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Volumn 3, Issue 3, 2014, Pages 472-501

Oxidative stress and the use of antioxidants in stroke

Author keywords

Anti oxidant; Oxidative stress; Stroke

Indexed keywords


EID: 84969318641     PISSN: None     EISSN: 20763921     Source Type: Journal    
DOI: 10.3390/antiox3030472     Document Type: Review
Times cited : (214)

References (211)
  • 1
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010
    • Lozano, R.; Naghavi, M.; Foreman, K.; Lim, S.; Shibuya, K.; Aboyans, V.; Abraham, J.; Adair, T.; Aggarwal, R.; Ahn, S.Y.; et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010. Lancet 2012, 380, 2095–2128.
    • (2012) Lancet , vol.380 , pp. 2095-2128
    • Lozano, R.1    Naghavi, M.2    Foreman, K.3    Lim, S.4    Shibuya, K.5    Aboyans, V.6    Abraham, J.7    Adair, T.8    Aggarwal, R.9    Ahn, S.Y.10
  • 2
    • 84871099014 scopus 로고    scopus 로고
    • Disability-adjusted life years (Dalys) for 291 diseases and injuries in 21 regions, 1990–2010: A systematic analysis for the global burden of disease study 2010
    • Murray, C.J.L.; Vos, T.; Lozano, R.; Naghavi, M.; Flaxman, A.D.; Michaud, C.; Ezzati, M.; Shibuya, K.; Salomon, J.A.; Abdalla, S.; et al. Disability-adjusted life years (dalys) for 291 diseases and injuries in 21 regions, 1990–2010: A systematic analysis for the global burden of disease study 2010. Lancet 2012, 380, 2197–2223.
    • (2012) Lancet , vol.380 , pp. 2197-2223
    • Murray, C.J.L.1    Vos, T.2    Lozano, R.3    Naghavi, M.4    Flaxman, A.D.5    Michaud, C.6    Ezzati, M.7    Shibuya, K.8    Salomon, J.A.9    Abdalla, S.10
  • 4
    • 84882808439 scopus 로고    scopus 로고
    • Meta-analysis of clinical outcomes of intravenous recombinant tissue plasminogen activator for acute ischemic stroke: Within 3 h versus 3–4.5 h
    • Li, B.-H.; Ding, X.; Yin, Y.-W.; Liu, Y.; Gao, C.-Y.; Zhang, L.-L.; Li, J.-C. Meta-analysis of clinical outcomes of intravenous recombinant tissue plasminogen activator for acute ischemic stroke: Within 3 h versus 3–4.5 h. Curr. Med. Res. Opin. 2013, 29, 1105–1114.
    • (2013) Curr. Med. Res. Opin. , vol.29 , pp. 1105-1114
    • Li, B.-H.1    Ding, X.2    Yin, Y.-W.3    Liu, Y.4    Gao, C.-Y.5    Zhang, L.-L.6    Li, J.-C.7
  • 5
    • 79959981013 scopus 로고    scopus 로고
    • Recombinant tissue-type plasminogen activator use for ischemic stroke in the united states: A doubling of treatment rates over the course of 5 years
    • Adeoye, O.; Hornung, R.; Khatri, P.; Kleindorfer, D. Recombinant tissue-type plasminogen activator use for ischemic stroke in the united states: A doubling of treatment rates over the course of 5 years. Stroke 2011, 42, 1952–1955.
    • (2011) Stroke , vol.42 , pp. 1952-1955
    • Adeoye, O.1    Hornung, R.2    Khatri, P.3    Kleindorfer, D.4
  • 6
    • 79952309760 scopus 로고    scopus 로고
    • Scaling of brain metabolism with a fixed energy budget per neuron: Implications for neuronal activity, plasticity and evolution
    • Herculano-Houzel, S. Scaling of brain metabolism with a fixed energy budget per neuron: Implications for neuronal activity, plasticity and evolution. PLoS One 2011, 6, e17514.
    • (2011) Plos One , vol.6
    • Herculano-Houzel, S.1
  • 7
    • 0021984524 scopus 로고
    • Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells
    • Pauwels, P.J.; Opperdoes, F.R.; Trouet, A. Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells. J. Neurochem. 1985, 44, 143–148.
    • (1985) J. Neurochem. , vol.44 , pp. 143-148
    • Pauwels, P.J.1    Opperdoes, F.R.2    Trouet, A.3
  • 8
    • 65949121134 scopus 로고    scopus 로고
    • Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options
    • Uttara, B.; Singh, A.V.; Zamboni, P.; Mahajan, R.T. Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 2009, 7, 65–74.
    • (2009) Curr. Neuropharmacol. , vol.7 , pp. 65-74
    • Uttara, B.1    Singh, A.V.2    Zamboni, P.3    Mahajan, R.T.4
  • 9
    • 84864330120 scopus 로고    scopus 로고
    • NADPH oxidases as therapeutic targets in ischemic stroke
    • Kahles, T.; Brandes, R.P. NADPH oxidases as therapeutic targets in ischemic stroke. Cell. Mol. Life Sci. 2012, 69, 2345–2363.
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 2345-2363
    • Kahles, T.1    Brandes, R.P.2
  • 10
    • 84872486948 scopus 로고    scopus 로고
    • Molecular mechanisms of ischemia-reperfusion injury in brain: Pivotal role of the mitochondrial membrane potential in reactive oxygen species generation
    • Sanderson, T.H.; Reynolds, C.A.; Kumar, R.; Przyklenk, K.; Huttemann, M. Molecular mechanisms of ischemia-reperfusion injury in brain: Pivotal role of the mitochondrial membrane potential in reactive oxygen species generation. Mol. Neurobiol. 2013, 47, 9–23.
    • (2013) Mol. Neurobiol. , vol.47 , pp. 9-23
    • Sanderson, T.H.1    Reynolds, C.A.2    Kumar, R.3    Przyklenk, K.4    Huttemann, M.5
  • 11
    • 84871607234 scopus 로고    scopus 로고
    • Xanthine oxidase contributes to mitochondrial ros generation in an experimental model of cocaine-induced diastolic dysfunction
    • Vergeade, A.; Mulder, P.; Vendeville, C.; Ventura-Clapier, R.; Thuillez, C.; Monteil, C. Xanthine oxidase contributes to mitochondrial ros generation in an experimental model of cocaine-induced diastolic dysfunction. J. Cardiovasc. Pharmacol. 2012, 60, 538–543.
    • (2012) J. Cardiovasc. Pharmacol. , vol.60 , pp. 538-543
    • Vergeade, A.1    Mulder, P.2    Vendeville, C.3    Ventura-Clapier, R.4    Thuillez, C.5    Monteil, C.6
  • 12
    • 79960543076 scopus 로고    scopus 로고
    • H2O2: A dynamic neuromodulator
    • Rice, M.E. H2O2: A dynamic neuromodulator. Neuroscientist 2011, 17, 389–406.
    • (2011) Neuroscientist , vol.17 , pp. 389-406
    • Rice, M.E.1
  • 13
    • 1542376859 scopus 로고    scopus 로고
    • Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats
    • Liu, S.; Shi, H.; Liu, W.; Furuichi, T.; Timmins, G.S.; Liu, K.J. Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 2004, 24, 343–349.
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 343-349
    • Liu, S.1    Shi, H.2    Liu, W.3    Furuichi, T.4    Timmins, G.S.5    Liu, K.J.6
  • 14
    • 0032880761 scopus 로고    scopus 로고
    • Acidosis potentiates oxidative neuronal death by multiple mechanisms
    • Ying, W.; Han, S.K.; Miller, J.W.; Swanson, R.A. Acidosis potentiates oxidative neuronal death by multiple mechanisms. J. Neurochem. 1999, 73, 1549–1556.
    • (1999) J. Neurochem. , vol.73 , pp. 1549-1556
    • Ying, W.1    Han, S.K.2    Miller, J.W.3    Swanson, R.A.4
  • 15
    • 84860669170 scopus 로고    scopus 로고
    • Comparative impact of voltage-gated calcium channels and nmda receptors on mitochondria-mediated neuronal injury
    • Stanika, R.I.; Villanueva, I.; Kazanina, G.; Andrews, S.B.; Pivovarova, N.B. Comparative impact of voltage-gated calcium channels and nmda receptors on mitochondria-mediated neuronal injury. J. Neurosci. 2012, 32, 6642–6650.
    • (2012) J. Neurosci. , vol.32 , pp. 6642-6650
    • Stanika, R.I.1    Villanueva, I.2    Kazanina, G.3    Andrews, S.B.4    Pivovarova, N.B.5
  • 16
    • 0345735607 scopus 로고    scopus 로고
    • Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke
    • Yamato, M.; Egashira, T.; Utsumi, H. Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke. Free Radic. Biol. Med. 2003, 35, 1619–1631.
    • (2003) Free Radic. Biol. Med. , vol.35 , pp. 1619-1631
    • Yamato, M.1    Egashira, T.2    Utsumi, H.3
  • 17
    • 0031942539 scopus 로고    scopus 로고
    • Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat
    • Peters, O.; Back, T.; Lindauer, U.; Busch, C.; Megow, D.; Dreier, J.; Dirnagl, U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 1998, 18, 196–205.
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 196-205
    • Peters, O.1    Back, T.2    Lindauer, U.3    Busch, C.4    Megow, D.5    Dreier, J.6    Dirnagl, U.7
  • 18
    • 39549102405 scopus 로고    scopus 로고
    • Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
    • Chen, Q.; Moghaddas, S.; Hoppel, C.L.; Lesnefsky, E.J. Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria. Am. J. Physiol. Cell. Physiol. 2008, 294, C460–C466.
    • (2008) Am. J. Physiol. Cell. Physiol. , vol.294 , pp. C460-C466
    • Chen, Q.1    Moghaddas, S.2    Hoppel, C.L.3    Lesnefsky, E.J.4
  • 19
    • 84857508603 scopus 로고    scopus 로고
    • The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice
    • Niatsetskaya, Z.V.; Sosunov, S.A.; Matsiukevich, D.; Utkina-Sosunova, I.V.; Ratner, V.I.; Starkov, A.A.; Ten, V.S. The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice. J. Neurosci. 2012, 32, 3235–3244.
