Dev
, vol.31
, pp. 307-317
-
-
Miura, S.1
Ishida-Nakajima, W.2
Ishida, A.3
Kawamura, M.4
Ohmura, A.5
Oguma, R.6
Sato, Y.7
Takahashi, T.8
-
174
-
-
80052264760
-
Preclinical evaluation of postischemic dehydroascorbic acid administration in a large-animal stroke model
-
Ducruet, A.F.; Mack, W.J.; Mocco, J.; Hoh, D.J.; Coon, A.L.; D’Ambrosio, A.L.; Winfree, C.J.; Pinsky, D.J.; Connolly, E.S., Jr. Preclinical evaluation of postischemic dehydroascorbic acid administration in a large-animal stroke model. Transl. Stroke Res. 2011, 2, 399–403.
-
(2011)
Transl. Stroke Res.
, vol.2
, pp. 399-403
-
-
Ducruet, A.F.1
Mack, W.J.2
Mocco, J.3
Hoh, D.J.4
Coon, A.L.5
D’Ambrosio, A.L.6
Winfree, C.J.7
Pinsky, D.J.8
Connolly, E.S.9
-
175
-
-
82355191894
-
Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive rats
-
Zhang, X.H.; Lei, H.; Liu, A.J.; Zou, Y.X.; Shen, F.M.; Su, D.F. Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive rats. CNS Neurosci. Ther. 2011, 17, 590–598.
-
(2011)
CNS Neurosci. Ther.
, vol.17
, pp. 590-598
-
-
Zhang, X.H.1
Lei, H.2
Liu, A.J.3
Zou, Y.X.4
Shen, F.M.5
Su, D.F.6
-
176
-
-
0033805259
-
Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a japanese rural community. The shibata study
-
Yokoyama, T.; Date, C.; Kokubo, Y.; Yoshiike, N.; Matsumura, Y.; Tanaka, H. Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a japanese rural community. The shibata study. Stroke 2000, 31, 2287–2294.
-
(2000)
Stroke
, vol.31
, pp. 2287-2294
-
-
Yokoyama, T.1
Date, C.2
Kokubo, Y.3
Yoshiike, N.4
Matsumura, Y.5
Tanaka, H.6
-
177
-
-
38149104641
-
Plasma vitamin C concentrations predict risk of incident stroke over 10 year in 20,649 participants of the european prospective investigation into cancer norfolk prospective population study
-
Myint, P.K.; Luben, R.N.; Welch, A.A.; Bingham, S.A.; Wareham, N.J.; Khaw, K.T. Plasma vitamin C concentrations predict risk of incident stroke over 10 year in 20,649 participants of the european prospective investigation into cancer norfolk prospective population study. Am. J. Clin. Nutr. 2008, 87, 64–69.
-
(2008)
Am. J. Clin. Nutr.
, vol.87
, pp. 64-69
-
-
Myint, P.K.1
Luben, R.N.2
Welch, A.A.3
Bingham, S.A.4
Wareham, N.J.5
Khaw, K.T.6
-
178
-
-
79958251895
-
Dietary intakes of antioxidant vitamins and mortality from cardiovascular disease: The Japan collaborative cohort study (JACC) study
-
Kubota, Y.; Iso, H.; Date, C.; Kikuchi, S.; Watanabe, Y.; Wada, Y.; Inaba, Y.; Tamakoshi, A. Dietary intakes of antioxidant vitamins and mortality from cardiovascular disease: The Japan collaborative cohort study (JACC) study. Stroke 2011, 42, 1665–1672.
-
(2011)
Stroke
, vol.42
, pp. 1665-1672
-
-
Kubota, Y.1
Iso, H.2
Date, C.3
Kikuchi, S.4
Watanabe, Y.5
Wada, Y.6
Inaba, Y.7
Tamakoshi, A.8
-
179
-
-
0037031094
-
MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial
-
Heart Protection Study Collaborative Group. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002, 360, 23–33.
-
(2002)
Lancet
, vol.360
, pp. 23-33
-
-
-
180
-
-
34548040480
-
A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: Results from the women’s antioxidant cardiovascular study
-
Cook, N.R.; Albert, C.M.; Gaziano, J.M.; Zaharris, E.; MacFadyen, J.; Danielson, E.; Buring, J.E.; Manson, J.E. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: Results from the women’s antioxidant cardiovascular study. Arch. Intern. Med. 2007, 167, 1610–1618.
