The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 11, 2000, Pages 1529-1536

  McCracken, E ^a   Valeriani, V ^a   Simpson, C ^a   Jover, T ^a   McCulloch, J ^a   Dewar, D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Free radicals; Ischemia; Oxidative damage; White matter

Indexed keywords

4 HYDROXYNONENAL; AMYLOID PRECURSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN VENTRICLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INJECTION SITE; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL LESION; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; OXIDATIVE STRESS; PERIKARYON; PRIORITY JOURNAL; RAT; WHITE MATTER;

EID: 0033756824     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200011000-00002     Document Type: Article

References (45)

1. 4-Hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes
2. Central nervous system trauma and stroke 1: Biochemical considerations for oxygen radical formation and lipid peroxidation
3. 4-Hydroxynonenal a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats
4. Oxygen radicals in focal cerebral ischaemia
5. Biology of disease lipid peroxidation and cellular damage in toxic liver injury
6. Three models of free radical induced cell injury
7. The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein
8. Tau-protein is altered by focal cerebralischaemia in the rat brain-an immunohistochemical and immunoblotting study
9. Changes in cytoskeletal protein immunostaining in myelinated fibre tracts after focal cerebral ischaemia in the rat
10. Drug development for stroke: Importance of protecting cerebral white matter
11. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
12. Free radicals in cerebral ischaemia
13. β-Amyloid precursor protein (β-APP) as a marker for axonal injury after head injury
14. Trauma to the corpus callosum: MR features
15. Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: Relevance to human brain injury
16. Intraventricular infusion of apolipoprotein E ameliorates acute neuronal damage after global cerebral ischemia in mice
17. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate and mitochondrial function in synaptosomes
18. Precursor of amyloid protein in Alzheimer's disease undergoes fast anterograde axonal transport
19. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
20. Novel injury mechanism in anoxia and trauma of spinal cord white matter: Glutamate release via reverse Na+-dependent glutamate transport
21. Reversible middle cerebral artery occlusion without craniectomy in rats
22. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide
23. 4-Hydroxynonenal, a lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau
24. Modification of ion homeostasis by lipid peroxidation: Roles in neuronal degeneration and adaptive plasticity
25. Ultrastructural evidence of axonal shearing as a result of lateral acceleration of the head in non-human priamtes
26. Preparation of separate astroglia and oligodendroglia cell cultures from rat cerebral tissue
27. Calpain activation and cytoskeletal protein breakdown in the corpus callosum of head-injured patients
28. E-4-hydroxynonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglia cultures
29. The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth neuronal microtubules, and modifies cellular tubulin
30. A mechanism for the neuroprotective effect of apolipoprotein E: Isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal
31. 4-Hydroxy-2 (E)-nonenal inhibits CNS mitochondrial respiration at multpile sites
32. Neurofilament 68 and neurofilament 200 protein levels decrease after traumatic brain injury
33. Peroxynitrite-induced membrane lipid peroxidation the cytotoxic potential of superoxide and nitric oxide
34. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation derivatives
35. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat
36. Free radicals, antioxidants and reperfusion injury in the CNS
37. +-ATPase
38. 4-Hydroxynonenal, a lipid peroxidation, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake
39. Anoxic and ischemic injury of myelinated axons in CNS white matter: From mechanistic concepts to therapeutics
40. The lipid peroxidation product, 4-hydroxy-2-transnonenal, alters the conformation of cortical synaptosomal membrane proteins
41. Colocalisation of Bcl-2 and 4-hydroxynonenal modified proteins in microglia cells and neurons of rat brain following transient ischaemia
42. Quantitative assessment of ischemic pathology in axons, oligodendrocytes and neurons: Attenuation of damage after transient ischemia
43. Amyloid precursor protein accumulates in white matter at the margin of a focal ischemic lesion
44. Axonal injury caused by focal cerebral ischaemia in the rat
45. Immunohistochemical detection of the lipid peroxidation product 4-hydroxynonenal after experimental brain injury in the rat