    • (2012) J. Neurosci. , vol.32 , pp. 3235-3244
    • Niatsetskaya, Z.V.1    Sosunov, S.A.2    Matsiukevich, D.3    Utkina-Sosunova, I.V.4    Ratner, V.I.5    Starkov, A.A.6    Ten, V.S.7
  • 21
    • 67649852282 scopus 로고    scopus 로고
    • Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion
    • Chen, H.; Song, Y.S.; Chan, P.H. Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J. Cereb. Blood Flow Metab. 2009, 29, 1262–1272.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 1262-1272
    • Chen, H.1    Song, Y.S.2    Chan, P.H.3
  • 22
    • 0347711117 scopus 로고    scopus 로고
    • NADPH oxidases: Not just for leukocytes anymore!
    • Bokoch, G.M.; Knaus, U.G. NADPH oxidases: Not just for leukocytes anymore! Trends Biochem. Sci. 2003, 28, 502–508.
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 502-508
    • Bokoch, G.M.1    Knaus, U.G.2
  • 23
    • 4544274760 scopus 로고    scopus 로고
    • Nox3 regulation by NOXO1, p47phox, and p67phox
    • Cheng, G.; Ritsick, D.; Lambeth, J.D. Nox3 regulation by NOXO1, p47phox, and p67phox. J. Biol. Chem. 2004, 279, 34250–34255.
    • (2004) J. Biol. Chem. , vol.279 , pp. 34250-34255
    • Cheng, G.1    Ritsick, D.2    Lambeth, J.D.3
  • 24
    • 84874242635 scopus 로고    scopus 로고
    • Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy
    • Matsushima, S.; Kuroda, J.; Ago, T.; Zhai, P.; Park, J.Y.; Xie, L.H.; Tian, B.; Sadoshima, J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circ. Res. 2013, 112, 651–663.
    • (2013) Circ. Res. , vol.112 , pp. 651-663
    • Matsushima, S.1    Kuroda, J.2    Ago, T.3    Zhai, P.4    Park, J.Y.5    Xie, L.H.6    Tian, B.7    Sadoshima, J.8
  • 25
    • 0019440515 scopus 로고
    • Superoxide radicals in feline intestinal ischemia
    • Granger, D.N.; Rutili, G.; McCord, J.M. Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981, 81, 22–29.
    • (1981) Gastroenterology , vol.81 , pp. 22-29
    • Granger, D.N.1    Rutili, G.2    McCord, J.M.3
  • 26
    • 0022502428 scopus 로고
    • Xanthine oxidase: Biochemistry, distribution and physiology
    • Parks, D.A.; Granger, D.N. Xanthine oxidase: Biochemistry, distribution and physiology. Acta Physiol. Scand. Suppl. 1986, 548, 87–99.
    • (1986) Acta Physiol. Scand. Suppl. , vol.548 , pp. 87-99
    • Parks, D.A.1    Granger, D.N.2
  • 27
    • 18844412788 scopus 로고    scopus 로고
    • Reactive oxygen species and the modulation of stroke
    • Crack, P.J.; Taylor, J.M. Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med. 2005, 38, 1433–1444.
    • (2005) Free Radic. Biol. Med. , vol.38 , pp. 1433-1444
    • Crack, P.J.1    Taylor, J.M.2
  • 28
    • 2542551340 scopus 로고    scopus 로고
    • Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia
    • Gursoy-Ozdemir, Y.; Can, A.; Dalkara, T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 2004, 35, 1449–1453.
    • (2004) Stroke , vol.35 , pp. 1449-1453
    • Gursoy-Ozdemir, Y.1    Can, A.2    Dalkara, T.3
  • 31
    • 67349099098 scopus 로고    scopus 로고
    • Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats
    • Matsuda, S.; Umeda, M.; Uchida, H.; Kato, H.; Araki, T. Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats. J. Neural Transm. 2009, 116, 395–404.
    • (2009) J. Neural Transm. , vol.116 , pp. 395-404
    • Matsuda, S.1    Umeda, M.2    Uchida, H.3    Kato, H.4    Araki, T.5
  • 33
    • 0030943111 scopus 로고    scopus 로고
    • Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death
    • Chen, J.; Jin, K.; Chen, M.; Pei, W.; Kawaguchi, K.; Greenberg, D.A.; Simon, R.P. Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death. J. Neurochem. 1997, 69, 232–245.
    • (1997) J. Neurochem. , vol.69 , pp. 232-245
    • Chen, J.1    Jin, K.2    Chen, M.3    Pei, W.4    Kawaguchi, K.5    Greenberg, D.A.6    Simon, R.P.7
  • 34
    • 0034068520 scopus 로고    scopus 로고
    • Activation of poly(Adp-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia
    • Nagayama, T.; Simon, R.P.; Chen, D.; Henshall, D.C.; Pei, W.; Stetler, R.A.; Chen, J. Activation of poly(adp-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia. J. Neurochem. 2000, 74, 1636–1645.
    • (2000) J. Neurochem. , vol.74 , pp. 1636-1645
    • Nagayama, T.1    Simon, R.P.2    Chen, D.3    Henshall, D.C.4    Pei, W.5    Stetler, R.A.6    Chen, J.7
  • 35
    • 0032909814 scopus 로고    scopus 로고
    • Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: Implication of the failure of DNA repair in neuronal apoptosis
    • Kawase, M.; Fujimura, M.; Morita-Fujimura, Y.; Chan, P.H. Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: Implication of the failure of DNA repair in neuronal apoptosis. Stroke 1999, 30, 441–449.
    • (1999) Stroke , vol.30 , pp. 441-449
    • Kawase, M.1    Fujimura, M.2    Morita-Fujimura, Y.3    Chan, P.H.4
  • 36
    • 0036703753 scopus 로고    scopus 로고
    • A bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death
    • Kirkland, R.A.; Windelborn, J.A.; Kasprzak, J.M.; Franklin, J.L. A bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death. J. Neurosci. 2002, 22, 6480–6490.
    • (2002) J. Neurosci. , vol.22 , pp. 6480-6490
    • Kirkland, R.A.1    Windelborn, J.A.2    Kasprzak, J.M.3    Franklin, J.L.4
  • 37
    • 0036883891 scopus 로고    scopus 로고
    • Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release
    • Sugawara, T.; Lewen, A.; Gasche, Y.; Yu, F.; Chan, P.H. Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release. FASEB J. 2002, 16, 1997–1999.
    • (2002) FASEB J , vol.16 , pp. 1997-1999
    • Sugawara, T.1    Lewen, A.2    Gasche, Y.3    Yu, F.4    Chan, P.H.5
  • 38
    • 0025831476 scopus 로고
    • Calcium-activated neutral protease (Calpain) system: Structure, function, and regulation
    • Croall, D.E.; DeMartino, G.N. Calcium-activated neutral protease (calpain) system: Structure, function, and regulation. Physiol. Rev. 1991, 71, 813–847.
    • (1991) Physiol. Rev. , vol.71 , pp. 813-847
    • Croall, D.E.1    Demartino, G.N.2
  • 39
    • 0035853767 scopus 로고    scopus 로고
    • Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling
    • Scorrano, L.; Penzo, D.; Petronilli, V.; Pagano, F.; Bernardi, P. Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling. J. Biol. Chem. 2001, 276, 12035–12040.
    • (2001) J. Biol. Chem , vol.276 , pp. 12035-12040
    • Scorrano, L.1    Penzo, D.2    Petronilli, V.3    Pagano, F.4    Bernardi, P.5
  • 40
    • 0031888955 scopus 로고    scopus 로고
    • A caspase-activated dnase that degrades DNA during apoptosis, and its inhibitor icad
    • Enari, M.; Sakahira, H.; Yokoyama, H.; Okawa, K.; Iwamatsu, A.; Nagata, S. A caspase-activated dnase that degrades DNA during apoptosis, and its inhibitor icad. Nature 1998, 391, 43–50.
    • (1998) Nature , vol.391 , pp. 43-50
    • Enari, M.1    Sakahira, H.2    Yokoyama, H.3    Okawa, K.4    Iwamatsu, A.5    Nagata, S.6
  • 41
    • 0040298568 scopus 로고    scopus 로고
    • Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
    • Jänicke, R.U.; Sprengart, M.L.; Wati, M.R.; Porter, A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 1998, 273, 9357–9360.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9357-9360
    • Jänicke, R.U.1    Sprengart, M.L.2    Wati, M.R.3    Porter, A.G.4
  • 42
    • 40049091482 scopus 로고    scopus 로고
    • The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme
    • Hanus, J.; Kalinowska-Herok, M.; Widlak, P. The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme. Apoptosis 2008, 13, 377–382.
    • (2008) Apoptosis , vol.13 , pp. 377-382
    • Hanus, J.1    Kalinowska-Herok, M.2    Widlak, P.3
  • 43
    • 0034677931 scopus 로고    scopus 로고
    • Cleavage preferences of the apoptotic endonuclease DFF40 (Caspase-activated dnase or nuclease) on naked DNA and chromatin substrates
    • Widlak, P.; Li, P.; Wang, X.; Garrard, W.T. Cleavage preferences of the apoptotic endonuclease DFF40 (caspase-activated dnase or nuclease) on naked DNA and chromatin substrates. J. Biol. Chem. 2000, 275, 8226–8232.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8226-8232
    • Widlak, P.1    Li, P.2    Wang, X.3    Garrard, W.T.4
  • 45
    • 77954624383 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • Pautz, A.; Art, J.; Hahn, S.; Nowag, S.; Voss, C.; Kleinert, H. Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide 2010, 23, 75–93.
