Interstitial pO2 in Ischemic Penumbra and Core are Differentially Affected Following Transient Focal Cerebral Ischemia in Rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 3, 2004, Pages 343-349

  Liu, Shimin ^a   Shi, Honglian ^a   Liu, Wenlan ^a   Furuichi, Takamitsu ^a,b   Timmins, Graham S ^a   Liu, Ke Jian ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Blood flow; Electron paramagnetic resonance; Focal cerebral ischemia; Hyperoxia; Interstitial oxygen tension; Penumbra

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; MALE; NERVE CELL NECROSIS; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TENSION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REPERFUSION; STROKE; TISSUE OXYGENATION; ANIMAL; BRAIN; BRAIN CIRCULATION; CEREBRAL ARTERY DISEASE; METABOLISM; MICROCIRCULATION; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSIENT ISCHEMIC ATTACK;

OXYGEN;

ANIMALS; BRAIN; CEREBROVASCULAR CIRCULATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MICROCIRCULATION; OXYGEN; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; REPERFUSION;

EID: 1542376859     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000110047.43905.01     Document Type: Article

References (39)

1. Astrup J, Siesjo BK, Symon L (1981) Thresholds in cerebral ischemia-the ischemic penumbra. Stroke 12:723-725
2. Belayev L, Zhao W, Busto R, Ginsberg MD (1997) Transient middle cerebral artery occlusion by intraluminal suture: I. Three-dimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationships during ischemia and early recirculation. J Cereb Blood Flow Metab 17:1266-1280
3. Brewer GJ (1997) Isolation and culture of adult rat hippocampal neurons. J Neurosci Methods 71(2):143-155
4. Charbel FT, Hoffman WE, Misra M, Hannigan K, Ausman JI (1997) Cerebral interstitial tissue oxygen tension, pH, HCO3, CO2. Surg Neurol 48:414-417
5. Doppenberg EM, Zauner A, Watson JC, Bullock R (1998) Determination of the ischemic threshold for brain oxygen tension. Acta Neurochir Suppl (Wien) 71:166-169
6. Dunn AK, Bolay H, Moskowitz MA, Boas DA (2001) Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab 21:195-201
7. Dunn JF, Grinberg O, Roche M, Nwaigwe CI, Hou HG, Swartz HM (2000). Noninvasive assessment of cerebral oxygenation during acclimation to hypobaric hypoxia. J Cereb. Blood Flow Metab. 20:1632-1635
8. Dunn JF, Swartz HM (2003) In vivo electron paramagnetic resonance oximetry with particulate materials. Methods 30:159-166
9. Fisher M (1997) Characterizing the target of acute stroke therapy. Stroke 28:866-872
10. Frykholm P, Andersson JL, Valtysson J, Silander HC, Hillered L, Persson L, Olsson Y, Yu WR, Westerberg G, Watanabe Y, Langstrom B, Enblad P (2000) A metabolic threshold of irreversible ischemia demonstrated by PET in a middle cerebral artery occlusion-reperfusion primate model. Acta Neurol Scand 102:18-26
11. Gupta AK, Hutchinson PJ, Fryer T, Al-Rawi PG, Parry DA, Minhas PS, Kett-White R, Kirkpatrick PJ, Mathews JC, Downey S, Aigbirhio F, Clark J, Pickard JD, Menon DK (2002) Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method. J Neurosurg 96:263-268
12. Harris RJ, Richards PG, Symon L, Habib AH, Rosenstein J (1987) pH, K+, and PO2 of the extracellular space during ischemia of primate cerebral cortex. J Cereb Blood Flow Metab 7:599-604
13. Heiss WD, Graf R, Wienhard K, Lottgen J, Saito R, Fujita T, Rosner G, Wagner R (1994) Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab 14:892-902
14. Hoffman WE, Charbel FT, Edelman G, Ausman JI (1997) Brain tissue oxygenation in patients with cerebral occlusive disease and arteriovenous malformations. Br J Anaesth 78:169-171
15. Holzschuh M, Woertgen C, Metz C, Brawanski A (1997) Dynamic changes of cerebral oxygenation measured by brain tissue oxygen pressure and near infrared spectroscopy. Neurol Res 19:246-248
16. Hou H, Grinberg OY, Taie S, Leichtweis S, Miyake M, Grinberg S, Xie H, Csete M, Swartz HM (2003) Electron paramagnetic resonance assessment of brain tissue oxygen tension in anesthetized rats. Anesthesia & Analgesia. 96:1467-1472
