Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 3, 2000, Pages 452-457

  Asahi, Minoru ^b   Asahi, Kazuko ^b   Wang, Xiaoying ^b   Lo, Eng H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

Cerebral hemorrhage; Oxidative stress; Proteolysis; Reperfusion injury; Stroke; Tissue plasminogen activator

Indexed keywords

ALTEPLASE; FREE RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOT LYSIS; BRAIN EMBOLISM; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MIXTURE; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPIN TRAPPING; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE;

EID: 0034073442     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200003000-00002     Document Type: Article

References (26)

1. Akins PT, Liu PK, Hsu CY (1996) Immediate early gene expression in response to cerebral ischemia: friend or foe? Stroke 27:1682-1687
2. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17: 472-476
3. Brinker G, Pillekamp F, Hossman KA (1999) Brain hemorrhage after rtPA treatment of embolic stroke in spontaneously hypertensive rats. NeuroReport 10:1943-1946
4. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27:1124-1130
5. Chopp M, Zhang RL, Zhang ZG, Jiang Q (1999) The clot thickens: thrombolysis and combination therapies. Acta Neurochir Suppl 73: 67-71
6. Choudri TF, Hoh BL, Solomon RA, Connoly ES, Pinsky D (1997) Use of a spectrophotometric assay to objectively quantify intracerebral hemorrhage in mice. Stroke 28:2296-2302
7. del Zoppo GJ, Zeumer H, Harker LA (1986) Thrombolytic therapy in stroke: possibilities and hazards. Stroke 7:595-607
8. ECASS Study Group (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator in acute hemispheric stroke. JAMA 274:1017-1025
9. Hallenback JM, Dutka AJ (1990) Current concepts of reperfusion injury. Arch Neurol 47:1245-1254
10. Kano T, Katayama Y, Tejima E, Lo EH (1999) Hemorrhagic transformation after fibrinolytic therapy with tissue plasminogen activator in a rat thromboembolic model of stroke. Brain Res (In press)
11. Korninger C, Collen D (1981) Studies on specific fibrinolytic effect of human extrinsic plasminogen activator in human blood and in various animal species in vitro. Thromb Haemost 46:561-565
12. Larrue V, von Kummer R, del Zoppo G, Bluhmki E (1999) Hemor-rhagic transformation in acute ischemic stroke: potential contributing factors in the ECASS study. Stroke 28:957-960
13. Levy DE, Brott TG, C HE, Marier JR, Sheppard GL, Barsan W, Broderick JP (1994) Factors related to intracranial hematoma formation in patients receiving tPA for acute ischemic stroke. Stroke 25:291-297
14. Lo EH, Bosque-Hamilton P, Meng W (1998) Inhibition of PARP: reduction of ischemic injury and attenuation of NMDA-induced neurotransmitter dysregulation. Stroke 29:830-836
15. Lyden PD, Zivin JA (1993) Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence. Cerebrovasc Brain Metab Rev 5:1-16
16. Meng W, Wang X, Asahi M, Kano T, Asahi K, Ackerman RH, Lo EH (1999) Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats. J Cereb Blood Flow Metab 19:1316-1322
17. Newcomb R, Pierce AR, Kano T, Meng W, Bosque-Hamilton P, Taylor L, Curthoys N, Lo EH (1998) Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia. Brain Res 813:103-111
18. NINDS rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. New Engl J Med 333:1581-1587
19. NINDS rt-PA Stroke Study Group (1997) Intracerebral hemorrhage after intravenous TPA therapy for ischemic stroke. Stroke 28: 2109-2118
20. Shimizu-Sasamata M, Bosque-Hamilton P, Huang PL, Moskowitz MA, Lo EH (1998) Attenuated neurotransmitter release and spreading depression like depolarizations after focal ischemia in mutanat mice with disrupted type I nitric oxide synthase gene. J Neurosci 18:9564-9571
21. Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S (1997) An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci 17:543-552
22. Tsirka SE, Rogove AD, Strickland S (1996) Neuronal cell death and TPA. Nature 384:123-124
23. Wang X, Asahi M, Lo EH (1999) Tissue plasminogen activator amplifies hemoglobin induced neurotoxicity in rat neuronal cultures. Neurosci Lett 274:79-82
24. Wang YF, Tsirka SE, Strickland S, Steig PE, Soriano SG, Lipton SA (1998) TPA increases neuronal damage after focal cerebral ischemia in wild type and TPA-deficient mice. Nature Med 4:228-231
25. Zea Longa E, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle artery occlusion without craniectomy. Stroke 20:84-91
26. Zhang ZG, Zhang RL, Jiang Q, Raman SB, Cantwell L, Chopp M (1997) A new rat model of thrombotic focal cerebral ischemia. J Cereb Blood Flow Metab 17:123-135