    • (2010) Nitric Oxide , vol.23 , pp. 75-93
    • Pautz, A.1    Art, J.2    Hahn, S.3    Nowag, S.4    Voss, C.5    Kleinert, H.6
  • 46
    • 77955850553 scopus 로고    scopus 로고
    • Ischemic preconditioning mediates cyclooxygenase-2 expression via nuclear factor-kappa B activation in mixed cortical neuronal cultures
    • Kim, E.J.; Raval, A.P.; Hirsch, N.; Perez-Pinzon, M.A. Ischemic preconditioning mediates cyclooxygenase-2 expression via nuclear factor-kappa B activation in mixed cortical neuronal cultures. Transl. Stroke Res. 2010, 1, 40–47.
    • (2010) Transl. Stroke Res. , vol.1 , pp. 40-47
    • Kim, E.J.1    Raval, A.P.2    Hirsch, N.3    Perez-Pinzon, M.A.4
  • 47
    • 78649716241 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces matrix metalloproteinase-9 and cell migration in astrocytes: Roles of ros-dependent ERK- and JNK-NF-kappaB pathways
    • Hsieh, H.L.; Wang, H.H.; Wu, W.B.; Chu, P.J.; Yang, C.M. Transforming growth factor-beta1 induces matrix metalloproteinase-9 and cell migration in astrocytes: Roles of ros-dependent ERK- and JNK-NF-kappaB pathways. J. Neuroinflamm. 2010, 7, 88.
    • (2010) J. Neuroinflamm. , vol.7 , pp. 88
    • Hsieh, H.L.1    Wang, H.H.2    Wu, W.B.3    Chu, P.J.4    Yang, C.M.5
  • 48
    • 84877574716 scopus 로고    scopus 로고
    • Prostaglandin e(2)-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd
    • Park, T.Y.; Baik, E.J.; Lee, S.H. Prostaglandin e(2)-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd.3 brain endothelial cells. Br. J. Pharmacol. 2013, 169, 604–618.
    • (2013) Br. J. Pharmacol. , vol.169 , Issue.3 , pp. 604-618
    • Park, T.Y.1    Baik, E.J.2    Lee, S.H.3
  • 49
    • 0035968287 scopus 로고    scopus 로고
    • Novel role for JNK as a stress-activated Bcl2 kinase
    • Deng, X.; Xiao, L.; Lang, W.; Gao, F.; Ruvolo, P.; May, W.S., Jr. Novel role for JNK as a stress-activated Bcl2 kinase. J. Biol. Chem. 2001, 276, 23681–23688.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23681-23688
    • Deng, X.1    Xiao, L.2    Lang, W.3    Gao, F.4    Ruvolo, P.5    May, W.S.6
  • 50
    • 0035735754 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy
    • Fan, M.; Chambers, T.C. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist. Updat 2001, 4, 253–267.
    • (2001) Drug Resist. Updat , vol.4 , pp. 253-267
    • Fan, M.1    Chambers, T.C.2
  • 51
    • 59049090581 scopus 로고    scopus 로고
    • Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution
    • Soberanes, S.; Urich, D.; Baker, C.M.; Burgess, Z.; Chiarella, S.E.; Bell, E.L.; Ghio, A.J.; de Vizcaya-Ruiz, A.; Liu, J.; Ridge, K.M. et al. Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J. Biol. Chem. 2009, 284, 2176–2186.
    • (2009) J. Biol. Chem , vol.284 , pp. 2176-2186
    • Soberanes, S.1    Urich, D.2    Baker, C.M.3    Burgess, Z.4    Chiarella, S.E.5    Bell, E.L.6    Ghio, A.J.7    De Vizcaya-Ruiz, A.8    Liu, J.9    Ridge, K.M.10
  • 54
    • 0033862478 scopus 로고    scopus 로고
    • Serial mri after transient focal cerebral ischemia in rats: Dynamics of tissue injury, blood-brain barrier damage, and edema formation
    • Neumann-Haefelin, T.; Kastrup, A.; de Crespigny, A.; Yenari, M.A.; Ringer, T.; Sun, G.H.; Moseley, M.E. Serial mri after transient focal cerebral ischemia in rats: Dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke 2000, 31, 1965–1973.
    • Stroke , vol.2000 , pp. 31
    • Neumann-Haefelin, T.1    Kastrup, A.2    De Crespigny, A.3    Yenari, M.A.4    Ringer, T.5    Sun, G.H.6    Moseley, M.E.7
  • 55
    • 41149090849 scopus 로고    scopus 로고
    • Mmp-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke
    • Rosell, A.; Cuadrado, E.; Ortega-Aznar, A.; Hernández-Guillamon, M.; Lo, E.H.; Montaner, J. Mmp-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke 2008, 39, 1121–1126.
    • (2008) Stroke , vol.39 , pp. 1121-1126
    • Rosell, A.1    Cuadrado, E.2    Ortega-Aznar, A.3    Hernández-Guillamon, M.4    Lo, E.H.5    Montaner, J.6
  • 57
    • 0036084919 scopus 로고    scopus 로고
    • Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation
    • Mark, K.S.; Davis, T.P. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 2002, 282, H1485–H1494.
    • (2002) Am. J. Physiol. Heart Circ. Physiol , vol.282 , pp. H1485-H1494
    • Mark, K.S.1    Davis, T.P.2
  • 59
    • 9644259030 scopus 로고    scopus 로고
    • Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide
    • Yamagata, K.; Tagami, M.; Takenaga, F.; Yamori, Y.; Itoh, S. Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide. Neurobiol. Dis. 2004, 17, 491–499.
    • (2004) Neurobiol. Dis. , vol.17 , pp. 491-499
    • Yamagata, K.1    Tagami, M.2    Takenaga, F.3    Yamori, Y.4    Itoh, S.5
  • 60
    • 0028093281 scopus 로고
    • Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding
    • Pokutta, S.; Herrenknecht, K.; Kemler, R.; Engel, J. Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur. J. Biochem. 1994, 223, 1019–1026.
    • (1994) Eur. J. Biochem. , vol.223 , pp. 1019-1026
    • Pokutta, S.1    Herrenknecht, K.2    Kemler, R.3    Engel, J.4
  • 61
    • 2542501568 scopus 로고    scopus 로고
    • Transcellular transport as a mechanism of blood-brain barrier disruption during stroke
    • Cipolla, M.J.; Crete, R.; Vitullo, L.; Rix, R.D. Transcellular transport as a mechanism of blood-brain barrier disruption during stroke. Front. Biosci. 2004, 9, 777–785.
    • (2004) Front. Biosci. , vol.9 , pp. 777-785
    • Cipolla, M.J.1    Crete, R.2    Vitullo, L.3    Rix, R.D.4
  • 62
    • 23244447749 scopus 로고    scopus 로고
    • Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier
    • Xu, H.; Dawson, R.; Crane, I.J.; Liversidge, J. Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier. Investig. Ophthalmol. Vis. Sci. 2005, 46, 2487–2494.
    • (2005) Investig. Ophthalmol. Vis. Sci. , vol.46 , pp. 2487-2494
    • Xu, H.1    Dawson, R.2    Crane, I.J.3    Liversidge, J.4
  • 63
    • 33846380363 scopus 로고    scopus 로고
    • Peri)vascular production and action of pro-inflammatory cytokines in brain pathology
    • Konsman, J.P.; Drukarch, B.; van Dam, A.M. (Peri)vascular production and action of pro-inflammatory cytokines in brain pathology. Clin. Sci. 2007, 112, 1–25.
    • (2007) Clin. Sci , vol.112 , pp. 1-25
    • Konsman, J.P.1    Drukarch, B.2    Van Dam, A.M.3
  • 64
    • 77954313737 scopus 로고    scopus 로고
    • Complement activation on platelets: Implications for vascular inflammation and thrombosis
    • Peerschke, E.I.; Yin, W.; Ghebrehiwet, B. Complement activation on platelets: Implications for vascular inflammation and thrombosis. Mol. Immunol. 2010, 47, 2170–2175.
    • (2010) Mol. Immunol. , vol.47 , pp. 2170-2175
    • Peerschke, E.I.1    Yin, W.2    Ghebrehiwet, B.3
  • 65
    • 0030030124 scopus 로고    scopus 로고
    • Hypoxia-induced exocytosis of endothelial cell weibel-palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation
    • Pinsky, D.J.; Naka, Y.; Liao, H.; Oz, M.C.; Wagner, D.D.; Mayadas, T.N.; Johnson, R.C.; Hynes, R.O.; Heath, M.; Lawson, C.A.; et al. Hypoxia-induced exocytosis of endothelial cell weibel-palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J. Clin. Investig. 1996, 97, 493–500.
    • (1996) J. Clin. Investig. , vol.97 , pp. 493-500
    • Pinsky, D.J.1    Naka, Y.2    Liao, H.3    Oz, M.C.4    Wagner, D.D.5    Mayadas, T.N.6    Johnson, R.C.7    Hynes, R.O.8    Heath, M.9    Lawson, C.A.10
  • 66
    • 77954482190 scopus 로고    scopus 로고
    • Leukocyte recruitment and ischemic brain injury
    • Yilmaz, G.; Granger, D.N. Leukocyte recruitment and ischemic brain injury. Neuromol. Med. 2010, 12, 193–204.
    • (2010) Neuromol. Med. , vol.12 , pp. 193-204
    • Yilmaz, G.1    Granger, D.N.2
  • 68
    • 0025947863 scopus 로고
    • Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons
    • Del Zoppo, G.J.; Schmid-Schonbein, G.W.; Mori, E.; Copeland, B.R.; Chang, C.M. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 1991, 22, 1276–1283.
    • (1991) Stroke , vol.22 , pp. 1276-1283
    • Del Zoppo, G.J.1    Schmid-Schonbein, G.W.2    Mori, E.3    Copeland, B.R.4    Chang, C.M.5
  • 69
    • 24144447012 scopus 로고    scopus 로고
    • ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia
    • Melani, A.; Turchi, D.; Vannucchi, M.G.; Cipriani, S.; Gianfriddo, M.; Pedata, F. ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem. Int. 2005, 47, 442–448.