-
(2007)
Arch. Intern. Med.
, vol.167
, pp. 1610-1618
-
-
Cook, N.R.1
Albert, C.M.2
Gaziano, J.M.3
Zaharris, E.4
Macfadyen, J.5
Danielson, E.6
Buring, J.E.7
Manson, J.E.8
-
181
-
-
56149111693
-
Vitamins E and C in the prevention of cardiovascular disease in men: The physicians’ health study II randomized controlled trial
-
Sesso, H.D.; Buring, J.E.; Christen, W.G.; Kurth, T.; Belanger, C.; MacFadyen, J.; Bubes, V.; Manson, J.E.; Glynn, R.J.; Gaziano, J.M. Vitamins E and C in the prevention of cardiovascular disease in men: The physicians’ health study II randomized controlled trial. JAMA 2008, 300, 2123–2133.
-
(2008)
JAMA
, vol.300
, pp. 2123-2133
-
-
Sesso, H.D.1
Buring, J.E.2
Christen, W.G.3
Kurth, T.4
Belanger, C.5
Macfadyen, J.6
Bubes, V.7
Manson, J.E.8
Glynn, R.J.9
Gaziano, J.M.10
-
182
-
-
84881317939
-
Effects of vitamin E on stroke subtypes: Meta-analysis of randomised controlled trials
-
Schurks, M.; Glynn, R.J.; Rist, P.M.; Tzourio, C.; Kurth, T. Effects of vitamin E on stroke subtypes: Meta-analysis of randomised controlled trials. Br. Med. J. 2010, doi:10.1136/bmj.c5702.
-
(2010)
Br. Med. J.
-
-
Schurks, M.1
Glynn, R.J.2
Rist, P.M.3
Tzourio, C.4
Kurth, T.5
-
183
-
-
79955457391
-
The role of vitamin E (Tocopherol) supplementation in the prevention of stroke a meta-analysis of 13 randomised controlled trials
-
Bin, Q.; Hu, X.Y.; Cao, Y.; Gao, F. The role of vitamin E (tocopherol) supplementation in the prevention of stroke a meta-analysis of 13 randomised controlled trials. Thromb. Haemost. 2011, 105, 579–585.
-
(2011)
Thromb. Haemost.
, vol.105
, pp. 579-585
-
-
Bin, Q.1
Hu, X.Y.2
Cao, Y.3
Gao, F.4
-
184
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang, G.L.; Semenza, G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 1995, 270, 1230–1237.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
185
-
-
0036211764
-
Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain
-
Bernaudin, M.; Nedelec, A.S.; Divoux, D.; MacKenzie, E.T.; Petit, E.; Schumann-Bard, P. Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J. Cereb. Blood Flow Metab. 2002, 22, 393–403.
-
(2002)
J. Cereb. Blood Flow Metab.
, vol.22
, pp. 393-403
-
-
Bernaudin, M.1
Nedelec, A.S.2
Divoux, D.3
Mackenzie, E.T.4
Petit, E.5
Schumann-Bard, P.6
-
186
-
-
0034840276
-
Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain
-
Jones, N.M.; Bergeron, M. Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain. J. Cereb. Blood Flow Metab. 2001, 21, 1105–1114.
-
(2001)
J. Cereb. Blood Flow Metab.
, vol.21
, pp. 1105-1114
-
-
Jones, N.M.1
Bergeron, M.2
-
187
-
-
0036249884
-
Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro
-
Prass, K.; Ruscher, K.; Karsch, M.; Isaev, N.; Megow, D.; Priller, J.; Scharff, A.; Dirnagl, U.; Meisel, A. Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J. Cereb. Blood Flow Metab. 2002, 22, 520–525.
-
(2002)
J. Cereb. Blood Flow Metab.
, vol.22
, pp. 520-525
-
-
Prass, K.1
Ruscher, K.2
Karsch, M.3
Isaev, N.4
Megow, D.5
Priller, J.6
Scharff, A.7
Dirnagl, U.8
Meisel, A.9
-
188
-
-
33645450194
-
Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat
-
Freret, T.; Valable, S.; Chazalviel, L.; Saulnier, R.; Mackenzie, E.T.; Petit, E.; Bernaudin, M.; Boulouard, M.; Schumann-Bard, P. Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat. Eur. J. Neurosci. 2006, 23, 1757–1765.
-
(2006)
Eur. J. Neurosci.
