Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats

Journal of Neuroscience Research

Volumn 86, Issue 11, 2008, Pages 2524-2534

  McCann, Sarah K ^a,b   Dusting, Gregory J ^a,b   Roulston, Carli L ^a,b  

^a Bernard O'Brien Institute of Microsurgery   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

ET 1 induced stroke; NADPH oxidase subunits; Reperfusion; Superoxide

Indexed keywords

BIOLOGICAL MARKER; ENDOTHELIN 1; HYDROETHIDINE; MESSENGER RNA; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONSCIOUSNESS; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVE SITE; FLUORESCENCE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MACROPHAGE; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; REPERFUSION; UPREGULATION;

ANIMALS; BRAIN; CONSCIOUSNESS; ENDOTHELIN-1; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STROKE; SUPEROXIDES; UP-REGULATION;

EID: 49349093647     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21700     Document Type: Article

References (39)

1. Abramov AY, Scorziello A, Duchen MR. 2007. Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J Neurosci 27:1129-1138.
2. Ago T, Kitazono T, Ooboshi H, Iyama T, Han YH, Takada J, Wakisaka M, Ibayashi S, Utsumi H, Iida M. 2004. Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase. Circulation 109:227-233.
3. Bengtsson SH, Gulluyan LM, Dusting GJ, Drummond GR. 2003. Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology. Clin Exp Pharmacol Physiol 30:849-854.
4. Callaway JK, Knight MJ, Watkins DJ, Beart PM, Jarrott B. 1999. Delayed treatment with AM-36, a novel neuroprotective agent, reduces neuronal damage after endothelin-1-induced middle cerebral artery occlusion in conscious rats. Stroke 30:2704-2712; discussion 2712.
5. Callaway JK, Knight MJ, Watkins DJ, Beart PM, Jarrott B, Delaney PM. 2000. A novel, rapid, computerized method for quantitation of neuronal damage in a rat model of stroke. J Neurosci Methods 102:53-60.
6. Chan EC, Drummond GR, Woodman OL. 2003. 3′,4′-Dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat. J Cardiovasc Pharmacol 42:727-735.
7. De Ryck M, Van Reempts J, Borgers M, Wauquier A, Janssen PAJ. 1989. Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 20:1383-1390.
8. Dusting G. 2004. International symposium on nitric oxide, cytokines and inflammation. IDrugs 7:725-728.
9. Ellmark SH, Dusting GJ, Fui MN, Guzzo-Pernell N, Drummond GR. 2005. The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Cardiovasc Res 65:495-504.
10. Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, Rutkowski JL, Finklestein SP, Pangalos MN, Poole M, Stiles GL, Ruffolo RR, Walsh FL. 2007. Missing steps in the STAIR case: a translational medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke. J Cereb Blood Flow Metab (in press).
11. Green SP, Cairns B, Rae J, Errett-Baroncini C, Hongo JA, Erickson RW, Curnutte JT. 2001. Induction of gp91-phox, a component of the phagocyte NADPH oxidase, in microglial cells during central nervous system inflammation. J Cereb Blood Flow Metab 21:374-384.
12. Griendling KK, Sorescu D, Ushio-Fukai M. 2000. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86:494-501.
13. Harada H, Hines IN, Flores S, Gao B, McCord J, Scheerens H, Grisham MB. 2004. Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury. Arch Biochem Biophys 423: 103-108.
14. Jana A, Pahan K. 2004. Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J Biol Chem 279: 51451-51459.
15. Jiang F, Drummond GR, Dusting GJ. 2004. Suppression of oxidative stress in the endothelium and vascular wall. Endothelium 11:79-88.
16. Lee JM, Grabb MC, Zipfel GJ, Choi DW. 2000. Brain tissue responses to ischemia. J Clin Invest 106:723-731.
17. Lipton P. 1999. Ischemic cell death in brain neurons. Physiol Rev 79:1431-1568.
18. Miller AA, Drummond GR, Sobey CG. 2006a. Novel isoforms of NADPH-oxidase in cerebral vascular control. Pharmacol Ther 111: 928-948.
19. Miller AA, Dusting GJ, Roulston CL, Sobey CG. 2006b. NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke. Brain Res 1111:111-116.
20. Nagel S, Genius J, Heiland S, Horstmann S, Gardner H, Wagner S. 2007. Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat. Brain Res 1132:210-217.
21. Oudot A, Vergely C, Ecarnot-Laubriet A, Rochette L. 2003. Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia-reperfusion. Eur J Pharmacol 462:145-154.
22. Paravicini TM, Sobey CG. 2003. Cerebral vascular effects of reactive oxygen species: recent evidence for a role of NADPH-oxidase. Clin Exp Pharmacol Physiol 30:855-859.
23. Paravicini TM, Gulluyan LM, Dusting GJ, Drummond GR. 2002. Increased NADPH oxidase activity, gp91phox expression, and endothelium-dependent vasorelaxation during neointima formation in rabbits. Circ Res 91:54-61.
24. Paravicini TM, Chrissobolis S, Drummond GR, Sobey CG. 2004. Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo. Stroke 35:584-589.
25. Peshavariya HM, Dusting GJ, Selemidis S. 2007. Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase. Free Radic Res 41:699-712.
26. Ritchie RH, Rosenkranz AC, Huynh LP, Stephenson T, Kaye DM, Dusting GJ. 2004. Activation of IP prostanoid receptors prevents cardiomyocyte hypertrophy via cAMP-dependent signaling. Am J Physiol Heart Circ Physiol 287:H1179-H1185.
27. Schaller B. 2005. Prospects for the future: the role of free radicals in the treatment of stroke. Free Radic Biol Med 38:411-425.
28. Schaller B, Graf R. 2004. Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab 24:351-371.
29. Serrano F, Kolluri NS, Wientjes FB, Card JP, Klann E. 2003. NADPH oxidase immunoreactivity in the mouse brain. Brain Res 988:193-198.
30. Sharkey J, Butcher SP. 1995. Characterisation of an experimental model of stroke produced by intracerebral microinjection of endothelin-1 adjacent to the rat middle cerebral artery. J Neurosci Methods 60:125-131.
31. Sharkey J, Ritchie IM, Kelly PAT. 1993. Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in rats. J Cereb Blood Flow Metab 13:865-871.
32. Shichinohe H, Kuroda S, Yasuda H, Ishkawa T, Iwai M, Horiuchi M, Iwasaki Y. 2004. Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Res 1029:200-206.
33. Trushina E, McMurray CT. 2007. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience 145:1233-1248.
34. Vallet P, Charnay Y, Steger K, Ogier-Denis E, Kovari E, Herrmann F, Michel JP, Szanto I. 2005. Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. Neuroscience 132:233-238.
35. Vaziri ND, Lee YS, Lin CY, Lin VW, Sindhu RK. 2004. NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury. Brain Res 995:76-83.
36. Walder CE, Green SP, Darbonne WC, Mathias J, Rae J, Dinauer MC, Curnutte JT, Thomas GR. 1997. Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke 28:2252-2258.
37. Wang Q, Tompkins KD, Simonyi A, Korthuis RJ, Sun AY, Sun GY. 2006. Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 1090:182-189.
38. Yamamoto M, Tamura A, Kirino, T, Shimizu M, Sano K. 1988. Behavioral changes after focal cerebral ischemia by left middle cerebral artery occlusion in rats. Brain Res 452:323-328.
39. Yang S, Madyastha P, Bingel S, Ries W, Key L. 2001. A new superoxide-generating oxidase in murine osteoclasts. J Biol Chem 276:5452-5458.