    • (2005) Neurochem. Int. , vol.47 , pp. 442-448
    • Melani, A.1    Turchi, D.2    Vannucchi, M.G.3    Cipriani, S.4    Gianfriddo, M.5    Pedata, F.6
  • 70
    • 3242673859 scopus 로고    scopus 로고
    • Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts
    • Korcok, J.; Raimundo, L.N.; Ke, H.Z.; Sims, S.M.; Dixon, S.J. Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts. J. Bone Miner. Res. 2004, 19, 642–651.
    • (2004) J. Bone Miner. Res. , vol.19 , pp. 642-651
    • Korcok, J.1    Raimundo, L.N.2    Ke, H.Z.3    Sims, S.M.4    Dixon, S.J.5
  • 71
    • 34547680192 scopus 로고    scopus 로고
    • CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4
    • Lyons, A.; Downer, E.J.; Crotty, S.; Nolan, Y.M.; Mills, K.H.; Lynch, M.A. CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4. J. Neurosci. 2007, 27, 8309–8313.
    • (2007) J. Neurosci. , vol.27 , pp. 8309-8313
    • Lyons, A.1    Downer, E.J.2    Crotty, S.3    Nolan, Y.M.4    Mills, K.H.5    Lynch, M.A.6
  • 72
    • 52549109505 scopus 로고    scopus 로고
    • Role of CX3CR1 (Fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse
    • Denes, A.; Ferenczi, S.; Halasz, J.; Kornyei, Z.; Kovacs, K.J. Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse. J. Cereb. Blood Flow Metab. 2008, 28, 1707–1721.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 1707-1721
    • Denes, A.1    Ferenczi, S.2    Halasz, J.3    Kornyei, Z.4    Kovacs, K.J.5
  • 73
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen, G.Y.; Nunez, G. Sterile inflammation: Sensing and reacting to damage. Nat. Rev. Immunol. 2010, 10, 826–837.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 74
    • 59349116736 scopus 로고    scopus 로고
    • Toll-like receptor signaling in endogenous neuroprotection and stroke
    • Marsh, B.J.; Williams-Karnesky, R.L.; Stenzel-Poore, M.P. Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience 2009, 158, 1007–1020.
    • (2009) Neuroscience , vol.158 , pp. 1007-1020
    • Marsh, B.J.1    Williams-Karnesky, R.L.2    Stenzel-Poore, M.P.3
  • 76
  • 77
    • 34547858520 scopus 로고    scopus 로고
    • Apocynin attenuates cerebral infarction after transient focal ischaemia in rats
    • Tang, L.L.; Ye, K.; Yang, X.F.; Zheng, J.S. Apocynin attenuates cerebral infarction after transient focal ischaemia in rats. J. Int. Med. Res. 2007, 35, 517–522.
    • (2007) J. Int. Med. Res. , vol.35 , pp. 517-522
    • Tang, L.L.1    Ye, K.2    Yang, X.F.3    Zheng, J.S.4
  • 78
    • 79151470304 scopus 로고    scopus 로고
    • Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats
    • Genovese, T.; Mazzon, E.; Paterniti, I.; Esposito, E.; Bramanti, P.; Cuzzocrea, S. Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats. Brain Res. 2011, 1372, 92–102.
    • (2011) Brain Res , vol.1372 , pp. 92-102
    • Genovese, T.1    Mazzon, E.2    Paterniti, I.3    Esposito, E.4    Bramanti, P.5    Cuzzocrea, S.6
  • 79
    • 49349093647 scopus 로고    scopus 로고
    • Early increase of NOX4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats
    • McCann, S.K.; Dusting, G.J.; Roulston, C.L. Early increase of NOX4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats. J. Neurosci. Res. 2008, 86, 2524–2534.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 2524-2534
    • McCann, S.K.1    Dusting, G.J.2    Roulston, C.L.3
  • 82
    • 79954628624 scopus 로고    scopus 로고
    • NADPH oxidase is involved in post-ischemic brain inflammation
    • Chen, H.; Kim, G.S.; Okami, N.; Narasimhan, P.; Chan, P.H. NADPH oxidase is involved in post-ischemic brain inflammation. Neurobiol. Dis. 2011, 42, 341–348.
    • (2011) Neurobiol. Dis. , vol.42 , pp. 341-348
    • Chen, H.1    Kim, G.S.2    Okami, N.3    Narasimhan, P.4    Chan, P.H.5
  • 83
    • 82555185635 scopus 로고    scopus 로고
    • NOX2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke
    • De Silva, T.M.; Brait, V.H.; Drummond, G.R.; Sobey, C.G.; Miller, A.A. NOX2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. PLoS One 2011, 6, e0028393.
    • (2011) Plos One , vol.6
    • De Silva, T.M.1    Brait, V.H.2    Drummond, G.R.3    Sobey, C.G.4    Miller, A.A.5
  • 86
    • 67849088501 scopus 로고    scopus 로고
    • Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke
    • Jackman, K.A.; Miller, A.A.; Drummond, G.R.; Sobey, C.G. Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Res. 2009, 1286, 215–220.
    • (2009) Brain Res , vol.1286 , pp. 215-220
    • Jackman, K.A.1    Miller, A.A.2    Drummond, G.R.3    Sobey, C.G.4
  • 91
    • 30844439634 scopus 로고    scopus 로고
    • Glutamate-based therapeutic approaches: Clinical trials with nmda antagonists
    • Muir, K.W. Glutamate-based therapeutic approaches: Clinical trials with nmda antagonists. Curr. Opin. Pharmacol. 2006, 6, 53–60.
    • (2006) Curr. Opin. Pharmacol. , vol.6 , pp. 53-60
    • Muir, K.W.1
  • 92
    • 70449334334 scopus 로고    scopus 로고
    • The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial
    • Dawson, J.; Quinn, T.J.; Harrow, C.; Lees, K.R.; Walters, M.R. The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial. Br. J. Clin. Pharmacol. 2009, 68, 662–668.
    • (2009) Br. J. Clin. Pharmacol. , vol.68 , pp. 662-668
    • Dawson, J.1    Quinn, T.J.2    Harrow, C.3    Lees, K.R.4    Walters, M.R.5
  • 93
    • 0028271830 scopus 로고
    • Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia
    • Park, C.K.; Hall, E.D. Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia. Brain Res. 1994, 645, 157–163.
    • (1994) Brain Res , vol.645 , pp. 157-163
    • Park, C.K.1    Hall, E.D.2
  • 94
    • 0026652877 scopus 로고
    • Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats
    • Xue, D.; Slivka, A.; Buchan, A.M. Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats. Stroke 1992, 23, 894–899.
    • (1992) Stroke , vol.23 , pp. 894-899
    • Xue, D.1    Slivka, A.2    Buchan, A.M.3
  • 95
    • 33846625176 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke
    • Sena, E.; Wheble, P.; Sandercock, P.; Macleod, M. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke 2007, 38, 388–394.
    • (2007) Stroke , vol.38 , pp. 388-394
    • Sena, E.1    Wheble, P.2    Sandercock, P.3    Macleod, M.4
  • 96
    • 0043204506 scopus 로고    scopus 로고
    • A randomized trial of tirilazad mesylate in patients with acute stroke (Ranttas). The ranttas investigators
    • RANTTAS. A randomized trial of tirilazad mesylate in patients with acute stroke (ranttas). The ranttas investigators. Stroke 1996, 27, 1453–1458.
    • (1996) Stroke , vol.27 , pp. 1453-1458
  • 97
    • 0000685983 scopus 로고
    • Effect of gender and menopausal status on the pharmacokinetics of tirilazad mesylate in healthy subjects
    • Fleishaker, J.C.; Hulst-Pearson, L.K.; Peters, G.R. Effect of gender and menopausal status on the pharmacokinetics of tirilazad mesylate in healthy subjects. Am. J. Ther. 1995, 2, 553–560.
    • (1995) Am. J. Ther. , vol.2 , pp. 553-560
    • Fleishaker, J.C.1    Hulst-Pearson, L.K.2    Peters, G.R.3
  • 98
    • 0033502692 scopus 로고    scopus 로고
    • Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat
    • Kuroda, S.; Tsuchidate, R.; Smith, M.L.; Maples, K.R.; Siesjo, B.K. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 1999, 19, 778–787.
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 778-787
    • Kuroda, S.1    Tsuchidate, R.2    Smith, M.L.3    Maples, K.R.4    Siesjo, B.K.5
  • 99
    • 0035800578 scopus 로고    scopus 로고
    • NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat
    • Zhao, Z.; Cheng, M.; Maples, K.R.; Ma, J.Y.; Buchan, A.M. NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat. Brain Res. 2001, 909, 46–50.
    • (2001) Brain Res , vol.909 , pp. 46-50
    • Zhao, Z.1    Cheng, M.2    Maples, K.R.3    Ma, J.Y.4    Buchan, A.M.5
  • 100
    • 0036152938 scopus 로고    scopus 로고
    • Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window
    • Sydserff, S.G.; Borelli, A.R.; Green, A.R.; Cross, A.J. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br. J. Pharmacol. 2002, 135, 103–112.
    • (2002) Br. J. Pharmacol. , vol.135 , pp. 103-112
    • Sydserff, S.G.1    Borelli, A.R.2    Green, A.R.3    Cross, A.J.4
  • 101
    • 0035154631 scopus 로고    scopus 로고
    • NXY-059, a free radical—Trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
    • Marshall, J.W.; Duffin, K.J.; Green, A.R.; Ridley, R.M. NXY-059, a free radical—Trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 2001, 32, 190–198.
    • (2001) Stroke , vol.32 , pp. 190-198
    • Marshall, J.W.1    Duffin, K.J.2    Green, A.R.3    Ridley, R.M.4
  • 102
    • 0042919342 scopus 로고    scopus 로고
    • Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 h after occlusion
    • Marshall, J.W.; Cummings, R.M.; Bowes, L.J.; Ridley, R.M.; Green, A.R. Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 h after occlusion. Stroke 2003, 34, 2228–2233.