17. James PE, Grinberg OY, Michaels G, Swartz HM (1995) Intraphagosomal oxygen in stimulated macrophages. J Cell Physiol 163:241-247
18. Jodicke A, Hubner F, Boker DK (2003) Monitoring of brain tissue oxygenation during aneurysm surgery: prediction of procedure-related ischemic events. J Neurosurg 98:515-523
19. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema, I: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8:1-8
20. Kuge Y, Yokota C, Tagaya M, Hasegawa Y, Nishimura A, Kito G, Tamaki N, Hashimoto N, Yamaguchi T, Minematsu K (2001) Serial changes in cerebral blood flow and flow-metabolism uncoupling in primates with acute thromboembolic stroke. J Cereb Blood Flow Metab 21:202-210
21. Kuroda S, Siesjo BK (1997) Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci 4:199-212
22. Liu KJ, Gast P, Moussavi M, Norby SW, Vahidi N, Walczak T, Wu M, Swartz HM (1993) Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems. Proc Natl Acad Sci U S A 90:5438-5442
23. Liu KJ, Bacic G, Hoopes PJ, Jiang J, Du H, Ou LC, Dunn JF, Swartz HM (1995). Assessment of cerebral pO2 by EPR oximetry in rodents: effects of anesthesia, ischemia, and breathing gas. Brain Res. 685:91-98
24. Liu S, Connor J, Peterson S, Shuttleworth CW, Liu KJ (2002) Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion. J Cereb Blood Flow Metab 22:1222-1230
25. Liu S, Liu M, Peterson S, Miyake M, Vallyathan V, Liu KJ (2003) Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke. J Neurosci Res 71:882-888
26. Martinez-Tica JF, Berbarie R, Davenport P, Zornow MH (1999) Monitoring brain PO2, PCO2, and pH during graded levels of hypoxemia in rabbits. J Neurosurg Anesthesiol 11:260-263
27. Nakai A, Kuroda S, Kristian T, Siesjo BK (1997) The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat. Neurobiol Dis 4:288-300
28. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Orlando: Academic Press. P1-236
29. 31P-NMR and EPR oximetry study. Am. J. Physiol. - Regulatory Integrative Comparative Physiology. 279:R9-R16
30. Rosenberg GA (1999) Ischemic brain edema. Prog Cardiovasc Dis 42:209-216
31. Rusyniak DE, Kirk MA, May JD, Kao LW, Brizendine EJ, Welch JL, Cordell WH, Alonso RJ (2003) Hyperbaric oxygen therapy in acute ischemic stroke: results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial Pilot Study. Stroke 34:571-574
32. Singhal AB, Wang X, Sumii T, Mori T, Lo EH (2002a) Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 22:861-868
33. Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH (2002b) Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 58:945-952
34. Sugo N, Hum PD, Morahan MB, Hattori K, Traystman RJ, DeVries AC (2002) Social stress exacerbates focal cerebral ischemia in mice. Stroke 33:1660-1664
35. Takagi K, Ginsberg MD, Globus MY, Martinez E, Busto R (1994) Effect of hyperthermia on glutamate release in ischemic penumbra after middle cerebral artery occlusion in rats. Am J Physiol. 267:H1770-H1776
36. Tammela OK, Lajevardi N, Huang CC, Wilson DF, Delivoria-Papadopoulos M, Pastuszko A (1996) The effects of induced apneic episodes on cerebral cortical oxygenation in newborn piglets. Brain Res 741:160-165
37. Velan SS, Spencer RG, Zweier JL, Kuppusamy P (2000) Electron paramagnetic resonance oxygen mapping (EPROM): direct visualization of oxygen concentration in tissue Magnet. Reson. Med. 43:804-809
38. Westermaier T, Hungerhuber E, Zausinger S, Baethmann A, Schmid-Elsaesser R (2003) Neuroprotective efficacy of intra-arterial and intravenous magnesium sulfate in a rat model of transient focal cerebral ischemia. Acta Neurochir (Wien) 145:393-399
39. Zhao W, Belayev L, Ginsberg MD (1997) Transient middle cerebral artery occlusion by intraluminal suture: II. Neurological deficits, and pixel-based correlation of histopathology with local blood flow and glucose utilization. J Cereb Blood Flow Metab 17:1281-1290