, vol.23
, pp. 1757-1765
-
-
Freret, T.1
Valable, S.2
Chazalviel, L.3
Saulnier, R.4
Mackenzie, E.T.5
Petit, E.6
Bernaudin, M.7
Boulouard, M.8
Schumann-Bard, P.9
-
189
-
-
46249131382
-
Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia
-
Wang, X.; Liu, J.; Zhu, H.; Tejima, E.; Tsuji, K.; Murata, Y.; Atochin, D.N.; Huang, P.L.; Zhang, C.; Lo, E.H. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke 2008, 39, 1869–1874.
-
(2008)
Stroke
, vol.39
, pp. 1869-1874
-
-
Wang, X.1
Liu, J.2
Zhu, H.3
Tejima, E.4
Tsuji, K.5
Murata, Y.6
Atochin, D.N.7
Huang, P.L.8
Zhang, C.9
Lo, E.H.10
-
190
-
-
78049458153
-
Neuroglobin protects neurons against oxidative stress in global ischemia
-
Li, R.C.; Guo, S.Z.; Lee, S.K.; Gozal, D. Neuroglobin protects neurons against oxidative stress in global ischemia. J. Cereb. Blood Flow Metab. 2010, 30, 1874–1882.
-
(2010)
J. Cereb. Blood Flow Metab.
, vol.30
, pp. 1874-1882
-
-
Li, R.C.1
Guo, S.Z.2
Lee, S.K.3
Gozal, D.4
-
191
-
-
0037452987
-
Neuroglobin protects the brain from experimental stroke in vivo
-
Sun, Y.; Jin, K.; Peel, A.; Mao, X.O.; Xie, L.; Greenberg, D.A. Neuroglobin protects the brain from experimental stroke in vivo. Proc. Natl. Acad. Sci. USA 2003, 100, 3497–3500.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 3497-3500
-
-
Sun, Y.1
Jin, K.2
Peel, A.3
Mao, X.O.4
Xie, L.5
Greenberg, D.A.6
-
192
-
-
78650950140
-
Tat-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice
-
Cai, B.; Lin, Y.; Xue, X.H.; Fang, L.; Wang, N.; Wu, Z.Y. Tat-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice. Exp. Neurol. 2011, 227, 224–231.
-
(2011)
Exp. Neurol.
, vol.227
, pp. 224-231
-
-
Cai, B.1
Lin, Y.2
Xue, X.H.3
Fang, L.4
Wang, N.5
Wu, Z.Y.6
-
193
-
-
84881119929
-
Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats
-
Ord, E.N.; Shirley, R.; McClure, J.D.; McCabe, C.; Kremer, E.J.; Macrae, I.M.; Work, L.M. Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. J. Cereb. Blood Flow Metab. 2013, 33, 1215–1224.
-
(2013)
J. Cereb. Blood Flow Metab.
, vol.33
, pp. 1215-1224
-
-
Ord, E.N.1
Shirley, R.2
McClure, J.D.3
McCabe, C.4
Kremer, E.J.5
Macrae, I.M.6
Work, L.M.7
-
194
-
-
52649165720
-
Thrombolysis with alteplase 3 to 4.5 h after acute ischemic stroke
-
Hacke, W.; Kaste, M.; Bluhmki, E.; Brozman, M.; Davalos, A.; Guidetti, D.; Larrue, V.; Lees, K.R.; Medeghri, Z.; Machnig, T.; et al. Thrombolysis with alteplase 3 to 4.5 h after acute ischemic stroke. N. Engl. J. Med. 2008, 359, 1317–1329.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1317-1329
-
-
Hacke, W.1
Kaste, M.2
Bluhmki, E.3
Brozman, M.4
Davalos, A.5
Guidetti, D.6
Larrue, V.7
Lees, K.R.8
Medeghri, Z.9
Machnig, T.10
-
195
-
-
11144258914
-
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein c
-
Liu, D.; Cheng, T.; Guo, H.; Fernandez, J.A.; Griffin, J.H.; Song, X.; Zlokovic, B.V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein c. Nat. Med. 2004, 10, 1379–1383.
-
(2004)
Nat. Med.