    • (2003) Stroke , vol.34 , pp. 2228-2233
    • Marshall, J.W.1    Cummings, R.M.2    Bowes, L.J.3    Ridley, R.M.4    Green, A.R.5
  • 105
    • 33749001683 scopus 로고    scopus 로고
    • On the analysis and interpretation of outcome measures in stroke clinical trials: Lessons from the saint i study of NXY-059 for acute ischemic stroke
    • Koziol, J.A.; Feng, A.C. On the analysis and interpretation of outcome measures in stroke clinical trials: Lessons from the saint i study of NXY-059 for acute ischemic stroke. Stroke 2006, 37, 2644–2647.
    • (2006) Stroke , vol.37 , pp. 2644-2647
    • Koziol, J.A.1    Feng, A.C.2
  • 106
    • 34247643171 scopus 로고    scopus 로고
    • Clinical impact of NXY-059 demonstrated in the saint I trial: Derivation of number needed to treat for benefit over entire range of functional disability
    • Saver, J.L. Clinical impact of NXY-059 demonstrated in the saint I trial: Derivation of number needed to treat for benefit over entire range of functional disability. Stroke 2007, 38, 1515–1518.
    • (2007) Stroke , vol.38 , pp. 1515-1518
    • Saver, J.L.1
  • 107
    • 33747189497 scopus 로고    scopus 로고
    • NXY-059: Brain or vessel protection
    • Fisher, M.; Lees, K.; Papadakis, M.; Buchan, A.M. NXY-059: Brain or vessel protection. Stroke 2006, 37, 2189–2190.
    • (2006) Stroke , vol.37 , pp. 2189-2190
    • Fisher, M.1    Lees, K.2    Papadakis, M.3    Buchan, A.M.4
  • 108
    • 2542436923 scopus 로고    scopus 로고
    • Research and development of the free radical scavenger edaravone as a neuroprotectant
    • Watanabe, T.; Tanaka, M.; Watanabe, K.; Takamatsu, Y.; Tobe, A. Research and development of the free radical scavenger edaravone as a neuroprotectant. Yakugaku Zasshi 2004, 124, 99–111.
    • (2004) Yakugaku Zasshi , vol.124 , pp. 99-111
    • Watanabe, T.1    Tanaka, M.2    Watanabe, K.3    Takamatsu, Y.4    Tobe, A.5
  • 109
    • 77953648503 scopus 로고    scopus 로고
    • A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy?
    • Lapchak, P.A. A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy? Exp. Opin. Pharmacother. 2010, 11, 1753–1763.
    • (2010) Exp. Opin. Pharmacother. , vol.11 , pp. 1753-1763
    • Lapchak, P.A.1
  • 110
    • 65649115845 scopus 로고    scopus 로고
    • Edaravone for the treatment of acute cerebral infarction: Role of endothelium-derived nitric oxide and oxidative stress
    • Higashi, Y. Edaravone for the treatment of acute cerebral infarction: Role of endothelium-derived nitric oxide and oxidative stress. Exp. Opin. Pharmacother. 2009, 10, 323–331.
    • (2009) Exp. Opin. Pharmacother. , vol.10 , pp. 323-331
    • Higashi, Y.1
  • 111
    • 0028292964 scopus 로고
    • Protective effects of MCI-186 on cerebral-ischemia—Possible involvement of free-radical scavenging and antioxidant actions
    • Watanabe, T.; Yuki, S.; Egawa, M.; Nishi, H. Protective effects of MCI-186 on cerebral-ischemia—Possible involvement of free-radical scavenging and antioxidant actions. J. Pharmacol. Exp. Ther. 1994, 268, 1597–1604.
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , pp. 1597-1604
    • Watanabe, T.1    Yuki, S.2    Egawa, M.3    Nishi, H.4
  • 112
    • 0034730419 scopus 로고    scopus 로고
    • MCI-186: Further histochemical and biochemical evidence of neuroprotection
    • Wu, T.W.; Zeng, L.H.; Wu, J.; Fung, K.P. MCI-186: Further histochemical and biochemical evidence of neuroprotection. Life Sci. 2000, 67, 2387–2392.
    • (2000) Life Sci. , vol.67 , pp. 2387-2392
    • Wu, T.W.1    Zeng, L.H.2    Wu, J.3    Fung, K.P.4
  • 113
    • 0036281518 scopus 로고    scopus 로고
    • Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils
    • Jin, Y.J.; Mima, T.; Raicu, V.; Park, K.C.; Shimizu, K. Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. Neurosci. Res. 2002, 43, 75–79.
    • (2002) Neurosci. Res. , vol.43 , pp. 75-79
    • Jin, Y.J.1    Mima, T.2    Raicu, V.3    Park, K.C.4    Shimizu, K.5
  • 114
    • 84880178138 scopus 로고    scopus 로고
    • Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model
    • Ikeda, S.; Harada, K.; Ohwatashi, A.; Kamikawa, Y. Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model. Sci. World J. 2013, 2013, 175280.
    • (2013) Sci. World J. , vol.2013 , pp. 175280
    • Ikeda, S.1    Harada, K.2    Ohwatashi, A.3    Kamikawa, Y.4
  • 115
    • 0037229213 scopus 로고    scopus 로고
    • Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction—Randomized, placebo-controlled, double-blind study at multicenters
    • Otomo, E.; Tohgi, H.; Kogure, K.; Hirai, S.; Takakura, K.; Terashi, A.; Gotoh, F.; Maruyama, S.; Tazaki, Y.; Shinohara, Y. et al. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction—Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovas. Dis. 2003, 15, 222–229.
    • (2003) Cerebrovas. Dis , vol.15 , pp. 222-229
    • Otomo, E.1    Tohgi, H.2    Kogure, K.3    Hirai, S.4    Takakura, K.5    Terashi, A.6    Gotoh, F.7    Maruyama, S.8    Tazaki, Y.9    Shinohara, Y.10
  • 117
    • 79953103571 scopus 로고    scopus 로고
    • Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke
    • Nakase, T.; Yoshioka, S.; Suzuki, A. Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke. BMC Neurol. 2011, 11, 39.
    • (2011) BMC Neurol , vol.11 , pp. 39
    • Nakase, T.1    Yoshioka, S.2    Suzuki, A.3
  • 118
    • 4644360633 scopus 로고    scopus 로고
    • Oxidants, antioxidants and the ischemic brain
    • Warner, D.S.; Sheng, H.; Batinic-Haberle, I. Oxidants, antioxidants and the ischemic brain. J. Exp. Biol. 2004, 207, 3221–3231.
    • (2004) J. Exp. Biol. , vol.207 , pp. 3221-3231
    • Warner, D.S.1    Sheng, H.2    Batinic-Haberle, I.3
  • 119
    • 67349272295 scopus 로고    scopus 로고
    • Neuroprotective effect of adenoviral catalase gene transfer in cortical neuronal cultures
    • Gaspar, T.; Domoki, F.; Lenti, L.; Institoris, A.; Snipes, J.A.; Bari, F.; Busija, D.W. Neuroprotective effect of adenoviral catalase gene transfer in cortical neuronal cultures. Brain Res. 2009, 1270, 1–9.
    • (2009) Brain Res , vol.1270 , pp. 1-9
    • Gaspar, T.1    Domoki, F.2    Lenti, L.3    Institoris, A.4    Snipes, J.A.5    Bari, F.6    Busija, D.W.7
  • 121
    • 1542327575 scopus 로고    scopus 로고
    • Catalase over-expression protects striatal neurons from transient focal cerebral ischemia
    • Gu, W.; Zhao, H.; Yenari, M.A.; Sapolsky, R.M.; Steinberg, G.K. Catalase over-expression protects striatal neurons from transient focal cerebral ischemia. Neuroreport 2004, 15, 413–416.
    • (2004) Neuroreport , vol.15 , pp. 413-416
    • Gu, W.1    Zhao, H.2    Yenari, M.A.3    Sapolsky, R.M.4    Steinberg, G.K.5
  • 122
    • 0031884257 scopus 로고    scopus 로고
    • Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage
    • Weisbrot-Lefkowitz, M.; Reuhl, K.; Perry, B.; Chan, P.H.; Inouye, M.; Mirochnitchenko, O. Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage. Brain Res. Mol. Brain Res. 1998, 53, 333–338.
    • (1998) Brain Res. Mol. Brain Res. , vol.53 , pp. 333-338
    • Weisbrot-Lefkowitz, M.1    Reuhl, K.2    Perry, B.3    Chan, P.H.4    Inouye, M.5    Mirochnitchenko, O.6
  • 124
    • 0034801462 scopus 로고    scopus 로고
    • Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (GPX-1) knockout mouse brain in response to ischemia/reperfusion injury
    • Crack, P.J.; Taylor, J.M.; Flentjar, N.J.; de Haan, J.; Hertzog, P.; Iannello, R.C.; Kola, I. Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (GPX-1) knockout mouse brain in response to ischemia/reperfusion injury. J. Neurochem. 2001, 78, 1389–1399.
    • (2001) J. Neurochem. , vol.78 , pp. 1389-1399
    • Crack, P.J.1    Taylor, J.M.2    Flentjar, N.J.3    De Haan, J.4    Hertzog, P.5    Iannello, R.C.6    Kola, I.7
  • 125
    • 0034655765 scopus 로고    scopus 로고
    • The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice
    • Fujimura, M.; Morita-Fujimura, Y.; Noshita, N.; Sugawara, T.; Kawase, M.; Chan, P.H. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 2000, 20, 2817–2824.
    • (2000) J. Neurosci. , vol.20 , pp. 2817-2824
    • Fujimura, M.1    Morita-Fujimura, Y.2    Noshita, N.3    Sugawara, T.4    Kawase, M.5    Chan, P.H.6
  • 126
    • 0031304166 scopus 로고    scopus 로고
    • Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in cuzn-superoxide dismutase gene knockout mutant mice
    • Kondo, T.; Reaume, A.G.; Huang, T.T.; Murakami, K.; Carlson, E.; Chen, S.; Scott, R.W.; Epstein, C.J.; Chan, P.H. Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in cuzn-superoxide dismutase gene knockout mutant mice. Brain Edema X 1997, 70, 62–64.
