Oxidants, antioxidants and the ischemic brain

Journal of Experimental Biology

Volumn 207, Issue 18, 2004, Pages 3221-3231

  Warner, David S ^a   Sheng, Huaxin ^a   Batinić Haberle, Ines ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antioxidant; Brain; Ischemia; Oxidative stress

Indexed keywords

ANTIOXIDANT; CARRIER PROTEIN; CATALASE; CHELATING AGENT; GLUTATHIONE PEROXIDASE; ION CHANNEL; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

APOPTOSIS; BRAIN ISCHEMIA; DNA DAMAGE; HUMAN; LIPID PEROXIDATION; METABOLISM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SPIN TRAPPING;

ANTIOXIDANTS; APOPTOSIS; BRAIN ISCHEMIA; CATALASE; CHELATING AGENTS; DNA DAMAGE; GLUTATHIONE PEROXIDASE; HUMANS; ION CHANNELS; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NITRIC OXIDE SYNTHASE; OXIDANTS; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; SPIN TRAPPING; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

EID: 4644360633     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: 10.1242/jeb.01022     Document Type: Review

References (162)

1. Abdelkarim, G. E., Gertz, K., Harms, C., Katchanov, J., Dirnagl, U., Szabo, C. and Endres, M. (2001). Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int. J. Mol. Med. 7, 255-260.
2. Amin-Hanjani, S., Stagliano, N. E., Yamada, M., Huang, P. L., Liao, J. K. and Moskowitz, M. A. (2001). Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 32, 980-986.
3. Baker, K., Bucay Marcus, C., Huffman, K., Kruk, H., Malfroy, B. and Doctrow, S. R. (1998). Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284, 215-221.
4. Batinic-Haberle, I. (2002). Manganese porphyrins and related compounds as mimics of superoxide dismutase. Methods Enzymol. 349, 223-233.
5. 2.- dismutation. J. Chem. Soc. Dalton Trans. 2689-2696.
6. Bazan, N. G., Jr (1970). Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim. Biophys. Acta 218, 1-10.
7. Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A. and Freeman, B. A. (1990). Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87, 1620-1624.
8. Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P. and Lipton, S. A. (1995). Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92, 7162-7166.
9. Bowler, R. P., Sheng, H., Enghild, J. J., Pearlstein, R. D., Warner, D. S. and Crapo, J. D. (2002). A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Free Rad. Biol. Med. 33, 1141-1152.
10. Britigan, B. E., Roeder, T. L. and Buettner, G. R. (1991). Spin traps inhibit formation of hydrogen peroxide via the dismutation of superoxide: implications for spin trapping the hydroxyl free radical. Biochim. Biophys. Acta 1075, 213-222.
11. Brookes, P. S., Land, J. M., Clark, J. B. and Heales, S. J. (1998). Peroxynitrite and brain mitochondria: evidence for increased proton leak. J. Neurochem. 70, 2195-2202.
12. Brown, G. C. and Borutaite, V. (1999). Nitric oxide, cytochrome c and mitochondria. Biochem. Soc. Symp. 66, 17-25.
13. Chan, P. H., Kamii, H., Yang, G. Y., Gafni, J., Epstein, C. J., Carlson, E. and Reola, L. (1993). Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia. NeuroReport 5, 293-296.
14. Chen, X., Mele, J., Giese, H., Van Remmen, H., Dolle, M. E., Steinhelper, M., Richardson, A. and Vijg, J. (2003). A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech. Ageing Dev. 124, 219-227.
15. Chiueh, C. C. (1999). Neuroprotective properties of nitric oxide. Ann. NY Acad. Sci. 890, 301-311.
16. Crack, P. J., Taylor, J. M., Flentjar, N. J., de Haan, J., Hertzog, P., Iannello, R. C. and Kola, I. (2001). Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J. Neurochem. 78, 1389-1399.
17. Dawson, V. L., Dawson, T. M., London, E. D., Bredt, D. S. and Snyder, S. H. (1991). Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88, 6368-6371.
18. Day, B. J., Fridovich, I. and Crapo, J. D. (1997). Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch. Biochem. Biophys. 347, 256-262.
19. Ding, Y., Zhou, Y., Lai, Q., Li, J., Gordon, V. and Diaz, F. G. (2001). Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment. Brain Res. 915, 210-217.
