NXY-059: Brain or vessel protection

Stroke

Volumn 37, Issue 8, 2006, Pages 2189-2190

  Papadakis, Michalis ^a,b   Buchan, Alastair M ^a,b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Neuroprotectants

Indexed keywords

DISUFENTON SODIUM; FREE RADICAL; TISSUE PLASMINOGEN ACTIVATOR; ANTIOXIDANT; BENZENESULFONIC ACID DERIVATIVE; NEUROPROTECTIVE AGENT; NITROGEN OXIDE;

BLOOD BRAIN BARRIER; BLOOD CLOT LYSIS; BLOOD VESSEL; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN ISCHEMIA; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; ENZYME INACTIVATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; ANIMAL; ARTICLE; BRAIN CIRCULATION; CEREBROVASCULAR ACCIDENT; DRUG COMBINATION; FIBRINOLYTIC THERAPY; HUMAN; PATHOPHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; BENZENESULFONATES; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; DRUG THERAPY, COMBINATION; HUMANS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; THROMBOLYTIC THERAPY;

EID: 33747189497     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000230598.31774.7a     Document Type: Short Survey

References (7)

1. Kuroda S, Tsuchidate R, Smith ML, Maples KR, Siesjo BK. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 1999;19:778-787.
2. Sydserff SG, Borelli AR, Green AR, Cross AJ. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br J Pharmacol. 2002;135:103-112.
3. Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, Grotta J, Lyden P, Shuaib A, Hardemark HG, Wasiewski WW. NXY-059 for acute ischemic stroke. N Engl J Med. 2006;354:588-600.
4. Stroke Therapy Academic Industry Roundtable. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30:2752-2758.
5. Dehouck MP, Cecchelli R, Richard GA, Renftel M, Lundquist S. In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions. Brain Res. 2002;955:229-235.
6. del Zoppo GJ. Stroke and neurovascular protection. N Engl J Med. 2006;354:553-555.
7. Green AR, Lanbeck-Vallen K, Ashwood T, Lundquist S, Lindstrom BE, Jonasson H, Campbell M. Bain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia. Brain Res. 2006;1072:224-226.