    • (1997) Brain Edema X , vol.70 , pp. 62-64
    • Kondo, T.1    Reaume, A.G.2    Huang, T.T.3    Murakami, K.4    Carlson, E.5    Chen, S.6    Scott, R.W.7    Epstein, C.J.8    Chan, P.H.9
  • 127
    • 33750978434 scopus 로고    scopus 로고
    • Gene therapy using SOD1 protects striatal neurons from experimental stroke
    • Davis, A.S.; Zhao, H.; Sun, G.H.; Sapolsky, R.M.; Steinberg, G.K. Gene therapy using SOD1 protects striatal neurons from experimental stroke. Neurosci. Lett. 2007, 411, 32–36.
    • (2007) Neurosci. Lett. , vol.411 , pp. 32-36
    • Davis, A.S.1    Zhao, H.2    Sun, G.H.3    Sapolsky, R.M.4    Steinberg, G.K.5
  • 128
    • 0032889085 scopus 로고    scopus 로고
    • Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia
    • Sheng, H.; Bart, R.D.; Oury, T.D.; Pearlstein, R.D.; Crapo, J.D.; Warner, D.S. Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neuroscience 1999, 88, 185–191.
    • (1999) Neuroscience , vol.88 , pp. 185-191
    • Sheng, H.1    Bart, R.D.2    Oury, T.D.3    Pearlstein, R.D.4    Crapo, J.D.5    Warner, D.S.6
  • 129
    • 0029177589 scopus 로고
    • Oxidative modification of cupro-zinc superoxide dismutase by reactive oxygen species
    • Li, P.F. Oxidative modification of cupro-zinc superoxide dismutase by reactive oxygen species. Sheng Li Ke Xue Jin Zhan 1995, 26, 50–52.
    • (1995) Sheng Li Ke Xue Jin Zhan , vol.26 , pp. 50-52
    • Li, P.F.1
  • 130
    • 0036304614 scopus 로고    scopus 로고
    • Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid
    • Kim, G.W.; Chan, P.H. Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid. J. Cereb. Blood Flow Metab. 2002, 22, 798–809.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 798-809
    • Kim, G.W.1    Chan, P.H.2
  • 131
  • 132
    • 85041566231 scopus 로고    scopus 로고
    • STAT3 regulates the transcription of the mouse Mn-SOD gene as a neuroprotectant in cerebral ischemic reperfusion
    • Jung, J.E.; Kim, G.S.; Narasimhan, P.; Chan, P.H. STAT3 regulates the transcription of the mouse Mn-SOD gene as a neuroprotectant in cerebral ischemic reperfusion. J. Cereb. Blood Flow Metab. 2009, 29, S565–S566.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. S565-S566
    • Jung, J.E.1    Kim, G.S.2    Narasimhan, P.3    Chan, P.H.4
  • 133
    • 84856209632 scopus 로고    scopus 로고
    • Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke
    • Jung, J.E.; Kim, G.S.; Chan, P.H. Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. Stroke 2011, 42, 3574–3579.
    • (2011) Stroke , vol.42 , pp. 3574-3579
    • Jung, J.E.1    Kim, G.S.2    Chan, P.H.3
  • 134
    • 0034884323 scopus 로고    scopus 로고
    • Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
    • Namura, S.; Nagata, I.; Takami, S.; Masayasu, H.; Kikuchi, H. Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 2001, 32, 1906–1911.
    • (2001) Stroke , vol.32 , pp. 1906-1911
    • Namura, S.1    Nagata, I.2    Takami, S.3    Masayasu, H.4    Kikuchi, H.5
  • 135
    • 0034821411 scopus 로고    scopus 로고
    • Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia
    • Imai, H.; Masayasu, H.; Dewar, D.; Graham, D.I.; Macrae, I.M. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke 2001, 32, 2149–2154.
    • (2001) Stroke , vol.32 , pp. 2149-2154
    • Imai, H.1    Masayasu, H.2    Dewar, D.3    Graham, D.I.4    Macrae, I.M.5
  • 136
    • 0030734080 scopus 로고    scopus 로고
    • Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion
    • Takasago, T.; Peters, E.E.; Graham, D.I.; Masayasu, H.; Macrae, I.M. Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. Br. J. Pharmacol. 1997, 122, 1251–1256.
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 1251-1256
    • Takasago, T.1    Peters, E.E.2    Graham, D.I.3    Masayasu, H.4    Macrae, I.M.5
  • 137
    • 0031963836 scopus 로고    scopus 로고
    • Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. Ebselen study group
    • Yamaguchi, T.; Sano, K.; Takakura, K.; Saito, I.; Shinohara, Y.; Asano, T.; Yasuhara, H. Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial. Ebselen study group. Stroke 1998, 29, 12–17.
    • (1998) Stroke , vol.29 , pp. 12-17
    • Yamaguchi, T.1    Sano, K.2    Takakura, K.3    Saito, I.4    Shinohara, Y.5    Asano, T.6    Yasuhara, H.7
  • 139
    • 0036308716 scopus 로고    scopus 로고
    • Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion
    • Singhal, A.B.; Wang, X.; Sumii, T.; Mori, T.; Lo, E.H. Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J. Cereb. Blood Flow Metab. 2002, 22, 861–868.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 861-868
    • Singhal, A.B.1    Wang, X.2    Sumii, T.3    Mori, T.4    Lo, E.H.5
  • 140
    • 0037177102 scopus 로고    scopus 로고
    • Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
    • Singhal, A.B.; Dijkhuizen, R.M.; Rosen, B.R.; Lo, E.H. Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 2002, 58, 945–952.
    • (2002) Neurology , vol.58 , pp. 945-952
    • Singhal, A.B.1    Dijkhuizen, R.M.2    Rosen, B.R.3    Lo, E.H.4
  • 141
    • 84884154937 scopus 로고    scopus 로고
    • Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats
    • Esposito, E.; Mandeville, E.T.; Hayakawa, K.; Singhal, A.B.; Lo, E.H. Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp. Neurol. 2013, 249, 33–38.
    • (2013) Exp. Neurol. , vol.249 , pp. 33-38
    • Esposito, E.1    Mandeville, E.T.2    Hayakawa, K.3    Singhal, A.B.4    Lo, E.H.5
  • 142
    • 16344381726 scopus 로고    scopus 로고
    • Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia
    • Kim, H.Y.; Singhal, A.B.; Lo, E.H. Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann. Neurol. 2005, 57, 571–575.
    • (2005) Ann. Neurol. , vol.57 , pp. 571-575
    • Kim, H.Y.1    Singhal, A.B.2    Lo, E.H.3
  • 143
    • 84876822612 scopus 로고    scopus 로고
    • Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism
    • Geng, X.; Fu, P.; Ji, X.; Peng, C.; Fredrickson, V.; Sy, C.; Meng, R.; Ling, F.; Du, H.; Tan, X. et al. Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism. Stroke 2013, 44, 1418–1425.
    • (2013) Stroke , vol.44 , pp. 1418-1425
    • Geng, X.1    Fu, P.2    Ji, X.3    Peng, C.4    Fredrickson, V.5    Sy, C.6    Meng, R.7    Ling, F.8    Du, H.9    Tan, X.10
  • 145
    • 0028329222 scopus 로고
    • The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia
    • Dalkara, T.; Moskowitz, M.A. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol. 1994, 4, 49–57.
    • (1994) Brain Pathol , vol.4 , pp. 49-57
    • Dalkara, T.1    Moskowitz, M.A.2
  • 147
    • 4544356494 scopus 로고    scopus 로고
    • Ischemic stroke: Acidotoxicity is a perpetrator
    • Huang, Y.; McNamara, J.O. Ischemic stroke: Acidotoxicity is a perpetrator. Cell 2004, 118, 665–666.
    • (2004) Cell , vol.118 , pp. 665-666
    • Huang, Y.1    McNamara, J.O.2
  • 150
    • 0030426710 scopus 로고    scopus 로고
    • Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway
    • Lesage, A.S.; Peeters, L.; Leysen, J.E. Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. J. Pharmacol. Exp. Ther. 1996, 279, 759–766.
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 759-766
    • Lesage, A.S.1    Peeters, L.2    Leysen, J.E.3
  • 151
  • 152
    • 0031013109 scopus 로고    scopus 로고
    • Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide
    • Maiese, K.; TenBroeke, M.; Kue, I. Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide. J. Neurochem. 1997, 68, 710–714.
    • (1997) J. Neurochem. , vol.68 , pp. 710-714
    • Maiese, K.1    Tenbroeke, M.2    Kue, I.3
  • 154
    • 0030175245 scopus 로고    scopus 로고
    • Treatment of experimental focal ischemia in rats with lubeluzole
    • Aronowski, J.; Strong, R.; Grotta, J.C. Treatment of experimental focal ischemia in rats with lubeluzole. Neuropharmacology 1996, 35, 689–693.
    • (1996) Neuropharmacology , vol.35 , pp. 689-693
    • Aronowski, J.1    Strong, R.2    Grotta, J.C.3
  • 155
    • 0030069170 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole international study group
    • Diener, H.C.; Hacke, W.; Hennerici, M.; Radberg, J.; Hantson, L.; de Keyser, J. Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole international study group. Stroke 1996, 27, 76–81.
    • (1996) Stroke , vol.27 , pp. 76-81
    • Diener, H.C.1    Hacke, W.2    Hennerici, M.3    Radberg, J.4    Hantson, L.5    De Keyser, J.6
  • 156
    • 0031438509 scopus 로고    scopus 로고
    • Lubeluzole treatment of acute ischemic stroke. The US and Canadian lubeluzole ischemic stroke study group
    • Grotta, J. Lubeluzole treatment of acute ischemic stroke. The US and Canadian lubeluzole ischemic stroke study group. Stroke 1997, 28, 2338–2346.