20. Eliasson, M. J. L., Huang, Z. H. and Ferrante, R. J. (1999). Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage. J. Neurosci. 19, 5910-5918.
21. Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Wang, Z. Q., Dawson, T. M., Snyder, S. H. et al. (1997). Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nature Med. 3, 1089-1095.
22. Endres, M., Laufs, U., Huang, Z., Nakamura, T., Huang, P., Moskowitz, M. A. and Liao, J. K. (1998). Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 95, 8880-8885.
23. Espey, M. G., Miranda, K. M., Feelisch, M., Fukuto, J., Grisham, M. B., Vitek, M. P. and Wink, D. A. (2000). Mechanism of cell death governed by the balance between nitrosative and oxidative stress. Ann. NY Acad. Sci. 899, 209-221.
24. Fabian, R. H., DeWitt, D. S. and Kent, T. A. (1995). In vivo detection of superoxide anion production by the brain using a cytochrome c electrode. J. Cereb. Blood Metab. 15, 242-247.
25. Ferrer-Sueta, G., Vitturi, D., Batinic-Haberle, I., Fridovich, I., Goldstein, S., Czapski, G. and Radi, R. (2003). Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. 278, 27432-27438.
26. Flamm, E. S., Demopoulos, H. B., Seligman, M. L., Poser, R. G. and Ransohoff, J. (1978). Free radicals in cerebral ischemia. Stroke 9, 445-447.
27. Fleischer, J. E., Lanier, W. L., Milde, J. H. and Michenfelder, J. D. (1987). Failure of deferoxamine, an iron chelator, to improve neurologic outcome following complete cerebral ischemia in dogs. Stroke 18, 124-127.
28. Forsman, M., Fleischer, J. E., Milde, J. H., Steen, P. A. and Michenfelder, J. D. (1988). Superoxide dismutase and catalase failed to improve neurologic outcome after complete cerebral ischemia in the dog. Acta Anaesthesiol. Scand. 32, 152-155.
29. Friberg, H. and Wieloch, T. (2002). Mitochondrial permeability transition in acute neurodegeneration. Biochimie 84, 241-250.
30. Fridovich, I. (1995). Superoxide radical and superoxide dismutases. Annu. Rev. Biochem. 64, 97-112.
31. Fridovich, I. (2003). Editorial commentary on 'superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide' by H. Zhao et al. Free Rad. Biol. Med. 34, 1357-1358.
32. Fujimura, M., Morita-Fujimura, Y., Copin, J., Yoshimoto, T. and Chan, P. H. (2001). Reduction of copper,zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia. Brain Res. 889, 208-213.
33. Fujimura, M., Morita-Fujimura, Y., Narasimhan, P., Copin, J. C., Kawase, M. and Chan, P. H. (1999). Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 30, 2408-2415.
34. Fujimura, M., Morita-Fujimura, Y., Noshita, N., Sugawara, T., Kawase, M. and Chan, P. H. (2000). The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 20, 2817-2824.
35. Fukui, S., Ookawara, T., Nawashiro, H., Suzuki, K. and Shima, K. (2002). Post-ischemic transcriptional and translational responses of EC-SOD in mouse brain and serum. Free Rad. Biol. Med. 32, 289-298.
36. Fullerton, H. J., Ditelberg, J. S., Chen, S. F., Sarco, D. P., Chan, P. H., Epstein, C. J. and Ferriero, D. M. (1998). Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann. Neurol. 44, 357-364.
37. Gardner, P. R. and Fridovich, I. (1991). Superoxide sensitivity of the Escherichia coli aconitase. J. Biol. Chem. 266, 19328-19333.
38. Gardner, P. R., Martin, L. A., Hall, D. and Gardner, A. M. (2001). Dioxygen-dependent metabolism of nitric oxide in mammalian cells. Free Rad. Biol. Med. 31, 191-204.
39. Garthwaite, J., Charles, S. L. and Chess-Williams, R. (1988). Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336, 385-388.
40. Garthwaite, J., Garthwaite, G., Palmer, R. M. J. and Moncada, S. (1989). NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur. J. Pharmacol. 172, 413-416.