, vol.10
, pp. 1379-1383
-
-
Liu, D.1
Cheng, T.2
Guo, H.3
Fernandez, J.A.4
Griffin, J.H.5
Song, X.6
Zlokovic, B.V.7
-
196
-
-
33847680458
-
Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia
-
Baker, A.H.; Sica, V.; Work, L.M.; Williams-Ignarro, S.; de Nigris, F.; Lerman, L.O.; Casamassimi, A.; Lanza, A.; Schiano, C.; Rienzo, M.; et al. Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proc. Natl. Acad. Sci. USA 2007, 104, 3597–3602.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3597-3602
-
-
Baker, A.H.1
Sica, V.2
Work, L.M.3
Williams-Ignarro, S.4
De Nigris, F.5
Lerman, L.O.6
Casamassimi, A.7
Lanza, A.8
Schiano, C.9
Rienzo, M.10
-
197
-
-
0034073442
-
Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats
-
Asahi, M.; Asahi, K.; Wang, X.; Lo, E.H. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 2000, 20, 452–457.
-
(2000)
J. Cereb. Blood Flow Metab.
, vol.20
, pp. 452-457
-
-
Asahi, M.1
Asahi, K.2
Wang, X.3
Lo, E.H.4
-
198
-
-
0030271381
-
Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures
-
Barth, A.; Barth, L.; Newell, D.W. Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures. Exp. Neurol. 1996, 141, 330–336.
-
(1996)
Exp. Neurol.
, vol.141
, pp. 330-336
-
-
Barth, A.1
Barth, L.2
Newell, D.W.3
-
199
-
-
84856004974
-
Modifying neurorepair and neuroregenerative factors with TPA and edaravone after transient middle cerebral artery occlusion in rat brain
-
Deguchi, K.; Miyazaki, K.; Tian, F.; Liu, N.; Liu, W.; Kawai, H.; Omote, Y.; Kono, S.; Yunoki, T.; Deguchi, S.; et al. Modifying neurorepair and neuroregenerative factors with TPA and edaravone after transient middle cerebral artery occlusion in rat brain. Brain Res. 2012, 1436, 168–177.
-
(2012)
Brain Res
, vol.1436
, pp. 168-177
-
-
Deguchi, K.1
Miyazaki, K.2
Tian, F.3
Liu, N.4
Liu, W.5
Kawai, H.6
Omote, Y.7
Kono, S.8
Yunoki, T.9
Deguchi, S.10
-
200
-
-
84862531732
-
Prothrombolytic action of normobaric oxygen given alone or in combination with recombinant tissue-plasminogen activator in a rat model of thromboembolic stroke
-
David, H.N.; Haelewyn, B.; Degoulet, M.; Colomb, D.G., Jr.; Risso, J.J.; Abraini, J.H. Prothrombolytic action of normobaric oxygen given alone or in combination with recombinant tissue-plasminogen activator in a rat model of thromboembolic stroke. J. Appl. Physiol. 2012, 112, 2068–2076.
-
(2012)
J. Appl. Physiol.
, vol.112
, pp. 2068-2076
-
-
David, H.N.1
Haelewyn, B.2
Degoulet, M.3
Colomb, D.G.4
Risso, J.J.5
Abraini, J.H.6
-
201
-
-
0033596556
-
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia
-
Schmid-Elsaesser, R.; Hungerhuber, E.; Zausinger, S.; Baethmann, A.; Reulen, H.J. Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia. Brain Res. 1999, 816, 471–479.
-
(1999)
Brain Res
, vol.816
, pp. 471-479
-
-
Schmid-Elsaesser, R.1
Hungerhuber, E.2
Zausinger, S.3
Baethmann, A.4
Reulen, H.J.5
-
202
-
-
84859428889
-
Evaluation of combination therapy in animal models of cerebral ischemia
-
O’Collins, V.E.; Macleod, M.R.; Donnan, G.A.; Howells, D.W. Evaluation of combination therapy in animal models of cerebral ischemia. J. Cereb. Blood Flow Metab. 2012, 32, 585–597.
-
(2012)
J. Cereb. Blood Flow Metab.
, vol.32
, pp. 585-597
-
-
O’Collins, V.E.1
Macleod, M.R.2
Donnan, G.A.3
Howells, D.W.4
-
203
-
-
33751327483
-
Bench to bedside: The quest for quality in experimental stroke research
-
Dirnagl, U. Bench to bedside: The quest for quality in experimental stroke research. J. Cereb. Blood Flow Metab. 2006, 26, 1465–1478.