    • (1997) Stroke , vol.28 , pp. 2338-2346
    • Grotta, J.1
  • 157
    • 0031923952 scopus 로고    scopus 로고
    • Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke. European and Australian lubeluzole ischaemic stroke study group
    • Diener, H.C. Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke. European and Australian lubeluzole ischaemic stroke study group. Cerebrovasc. Dis 1998, 8, 172–181.
    • (1998) Cerebrovasc. Dis , vol.8 , pp. 172-181
    • Diener, H.C.1
  • 158
    • 0033766740 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-h inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
    • Diener, H.C.; Cortens, M.; Ford, G.; Grotta, J.; Hacke, W.; Kaste, M.; Koudstaal, P.J.; Wessel, T. Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-h inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. Stroke 2000, 31, 2543–2551.
    • (2000) Stroke , vol.31 , pp. 2543-2551
    • Diener, H.C.1    Cortens, M.2    Ford, G.3    Grotta, J.4    Hacke, W.5    Kaste, M.6    Koudstaal, P.J.7    Wessel, T.8
  • 160
    • 0015694842 scopus 로고
    • Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization
    • Weisiger, R.A.; Fridovich, I. Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J. Biol. Chem. 1973, 248, 4793–4796.
    • (1973) J. Biol. Chem. , vol.248 , pp. 4793-4796
    • Weisiger, R.A.1    Fridovich, I.2
  • 161
    • 33846818524 scopus 로고    scopus 로고
    • Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
    • Abramov, A.Y.; Scorziello, A.; Duchen, M.R. Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J. Neurosci. 2007, 27, 1129–1138.
    • (2007) J. Neurosci. , vol.27 , pp. 1129-1138
    • Abramov, A.Y.1    Scorziello, A.2    Duchen, M.R.3
  • 162
    • 84892368437 scopus 로고    scopus 로고
    • Antioxidants as therapies: Can we improve on nature?
    • Murphy, M.P. Antioxidants as therapies: Can we improve on nature? Free Radic. Biol. Med. 2014, 66, 20–23.
    • (2014) Free Radic. Biol. Med. , vol.66 , pp. 20-23
    • Murphy, M.P.1
  • 163
    • 23644441470 scopus 로고    scopus 로고
    • Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems
    • Siler-Marsiglio, K.I.; Pan, Q.; Paiva, M.; Madorsky, F.; Khurana, N.C.; Heaton, M.B. Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems. Brain Res. 2005, 1052, 202–211.
    • (2005) Brain Res , vol.1052 , pp. 202-211
    • Siler-Marsiglio, K.I.1    Pan, Q.2    Paiva, M.3    Madorsky, F.4    Khurana, N.C.5    Heaton, M.B.6
  • 164
    • 4444315545 scopus 로고    scopus 로고
    • Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis
    • Dhanasekaran, A.; Kotamraju, S.; Kalivendi, S.V.; Matsunaga, T.; Shang, T.; Keszler, A.; Joseph, J.; Kalyanaraman, B. Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. J. Biol. Chem. 2004, 279, 37575–37587.
    • (2004) J. Biol. Chem. , vol.279 , pp. 37575-37587
    • Dhanasekaran, A.1    Kotamraju, S.2    Kalivendi, S.V.3    Matsunaga, T.4    Shang, T.5    Keszler, A.6    Joseph, J.7    Kalyanaraman, B.8
  • 165
    • 33847071146 scopus 로고    scopus 로고
    • Targeting antioxidants to mitochondria by conjugation to lipophilic cations
    • Murphy, M.P.; Smith, R.A. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu. Rev. Pharmacol. Toxicol. 2007, 47, 629–656.
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 629-656
    • Murphy, M.P.1    Smith, R.A.2
  • 167
    • 77955283395 scopus 로고    scopus 로고
    • Animal and human studies with the mitochondria-targeted antioxidant mitoq
    • Smith, R.A.; Murphy, M.P. Animal and human studies with the mitochondria-targeted antioxidant mitoq. Ann. N. Y. Acad.Sci. 2010, 1201, 96–103.
    • (2010) Ann. N. Y. Acad.Sci. , vol.1201 , pp. 96-103
    • Smith, R.A.1    Murphy, M.P.2
  • 170
    • 84894067221 scopus 로고    scopus 로고
    • Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function
    • McLachlan, J.; Beattie, E.; Murphy, M.P.; Koh-Tan, C.H.; Olson, E.; Beattie, W.; Dominiczak, A.F.; Nicklin, S.A.; Graham, D. Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. J. Hypertens. 2014, 32, 555–564.
    • (2014) J. Hypertens. , vol.32 , pp. 555-564
    • McLachlan, J.1    Beattie, E.2    Murphy, M.P.3    Koh-Tan, C.H.4    Olson, E.5    Beattie, W.6    Dominiczak, A.F.7    Nicklin, S.A.8    Graham, D.9
  • 171
    • 80053602345 scopus 로고    scopus 로고
    • Protective efficacy of mitochondrial targeted antioxidant mitoq against dichlorvos induced oxidative stress and cell death in rat brain
    • Wani, W.Y.; Gudup, S.; Sunkaria, A.; Bal, A.; Singh, P.P.; Kandimalla, R.J.; Sharma, D.R.; Gill, K.D. Protective efficacy of mitochondrial targeted antioxidant mitoq against dichlorvos induced oxidative stress and cell death in rat brain. Neuropharmacology 2011, 61, 1193–1201.
    • (2011) Neuropharmacology , vol.61 , pp. 1193-1201
    • Wani, W.Y.1    Gudup, S.2    Sunkaria, A.3    Bal, A.4    Singh, P.P.5    Kandimalla, R.J.6    Sharma, D.R.7    Gill, K.D.8
  • 172
    • 50249123948 scopus 로고    scopus 로고
    • Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN
    • Hobbs, C.E.; Murphy, M.P.; Smith, R.A.; Oorschot, D.E. Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN. Pediatr. Int. 2008, 50, 481–488.
    • (2008) Pediatr. Int. , vol.50 , pp. 481-488
    • Hobbs, C.E.1    Murphy, M.P.2    Smith, R.A.3    Oorschot, D.E.4
  • 175
    • 82355191894 scopus 로고    scopus 로고
    • Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive rats
    • Zhang, X.H.; Lei, H.; Liu, A.J.; Zou, Y.X.; Shen, F.M.; Su, D.F. Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive rats. CNS Neurosci. Ther. 2011, 17, 590–598.
    • (2011) CNS Neurosci. Ther. , vol.17 , pp. 590-598
    • Zhang, X.H.1    Lei, H.2    Liu, A.J.3    Zou, Y.X.4    Shen, F.M.5    Su, D.F.6
  • 176
    • 0033805259 scopus 로고    scopus 로고
    • Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a japanese rural community. The shibata study
    • Yokoyama, T.; Date, C.; Kokubo, Y.; Yoshiike, N.; Matsumura, Y.; Tanaka, H. Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a japanese rural community. The shibata study. Stroke 2000, 31, 2287–2294.
    • (2000) Stroke , vol.31 , pp. 2287-2294
    • Yokoyama, T.1    Date, C.2    Kokubo, Y.3    Yoshiike, N.4    Matsumura, Y.5    Tanaka, H.6
  • 177
    • 38149104641 scopus 로고    scopus 로고
    • Plasma vitamin C concentrations predict risk of incident stroke over 10 year in 20,649 participants of the european prospective investigation into cancer norfolk prospective population study
    • Myint, P.K.; Luben, R.N.; Welch, A.A.; Bingham, S.A.; Wareham, N.J.; Khaw, K.T. Plasma vitamin C concentrations predict risk of incident stroke over 10 year in 20,649 participants of the european prospective investigation into cancer norfolk prospective population study. Am. J. Clin. Nutr. 2008, 87, 64–69.
    • (2008) Am. J. Clin. Nutr. , vol.87 , pp. 64-69
    • Myint, P.K.1    Luben, R.N.2    Welch, A.A.3    Bingham, S.A.4    Wareham, N.J.5    Khaw, K.T.6
  • 178
    • 79958251895 scopus 로고    scopus 로고
    • Dietary intakes of antioxidant vitamins and mortality from cardiovascular disease: The Japan collaborative cohort study (JACC) study
    • Kubota, Y.; Iso, H.; Date, C.; Kikuchi, S.; Watanabe, Y.; Wada, Y.; Inaba, Y.; Tamakoshi, A. Dietary intakes of antioxidant vitamins and mortality from cardiovascular disease: The Japan collaborative cohort study (JACC) study. Stroke 2011, 42, 1665–1672.
    • (2011) Stroke , vol.42 , pp. 1665-1672
    • Kubota, Y.1    Iso, H.2    Date, C.3    Kikuchi, S.4    Watanabe, Y.5    Wada, Y.6    Inaba, Y.7    Tamakoshi, A.8
  • 179
    • 0037031094 scopus 로고    scopus 로고
    • MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002, 360, 23–33.
    • (2002) Lancet , vol.360 , pp. 23-33
  • 180
    • 34548040480 scopus 로고    scopus 로고
    • A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: Results from the women’s antioxidant cardiovascular study
    • Cook, N.R.; Albert, C.M.; Gaziano, J.M.; Zaharris, E.; MacFadyen, J.; Danielson, E.; Buring, J.E.; Manson, J.E. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: Results from the women’s antioxidant cardiovascular study. Arch. Intern. Med. 2007, 167, 1610–1618.
    • (2007) Arch. Intern. Med. , vol.167 , pp. 1610-1618
    • Cook, N.R.1    Albert, C.M.2    Gaziano, J.M.3    Zaharris, E.4    Macfadyen, J.5    Danielson, E.6    Buring, J.E.7    Manson, J.E.8
  • 181
    • 56149111693 scopus 로고    scopus 로고
    • Vitamins E and C in the prevention of cardiovascular disease in men: The physicians’ health study II randomized controlled trial
    • Sesso, H.D.; Buring, J.E.; Christen, W.G.; Kurth, T.; Belanger, C.; MacFadyen, J.; Bubes, V.; Manson, J.E.; Glynn, R.J.; Gaziano, J.M. Vitamins E and C in the prevention of cardiovascular disease in men: The physicians’ health study II randomized controlled trial. JAMA 2008, 300, 2123–2133.