41. Gaudet, R. J., Alam, I. and Levine, L. (1980). Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J. Neurochem. 35, 653-658.
42. Giovannelli, L., Cozzi, A., Guarnieri, I., Dolara, P. and Moroni, F. (2002). Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. J. Cereb. Blood Flow Metab. 22, 697-704.
43. Glebska, J. and Koppenol, W. H. (2003). Peroxynitrite-mediated oxidation of dihydrodichlorofluorescein and dihydrorhodamine. Free Rad. Biol. Med. 35, 676-682.
44. Globus, M. Y. T., Busto, R., Lin, B., Schnippering, H. and Ginsberg, M. D. (1995). Detection of free radical activity during transient global ischemia and recirculation: Effects of intraischemic brain temperature modulation. J. Neurochem. 65, 1250-1256.
45. Goldstein, S., Merenyi, G., Russo, A. and Samuni, A. (2003a). The role of oxoammonium cation in the SOD-mimic activity of cyclic nitroxides. J. Am. Chem. Soc. 125, 789-795.
46. Goldstein, S., Samuni, A. and Merenyi, G. (2004). Reactions of nitric oxide, peroxynitrite, and carbonate radicals with nitroxides and their corresponding oxoammonium cations. Chem. Res. Toxicol. 17, 250-257.
47. Goldstein, S., Samuni, A. and Russo, A. (2003b). Reaction of cyclic nitroxides with nitrogen dioxide the intermediacy of the oxoammonium cations. J. Am. Chem. Soc. 125, 8364-8370.
48. Gotoh, O., Yamamoto, M., Tamura, A. and Sano, K. (1994). Effect of YM737, a new glutathione analogue, on ischemic brain edema. Acta Neurochir. Suppl. (Wien) 60, 318-320.
49. Haley, E. C., Jr (1998). High-dose tirilazad for acute stroke (RANTTAS II). RANTTAS II Investigators. Stroke 29, 1256-1257.
50. Halliwell, B. and Gutteridge, J. M. C. (1999). Free Radicals in Biology and Medicine. Oxford: Oxford University Press.
51. Han, H. S., Qiao, Y., Karabiyikoglu, M., Giffard, R. G. and Yenari, M. A. (2002). Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J. Neurosci. 22, 3921-3928.
52. Hashiguchi, A., Yano, S., Moriko, M., Hamada, J., Ushio, Y., Takeuchi, Y. and Fukunaga, K. (2004). Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol 3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil hippocampus. J. Cereb. Blood Flow Metab. 24, 271-279.
53. Hausladen, A., Gow, A. J. and Stamler, J. S. (1998). Nitrosative stress: Metabolic pathway involving the flavohemoglobin. Proc. Natl. Acad. Sci. USA 95, 14100-14105.
54. Huang, Z., Huang, P. L., Panahian, N., Dalkara, T., Fishman, M. C. and Moskowitz, M. A. (1994). Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265, 1883-1885.
55. Hurn, P. D., Koehler, R. C., Blizzard, K. K. and Traystman, R. J. (1995). Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs. Stroke 26, 688-694; Discussion 694-695.
56. Ibrahim, W., Lee, U. S., Yen, H. C., St Clair, D. K. and Chow, C. K. (2000). Antioxidant and oxidative status in tissues of manganese superoxide dismutase transgenic mice. Free Rad. Biol. Med. 28, 397-402.
57. Ignarro, L. J., Byrns, R. E., Buga, G. M. and Wood, K. S. (1987). Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacological and chemical properties identical to those of nitric oxide radical. Circ. Res. 61, 866-879.
58. Imai, H., Graham, D. I., Masayasu, H. and Macrae, I. M. (2003). Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. Free Rad. Biol. Med. 34, 56-63.
59. Imaizumi, S., Tominaga, T., Uenohara, H., Yoshimoto, T., Suzuki, J. and Fujita, Y. (1986). Initiation and propagation of lipid peroxidation in cerebral infarction models. Experimental studies. Neurol. Res. 8, 214-220.
60. Ishibashi, N., Prokopenko, O., Weisbrot-Lefkowitz, M., Reuhl, K. R. and Mirochnitchenko, O. (2002). Glutathione peroxidase inhibits cell death and glial activation following experimental stroke. Brain Res. Mol. Brain Res. 109, 34-44.