-
(2006)
J. Cereb. Blood Flow Metab.
, vol.26
, pp. 1465-1478
-
-
Dirnagl, U.1
-
204
-
-
0344065373
-
STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development
-
Stroke Therapy Academic Industry Roundtable (STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1999, 30, 2752–2758.
-
(1999)
Stroke
, vol.30
, pp. 2752-2758
-
-
-
205
-
-
66849097996
-
Update of the stroke therapy academic industry roundtable preclinical recommendations
-
Fisher, M.; Feuerstein, G.; Howells, D.W.; Hurn, P.D.; Kent, T.A.; Savitz, S.I.; Lo, E.H.; Group, F.T.S. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 2009, 40, 2244–2250.
-
(2009)
Stroke
, vol.40
, pp. 2244-2250
-
-
Fisher, M.1
Feuerstein, G.2
Howells, D.W.3
Hurn, P.D.4
Kent, T.A.5
Savitz, S.I.6
Lo, E.H.7
Group, F.T.S.8
-
206
-
-
33644818304
-
1026 Experimental treatments in acute stroke
-
O’Collins, V.E.; Macleod, M.R.; Donnan, G.A.; Horky, L.L.; van der Worp, B.H.; Howells, D.W. 1026 Experimental treatments in acute stroke. Ann. Neurol. 2006, 59, 467–477.
-
(2006)
Ann. Neurol
, vol.59
, pp. 467-477
-
-
O’Collins, V.E.1
Macleod, M.R.2
Donnan, G.A.3
Horky, L.L.4
Van Der Worp, B.H.5
Howells, D.W.6
-
207
-
-
34548475597
-
How can we improve the pre-clinical development of drugs for stroke?
-
Sena, E.S.; van der Worp, H.B.; Howells, D.; Macleod, M. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci. 2007, 30, 433–439.
-
(2007)
Trends Neurosci
, vol.30
, pp. 433-439
-
-
Sena, E.S.1
Van Der Worp, H.B.2
Howells, D.3
Macleod, M.4
-
208
-
-
67650076487
-
Scope of preclinical testing versus quality control within experiments
-
O’Collins, V.E.; Donnan, G.A.; Macleod, M.R.; Howells, D.W. Scope of preclinical testing versus quality control within experiments. Stroke 2009, 40, e497.
-
(2009)
Stroke
, vol.40
-
-
O’Collins, V.E.1
Donnan, G.A.2
Macleod, M.R.3
Howells, D.W.4
-
209
-
-
62449174377
-
Good laboratory practice: Preventing introduction of bias at the bench
-
Macleod, M.R.; Fisher, M.; O’Collins, V.; Sena, E.S.; Dirnagl, U.; Bath, P.M.W.; Buchan, A.; van der Worp, H.B.; Traystman, R.; Minematsu, K.; et al. Good laboratory practice: Preventing introduction of bias at the bench. Stroke 2009, 40, e50–e52.
-
(2009)
Stroke
, vol.40
-
-
Macleod, M.R.1
Fisher, M.2
O’Collins, V.3
Sena, E.S.4
Dirnagl, U.5
Bath, P.M.W.6
Buchan, A.7
Van Der Worp, H.B.8
Traystman, R.9
Minematsu, K.10
-
210
-
-
85041813459
-
Improving bioscience research reporting: The arrive guidelines for reporting animal research
-
Kilkenny, C.; Browne, W.J.; Cuthill, I.C.; Emerson, M.; Altman, D.G. Improving bioscience research reporting: The arrive guidelines for reporting animal research. PLoS Biol. 2010, 8, e1000412.
-
(2010)
Plos Biol
, vol.8
-
-
Kilkenny, C.1
Browne, W.J.2
Cuthill, I.C.3
Emerson, M.4
Altman, D.G.5
-
211
-
-
84880147654
-
A concerted appeal for international cooperation in preclinical stroke research
-
Dirnagl, U.; Hakim, A.; Macleod, M.; Fisher, M.; Howells, D.; Alan, S.M.; Steinberg, G.; Planas, A.; Boltze, J.; Savitz, S.; et al. A concerted appeal for international cooperation in preclinical stroke research. Stroke 2013, 44, 1754–1760.
-
(2013)
Stroke
, vol.44
, pp. 1754-1760
-
-
Dirnagl, U.1
Hakim, A.2
Macleod, M.3
Fisher, M.4
Howells, D.5
Alan, S.M.6
Steinberg, G.7
Planas, A.8
Boltze, J.9
Savitz, S.10
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