    • (2008) JAMA , vol.300 , pp. 2123-2133
    • Sesso, H.D.1    Buring, J.E.2    Christen, W.G.3    Kurth, T.4    Belanger, C.5    Macfadyen, J.6    Bubes, V.7    Manson, J.E.8    Glynn, R.J.9    Gaziano, J.M.10
  • 182
    • 84881317939 scopus 로고    scopus 로고
    • Effects of vitamin E on stroke subtypes: Meta-analysis of randomised controlled trials
    • Schurks, M.; Glynn, R.J.; Rist, P.M.; Tzourio, C.; Kurth, T. Effects of vitamin E on stroke subtypes: Meta-analysis of randomised controlled trials. Br. Med. J. 2010, doi:10.1136/bmj.c5702.
    • (2010) Br. Med. J.
    • Schurks, M.1    Glynn, R.J.2    Rist, P.M.3    Tzourio, C.4    Kurth, T.5
  • 183
    • 79955457391 scopus 로고    scopus 로고
    • The role of vitamin E (Tocopherol) supplementation in the prevention of stroke a meta-analysis of 13 randomised controlled trials
    • Bin, Q.; Hu, X.Y.; Cao, Y.; Gao, F. The role of vitamin E (tocopherol) supplementation in the prevention of stroke a meta-analysis of 13 randomised controlled trials. Thromb. Haemost. 2011, 105, 579–585.
    • (2011) Thromb. Haemost. , vol.105 , pp. 579-585
    • Bin, Q.1    Hu, X.Y.2    Cao, Y.3    Gao, F.4
  • 184
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang, G.L.; Semenza, G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 1995, 270, 1230–1237.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 185
    • 0036211764 scopus 로고    scopus 로고
    • Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain
    • Bernaudin, M.; Nedelec, A.S.; Divoux, D.; MacKenzie, E.T.; Petit, E.; Schumann-Bard, P. Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J. Cereb. Blood Flow Metab. 2002, 22, 393–403.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 393-403
    • Bernaudin, M.1    Nedelec, A.S.2    Divoux, D.3    Mackenzie, E.T.4    Petit, E.5    Schumann-Bard, P.6
  • 186
    • 0034840276 scopus 로고    scopus 로고
    • Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain
    • Jones, N.M.; Bergeron, M. Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain. J. Cereb. Blood Flow Metab. 2001, 21, 1105–1114.
    • (2001) J. Cereb. Blood Flow Metab. , vol.21 , pp. 1105-1114
    • Jones, N.M.1    Bergeron, M.2
  • 189
    • 46249131382 scopus 로고    scopus 로고
    • Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia
    • Wang, X.; Liu, J.; Zhu, H.; Tejima, E.; Tsuji, K.; Murata, Y.; Atochin, D.N.; Huang, P.L.; Zhang, C.; Lo, E.H. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke 2008, 39, 1869–1874.
    • (2008) Stroke , vol.39 , pp. 1869-1874
    • Wang, X.1    Liu, J.2    Zhu, H.3    Tejima, E.4    Tsuji, K.5    Murata, Y.6    Atochin, D.N.7    Huang, P.L.8    Zhang, C.9    Lo, E.H.10
  • 190
    • 78049458153 scopus 로고    scopus 로고
    • Neuroglobin protects neurons against oxidative stress in global ischemia
    • Li, R.C.; Guo, S.Z.; Lee, S.K.; Gozal, D. Neuroglobin protects neurons against oxidative stress in global ischemia. J. Cereb. Blood Flow Metab. 2010, 30, 1874–1882.
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 1874-1882
    • Li, R.C.1    Guo, S.Z.2    Lee, S.K.3    Gozal, D.4
  • 192
    • 78650950140 scopus 로고    scopus 로고
    • Tat-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice
    • Cai, B.; Lin, Y.; Xue, X.H.; Fang, L.; Wang, N.; Wu, Z.Y. Tat-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice. Exp. Neurol. 2011, 227, 224–231.
    • (2011) Exp. Neurol. , vol.227 , pp. 224-231
    • Cai, B.1    Lin, Y.2    Xue, X.H.3    Fang, L.4    Wang, N.5    Wu, Z.Y.6
  • 195
    • 11144258914 scopus 로고    scopus 로고
    • Tissue plasminogen activator neurovascular toxicity is controlled by activated protein c
    • Liu, D.; Cheng, T.; Guo, H.; Fernandez, J.A.; Griffin, J.H.; Song, X.; Zlokovic, B.V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein c. Nat. Med. 2004, 10, 1379–1383.
    • (2004) Nat. Med. , vol.10 , pp. 1379-1383
    • Liu, D.1    Cheng, T.2    Guo, H.3    Fernandez, J.A.4    Griffin, J.H.5    Song, X.6    Zlokovic, B.V.7
  • 197
    • 0034073442 scopus 로고    scopus 로고
    • Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats
    • Asahi, M.; Asahi, K.; Wang, X.; Lo, E.H. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 2000, 20, 452–457.
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 452-457
    • Asahi, M.1    Asahi, K.2    Wang, X.3    Lo, E.H.4
  • 198
    • 0030271381 scopus 로고    scopus 로고
    • Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures
    • Barth, A.; Barth, L.; Newell, D.W. Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures. Exp. Neurol. 1996, 141, 330–336.
    • (1996) Exp. Neurol. , vol.141 , pp. 330-336
    • Barth, A.1    Barth, L.2    Newell, D.W.3
  • 199
    • 84856004974 scopus 로고    scopus 로고
    • Modifying neurorepair and neuroregenerative factors with TPA and edaravone after transient middle cerebral artery occlusion in rat brain
    • Deguchi, K.; Miyazaki, K.; Tian, F.; Liu, N.; Liu, W.; Kawai, H.; Omote, Y.; Kono, S.; Yunoki, T.; Deguchi, S.; et al. Modifying neurorepair and neuroregenerative factors with TPA and edaravone after transient middle cerebral artery occlusion in rat brain. Brain Res. 2012, 1436, 168–177.
    • (2012) Brain Res , vol.1436 , pp. 168-177
    • Deguchi, K.1    Miyazaki, K.2    Tian, F.3    Liu, N.4    Liu, W.5    Kawai, H.6    Omote, Y.7    Kono, S.8    Yunoki, T.9    Deguchi, S.10
  • 200
    • 84862531732 scopus 로고    scopus 로고
    • Prothrombolytic action of normobaric oxygen given alone or in combination with recombinant tissue-plasminogen activator in a rat model of thromboembolic stroke
    • David, H.N.; Haelewyn, B.; Degoulet, M.; Colomb, D.G., Jr.; Risso, J.J.; Abraini, J.H. Prothrombolytic action of normobaric oxygen given alone or in combination with recombinant tissue-plasminogen activator in a rat model of thromboembolic stroke. J. Appl. Physiol. 2012, 112, 2068–2076.
    • (2012) J. Appl. Physiol. , vol.112 , pp. 2068-2076
    • David, H.N.1    Haelewyn, B.2    Degoulet, M.3    Colomb, D.G.4    Risso, J.J.5    Abraini, J.H.6
  • 201
    • 0033596556 scopus 로고    scopus 로고
    • Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia
    • Schmid-Elsaesser, R.; Hungerhuber, E.; Zausinger, S.; Baethmann, A.; Reulen, H.J. Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia. Brain Res. 1999, 816, 471–479.
    • (1999) Brain Res , vol.816 , pp. 471-479
    • Schmid-Elsaesser, R.1    Hungerhuber, E.2    Zausinger, S.3    Baethmann, A.4    Reulen, H.J.5
  • 203
    • 33751327483 scopus 로고    scopus 로고
    • Bench to bedside: The quest for quality in experimental stroke research
    • Dirnagl, U. Bench to bedside: The quest for quality in experimental stroke research. J. Cereb. Blood Flow Metab. 2006, 26, 1465–1478.
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 1465-1478
    • Dirnagl, U.1
  • 204
    • 0344065373 scopus 로고    scopus 로고
    • STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • Stroke Therapy Academic Industry Roundtable (STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1999, 30, 2752–2758.
    • (1999) Stroke , vol.30 , pp. 2752-2758
  • 207
    • 34548475597 scopus 로고    scopus 로고
    • How can we improve the pre-clinical development of drugs for stroke?
    • Sena, E.S.; van der Worp, H.B.; Howells, D.; Macleod, M. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci. 2007, 30, 433–439.
    • (2007) Trends Neurosci , vol.30 , pp. 433-439
    • Sena, E.S.1    Van Der Worp, H.B.2    Howells, D.3    Macleod, M.4
  • 208
    • 67650076487 scopus 로고    scopus 로고
    • Scope of preclinical testing versus quality control within experiments
    • O’Collins, V.E.; Donnan, G.A.; Macleod, M.R.; Howells, D.W. Scope of preclinical testing versus quality control within experiments. Stroke 2009, 40, e497.
    • (2009) Stroke , vol.40
    • O’Collins, V.E.1    Donnan, G.A.2    Macleod, M.R.3    Howells, D.W.4
  • 210
    • 85041813459 scopus 로고    scopus 로고
    • Improving bioscience research reporting: The arrive guidelines for reporting animal research
    • Kilkenny, C.; Browne, W.J.; Cuthill, I.C.; Emerson, M.; Altman, D.G. Improving bioscience research reporting: The arrive guidelines for reporting animal research. PLoS Biol. 2010, 8, e1000412.
    • (2010) Plos Biol , vol.8
    • Kilkenny, C.1    Browne, W.J.2    Cuthill, I.C.3    Emerson, M.4    Altman, D.G.5


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