61. Joshi, M. S., Ferguson, T. B., Jr, Han, T. H., Hyduke, D. R., Liao, J. C., Rassaf, T., Bryan, N., Feelisch, M. and Lancaster, J. R., Jr (2002). Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiologicalal conditions. Proc. Natl. Acad. Sci. USA 99, 10341-10346.
62. Kapinya, K. J., Prass, K. and Dirnagl, U. (2002). Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism? NeuroReport 13, 1431-1435.
63. Kavanagh, R. J. and Kam, P. C. (2001). Lazaroids: efficacy and mechanism of action of the 21-aminosteroids in neuroprotection. Br. J. Anaesth. 86, 110-119.
64. Kim, G. W., Kondo, T., Noshita, N. and Chan, P. H. (2002). Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke 33, 809-815.
65. Kobayashi, T., Kuroda, S., Tada, M., Houkin, K., Iwasaki, Y. and Abe, H. (2003). Calcium-induced mitochondrial swelling and cytochrome c release in the brain: its biochemical characteristics and implication in ischemic neuronal injury. Brain Res. 960, 62-70.
66. Kondoh, S., Nagasawa, S., Kawanishi, M., Yamaguchi, K., Kajimoto, S. and Ohta, T. (1999). Effects of ebselen on cerebral ischemia and reperfusion evaluated by microdialysis. Neurol. Res. 21, 682-686.
67. Kristian, T. and Siesjo, B. K. (1996). Calcium-related damage in ischemia. Life Sci. 59, 357-367.
68. Kruman, I., Bruce-Keller, A. J., Bredesen, D., Waeg, G. and Mattson, M. P. (1997). Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17, 5089-5100.
69. Kumar, K., White, B. C., Krause, G. S., Indrieri, R. J., Evans, A. T., Hoehner, T. J., Garritano, A. M. and Koestner, A. (1988). A quantitative morphological assessment of the effect of lidoflazine and deferoxamine therapy on global brain ischaemia. Neurol. Res. 10, 136-140.
70. Kuroda, S., Tsuchidate, R., Smith, M. L., Maples, K. R. and Siesjo, B. K. (1999). Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 19, 778-787.
71. Kwon, T. H., Chao, D. L., Malloy, K., Sun, D., Alessandri, B. and Bullock, M. R. (2003). Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat. J. Neurotrauma 20, 337-345.
72. Lees, K. R., Barer, D., Ford, G. A., Hacke, W., Kostulas, V., Sharma, A. K. and Odergren, T. (2003). Tolerability of NXY-059 at higher target concentrations in patients with acute stroke. Stroke 34, 482-487.
73. Li, P. A., Kristian, T., He, Q. P. and Siesjo, B. K. (2000). Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp. Neurol. 165, 153-163.
74. Liachenko, S., Tang, P. and Xu, Y. (2003). Deferoxamine improves early postresuscitation reperfusion after prolonged cardiac arrest in rats. J. Cereb. Blood Flow Metab. 23, 574-581.
75. Lindsay, S., Liu, T. H., Xu, J. A., Marshall, P. A., Thompson, J. K., Parks, D. A., Freeman, B. A., Hsu, C. Y. and Beckman, J. S. (1991). Role of xanthine dehydrogenase and oxidase in focal cerebral ischemic injury to rat. Am. J. Physiol. 261, H2051-H2057.
76. Liochev, S. I. and Fridovich, I. (2002). The Haber-Weiss cycle - 70 years later: an alternative view. Redox Report 7, 55-57.
77. Liu, T. H., Beckman, J. S., Freeman, B. A., Hogan, E. L. and Hsu, C. Y. (1989). Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am. J. Physiol. 256, H589-H593.
78. Lo, E. H., Hara, H., Rogowska, J., Trocha, M., Pierce, A. R., Huang, P. L., Fishman, M. C., Wolf, G. L. and Moskowitz, M. A. (1996). Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. Stroke 27, 1381-1385.
79. Mackensen, G. B., Patel, M., Sheng, H., Calvi, C., Batinic-Haberle, I., Day, B. J., Liang, L. P., Fridovich, I., Crapo, J. D., Pearlstein, R. D. et al. (2001). Neuroprotection from delayed post-ischemic administration of a metalloporphyrin catalytic antioxidant. J. Neurosci. 21, 4582-4592.
