Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution

Journal of Biological Chemistry

Volumn 284, Issue 4, 2009, Pages 2176-2186

  Soberanes, Saul ^a   Urich, Daniela ^a   Baker, Christina M ^a   Burgess, Zach ^a   Chiarella, Sergio E ^a   Bell, Eric L ^a   Ghio, Andrew J ^b   De Vizcaya Ruiz, Andrea ^c   Liu, Jing ^a   Ridge, Karen M ^a   Kamp, David W ^a   Chandel, Navdeep S ^a   Schumacker, Paul T ^a   Mutlu, Gökhan M ^a   Budinger, G R Scott ^a,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c DEPARTAMENTO DE FÍSICA   (Mexico)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIR POLLUTION; AIR QUALITY; CELL CULTURE; CELL DEATH; CYTOLOGY; DNA; ELECTRON TRANSITIONS; ELECTRON TRANSPORT PROPERTIES; ELECTRONS; MITOCHONDRIA; NUCLEIC ACIDS; ORGANIC ACIDS; OXIDANTS; OXYGEN; PERMANENT MAGNETS; RNA; SULFUR;

AIRBORNE PARTICULATE MATTERS; ALVEOLAR EPITHELIAL CELLS; APOPTOTIC PATHWAYS; DOMINANT NEGATIVES; IN CELLS; IRON-SULFUR PROTEINS; KNOCK OUTS; MITOCHONDRIAL COMPLEXES; MITOCHONDRIAL ELECTRON TRANSPORT CHAINS; MITOCHONDRIAL GENERATIONS; MITOCHONDRIAL OXIDANTS; MOLECULAR LINKS; MURINE EMBRYONIC FIBROBLASTS; OVER EXPRESSIONS; OXIDANT PRODUCTIONS; PARTICULATE MATTER AIR POLLUTIONS; RATIOMETRIC SENSORS; REACTIVE OXYGEN SPECIES;

CELLS;

ADENOVIRUS VECTOR; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS SIGNAL REGULATING KINASE 1; COPPER ZINC SUPEROXIDE DISMUTASE; IRON SULFUR PROTEIN; MITOCHONDRIAL DNA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; UBIQUINOL CYTOCHROME C REDUCTASE;

AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPILLARY PERMEABILITY; CELL DEATH; CONTROLLED STUDY; FIBROBLAST; KNOCKOUT MOUSE; LUNG ALVEOLUS EPITHELIUM; MALE; MOUSE; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN;

AIR POLLUTANTS; ANIMALS; APOPTOSIS; CELLS, CULTURED; ELECTRON TRANSPORT COMPLEX III; ENZYME ACTIVATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE KINASE 5; MICE; MITOCHONDRIA; OXIDANTS; PULMONARY ALVEOLI; RATS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

ADENOVIRIDAE; MURINAE; MUS;

EID: 59049090581     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808844200     Document Type: Article

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