80. Mandir, A. S., Poitras, M. F., Berliner, A. R., Herring, W. J., Guastella, D. B., Feldman, A., Poirier, G. G., Wang, Z. Q., Dawson, T. M. and Dawson, V. L. (2000). NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. J. Neurosci. 20, 8005-8011.
81. Marion, J. and Wolfe, L. S. (1979). Origin of the arachidonic acid released post-mortem in rat forebrain. Biochim. Biophys. Acta 574, 25-32.
82. Marklund, S. L. (1984). Extracellular superoxide dismutase in human tissues and human cell lines. J. Clin. Invest. 74, 1398-1403.
83. Marklund, S. L., Westman, N. G., Lundgren, E. and Roos, G. (1982). Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res. 42, 1955-1961.
84. (+)-ATPase activity during hypoxia in newborn piglets. Brain Res. 650, 9-15.
85. Marshall, J. J. and Kontos, H. A. (1990). Endothelium-derived relaxing factors. A perspective from in vivo data. Hypertension 16, 371-386.
86. Marshall, J. W. B., Duffin, K. J., Green, R. and Ridley, R. M. (2003). NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 32, 190-198.
87. Martz, D., Rayos, G., Schielke, G. P. and Betz, A. L. (1989). Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats. Stroke 20, 488-494.
88. Mattson, M. P., Culmsee, C. and Yu, Z. F. (2000). Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res. 301, 173-187.
89. Mikkelsen, R. B. and Wardman, P. (2003). Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 22, 5734-5754.
90. Morimoto, K., Tagawa, K., Hayakawa, T., Watanabe, F. and Mogami, H. (1982). Cellular level of purine compounds in ischemic gerbil brain by high performance liquid chromatography. J. Neurochem. 38, 833-835.
91. Morita-Fujimura, Y., Fujimura, M., Yoshimoto, T. and Chan, P. H. (2001). Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke. Stroke 32, 2356-2361.
92. Muller, A., Cadenas, E., Graf, P. and Sies, H. (1984). A novel biologically active seleno-organic compound-I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). Biochem. Pharmacol. 15, 3235-3239.
93. Murakami, K., Kondo, T., Kawasr, M., Li, Y., Sato, S., Chen, S. F. and Chan, P. H. (1998). Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J. Neurosci. 18, 205-213.
94. Myhre, O., Andersen, J. A., Aarnes, H. and Fonnum, F. (2003). Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem. Pharmacol. 65, 1575-1582.
95. Namba, K., Takeda, Y., Sunami, K. and Hirakawa, M. (2001). Temporal profiles of the levels of endogenous antioxidants after four-vessel occlusion in rats. J. Neurosurg. Anesthesiol. 13, 131-137.
96. Narasimhan, P., Fujimura, M., Noshita, N. and Chan, P. H. (2003). Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. Brain Res. Mol. Brain Res. 113, 28-36.
97. Nayini, N. R., White, B. C., Aust, S. D., Huang, R. R., Indrieri, R. J., Evans, A. T., Bialek, H., Jacobs, W. A. and Komara, J. (1985). Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest. Free Rad. Biol. Med. 1, 111-116.
98. Nelson, C. W., Wei, E. P., Povlishock, J. T., Kontos, H. A. and Moskowitz, M. A. (1992). Oxygen radicals in cerebral ischemia. Am. J. Physiol. 263, H1356-H1362.
99. Nicolescu, A. C., Zavorin, S. I., Turro, N. J., Reynolds, J. N. and Thatcher, G. R. (2002). Inhibition of lipid peroxidation in synaptosomes and liposomes by nitrates and nitrites. Chem. Res. Toxicol. 15, 985-998.
100. Nihei, H., Kanemitsu, H., Tamura, A., Oka, H. and Sano, K. (1989). Cerebral uric acid, xanthine, and hypoxanthine after ischemia: the effect of allopurinol. Neurosurgery 25, 613-617.
101. Niziolek, M., Korytowski, W. and Girotti, A. W. (2003). Nitric oxide inhibition of free radical-mediated lipid peroxidation in photodynamically treated membranes and cells. Free Rad. Biol. Med. 34, 997-1005.
102. Noshita, N., Sugawara, T., Hayashi, T., Lewen, A., Omar, G. and Chan, P. H. (2002). Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J. Neurosci. 22, 7923-7930.
103. O'Neill, M. J., Murray, T. K., McCarty, D. R., Hicks, C. A., Dell, C. P., Patrick, K. E., Ward, M. A., Osborne, D. J., Wiernicki, T. R., Roman, C. R. et al. (2000). ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res. 871, 234-244.
104. Okado-Matsumoto, A. and Fridovich, I. (2001). Subcellular distribution of superoxide dismutases (SOD) in rat liver. J. Biol. Chem. 276, 38388-38393.
105. 2 toxicity. Proc. Natl. Acad. Sci. USA 89, 9715-9719.
106. Palmer, C., Roberts, R. L. and Bero, C. (1994). Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25, 1039-1045.
107. Palmer, C., Towfighi, J., Roberts, R. L. and Heitjan, D. F. (1993). Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats. Pediatr. Res. 33, 405-411.
108. Palmer, C., Vannucci, R. C. and Towfighi, J. (1990). Reduction of perinatal hypoxic-ischemic brain damage with allopurinol. Pediatr. Res. 27, 332-336.
109. Park, E. M., Choi, J. H., Park, J. S., Han, M. Y. and Park, Y. M. (2000). Measurement of glutathione oxidation and 8-hydroxy-2′-deoxyguanosine accumulation in the gerbil hippocampus following global ischemia. Brain. Res. Brain Res. Protoc. 6, 25-32.
110. Parks, D. A. and Granger, D. N. (1986). Xanthine oxidase: biochemistry, distribution and physiology. Acta Physiol. Scand. Suppl. 548, 87-99.
111. Parmentier, S., Bohme, G. A., Lerouet, D., Damour, D., Stutzmann, J. M., Margaill, I. and Plotkine, M. (1999). Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br. J. Pharmacol. 127, 546-552.
112. Patt, A., Harken, A. H., Burton, L. K., Rodell, T. C., Piermattei, D., Schorr, W. J., Parker, N. B., Berger, E. M., Horesh, I. R., Terada, L. S. et al. (1988). Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. J. Clin. Invest. 81, 1556-1562.
113. Peeters-Scholte, C., Braun, K., Koster, J., Kops, N., Blomgren, K., Buonocore, G., Van Buul-Offers, S., Hagberg, H., Nicolay, K., Van Bel, F. et al. (2003). Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia. Pediatr. Res. 54, 516-522.
114. Perez Velazquez, J. L., Kokarovtseva, L., Weisspapir, M. and Frantseva, M. V. (2003). Anti-porin antibodies prevent excitotoxic and ischemic damage to brain tissue. J. Neurotrauma 20, 633-647.
115. Plaschke, K., Kopitz, J., Weigand, M. A., Martin, E. and Bardenheuer, H. J. (2000). The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia. Neurosci. Lett. 284, 109-112.
116. Przedborski, S., Jackson-Lewis, V., Kostic, V., Carlson, E., Epstein, C. J. and Cadet, J. L. (1992). Superoxide dismutase, catalase, and glutathione peroxidase activities in copper/zinc-superoxide dismutase transgenic mice. J. Neurochem. 58, 1760-1707.
117. Rao, A. M., Hatcher, J. F., Kindy, M. S. and Dempsey, R. J. (1999). Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. Neurochem. Res. 24, 1225-1232.
118. Riley, D. P. (2000). Rational design of synthetic enzymes and their potential utility as human pharmaceuticals. Adv. Supramol. Chem. 6, 217-244.
119. Rubbo, H., Radi, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., Kirk, M. and Freeman, B. A. (1994). Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J. Biol. Chem. 269, 26066-26075.
120. Saito, A., Hayashi, T., Okuno, S., Ferrand-Drake, M. and Chan, P. H. (2003). Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. J. Neurosci. 23, 1710-1718.
121. Saito, I., Asano, T., Sano, K., Takakura, K., Abe, H., Yoshimoto, T., Kikuchi, H., Ohta, T. and Ishibashi, S. (1998). Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 42, 269-277; Discussion 277-278.
122. Salvemini, D., Wang, Z. Q., Zweier, J. L., Samouilov, A., Macarthur, H., Misko, T. P., Currie, M. G., Cuzzocrea, S., Sikorski, J. A. and Riley, D. P. (1999). A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science 286, 209-210.
123. Sandstrom, J., Carlsson, L., Marklund, S. L. and Edlund, T. (1992). The heparin-binding domain of extracellular superoxide dismutase C and formation of variants with reduced heparin affinity. J. Biol. Chem. 267, 18205-18209.
124. Sarco, D. P., Becker, J., Palmer, C., Sheldon, R. A. and Ferriero, D. M. (2000). The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain. Neurosci. Lett. 282, 113-116.
125. Schewe, T. (1995). Molecular actions of ebselen - an antinflammatory antioxidant. Gen. Pharmacol. 26, 1153-1169.
126. Schonhoff, C. M., Gaston, B. and Mannick, J. B. (2003). Nitrosylation of cytochrome c during apoptosis. J. Biol. Chem. 278, 18265-18270.
127. Sharpe, M. A., Ollosson, R., Stewart, V. C. and Clark, J. B. (2002). Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics. Biochem. J. 366, 97-107.
128. Sheng, H., Bart, R. D., Oury, T. D., Pearlstein, R. D., Crapo, J. D. and Warner, D. S. (1999a). Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neuroscience 88, 185-191.
129. Sheng, H., Batinic-Haberle, I. and Warner, D. S. (2002a). Catalytic antioxidants as novel pharmacological approaches to treatment of ischemic brain injury. Drug News Perspect. 15, 654-665.
130. Sheng, H., Brody, T., Pearlstein, R. D., Crapo, J. and Warner, D. S. (1999b). Extracellular superoxide dismutase deficient mice have decreased resistance to focal cerebral ischemia. Neurosci. Lett. 267, 13-17.
131. Sheng, H., Enghild, J., Bowler, R., Patel, M., Batinic-Haberle, I., Calvi, C. L., Day, B. J., Pearlstein, R. D., Crapo, J. and Warner, D. S. (2002b). Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Free Rad. Biol. Med. 33, 947-961.
132. Sheng, H., Kudo, M., Mackensen, G. B., Pearlstein, R. D., Crapo, J. D. and Warner, D. S. (2000). Mice overexpressing extracellular superoxide dismutase have increased tolerance to global cerebral ischemia. Exp. Neurol. 163, 392-398.
133. Sies, H. (1991). Oxidative Stress II: Oxidants and Antioxidants. London: Academic Press.
134. Siesjo, B. K. and Wieloch, T. (1983). Fatty acid metabolism and the mechanisms of ischemic brain damage. In Cerebrovascular Diseases (ed. M. Reivich and H. I. Hurtig), pp. 251-268. New York: Raven Press.
135. Spasojevic, I., Batinic-Haberle, I. and Fridovich, I. (2000). Nitrosylation of manganese(III) tetrakis(N-ethylpyridmium-2-yl)porphyrin: A simple and sensitive spectrophotometric assay for nitric oxide. Nitric Oxide: Biol. Chem. 4, 526-533.
136. Sugawara, T., Lewen, A., Gasche, Y., Yu, F. and Chan, P. H. (2002a). Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release. FASEB J. 16, 1997-1999.
137. Sugawara, T., Noshita, N., Lewen, A., Gasche, Y., Ferrand-Drake, M., Fujimura, M., Morita-Fujimura, Y. and Chan, P. H. (2002b). Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J. Neurosci. 22, 209-217.
138. Sugawara, T., Yu, F., Ma, L., Hsia, C. J. and Chan, P. H. (2001). Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats. NeuroReport 12, 3609-3612.
139. Suzuki, M., Tabuchi, M., Ikeda, M. and Tomita, T. (2002). Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats. Brain Res. 951, 113-120.
140. 2+ and oxidant stress. Eur. J. Biochem. 238, 166-172.
141. Tarpey, M. and Fridovich, I. (2001). Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. Circ. Res. 89, 224-236.
142. The RANTTAS Investigators (1996). A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). Stroke 27, 1453-1458.
143. Tibell, L., Hjalmarsson, K., Edlund, T., Skogman, G., Engstom, A. and Marklund, S. L. (1987). Expression of human extracellular superoxide dismutase in Chinese hamster ovary cells and characterization of the product. Proc. Natl. Acad. Sci. USA 84, 6634-6638.
144. van Bel, F., Shadid, M., Moison, R. M., Dorrepaal, C. A., Fontijn, J., Monteiro, L., Van De Bor, M. and Berger, H. M. (1998). Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics 101, 185-193.
145. Vanella, A., Di Giacomo, C., Sorrenti, V., Russo, A., Castorina, C., Campisi, A., Renis, M. and Perez-Polo, J. R. (1993). Free radical scavenger depletion in post-ischemic reperfusion brain damage. Neurochem. Res. 18, 1337-1340.
146. Waldmeier, P. C., Zimmermann, K., Qian, T., Tintelnot-Blomley, M. and Lemasters, J. J. (2003). Cyclophilin D as a drug target. Curr. Med. Chem. 10, 1485-1506.
147. Watson, B. D. (1998). Usual and unusual methods for detection of lipid peroxides as indicators of tissue injury in cerebral ischemia: what is appropriate and useful? Cell. Mol. Neurobiol. 18, 581-598.
148. Watson, B. D., Busto, R., Goldberg, W. J., Santiso, M., Yoshida, S. and Ginsberg, M. D. (1984). Lipid peroxidation in vivo induced by reversible global ischemia in rat brain. J. Neurochem. 42, 268-274.
149. Wei, G., Dawson, V. L. and Zweier, J. L. (1999). Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia. Biochim. Biophys. Acta 1455, 23-34.
150. Weisbrot-Lefkowitz, M., Reuhl, K., Perry, B., Chan, P. H., Inouye, M. and Mirochnitchenko, O. (1998). Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage. Brain Res. Mol. Brain Res. 53, 333-338.
151. Williams, G. D., Palmer, C., Heitjan, D. F. and Smith, M. B. (1992). Allopurinol preserves cerebral energy metabolism during perinatal hypoxia-ischemia: a 31P NMR study in unanesthetized immature rats. Neurosci. Lett. 144, 103-106.
152. Wojtczak, L. (1976). Effect of long-chain fatty acids and acyl-CoA on mitochondrial permeability, transport, and energy-coupling processes. J. Bioenerg. Biomembr. 8, 293-311.
153. Yamaguchi, T., Sano, K., Takakura, K., Saito, I., Shinohara, Y., Asano, T. and Yasuhara, H. (1998). Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke 29, 12-17.
154. Yang, G., Chan, P. H., Chen, J., Carlson, E., Chen, S., Weinstein, P., Epstein, C. J. and Kamii, H. (1994). Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25, 165-170.
155. Yang, J., Klaidman, L. K., Chang, M. L., Kem, S., Sugawara, T., Chan, P. and Adams, J. D. (2002). Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model. Pharmacol. Biochem. Behav. 73, 901-910.
156. Yano, T., Ushijima, K. and Terasaki, H. (1998). Failure of glutathione peroxidase to reduce transient ischemic injury in the rat hippocampal CA1 subfield. Resuscitation 39, 91-98.
157. Yoshimoto, T., Kristian, T., Hu, B., Ouyang, H.-B. and Siesjo, B. K. (2002). NYX-059 maintains Akt activation and inhibits release of cytochrome c after focal cerebral ischemia. Brain Res. 947, 191-198.
158. Yue, T. L., Gu, J. L., Lysko, P. G., Cheng, H. Y., Barone, F. C. and Feuerstein, G. (1992). Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res. 574, 193-197.
159. Zhang, J. and Piantadosi, C. A. (1994). Prolonged production of hydroxyl radical in rat hippocampus after brain ischemia-reperfusion is decreased by 21-aminosteroids. Neurosci. Lett. 177, 127-130.
160. Zhao, H., Kalivendi, S., Zhang, H., Joseph, J., Nithipatikom, K., Vasquez-Vivar, J. and Kalyanaraman, B. (2003). Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Rad. Biol. Med. 34, 1359-1368.
161. Zhao, Q., Pahlmark, K., Smith, M. L. and Siesjö, B. K. (1994). Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152, 349-350.
162. Zhu, D. Y., Liu, S. H., Sun, H. S. and Lu, Y. M. (2003). Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J. Neurosci. 23, 223-229.